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Aliases for SIPA1L2 Gene

Aliases for SIPA1L2 Gene

  • Signal Induced Proliferation Associated 1 Like 2 2 3
  • Signal-Induced Proliferation-Associated 1 Like 2 2 3 5
  • SIPA1-Like Protein 2 3 4
  • SPA-1-Like 2 3
  • KIAA1389 4
  • SPAL2 3

External Ids for SIPA1L2 Gene

Previous GeneCards Identifiers for SIPA1L2 Gene

  • GC01M229617
  • GC01M228840
  • GC01M230600
  • GC01M232533
  • GC01M203022

Summaries for SIPA1L2 Gene

Entrez Gene Summary for SIPA1L2 Gene

  • This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]

GeneCards Summary for SIPA1L2 Gene

SIPA1L2 (Signal Induced Proliferation Associated 1 Like 2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP.

Gene Wiki entry for SIPA1L2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L2 Gene

Genomics for SIPA1L2 Gene

Regulatory Elements for SIPA1L2 Gene

Enhancers for SIPA1L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIPA1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIPA1L2 Gene

232,397,965 bp from pter
232,630,696 bp from pter
232,732 bases
Minus strand

Genomic View for SIPA1L2 Gene

Genes around SIPA1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L2 Gene

Proteins for SIPA1L2 Gene

  • Protein details for SIPA1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2TV88
    • Q5VXR7
    • Q5VXR8
    • Q641Q4
    • Q8NA38
    • Q96DZ3
    • Q9H9F6

    Protein attributes for SIPA1L2 Gene

    1722 amino acids
    Molecular mass:
    190438 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92627.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14273.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIPA1L2 Gene


neXtProt entry for SIPA1L2 Gene

Proteomics data for SIPA1L2 Gene at MOPED

Post-translational modifications for SIPA1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIPA1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SIPA1L2 Gene

Domains & Families for SIPA1L2 Gene

Gene Families for SIPA1L2 Gene

Protein Domains for SIPA1L2 Gene


Suggested Antigen Peptide Sequences for SIPA1L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with SIPA1L2: view

Function for SIPA1L2 Gene

Gene Ontology (GO) - Molecular Function for SIPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with SIPA1L2: view

Phenotypes for SIPA1L2 Gene

genes like me logo Genes that share phenotypes with SIPA1L2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIPA1L2 Gene

Localization for SIPA1L2 Gene

Subcellular locations from

Jensen Localization Image for SIPA1L2 Gene COMPARTMENTS Subcellular localization image for SIPA1L2 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SIPA1L2 Gene

Pathways & Interactions for SIPA1L2 Gene

SuperPathways for SIPA1L2 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with SIPA1L2: view

Pathways by source for SIPA1L2 Gene

1 KEGG pathway for SIPA1L2 Gene

Gene Ontology (GO) - Biological Process for SIPA1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with SIPA1L2: view

No data available for SIGNOR curated interactions for SIPA1L2 Gene

Drugs & Compounds for SIPA1L2 Gene

No Compound Related Data Available

Transcripts for SIPA1L2 Gene

Unigene Clusters for SIPA1L2 Gene

Signal-induced proliferation-associated 1 like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: - - -
SP3: -
SP4: -

ExUns: 22a · 22b · 22c

Relevant External Links for SIPA1L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1L2 Gene

mRNA expression in normal human tissues for SIPA1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIPA1L2 Gene

This gene is overexpressed in Fetal Brain (24.9), Adipocyte (19.9), Placenta (7.1), and Retina (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1L2 Gene

SOURCE GeneReport for Unigene cluster for SIPA1L2 Gene Hs.745009

genes like me logo Genes that share expression patterns with SIPA1L2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SIPA1L2 Gene

Orthologs for SIPA1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIPA1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIPA1L2 35
  • 86.2 (n)
  • 93.42 (a)
SIPA1L2 36
  • 93 (a)
(Canis familiaris)
Mammalia SIPA1L2 35
  • 88.68 (n)
  • 95.12 (a)
SIPA1L2 36
  • 95 (a)
(Mus musculus)
Mammalia Sipa1l2 35
  • 83.2 (n)
  • 91.51 (a)
Sipa1l2 16
Sipa1l2 36
  • 91 (a)
(Pan troglodytes)
Mammalia SIPA1L2 35
  • 99.48 (n)
  • 99.59 (a)
SIPA1L2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sipa1l2 35
  • 82.88 (n)
  • 91.22 (a)
(Monodelphis domestica)
Mammalia SIPA1L2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SIPA1L2 36
  • 63 (a)
(Gallus gallus)
Aves SIPA1L2 35
  • 77.93 (n)
  • 86.89 (a)
SIPA1L2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SIPA1L2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l2 35
  • 68.55 (n)
  • 70.29 (a)
Str.20345 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19940 35
(Danio rerio)
Actinopterygii im:7137555 35
  • 64.75 (n)
  • 65.19 (a)
SIPA1L2 (1 of 2) 36
  • 60 (a)
SIPA1L2 (2 of 2) 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008488 35
  • 55.91 (n)
  • 57.32 (a)
Species with no ortholog for SIPA1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L2 Gene

Gene Tree for SIPA1L2 (if available)
Gene Tree for SIPA1L2 (if available)

Paralogs for SIPA1L2 Gene

(3) SIMAP similar genes for SIPA1L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIPA1L2: view

Variants for SIPA1L2 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16857502 - 232,515,195(+) AGAAG(C/T)AGTGG reference, missense
rs2275307 - 232,439,175(-) CGTCC(A/G)CCATC reference, missense
rs1547742 - 232,432,295(-) GAAAT(C/T)GGAGG reference, missense
rs2275303 - 232,403,473(+) TTTGC(C/T)ACTGC reference, missense
rs3210731 - 232,428,551(-) GTGAG(A/T)TGGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L2 Gene

Variant ID Type Subtype PubMed ID
nsv873302 CNV Gain 21882294
esv2724961 CNV Deletion 23290073
esv2724972 CNV Deletion 23290073
nsv820068 CNV Loss 19587683
dgv546n71 CNV Loss 21882294
esv269082 CNV Insertion 20981092
esv273096 CNV Insertion 20981092
esv994086 CNV Insertion 20482838
esv1056324 CNV Insertion 17803354
esv2750829 CNV Gain 17911159
esv2666130 CNV Deletion 23128226
esv2724983 CNV Deletion 23290073

Variation tolerance for SIPA1L2 Gene

Residual Variation Intolerance Score: 2.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.50; 88.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIPA1L2 Gene

Disorders for SIPA1L2 Gene

Relevant External Links for SIPA1L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIPA1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1L2 Gene

Publications for SIPA1L2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3

Products for SIPA1L2 Gene

Sources for SIPA1L2 Gene