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Aliases for SIRPB2 Gene

Aliases for SIRPB2 Gene

  • Signal Regulatory Protein Beta 2 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 3 2 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein 3 4
  • SIRP-Beta-2 3 4
  • PTPNS1L3 3 4
  • PTPN1L 3 4
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 3 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like 2
  • Signal-Regulatory Protein Beta 2 2
  • Signal-Regulatory Protein Beta-2 3
  • DJ776F14.2 3

External Ids for SIRPB2 Gene

Previous HGNC Symbols for SIRPB2 Gene

  • PTPN1L
  • PTPNS1L3

Previous GeneCards Identifiers for SIRPB2 Gene

  • GC20M001597
  • GC20M001604
  • GC20M001557
  • GC20M001400

Summaries for SIRPB2 Gene

GeneCards Summary for SIRPB2 Gene

SIRPB2 (Signal Regulatory Protein Beta 2) is a Protein Coding gene. An important paralog of this gene is SIRPB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPB2 Gene

Genomics for SIRPB2 Gene

Regulatory Elements for SIRPB2 Gene

Enhancers for SIRPB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F001488 1 FANTOM5 ENCODE 48.5 +0.8 757 4.0 HDGF ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 SIRPB2 NSFL1C SDCBP2 SIRPB1 ENSG00000242324 SIRPD FKBP1A MIR6869 SIRPA
GH20F001493 0.3 FANTOM5 26.3 -2.1 -2137 0.2 ZKSCAN1 SIRPB2 SDCBP2 SIRPA SIRPB1 PIR45069
GH20F001499 1.1 Ensembl ENCODE 23.3 -8.8 -8775 2.6 ZNF639 ZNF366 ATF3 ZBTB11 TEAD2 PRDM10 NSFL1C SIRPB2 SDCBP2 FKBP1A MIR6869 SNPH PIR45069
GH20F001505 0.6 ENCODE 23 -14.3 -14257 1.5 SIRPB2 SDCBP2 NSFL1C FKBP1A MIR6869 SNPH PIR45069 LOC105372499
GH20F001484 0.2 Ensembl 22.3 +6.6 6587 1.2 YY2 SP5 ZBTB11 SIN3A DMAP1 FEZF1 ZEB1 ZFP69B ZNF335 BCL11A SIRPB2 NSFL1C
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIRPB2 on UCSC Golden Path with GeneCards custom track

Promoters for SIRPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000396461 587 1201 ZNF146 ZMYM3 MAX CEBPB MYC NR2F2

Genomic Location for SIRPB2 Gene

Chromosome:
20
Start:
1,470,688 bp from pter
End:
1,491,587 bp from pter
Size:
20,900 bases
Orientation:
Minus strand

Genomic View for SIRPB2 Gene

Genes around SIRPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPB2 Gene

Proteins for SIRPB2 Gene

  • Protein details for SIRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JXA9-SIRB2_HUMAN
    Recommended name:
    Signal-regulatory protein beta-2
    Protein Accession:
    Q5JXA9
    Secondary Accessions:
    • B4DLM9
    • E9PCW6
    • Q6TCH9

    Protein attributes for SIRPB2 Gene

    Size:
    342 amino acids
    Molecular mass:
    36968 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIRPB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPB2 Gene

Post-translational modifications for SIRPB2 Gene

  • Glycosylation at Asn 116, Asn 179, and Asn 231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIRPB2 Gene

Domains & Families for SIRPB2 Gene

Protein Domains for SIRPB2 Gene

Suggested Antigen Peptide Sequences for SIRPB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JXA9

UniProtKB/Swiss-Prot:

SIRB2_HUMAN :
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with SIRPB2: view

Function for SIRPB2 Gene

Phenotypes for SIRPB2 Gene

genes like me logo Genes that share phenotypes with SIRPB2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIRPB2 Gene

Localization for SIRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPB2 Gene COMPARTMENTS Subcellular localization image for SIRPB2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SIRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPB2: view

Pathways & Interactions for SIRPB2 Gene

SuperPathways for SIRPB2 Gene

No Data Available

Interacting Proteins for SIRPB2 Gene

Gene Ontology (GO) - Biological Process for SIRPB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SIRPB2 Gene

Transcripts for SIRPB2 Gene

Unigene Clusters for SIRPB2 Gene

Signal-regulatory protein beta 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for SIRPB2 Gene

GeneLoc Exon Structure for
SIRPB2
ECgene alternative splicing isoforms for
SIRPB2

Expression for SIRPB2 Gene

mRNA expression in normal human tissues for SIRPB2 Gene

mRNA differential expression in normal tissues according to GTEx for SIRPB2 Gene

This gene is overexpressed in Whole Blood (x32.0).

Protein differential expression in normal tissues from HIPED for SIRPB2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIRPB2 Gene



Protein tissue co-expression partners for SIRPB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIRPB2 Gene:

SIRPB2

SOURCE GeneReport for Unigene cluster for SIRPB2 Gene:

Hs.721685
genes like me logo Genes that share expression patterns with SIRPB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SIRPB2 Gene

Orthologs for SIRPB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPB2 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia SIRPB2 34 35
  • 81 (n)
dog
(Canis familiaris)
Mammalia SIRPB2 34 35
  • 80.51 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 19 (a)
OneToMany
-- 35
  • 15 (a)
OneToMany
mouse
(Mus musculus)
Mammalia F830045P16Rik 35
  • 6 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 20 (a)
OneToMany
-- 35
  • 16 (a)
OneToMany
-- 35
  • 15 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 19 (a)
OneToMany
-- 35
  • 13 (a)
OneToMany
-- 35
  • 12 (a)
OneToMany
Species where no ortholog for SIRPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPB2 Gene

ENSEMBL:
Gene Tree for SIRPB2 (if available)
TreeFam:
Gene Tree for SIRPB2 (if available)

Paralogs for SIRPB2 Gene

Paralogs for SIRPB2 Gene

(2) SIMAP similar genes for SIRPB2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SIRPB2: view

Variants for SIRPB2 Gene

Sequence variations from dbSNP and Humsavar for SIRPB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10211750 -- 1,491,471(+) AGCTG(C/T)TTGGG upstream-variant-2KB, utr-variant-5-prime
rs111337395 -- 1,483,226(+) CTCAG(C/G)CTCCT intron-variant
rs111394704 -- 1,479,377(+) TGACT(A/T)GCTTT intron-variant
rs111417894 -- 1,484,415(+) AAACT(C/T)TTGAA intron-variant
rs111422434 -- 1,478,409(+) GCACC(A/G/T)CTGTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIRPB2 Gene

Variant ID Type Subtype PubMed ID
nsv3252 CNV insertion 18451855
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv833893 CNV loss 17160897
nsv952971 CNV duplication 24416366

Variation tolerance for SIRPB2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPB2 Gene

Disorders for SIRPB2 Gene

Relevant External Links for SIRPB2

Genetic Association Database (GAD)
SIRPB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPB2

No disorders were found for SIRPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPB2 Gene

Publications for SIRPB2 Gene

  1. The SIRP family of receptors and immune regulation. (PMID: 16691243) Barclay A.N. … Brown M.H. (Nat. Rev. Immunol. 2006) 2 3 64
  2. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. (PMID: 23620142) Reiner A.P. … Allayee H. (Hum. Mol. Genet. 2013) 3 64
  5. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. (PMID: 17178844) Nyati M.K. … Lawrence T.S. (Cancer Res. 2006) 3 64

Products for SIRPB2 Gene

Sources for SIRPB2 Gene

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