Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SIRPA Gene

protein-coding   GIFtS: 62
GCID: GC20P001822

Signal-Regulatory Protein Alpha

(Previous names: protein tyrosine phosphatase, non-receptor type substrate...)
(Previous symbol: PTPNS1)
  See SIRPA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signal-Regulatory Protein Alpha1 2     Tyrosine Phosphatase SHP Substrate 12
PTPNS11 2 3     Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 12
SHPS12 3 5     Bit3
Inhibitory Receptor SHPS-12 3     MYD13
Macrophage Fusion Receptor2 3     SHPS-13
MyD-1 Antigen2 3     Sirp-alpha-13
BIT2 3     Sirp-alpha-23
MFR2 3     Sirp-alpha-33
SIRP2 3     Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs3
CD172 Antigen-Like Family Member A2 3     CD172a Antigen3
Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 11     p843
CD172A2     SHP Substrate 13
MYD-12     Signal-Regulatory Protein Alpha-13
P842     Signal-Regulatory Protein Alpha-23
Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs2     Signal-Regulatory Protein Alpha-33

External Ids:    HGNC: 96621   Entrez Gene: 1408852   Ensembl: ENSG000001980537   OMIM: 6024615   UniProtKB: P783243   

Export aliases for SIRPA gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SIRPA Gene:
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to
the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be
involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be
phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2
domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to
participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be
a ligand for this receptor protein. This gene and its product share very high similarity with several other
members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13.
Multiple alternatively spliced transcript variants have been determined for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SIRPA Gene:
SIRPA (signal-regulatory protein alpha) is a protein-coding gene. Diseases associated with SIRPA include vertebrobasilar insufficiency. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB2.

UniProtKB/Swiss-Prot: SHPS1_HUMAN, P78324
Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of
PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar
neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during
synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine
kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative
regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation
of immature dendritic cells and inhibits cytokine production by mature dendritic cells

Gene Wiki entry for SIRPA (Signal-regulatory protein alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRPA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRPA promoter sequence
   Search Chromatin IP Primers for SIRPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SIRPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRPA gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P001822:  view genomic region     (about GC identifiers)

Start:
1,874,813 bp from pter      End:
1,920,543 bp from pter
Size:
45,731 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SHPS1_HUMAN, P78324 (See protein sequence)
Recommended Name: Tyrosine-protein phosphatase non-receptor type substrate 1 precursor  
Size: 504 amino acids; 54967 Da
Subunit: Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds
GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a
stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B
4 PDB 3D structures from and Proteopedia for SIRPA:
2JJS (3D)        2JJT (3D)        2UV3 (3D)        2WNG (3D)    
Secondary accessions: A2A2E1 A8K411 B2R6C3 O00683 O43799 Q8N517 Q8TAL8 Q9H0Z2 Q9UDX2 Q9UIJ6
Q9Y4U9
Alternative splicing: 3 isoforms:  P78324-1   P78324-2   P78324-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRPA: NX_P78324

Explore proteomics data for SIRPA at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF.
    Dephosphorylated by PTPN111
  • Ubiquitination2 at Lys183
  • Glycosylation2 at Asn245, Asn270, Asn292, Asn319
  • Modification sites at PhosphoSitePlus

  • See SIRPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035111.1  NP_001035112.1  NP_542970.1  

    ENSEMBL proteins: 
     ENSP00000382941   ENSP00000348307   ENSP00000351621  
    Reactome Protein details: P78324

    SIRPA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SIRPA (SIRP alpha/CD172a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SIRPA
    OriGene Protein Over-expression Lysate for SIRPA
    OriGene MassSpec for SIRPA
    OriGene Custom Protein Services for SIRPA
    GenScript Custom Purified and Recombinant Proteins Services for SIRPA
    Novus Biologicals SIRPA Proteins
    Novus Biologicals SIRPA Lysates
    Sino Biological Recombinant Protein for SIRPA
    Sino Biological Cell Lysate for SIRPA
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SIRPA 

    SIRPA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRPA
    R&D Systems Antibodies for SIRPA (SIRP alpha/CD172a)
    OriGene Antibodies for SIRPA
    OriGene Custom Antibody Services for SIRPA
    Novus Biologicals SIRPA Antibodies
    Abcam antibodies for SIRPA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SIRPA
    LSBio Antibodies in human, mouse, rat for SIRPA

    SIRPA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SIRPA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SIRPA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SIRPA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SIRP: Signal-regulatory proteins
    CD: CD molecules
    C1SET: Immunoglobulin superfamily / C1-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P78324

