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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIRPB2 Gene

protein-coding   GIFtS: 41
GCID: GC20M001451

Signal-Regulatory Protein Beta 2

(Previous names: protein tyrosine phosphatase, non-receptor type 1-like,...)
(Previous symbols: PTPN1L, PTPNS1L3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal-Regulatory Protein Beta 21 2     SIRP-beta-22 3
PTPN1L1 2 3     Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like1
PTPNS1L31 2 3     dJ776F14.22
Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 31 2     Signal-Regulatory Protein Beta-22
Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 32 3     SIRPG5
Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein2 3     

External Ids:    HGNC: 162471   Entrez Gene: 2847592   Ensembl: ENSG000001962097   OMIM: 6054665   UniProtKB: Q5JXA93   

Export aliases for SIRPB2 gene to outside databases

Previous GC identifers: GC20M001597 GC20M001604 GC20M001557 GC20M001400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIRPB2 Gene: 
SIRPB2 (signal-regulatory protein beta 2) is a protein-coding gene. Diseases associated with SIRPB2 include ataxia telangiectasia, and ataxia. An important paralog of this gene is SIRPD.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SIRPB2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRPB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIRPB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SIRPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRPB2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001451:  view genomic region     (about GC identifiers)

Start:
1,451,386 bp from pter      End:
1,472,233 bp from pter
Size:
20,848 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIRB2_HUMAN, Q5JXA9 (See protein sequence)
Recommended Name: Signal-regulatory protein beta-2 precursor  
Size: 342 amino acids; 36968 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B4DLM9 E9PCW6 Q6TCH9
Alternative splicing: 3 isoforms:  Q5JXA9-1   Q5JXA9-2   Q5JXA9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRPB2: NX_Q5JXA9

Explore proteomics data for SIRPB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JXA9

  • SIRPB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIRPB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116434.1  NP_001128308.1  

    ENSEMBL proteins: 
     ENSP00000432656   ENSP00000435045   ENSP00000352849   ENSP00000371043   ENSP00000402438  
     ENSP00000445632  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SIRPB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SIRP: Signal-regulatory proteins
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q5JXA9

    ProtoNet protein and cluster: Q5JXA9

    UniProtKB/Swiss-Prot: SIRB2_HUMAN, Q5JXA9
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    SIRPB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SIRPB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIRPB2:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIRPB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIRPB2

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    hsa-miR-28-3p hsa-miR-3934 hsa-miR-492 hsa-miR-149 hsa-miR-1301 hsa-miR-548u hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidSIRPB2 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of SIRPB2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRPB2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIRPB2 (SIRB2)

    Search CenterWatch for drugs/clinical trials and news about SIRPB2 / SIRB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIRPB2 gene (2 alternative transcripts): 
    NM_001122962.1  NM_001134836.1  

    Unigene Cluster for SIRPB2:

    Signal-regulatory protein beta 2
    Hs.721685  [show with all ESTs]
    Unigene Representative Sequence: NM_001122962
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481731 ENST00000486775 ENST00000359801(uc002wfg.2) ENST00000381630
    ENST00000444444(uc002wfh.3) ENST00000537284(uc010zpr.1)
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRPB2:
    hsa-miR-28-3p hsa-miR-3934 hsa-miR-492 hsa-miR-149 hsa-miR-1301 hsa-miR-548u hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidSIRPB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIRPB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRPB2
    Clone
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    OriGene ORF clones in mouse, rat for SIRPB2
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    GenScript: all cDNA clones in your preferred vector (see all 2): SIRPB2 (NM_001122962)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIRPB2
    Sirion Biotech Customized lentivirus for stable overexpression of SIRPB2 
                         Customized lentivirus expression plasmids for stable overexpression of SIRPB2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SIRPB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPB2

    Additional mRNA sequence: 

    AK095499.1 AK294440.1 AK297072.1 AY424277.1 

    6 DOTS entries:

    DT.99998252  DT.86842023  DT.100008356  DT.100768319  DT.120798528  DT.120798734 

    19 AceView cDNA sequences:

    AW473927 BM280286 BX417137 BM280366 BM280291 AK095499 AY424277 BG539998 
    BM285394 BQ635335 AL844283 AL844323 AL732097 AL844285 AK097113 BF836038 
    BF838298 BI023360 AL732098 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                                               -                     
    SP2:                    -                                                                     
    SP3:                    -           -     -                                                   
    SP4:                                      -                                                   


    ECgene alternative splicing isoforms for SIRPB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIRPB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SIRPB2 Expression
    About this image


    See SIRPB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIRPB2

    SOURCE GeneReport for Unigene cluster: Hs.721685
        SABiosciences Custom PCR Arrays for SIRPB2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIRPB2 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm51505 predicted gene 5150   --   3 (3.91 cM) 15948070 


    ENSEMBL Gene Tree for SIRPB2 (if available)
    TreeFam Gene Tree for SIRPB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIRPB2 gene
    SIRPD2  SIRPB12  SIRPG2  SIRPA2  ENSG000002608612  
    4 SIMAP similar genes for SIRPB2 using alignment to 4 protein entries:     SIRB2_HUMAN (see all proteins):
    SIRPB1    PTPNS1    SIRPD    SIRPG

    SIRPB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 SNPs in SIRPB2 are shown (see all 527)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404204371,2
    --1454821(+) CCCCAG/TCTCAA 2 -- ds50010--------
    rs1869948731,2
    --1454877(+) TTTTTA/CTTTTT 2 -- ds50010--------
    rs60792621,2
    H--1454969(+) taccTT/CCCCTA 2 -- ds50014Minor allele frequency- C:0.00NS EA 390
    rs1910728711,2
    --1455036(+) TTGTCC/GCTGGC 2 -- ds50010--------
    rs1442918501,2
    --1455154(+) TTTACA/GTGTAT 2 -- ds50010--------
    rs9658051,2
    C,A--1455168(+) GTGCAC/TGCAGT 2 -- ds500112Minor allele frequency- T:0.05NA WA CSA EA 374
    rs1829187311,2
    --1455178(+) TGCACA/CCAGCA 2 -- ds50010--------
    rs764351451,2
    C,F--1455205(+) TAAATG/ACAGAA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1875953571,2
    C--1455321(+) CAAGCA/GGTTCT 2 -- ut310--------
    rs1907564581,2
    --1455353(+) GCTGGA/GATTAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SIRPB2 (1451386 - 1472233 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SIRPB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3252CNV Insertion18451855
    nsv833893CNV Loss17160897
    nsv522008CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605466    OMIM disorders: --

    2 diseases for SIRPB2:    About MalaCards
    ataxia telangiectasia    ataxia


    SIRPB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIRPB2

    Export disorders for SIRPB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIRPB2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SIRPB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nomenclature for signal regulatory protein family m embers. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide and gene-centric analyses of circulating m yeloperoxidase levels in the charge and care consortia. (PubMed id 23620142)1 Reiner A.P....Allayee H. (2013)
    4. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. (PubMed id 17178844)1 Nyati M.K....Lawrence T.S. (2006)
    5. Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags. (PubMed id 12213963)1 Chen J....Wang S.M. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284759 HGNC: 16247 AceView: PTPNS1L3 Ensembl:ENSG00000196209 euGenes: HUgn284759
    ECgene: SIRPB2 H-InvDB: SIRPB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIRPB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIRPB2 gene:
    Search GeneIP for patents involving SIRPB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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