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SIPA1 Gene

protein-coding   GIFtS: 61
GCID: GC11P065410

Signal-Induced Proliferation-Associated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal-Induced Proliferation-Associated 11 2     Signal-Induced Proliferation-Associated Gene 12
SPA12 3 5     Signal-Induced Proliferation-Associated Protein 12
GTPase-Activating Protein Spa-12 3     sipa-12
P130 SPA-12 3     Sipa-13

External Ids:    HGNC: 108851   Entrez Gene: 64942   Ensembl: ENSG000002134457   OMIM: 6021805   UniProtKB: Q96FS43   

Export aliases for SIPA1 gene to outside databases

Previous GC identifers: GC11U990125 GC11P067087 GC11P065655 GC11P065180 GC11P065162 GC11P065102 GC11P065406 GC11P061734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIPA1 Gene:
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity
for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also
hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the
perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
(provided by RefSeq, Jul 2008)

GeneCards Summary for SIPA1 Gene:
SIPA1 (signal-induced proliferation-associated 1) is a protein-coding gene. Diseases associated with SIPA1 include metastasis efficiency, modification of, and myeloproliferative disorder. GO annotations related to this gene include Rap GTPase activator activity and GTPase activator activity. An important paralog of this gene is SIPA1L1.

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4
Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it
to the putatively inactive GDP-bound state

Gene Wiki entry for SIPA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIPA1 gene promoter:
         NF-1/L   NF-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIPA1 promoter sequence
   Search Chromatin IP Primers for SIPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.3

SIPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIPA1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065410:  view genomic region     (about GC identifiers)

Start:
65,405,568 bp from pter      End:
65,418,401 bp from pter
Size:
12,834 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4 (See protein sequence)
Recommended Name: Signal-induced proliferation-associated protein 1  
Size: 1042 amino acids; 112149 Da
Secondary accessions: O14518 O60484 O60618 Q2YD83

Explore the universe of human proteins at neXtProt for SIPA1: NX_Q96FS4

Explore proteomics data for SIPA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006738.3  NP_694985.29  

    ENSEMBL proteins: 
     ENSP00000436269   ENSP00000436683   ENSP00000434362   ENSP00000433686   ENSP00000377771  
     ENSP00000377774  
    Reactome Protein details: Q96FS4

    SIPA1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001478 PDZ
     IPR000331 Rap_GAP_dom

    Graphical View of Domain Structure for InterPro Entry Q96FS4

    ProtoNet protein and cluster: Q96FS4

    2 Blocks protein domains:
    IPB000331 Rap/ran-GAP
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 Rap-GAP domain


    SIPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIPA1_HUMAN, Q96FS4
    Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it
    to the putatively inactive GDP-bound state
    Induction: Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

         Genatlas biochemistry entry for SIPA1:
    signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid
    tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity TAS9346962
    GO:0005515protein binding IPI--
    GO:0008022protein C-terminus binding IEA--
    GO:0046582Rap GTPase activator activity NAS9346962
         
    SIPA1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sipa1):
     hematopoietic system  immune system  tumorigenesis 

    SIPA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sipa1tm1Nm for SIPA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIPA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIPA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIPA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIPA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SIPA1:
    hsa-mir-26b-5p (MIRT030296)

    Block miRNA regulation of human, mouse, rat SIPA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIPA1 (see all 10):
    hsa-miR-4324 hsa-miR-34c-5p hsa-miR-520d-5p hsa-miR-449b hsa-miR-486-3p hsa-miR-449a hsa-miR-544b hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidSIPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIPA1
    Predesigned siRNA for gene silencing in human, mouse, rat SIPA1

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SIPA1 (NM_006747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIPA1

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIPA1_HUMAN, Q96FS4: Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.
    Note=Mostly localized in the perinuclear membraneous region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC9183624
    GO:0005829cytosol TAS--
    GO:0012505endomembrane system ----
    GO:0016020membrane IEA--
    GO:0030133transport vesicle IEA--

    SIPA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIPA1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1G protein signaling Ras family GTPases in kinase cascades scheme
    MAPK Cascade0.44
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4Rap1 signalling
    Rap1 signalling
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SIPA1
        G-protein signaling Rap1A regulation pathway

