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SIPA1L1 Gene

protein-coding   GIFtS: 57
GCID: GC14P071787

Signal-Induced Proliferation-Associated 1 Like 1

  See SIPA1L1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal-Induced Proliferation-Associated 1 Like 11 2     Signal-Induced Proliferation-Associated 1-Like Protein 12
High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 12 3     KIAA04403
E6TP12 3     E6-Targeted Protein 13
SIPA1-Like Protein 12 3     

External Ids:    HGNC: 202841   Entrez Gene: 260372   Ensembl: ENSG000001975557   UniProtKB: O431663   
ORGUL members:         

Export aliases for SIPA1L1 gene to outside databases

Previous GC identifers: GC14P069987 GC14P069988 GC14P071065 GC14P071996 GC14P052162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIPA1L1 Gene:
SIPA1L1 (signal-induced proliferation-associated 1 like 1) is a protein-coding gene. Diseases associated with SIPA1L1 include papilloma. GO annotations related to this gene include ephrin receptor binding and GTPase activator activity. An important paralog of this gene is SIPA1.

UniProtKB/Swiss-Prot: SI1L1_HUMAN, O43166
Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits
DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)

Gene Wiki entry for SIPA1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIPA1L1 gene promoter:
         MEF-2   CUTL1   MEF-2A   S8   IRF-7A   FOXO1a   aMEF-2   En-1   FOXO1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIPA1L1 promoter sequence
   Search Chromatin IP Primers for SIPA1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIPA1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.1

SIPA1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIPA1L1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P071787:  view genomic region     (about GC identifiers)

Start:
71,787,166 bp from pter      End:
72,207,946 bp from pter
Size:
420,781 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SI1L1_HUMAN, O43166 (See protein sequence)
Recommended Name: Signal-induced proliferation-associated 1-like protein 1  
Size: 1804 amino acids; 200029 Da
Subunit: Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity).
Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the
RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6
Sequence caution: Sequence=BAA23712.2; Type=Erroneous initiation;
Secondary accessions: O95321 Q9UDU4 Q9UNU4
Alternative splicing: 2 isoforms:  O43166-1   O43166-2   

Explore the universe of human proteins at neXtProt for SIPA1L1: NX_O43166

Explore proteomics data for SIPA1L1 at MOPED

Post-translational modifications: 

  • Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2 (By similarity)1
  • Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2
    binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIPA1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001271174.1  NP_001271175.1  NP_001271176.1  NP_056371.1  

    ENSEMBL proteins: 
     ENSP00000452080   ENSP00000370630   ENSP00000450832   ENSP00000351352   ENSP00000440682  
     ENSP00000452450  

    SIPA1L1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SIPA1L1

     
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    antibodies-online peptides for SIPA1L1

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    antibodies-online kits for SIPA1L1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001478 PDZ
     IPR000331 Rap_GAP_dom
     IPR021818 DUF3401

    Graphical View of Domain Structure for InterPro Entry O43166

    ProtoNet protein and cluster: O43166

    1 Blocks protein domain: IPB000331 Rap/ran-GAP

    UniProtKB/Swiss-Prot: SI1L1_HUMAN, O43166
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 Rap-GAP domain


    Find genes that share domains with SIPA1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SI1L1_HUMAN, O43166
    Function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits
    DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
    GO:0046875ephrin receptor binding IEA--
         
    Find genes that share ontologies with SIPA1L1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SIPA1L1

    miRNA
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    miRTarBase miRNAs that target SIPA1L1:
    hsa-mir-92a-3p (MIRT049597)

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    4 qRT-PCR Assays for microRNAs that regulate SIPA1L1:
    hsa-miR-374b* hsa-miR-1283 hsa-miR-4282 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidSIPA1L1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SI1L1_HUMAN, O43166: Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse, postsynaptic cell membrane,
    postsynaptic density (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Associated with
    the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--
    GO:0014069postsynaptic density ISS--
    GO:0030054cell junction IEA--
    GO:0043197dendritic spine ISS--

    Find genes that share ontologies with SIPA1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIPA1L1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Rap1 signaling pathway0.36


    Find genes that share SuperPaths with SIPA1L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SIPA1L1):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIPA1L1
    Interactions:

        Search GeneGlobe Interaction Network for SIPA1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SIPA1L1 (O431662, 3 ENSP000003513524) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG4P783522, 3MINT-8305428 I2D: score=2 
    SFNP319472, 3MINT-3975301 I2D: score=2 
    CEBPEQ157443, ENSP000002065134I2D: score=3 STRING: ENSP00000206513
    NRXN1Q9ULB13, ENSP000003851424I2D: score=3 STRING: ENSP00000385142
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0031532actin cytoskeleton reorganization ISS--
    GO:0032317regulation of Rap GTPase activity ISS--
    GO:0032861activation of Rap GTPase activity ISS--
    GO:0048013ephrin receptor signaling pathway ISS--

    Find genes that share ontologies with SIPA1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIPA1L1 (SI1L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIPA1L1 gene (4 alternative transcripts): 
    NM_001284245.1  NM_001284246.1  NM_001284247.1  NM_015556.2  

    Unigene Cluster for SIPA1L1:

