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SIRPB1 Gene

protein-coding   GIFtS: 57
GCID: GC20M001544

Signal-Regulatory Protein Beta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal-Regulatory Protein Beta 11 2     Signal-Regulatory Protein Beta-12
CD172 Antigen-Like Family Member B2 3     SIRP-beta-13
CD172b2     CD172b Antigen3
SIRP-BETA-12     SIRP-Beta-1 Isoform 33

External Ids:    HGNC: 159281   Entrez Gene: 103262   Ensembl: ENSG000001013077   OMIM: 6038895   UniProtKB: O002413   
UniProtKB: Q5TFQ83   

Export aliases for SIRPB1 gene to outside databases

Previous GC identifers: GC20M001531 GC20M001538 GC20M001491 GC20M001495


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRPB1 Gene:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to
the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be
involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was
found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This
protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for SIRPB1 Gene:
SIRPB1 (signal-regulatory protein beta 1) is a protein-coding gene. Diseases associated with SIRPB1 include composite lymphoma, and schizophrenia. An important paralog of this gene is SIRPB2.

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8
Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine
kinase-coupled signaling processes (By similarity)

Gene Wiki entry for SIRPB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRPB1 gene promoter:
         HTF   SREBP-1c   Pax-6   NF-E2 p45   SREBP-1b   AREB6   Max   SREBP-1a   HOXA5   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRPB1 promoter sequence
   Search Chromatin IP Primers for SIRPB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SIRPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRPB1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001544:  view genomic region     (about GC identifiers)

Start:
1,544,167 bp from pter      End:
1,600,707 bp from pter
Size:
56,541 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241 (See protein sequence)
Recommended Name: Signal-regulatory protein beta-1 precursor  
Size: 398 amino acids; 43211 Da
Subunit: Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK
2 PDB 3D structures from and Proteopedia for SIRPB1:
2D9C (3D)        2JJU (3D)    
Secondary accessions: A6NLM2 B2R8V0 Q5TFQ9 Q5TFR0 Q8TB12 Q9H1U5 Q9Y4V0
Alternative splicing: 3 isoforms:  O00241-1   O00241-2   Q5TFQ8-1   (No experimental confirmation available)

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8 (See protein sequence)

Recommended Name: Signal-regulatory protein beta-1 isoform 3 precursor  
Size: 398 amino acids; 43359 Da
1 PDB 3D structure from and Proteopedia for SIRPB1:
2JJV (3D)    
Secondary accessions: Q7Z3B9
Alternative splicing: 3 isoforms:  Q5TFQ8-1   O00241-1   O00241-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRPB1: NX_Q5TFQ8

Explore proteomics data for SIRPB1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys182
  • Glycosylation2 at Asn244, Asn269, Asn291
  • Modification sites at PhosphoSitePlus

  • See SIRPB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001077379.1  NP_006056.2  NP_001129316.1  

    ENSEMBL proteins: 
     ENSP00000371018   ENSP00000371016   ENSP00000457323   ENSP00000456351   ENSP00000457829  
     ENSP00000456519   ENSP00000457458   ENSP00000457855   ENSP00000456747   ENSP00000455568  
     ENSP00000279477   ENSP00000456826   ENSP00000262929  
    Reactome Protein details: O00241

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIRP: Signal-regulatory proteins
    CD: CD molecules
    C1SET: Immunoglobulin superfamily / C1-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O00241
    Graphical View of Domain Structure for InterPro Entry Q5TFQ8

    ProtoNet protein and cluster: O00241

    2 Blocks protein domains:
    IPB003597 Immunoglobulin C-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241
    Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8
    Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIRPB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIRB1_HUMAN, O00241
    Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine
    kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK

         UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8
    Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine
    kinase-coupled signaling processes (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10940905
         
    SIRPB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIRPB1:
     Increased G2M DNA content 

