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Aliases for SIPA1L1 Gene

Aliases for SIPA1L1 Gene

  • Signal Induced Proliferation Associated 1 Like 1 2 3 5
  • High-Risk Human Papilloma Viruses E6 Oncoproteins Targeted Protein 1 3 4
  • SIPA1-Like Protein 1 3 4
  • E6TP1 3 4
  • Signal-Induced Proliferation-Associated 1-Like Protein 1 3
  • Signal-Induced Proliferation-Associated 1 Like 1 2
  • E6-Targeted Protein 1 4
  • KIAA0440 4

External Ids for SIPA1L1 Gene

Previous GeneCards Identifiers for SIPA1L1 Gene

  • GC14P069987
  • GC14P069988
  • GC14P071065
  • GC14P071996
  • GC14P052162
  • GC14P071787

Summaries for SIPA1L1 Gene

GeneCards Summary for SIPA1L1 Gene

SIPA1L1 (Signal Induced Proliferation Associated 1 Like 1) is a Protein Coding gene. Diseases associated with SIPA1L1 include Papilloma. Among its related pathways are Protein-protein interactions at synapses and Ras signaling pathway. GO annotations related to this gene include GTPase activator activity and ephrin receptor binding. An important paralog of this gene is SIPA1L2.

UniProtKB/Swiss-Prot for SIPA1L1 Gene

  • Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Gene Wiki entry for SIPA1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1L1 Gene

Genomics for SIPA1L1 Gene

Regulatory Elements for SIPA1L1 Gene

Enhancers for SIPA1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G071354 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19 +39.8 39808 11.9 PKNOX1 ATF1 ARNT FEZF1 TCF12 ZNF766 GATA2 ZNF143 JUNB TBX21 SIPA1L1 SNORD56B PCNX1 LOC102724015 GC14M071365 GC14M071331
GH14G071140 1.5 Ensembl ENCODE dbSUPER 11.2 -177.2 -177151 4.8 ZFP64 GATA2 CBX5 FOS REST ZNF623 TBX21 ZNF518A MIER3 SMARCA4 PCNX1 ADAM20 SIPA1L1 MED6 ADAM21 ADAM20P1 ENSG00000269927 ENSG00000259907
GH14G071582 1.4 FANTOM5 Ensembl ENCODE 10.8 +262.9 262932 2.5 PKNOX1 BACH1 GATA3 CTBP1 ZFHX2 CBX5 EED ETV6 FOS FOSL2 SIPA1L1 LOC102724015 GC14M071570 GC14M071550
GH14G071397 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +78.9 78876 4.2 TBP BACH1 BMI1 EBF1 ZBTB40 RELA ARID3A POLR2A EED RELB PCNX1 SIPA1L1 LOC102724015 SNORD56B GC14P071408
GH14G071752 1.1 Ensembl ENCODE 11.4 +432.8 432807 1.1 RB1 NFIB KLF17 ZNF2 RAD21 RFX5 GLIS2 ZNF143 RCOR1 ZNF391 SIPA1L1 GC14P071740 GC14M071838
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIPA1L1 on UCSC Golden Path with GeneCards custom track

Promoters for SIPA1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070414 751 2801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 FOS ZNF263

Genomic Location for SIPA1L1 Gene

Chromosome:
14
Start:
71,320,449 bp from pter
End:
71,741,229 bp from pter
Size:
420,781 bases
Orientation:
Plus strand

Genomic View for SIPA1L1 Gene

Genes around SIPA1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1L1 Gene

Proteins for SIPA1L1 Gene

  • Protein details for SIPA1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43166-SI1L1_HUMAN
    Recommended name:
    Signal-induced proliferation-associated 1-like protein 1
    Protein Accession:
    O43166
    Secondary Accessions:
    • J3KP19
    • O95321
    • Q9UDU4
    • Q9UNU4

    Protein attributes for SIPA1L1 Gene

    Size:
    1804 amino acids
    Molecular mass:
    200029 Da
    Quaternary structure:
    • Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
    SequenceCaution:
    • Sequence=BAA23712.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIPA1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIPA1L1 Gene

Post-translational modifications for SIPA1L1 Gene

  • Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).
  • Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SIPA1L1

No data available for DME Specific Peptides for SIPA1L1 Gene

Domains & Families for SIPA1L1 Gene

Gene Families for SIPA1L1 Gene

Protein Domains for SIPA1L1 Gene

Suggested Antigen Peptide Sequences for SIPA1L1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIPA1L1: view

No data available for UniProtKB/Swiss-Prot for SIPA1L1 Gene

Function for SIPA1L1 Gene

Molecular function for SIPA1L1 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity IEA --
GO:0046875 ephrin receptor binding IEA --
genes like me logo Genes that share ontologies with SIPA1L1: view

