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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIPA1 Gene

protein-coding GIFtS: 61
GCID: GC11P065410

Signal-Induced Proliferation-Associated 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Signal-Induced Proliferation-Associated 1¹ ²		Signal-Induced Proliferation-Associated Gene 1²
SPA1² ³ ⁵		Signal-Induced Proliferation-Associated Protein 1²
GTPase-Activating Protein Spa-1² ³		sipa-1²
P130 SPA-1² ³		Sipa-1³

External Ids:	HGNC: 10885¹	Entrez Gene: 6494²	Ensembl: ENSG00000213445⁷	OMIM: 602180⁵	UniProtKB: Q96FS4³

Export aliases for SIPA1 gene to outside databases

Previous GC identifers: GC11U990125 GC11P067087 GC11P065655 GC11P065180 GC11P065162 GC11P065102 GC11P065406 GC11P061734

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIPA1 Gene:

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity

for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also

hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the

perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

(provided by RefSeq, Jul 2008)

GeneCards Summary for SIPA1 Gene:

SIPA1 (signal-induced proliferation-associated 1) is a protein-coding gene. Diseases associated with SIPA1 include juvenile myelomonocytic leukemia, and cervical cancer, and among its related super-pathways are Immune System and G-protein signaling Rap1A regulation pathway. GO annotations related to this gene include Rap GTPase activator activity and GTPase activator activity. An important paralog of this gene is SIPA1L1.

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it

to the putatively inactive GDP-bound state

Gene Wiki entry for SIPA1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NT_167190.1 NC_018922.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIPA1 gene promoter:
NF-1/L NF-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIPA1 promoter sequence

Search SABiosciences Chromatin IP Primers for SIPA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIPA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.3

SIPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIPA1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P065410: view genomic region (about GC identifiers)

Start:	65,405,568 bp from pter	End:	65,418,401 bp from pter
Size:	12,834 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4 (See protein sequence)

Recommended Name: Signal-induced proliferation-associated protein 1

Size: 1042 amino acids; 112149 Da

Subcellular location: Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein.

Note=Mostly localized in the perinuclear membraneous region

Secondary accessions: O14518 O60484 O60618 Q2YD83

Explore the universe of human proteins at neXtProt for SIPA1: NX_Q96FS4

Explore proteomics data for SIPA1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96FS4

SIPA1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_006738.3 NP_694985.29

ENSEMBL proteins:

ENSP00000436269 ENSP00000436683 ENSP00000434362 ENSP00000433686 ENSP00000377771

ENSP00000377774

Reactome Protein details: Q96FS4
Human Recombinant Protein Products for SIPA1:

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	9183624
GO:0005829	cytosol	TAS	--
GO:0012505	endomembrane system	IEA	--
GO:0016020	membrane	IEA	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

SIPA1 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR001478 PDZ

IPR000331 Rap_GAP_dom

Graphical View of Domain Structure for InterPro Entry Q96FS4

ProtoNet protein and cluster: Q96FS4

2 Blocks protein domains:

IPB000331 Rap/ran-GAP

IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 Rap-GAP domain

SIPA1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIPA1_HUMAN, Q96FS4

Function: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it

to the putatively inactive GDP-bound state

Induction: Repressed by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

Genatlas biochemistry entry for SIPA1:

signal-induced proliferation-associated 1 mitogen,GTPase-activating protein,130kDa,expressed in lymphoid

tissue,localized in the perinuclear membranous region,mouse Spa-1 homolog

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	TAS	9346962
GO:0005515	protein binding	IPI	--
GO:0046582	Rap GTPase activator activity	NAS	9346962

SIPA1 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sipa1):

hematopoietic system

immune system

tumorigenesis

SIPA1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Sipa1^tm1Nm for SIPA1

inGenious Targeting Laboratory - Custom generated mouse model solutions for SIPA1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIPA1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIPA1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIPA1

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIPA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SIPA1 About

See pathways by source

SuperPath

Contained pathways About

Immune System

Immune System

0.56

Adaptive Immune System

0.56

G-protein signaling Rap1A regulation pathway

G-protein signaling Rap1A regulation pathway

0.88

G-protein signaling Ras family GTPases in kinase cascades (scheme)