    Animal Models:
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    1 qRT-PCR Assays for microRNA that regulate SIRPB1:
    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidSIRPB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIRB1_HUMAN, O00241: Membrane; Single-pass type I membrane protein
    SIRBL_HUMAN, Q5TFQ8: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9062191
    GO:0016021integral component of membrane IEA--

    SIRPB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIRPB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    Signal regulatory protein (SIRP) family interactions0.00
    2Signaling by FGFR
    DAP12 interactions0.89
    3Osteoclast differentiation
    Osteoclast differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SIRPB1
        Signal regulatory protein (SIRP) family interactions
    DAP12 interactions


    1 Kegg Pathway  (Kegg details for SIRPB1):
        Osteoclast differentiation


    SIRPB1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIRPB1
    Interactions:

        GeneGlobe Interaction Network for SIRPB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRPB1 (O002411 Q5TFQ81, 3 ENSP000002794774) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439141, ENSP000002626294EBI-2615458,EBI-2214794 STRING: ENSP00000262629
    CD47ENSP000003553614STRING: ENSP00000355361
    THPOENSP000002046154STRING: ENSP00000204615
    CD3EENSP000003545664STRING: ENSP00000354566
    SYKENSP000003648984STRING: ENSP00000364898
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9062191
    GO:0007166cell surface receptor signaling pathway TAS9062191
    GO:0045087innate immune response TAS--

    SIRPB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIRPB1 (SIRBL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIRPB1 gene (3 alternative transcripts): 
    NM_001083910.2  NM_006065.3  NM_001135844.2  

    Unigene Cluster for SIRPB1:

    Signal-regulatory protein beta 1
    Hs.664861  [show with all ESTs]
    Unigene Representative Sequence: Y10376
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381605(uc010gai.3 uc002wfk.4) ENST00000381603 ENST00000569629
    ENST00000563840 ENST00000565076 ENST00000565775 ENST00000569387 ENST00000566055
    ENST00000565087 ENST00000565230 ENST00000562014 ENST00000279477(uc002wfl.4)
    ENST00000568365 ENST00000381596 ENST00000262929
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SIRPB1:
    hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidSIRPB1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SIRPB1

    Additional mRNA sequence: 

    AK130124.1 AK289866.1 AK313517.1 BC025286.1 BC075835.1 BC131747.1 BX537992.1 Y10376.1 

    11 DOTS entries:

    DT.91728990  DT.95153159  DT.95349255  DT.448770  DT.100694210  DT.100038563  DT.91728993  DT.120838642 
    DT.99927024  DT.100651082  DT.120813916 

    Selected AceView cDNA sequences (see all 67):

    AK130124 BQ635330 BI756472 BQ635331 CD369292 AA709221 AL597487 BQ635329 
    CA748838 BM285386 BX537992 AI219993 BM993396 CD368713 AX747909 AI201145 
    AI088704 CD742880 AI939310 BX112477 BI823904 CA306410 BQ635328 BC025286 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -     -     -     -     -     -     -           -     -                     
    SP2:                                                                                                
    SP3:                                -                                                               
    SP4:                                -     -                                                         
    SP5:                                -     -     -                                                   


    ECgene alternative splicing isoforms for SIRPB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIRPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SIRPB1 Expression
    About this image


    SIRPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Monocytes Peripheral Blood
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             bone marrow   
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    SIRPB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRPB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664861

    UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241
    Tissue specificity: Detected in monocytes and dendritic cells


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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIRPB1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirpb1a5
    LOC1000389471
    signal-regulatory protein beta 1A5
    signal-regulatory protein beta 1-like1
    69.6(n)1
    61.26(a)1
      3 (3.59 cM)5
    1000389471  NM_001173459.21  NP_001166930.11 
     153718275 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    GL343515.1(139492-140536)


    ENSEMBL Gene Tree for SIRPB1 (if available)
    TreeFam Gene Tree for SIRPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIRPB1 gene
    SIRPB22  SIRPD2  SIRPG2  SIRPA2  ENSG000002608612  
    Selected SIMAP similar genes for SIRPB1 using alignment to 11 protein entries:     SIRB1_HUMAN (see all proteins) (see all similar genes):
    PTPNS1    SIRPA    SIRPG    HLA-DRB5    HLA DRB4    HLA-DRB4*0102
    MICA    SIRPB2    SIRPD    HLA-DQB    HLA-A    HLA
    HLA-A*0201V3    HLA-B    HLA-DRB4    HLA-C    HLA-DRB1    HFE

    SIRPB1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SIRPB1 (see all 6)
    PGOHUM00000262174 PGOHUM00000262176 PGOHUM00000262177 PGOHUM00000247422 PGOHUM00000247423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIRPB1 (see all 259)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116979871,2
    C,F,H--1544529(+) ccaggC/Tccatc 2 -- ds50013Minor allele frequency- T:0.06NA WA 240
    rs1874512701,2
    --1544589(+) AGAGCC/TAAACT 2 -- ds50010--------
    rs116980001,2
    C,F,H--1544683(+) ttgaaC/Gtctca 2 -- ds500110Minor allele frequency- G:0.03NS EA NA WA 660
    rs1441453151,2
    --1544760(+) CTACAC/TTTGTA 2 -- ds50010--------
    rs119064651,2
    C,F,A,H--1544843(+) attgaC/Atatgg 2 -- ds500113Minor allele frequency- A:0.02NS EA NA WA 1494
    rs798503941,2
    C,F--1544846(+) GACTAT/CGGAGA 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1925873541,2
    --1544878(+) TGCACA/TGTCAT 2 -- ds50010--------
    rs1849250391,2
    --1545028(+) ACAAGA/GTAGTT 2 -- ds50010--------
    rs1460137551,2
    --1545080(+) TGAAGC/GAGGGA 2 -- ut310--------
    rs1399204591,2
    --1545089(+) GAGAGC/TGGGAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SIRPB1 (1544167 - 1600707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIRPB1 (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722071CNV Deletion23290073
    esv995112CNV Deletion20482838
    esv2722074CNV Deletion23290073
    nsv436327CNV Deletion17901297
    esv2722072CNV Deletion23290073
    esv2668708CNV Deletion23128226
    esv2556331CNV Deletion19546169
    esv2671657CNV Deletion23128226
    dgv774e199CNV Deletion23128226
    nsv821006CNV Deletion20802225

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603889    OMIM disorders: --

    3 diseases for SIRPB1:    
    About MalaCards
    composite lymphoma    schizophrenia    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for SIRPB1:
    Composite lymphoma

    SIRPB1 for disorders           About GeneDecksing


    Export disorders for SIRPB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIRPB1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SIRPB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nomenclature for signal regulatory protein family members. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (J. Immunol. 2005)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    3. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PubMed id 9062191)1, 3 Kharitonenkov A....Ullrich A. (Nature 1997)
    4. Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. (PubMed id 10604985)1, 9 Dietrich J.... Colonna M. (J. Immunol. 2000)
    5. Association of signal-regulatory proteins beta with KARAP/DAP-12. (PubMed id 10940905)1, 9 Tomasello E.... Vivier E. (Eur. J. Immunol. 2000)
    6. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (Eur Arch Psychiatry Clin Neurosci 2009)
    9. Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimer's disease. (PubMed id 19893026)1 Gaikwad S....Neumann H. (Am. J. Pathol. 2009)
    10. Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)1 Martins-de-Souza D....Dias-Neto E. (J Neural Transm 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10326 HGNC: 15928 AceView: SIRPB1andPTPNS1L2 Ensembl:ENSG00000101307 euGenes: HUgn10326
    ECgene: SIRPB1 Kegg: 10326 H-InvDB: SIRPB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIRPB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SIRPB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIRPB1 gene:
    Search GeneIP for patents involving SIRPB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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