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Aliases for SIRPB1 Gene

Aliases for SIRPB1 Gene

  • Signal Regulatory Protein Beta 1 2 3
  • Signal-Regulatory Protein Beta 1 2 3 5
  • CD172 Antigen-Like Family Member B 3 4
  • SIRP-BETA-1 3 4
  • SIRP-Beta-1 Isoform 3 4
  • CD172b Antigen 4
  • CD172b 3

External Ids for SIRPB1 Gene

Previous GeneCards Identifiers for SIRPB1 Gene

  • GC20M001531
  • GC20M001538
  • GC20M001491
  • GC20M001544
  • GC20M001495

Summaries for SIRPB1 Gene

Entrez Gene Summary for SIRPB1 Gene

  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for SIRPB1 Gene

SIRPB1 (Signal Regulatory Protein Beta 1) is a Protein Coding gene. Among its related pathways are Immune System and Osteoclast differentiation. An important paralog of this gene is SIRPA.

UniProtKB/Swiss-Prot for SIRPB1 Gene

  • Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

  • Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.

Gene Wiki entry for SIRPB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPB1 Gene

Genomics for SIRPB1 Gene

Regulatory Elements for SIRPB1 Gene

Genomic Location for SIRPB1 Gene

Chromosome:
20
Start:
1,563,521 bp from pter
End:
1,626,497 bp from pter
Size:
62,977 bases
Orientation:
Minus strand

Genomic View for SIRPB1 Gene

Genes around SIRPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPB1 Gene

Proteins for SIRPB1 Gene

  • Protein details for SIRPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00241-SIRB1_HUMAN
    Recommended name:
    Signal-regulatory protein beta-1
    Protein Accession:
    O00241
    Secondary Accessions:
    • A6NLM2
    • B2R8V0
    • Q5TFQ9
    • Q5TFR0
    • Q8TB12
    • Q9H1U5
    • Q9Y4V0

    Protein attributes for SIRPB1 Gene

    Size:
    398 amino acids
    Molecular mass:
    43211 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

    Three dimensional structures from OCA and Proteopedia for SIRPB1 Gene

    Alternative splice isoforms for SIRPB1 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for SIRPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TFQ8-SIRBL_HUMAN
    Recommended name:
    Signal-regulatory protein beta-1 isoform 3
    Protein Accession:
    Q5TFQ8
    Secondary Accessions:
    • Q7Z3B9

    Protein attributes for SIRPB1 Gene

    Size:
    398 amino acids
    Molecular mass:
    43359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SIRPB1 Gene

    Alternative splice isoforms for SIRPB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPB1 Gene

Proteomics data for SIRPB1 Gene at MOPED

Post-translational modifications for SIRPB1 Gene

Antibody Products

  • R&D Systems Antibodies for SIRPB1 (SIRP beta 1/CD172b)

No data available for DME Specific Peptides for SIRPB1 Gene

Domains & Families for SIRPB1 Gene

Protein Domains for SIRPB1 Gene

Suggested Antigen Peptide Sequences for SIRPB1 Gene

Graphical View of Domain Structure for InterPro Entry

O00241

UniProtKB/Swiss-Prot:

SIRBL_HUMAN :
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPB1: view

Function for SIRPB1 Gene

Molecular function for SIRPB1 Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.
UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
genes like me logo Genes that share phenotypes with SIRPB1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIRPB1 Gene

Localization for SIRPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPB1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPB1 Gene COMPARTMENTS Subcellular localization image for SIRPB1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIRPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SIRPB1: view

Pathways & Interactions for SIRPB1 Gene

genes like me logo Genes that share pathways with SIRPB1: view

Pathways by source for SIRPB1 Gene

Gene Ontology (GO) - Biological Process for SIRPB1 Gene

None

No data available for SIGNOR curated interactions for SIRPB1 Gene

Drugs & Compounds for SIRPB1 Gene

No Compound Related Data Available

Transcripts for SIRPB1 Gene

Unigene Clusters for SIRPB1 Gene

Signal-regulatory protein beta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - -
SP2:
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -

Relevant External Links for SIRPB1 Gene

GeneLoc Exon Structure for
SIRPB1
ECgene alternative splicing isoforms for
SIRPB1

Expression for SIRPB1 Gene

mRNA expression in normal human tissues for SIRPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPB1 Gene

This gene is overexpressed in Whole Blood (x43.8).

