Aliases for SIPA1 Gene
Aliases for SIPA1 Gene
External Ids for SIPA1 Gene
- HGNC: 10885
- Entrez Gene: 6494
- Ensembl: ENSG00000213445
- OMIM: 602180
- UniProtKB: Q96FS4
Previous GeneCards Identifiers for SIPA1 Gene
- GC11U990125
- GC11P067087
- GC11P065655
- GC11P065180
- GC11P065162
- GC11P065102
- GC11P065406
- GC11P061734
- GC11P065410
- GC11P065585
Summaries for SIPA1 Gene
-
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIPA1 Gene
SIPA1 (Signal-Induced Proliferation-Associated 1) is a Protein Coding gene. Diseases associated with SIPA1 include Juvenile Myelomonocytic Leukemia. Among its related pathways are Innate Immune System and Rap1 signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and protein C-terminus binding. An important paralog of this gene is SIPA1L1.
UniProtKB/Swiss-Prot for SIPA1 Gene
-
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1 Gene
Genomics for SIPA1 Gene
GeneHancer (GH) Regulatory Elements for SIPA1 Gene
Promoters and enhancers for SIPA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SIPA1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SIPA1 Gene
Genomic Locations for SIPA1 Gene
- chr11:65,638,097-65,650,930
- (GRCh38/hg38)
- Size:
- 12,834 bases
- Orientation:
- Plus strand
- chr11:65,405,568-65,418,401
- (GRCh37/hg19)
Genomic View for SIPA1 Gene
Genes around SIPA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
SIPA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIPA1 Gene
Proteins for SIPA1 Gene
-
Protein details for SIPA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FS4-SIPA1_HUMAN
- Recommended name:
- Signal-induced proliferation-associated protein 1
- Protein Accession:
- Q96FS4
- O14518
- O60484
- O60618
- Q2YD83
Protein attributes for SIPA1 Gene
- Size:
- 1042 amino acids
- Molecular mass:
- 112149 Da
- Quaternary structure:
-
- Interacts with RRP1B; the interaction leads to inhibition of SIPA1 GTPase activity.
Protein Expression for SIPA1 Gene
Post-translational modifications for SIPA1 Gene
No Post-translational modifications
Other Protein References for SIPA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for SIPA1
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-
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Protein Products
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-
Abcam proteins for SIPA1
Assay Products
No data available for DME Specific Peptides for SIPA1 Gene
Domains & Families for SIPA1 Gene
Gene Families for SIPA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SIPA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIPA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SIPA1 Gene
Function for SIPA1 Gene
Molecular function for SIPA1 Gene
- GENATLAS Biochemistry:
- signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.
Phenotypes From GWAS Catalog for SIPA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | NAS | 9346962 |
| GO:0005515 | protein binding | IPI | 21988832 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
Phenotypes for SIPA1 Gene
- MGI mutant phenotypes for SIPA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SIPA1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Effect on mitosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Decreased viability with TRAIL
- Decreased viability with SS1P at EC30
Animal Models for SIPA1 Gene
- MGI Knock Outs for SIPA1:
-
- Sipa1 tm1Nm
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miRNA for SIPA1 Gene
- miRTarBase miRNAs that target SIPA1
-
- hsa-mir-26b-5p (MIRT030296)
- hsa-mir-6780a-5p (MIRT486298)
- hsa-mir-3689c (MIRT486299)
- hsa-mir-6779-5p (MIRT486300)
- hsa-mir-3689b-3p (MIRT486301)
- hsa-mir-3689a-3p (MIRT486302)
- hsa-mir-30b-3p (MIRT486303)
- hsa-mir-1273h-5p (MIRT486304)
- hsa-mir-7704 (MIRT486305)
- hsa-mir-6825-5p (MIRT486306)
- hsa-mir-6799-5p (MIRT486307)
- hsa-mir-6785-5p (MIRT486308)
- hsa-mir-6883-5p (MIRT486309)
- hsa-mir-4728-5p (MIRT486310)
- hsa-mir-149-3p (MIRT486311)
- hsa-mir-7106-5p (MIRT486312)
- hsa-mir-6787-5p (MIRT486313)
- hsa-mir-663a (MIRT486314)
- hsa-mir-1908-5p (MIRT486315)
- hsa-mir-766-5p (MIRT486316)
- hsa-mir-661 (MIRT486317)
- hsa-mir-6087 (MIRT486318)
- hsa-mir-3192-5p (MIRT486319)
- hsa-mir-542-5p (MIRT486320)
- hsa-mir-6777-5p (MIRT486321)
- hsa-mir-6889-5p (MIRT486322)
miRNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIPA1 Gene
Localization for SIPA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIPA1 Gene
- Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region. {ECO:0000269 PubMed:9346962}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Golgi apparatus (2)
- Nucleoli (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0012505 | endomembrane system | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for SIPA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 2 | Ras signaling pathway | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Rap1 signalling | ||
Pathways by source for SIPA1 Gene
1 BioSystems pathway for SIPA1 Gene
3 Reactome pathways for SIPA1 Gene
2 KEGG pathways for SIPA1 Gene
1 GeneGo (Thomson Reuters) pathway for SIPA1 Gene