    ProtoNet protein and cluster: P78324

    2 Blocks protein domains:
    IPB003597 Immunoglobulin C-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SHPS1_HUMAN, P78324
    Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIRPA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHPS1_HUMAN, P78324
    Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of
    PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar
    neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during
    synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine
    kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative
    regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation
    of immature dendritic cells and inhibits cytokine production by mature dendritic cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with SIRPA           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SIRPA:
     Increased Akt phosphorylation   Increased G2M DNA content  Increased number of mitotic ce  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sirpa):
     behavior/neurological  growth/size/body  hematopoietic system  immune system  liver/biliary system 
     nervous system 

    Find genes that share phenotypes with SIRPA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sirpatm1Nog for SIRPA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRPA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRPA

    miRNA
    Products:
        
    miRTarBase miRNAs that target SIRPA:
    hsa-mir-615-3p (MIRT040132), hsa-mir-106a-5p (MIRT035532), hsa-mir-20a-5p (MIRT035531), hsa-mir-17-5p (MIRT035530)

    Block miRNA regulation of human, mouse, rat SIRPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIRPA (see all 67):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-93 hsa-miR-3170 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSIRPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIRPA
    Predesigned siRNA for gene silencing in human, mouse, rat SIRPA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SIRPA

    Clone
    Products:
         
    OriGene clones in human, mouse for SIRPA (see all 21)
    OriGene ORF clones in mouse, rat for SIRPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SIRPA
    Sino Biological Human cDNA Clone for SIRPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SIRPA
    Browse ESI BIO Cell Lines and PureStem Progenitors for SIRPA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SHPS1_HUMAN, P78324: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS9062191
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SIRPA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SIRPA About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    Signal regulatory protein (SIRP) family interactions0.00
    2Hemostasis
    Hemostasis0.43
    3Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    4Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    5Jak/Stat Pathway
    Development Thrombopoetin signaling via JAK STAT pathway0.32


    Find genes that share SuperPaths with SIRPA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for SIRPA
        Immune response IL-2 activation and signaling pathway
    Development Thrombopoetin signaling via JAK-STAT pathway

    4 BioSystems Pathways for SIRPA
        IL-1 Signaling Pathway
    Cardiac Progenitor Differentiation
    BDNF signaling pathway
    Prolactin Signaling Pathway


    2 Reactome Pathways for SIRPA
        Signal regulatory protein (SIRP) family interactions
    Cell surface interactions at the vascular wall


    1 Kegg Pathway  (Kegg details for SIRPA):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIRPA
    Interactions:

        GeneGlobe Interaction Network for SIRPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRPA (P783243 ENSP000003483074) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD47Q087223, ENSP000003553614I2D: score=4 STRING: ENSP00000355361
    PTPN6P293503, ENSP000003915924I2D: score=4 STRING: ENSP00000391592
    NOL3O609363, ENSP000002686054I2D: score=3 STRING: ENSP00000268605
    TRIM2Q9C0403, ENSP000003396594I2D: score=3 STRING: ENSP00000339659
    PTPN11Q061243, ENSP000003409444I2D: score=2 STRING: ENSP00000340944
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9070220
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--

    Find genes that share ontologies with SIRPA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIRPA (SHPS1)

    10 Novoseek inferred chemical compound relationships for SIRPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 78.5 191 9582366 (5), 12483539 (4), 9344856 (4), 9535915 (4) (see all 99)
    phosphotyrosine 51.3 7 9261115 (1), 15888547 (1), 9148918 (1), 9927304 (1) (see all 5)
    phosphatidylinositol 35 5 15374953 (1), 20207740 (1), 10488096 (1), 11792697 (1) (see all 5)
    phenylalanine 7.28 3 18233962 (1), 9535915 (1)
    inositol 2.88 2 9422771 (1), 9236201 (1)
    nitric oxide 0 6 16055727 (4)
    lipid 0 3 17082646 (1), 11420038 (1), 15886119 (1)
    glucose 0 2 17652764 (1), 18292237 (1)
    calcium 0 1 15133509 (1)
    serine 0 1 15269224 (1)



    Find genes that share compounds with SIRPA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SIRPA gene (3 alternative transcripts): 
    NM_001040022.1  NM_001040023.1  NM_080792.2  

    Unigene Cluster for SIRPA:

    Signal-regulatory protein alpha
    Hs.581021  [show with all ESTs]
    Unigene Representative Sequence: NM_001040022
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400068(uc002wfq.3 uc010zps.2 uc002wft.3) ENST00000356025(uc002wfr.3)
    ENST00000358771(uc002wfs.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIRPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIRPA (see all 67):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-93 hsa-miR-3170 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSIRPA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SIRPA
    Predesigned siRNA for gene silencing in human, mouse, rat SIRPA
    Clone
    Products:
         
