Aliases for SIPA1 Gene
External Ids for SIPA1 Gene
Previous GeneCards Identifiers for SIPA1 Gene
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIPA1 Gene
SIPA1 (Signal-Induced Proliferation-Associated 1) is a Protein Coding gene. Diseases associated with SIPA1 include Juvenile Myelomonocytic Leukemia. Among its related pathways are Innate Immune System and Rap1 signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and protein C-terminus binding. An important paralog of this gene is SIPA1L1.
UniProtKB/Swiss-Prot for SIPA1 Gene
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).