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Aliases for SIRPB1 Gene

Aliases for SIRPB1 Gene

  • Signal Regulatory Protein Beta 1 2 3 5
  • CD172 Antigen-Like Family Member B 3 4
  • SIRP-BETA-1 3 4
  • Signal-Regulatory Protein Beta 1 2
  • Signal-Regulatory Protein Beta-1 3
  • SIRP-Beta-1 Isoform 3 4
  • CD172b Antigen 4
  • CD172b 3

External Ids for SIRPB1 Gene

Previous GeneCards Identifiers for SIRPB1 Gene

  • GC20M001531
  • GC20M001538
  • GC20M001491
  • GC20M001544
  • GC20M001495

Summaries for SIRPB1 Gene

Entrez Gene Summary for SIRPB1 Gene

  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for SIRPB1 Gene

SIRPB1 (Signal Regulatory Protein Beta 1) is a Protein Coding gene. Diseases associated with SIRPB1 include Composite Lymphoma. Among its related pathways are Immune System and Osteoclast differentiation. An important paralog of this gene is SIRPA.

UniProtKB/Swiss-Prot for SIRPB1 Gene

  • Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

  • Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

Gene Wiki entry for SIRPB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPB1 Gene

Genomics for SIRPB1 Gene

Regulatory Elements for SIRPB1 Gene

Enhancers for SIRPB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F001566 1.1 FANTOM5 Ensembl ENCODE 64.6 +57.8 57767 4.9 CTCF ATF1 JUN BACH1 RFX5 ZNF316 NFE2 FOS CREM MAFK SIRPB1 ENSG00000271523 SIRPG SDCBP2 SIRPB2 SIRPA SIRPD
GH20F001619 0.5 ENCODE 61.1 +6.5 6493 0.9 HDGF ZNF263 WRNIP1 EED IKZF1 ETV6 MYC SPI1 SIRPB1 ENSG00000271523 ENSG00000260861
GH20F001535 1.2 Ensembl ENCODE 28.8 +89.4 89427 3.9 HDGF CTCF TBL1XR1 MAX RELA CBX5 EED ZNF143 ETV6 NFE2 SIRPB1 NSFL1C SIRPD ENSG00000242324 ENSG00000271523 RNU6-917P
GH20F001622 0.5 ENCODE 26.5 +3.9 3891 1.2 HDGF SRF MTA2 TRIM22 TBX21 RAD51 EED IKZF1 TARDBP NBN SIRPB1 ENSG00000260861
GH20F001912 0.2 ENCODE 18.7 -286.2 -286191 0.8 ZNF335 CTCF ZNF547 ZBTB20 TCF7L2 SIRPB1 ENSG00000276649 LOC727993
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIRPB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIRPB1 Gene

Chromosome:
20
Start:
1,563,521 bp from pter
End:
1,626,497 bp from pter
Size:
62,977 bases
Orientation:
Minus strand

Genomic View for SIRPB1 Gene

Genes around SIRPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPB1 Gene

Proteins for SIRPB1 Gene

  • Protein details for SIRPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00241-SIRB1_HUMAN
    Recommended name:
    Signal-regulatory protein beta-1
    Protein Accession:
    O00241
    Secondary Accessions:
    • A6NLM2
    • B2R8V0
    • Q5TFQ9
    • Q5TFR0
    • Q8TB12
    • Q9H1U5
    • Q9Y4V0

    Protein attributes for SIRPB1 Gene

    Size:
    398 amino acids
    Molecular mass:
    43211 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

    Three dimensional structures from OCA and Proteopedia for SIRPB1 Gene

    Alternative splice isoforms for SIRPB1 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for SIRPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TFQ8-SIRBL_HUMAN
    Recommended name:
    Signal-regulatory protein beta-1 isoform 3
    Protein Accession:
    Q5TFQ8
    Secondary Accessions:
    • Q7Z3B9

    Protein attributes for SIRPB1 Gene

    Size:
    398 amino acids
    Molecular mass:
    43359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SIRPB1 Gene

    Alternative splice isoforms for SIRPB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPB1 Gene

Post-translational modifications for SIRPB1 Gene

Antibody Products

  • R&D Systems Antibodies for SIRPB1 (SIRP beta 1/CD172b)
  • Cloud-Clone Corp. Antibodies for SIRPB1

No data available for DME Specific Peptides for SIRPB1 Gene

Domains & Families for SIRPB1 Gene

Suggested Antigen Peptide Sequences for SIRPB1 Gene

Graphical View of Domain Structure for InterPro Entry

O00241

UniProtKB/Swiss-Prot:

SIRBL_HUMAN :
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPB1: view

Function for SIRPB1 Gene

Molecular function for SIRPB1 Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

Gene Ontology (GO) - Molecular Function for SIRPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10940905
genes like me logo Genes that share ontologies with SIRPB1: view
genes like me logo Genes that share phenotypes with SIRPB1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIRPB1 Gene

Localization for SIRPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPB1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPB1 Gene COMPARTMENTS Subcellular localization image for SIRPB1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIRPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9062191
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SIRPB1: view

Pathways & Interactions for SIRPB1 Gene

genes like me logo Genes that share pathways with SIRPB1: view

Pathways by source for SIRPB1 Gene

Gene Ontology (GO) - Biological Process for SIRPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9062191
GO:0007166 cell surface receptor signaling pathway TAS 9062191
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIRPB1: view

No data available for SIGNOR curated interactions for SIRPB1 Gene

Transcripts for SIRPB1 Gene

Unigene Clusters for SIRPB1 Gene

Signal-regulatory protein beta 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - -
SP2:
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for SIRPB1 Gene

GeneLoc Exon Structure for
SIRPB1
ECgene alternative splicing isoforms for
SIRPB1

Expression for SIRPB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPB1 Gene

This gene is overexpressed in Whole Blood (x43.8).

Protein differential expression in normal tissues from HIPED for SIRPB1 Gene

This gene is overexpressed in Brain (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIRPB1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SIRPB1 Gene:

SIRPB1

SOURCE GeneReport for Unigene cluster for SIRPB1 Gene:

Hs.664861

mRNA Expression by UniProt/SwissProt for SIRPB1 Gene:

O00241-SIRB1_HUMAN
Tissue specificity: Detected in monocytes and dendritic cells.
genes like me logo Genes that share expression patterns with SIRPB1: view

Primer Products

No data available for Protein tissue co-expression partners for SIRPB1 Gene

Orthologs for SIRPB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPB1 34
  • 96.73 (n)
-- 35
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SIRPB1 34 35
  • 81.15 (n)
SIRPA 35
  • 53 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC477182 34
  • 80.37 (n)
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia LOC100038947 34
  • 69.6 (n)
Sirpb1b 35
  • 58 (a)
ManyToMany
Sirpb1c 16 35
  • 57 (a)
Sirpb1a 35
  • 57 (a)
ManyToMany
Gm9733 35
  • 49 (a)
ManyToMany
Sirpa 35
  • 43 (a)
ManyToMany
Gm5150 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
Species where no ortholog for SIRPB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPB1 Gene

ENSEMBL:
Gene Tree for SIRPB1 (if available)
TreeFam:
Gene Tree for SIRPB1 (if available)

Paralogs for SIRPB1 Gene

Variants for SIRPB1 Gene

Sequence variations from dbSNP and Humsavar for SIRPB1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11087121 -- 1,580,611(+) gatgg(A/T)ataat intron-variant
rs111311541 -- 1,612,904(+) GGGAG(G/T)TGATG intron-variant
rs111353945 -- 1,578,470(+) GTCCA(G/T)GTTGT nc-transcript-variant, reference, missense
rs111393658 -- 1,604,706(+) GGTGG(C/T)CAGGT intron-variant
rs111403092 -- 1,566,156(+) ACAGT(C/G)AGGCC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, stop-lost

Structural Variations from Database of Genomic Variants (DGV) for SIRPB1 Gene

Variant ID Type Subtype PubMed ID
dgv1223e212 CNV loss 25503493
dgv1224e212 CNV loss 25503493
dgv1225e212 CNV gain 25503493
dgv161n111 CNV deletion 26073780
dgv2200n106 CNV deletion 24896259
dgv33n47 CNV loss 21111241
dgv39e213 CNV gain 24956385
dgv4223n100 CNV gain 25217958
dgv4224n100 CNV loss 25217958
dgv4225n100 CNV loss 25217958
dgv4226n100 CNV loss 25217958
dgv4227n100 CNV loss 25217958
dgv4228n100 CNV loss 25217958
dgv4229n100 CNV gain+loss 25217958
dgv4230n100 CNV gain 25217958
dgv4231n100 CNV gain 25217958
dgv4232n100 CNV loss 25217958
dgv4233n100 CNV gain+loss 25217958
dgv4234n100 CNV gain 25217958
dgv4235n100 CNV loss 25217958
dgv4236n100 CNV loss 25217958
dgv4237n100 CNV gain+loss 25217958
dgv4238n100 CNV loss 25217958
dgv4239n100 CNV loss 25217958
dgv691n67 CNV loss 20364138
dgv692n67 CNV loss 20364138
dgv7431n54 CNV loss 21841781
dgv7432n54 CNV loss 21841781
dgv7433n54 CNV gain 21841781
dgv7434n54 CNV loss 21841781
dgv7435n54 CNV loss 21841781
dgv7436n54 CNV loss 21841781
dgv774e199 CNV deletion 23128226
esv2421429 CNV duplication 20811451
esv2424715 CNV insertion 19546169
esv25111 CNV gain+loss 19812545
esv2556331 CNV deletion 19546169
esv2574735 CNV loss 19546169
esv2668708 CNV deletion 23128226
esv2671657 CNV deletion 23128226
esv2722071 CNV deletion 23290073
esv2722072 CNV deletion 23290073
esv2722074 CNV deletion 23290073
esv2758777 CNV gain+loss 17122850
esv2760679 CNV gain+loss 21179565
esv2763670 CNV loss 21179565
esv2956013 CNV deletion 24192839
esv33285 CNV gain+loss 17666407
esv3358008 CNV insertion 20981092
esv3371643 CNV insertion 20981092
esv33848 CNV loss 17666407
esv33908 CNV loss 17666407
esv3584420 CNV loss 25503493
esv3644980 CNV gain 21293372
esv3644982 CNV loss 21293372
esv3644983 CNV loss 21293372
esv3644984 CNV loss 21293372
esv3644985 CNV loss 21293372
esv3644986 CNV loss 21293372
esv7521 CNV loss 19470904
esv991867 CNV gain 20482838
esv995112 CNV deletion 20482838
nsv1055850 CNV gain+loss 25217958
nsv1057460 CNV loss 25217958
nsv1059730 CNV loss 25217958
nsv1062881 CNV gain 25217958
nsv1071672 CNV deletion 25765185
nsv1133499 CNV deletion 24896259
nsv1160672 CNV deletion 26073780
nsv1160675 OTHER complex 26073780
nsv184 CNV deletion 15895083
nsv3253 CNV deletion 18451855
nsv428374 CNV loss 18775914
nsv436327 CNV deletion 17901297
nsv437183 CNV loss 16327808
nsv438306 CNV loss 16468122
nsv442775 CNV loss 18776908
nsv442776 CNV loss 18776908
nsv510779 CNV deletion 20534489
nsv512601 CNV loss 21212237
nsv514932 CNV loss 21397061
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv585215 CNV loss 21841781
nsv585221 CNV loss 21841781
nsv585238 CNV gain 21841781
nsv585241 CNV loss 21841781
nsv821006 CNV deletion 20802225
nsv828665 CNV loss 20364138
nsv833894 CNV gain 17160897
nsv952972 CNV deletion 24416366
nsv952973 CNV deletion 24416366
nsv952974 CNV duplication 24416366
nsv962553 CNV duplication 23825009
nsv965840 CNV duplication 23825009
nsv965841 CNV duplication 23825009
nsv965842 CNV duplication 23825009
nsv9775 CNV loss 18304495
nsv9776 CNV gain+loss 18304495
nsv9777 CNV loss 18304495

Variation tolerance for SIRPB1 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPB1 Gene

Human Gene Mutation Database (HGMD)
SIRPB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRPB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPB1 Gene

Disorders for SIRPB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIRPB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
composite lymphoma
  • composite hodgkin and non-hodgkin lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIRPB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPB1
genes like me logo Genes that share disorders with SIRPB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRPB1 Gene

Publications for SIRPB1 Gene

  1. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. (PMID: 10604985) Dietrich J. … Colonna M. (J. Immunol. 2000) 3 22 64
  4. Association of signal-regulatory proteins beta with KARAP/DAP-12. (PMID: 10940905) Tomasello E. … Vivier E. (Eur. J. Immunol. 2000) 3 22 64
  5. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PMID: 9062191) Kharitonenkov A. … Ullrich A. (Nature 1997) 2 3 64

Products for SIRPB1 Gene

Sources for SIRPB1 Gene

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