Protein differential expression in normal tissues from HIPED for SIRPB1 Gene

This gene is overexpressed in Brain (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIRPB1 Gene



SOURCE GeneReport for Unigene cluster for SIRPB1 Gene Hs.664861

mRNA Expression by UniProt/SwissProt for SIRPB1 Gene

O00241-SIRB1_HUMAN
Tissue specificity: Detected in monocytes and dendritic cells.
genes like me logo Genes that share expression patterns with SIRPB1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SIRPB1 Gene

Orthologs for SIRPB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPB1 35
  • 96.73 (n)
  • 95.72 (a)
-- 36
  • 60 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SIRPB1 35
  • 81.15 (n)
  • 73.26 (a)
-- 36
  • 43 (a)
ManyToMany
SIRPA 36
  • 53 (a)
ManyToMany
SIRPB1 36
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
LOC477182 35
  • 80.37 (n)
  • 73.15 (a)
mouse
(Mus musculus)
Mammalia Sirpb1c 16
LOC100038947 35
  • 69.6 (n)
  • 61.26 (a)
Gm5150 36
  • 29 (a)
ManyToMany
Gm9733 36
  • 49 (a)
ManyToMany
Sirpa 36
  • 43 (a)
ManyToMany
Sirpb1a 36
  • 57 (a)
ManyToMany
Sirpb1b 36
  • 58 (a)
ManyToMany
Sirpb1c 36
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
Species with no ortholog for SIRPB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPB1 Gene

ENSEMBL:
Gene Tree for SIRPB1 (if available)
TreeFam:
Gene Tree for SIRPB1 (if available)

Paralogs for SIRPB1 Gene

Paralogs for SIRPB1 Gene

genes like me logo Genes that share paralogs with SIRPB1: view

Variants for SIRPB1 Gene

Sequence variations from dbSNP and Humsavar for SIRPB1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1535882 -, - 1,619,878(+) GAGTC(C/T)CCCCA nc-transcript-variant, reference, missense
rs2746603 - 1,578,613(+) CACAG(C/T)GCAGA nc-transcript-variant, reference, missense
rs2253427 - 1,571,784(+) TGGGC(C/T)ATCTC intron-variant, nc-transcript-variant, reference, missense
rs2243603 - 1,566,265(+) CGCTG(C/G)TTCTG nc-transcript-variant, reference, missense
rs1135196 - 1,611,638(-) GGCCA(C/T)TCTGC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIRPB1 Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
dgv1301e1 CNV Complex 17122850
dgv1302e1 CNV Complex 17122850
nsv428374 CNV Loss 18775914
dgv4516n71 CNV Gain 21882294
nsv510779 CNV Loss 20534489
nsv833894 CNV Gain 17160897
nsv9775 CNV Loss 18304495
esv2424715 CNV Insertion 19546169
esv33848 CNV Loss 17666407
esv2722071 CNV Deletion 23290073
esv270432 CNV Insertion 20981092
esv272311 CNV Insertion 20981092
nsv437183 CNV Loss 16327808
nsv3253 CNV Loss 18451855
nsv184 CNV Loss 15895083
nsv821006 CNV Deletion 20802225
nsv828665 CNV Loss 20364138
esv25111 CNV Gain+Loss 19812545
esv2668708 CNV Deletion 23128226
dgv774e199 CNV Deletion 23128226
dgv33n47 CNV Loss 21111241
esv2421429 CNV Duplication 20811451
nsv442775 CNV CNV 18776908
esv2671657 CNV Deletion 23128226
esv33285 CNV Gain+Loss 17666407
nsv512601 CNV Loss 21212237
esv2556331 CNV Deletion 19546169
esv995112 CNV Deletion 20482838
nsv436327 CNV Deletion 17901297
esv991867 CNV Gain 20482838
esv7521 CNV Loss 19470904
esv2722072 CNV Deletion 23290073
nsv442776 CNV CNV 18776908
esv2574735 CNV Loss 19546169
nsv9776 CNV Gain+Loss 18304495
dgv691n67 CNV Loss 20364138
nsv514932 CNV Loss 21397061
nsv438306 CNV Loss 16468122
dgv692n67 CNV Loss 20364138
nsv9777 CNV Loss 18304495
esv2722074 CNV Deletion 23290073
esv33908 CNV Loss 17666407

Variation tolerance for SIRPB1 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPB1 Gene

HapMap Linkage Disequilibrium report
SIRPB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPB1 Gene

Disorders for SIRPB1 Gene

Relevant External Links for SIRPB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPB1

No disorders were found for SIRPB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPB1 Gene

Publications for SIRPB1 Gene

  1. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3 67
  2. Association of signal-regulatory proteins beta with KARAP/DAP-12. (PMID: 10940905) Tomasello E. … Vivier E. (Eur. J. Immunol. 2000) 3 23
  3. Signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. (PMID: 10604985) Dietrich J. … Colonna M. (J. Immunol. 2000) 3 23
  4. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PMID: 9062191) Kharitonenkov A. … Ullrich A. (Nature 1997) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SIRPB1 Gene

Sources for SIRPB1 Gene

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