    1 BioSystems Pathway for SIPA1
        MAPK Cascade

    1 Reactome Pathway for SIPA1
        Rap1 signalling


    2 Kegg Pathways  (Kegg details for SIPA1):
        Rap1 signaling pathway
    Leukocyte transendothelial migration


    SIPA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SIPA1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SIPA1

    4 Interacting proteins for SIPA1 (Q96FS41, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RFWD2Q8NHY23I2D: score=2 
    AQP2P411813I2D: score=1 
    BRD4O608853I2D: score=1 
    CDKN1AP389361EBI-1054981,EBI-375077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization NAS12059963
    GO:0007162negative regulation of cell adhesion NAS10373454
    GO:0007165signal transduction TAS9346962
    GO:0008283cell proliferation TAS9346962
    GO:0030308negative regulation of cell growth NAS9183624

    SIPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIPA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIPA1 gene (2 alternative transcripts): 
    NM_006747.3  NM_153253.29  

    Unigene Cluster for SIPA1:

    Signal-induced proliferation-associated 1
    Hs.530477  [show with all ESTs]
    Unigene Representative Sequence: AB005666
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534313(uc001ofb.2) ENST00000533361 ENST00000526137 ENST00000527525(uc010rom.1)
    ENST00000394224(uc001ofd.2) ENST00000534406 ENST00000530226 ENST00000531339
    ENST00000529725 ENST00000528699 ENST00000394227
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIPA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIPA1 (see all 10):
    hsa-miR-4324 hsa-miR-34c-5p hsa-miR-520d-5p hsa-miR-449b hsa-miR-486-3p hsa-miR-449a hsa-miR-544b hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidSIPA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SIPA1
    Predesigned siRNA for gene silencing in human, mouse, rat SIPA1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SIPA1 (NM_006747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIPA1
    Primer
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    OriGene qPCR primer pairs and template standards for SIPA1
    OriGene qSTAR qPCR primer pairs in human, mouse for SIPA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIPA1
      QuantiTect SYBR Green Assays in human, mouse, rat SIPA1
      QuantiFast Probe-based Assays in human, mouse, rat SIPA1

    Additional mRNA sequence: 

    AB005666.1 AK303551.1 AK308234.1 AK310068.1 BC010492.1 BC110353.1 

    10 DOTS entries:

    DT.113154  DT.100754646  DT.120707342  DT.120707318  DT.100686956  DT.100754645  DT.113155  DT.86839404 
    DT.86841102  DT.95357235 

    Selected AceView cDNA sequences (see all 137):

    BM725301 BE780730 BG756347 NM_006747 AI799994 BM971645 AL042880 BM677738 
    AA064697 CA307167 BC010492 AI077341 T17351 NM_153253 BM973993 BX097170 
    BG686433 AW576475 BG768250 AI560515 BE018149 BG338294 AI057185 AB005666 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGGAAGC
    SIPA1 Expression
    About this image


    SIPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
    SIPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530477

    UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4
    Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues
    such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal
    cord

        Pathway & Disease-focused RT2 Profiler PCR Array including SIPA1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SIPA1
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    QuantiFast Probe-based Assays in human, mouse, rat SIPA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIPA1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sipa11 , 5 signal-induced proliferation associated gene 11, 5 84.94(n)1
    90.27(a)1
      19 (4.34 cM)5
    204691  NM_001164480.11  NP_001157952.11 
     56511855 
    lizard
    (Anolis carolinensis)
    Reptilia SIPA16
    signal-induced proliferation-associated 1
    50(a)
    1 ↔ 1
    GL344427.1(11278-31103)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sipa11 signal-induced proliferation-associated 1 54.4(n)
    53.14(a)
      100490716  XM_002935362.2  XP_002935408.2 
    zebrafish
    (Danio rerio)
    Actinopterygii SIPA16
    signal-induced proliferation-associated 1
    38(a)
    1 ↔ 1
    7(75563725-75616266) ENSDARG00000076697


