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Aliases for SIRPA Gene

Aliases for SIRPA Gene

  • Signal Regulatory Protein Alpha 2 3 5
  • CD172 Antigen-Like Family Member A 3 4
  • Inhibitory Receptor SHPS-1 3 4
  • Macrophage Fusion Receptor 3 4
  • PTPNS1 3 4
  • SHPS1 3 4
  • SIRP 3 4
  • P84 3 4
  • BIT 3 4
  • MFR 3 4
  • Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs 3
  • Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1 2
  • Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 3
  • Tyrosine Phosphatase SHP Substrate 1 3
  • Signal-Regulatory Protein Alpha-1 4
  • Signal-Regulatory Protein Alpha-2 4
  • Signal-Regulatory Protein Alpha-3 4
  • Signal-Regulatory Protein Alpha 2
  • SHP Substrate 1 4
  • CD172a Antigen 4
  • Myd-1 Antigen 3
  • MyD-1 Antigen 4
  • Sirp-Alpha-1 4
  • Sirp-Alpha-2 4
  • Sirp-Alpha-3 4
  • CD172A 3
  • SHPS-1 4
  • MYD-1 3
  • MYD1 4

External Ids for SIRPA Gene

Previous HGNC Symbols for SIRPA Gene

  • PTPNS1

Previous GeneCards Identifiers for SIRPA Gene

  • GC20P001822

Summaries for SIRPA Gene

Entrez Gene Summary for SIRPA Gene

  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPA Gene

SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Bladder Neck Obstruction and Autoimmune Hemolytic Anemia. Among its related pathways are Cell junction organization and Adhesion. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.

UniProtKB/Swiss-Prot for SIRPA Gene

  • Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Gene Wiki entry for SIRPA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPA Gene

Genomics for SIRPA Gene

Regulatory Elements for SIRPA Gene

Enhancers for SIRPA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G001808 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.1 -82.6 -82583 6.6 ELF3 ARID4B SIN3A DMAP1 RAD21 RARA YY1 GATA2 ZNF366 HSF1 ENSG00000230839 SIRPA SDCBP2 PDYN SIRPB2 LOC100289473
GH20G001843 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -49.3 -49329 2.8 HDGF PKNOX1 GATA2 ZNF143 RELB IKZF2 CREM CEBPB ZNF623 TBX21 SIRPA PSMF1 SIRPB2 SIRPB1 ENSG00000230839 PIR58932
GH20G001870 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -20.5 -20466 6.5 HDGF PKNOX1 FOXA2 ZFP64 SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF207 SIRPA SIRPB2 SNPH LOC100289473 SIRPB1 NSFL1C PIR58932 ENSG00000230839
GH20G001827 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 -64.5 -64515 4.7 FOXA2 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS SP5 MXD4 SIRPA ZNF343 PDYN SDCBP2 ENSG00000230839 PIR58932
GH20G001815 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -73.2 -73164 11.5 YBX1 ZNF48 GATA2 CBX5 ZNF143 FOS ZNF263 JUNB MIER2 ZNF623 SDCBP2 SIRPB2 SIRPB1 SIRPA ZNF343 LOC100533711 NSFL1C ENSG00000230839 PIR58932
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRPA on UCSC Golden Path with GeneCards custom track

Promoters for SIRPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133616 1183 3401 DMAP1 ZNF48 YY1 GLIS2 ZNF143 FOS MIER3 RFX3 GLIS1 RCOR2

Genomic Location for SIRPA Gene

Chromosome:
20
Start:
1,894,117 bp from pter
End:
1,940,592 bp from pter
Size:
46,476 bases
Orientation:
Plus strand

Genomic View for SIRPA Gene

Genes around SIRPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPA Gene

Proteins for SIRPA Gene

  • Protein details for SIRPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78324-SHPS1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type substrate 1
    Protein Accession:
    P78324
    Secondary Accessions:
    • A2A2E1
    • A8K411
    • B2R6C3
    • O00683
    • O43799
    • Q8N517
    • Q8TAL8
    • Q9H0Z2
    • Q9UDX2
    • Q9UIJ6
    • Q9Y4U9

    Protein attributes for SIRPA Gene

    Size:
    504 amino acids
    Molecular mass:
    54967 Da
    Quaternary structure:
    • Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

    Three dimensional structures from OCA and Proteopedia for SIRPA Gene

    Alternative splice isoforms for SIRPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPA Gene

Post-translational modifications for SIRPA Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SIRPA (SIRP alpha/CD172a)
  • Cell Signaling Technology (CST) Antibodies for SIRPA (SHPS1)
  • Cloud-Clone Corp. Antibodies for SIRPA

No data available for DME Specific Peptides for SIRPA Gene

Domains & Families for SIRPA Gene

Suggested Antigen Peptide Sequences for SIRPA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIRPA: view

No data available for UniProtKB/Swiss-Prot for SIRPA Gene

Function for SIRPA Gene

Molecular function for SIRPA Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Gene Ontology (GO) - Molecular Function for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SIRPA: view
genes like me logo Genes that share phenotypes with SIRPA: view

Animal Models for SIRPA Gene

MGI Knock Outs for SIRPA:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRPA Gene

Localization for SIRPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRPA gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9062191
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0070821 tertiary granule membrane TAS --
genes like me logo Genes that share ontologies with SIRPA: view

Pathways & Interactions for SIRPA Gene

genes like me logo Genes that share pathways with SIRPA: view

SIGNOR curated interactions for SIRPA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9070220
GO:0043312 neutrophil degranulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SIRPA: view

Drugs & Compounds for SIRPA Gene

(7) Drugs for SIRPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SIRPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIRPA: view

Transcripts for SIRPA Gene

Unigene Clusters for SIRPA Gene

Signal-regulatory protein alpha:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPA Gene

No ASD Table

Relevant External Links for SIRPA Gene

GeneLoc Exon Structure for
SIRPA
ECgene alternative splicing isoforms for
SIRPA

Expression for SIRPA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPA Gene

This gene is overexpressed in Whole Blood (x5.7) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SIRPA Gene

This gene is overexpressed in Brain (22.5), Frontal cortex (19.7), and Cerebrospinal fluid (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIRPA Gene



NURSA nuclear receptor signaling pathways regulating expression of SIRPA Gene:

SIRPA

SOURCE GeneReport for Unigene cluster for SIRPA Gene:

Hs.581021

mRNA Expression by UniProt/SwissProt for SIRPA Gene:

P78324-SHPS1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for SIRPA Gene

  • Nervous system(4.9)
  • Blood(4.6)
  • Skin(4.6)
  • Bone marrow(4.5)
  • Kidney(4.4)
  • Liver(4.3)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Lung(2.4)
  • Muscle(2.3)
  • Intestine(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with SIRPA: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRPA Gene

Orthologs for SIRPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPA 34 35
  • 98.75 (n)
-- 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SIRPA 34
  • 85 (n)
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SIRPA 34 35
  • 83.63 (n)
SIRPB1 35
  • 66 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sirpa 34
  • 75.32 (n)
mouse
(Mus musculus)
Mammalia Sirpa 34 16 35
  • 74.37 (n)
Sirpb1a 35
  • 56 (a)
ManyToMany
Sirpb1b 35
  • 56 (a)
ManyToMany
Sirpb1c 35
  • 56 (a)
ManyToMany
Gm9733 35
  • 46 (a)
ManyToMany
Gm5150 35
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC771734 34
  • 57.79 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
Species where no ortholog for SIRPA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPA Gene

ENSEMBL:
Gene Tree for SIRPA (if available)
TreeFam:
Gene Tree for SIRPA (if available)

Paralogs for SIRPA Gene

Paralogs for SIRPA Gene

(3) SIMAP similar genes for SIRPA Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIRPA Gene

genes like me logo Genes that share paralogs with SIRPA: view

Variants for SIRPA Gene

Sequence variations from dbSNP and Humsavar for SIRPA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000154217 -- 1,897,439(+) GTCAC(A/G)CCATG intron-variant
rs1000207828 -- 1,897,205(+) AAAAC(A/G)GTCTA intron-variant
rs1000211340 -- 1,936,261(+) GCAGG(G/T)TGATA intron-variant
rs1000309633 -- 1,904,387(+) AGGCC(C/T)CACCT intron-variant
rs1000406018 -- 1,907,834(+) ACTGT(A/G)TAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPA Gene

Variant ID Type Subtype PubMed ID
dgv7437n54 CNV loss 21841781
esv1005896 CNV gain 20482838
esv25632 CNV gain+loss 19812545
esv2722081 CNV deletion 23290073
esv2722082 CNV deletion 23290073
esv2722083 CNV deletion 23290073
esv2722085 CNV deletion 23290073
nsv3257 CNV insertion 18451855
nsv473862 CNV novel sequence insertion 20440878
nsv475546 CNV novel sequence insertion 20440878
nsv511629 CNV loss 21212237
nsv585258 CNV loss 21841781
nsv585259 CNV loss 21841781
nsv585260 CNV loss 21841781
nsv585261 CNV loss 21841781
nsv964370 CNV duplication 23825009
nsv979411 CNV duplication 23825009

Variation tolerance for SIRPA Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.36; 99.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPA Gene

Human Gene Mutation Database (HGMD)
SIRPA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPA Gene

Disorders for SIRPA Gene

MalaCards: The human disease database

(11) MalaCards diseases for SIRPA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder neck obstruction
  • obstruction of bladder neck or vesicourethral orifice
autoimmune hemolytic anemia
  • autoimmune haemolytic anaemia
thoracic outlet syndrome
  • tos - thoracic outlet syndrome
amblyopia
suppression amblyopia
  • strabismic amblyopia
- elite association - COSMIC cancer census association via MalaCards
Search SIRPA in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIRPA

Genetic Association Database (GAD)
SIRPA
Human Genome Epidemiology (HuGE) Navigator
SIRPA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPA
genes like me logo Genes that share disorders with SIRPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRPA Gene

Publications for SIRPA Gene

  1. Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. (PMID: 9070220) Yamao T. … Kasuga M. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
  2. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. (PMID: 10842184) Stofega M.R. … Carter-Su C. (J. Biol. Chem. 2000) 3 4 22 64
  3. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. (PMID: 10469599) Timms J.F. … Neel B.G. (Curr. Biol. 1999) 3 4 22 64
  4. Gene structure of mouse BIT/SHPS-1. (PMID: 10585853) Sano S. … Kubota M. (Biochem. J. 1999) 3 4 22 64
  5. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PMID: 9062191) Kharitonenkov A. … Ullrich A. (Nature 1997) 2 3 4 64

Products for SIRPA Gene

Sources for SIRPA Gene

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