Phenotypes for SIPA1L1 Gene

genes like me logo Genes that share phenotypes with SIPA1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIPA1L1 Gene

Localization for SIPA1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIPA1L1 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 4
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density ISS --
genes like me logo Genes that share ontologies with SIPA1L1: view

Pathways & Interactions for SIPA1L1 Gene

genes like me logo Genes that share pathways with SIPA1L1: view

Pathways by source for SIPA1L1 Gene

Gene Ontology (GO) - Biological Process for SIPA1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031532 actin cytoskeleton reorganization IEA,ISS --
GO:0043087 regulation of GTPase activity ISS,IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048013 ephrin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with SIPA1L1: view

No data available for SIGNOR curated interactions for SIPA1L1 Gene

Transcripts for SIPA1L1 Gene

Unigene Clusters for SIPA1L1 Gene

Signal-induced proliferation-associated 1 like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1:
SP2: -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:

ExUns: 20b ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SIPA1L1 Gene

GeneLoc Exon Structure for
SIPA1L1
ECgene alternative splicing isoforms for
SIPA1L1

Expression for SIPA1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIPA1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIPA1L1 Gene

This gene is overexpressed in Kidney (21.5), Bone marrow mesenchymal stem cell (9.8), Peripheral blood mononuclear cells (6.6), and Spleen (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIPA1L1 Gene



Protein tissue co-expression partners for SIPA1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIPA1L1 Gene:

SIPA1L1

SOURCE GeneReport for Unigene cluster for SIPA1L1 Gene:

Hs.654657

mRNA Expression by UniProt/SwissProt for SIPA1L1 Gene:

O43166-SI1L1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SIPA1L1 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SIPA1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIPA1L1 Gene

Orthologs for SIPA1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIPA1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIPA1L1 34 35
  • 99.58 (n)
oppossum
(Monodelphis domestica)
Mammalia SIPA1L1 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIPA1L1 34 35
  • 90.3 (n)
dog
(Canis familiaris)
Mammalia SIPA1L1 34 35
  • 90.26 (n)
mouse
(Mus musculus)
Mammalia Sipa1l1 34 16 35
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Sipa1l1 34
  • 88.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SIPA1L1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIPA1L1 34 35
  • 81.2 (n)
lizard
(Anolis carolinensis)
Reptilia SIPA1L1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1l1 34
  • 73.18 (n)
zebrafish
(Danio rerio)
Actinopterygii sipa1l1 34 35
  • 63.06 (n)
-- 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8585 34
Species where no ortholog for SIPA1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1L1 Gene

ENSEMBL:
Gene Tree for SIPA1L1 (if available)
TreeFam:
Gene Tree for SIPA1L1 (if available)

Paralogs for SIPA1L1 Gene

(5) SIMAP similar genes for SIPA1L1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SIPA1L1: view

Variants for SIPA1L1 Gene

Sequence variations from dbSNP and Humsavar for SIPA1L1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035549 A breast cancer sample
rs1000008435 -- 71,448,418(+) AGAGA(A/G)GTTAA intron-variant
rs1000010732 -- 71,576,368(+) GTGAG(A/C)TAATG intron-variant
rs1000025520 -- 71,668,478(+) ACAAG(A/G)CACCT intron-variant
rs1000045249 -- 71,668,283(+) TCCTC(A/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIPA1L1 Gene

Variant ID Type Subtype PubMed ID
esv32876 CNV gain 17666407
esv3337405 CNV insertion 20981092
esv3551741 CNV deletion 23714750
esv3634880 CNV loss 21293372
nsv1160197 CNV duplication 26073780
nsv84708 CNV deletion 16902084
nsv85474 CNV deletion 16902084

Variation tolerance for SIPA1L1 Gene

Residual Variation Intolerance Score: 0.771% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIPA1L1 Gene

Human Gene Mutation Database (HGMD)
SIPA1L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIPA1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1L1 Gene

Disorders for SIPA1L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIPA1L1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
papilloma
  • papillomatosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIPA1L1

Genetic Association Database (GAD)
SIPA1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIPA1L1
genes like me logo Genes that share disorders with SIPA1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIPA1L1 Gene

Publications for SIPA1L1 Gene

  1. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. (PMID: 9858596) Gao Q. … Band V. (Mol. Cell. Biol. 1999) 2 3 4 22 64
  2. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PMID: 21076409) Sotoodehnia N. … Arking D.E. (Nat. Genet. 2010) 3 46 64
  3. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. (PMID: 16999984) Lee C. … Laimins L.A. (Virology 2007) 3 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SIPA1L1 Gene

Sources for SIPA1L1 Gene

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