Aliases for SIPA1 Gene
Aliases for SIPA1 Gene
External Ids for SIPA1 Gene
- HGNC: 10885
- Entrez Gene: 6494
- Ensembl: ENSG00000213445
- OMIM: 602180
- UniProtKB: Q96FS4
Previous GeneCards Identifiers for SIPA1 Gene
- GC11U990125
- GC11P067087
- GC11P065655
- GC11P065180
- GC11P065162
- GC11P065102
- GC11P065406
- GC11P061734
- GC11P065410
Summaries for SIPA1 Gene
-
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIPA1 Gene
SIPA1 (Signal-Induced Proliferation-Associated 1) is a Protein Coding gene. Among its related pathways are Immune System and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include GTPase activator activity and protein C-terminus binding. An important paralog of this gene is RAP1GAP.
UniProtKB/Swiss-Prot for SIPA1 Gene
-
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIPA1 Gene
Genomics for SIPA1 Gene
Regulatory Elements for SIPA1 Gene
Enhancers for SIPA1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around SIPA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SIPA1 gene promoter:
Regulatory Element Products
Genomic Location for SIPA1 Gene
- Chromosome:
- 11
- Start:
- 65,585,395 bp from pter
- End:
- 65,650,930 bp from pter
- Size:
- 65,536 bases
- Orientation:
- Plus strand
Genomic View for SIPA1 Gene
Genes around SIPA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13 by Entrez Gene
- 11q13.3 by HGNC
SIPA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIPA1 Gene
Proteins for SIPA1 Gene
-
Protein details for SIPA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96FS4-SIPA1_HUMAN
- Recommended name:
- Signal-induced proliferation-associated protein 1
- Protein Accession:
- Q96FS4
- O14518
- O60484
- O60618
- Q2YD83
Protein attributes for SIPA1 Gene
- Size:
- 1042 amino acids
- Molecular mass:
- 112149 Da
- Quaternary structure:
- No Data Available
Protein Expression for SIPA1 Gene
Post-translational modifications for SIPA1 Gene
Other Protein References for SIPA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SIPA1
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- antibodies-online Antibodies for SIPA1: See all 85
- GeneTex SIPA1 antibody for SIPA1
-
Custom Antibody ServicesProSci Antibodies for SIPA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIPA1
Protein Products
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Assay Products
- antibodies-online Kits for SIPA1: See all 3
No data available for DME Specific Peptides for SIPA1 Gene
Domains & Families for SIPA1 Gene
Gene Families for SIPA1 Gene
Protein Domains for SIPA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIPA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96FS4- Domain:
-
- Contains 1 PDZ (DHR) domain.
- Contains 1 Rap-GAP domain.
Function for SIPA1 Gene
Molecular function for SIPA1 Gene
- GENATLAS Biochemistry:
- signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog
- UniProtKB/Swiss-Prot Function:
- GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
- UniProtKB/Swiss-Prot Induction:
- Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 21988832 |
Phenotypes for SIPA1 Gene
- MGI mutant phenotypes for SIPA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SIPA1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Effect on mitosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Decreased viability with TRAIL
Animal Models for SIPA1 Gene
- MGI Knock Outs for SIPA1:
-
- Sipa1 tm1Nm
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SIPA1 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for SIPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIPA1
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miRNA for SIPA1 Gene
- miRTarBase miRNAs that target SIPA1
-
- hsa-mir-26b-5p (MIRT030296)
- hsa-mir-6780a-5p (MIRT486298)
- hsa-mir-3689c (MIRT486299)
- hsa-mir-6779-5p (MIRT486300)
- hsa-mir-3689b-3p (MIRT486301)
- hsa-mir-3689a-3p (MIRT486302)
- hsa-mir-30b-3p (MIRT486303)
- hsa-mir-1273h-5p (MIRT486304)
- hsa-mir-7704 (MIRT486305)
- hsa-mir-6825-5p (MIRT486306)
- hsa-mir-6799-5p (MIRT486307)
- hsa-mir-6785-5p (MIRT486308)
- hsa-mir-6883-5p (MIRT486309)
- hsa-mir-4728-5p (MIRT486310)
- hsa-mir-149-3p (MIRT486311)
- hsa-mir-7106-5p (MIRT486312)
- hsa-mir-6787-5p (MIRT486313)
- hsa-mir-663a (MIRT486314)
- hsa-mir-1908-5p (MIRT486315)
- hsa-mir-766-5p (MIRT486316)
- hsa-mir-661 (MIRT486317)
- hsa-mir-6087 (MIRT486318)
- hsa-mir-3192-5p (MIRT486319)
- hsa-mir-542-5p (MIRT486320)
- hsa-mir-6777-5p (MIRT486321)
- hsa-mir-6889-5p (MIRT486322)
miRNA Products
- Search ViGene Biosciences for SIPA1
Clone Products
- OriGene clones in human for SIPA1
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SIPA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SIPA1 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIPA1 Gene
Localization for SIPA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIPA1 Gene
- Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Note=Mostly localized in the perinuclear membraneous region.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 5 |
| golgi apparatus | 2 |
| plasma membrane | 2 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for SIPA1 Gene
Pathways & Interactions for SIPA1 Gene
More details on SuperPathways for SIPA1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Immune System |
.52
|
|
| 2 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 3 | Ras signaling pathway | ||
| 4 | Rap1 signalling | ||
| 5 | G-protein signaling_Rap1A regulation pathway |
Pathways by source for SIPA1 Gene
1 BioSystems pathway for SIPA1 Gene
3 Reactome pathways for SIPA1 Gene
2 KEGG pathways for SIPA1 Gene
1 GeneGo (Thomson Reuters) pathway for SIPA1 Gene
Interacting Proteins for SIPA1 Gene
Selected Interacting proteins:
ENSP00000377771
Q96FS4-SIPA1_HUMAN
for SIPA1 Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | NAS | 12059963 |
| GO:0007165 | signal transduction | TAS | 9346962 |
| GO:0043547 | positive regulation of GTPase activity | IEA,NAS | 9346962 |
No data available for SIGNOR curated interactions for SIPA1 Gene
Transcripts for SIPA1 Gene
mRNA/cDNA for SIPA1 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SIPA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SIPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIPA1
- GenScript: Design CRISPR guide RNA sequences for SIPA1
miRNA Products
- Search ViGene Biosciences for SIPA1
Clone Products
- OriGene clones in human for SIPA1
- OriGene ORF clones in human,mouse,rat for SIPA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SIPA1
Flow Cytometry Products
Expression for SIPA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Epiblast (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for SIPA1 Gene
This gene is overexpressed in Whole Blood (x13.1) and Spleen (x4.8).
