SIRPB2 Gene
protein-coding GIFtS: 38
GCID: GC20M001451
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signal-regulatory protein beta 2(Previous names: protein tyrosine phosphatase, non-receptor type 1-like,...)
(Previous symbols: PTPN1L, PTPNS1L3)
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Aliases
for SIRPB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal-Regulatory Protein Beta 21 2 | | Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein2 3 | | PTPN1L1 2 3 | | SIRP-Beta-21 | | PTPNS1L31 2 3 | | Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like1 | | DJ776F14.21 | | Signal-Regulatory Protein Beta-22 | | Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 31 2 | | SIRPG5 | | Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 32 3 | | |
Export aliases for SIRPB2 gene to outside databasesPrevious GC identifers: GC20M001597 GC20M001604 GC20M001557 GC20M001400 |
Summaries
for SIRPB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SIRPB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SIRPB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIRPB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13SIRPB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M001451: view genomic region
(about GC identifiers)
Start:
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1,451,386 bp from pter |
End:
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1,472,233 bp from pter |
Size:
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20,848 bases |
Orientation:
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minus strand |
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Proteins
for SIRPB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIRB2_HUMAN, Q5JXA9 (See
protein sequence)Recommended Name: Signal-regulatory protein beta-2 precursor Size: 342 amino acids; 36968 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B4DLM9 E9PCW6 Q6TCH9Alternative splicing: 3 isoforms: Q5JXA9-1 Q5JXA9-2 Q5JXA9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIRPB2: NX_Q5JXA9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JXA9
SIRPB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001116434.1 NP_001128308.1
ENSEMBL proteins: ENSP00000432656 ENSP00000435045 ENSP00000352849 ENSP00000371043 ENSP00000402438 ENSP00000445632
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SIRPB2 for ontologies About GeneDecksing
SIRPB2 Antibody Products:
Assay Products for SIRPB2: |
Protein
Domains /
Families
for SIRPB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIRPB2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JXA9ProtoNet protein and cluster: Q5JXA9 UniProtKB/Swiss-Prot: SIRB2_HUMAN, Q5JXA9Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains |
Function
for SIRPB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SIRPB2 (NM_001122962) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRPB2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIRPB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
SIRPB2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SIRPB2:
|
Pathways & Interactions
for SIRPB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRPB2
|
Drugs & Compounds
for SIRPB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIRPB2
Search CenterWatch for drugs/clinical trials and news about SIRPB2 / SIRB2
|
Transcripts
for SIRPB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIRPB2 gene (2 alternative transcripts): NM_001122962.1 NM_001134836.1 Unigene Cluster for SIRPB2: Signal-regulatory protein beta 2 Hs.721685 [show with all ESTs]Unigene Representative Sequence: NM_0011229626 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481731 ENST00000486775 ENST00000359801(uc002wfg.2) ENST00000381630
ENST00000444444(uc002wfh.3) ENST00000537284(uc010zpr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIRPB2 (NM_001122962) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRPB2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIRPB2 |
Additional cDNA sequence: AK095499.1 AK294440.1 AK297072.1 AY424277.1 6 DOTS entries: DT.99998252 DT.86842023 DT.100008356 DT.100768319 DT.120798528 DT.120798734 19 AceView cDNA sequences: BX417137 BM280366 BM280286 AW473927 AK095499 BG539998 BM280291 AY424277 AL844283 BQ635335 BM285394 AL844323 AL732097 AK097113 AL844285 BF836038 BF838298 AL732098 BI023360
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIRPB2
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Expression
for SIRPB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIRPB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SIRPB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRPB2
SOURCE GeneReport for Unigene cluster: Hs.721685
SABiosciences Custom PCR Arrays for SIRPB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRPB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIRPB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB2 |
Orthologs
for SIRPB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIRPB2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for SIRPB2 (if available)
TreeFam Gene Tree for SIRPB2 (if available) |
Paralogs
for SIRPB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIRPB2 gene
- SIRPD2 SIRPB12 ENSG000002608612 SIRPA2 SIRPG2
4 SIMAP similar genes for SIRPB2 using alignment to 4 protein entries: SIRB2_HUMAN (see all proteins):SIRPB1 PTPNS1 SIRPD SIRPG
SIRPB2 for paralogs About GeneDecksing
|
Genomic Variants
for SIRPB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIRPB2 (1451386 - 1472233 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIRPB2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRPB2 |
|
Disorders
/ Diseases
for SIRPB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIRPB2 for disorders About GeneDecksing
OMIM gene information: 605466
OMIM disorders: --
2  diseases for SIRPB2: About MalaCardsataxia telangiectasia ataxia
Export disorders for SIRPB2 gene to outside databases
|
Publications
for SIRPB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIRPB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIRPB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A nomenclature for signal regulatory protein family m embers. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. (PubMed id 17178844)1 Nyati M.K....Lawrence T.S. (2006)
- Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. (PubMed id 12213963)1 Chen J....Wang S.M. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SIRPB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SIRPB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIRPB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIRPB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIRPB2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SIRPB2 gene:
Search GeneIP for patents involving SIRPB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIRPB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIRPB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRPB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRPB2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIRPB2 | | OriGene 3'-UTR Clone for SIRPB2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIRPB2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIRPB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRPB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRPB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPB2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SIRPB2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SIRPB2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIRPB2 |
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