MAPK Cascade

0.44

Leukocyte transendothelial migration

Leukocyte transendothelial migration

Rap1 signalling

Rap1 signalling

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for SIPA1

G-protein signaling Rap1A regulation pathway

1 GeneGo (Thomson Reuters) Pathway for SIPA1

G-protein signaling Rap1A regulation pathway

1 BioSystems Pathway for SIPA1

MAPK Cascade

3 Reactome Pathways for SIPA1

	Adaptive Immune System
	Immune System
	Rap1 signalling

1 Kegg Pathway (Kegg details for SIPA1):

Leukocyte transendothelial migration

SIPA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIPA1

4 Interacting proteins for SIPA1 (Q96FS4^{1, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RFWD2	Q8NHY2³	I2D: score=2
AQP2	P41181³	I2D: score=1
BRD4	O60885³	I2D: score=1
CDKN1A	P38936¹	EBI-1054981,EBI-375077

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007010	cytoskeleton organization	NAS	12059963
GO:0007162	negative regulation of cell adhesion	NAS	10373454
GO:0007165	signal transduction	TAS	9346962
GO:0008283	cell proliferation	TAS	9346962
GO:0030308	negative regulation of cell growth	NAS	9183624

SIPA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIPA1

Search CenterWatch for drugs/clinical trials and news about SIPA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIPA1 gene (2 alternative transcripts):

NM_006747.3 NM_153253.29

Unigene Cluster for SIPA1:

Signal-induced proliferation-associated 1

Hs.530477 [show with all ESTs]

Unigene Representative Sequence: AB005666

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534313(uc001ofb.2) ENST00000533361 ENST00000526137 ENST00000527525(uc010rom.1)

ENST00000394224(uc001ofd.2) ENST00000534406 ENST00000530226 ENST00000531339

ENST00000529725 ENST00000528699 ENST00000394227

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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate SIPA1 (see all 10):
		hsa-miR-4324 hsa-miR-34c-5p hsa-miR-520d-5p hsa-miR-449b hsa-miR-486-3p hsa-miR-449a hsa-miR-544b hsa-miR-34a

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Additional mRNA sequence:

AB005666.1 AK303551.1 AK308234.1 AK310068.1 BC010492.1 BC110353.1

10 DOTS entries:

DT.113154 DT.100754646 DT.120707342 DT.120707318 DT.100686956 DT.100754645 DT.113155 DT.86839404

DT.86841102 DT.95357235

24/137 AceView cDNA sequences (see all 137):

BM971645 CA307167 BG756347 AI077341 AA064697 BX097170 T17351 AL042880

AI799994 BM725301 BM973993 BC010492 BM677738 AW576475 NM_006747 BE780730

BG686433 NM_153253 BQ677201 AL583189 BM755975 CF529372 AW838576 AL561454

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIPA1 expression in normal human tissues (normalized intensities) SIPA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTCAGGAAGC

About this image

SIPA1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Heart (Cardiovascular System)
Primitive Heart Tube Cells Primitive Heart Tube

See SIPA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIPA1

SOURCE GeneReport for Unigene cluster: Hs.530477

UniProtKB/Swiss-Prot: SIPA1_HUMAN, Q96FS4

Tissue specificity: Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues

such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal

cord

SABiosciences Expression via Pathway-Focused PCR Array including SIPA1:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SIPA1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sipa1^{1 , 5}	signal-induced proliferation associated gene 1^{1, 5}	84.94(n)¹ 90.27(a)¹		19 (4.34 cM)⁵ 20469¹ NM_001164480.1¹ NP_001157952.1¹ 5651185⁵
lizard (Anolis carolinensis)	Reptilia	SIPA1⁶	Uncharacterized protein	49(a)	1 ↔ 1	GL344427.1(11278-31103)
zebrafish (Danio rerio)	Actinopterygii	SIPA1⁶	signal-induced proliferation-associated 1	38(a)	1 ↔ 1	7(75563725-75616266)

ENSEMBL Gene Tree for SIPA1 (if available)
TreeFam Gene Tree for SIPA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIPA1 gene