    OriGene clones in human, mouse for SIRPA (see all 21)
    OriGene ORF clones in mouse, rat for SIRPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SIRPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SIRPA
    OriGene qSTAR qPCR primer pairs in human, mouse for SIRPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIRPA
      QuantiTect SYBR Green Assays in human, mouse, rat SIRPA
      QuantiFast Probe-based Assays in human, mouse, rat SIRPA

    Additional mRNA sequence: 

    AB023430.1 AK290776.1 AK298243.1 AK312521.1 BC026692.1 BC033092.1 BC038510.2 BC075849.1 
    D86043.1 U06681.1 U06701.1 Y10375.1 Y11047.1 

    15 DOTS entries:

    DT.448770  DT.100694210  DT.100800960  DT.95349226  DT.100651082  DT.448769  DT.91743631  DT.100737950 
    DT.100759370  DT.95153159  DT.120813851  DT.95349256  DT.120813881  DT.120813916  DT.120813933 

    Selected AceView cDNA sequences (see all 265):

    CR602336 BC033092 BM989862 BU145206 AI289231 BU166488 AI912947 CD370391 
    BF914325 AA461201 AA417269 NM_080792 BQ883408 BU685881 AI282658 CD367926 
    AI934922 BQ427930 BM681705 BX476533 CD370502 AI263530 BQ712602 BQ614232 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SIRPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCAGGAG
    SIRPA Expression
    About this image


    SIRPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac mesoderm embryoid bodies
     
     NULL (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac mesoderm embryoid bodies
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
    SIRPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.581021

    UniProtKB/Swiss-Prot: SHPS1_HUMAN, P78324
    Tissue specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at
    lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney,
    skeletal muscle and pancreas

        Custom PCR Arrays for SIRPA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SIRPA
    OriGene qSTAR qPCR primer pairs in human, mouse for SIRPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIRPA
    QuantiTect SYBR Green Assays in human, mouse, rat SIRPA
    QuantiFast Probe-based Assays in human, mouse, rat SIRPA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SIRPA gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirpa1 , 5 signal-regulatory protein alpha1, 5 74.37(n)1
    66.14(a)1
      2 (63.19 cM)5
    192611  NM_001177646.11  NP_001171117.11 
     1295928355 
    chicken
    (Gallus gallus)
    Aves LOC7717341 tyrosine-protein phosphatase non-receptor type substrate more 57.79(n)
    46.54(a)
      771734  XM_001234975.3  XP_001234976.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    GL343515.1(139492-140536)


    ENSEMBL Gene Tree for SIRPA (if available)
    TreeFam Gene Tree for SIRPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SIRPA gene
    SIRPB22  SIRPD2  SIRPB12  SIRPG2  ENSG000002608612  
    3 SIMAP similar genes for SIRPA using alignment to 1 protein entry:     SHPS1_HUMAN:
    PTPNS1    SIRPB1    SIRPG

    Find genes that share paralogs with SIRPA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SIRPA
    PGOHUM00000246563


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SIRPA (see all 1242)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs755473051,2
    F--1821430(+) TTGCAC/TTTGGT 1 -- us2k13Minor allele frequency- T:0.06CSA WA 122
    rs1127580741,2
    C--1822435(+) TCGGGC/-CCCTC 1 -- ut511Minor allele frequency- -:0.50CSA 2
    rs1448159951,2
    C--1872848(+) CTCCA-/GGGGGG 1 -- us2k10--------
    rs769911891,2
    C,F--1872977(+) GTGTGT/CATGTG 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs27495561,2
    C,F,A,H--1873160(+) AAGAGT/CTGGAG 1 -- us2k114Minor allele frequency- C:0.45NA EA WA CSA 733
    rs1123209371,2
    C,F--1873174(+) TTCCCT/CGCACC 1 -- us2k12Minor allele frequency- C:0.06NA 122
    rs1482273021,2
    C--1873244(+) TCCTCC/TCTCTC 1 -- us2k10--------
    rs1876123601,2
    --1873263(+) CCTCCG/TCTTGC 1 -- us2k10--------
    rs797878581,2
    C--1873274(+) AGACTG/AGCCTT 1 -- us2k14Minor allele frequency- A:0.07CSA WA NA EA 359
    rs1417133071,2
    --1873344(+) CTGCAA/GAATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIRPA (1874813 - 1920543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SIRPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722085CNV Deletion23290073
    esv2722082CNV Deletion23290073
    esv2722083CNV Deletion23290073
    esv2722081CNV Deletion23290073
    nsv3257CNV Insertion18451855
    nsv511629CNV Loss21212237
    dgv4516n71CNV Gain21882294
    esv1005896CNV Gain20482838
    esv25632CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRPA
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602461    OMIM disorders: --