Interacting Proteins for SIPA1 Gene
Selected Interacting proteins:
ENSP00000377771
Q96FS4-SIPA1_HUMAN
for SIPA1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | NAS | 12059963 |
| GO:0007162 | negative regulation of cell adhesion | NAS | 10373454 |
| GO:0007165 | signal transduction | TAS | 9346962 |
| GO:0008283 | cell proliferation | TAS | 9346962 |
| GO:0030308 | negative regulation of cell growth | NAS | 9183624 |
No data available for SIGNOR curated interactions for SIPA1 Gene
Transcripts for SIPA1 Gene
mRNA/cDNA for SIPA1 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SIPA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SIPA1
- genomics-online: gRNA clones - Search results for 126 available SIPA1 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIPA1
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for SIPA1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SIPA1
- Applied Biological Materials Clones for SIPA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SIPA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Epiblast (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for SIPA1 Gene
This gene is overexpressed in Whole Blood (x13.1) and Spleen (x4.8).
This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Lymph node (10.7), and NK cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIPA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SIPA1 Gene:
SIPA1SOURCE GeneReport for Unigene cluster for SIPA1 Gene:
Hs.530477mRNA Expression by UniProt/SwissProt for SIPA1 Gene:
Q96FS4-SIPA1_HUMAN
Tissue specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Evidence on tissue expression from TISSUES for SIPA1 Gene
- Liver(4.2)
- Blood(4.1)
- Pancreas(4.1)
- Lymph node(2.5)
Primer Products
-
OriGene qPCR primer pairs for SIPA1
-
OriGene qPCR primer pairs and template standards for SIPA1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIPA1 Gene
Orthologs for SIPA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SIPA1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SIPA1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SIPA1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Sipa1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sipa1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SIPA1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SIPA1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SIPA1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sipa1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | SIPA1 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG18646 35 |
|
|
- Species where no ortholog for SIPA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SIPA1 Gene
Variants for SIPA1 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000581449 | -- | 65,649,197(+) | T/C/G | intron_variant | |
| rs1000713922 | -- | 65,647,355(+) | C/G/T | intron_variant | |
| rs1000744800 | -- | 65,647,589(+) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1001329028 | -- | 65,645,725(+) | G/A | intron_variant | |
| rs1001481748 | -- | 65,639,403(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1969n54 | CNV | loss | 21841781 |
| nsv951018 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.67;
78.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIPA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1 Gene
Disorders for SIPA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| juvenile myelomonocytic leukemia |
|
|
Search SIPA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIPA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SIPA1 Gene
Publications for SIPA1 Gene
- Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (PMID: 19765277) Hsieh SM … Griffiths LR (BMC cancer 2009) 3 22 44 58
- Genomic organization and cloning of the human homologue of murine Sipa-1. (PMID: 9651531) Ebrahimi S … Sawicki MP (Gene 1998) 3 4 22 58
- Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product. (PMID: 9346962) Kurachi H … Minato N (The Journal of biological chemistry 1997) 3 4 22 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer. (PMID: 19906411) Brooks R … Rader JS (Gynecologic oncology 2010) 3 44 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SIPA1
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- Search for SIPA1 Proteins at ProSci
- Horizon Cell Lines for SIPA1
- genomics-online: cdna clones - Search results for 126 available SIPA1 gene related products
- Overview of 126 available SIPA1 gene related products
- orf clones - Search results for 126 available SIPA1 gene related products
- Overview of 126 available SIPA1 gene related products
- genomics-online: gRNA clones - Search results for 126 available SIPA1 gene related products
- Overview of 126 available SIPA1 gene related products
- genomics-online: primer clones - Search results for 126 available SIPA1 gene related products
- Overview of 126 available SIPA1 gene related products
- genomics-online: shRNA clones - Search results for 126 available SIPA1 gene related products
- Overview of 126 available SIPA1 gene related products
Sources for SIPA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew