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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIPA1 Gene

protein-coding GIFtS: 57
GCID: GC11P065410

signal-induced proliferation-associated 1

Explore 11 diseases affiliated with
SIPA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal-Induced Proliferation-Associated 1¹ ²		Signal-Induced Proliferation-Associated Gene 1²
SPA1¹ ² ³ ⁵		Signal-Induced Proliferation-Associated Protein 1²
GTPase-Activating Protein Spa-1² ³		Sipa-1³
P130 SPA-1² ³		Sipa-1³

External Ids:	HGNC: 10885¹	Entrez Gene: 6494²	Ensembl: ENSG00000213445⁷	OMIM: 602180⁵	UniProtKB: Q96FS4³

Export aliases for SIPA1 gene to outside databases

Previous GC identifers: GC11U990125 GC11P067087 GC11P065655 GC11P065180 GC11P065162 GC11P065102 GC11P065406 GC11P061734

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIPA1:

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for

Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper

mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear

region. Two alternatively spliced variants encoding the same isoform have been characterized to date. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the

putatively inactive GDP-bound state

Gene Wiki entry for SIPA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIPA1 gene promoter:
NF-1/L NF-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIPA1 promoter sequence

Search SABiosciences Chromatin IP Primers for SIPA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIPA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.3

SIPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIPA1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065410: view genomic region (about GC identifiers)

Start:	65,405,568 bp from pter	End:	65,418,401 bp from pter
Size:	12,834 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4 (See protein sequence)

Recommended Name: Signal-induced proliferation-associated protein 1

Size: 1042 amino acids; 112149 Da

Subcellular location: Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.

Note=Mostly localized in the perinuclear membraneous region

Secondary accessions: O14518 O60484 O60618 Q2YD83

Explore the universe of human proteins at neXtProt for SIPA1: NX_Q96FS4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96FS4

SIPA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006738.3 NP_694985.29

ENSEMBL proteins:

ENSP00000436269 ENSP00000436683 ENSP00000434362 ENSP00000433686 ENSP00000377771

ENSP00000377774

Reactome Protein details: Q96FS4
Human Recombinant Protein Products for SIPA1:

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	Uscn Proteins for SIPA1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IC	9183624
GO:0005829	cytosol	TAS	--
GO:0012505	endomembrane system	IEA	--
GO:0016020	membrane	IEA	--

SIPA1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIPA1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001478 PDZ

IPR000331 Rap_GAP_dom

Graphical View of Domain Structure for InterPro Entry Q96FS4

ProtoNet protein and cluster: Q96FS4

2 Blocks protein families:

IPB000331 Rap/ran-GAP

IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 Rap-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIPA1_HUMAN, Q96FS4

Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the

putatively inactive GDP-bound state

Induction: Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

Genatlas biochemistry entry for SIPA1:

signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid

tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	TAS	9346962
GO:0005515	protein binding	IPI	--
GO:0046582	Rap GTPase activator activity	NAS	9346962

SIPA1 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sipa1):

hematopoietic system

immune system

tumorigenesis

SIPA1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sipa1^tm1Nm for SIPA1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SIPA1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIPA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIPA1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SIPA1 (see all 10):
		hsa-miR-4324 hsa-miR-34c-5p hsa-miR-520d-5p hsa-miR-449b hsa-miR-486-3p hsa-miR-449a hsa-miR-544b hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: SIPA1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

G-protein signaling Rap1A regulation pathway

G-protein signaling Rap1A regulation pathway

1.00

G-protein signaling_Rap1A regulation pathway

0.88

Leukocyte transendothelial migration

Leukocyte transendothelial migration

1.00

Rap1 signalling

Rap1 signalling

1.00

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

MAPK Cascade

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SIPA1

G-protein signaling Rap1A regulation pathway

1 GeneGo (Thomson Reuters) Pathway for SIPA1

G-protein signaling Rap1A regulation pathway

1 BioSystems Pathway for SIPA1

MAPK Cascade

3 Reactome Pathways for SIPA1

	Adaptive Immune System
	Immune System
	Rap1 signalling

1 Kegg Pathway (Kegg details for SIPA1):

Leukocyte transendothelial migration

SIPA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIPA1

4 Interacting proteins for SIPA1 (Q96FS4^{1, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RFWD2	Q8NHY2³	I2D: score=2
AQP2	P41181³	I2D: score=1
BRD4	O60885³	I2D: score=1
CDKN1A	P38936¹	EBI-1054981,EBI-375077

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007010	cytoskeleton organization	NAS	12059963
GO:0007162	negative regulation of cell adhesion	NAS	10373454
GO:0007165	signal transduction	TAS	9346962
GO:0008283	cell proliferation	TAS	9346962
GO:0030308	negative regulation of cell growth	NAS	9183624

SIPA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIPA1
Search CenterWatch for drugs/clinical trials and news about SIPA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIPA1 gene (2 alternative transcripts):

NM_006747.3 NM_153253.29

Unigene Cluster for SIPA1:

Signal-induced proliferation-associated 1

Hs.530477 [show with all ESTs]

Unigene Representative Sequence: AB005666

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534313(uc001ofb.2) ENST00000533361 ENST00000526137 ENST00000527525(uc010rom.1)

ENST00000394224(uc001ofd.2) ENST00000534406 ENST00000530226 ENST00000531339

ENST00000529725 ENST00000528699 ENST00000394227

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIPA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIPA1
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SIPA1 (see all 10):
		hsa-miR-4324 hsa-miR-34c-5p hsa-miR-520d-5p hsa-miR-449b hsa-miR-486-3p hsa-miR-449a hsa-miR-544b hsa-miR-34a

		SwitchGear 3'UTR luciferase reporter plasmid: SIPA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB005666.1 AK303551.1 AK308234.1 AK310068.1 BC010492.1 BC110353.1

10 DOTS entries:

DT.113154 DT.100754646 DT.120707342 DT.120707318 DT.100686956 DT.100754645 DT.113155 DT.86839404

DT.86841102 DT.95357235

24/137 AceView cDNA sequences (see all 137):

BC010492 AI799994 AA064697 NM_153253 BX097170 BG756347 BE780730 T17351

BM973993 NM_006747 AI077341 BG686433 CA307167 AW576475 AL042880 BM971645

BM677738 BM725301 BF683752 BF976486 BI836054 BQ677201 BX453719 CB124905

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIPA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGGAAGC

About this image

SIPA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Epiblast-like cells (Reconstitution of mo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SIPA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIPA1

SOURCE GeneReport for Unigene cluster: Hs.530477

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such

as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord

SABiosciences Expression via Pathway-Focused PCR Array including SIPA1:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SIPA1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SIPA1⁶	--	50(a)	1 ↔ 1	GL344427.1(11278-31103)
zebrafish (Danio rerio)	Actinopterygii	FP236521.1⁶ CABZ01030262.1⁶	--	37(a) 14(a)	1 ↔ 1 possible ortholog	7(75563725-75616266) 13(49930493-49991643)
honey bee (Apis mellifera)	Insecta	--	--	21(a)	1 → many	Group4.4(204425-212055)
worm (Caenorhabditis elegans)	Secernentea	T27F2.2⁶	--	26(a)	1 → many	V(11631426-11637273)

ENSEMBL Gene Tree for SIPA1 (if available)
TreeFam Gene Tree for SIPA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIPA1 gene

SIPA1L3² SIPA1L1² RAP1GAP² SIPA1L2² GARNL3² RAP1GAP2²

3 SIMAP similar genes for SIPA1 using alignment to 3 protein entries: SIPA1_HUMAN (see all proteins):

SIPA1L2 SIPA1L3 SIPA1L1

SIPA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199551725^1,2	C	--	61730667(+)	`GCGGGA/GANNNN`	1	--	us2k¹		0	--	--	--	--
rs76759746^1,2	C,F	--	61731628(+)	`GTCCAG/AGGCCT`	1	--	us2k¹		1		EA	120
rs72556579^1,2	F	--	61732359(+)	`GCCTCC/TGCTAG`	1	--	us2k¹		6		MN WA	526
rs73490492^1,2	C	--	61743613(+)	`ATGCCG/CGGGAG`	2	--	int¹		1		WA	2
rs111934789^1,2		--	61743637(+)	`GGAAGC/TGAGCC`	2	--	int¹		1		CSA	2
rs200486439^1,2		--	65403606(+)	`CAGCCA/GTGTCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs201933055^1,2	C	--	65403858(+)	`CTCCTA/GCAGGC`	2	--	ds500¹ int¹		1		EU	485
rs144082298^1,2	C	--	65404176(+)	`TGTGGA/GAGGGT`	2	--	ds500¹ int¹		0	--	--	--	--
rs186802978^1,2		--	65404222(+)	`ACCTCG/TCCCCC`	2	--	int¹ ds500¹		0	--	--	--	--
rs117862438^1,2		--	65404492(+)	`GTAACG/TGACCT`	1	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for SIPA1 (65405568 - 65418401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIPA1: --
Human Gene Mutation Database (HGMD): SIPA1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIPA1

DNA2.0 Custom Variant and Variant Library Synthesis for SIPA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIPA1 for disorders           About GeneDecksing

OMIM gene information: 602180    OMIM disorders: --

11 diseases for SIPA1:    About MalaCards

metastasis efficiency, modification of metastasis efficiency juvenile myelomonocytic leukemia myelomonocytic leukemia

myeloproliferative disorder leukemia cervical cancer t-cell leukemia

cervicitis breast cancer thyroiditis

3 Novoseek disease relationships for SIPA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	46.6	2	17047059 (1), 15310461 (1)
myeloid leukemia chronic	43	2	17047059 (1), 15310461 (1)
tumors	0	2	14660640 (1), 12892713 (1)

Human Genome Epidemiology (HuGE) Navigator: SIPA1 (12 documents)

Export disorders for SIPA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SIPA1 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with SIPA1)

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Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PubMed id 9346962)^{1, 2, 9} Kurachi H.... Minato N. (1997)
Genomic organization and cloning of the human homologue of murine Sipa-1. (PubMed id 9651531)^{1, 2, 9} Ebrahimi S....Sawicki M.P. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. (PubMed id 9027487)^{1, 3} Wada Y....Minato N. (1997)
AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. (PubMed id 12590145)^{1, 9} Su L....Minato N. (2003)
Polymorphisms of the SIPA1 gene and sporadic breast c ancer susceptibility. (PubMed id 19765277)^{1, 9} Hsieh S.M....Griffiths L.R. (2009)
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. (PubMed id 15456879)^{1, 9} Farina A....Ozato K. (2004)
Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. (PubMed id 10373454)^{1, 9} Tsukamoto N....Minato N. (1999)
Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. (PubMed id 7799964)^{1, 9} Hattori M....Minato N. (1995)
The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion. (PubMed id 12091396)^{1, 9} Liu L....Harlan J.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6494	HGNC: 10885	AceView: SIPA1	Ensembl:ENSG00000213445	euGenes: HUgn6494
ECgene: SIPA1	Kegg: 6494	H-InvDB: SIPA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SIPA1	Pharmacogenomics, SNPs, Pathways

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signal-induced proliferation-associated 1

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signal-induced proliferation-associated 1

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