    1 disease for SIRPA:    
    About MalaCards
    vertebrobasilar insufficiency

    2 diseases from the University of Copenhagen DISEASES database for SIRPA:
    Autoimmune hemolytic anemia     Vertebrobasilar insufficiency

    Find genes that share disorders with SIRPA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SIRPA gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperglycemia 23.8 1 20207740 (1)
    autoimmune diseases 5.77 1 15359629 (1)
    leukemia 1.5 3 9507023 (1), 15784688 (1)
    necrosis 0 6 12446684 (1), 18233962 (1), 16055727 (1), 18820737 (1) (see all 5)
    inflammation 0 2 14531999 (1), 18441283 (1)
    hepatocellular carcinoma 0 4 10921027 (2), 17548251 (2)
    glioblastoma 0 6 10962556 (3), 15374953 (1)
    tumors 0 15 17632076 (2), 10921027 (1), 12446684 (1), 15349900 (1) (see all 11)
    pancreatic cancer 0 1 9927304 (1)
    melanoma 0 4 12773380 (2), 14739297 (1)

    Genetic Association Database (GAD): SIRPA
    Human Genome Epidemiology (HuGE) Navigator: SIRPA (1 document)

    Export disorders for SIRPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SIRPA gene, integrated from 10 sources (see all 237):
    (articles sorted by number of sources associating them with SIRPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. (PubMed id 9070220)1, 2, 3, 9 Yamao T.... Kasuga M. (Biochem. Biophys. Res. Commun. 1997)
    2. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PubMed id 9062191)1, 2, 3 Kharitonenkov A....Ullrich A. (Nature 1997)
    3. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. (PubMed id 10842184)1, 2, 9 Stofega M.R.... Carter-Su C. (J. Biol. Chem. 2000)
    4. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. (PubMed id 10469599)1, 2, 9 Timms J.F.... Neel B.G. (Curr. Biol. 1999)
    5. Gene structure of mouse BIT/SHPS-1. (PubMed id 10585853)1, 2, 9 Sano S.... Kubota M. (Biochem. J. 1999)
    6. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PubMed id 21223598)1, 4 Wineinger N.E....Tiwari H.K. (BMC Med Genomics 2011)
    7. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    9. A nomenclature for signal regulatory protein family members. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (J. Immunol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 140885 HGNC: 9662 AceView: PTPNS1 Ensembl:ENSG00000198053 euGenes: HUgn140885
    ECgene: SIRPA Kegg: 140885 H-InvDB: SIRPA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SIRPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SIRPA gene:
    Search GeneIP for patents involving SIRPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRPA
     
     EMD Millipore genomic analysis products

      
     Antibodies for SIRPA (SIRP alpha/CD172a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SIRPA (SIRP alpha/CD172a)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SIRPA   OriGene RNAi products in human, mouse, rat for SIRPA  
     OriGene qPCR primer pairs and template standards for SIRPA   OriGene Protein Over-expression Lysate for SIRPA  
     OriGene MassSpec something-or-other for SIRPA   OriGene clones in human, mouse for SIRPA  
     OriGene qSTAR qPCR primer pairs in human, mouse for SIRPA   OriGene Purified Protein for SIRPA  
     OriGene ORF clones in mouse, rat for SIRPA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SIRPA   OriGene Custom Protein Services for SIRPA  

     
     
     Block miRNA regulation of human, mouse, rat SIRPA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SIRPA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRPA Predesigned siRNA for gene silencing in human, mouse, rat SIRPA
     QuantiFast Probe-based Assays in human, mouse, rat SIRPA QuantiTect SYBR Green Assays in human, mouse, rat SIRPA
     Custom PCR Arrays for SIRPA Search Chromatin IP Primers for SIRPA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIRPA  GeneGlobe Interaction Network for SIRPA
     Regulatory tfbs in SIRPA promoter
     GenScript Custom Purified and Recombinant Proteins Services for SIRPA GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SIRPA
     GenScript Custom Assay Services for SIRPA GenScript Custom overexpressing Cell Line Services for SIRPA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SIRPA (SHPS1)
     Proteins for SIRPA
     Cell Lysates for SIRPA
     cDNA Clones for SIRPA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SIRPA antibodies
     SIRPA proteins
     SIRPA lysates
     Antibodies for SIRPA
     See all of Abcam's Antibodies, Kits and Proteins for SIRPA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SIRPA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPA
     SwitchGear 3'UTR luciferase reporter plasmids for SIRPA
     SwitchGear Promoter luciferase reporter plasmids for SIRPA
     ThermoFisher Antibody for SIRPA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRPA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRPA
     LSBio Antibodies in human, mouse, rat for SIRPA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SIRPA
      Search eBioscience for proteins for SIRPA
      Search eBioscience for elisas for SIRPA
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SIRPA gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4