    ENSEMBL Gene Tree for SIPA1 (if available)
    TreeFam Gene Tree for SIPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SIPA1 gene
    SIPA1L12  SIPA1L32  RAP1GAP2  SIPA1L22  GARNL32  RAP1GAP22  
    3 SIMAP similar genes for SIPA1 using alignment to 3 protein entries:     SIPA1_HUMAN (see all proteins):
    SIPA1L2    SIPA1L3    SIPA1L1

    SIPA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIPA1 (see all 403)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004864391,2
    C--61730588(+) CAGCCA/GTGTCC 1 -- us2k10--------
    rs71140371,2
    C,F--61730633(+) CTTCAC/AAAGGG 1 -- us2k14Minor allele frequency- A:0.03NA NS 198
    rs617327271,2
    C,F--61730648(+) GGCGCC/TGGCTG 1 -- us2k13Minor allele frequency- T:0.09NS WA 194
    rs1995517251,2
    C--61730667(+) GCGGGA/GANNNN 1 -- us2k10--------
    rs2019330551,2
    C--61730840(+) CTCCTA/GCAGGC 1 -- us2k11Minor allele frequency- G:0.00EU 485
    rs2014189961,2
    C--61730951(+) CCCCTC/TGGCTC 1 -- us2k10--------
    rs772008591,2
    C,F--61731000(+) TCCCCG/AGACCT 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs2004368751,2
    C--61731069(+) GGGGGC/GCCGGA 1 -- us2k10--------
    rs1440822981,2
    C--61731158(+) TGTGGA/GAGGGT 1 -- us2k10--------
    rs1868029781,2
    C--61731204(+) ACCTCG/TCCCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIPA1 (65405568 - 65418401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIPA1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897723CNV Loss21882294
    nsv897754CNV Loss21882294
    nsv897748CNV Loss21882294
    dgv1175n71CNV Loss21882294
    dgv1180n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv1176n71CNV Loss21882294
    dgv1183n71CNV Loss21882294
    dgv1179n71CNV Loss21882294
    dgv1184n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SIPA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602180    OMIM disorders: --

    11 diseases for SIPA1:    
    About MalaCards
    metastasis efficiency, modification of    myeloproliferative disorder    sporadic breast cancer    cervical cancer
    t-cell leukemia    cervicitis    myeloid leukemia    leukemia
    colorectal cancer    thyroiditis    breast cancer


    SIPA1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SIPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloproliferative disorders 46.6 2 17047059 (1), 15310461 (1)
    myeloid leukemia chronic 43 2 17047059 (1), 15310461 (1)
    tumors 0 2 14660640 (1), 12892713 (1)

    Genetic Association Database (GAD): SIPA1
    Human Genome Epidemiology (HuGE) Navigator: SIPA1 (12 documents)

    Export disorders for SIPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIPA1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with SIPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (PubMed id 19765277)1, 4, 9 Hsieh S.M....Griffiths L.R. (BMC Cancer 2009)
    2. Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PubMed id 9346962)1, 2, 9 Kurachi H.... Minato N. (J. Biol. Chem. 1997)
    3. Genomic organization and cloning of the human homologue of murine Sipa-1. (PubMed id 9651531)1, 2, 9 Ebrahimi S....Sawicki M.P. (Gene 1998)
    4. Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer. (PubMed id 19906411)1, 4 Brooks R....Rader J.S. (Gynecol. Oncol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    7. Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis. (PubMed id 19089925)1, 4 Gaudet M.M....Garcia-Closas M. (Int. J. Cancer 2009)
    8. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    9. Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study. (PubMed id 19825179)1, 4 Hsieh S.M....Hunter K.W. (Breast Cancer Res. 2009)
    10. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. (PubMed id 16563182)1, 4 Crawford N.P....Hunter K.W. (Breast Cancer Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6494 HGNC: 10885 AceView: SIPA1 Ensembl:ENSG00000213445 euGenes: HUgn6494
    ECgene: SIPA1 Kegg: 6494 H-InvDB: SIPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIPA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SIPA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIPA1 gene:
    Search GeneIP for patents involving SIPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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