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Aliases for SIRPB2 Gene

Aliases for SIRPB2 Gene

  • Signal-Regulatory Protein Beta 2 2 3
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 3 2 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 3 3 4
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein 3 4
  • SIRP-Beta-2 3 4
  • PTPNS1L3 3 4
  • PTPN1L 3 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like 2
  • Signal-Regulatory Protein Beta-2 3
  • DJ776F14.2 3
  • SIRPG, 6

External Ids for SIRPB2 Gene

Previous Symbols for SIRPB2 Gene

  • PTPN1L
  • PTPNS1L3

Summaries for SIRPB2 Gene

GeneCards Summary for SIRPB2 Gene

SIRPB2 (Signal-Regulatory Protein Beta 2) is a Protein Coding gene. Among its related pathways are Hemostasis and Cell junction organization. An important paralog of this gene is SIRPB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPB2 Gene

Genomics for SIRPB2 Gene

Genomic Location for SIRPB2 Gene

1,470,741 bp from pter
1,491,587 bp from pter
20,847 bases
Minus strand

Genomic View for SIRPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPB2 Gene

No data available for Regulatory Elements for SIRPB2 Gene

Proteins for SIRPB2 Gene

  • Protein details for SIRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-regulatory protein beta-2
    Protein Accession:
    Secondary Accessions:
    • B4DLM9
    • E9PCW6
    • Q6TCH9

    Protein attributes for SIRPB2 Gene

    342 amino acids
    Molecular mass:
    36968 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIRPB2 Gene


neXtProt entry for SIRPB2 Gene

Proteomics data for SIRPB2 Gene at MOPED

Post-translational modifications for SIRPB2 Gene

  • Glycosylation at Asn116, Asn179, and Asn231

Other Protein References for SIRPB2 Gene

No data available for DME Specific Peptides for SIRPB2 Gene

Domains for SIRPB2 Gene

Gene Families for SIRPB2 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing
  • SIRP :Signal-regulatory proteins

Protein Domains for SIRPB2 Gene


  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.:
    • Q5JXA9
genes like me logo Genes that share domains with SIRPB2: view

Function for SIRPB2 Gene

Gene Ontology (GO) - Molecular Function for SIRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SIRPB2: view

Phenotypes for SIRPB2 Gene

GenomeRNAi human phenotypes for SIRPB2:
genes like me logo Genes that share phenotypes with SIRPB2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIRPB2 Gene

Localization for SIRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SIRPB2 Gene COMPARTMENTS Subcellular localization image for SIRPB2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SIRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPB2: view

Pathways for SIRPB2 Gene

genes like me logo Genes that share pathways with SIRPB2: view

Pathways by source for SIRPB2 Gene

Interacting Proteins for SIRPB2 Gene

Gene Ontology (GO) - Biological Process for SIRPB2 Gene


Transcripts for SIRPB2 Gene

Unigene Clusters for SIRPB2 Gene

Signal-regulatory protein beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for SIRPB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIRPB2 Gene

mRNA expression in normal human tissues for SIRPB2 Gene

mRNA differential expression in normal tissues according to GTEx for SIRPB2 Gene

This gene is overexpressed in Whole Blood (32.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SIRPB2 Gene

SOURCE GeneReport for Unigene cluster for SIRPB2 Gene Hs.721685

genes like me logo Genes that share expressions with SIRPB2: view

Orthologs for SIRPB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIRPB2 36
  • 99.22 (n)
  • 98.83 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SIRPB2 36
  • 81 (n)
  • 73.94 (a)
  • 59 (a)
(Canis familiaris)
Mammalia SIRPB2 36
  • 80.51 (n)
  • 70.77 (a)
  • 68 (a)
(Mus musculus)
Mammalia F830045P16Rik 37
  • 6 (a)
Gm5150 16
(Monodelphis domestica)
Mammalia -- 37
  • 19 (a)
-- 37
  • 44 (a)
-- 37
  • 38 (a)
-- 37
  • 15 (a)
(Gallus gallus)
Aves -- 37
  • 15 (a)
-- 37
  • 16 (a)
-- 37
  • 20 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 12 (a)
-- 37
  • 19 (a)
-- 37
  • 13 (a)
Species with no ortholog for SIRPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPB2 Gene

Gene Tree for SIRPB2 (if available)
Gene Tree for SIRPB2 (if available)

Paralogs for SIRPB2 Gene

Paralogs for SIRPB2 Gene

Selected SIMAP similar genes for SIRPB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SIRPB2: view

Variants for SIRPB2 Gene

Sequence variations from dbSNP and Humsavar for SIRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs715217 -- 1,491,762(+) TGCAG(C/T)GTAGG upstream-variant-2KB
rs715218 -- 1,491,778(+) CGGCA(A/G)TTCCC upstream-variant-2KB
rs958839 -- 1,491,257(+) GTTCT(A/G)TCCTA intron-variant
rs965805 -- 1,474,523(+) GTGCA(C/T)GCAGT downstream-variant-500B
rs984497 -- 1,475,165(+) CCCCA(C/T)ATCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIRPB2 Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
nsv833893 CNV Loss 17160897
nsv3252 CNV Insertion 18451855

Relevant External Links for SIRPB2 Gene

HapMap Linkage Disequilibrium report

Disorders for SIRPB2 Gene

Relevant External Links for SIRPB2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SIRPB2: view

No data available for UniProtKB/Swiss-Prot for SIRPB2 Gene

Publications for SIRPB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3
  3. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. (PMID: 17178844) Nyati M.K. … Lawrence T.S. (Cancer Res. 2006) 3
  4. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. (PMID: 23620142) Reiner A.P. … Allayee H. (Hum. Mol. Genet. 2013) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4

Products for SIRPB2 Gene

Sources for SIRPB2 Gene

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