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Aliases for SIPA1 Gene

Aliases for SIPA1 Gene

  • Signal-Induced Proliferation-Associated 1 2 3 5
  • GTPase-Activating Protein Spa-1 3 4
  • P130 SPA-1 3 4
  • Sipa-1 3 4
  • SPA1 3 4
  • Signal-Induced Proliferation-Associated Gene 1 3

External Ids for SIPA1 Gene

Previous GeneCards Identifiers for SIPA1 Gene

  • GC11U990125
  • GC11P067087
  • GC11P065655
  • GC11P065180
  • GC11P065162
  • GC11P065102
  • GC11P065406
  • GC11P061734
  • GC11P065410

Summaries for SIPA1 Gene

Entrez Gene Summary for SIPA1 Gene

  • The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIPA1 Gene

SIPA1 (Signal-Induced Proliferation-Associated 1) is a Protein Coding gene. Among its related pathways are Immune System and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include GTPase activator activity and protein C-terminus binding. An important paralog of this gene is RAP1GAP.

UniProtKB/Swiss-Prot for SIPA1 Gene

  • GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Gene Wiki entry for SIPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1 Gene

Genomics for SIPA1 Gene

Regulatory Elements for SIPA1 Gene

Enhancers for SIPA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIPA1 Gene

65,585,395 bp from pter
65,650,930 bp from pter
65,536 bases
Plus strand

Genomic View for SIPA1 Gene

Genes around SIPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1 Gene

Proteins for SIPA1 Gene

  • Protein details for SIPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • O14518
    • O60484
    • O60618
    • Q2YD83

    Protein attributes for SIPA1 Gene

    1042 amino acids
    Molecular mass:
    112149 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIPA1 Gene

Proteomics data for SIPA1 Gene at MOPED

Post-translational modifications for SIPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIPA1 Gene

Domains & Families for SIPA1 Gene

Gene Families for SIPA1 Gene

Protein Domains for SIPA1 Gene


Suggested Antigen Peptide Sequences for SIPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with SIPA1: view

Function for SIPA1 Gene

Molecular function for SIPA1 Gene

GENATLAS Biochemistry:
signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog
UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
UniProtKB/Swiss-Prot Induction:
Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Gene Ontology (GO) - Molecular Function for SIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 21988832
genes like me logo Genes that share ontologies with SIPA1: view
genes like me logo Genes that share phenotypes with SIPA1: view

Animal Models for SIPA1 Gene

MGI Knock Outs for SIPA1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIPA1 Gene

Localization for SIPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIPA1 Gene

Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.

Subcellular locations from

Jensen Localization Image for SIPA1 Gene COMPARTMENTS Subcellular localization image for SIPA1 gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 2
plasma membrane 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SIPA1 Gene

Pathways & Interactions for SIPA1 Gene

genes like me logo Genes that share pathways with SIPA1: view

Pathways by source for SIPA1 Gene

1 BioSystems pathway for SIPA1 Gene
3 Reactome pathways for SIPA1 Gene
1 GeneGo (Thomson Reuters) pathway for SIPA1 Gene

Gene Ontology (GO) - Biological Process for SIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 12059963
GO:0007165 signal transduction TAS 9346962
GO:0043547 positive regulation of GTPase activity IEA,NAS 9346962
genes like me logo Genes that share ontologies with SIPA1: view

No data available for SIGNOR curated interactions for SIPA1 Gene

Drugs & Compounds for SIPA1 Gene

No Compound Related Data Available

Transcripts for SIPA1 Gene

Unigene Clusters for SIPA1 Gene

Signal-induced proliferation-associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1 Gene

No ASD Table

Relevant External Links for SIPA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1 Gene

mRNA expression in normal human tissues for SIPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIPA1 Gene

This gene is overexpressed in Whole Blood (x13.1) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for SIPA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Lymph node (10.7), and NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1 Gene

SOURCE GeneReport for Unigene cluster for SIPA1 Gene Hs.530477

mRNA Expression by UniProt/SwissProt for SIPA1 Gene

Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
genes like me logo Genes that share expression patterns with SIPA1: view

Protein tissue co-expression partners for SIPA1 Gene

Primer Products

Orthologs for SIPA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIPA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIPA1 35
  • 88.91 (n)
  • 90.58 (a)
SIPA1 36
  • 90 (a)
(Canis familiaris)
Mammalia SIPA1 35
  • 89.02 (n)
  • 90.75 (a)
SIPA1 36
  • 90 (a)
(Mus musculus)
Mammalia Sipa1 35
  • 84.94 (n)
  • 90.27 (a)
Sipa1 16
Sipa1 36
  • 90 (a)
(Pan troglodytes)
Mammalia SIPA1 35
  • 99.58 (n)
  • 100 (a)
SIPA1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sipa1 35
  • 84.04 (n)
  • 89.33 (a)
(Monodelphis domestica)
Mammalia SIPA1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SIPA1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SIPA1 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1 35
  • 54.4 (n)
  • 53.14 (a)
(Danio rerio)
Actinopterygii SIPA1 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18646 37
  • 36 (a)
Species with no ortholog for SIPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1 Gene

Gene Tree for SIPA1 (if available)
Gene Tree for SIPA1 (if available)

Paralogs for SIPA1 Gene

(3) SIMAP similar genes for SIPA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIPA1: view

Variants for SIPA1 Gene

Sequence variations from dbSNP and Humsavar for SIPA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35045265 - 65,641,160(+) CAGCC(A/G)ACCTG nc-transcript-variant, reference, missense
rs3741379 - 65,641,237(-) GAAGG(A/C)AGGCT nc-transcript-variant, reference, missense
rs34912782 - 65,641,443(+) GGTGA(C/G)CTAGG nc-transcript-variant, reference, missense
rs3741378 - 65,641,466(-) GTGGG(A/G)ATGCT nc-transcript-variant, reference, missense
rs746429 -- 65,649,963(-) CTGCC(C/T)GCCTC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SIPA1 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
nsv897748 CNV Loss 21882294
dgv1183n71 CNV Loss 21882294
dgv1184n71 CNV Loss 21882294
nsv897754 CNV Loss 21882294
nsv897755 CNV Gain 21882294

Variation tolerance for SIPA1 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIPA1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1 Gene

Disorders for SIPA1 Gene

Relevant External Links for SIPA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1 Gene

Publications for SIPA1 Gene

  1. Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (PMID: 19765277) Hsieh S.M. … Griffiths L.R. (BMC Cancer 2009) 3 23 48 67
  2. Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. (PMID: 15456879) Farina A. … Ozato K. (Mol. Cell. Biol. 2004) 3 23
  3. AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. (PMID: 12590145) Su L. … Minato N. (J. Biol. Chem. 2003) 3 23
  4. The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion. (PMID: 12091396) Liu L. … Harlan J.M. (J. Biol. Chem. 2002) 3 23
  5. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. (PMID: 10373454) Tsukamoto N. … Minato N. (J. Biol. Chem. 1999) 3 23

Products for SIPA1 Gene

Sources for SIPA1 Gene