Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIPA1 Gene

Aliases for SIPA1 Gene

  • Signal-Induced Proliferation-Associated 1 2 3 5
  • GTPase-Activating Protein Spa-1 3 4
  • P130 SPA-1 3 4
  • Sipa-1 3 4
  • SPA1 3 4
  • Signal-Induced Proliferation-Associated Protein 1 3
  • Signal-Induced Proliferation-Associated Gene 1 3

External Ids for SIPA1 Gene

Previous GeneCards Identifiers for SIPA1 Gene

  • GC11U990125
  • GC11P067087
  • GC11P065655
  • GC11P065180
  • GC11P065162
  • GC11P065102
  • GC11P065406
  • GC11P061734
  • GC11P065410
  • GC11P065585

Summaries for SIPA1 Gene

Entrez Gene Summary for SIPA1 Gene

  • The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIPA1 Gene

SIPA1 (Signal-Induced Proliferation-Associated 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include GTPase activator activity and protein C-terminus binding. An important paralog of this gene is SIPA1L2.

UniProtKB/Swiss-Prot for SIPA1 Gene

  • GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.

Gene Wiki entry for SIPA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1 Gene

Genomics for SIPA1 Gene

Regulatory Elements for SIPA1 Gene

Enhancers for SIPA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065650 2.1 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +14.6 14615 5.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 EIF1AD MAP3K11 ZFPL1 SIPA1 RNASEH2C LOC105369352 MRPL11 RBM14 KAT5 PCNX3
GH11G066078 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +443.7 443713 7.5 HDGF PKNOX1 FOXA2 AGO1 SIN3A YBX1 FEZF1 ZNF121 GATA2 CBX5 EIF1AD ENSG00000255320 SF3B2 SIPA1 RBM14 PACS1 ENSG00000258297 ZFPL1 PCNX3 KAT5
GH11G065609 1.7 FANTOM5 ENCODE dbSUPER 16.7 -24.1 -24099 8.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 MAP3K11 SIPA1 RNASEH2C CTSF LOC105369352 EIF1AD MRPL11 ZFPL1 SNX32 CTSW
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -213.9 -213916 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIPA1 on UCSC Golden Path with GeneCards custom track

Promoters for SIPA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040869 303 801 HDGF ATF1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A TCF12 ZNF143 ZNF207

Genomic Location for SIPA1 Gene

65,638,097 bp from pter
65,650,930 bp from pter
12,834 bases
Plus strand

Genomic View for SIPA1 Gene

Genes around SIPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIPA1 Gene

Proteins for SIPA1 Gene

  • Protein details for SIPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-induced proliferation-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • O14518
    • O60484
    • O60618
    • Q2YD83

    Protein attributes for SIPA1 Gene

    1042 amino acids
    Molecular mass:
    112149 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIPA1 Gene

Post-translational modifications for SIPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIPA1 Gene

No data available for DME Specific Peptides for SIPA1 Gene

Domains & Families for SIPA1 Gene

Gene Families for SIPA1 Gene

Protein Domains for SIPA1 Gene

Suggested Antigen Peptide Sequences for SIPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIPA1: view

No data available for UniProtKB/Swiss-Prot for SIPA1 Gene

Function for SIPA1 Gene

Molecular function for SIPA1 Gene

GENATLAS Biochemistry:
signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog
UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
UniProtKB/Swiss-Prot Induction:
Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Gene Ontology (GO) - Molecular Function for SIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity NAS 9346962
GO:0005515 protein binding IPI 21988832
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with SIPA1: view
genes like me logo Genes that share phenotypes with SIPA1: view

Animal Models for SIPA1 Gene

MGI Knock Outs for SIPA1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIPA1 Gene

Localization for SIPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIPA1 Gene

Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIPA1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC,IEA 9183624
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SIPA1: view

Pathways & Interactions for SIPA1 Gene

genes like me logo Genes that share pathways with SIPA1: view

Pathways by source for SIPA1 Gene

1 BioSystems pathway for SIPA1 Gene
3 Reactome pathways for SIPA1 Gene
1 GeneGo (Thomson Reuters) pathway for SIPA1 Gene

Gene Ontology (GO) - Biological Process for SIPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 12059963
GO:0007162 negative regulation of cell adhesion NAS 10373454
GO:0007165 signal transduction TAS 9346962
GO:0008283 cell proliferation TAS 9346962
GO:0030308 negative regulation of cell growth NAS 9183624
genes like me logo Genes that share ontologies with SIPA1: view

No data available for SIGNOR curated interactions for SIPA1 Gene

Transcripts for SIPA1 Gene

Unigene Clusters for SIPA1 Gene

Signal-induced proliferation-associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIPA1 Gene

No ASD Table

Relevant External Links for SIPA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIPA1 Gene

This gene is overexpressed in Whole Blood (x13.1) and Spleen (x4.8).

Protein differential expression in normal tissues from HIPED for SIPA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Lymph node (10.7), and NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIPA1 Gene

Protein tissue co-expression partners for SIPA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIPA1 Gene:


SOURCE GeneReport for Unigene cluster for SIPA1 Gene:


mRNA Expression by UniProt/SwissProt for SIPA1 Gene:

Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Evidence on tissue expression from TISSUES for SIPA1 Gene

  • Liver(4.2)
  • Blood(4.1)
  • Pancreas(4.1)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with SIPA1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIPA1 Gene

Orthologs for SIPA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIPA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIPA1 34 35
  • 99.58 (n)
(Canis familiaris)
Mammalia SIPA1 34 35
  • 89.02 (n)
(Bos Taurus)
Mammalia SIPA1 34 35
  • 88.91 (n)
(Mus musculus)
Mammalia Sipa1 34 16 35
  • 84.94 (n)
(Rattus norvegicus)
Mammalia Sipa1 34
  • 84.04 (n)
(Monodelphis domestica)
Mammalia SIPA1 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SIPA1 35
  • 66 (a)
(Anolis carolinensis)
Reptilia SIPA1 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sipa1 34
  • 54.4 (n)
(Danio rerio)
Actinopterygii SIPA1 35
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18646 36
  • 36 (a)
Species where no ortholog for SIPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIPA1 Gene

Gene Tree for SIPA1 (if available)
Gene Tree for SIPA1 (if available)

Paralogs for SIPA1 Gene

(3) SIMAP similar genes for SIPA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIPA1: view

Variants for SIPA1 Gene

Sequence variations from dbSNP and Humsavar for SIPA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000581449 -- 65,649,197(+) GGGGG(G/T)GGGGC intron-variant, nc-transcript-variant
rs1000713922 -- 65,647,355(+) GCAGC(C/G/T)CCGCC intron-variant, upstream-variant-2KB
rs1000744800 -- 65,647,589(+) TGCCC(A/G)GCTCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1001329028 -- 65,645,725(+) GGCTG(A/G)TGGCA intron-variant
rs1001481748 -- 65,639,403(+) CGCAC(C/T)CGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIPA1 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
nsv951018 CNV deletion 24416366

Variation tolerance for SIPA1 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIPA1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1 Gene

Disorders for SIPA1 Gene

Relevant External Links for SIPA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIPA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1 Gene

Publications for SIPA1 Gene

  1. Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (PMID: 19765277) Hsieh S.M. … Griffiths L.R. (BMC Cancer 2009) 3 22 46 64
  2. Genomic organization and cloning of the human homologue of murine Sipa-1. (PMID: 9651531) Ebrahimi S. … Sawicki M.P. (Gene 1998) 3 4 22 64
  3. Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PMID: 9346962) Kurachi H. … Minato N. (J. Biol. Chem. 1997) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer. (PMID: 19906411) Brooks R. … Rader J.S. (Gynecol. Oncol. 2010) 3 46 64

Products for SIPA1 Gene

Sources for SIPA1 Gene

Loading form....