This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Lymph node (10.7), and NK cells (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIPA1 Gene
SOURCE GeneReport for Unigene cluster for SIPA1 Gene Hs.530477
mRNA Expression by UniProt/SwissProt for SIPA1 Gene
Q96FS4-SIPA1_HUMAN
Tissue specificity:
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
Primer Products
-
OriGene qPCR primer pairs for SIPA1
-
OriGene qPCR primer pairs and template standards for SIPA1
Orthologs for SIPA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | SIPA1 35 |
|
||
| SIPA1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SIPA1 35 |
|
||
| SIPA1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Sipa1 35 |
|
||
| Sipa1 16 |
|
||||
| Sipa1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | SIPA1 35 |
|
||
| SIPA1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Sipa1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SIPA1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SIPA1 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SIPA1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sipa1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | SIPA1 36 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG18646 37 |
|
|
- Species with no ortholog for SIPA1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SIPA1 Gene
Paralogs for SIPA1 Gene
(3) SIMAP similar genes for SIPA1 Gene using alignment to 3 proteins:
Variants for SIPA1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs35045265 | - | 65,641,160(+) | CAGCC(A/G)ACCTG | nc-transcript-variant, reference, missense | |
| rs3741379 | - | 65,641,237(-) | GAAGG(A/C)AGGCT | nc-transcript-variant, reference, missense | |
| rs34912782 | - | 65,641,443(+) | GGTGA(C/G)CTAGG | nc-transcript-variant, reference, missense | |
| rs3741378 | - | 65,641,466(-) | GTGGG(A/G)ATGCT | nc-transcript-variant, reference, missense | |
| rs746429 | -- | 65,649,963(-) | CTGCC(C/T)GCCTC | nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1175n71 | CNV | Loss | 21882294 |
| nsv897718 | CNV | Loss | 21882294 |
| nsv897720 | CNV | Loss | 21882294 |
| dgv1176n71 | CNV | Loss | 21882294 |
| nsv897723 | CNV | Loss | 21882294 |
| dgv1179n71 | CNV | Loss | 21882294 |
| dgv1180n71 | CNV | Loss | 21882294 |
| nsv897736 | CNV | Loss | 21882294 |
| nsv897748 | CNV | Loss | 21882294 |
| dgv1183n71 | CNV | Loss | 21882294 |
| dgv1184n71 | CNV | Loss | 21882294 |
| nsv897754 | CNV | Loss | 21882294 |
| nsv897755 | CNV | Gain | 21882294 |
Residual Variation Intolerance Score:
74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.67;
78.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SIPA1 Gene
- Human Gene Mutation Database (HGMD)
- SIPA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIPA1 Gene
Disorders for SIPA1 Gene
Relevant External Links for SIPA1
No disorders were found for SIPA1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIPA1 Gene
Publications for SIPA1 Gene
- Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility. (PMID: 19765277) Hsieh S.M. … Griffiths L.R. (BMC Cancer 2009) 3 23 48 67
- Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. (PMID: 15456879) Farina A. … Ozato K. (Mol. Cell. Biol. 2004) 3 23
- AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. (PMID: 12590145) Su L. … Minato N. (J. Biol. Chem. 2003) 3 23
- The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion. (PMID: 12091396) Liu L. … Harlan J.M. (J. Biol. Chem. 2002) 3 23
- Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. (PMID: 10373454) Tsukamoto N. … Minato N. (J. Biol. Chem. 1999) 3 23
Products for SIPA1 Gene
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- antibodies-online Antibodies for SIPA1: See all 85
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- GeneTex SIPA1 antibody for SIPA1
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- ViGene Biosciences adenoviral particle packaged cDNA for SIPA1 gene
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Sources for SIPA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon