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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIRPB1 Gene

protein-coding GIFtS: 55
GCID: GC20M001544

signal-regulatory protein beta 1

Explore 2 diseases affiliated with
SIRPB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal-Regulatory Protein Beta 1¹ ²		Signal-Regulatory Protein Beta-1²
CD172b¹ ²		SIRP-Beta-1¹
SIRP-BETA-1¹ ²		CD172b Antigen³
CD172 Antigen-Like Family Member B² ³		SIRP-Beta-1 Isoform 3³

External Ids:	HGNC: 15928¹	Entrez Gene: 10326²	Ensembl: ENSG00000101307⁷	OMIM: 603889⁵	UniProtKB: O00241³
	UniProtKB: Q5TFQ8³

Export aliases for SIRPB1 gene to outside databases

Previous GC identifers: GC20M001531 GC20M001538 GC20M001491 GC20M001495

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRPB1:

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the

immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in

the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact

with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported

to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8

Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine

kinase-coupled signaling processes (By similarity)

Gene Wiki entry for SIRPB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIRPB1 gene promoter:
HTF SREBP-1c Pax-6 NF-E2 p45 SREBP-1b AREB6 Max SREBP-1a HOXA5 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIRPB1 promoter sequence

Search SABiosciences Chromatin IP Primers for SIRPB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

SIRPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRPB1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M001544: view genomic region (about GC identifiers)

Start:	1,544,167 bp from pter	End:	1,600,707 bp from pter
Size:	56,541 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241 (See protein sequence)

Recommended Name: Signal-regulatory protein beta-1 precursor

Size: 398 amino acids; 43211 Da

Subunit: Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK

Subcellular location: Membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for SIRPB1:

2D9C (3D)

2JJU (3D)

Secondary accessions: A6NLM2 B2R8V0 Q5TFQ9 Q5TFR0 Q8TB12 Q9H1U5 Q9Y4V0

Alternative splicing: 3 isoforms: O00241-1 O00241-2 Q5TFQ8-1 (No experimental confirmation available)

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8 (See protein sequence)

Recommended Name: Signal-regulatory protein beta-1 isoform 3 precursor

Size: 398 amino acids; 43359 Da

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for SIRPB1:

2JJV (3D)

Secondary accessions: Q7Z3B9

Alternative splicing: 3 isoforms: Q5TFQ8-1 O00241-1 O00241-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRPB1: NX_Q5TFQ8

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TFQ8

SIRPB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001077379.1 NP_006056.2 NP_001129316.1

ENSEMBL proteins:

ENSP00000371018 ENSP00000371016 ENSP00000457323 ENSP00000456351 ENSP00000457829

ENSP00000456519 ENSP00000457458 ENSP00000457855 ENSP00000456747 ENSP00000455568

ENSP00000279477 ENSP00000456826 ENSP00000262929

Reactome Protein details: O00241
Human Recombinant Protein Products for SIRPB1:

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	Novus Biologicals SIRPB1 Proteins Novus Biologicals SIRPB1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9062191
GO:0016021	integral to membrane	IEA	--

SIRPB1 for ontologies About GeneDecksing

SIRPB1 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIRPB1 for domains About GeneDecksing

5 InterPro domains/families:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry O00241

Graphical View of Domain Structure for InterPro Entry Q5TFQ8

ProtoNet protein and cluster: O00241

2 Blocks protein families:

IPB003597 Immunoglobulin C-type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241

Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8

Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIRB1_HUMAN, O00241

Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine

kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK

UniProtKB/Swiss-Prot: SIRBL_HUMAN, Q5TFQ8

Function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine

kinase-coupled signaling processes (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10940905

SIRPB1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SIRPB1:

Increased G2M DNA content

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SIRPB1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SIRPB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRPB1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate SIRPB1:
		hsa-miR-942
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPB1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Innate Immune System

0.46

Osteoclast differentiation

Osteoclast differentiation

1.00

Signal regulatory protein (SIRP) family interactions

Signal regulatory protein (SIRP) family interactions

1.00

Signaling by FGFR

DAP12 interactions

0.76

Cell-cell junction organization

Cell-Cell communication

0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for SIRPB1

	Signal regulatory protein (SIRP) family interactions
	DAP12 interactions
	Cell-Cell communication
	Immune System
	Innate Immune System

1 Kegg Pathway (Kegg details for SIRPB1):

Osteoclast differentiation

SIRPB1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIRPB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for SIRPB1 (O00241¹ Q5TFQ8^{1, 3} ENSP00000279477⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TYROBP	O43914¹, ENSP00000262629⁴	EBI-2615458,EBI-2214794 STRING: ENSP00000262629
CD47	ENSP00000355361⁴	STRING: ENSP00000355361
THPO	ENSP00000204615⁴	STRING: ENSP00000204615
CD3E	ENSP00000354566⁴	STRING: ENSP00000354566
SYK	ENSP00000364898⁴	STRING: ENSP00000364898

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9062191
GO:0007166	cell surface receptor signaling pathway	TAS	9062191

SIRPB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIRPB1
Search CenterWatch for drugs/clinical trials and news about SIRPB1 / SIRBL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIRPB1 gene (3 alternative transcripts):

NM_001083910.2 NM_006065.3 NM_001135844.2

Unigene Cluster for SIRPB1:

Signal-regulatory protein beta 1

Hs.664861 [show with all ESTs]

Unigene Representative Sequence: Y10376

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381605(uc010gai.3 uc002wfk.4) ENST00000381603 ENST00000569629

ENST00000563840 ENST00000565076 ENST00000565775 ENST00000569387 ENST00000566055

ENST00000565087 ENST00000565230 ENST00000562014 ENST00000279477(uc002wfl.4)

ENST00000568365 ENST00000381596 ENST00000262929

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SIRPB1 Browse OriGene MicroRNA Expression Plasmids
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		1 QIAGEN miScript miRNA Assays for microRNA that regulate SIRPB1:
		hsa-miR-942
		SwitchGear 3'UTR luciferase reporter plasmid: SIRPB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK130124.1 AK289866.1 AK313517.1 BC025286.1 BC075835.1 BC131747.1 BX537992.1 Y10376.1

11 DOTS entries:

DT.91728990 DT.95153159 DT.95349255 DT.448770 DT.100694210 DT.100038563 DT.91728993 DT.120838642

DT.99927024 DT.100651082 DT.120813916

24/67 AceView cDNA sequences (see all 67):

BM285386 BI756472 AK130124 AA709221 BQ635330 CD369292 CA748838 AL597487

BQ635329 BQ635331 AI088704 CD742880 BX537992 BI826712 BC025286 AA315922

CA306410 AX747909 BI518525 BQ027400 BI909139 BI823904 BI908893 BX112477

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:							-		-		-		-		-		-		-				-		-
SP2:
SP3:											-
SP4:											-		-
SP5:											-		-		-

ECgene alternative splicing isoforms for SIRPB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIRPB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SIRPB1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SIRPB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRPB1

SOURCE GeneReport for Unigene cluster: Hs.664861

UniProtKB/Swiss-Prot: SIRB1_HUMAN, O00241

Tissue specificity: Detected in monocytes and dendritic cells

SABiosciences Custom PCR Arrays for SIRPB1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB1 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SIRPA⁶ SIRPA⁶	Uncharacterized protein	34(a) 26(a)	many ↔ many many ↔ many	20(9775303-9777070) 20(9755182-9762138)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	29(a) 27(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343401.1(274297-334265) GL343515.1(82799-91211)

ENSEMBL Gene Tree for SIRPB1 (if available)
TreeFam Gene Tree for SIRPB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIRPB1 gene

SIRPB2² SIRPD² ENSG00000260861² SIRPA² SIRPG²

18/23 SIMAP similar genes for SIRPB1 using alignment to 11 protein entries: SIRB1_HUMAN (see all proteins) (see all similar genes):

