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Aliases for SIPA1L1 Gene

Aliases for SIPA1L1 Gene

  • Signal-Induced Proliferation-Associated 1 Like 1 2 3
  • High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 3 4
  • SIPA1-Like Protein 1 3 4
  • E6TP1 3 4
  • Signal-Induced Proliferation-Associated 1-Like Protein 1 3
  • E6-Targeted Protein 1 4
  • KIAA0440 4

External Ids for SIPA1L1 Gene

Previous GeneCards Identifiers for SIPA1L1 Gene

  • GC14P069987
  • GC14P069988
  • GC14P071065
  • GC14P071996
  • GC14P052162
  • GC14P071787

Summaries for SIPA1L1 Gene

GeneCards Summary for SIPA1L1 Gene

SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1) is a Protein Coding gene. Diseases associated with SIPA1L1 include papilloma. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include GTPase activator activity and ephrin receptor binding. An important paralog of this gene is SIPA1L2.

UniProtKB/Swiss-Prot for SIPA1L1 Gene

  • Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Gene Wiki entry for SIPA1L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L1 Gene

Genomics for SIPA1L1 Gene

Regulatory Elements for SIPA1L1 Gene

Genomic Location for SIPA1L1 Gene

71,320,449 bp from pter
71,741,229 bp from pter
420,781 bases
Plus strand

Genomic View for SIPA1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIPA1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L1 Gene

Proteins for SIPA1L1 Gene

  • Protein details for SIPA1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 1
    Protein Accession:
    Secondary Accessions:
    • J3KP19
    • O95321
    • Q9UDU4
    • Q9UNU4

    Protein attributes for SIPA1L1 Gene

    1804 amino acids
    Molecular mass:
    200029 Da
    Quaternary structure:
    • Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
    • Sequence=BAA23712.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIPA1L1 Gene


neXtProt entry for SIPA1L1 Gene

Proteomics data for SIPA1L1 Gene at MOPED

Post-translational modifications for SIPA1L1 Gene

  • Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).
  • Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIPA1L1 Gene

Domains for SIPA1L1 Gene

Protein Domains for SIPA1L1 Gene


Suggested Antigen Peptide Sequences for SIPA1L1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O43166
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with SIPA1L1: view

No data available for Gene Families for SIPA1L1 Gene

Function for SIPA1L1 Gene

Molecular function for SIPA1L1 Gene

UniProtKB/Swiss-Prot Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0046875 ephrin receptor binding IEA --
genes like me logo Genes that share ontologies with SIPA1L1: view

Animal Model Products

CRISPR Products

miRNA for SIPA1L1 Gene

miRTarBase miRNAs that target SIPA1L1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIPA1L1 Gene

Localization for SIPA1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SIPA1L1 Gene COMPARTMENTS Subcellular localization image for SIPA1L1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SIPA1L1: view

Pathways for SIPA1L1 Gene

SuperPathways for SIPA1L1 Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with SIPA1L1: view

Pathways by source for SIPA1L1 Gene

1 KEGG pathway for SIPA1L1 Gene

Gene Ontology (GO) - Biological Process for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031532 actin cytoskeleton reorganization ISS --
GO:0043087 regulation of GTPase activity ISS --
GO:0043547 positive regulation of GTPase activity --
GO:0048013 ephrin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with SIPA1L1: view

Transcripts for SIPA1L1 Gene

Unigene Clusters for SIPA1L1 Gene

Signal-induced proliferation-associated 1 like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIPA1L1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SIPA1L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP2: -
SP5: - -
SP10: - -

ExUns: 20b ^ 21 ^ 22

Relevant External Links for SIPA1L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1L1 Gene

mRNA expression in normal human tissues for SIPA1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1L1 Gene

SOURCE GeneReport for Unigene cluster for SIPA1L1 Gene Hs.654657

mRNA Expression by UniProt/SwissProt for SIPA1L1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SIPA1L1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SIPA1L1 Gene

Orthologs for SIPA1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIPA1L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIPA1L1 35
  • 99.58 (n)
  • 99.83 (a)
SIPA1L1 36
  • 100 (a)
(Bos Taurus)
Mammalia SIPA1L1 35
  • 90.3 (n)
  • 96.9 (a)
SIPA1L1 36
  • 97 (a)
(Canis familiaris)
Mammalia SIPA1L1 35
  • 90.26 (n)
  • 97.12 (a)
SIPA1L1 36
  • 97 (a)
(Mus musculus)
Mammalia Sipa1l1 35
  • 88.57 (n)
  • 95.85 (a)
Sipa1l1 16
Sipa1l1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia SIPA1L1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SIPA1L1 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Sipa1l1 35
  • 88.54 (n)
  • 95.34 (a)
(Gallus gallus)
Aves SIPA1L1 35
  • 81.2 (n)
  • 90.43 (a)
SIPA1L1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia SIPA1L1 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l1 35
  • 73.18 (n)
  • 79.15 (a)
(Danio rerio)
Actinopterygii -- 35
sipa1l1 35
  • 63.06 (n)
  • 65.21 (a)
sipa1l1 36
  • 59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8585 35
Species with no ortholog for SIPA1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L1 Gene

Gene Tree for SIPA1L1 (if available)
Gene Tree for SIPA1L1 (if available)

Paralogs for SIPA1L1 Gene

Paralogs for SIPA1L1 Gene

Selected SIMAP similar genes for SIPA1L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SIPA1L1: view

Variants for SIPA1L1 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs757744 -- 71,731,056(-) ACAGC(A/G)GTGCA intron-variant
rs757850 -- 71,549,289(-) ATGAT(C/G)AGGTG intron-variant
rs917193 -- 71,622,802(-) AGGAC(A/G)TGTTC intron-variant
rs1008517 -- 71,574,717(-) GTCTT(C/T)TTTTT intron-variant
rs1029537 -- 71,734,388(-) ACACA(G/T)ACTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L1 Gene

Variant ID Type Subtype PubMed ID
nsv85474 CNV Loss 16902084
esv32876 CNV Gain 17666407
nsv84708 CNV Loss 16902084

Relevant External Links for SIPA1L1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Disorders for SIPA1L1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SIPA1L1 Gene including...

Search for SIPA1L1 Gene in MalaCards »

Relevant External Links for SIPA1L1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with SIPA1L1: view

No data available for UniProtKB/Swiss-Prot for SIPA1L1 Gene

Publications for SIPA1L1 Gene

  1. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. (PMID: 9858596) Gao Q. … Band V. (Mol. Cell. Biol. 1999) 2 3 4 23
  2. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. (PMID: 16999984) Lee C. … Laimins L.A. (Virology 2007) 3 23
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SIPA1L1 Gene

  • antibodies-online peptides for SIPA1L1
  • antibodies-online antibodies for SIPA1L1
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Sources for SIPA1L1 Gene

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