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Aliases for SIPA1L1 Gene

Aliases for SIPA1L1 Gene

  • Signal Induced Proliferation Associated 1 Like 1 2 3
  • Signal-Induced Proliferation-Associated 1 Like 1 2 3 5
  • High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 3 4
  • SIPA1-Like Protein 1 3 4
  • E6TP1 3 4
  • E6-Targeted Protein 1 4
  • KIAA0440 4

External Ids for SIPA1L1 Gene

Previous GeneCards Identifiers for SIPA1L1 Gene

  • GC14P069987
  • GC14P069988
  • GC14P071065
  • GC14P071996
  • GC14P052162
  • GC14P071787

Summaries for SIPA1L1 Gene

GeneCards Summary for SIPA1L1 Gene

SIPA1L1 (Signal Induced Proliferation Associated 1 Like 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include GTPase activator activity and ephrin receptor binding. An important paralog of this gene is RAP1GAP.

UniProtKB/Swiss-Prot for SIPA1L1 Gene

  • Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Gene Wiki entry for SIPA1L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L1 Gene

Genomics for SIPA1L1 Gene

Regulatory Elements for SIPA1L1 Gene

Enhancers for SIPA1L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIPA1L1 on UCSC Golden Path with GeneCards custom track

Promoters for SIPA1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIPA1L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIPA1L1 Gene

Chromosome:
14
Start:
71,320,449 bp from pter
End:
71,741,229 bp from pter
Size:
420,781 bases
Orientation:
Plus strand

Genomic View for SIPA1L1 Gene

Genes around SIPA1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L1 Gene

Proteins for SIPA1L1 Gene

  • Protein details for SIPA1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43166-SI1L1_HUMAN
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 1
    Protein Accession:
    O43166
    Secondary Accessions:
    • J3KP19
    • O95321
    • Q9UDU4
    • Q9UNU4

    Protein attributes for SIPA1L1 Gene

    Size:
    1804 amino acids
    Molecular mass:
    200029 Da
    Quaternary structure:
    • Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
    SequenceCaution:
    • Sequence=BAA23712.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIPA1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIPA1L1 Gene

Proteomics data for SIPA1L1 Gene at MOPED

Post-translational modifications for SIPA1L1 Gene

  • Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).
  • Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SIPA1L1 Gene

Domains & Families for SIPA1L1 Gene

Gene Families for SIPA1L1 Gene

Protein Domains for SIPA1L1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SIPA1L1 Gene

Graphical View of Domain Structure for InterPro Entry

O43166

UniProtKB/Swiss-Prot:

SI1L1_HUMAN :
  • Contains 1 PDZ (DHR) domain.
Domain:
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with SIPA1L1: view

Function for SIPA1L1 Gene

Molecular function for SIPA1L1 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Phenotypes for SIPA1L1 Gene

genes like me logo Genes that share phenotypes with SIPA1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIPA1L1 Gene

Localization for SIPA1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIPA1L1 Gene COMPARTMENTS Subcellular localization image for SIPA1L1 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIPA1L1: view

Pathways & Interactions for SIPA1L1 Gene

SuperPathways for SIPA1L1 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with SIPA1L1: view

Pathways by source for SIPA1L1 Gene

1 KEGG pathway for SIPA1L1 Gene

Gene Ontology (GO) - Biological Process for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048167 regulation of synaptic plasticity ISS --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
GO:0090630 activation of GTPase activity ISS --
genes like me logo Genes that share ontologies with SIPA1L1: view

No data available for SIGNOR curated interactions for SIPA1L1 Gene

Drugs & Compounds for SIPA1L1 Gene

No Compound Related Data Available

Transcripts for SIPA1L1 Gene

Unigene Clusters for SIPA1L1 Gene

Signal-induced proliferation-associated 1 like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:

ExUns: 20b ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SIPA1L1 Gene

GeneLoc Exon Structure for
SIPA1L1
ECgene alternative splicing isoforms for
SIPA1L1

Expression for SIPA1L1 Gene

mRNA expression in normal human tissues for SIPA1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIPA1L1 Gene

This gene is overexpressed in Kidney (21.5), Bone marrow mesenchymal stem cell (9.8), Peripheral blood mononuclear cells (6.6), and Spleen (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1L1 Gene



SOURCE GeneReport for Unigene cluster for SIPA1L1 Gene Hs.654657

mRNA Expression by UniProt/SwissProt for SIPA1L1 Gene

O43166-SI1L1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SIPA1L1: view

Protein tissue co-expression partners for SIPA1L1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SIPA1L1 Gene

Orthologs for SIPA1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIPA1L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIPA1L1 35
  • 90.3 (n)
  • 96.9 (a)
SIPA1L1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIPA1L1 35
  • 90.26 (n)
  • 97.12 (a)
SIPA1L1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sipa1l1 35
  • 88.57 (n)
  • 95.85 (a)
Sipa1l1 16
Sipa1l1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIPA1L1 35
  • 99.58 (n)
  • 99.83 (a)
SIPA1L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sipa1l1 35
  • 88.54 (n)
  • 95.34 (a)
oppossum
(Monodelphis domestica)
Mammalia SIPA1L1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIPA1L1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIPA1L1 35
  • 81.2 (n)
  • 90.43 (a)
SIPA1L1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIPA1L1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l1 35
  • 73.18 (n)
  • 79.15 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
sipa1l1 35
  • 63.06 (n)
  • 65.21 (a)
sipa1l1 36
  • 59 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8585 35
Species with no ortholog for SIPA1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L1 Gene

ENSEMBL:
Gene Tree for SIPA1L1 (if available)
TreeFam:
Gene Tree for SIPA1L1 (if available)

Paralogs for SIPA1L1 Gene

(5) SIMAP similar genes for SIPA1L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SIPA1L1: view

Variants for SIPA1L1 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035549 A breast cancer sample
rs12884638 - 71,588,038(+) TAGGA(A/C)CCCCC reference, missense
rs36528 -- 71,474,418(-) AGGAC(G/T)GTATC intron-variant
rs36529 -- 71,473,175(-) AGTAA(A/T)GTGTA intron-variant
rs36530 -- 71,469,766(-) ACAAA(C/T)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L1 Gene

Variant ID Type Subtype PubMed ID
nsv85474 CNV Loss 16902084
esv32876 CNV Gain 17666407
nsv84708 CNV Loss 16902084

Variation tolerance for SIPA1L1 Gene

Residual Variation Intolerance Score: 0.771% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIPA1L1 Gene

HapMap Linkage Disequilibrium report
SIPA1L1
Human Gene Mutation Database (HGMD)
SIPA1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Disorders for SIPA1L1 Gene

Relevant External Links for SIPA1L1

Genetic Association Database (GAD)
SIPA1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIPA1L1

No disorders were found for SIPA1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1L1 Gene

Publications for SIPA1L1 Gene

  1. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. (PMID: 9858596) Gao Q. … Band V. (Mol. Cell. Biol. 1999) 2 3 4 23 67
  2. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. (PMID: 16999984) Lee C. … Laimins L.A. (Virology 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for SIPA1L1 Gene

Sources for SIPA1L1 Gene

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