PTPNS1 SIRPA SIRPG HLA-DRB5 HLA DRB4 HLA-DRB4*0102

MICA SIRPD HLA-DQB HLA-A HLA HLA-A*0201V3

HLA-B HLA-DRB4 HLA-C SIRPB2 HLA-DRB1 HFE

SIRPB1 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for SIRPB1 (see all 6)
PGOHUM00000262174 PGOHUM00000262176 PGOHUM00000262177 PGOHUM00000247422 PGOHUM00000247423

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11697987^1,2	C,H	--	1544529(+)	`ccaggC/Tccatc`	2	--	ds500¹		3		NA WA	240
rs187451270^1,2		--	1544589(+)	`AGAGCC/TAAACT`	2	--	ds500¹		0	--	--	--	--
rs11698000^1,2	C,F,H	--	1544683(+)	`TTGAAC/GTCTCA`	2	--	ds500¹		10		NS EA NA WA	660
rs144145315^1,2		--	1544760(+)	`CTACAC/TTTGTA`	2	--	ds500¹		0	--	--	--	--
rs11906465^1,2	C,F,A,H	--	1544843(+)	`attgaC/Atatgg`	2	--	ds500¹		13		NS EA NA WA	1494
rs79850394^1,2		--	1544846(+)	`GACTAT/CGGAGA`	2	--	ds500¹		1		WA	118
rs192587354^1,2		--	1544878(+)	`TGCACA/TGTCAT`	2	--	ds500¹		0	--	--	--	--
rs184925039^1,2		--	1545028(+)	`ACAAGA/GTAGTT`	2	--	ds500¹		0	--	--	--	--
rs146013755^1,2		--	1545080(+)	`TGAAGC/GAGGGA`	2	--	ut3¹		0	--	--	--	--
rs139920459^1,2		--	1545089(+)	`GAGAGC/TGGGAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIRPB1 (1544167 - 1600707 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 38 variations for SIRPB1
15/37 CNVs (see all 37): 35900 67634 37839 90435 7299 1522 4090 79098 90431 61903 102897 67635 35904 35902 31029
1 Indel: 102896

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIRPB1 for disorders           About GeneDecksing

OMIM gene information: 603889    OMIM disorders: --

2 diseases for SIRPB1:    About MalaCards

alzheimer's disease schizophrenia

1 disease from the University of Copenhagen DISEASES database for SIRPB1:

Composite lymphoma

Export disorders for SIRPB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SIRPB1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SIRPB1)

Utopia: connect your pdf to the dynamic
world of online information

A nomenclature for signal regulatory protein family m embers. (PubMed id 16339511)^{1, 3} van den Berg T.K....Barclay A.N. (2005)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
A family of proteins that inhibit signalling through tyrosine kinase receptors. (PubMed id 9062191)^{1, 3} Kharitonenkov A....Ullrich A. (1997)
Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. (PubMed id 10604985)^{1, 9} Dietrich J.... Colonna M. (2000)
Association of signal-regulatory proteins beta with KARAP/DAP-12. (PubMed id 10940905)^{1, 9} Tomasello E.... Vivier E. (2000)
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)¹ Martins-de-Souza D....Turck C.W. (2009)
Signal regulatory protein-beta1: a microglial modulat or of phagocytosis in Alzheimer's disease. (PubMed id 19893026)¹ Gaikwad S....Neumann H. (2009)
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. (PubMed id 18657508)² Hatherley D....Barclay A.N. (2008)
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)¹ Martins-de-Souza D....Dias-Neto E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10326	HGNC: 15928	AceView: SIRPB1andPTPNS1L2	Ensembl:ENSG00000101307	euGenes: HUgn10326
ECgene: SIRPB1	Kegg: 10326	H-InvDB: SIRPB1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIRPB1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SIRPB1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SIRPB1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SIRPB1 gene:
Search GeneIP for patents involving SIRPB1

GeneCards and IP:
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