SIPA1L1² SIPA1L3² RAP1GAP² SIPA1L2² RAP1GAP2² GARNL3²

3 SIMAP similar genes for SIPA1 using alignment to 3 protein entries: SIPA1_HUMAN (see all proteins):

SIPA1L2 SIPA1L3 SIPA1L1

SIPA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200486439^1,2	C	--	61730588(+)	`CAGCCA/GTGTCC`	1	--	us2k¹		0	--	--	--	--
rs7114037^1,2	C,F	--	61730633(+)	`CTTCAC/AAAGGG`	1	--	us2k¹		4		NA NS	198
rs61732727^1,2	C,F	--	61730648(+)	`GGCGCC/TGGCTG`	1	--	us2k¹		3		NS WA	194
rs199551725^1,2	C	--	61730667(+)	`GCGGGA/GANNNN`	1	--	us2k¹		0	--	--	--	--
rs201933055^1,2	C	--	61730840(+)	`CTCCTA/GCAGGC`	1	--	us2k¹		1		EU	485
rs201418996^1,2	C	--	61730951(+)	`CCCCTC/TGGCTC`	1	--	us2k¹		0	--	--	--	--
rs77200859^1,2	C,F	--	61731000(+)	`TCCCCG/AGACCT`	1	--	us2k¹		1		EA	120
rs200436875^1,2	C	--	61731069(+)	`GGGGGC/GCCGGA`	1	--	us2k¹		0	--	--	--	--
rs144082298^1,2	C	--	61731158(+)	`TGTGGA/GAGGGT`	1	--	us2k¹		0	--	--	--	--
rs186802978^1,2	C	--	61731204(+)	`ACCTCG/TCCCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIPA1 (65405568 - 65418401 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/13 variations for SIPA1 (see all 13): About this table

Variant ID	Type	Subtype	PubMed ID
nsv897723	CNV	Loss	21882294
nsv897754	CNV	Loss	21882294
nsv897748	CNV	Loss	21882294
dgv1175n71	CNV	Loss	21882294
dgv1180n71	CNV	Loss	21882294
nsv897736	CNV	Loss	21882294
dgv1176n71	CNV	Loss	21882294
dgv1183n71	CNV	Loss	21882294
dgv1179n71	CNV	Loss	21882294
dgv1184n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): SIPA1

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing SIPA1

DNA2.0 Custom Variant and Variant Library Synthesis for SIPA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 602180 OMIM disorders: --

9 diseases for SIPA1: About MalaCards

juvenile myelomonocytic leukemia cervical cancer t-cell leukemia cervicitis

leukemia myeloid leukemia thyroiditis breast cancer

colorectal cancer

SIPA1 for disorders About GeneDecksing

3 Novoseek inferred disease relationships for SIPA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloproliferative disorders	46.6	2	17047059 (1), 15310461 (1)
myeloid leukemia chronic	43	2	17047059 (1), 15310461 (1)
tumors	0	2	14660640 (1), 12892713 (1)

Genetic Association Database (GAD): SIPA1
Human Genome Epidemiology (HuGE) Navigator: SIPA1 (12 documents)

Export disorders for SIPA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SIPA1 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with SIPA1)

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Polymorphisms of the SIPA1 gene and sporadic breast c ancer susceptibility. (PubMed id 19765277)^{1, 4, 9} Hsieh S.M....Griffiths L.R. (2009)
Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. (PubMed id 9346962)^{1, 2, 9} Kurachi H.... Minato N. (1997)
Genomic organization and cloning of the human homologue of murine Sipa-1. (PubMed id 9651531)^{1, 2, 9} Ebrahimi S....Sawicki M.P. (1998)
Polymorphisms in MMP9 and SIPA1 are associated with i ncreased risk of nodal metastases in early-stage cervical cancer. (PubMed id 19906411)^{1, 4} Brooks R....Rader J.S. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (2010)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (2009)
Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis. (PubMed id 19089925)^{1, 4} Gaudet M.M....Garcia-Closas M. (2009)
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)^{1, 4} Mavaddat N....Pharoah P.D. (2009)
Distinct inherited metastasis susceptibility exists f or different breast cancer subtypes: a prognosis study. (PubMed id 19825179)^{1, 4} Hsieh S.M....Hunter K.W. (2009)
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. (PubMed id 16563182)^{1, 4} Crawford N.P....Hunter K.W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6494	HGNC: 10885	AceView: SIPA1	Ensembl:ENSG00000213445	euGenes: HUgn6494
ECgene: SIPA1	Kegg: 6494	H-InvDB: SIPA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SIPA1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SIPA1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SIPA1 gene
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Patent Information for SIPA1 gene:
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Signal-Induced Proliferation-Associated 1

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