    Signal-induced proliferation-associated 1 like 1
    Hs.654657  [show with all ESTs]
    Unigene Representative Sequence: AK122930
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553453 ENST00000555989 ENST00000556408 ENST00000554126 ENST00000556780
    ENST00000554362 ENST00000555652 ENST00000557151 ENST00000557469 ENST00000557712(uc001xmr.1)
    ENST00000381232(uc001xmt.3) ENST00000555818(uc001xms.3 uc001xmv.3)
    ENST00000358550(uc001xmu.3) ENST00000537413(uc010ttm.2) ENST00000555066
    ENST00000554960 ENST00000554874 ENST00000556959
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      QuantiFast Probe-based Assays in human, mouse, rat SIPA1L1

    Additional mRNA sequence: 

    AB007900.2 AF090989.1 AF090990.1 AK094532.1 AK122930.1 AK302650.1 BC033950.2 BC146777.1 
    CR936651.1 

    18 DOTS entries:

    DT.100649905  DT.92430773  DT.100649906  DT.101974659  DT.91732500  DT.70104680  DT.40108074  DT.100706264 
    DT.120772965  DT.405444  DT.95081724  DT.120772948  DT.120773003  DT.100653028  DT.120772934  DT.40106672 
    DT.86844822  DT.95150548 

    Selected AceView cDNA sequences (see all 189):

    AI582730 AI498104 AL707661 BM987928 BF890751 BQ927153 BQ019460 CR612092 
    AL119011 BU622384 AF090989 BP337149 AK122930 BE272281 AW296953 BM679416 
    BQ015905 BQ014925 BM782153 AI057021 BX457320 BU956798 NM_015556 BM846206 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                            -     -                                                         

    ExUns: 20b ^ 21 ^ 22
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SIPA1L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIPA1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTAGGGAA
    SIPA1L1 Expression
    About this image


    SIPA1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    SIPA1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIPA1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654657

    UniProtKB/Swiss-Prot: SI1L1_HUMAN, O43166
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIPA1L1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sipa1l11 , 5 signal-induced proliferation-associated 1 like 11, 5 88.57(n)1
    95.85(a)1
      12 (38.14 cM)5
    2176921  NM_172579.31  NP_766167.21 
     821700165 
    chicken
    (Gallus gallus)
    Aves SIPA1L11 signal-induced proliferation-associated 1 like 1 81.2(n)
    90.43(a)
      423255  NM_001199690.1  NP_001186619.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIPA1L16
    signal-induced proliferation-associated 1 like 1
    87(a)
    1 ↔ 1
    1(37958536-38135119)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ399465.12   -- 74.05(n)    BQ399465.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD594418.12   -- 73.93(n)   321066  CD594418.1 


    ENSEMBL Gene Tree for SIPA1L1 (if available)
    TreeFam Gene Tree for SIPA1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIPA1L1 gene
    SIPA12  SIPA1L32  RAP1GAP2  SIPA1L22  GARNL32  RAP1GAP22  
    5 SIMAP similar genes for SIPA1L1 using alignment to 6 protein entries:     SI1L1_HUMAN (see all proteins):
    DKFZp686G1344    SIPA1L2    SIPA1L3    RAP1GAP    SIPA1

    Find genes that share paralogs with SIPA1L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIPA1L1 (see all 3694)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355494
    A breast cancer sample4--see VAR_0355492 E D mis40--------
    rs764169681,2
    C,F--52983993(+) ATTTTT/CATTTT 1 -- us2k12Minor allele frequency- C:0.06CSA WA 120
    rs1842026841,2
    --52984170(+) TCTTAC/TTAATT 1 -- us2k10--------
    rs1142908621,2
    C,F--52984179(+) TTTGTA/GAGGAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1127580731,2
    C--52984285(+) AAAAAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1170260571,2
    F--52984631(+) GCTCCG/ACCTCC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1410582401,2
    --52984647(+) TCAAGC/TGATTT 1 -- us2k10--------
    rs1449190041,2
    --52984704(+) TGTACC/TGGCTA 1 -- us2k10--------
    rs1475751531,2
    --52984786(+) TTCAGC/TACTCC 1 -- us2k10--------
    rs1158801561,2
    F--52984992(+) AGACTA/GCATGA 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for SIPA1L1 (71787166 - 72037166 bp, first 250kb of SIPA1L1)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SIPA1L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv85474CNV Loss16902084
    nsv84708CNV Loss16902084
    esv32876CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIPA1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIPA1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SIPA1L1:    
    About MalaCards
    papilloma


    Find genes that share disorders with SIPA1L1           About GenesLikeMe

    Genetic Association Database (GAD): SIPA1L1

    Export disorders for SIPA1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIPA1L1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SIPA1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. (PubMed id 9858596)1, 2, 3, 9 Gao Q.... Band V. (Mol. Cell. Biol. 1999)
    2. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    7. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. (PubMed id 16999984)1, 9 Lee C....Laimins L.A. (Virology 2007)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26037 HGNC: 20284 AceView: SIPA1L1 Ensembl:ENSG00000197555 euGenes: HUgn26037
    ECgene: SIPA1L1 Kegg: 26037 H-InvDB: SIPA1L1

    (According to HUGE)
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    HUGE: KIAA0440

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIPA1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIPA1L1 gene:
    Search GeneIP for patents involving SIPA1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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