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Aliases for SIRPA Gene

Aliases for SIRPA Gene

  • Signal-Regulatory Protein Alpha 2 3
  • CD172 Antigen-Like Family Member A 3 4
  • Inhibitory Receptor SHPS-1 3 4
  • Macrophage Fusion Receptor 3 4
  • PTPNS1 3 4
  • SHPS1 3 4
  • SIRP 3 4
  • P84 3 4
  • BIT 3 4
  • MFR 3 4
  • Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs 3
  • Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1 2
  • Tyrosine Phosphatase SHP Substrate 1 3
  • Signal-Regulatory Protein Alpha-1 4
  • Signal-Regulatory Protein Alpha-2 4
  • Signal-Regulatory Protein Alpha-3 4
  • SHP Substrate 1 4
  • CD172a Antigen 4
  • Myd-1 Antigen 3
  • MyD-1 Antigen 4
  • Sirp-Alpha-1 4
  • Sirp-Alpha-2 4
  • Sirp-Alpha-3 4
  • CD172A 3
  • SHPS-1 4
  • MYD-1 3
  • MYD1 4

External Ids for SIRPA Gene

Previous HGNC Symbols for SIRPA Gene

  • PTPNS1

Previous GeneCards Identifiers for SIRPA Gene

  • GC20P001822

Summaries for SIRPA Gene

Entrez Gene Summary for SIRPA Gene

  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPA Gene

SIRPA (Signal-Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include bladder neck obstruction and thoracic outlet syndrome. Among its related pathways are Tyrosine Kinases / Adaptors and Hemostasis. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.

UniProtKB/Swiss-Prot for SIRPA Gene

  • Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Gene Wiki entry for SIRPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPA Gene

Genomics for SIRPA Gene

Regulatory Elements for SIRPA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIRPA Gene

Chromosome:
20
Start:
1,894,117 bp from pter
End:
1,940,592 bp from pter
Size:
46,476 bases
Orientation:
Plus strand

Genomic View for SIRPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPA Gene

Proteins for SIRPA Gene

  • Protein details for SIRPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78324-SHPS1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type substrate 1
    Protein Accession:
    P78324
    Secondary Accessions:
    • A2A2E1
    • A8K411
    • B2R6C3
    • O00683
    • O43799
    • Q8N517
    • Q8TAL8
    • Q9H0Z2
    • Q9UDX2
    • Q9UIJ6
    • Q9Y4U9

    Protein attributes for SIRPA Gene

    Size:
    504 amino acids
    Molecular mass:
    54967 Da
    Quaternary structure:
    • Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.

    Three dimensional structures from OCA and Proteopedia for SIRPA Gene

    Alternative splice isoforms for SIRPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPA Gene

Proteomics data for SIRPA Gene at MOPED

Post-translational modifications for SIRPA Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIRPA Gene

Antibody Products

  • R&D Systems Antibodies for SIRPA (SIRP alpha/CD172a)
  • Cell Signaling Technology (CST) Antibodies for SIRPA (SHPS1)

No data available for DME Specific Peptides for SIRPA Gene

Domains & Families for SIRPA Gene

Protein Domains for SIRPA Gene

Suggested Antigen Peptide Sequences for SIRPA Gene

Graphical View of Domain Structure for InterPro Entry

P78324

UniProtKB/Swiss-Prot:

SHPS1_HUMAN :
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPA: view

Function for SIRPA Gene

Molecular function for SIRPA Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Gene Ontology (GO) - Molecular Function for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SIRPA: view
genes like me logo Genes that share phenotypes with SIRPA: view

Animal Models for SIRPA Gene

MGI Knock Outs for SIRPA:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SIRPA Gene

Localization for SIRPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPA Gene COMPARTMENTS Subcellular localization image for SIRPA gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9062191
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SIRPA: view

Pathways & Interactions for SIRPA Gene

genes like me logo Genes that share pathways with SIRPA: view

SIGNOR curated interactions for SIRPA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9070220
GO:0007596 blood coagulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SIRPA: view

Drugs & Compounds for SIRPA Gene

(6) Drugs for SIRPA Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 540
Calcium Nutra 0
Inositol Nutra 65
phenylalanine Nutra 130
serine Nutra 420

(4) Additional Compounds for SIRPA Gene - From: NovoSeek

genes like me logo Genes that share compounds with SIRPA: view

Transcripts for SIRPA Gene

Unigene Clusters for SIRPA Gene

Signal-regulatory protein alpha:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPA Gene

No ASD Table

Relevant External Links for SIRPA Gene

GeneLoc Exon Structure for
SIRPA
ECgene alternative splicing isoforms for
SIRPA

Expression for SIRPA Gene

mRNA expression in normal human tissues for SIRPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPA Gene

This gene is overexpressed in Whole Blood (x5.7) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SIRPA Gene

This gene is overexpressed in Brain (22.5), Frontal cortex (19.7), and Cerebrospinal fluid (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIRPA Gene



SOURCE GeneReport for Unigene cluster for SIRPA Gene Hs.581021

mRNA Expression by UniProt/SwissProt for SIRPA Gene

P78324-SHPS1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas
genes like me logo Genes that share expression patterns with SIRPA: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SIRPA Gene

Orthologs for SIRPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIRPA 35
  • 83.63 (n)
  • 76.74 (a)
-- 36
  • 39 (a)
ManyToMany
SIRPA 36
  • 76 (a)
ManyToMany
SIRPB1 36
  • 66 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SIRPA 35
  • 85 (n)
  • 79.2 (a)
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sirpa 35
  • 74.37 (n)
  • 66.14 (a)
Sirpa 16
Gm5150 36
  • 29 (a)
ManyToMany
Gm9733 36
  • 46 (a)
ManyToMany
Sirpa 36
  • 66 (a)
ManyToMany
Sirpb1a 36
  • 56 (a)
ManyToMany
Sirpb1b 36
  • 56 (a)
ManyToMany
Sirpb1c 36
  • 56 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SIRPA 35
  • 98.75 (n)
  • 98.54 (a)
-- 36
  • 80 (a)
OneToMany
SIRPA 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sirpa 35
  • 75.32 (n)
  • 66.47 (a)
chicken
(Gallus gallus)
Aves LOC771734 35
  • 57.79 (n)
  • 46.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
Species with no ortholog for SIRPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPA Gene

ENSEMBL:
Gene Tree for SIRPA (if available)
TreeFam:
Gene Tree for SIRPA (if available)

Paralogs for SIRPA Gene

Paralogs for SIRPA Gene

(3) SIMAP similar genes for SIRPA Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIRPA Gene

genes like me logo Genes that share paralogs with SIRPA: view

Variants for SIRPA Gene

Sequence variations from dbSNP and Humsavar for SIRPA Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs742618 -- 1,922,952(+) TGTCA(C/T)GCTCC intron-variant
rs754829 -- 1,906,938(-) TCAGA(G/T)GCTCT intron-variant
rs1008829 -- 1,917,471(+) ggaga(C/T)ggaga intron-variant
rs1057114 - 1,915,243(+) ACCAG(C/G)CCGGG missense, reference
rs1057124 -- 1,937,781(+) CCACA(C/T)ACCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIRPA Gene

Variant ID Type Subtype PubMed ID
dgv4516n71 CNV Gain 21882294
nsv3257 CNV Insertion 18451855
nsv511629 CNV Loss 21212237
esv25632 CNV Gain+Loss 19812545
esv1005896 CNV Gain 20482838
esv2722081 CNV Deletion 23290073
esv2722082 CNV Deletion 23290073
esv2722083 CNV Deletion 23290073
esv2722085 CNV Deletion 23290073

Variation tolerance for SIRPA Gene

Residual Variation Intolerance Score: 75.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.36; 99.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPA Gene

HapMap Linkage Disequilibrium report
SIRPA
Human Gene Mutation Database (HGMD)
SIRPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPA Gene

Disorders for SIRPA Gene

MalaCards: The human disease database

(10) MalaCards diseases for SIRPA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder neck obstruction
  • obstruction of bladder neck
thoracic outlet syndrome
  • tos - thoracic outlet syndrome
autoimmune hemolytic anemia
  • autoimmune hemolytic anemia nos
urethral stricture
acquired polycythemia
  • polycythemia, secondary
- elite association
Search SIRPA in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIRPA

Genetic Association Database (GAD)
SIRPA
Human Genome Epidemiology (HuGE) Navigator
SIRPA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPA
genes like me logo Genes that share disorders with SIRPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRPA Gene

Publications for SIRPA Gene

  1. Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. (PMID: 9070220) Yamao T. … Kasuga M. (Biochem. Biophys. Res. Commun. 1997) 2 23 67
  2. Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer. (PMID: 19795453) Tassidis H. … Wingren A.G. (Int. J. Cancer 2010) 23 67
  3. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. (PMID: 20139987) Capasso M. … Dyer M.J. (Nat. Immunol. 2010) 23 67
  4. Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells. (PMID: 20207740) Radhakrishnan Y. … Clemmons D.R. (J. Biol. Chem. 2010) 23 67
  5. Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. (PMID: 20299253) Tsai R.K. … Discher D.E. (Blood Cells Mol. Dis. 2010) 23 67

Products for SIRPA Gene

Sources for SIRPA Gene

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