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Aliases for SIPA1L3 Gene

Aliases for SIPA1L3 Gene

  • Signal-Induced Proliferation-Associated 1 Like 3 2 3
  • SIPA1-Like Protein 3 3 4
  • SPA-1-Like Protein 3 3 4
  • SPAL3 3 4
  • Signal-Induced Proliferation-Associated 1-Like Protein 3 3
  • SPA-1-Like 3 3
  • KIAA0545 4

External Ids for SIPA1L3 Gene

Previous GeneCards Identifiers for SIPA1L3 Gene

  • GC19P043090
  • GC19P043264
  • GC19P038397
  • GC19P034846

Summaries for SIPA1L3 Gene

GeneCards Summary for SIPA1L3 Gene

SIPA1L3 (Signal-Induced Proliferation-Associated 1 Like 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SIPA1L2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L3 Gene

Genomics for SIPA1L3 Gene

Genomic Location for SIPA1L3 Gene

37,906,889 bp from pter
38,208,372 bp from pter
301,484 bases
Plus strand

Genomic View for SIPA1L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIPA1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L3 Gene

No data available for Regulatory Elements for SIPA1L3 Gene

Proteins for SIPA1L3 Gene

  • Protein details for SIPA1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2TV87

    Protein attributes for SIPA1L3 Gene

    1781 amino acids
    Molecular mass:
    194610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIPA1L3 Gene

Proteomics data for SIPA1L3 Gene at MOPED

Post-translational modifications for SIPA1L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIPA1L3 Gene

No data available for DME Specific Peptides for SIPA1L3 Gene

Domains for SIPA1L3 Gene

Protein Domains for SIPA1L3 Gene


Suggested Antigen Peptide Sequences for SIPA1L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O60292
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with SIPA1L3: view

No data available for Gene Families for SIPA1L3 Gene

Function for SIPA1L3 Gene

Gene Ontology (GO) - Molecular Function for SIPA1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SIPA1L3: view

Phenotypes for SIPA1L3 Gene

GenomeRNAi human phenotypes for SIPA1L3:
genes like me logo Genes that share phenotypes with SIPA1L3: view

Animal Model Products

CRISPR Products

miRNA for SIPA1L3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIPA1L3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIPA1L3 Gene

Localization for SIPA1L3 Gene

Subcellular locations from

Jensen Localization Image for SIPA1L3 Gene COMPARTMENTS Subcellular localization image for SIPA1L3 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SIPA1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
genes like me logo Genes that share ontologies with SIPA1L3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SIPA1L3 Gene

Pathways for SIPA1L3 Gene

SuperPathways for SIPA1L3 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with SIPA1L3: view

Pathways by source for SIPA1L3 Gene

1 KEGG pathway for SIPA1L3 Gene

Interacting Proteins for SIPA1L3 Gene

Gene Ontology (GO) - Biological Process for SIPA1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction --
genes like me logo Genes that share ontologies with SIPA1L3: view

Transcripts for SIPA1L3 Gene

Unigene Clusters for SIPA1L3 Gene

Signal-induced proliferation-associated 1 like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIPA1L3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22
SP1: - - -

Relevant External Links for SIPA1L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1L3 Gene

mRNA expression in normal human tissues for SIPA1L3 Gene

Protein differential expression in normal tissues for SIPA1L3 Gene

This gene is overexpressed in Liver, secretome (30.2), Islet of Langerhans (8.2), Retina (8.1), Pancreas (6.7), and Monocytes (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1L3 Gene

SOURCE GeneReport for Unigene cluster for SIPA1L3 Gene Hs.655502

genes like me logo Genes that share expressions with SIPA1L3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for SIPA1L3 Gene

Orthologs for SIPA1L3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIPA1L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIPA1L3 35
  • 89.01 (n)
  • 92.16 (a)
SIPA1L3 36
  • 79 (a)
(Canis familiaris)
Mammalia SIPA1L3 35
  • 89.58 (n)
  • 92.84 (a)
SIPA1L3 36
  • 92 (a)
(Mus musculus)
Mammalia Sipa1l3 35
  • 86.41 (n)
  • 91.54 (a)
Sipa1l3 16
Sipa1l3 36
  • 91 (a)
(Pan troglodytes)
Mammalia SIPA1L3 35
  • 99.12 (n)
  • 99.32 (a)
SIPA1L3 36
  • 99 (a)
(Monodelphis domestica)
Mammalia SIPA1L3 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SIPA1L3 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SIPA1L3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l3 35
  • 64.69 (n)
  • 68.12 (a)
Str.10258 35
(Danio rerio)
Actinopterygii si:dkey-149j18.1 35
  • 61.41 (n)
  • 62 (a)
CABZ01030262.1 36
  • 34 (a)
Species with no ortholog for SIPA1L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L3 Gene

Gene Tree for SIPA1L3 (if available)
Gene Tree for SIPA1L3 (if available)

Paralogs for SIPA1L3 Gene

Paralogs for SIPA1L3 Gene

genes like me logo Genes that share paralogs with SIPA1L3: view

Variants for SIPA1L3 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs183586 -- 37,924,678(-) ttttt(G/T)gagat intron-variant
rs332838 -- 38,186,343(+) agtgt(C/T)gctct intron-variant
rs332839 -- 38,185,402(+) CTCCT(C/T)AACAA intron-variant
rs332840 -- 38,184,458(+) CAGGC(A/G)TGAGC intron-variant
rs332841 -- 38,184,051(+) TCAGT(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L3 Gene

Variant ID Type Subtype PubMed ID
nsv833820 CNV Loss 17160897
esv2610413 CNV Deletion 19546169
nsv911656 CNV Gain 21882294
esv2658332 CNV Deletion 23128226
esv1080341 CNV Insertion 17803354
nsv138463 CNV Loss 16902084
nsv833821 CNV Loss 17160897
nsv911657 CNV Loss 21882294
esv2670217 CNV Deletion 23128226
esv2718531 CNV Deletion 23290073

Relevant External Links for SIPA1L3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1L3 Gene

Disorders for SIPA1L3 Gene

Relevant External Links for SIPA1L3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SIPA1L3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SIPA1L3 Gene

Publications for SIPA1L3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3

Products for SIPA1L3 Gene

Sources for SIPA1L3 Gene

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