SIPA1L3 Gene
protein-coding GIFtS: 49
GCID: GC19P038397
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|
signal-induced proliferation-associated 1 like 3
| |
Aliases
for SIPA1L3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal-Induced Proliferation-Associated 1 Like 31 2 | | SPA-1-Like Protein 32 3 | | KIAA05451 3 | | Signal-Induced Proliferation-Associated 1-Like Protein 32 | | SPAL32 3 | | SPA-1-Like 32 | | SIPA1-Like Protein 32 3 | | |
Export aliases for SIPA1L3 gene to outside databasesPrevious GC identifers: GC19P043090 GC19P043264 GC19P034846 |
Summaries
for SIPA1L3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SIPA1L3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SIPA1L3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIPA1L3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIPA1L3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.13 HGNC cytogenetic band: 19q13.13SIPA1L3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P038397: view genomic region
(about GC identifiers)
Start:
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38,397,861 bp from pter |
End:
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38,699,012 bp from pter |
Size:
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301,152 bases |
Orientation:
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plus strand |
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Proteins
for SIPA1L3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SI1L3_HUMAN, O60292 (See
protein sequence)Recommended Name: Signal-induced proliferation-associated 1-like protein 3 Size: 1781 amino acids; 194610 Da
Secondary accessions: Q2TV87Explore the universe of human proteins at neXtProt for SIPA1L3: NX_O60292
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60292
SIPA1L3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055888.1
ENSEMBL proteins: ENSP00000222345
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
SIPA1L3 for ontologies About GeneDecksing
SIPA1L3 Antibody Products:
Assay Products for SIPA1L3: |
Protein
Domains /
Families
for SIPA1L3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIPA1L3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60292ProtoNet protein and cluster: O60292 1 Blocks protein family: IPB000331 Rap/ran-GAP
UniProtKB/Swiss-Prot: SI1L3_HUMAN, O60292Similarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 Rap-GAP domain |
Function
for SIPA1L3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIPA1L3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIPA1L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1L3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- |
SIPA1L3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SIPA1L3:
|
Pathways & Interactions
for SIPA1L3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIPA1L3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for SIPA1L3 (O602922, 3 ENSP000002223454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051056 | regulation of small GTPase mediated signal transduction |
IEA | -- |
SIPA1L3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIPA1L3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIPA1L3
Search CenterWatch for drugs/clinical trials and news about SIPA1L3 / SI1L3
|
Transcripts
for SIPA1L3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIPA1L3 gene: NM_015073.1 Unigene Cluster for SIPA1L3: Signal-induced proliferation-associated 1 like 3 Hs.655502 [show with all ESTs]Unigene Representative Sequence: NM_0150732 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000222345(uc002ohk.3) ENST00000476317
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIPA1L3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIPA1L3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIPA1L3 (NM_015073) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIPA1L3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIPA1L3 |
Additional cDNA sequence: AB011117.2 AY168880.1 BC036863.1 BC150620.1 5 DOTS entries: DT.211352 DT.86846698 DT.92420546 DT.97777491 DT.121433451 24/146 AceView cDNA sequences (see all 146): BX119674 BC036863 BF514240 CK825844 CK822912 CK822913 AL045302 BF512102 BQ086199 BU167319 AA938672 BF590866 AI436557 BQ102303 AI873534 AL040865 AI701372 R13584 AA768800 CB141350 BI770004 BF001536 AI218347 CD674977
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIPA1L3
|
Expression
for SIPA1L3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIPA1L3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGGAGG
About this image
See SIPA1L3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIPA1L3
SOURCE GeneReport for Unigene cluster: Hs.655502
SABiosciences Custom PCR Arrays for SIPA1L3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIPA1L3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIPA1L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIPA1L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIPA1L3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1L3 |
Orthologs
for SIPA1L3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SIPA1L3 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for SIPA1L3 (if available)
TreeFam Gene Tree for SIPA1L3 (if available) |
Paralogs
for SIPA1L3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIPA1L3 gene
- SIPA1L12 SIPA12 RAP1GAP2 SIPA1L22 GARNL32 RAP1GAP22
3 SIMAP similar genes for SIPA1L3 using alignment to 7 protein entries: SI1L3_HUMAN (see all proteins):SIPA1L1 SIPA1L2 SIPA1
SIPA1L3 for paralogs About GeneDecksing
|
Genomic Variants
for SIPA1L3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIPA1L3 (38397861 - 38647861 bp, first 250kb of SIPA1L3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SIPA1L3
3 CNVs: 5953 102837 5099 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIPA1L3 |
|
Disorders
/ Diseases
for SIPA1L3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SIPA1L3 for disorders About MalaCards
SIPA1L3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SIPA1L3 (1 document)
Export disorders for SIPA1L3 gene to outside databases
|
Publications
for SIPA1L3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIPA1L3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SIPA1L3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465)1 Benzinger A.... Hermeking H. (2005)
|
External Searches for SIPA1L3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIPA1L3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIPA1L3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SIPA1L3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIPA1L3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SIPA1L3 gene:
Search GeneIP for patents involving SIPA1L3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIPA1L3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for SIPA1L3 | | OriGene Custom Protein Services for SIPA1L3 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIPA1L3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIPA1L3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIPA1L3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIPA1L3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIPA1L3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIPA1L3 |
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 | | | SIPA1L3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1L3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIPA1L3 |
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