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SIN3B Gene

protein-coding   GIFtS: 58
GCID: GC19P016940

SIN3 Transcription Regulator Family Member B

(Previous names: SIN3 homolog B, transcription regulator (yeast), SIN3 transcription...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SIN3 Transcription Regulator Family Member B1 2     SIN3 Transcription Regulator Homolog B (Yeast)1
Histone Deacetylase Complex Subunit Sin3b2 3     Paired Amphipathic Helix Protein Sin3b2
Transcriptional Corepressor Sin3b2 3     SIN3 Homolog B, Transcription Regulator2
KIAA07003 5     SIN3 Homolog B, Transcriptional Regulator2
SIN3 Homolog B, Transcription Regulator (Yeast)1     SIN3 Transcription Regulator Homolog B2

External Ids:    HGNC: 193541   Entrez Gene: 233092   Ensembl: ENSG000001275117   OMIM: 6077775   UniProtKB: O751823   

Export aliases for SIN3B gene to outside databases

Previous GC identifers: GC19P017434 GC19P017332 GC19P016785 GC19P016801 GC19P016509


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIN3B Gene:
SIN3B (SIN3 transcription regulator family member B) is a protein-coding gene. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SIN3A.

UniProtKB/Swiss-Prot: SIN3B_HUMAN, O75182
Function: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize
MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses
transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By
similarity)

Gene Wiki entry for SIN3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIN3B gene promoter:
         ER-alpha   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIN3B promoter sequence
   Search Chromatin IP Primers for SIN3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIN3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

SIN3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIN3B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016940:  view genomic region     (about GC identifiers)

Start:
16,940,211 bp from pter      End:
16,991,164 bp from pter
Size:
50,954 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIN3B_HUMAN, O75182 (See protein sequence)
Recommended Name: Paired amphipathic helix protein Sin3b  
Size: 1162 amino acids; 133066 Da
Subunit: Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with
HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with RNF220
(By similarity). Interacts with HCFC1
Sequence caution: Sequence=BAA31675.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q2NL91 Q68GC2 Q6P4B8 Q8TB34 Q9BSC8
Alternative splicing: 3 isoforms:  O75182-1   O75182-2   O75182-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIN3B: NX_O75182

Explore proteomics data for SIN3B at MOPED

Post-translational modifications: 

  • Ubiquitinated by RNF220 that leads to proteasomal degradation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIN3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056075.1  
    ENSEMBL proteins: 
     ENSP00000248054   ENSP00000473039   ENSP00000369131   ENSP00000472365   ENSP00000469740  
    Reactome Protein details: O75182

    SIN3B Human Recombinant Protein Products:

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    Novus Biologicals SIN3B Proteins
    Novus Biologicals SIN3B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIN3B

     
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    antibodies-online proteins for SIN3B (4 products) 

     
    antibodies-online peptides for SIN3B

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    antibodies-online antibodies for SIN3B (36 products) 

    SIN3B Assay Products:

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    Cloud-Clone Corp. CLIAs for SIN3B
    Search eBioscience for ELISAs for SIN3B 
    antibodies-online kits for SIN3B (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013194 HDAC_interact
     IPR003822 PAH

    Graphical View of Domain Structure for InterPro Entry O75182

    ProtoNet protein and cluster: O75182

    1 Blocks protein domain: IPB003822 Paired amphipathic helix

    UniProtKB/Swiss-Prot: SIN3B_HUMAN, O75182
    Similarity: Contains 3 PAH (paired amphipathic helix) domains


    Find genes that share domains with SIN3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIN3B_HUMAN, O75182
    Function: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize
    MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses
    transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI12670868
         
    Find genes that share ontologies with SIN3B           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sin3b):
     cellular  growth/size/body  hematopoietic system  immune system  liver/biliary system 
     mortality/aging  no phenotypic analysis  normal  skeleton 

    Find genes that share phenotypes with SIN3B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sin3btm1.2Rdp for SIN3B

       genOway: Develop your customized and physiologically relevant rodent model for SIN3B

    miRNA
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    miRTarBase miRNAs that target SIN3B:
    hsa-mir-335-5p (MIRT019064), hsa-mir-186-5p (MIRT045249), hsa-mir-92a-3p (MIRT049321)

    Block miRNA regulation of human, mouse, rat SIN3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIN3B (see all 17):
    hsa-miR-16-2* hsa-miR-181c hsa-miR-1271 hsa-miR-1323 hsa-miR-3121-3p hsa-miR-96 hsa-miR-181b hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidSIN3B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIN3B
    Predesigned siRNA for gene silencing in human, mouse, rat SIN3B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SIN3B (NM_015260)
    Sino Biological Human cDNA Clone for SIN3B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIN3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIN3B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIN3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIN3B_HUMAN, O75182: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000805X chromosome IEA--
    GO:0000806Y chromosome IEA--
    GO:0001741XY body IEA--
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with SIN3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIN3B About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3GPCR Pathway
    Estrogen Pathway0.55
    4Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43


    Find genes that share SuperPaths with SIN3B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIN3B (see all 6)
        SMAD Signaling Network
    Nur77 Signaling in T-Cell
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for SIN3B
        Transcription Sin3 and NuRD in transcription regulation

    4 BioSystems Pathways for SIN3B
        Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by HDAC Class I
    Regulation of Telomerase
    Hedgehog signaling events mediated by Gli proteins


    1 Reactome Pathway for SIN3B
        NoRC negatively regulates rRNA expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIN3B
    Interactions:

        Search GeneGlobe Interaction Network for SIN3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIN3B (O751823 ENSP000003691314) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166373, ENSP000003700834I2D: score=1 STRING: ENSP00000370083
    HDAC1Q135473, ENSP000003626494I2D: score=5 STRING: ENSP00000362649
    HCFC1P516103, ENSP000003095554I2D: score=3 STRING: ENSP00000309555
    HDAC2Q927693, ENSP000003813314I2D: score=3 STRING: ENSP00000381331
    MXI1P505393, ENSP000003311524I2D: score=3 STRING: ENSP00000331152
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007519skeletal muscle tissue development IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with SIN3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIN3B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIN3B gene: 
    NM_015260.2  

    Unigene Cluster for SIN3B:

    SIN3 transcription regulator homolog B (yeast)
    Hs.13999  [show with all ESTs]
    Unigene Representative Sequence: NM_015260
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248054(uc002new.3 uc002nez.2 uc010xpi.1 uc010eaj.1)
    ENST00000596802 ENST00000379803(uc002ney.2) ENST00000596638 ENST00000599880
    ENST00000595541 ENST00000594372 ENST00000595900 ENST00000602204 ENST00000595049
    ENST00000601141 ENST00000594235
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SIN3B (see all 17):
    hsa-miR-16-2* hsa-miR-181c hsa-miR-1271 hsa-miR-1323 hsa-miR-3121-3p hsa-miR-96 hsa-miR-181b hsa-miR-548o
    SwitchGear 3'UTR luciferase reporter plasmidSIN3B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: SIN3B (NM_015260)
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      QuantiTect SYBR Green Assays in human, mouse, rat SIN3B
      QuantiFast Probe-based Assays in human, mouse, rat SIN3B

    Additional mRNA sequence: 

    AB014600.2 AK001633.1 AK295618.1 AK311023.1 AY706204.1 BC005113.1 BC025026.1 BC063531.1 
    BC110821.1 

    15 DOTS entries:

    DT.101971559  DT.97846923  DT.86850679  DT.100780899  DT.100780900  DT.95176338  DT.40198171  DT.91808304 
    DT.91832363  DT.100027753  DT.121503540  DT.121503547  DT.91742838  DT.95273757  DT.97790900 

    Selected AceView cDNA sequences (see all 269):

    AW170124 BU754049 AW025678 BE677785 BI916555 AI017713 BM449771 AI571992 
    BM473667 NM_015260 AA347195 AL119569 AY706204 BE379141 BM543227 BU899250 
    AA741491 BI255128 CR619281 AW136758 AA324007 BU151311 BI850724 CR597022 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIN3B (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
    SP1:                          -     -                             -                 -     -                                                           -     -   
    SP2:                          -     -                             -           -     -     -                                                           -     -   
    SP3:                          -     -                                                                                                                           
    SP4:                          -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c · 25d
    SP1:  -                 -     -                                       
    SP2:  -                 -     -                                       
    SP3:                                                                  
    SP4:                                                                  
    SP5:                    -     -                                       


    ECgene alternative splicing isoforms for SIN3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIN3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTAGGGA
    SIN3B Expression
    About this image

    SIN3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIN3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13999
        Custom PCR Arrays for SIN3B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIN3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SIN3B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sin3b1 , 5 transcriptional regulator, SIN3B (yeast)1, 5 85.37(n)1
    92.51(a)1
      8 (35.08 cM)5
    204671  NM_009188.41  NP_033214.21 
     727232885 
    chicken
    (Gallus gallus)
    Aves SIN3B1 SIN3 transcription regulator homolog B (yeast) 77.79(n)
    88.45(a)
      420140  XM_418257.4  XP_418257.4 
    lizard
    (Anolis carolinensis)
    Reptilia SIN3B6
    SIN3 transcription regulator family member B
    78(a)
    1 ↔ 1
    AAWZ02038459(648-9596)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL848183.22   -- 78.86(n)    AL848183.2 
    zebrafish
    (Danio rerio)
    Actinopterygii 570438362   -- 75.83(n)    57043836 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sin3A6
    Sin3A
    19(a)
    1 → many
    2R(8462745-8480397)
    worm
    (Caenorhabditis elegans)
    Secernentea sin-36
    Protein SIN-3, isoform b (sin-3) mRNA, complete cd...
    12(a)
    1 → many
    I(8416832-8425042) WBGene00004117
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIN36
    Component of the Sin3p-Rpd3p histone deacetylase c...
    15(a)
    1 → many
    XV(316938-321548) YOL004W


    ENSEMBL Gene Tree for SIN3B (if available)
    TreeFam Gene Tree for SIN3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIN3B gene
    SIN3A2  
    1 SIMAP similar gene for SIN3B using alignment to 3 protein entries:     SIN3B_HUMAN (see all proteins):
    SIN3A

    Find genes that share paralogs with SIN3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIN3B (see all 1273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420849431,2
    --16938229(+) ACAAAA/CCAAAT 1 -- us2k10--------
    rs757896531,2
    F--16938277(+) ACTGGG/AAACAC 1 -- us2k11Minor allele frequency- A:0.16WA 118
    rs1119374271,2
    C,F--16938311(+) GGCTGC/TGTTTA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1826583101,2
    --16938375(+) CAAAGC/GAAATG 1 -- us2k10--------
    rs7738661,2
    C,F--16938417(-) GACCAG/ACCTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1995608461,2
    C--16938607(+) TTTCT-/TTTTTT 1 -- us2k10--------
    rs1147490891,2
    C,F--16938627(+) AGAGAT/CGAGAT 1 -- us2k12Minor allele frequency- C:0.19WA NA 238
    rs1869360481,2
    --16938648(+) AAAAAA/GAAAAA 1 -- us2k10--------
    rs1391549421,2
    --16938682(+) AGGCTA/GGGGTG 1 -- us2k10--------
    rs1148604891,2
    F--16938721(+) GCCTTG/AAACTC 1 -- us2k11Minor allele frequency- A:0.09WA 118

    HapMap Linkage Disequilibrium report for SIN3B (16940211 - 16991164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SIN3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718268CNV Deletion23290073
    esv1088392CNV Deletion17803354
    esv2718269CNV Deletion23290073
    esv2718267CNV Deletion23290073
    esv24348CNV Loss19812545
    nsv911169CNV Loss21882294
    nsv911168CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIN3B
    DNA2.0 Custom Variant and Variant Library Synthesis for SIN3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607777    OMIM disorders: --


    Find genes that share disorders with SIN3B           About GenesLikeMe

    Genetic Association Database (GAD): SIN3B
    Human Genome Epidemiology (HuGE) Navigator: SIN3B (3 documents)

    Export disorders for SIN3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIN3B gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with SIN3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2 Wysocka J.... Herr W. (Genes Dev. 2003)
    5. The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. (PubMed id 18205948)1, 9 Dhanda R.S....Olsson I. (BMC Mol. Biol. 2008)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Detailed structural-functional analysis of the KrA1ppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. (PubMed id 22203677)1 Daftary G.S....Urrutia R. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23309 HGNC: 19354 AceView: SIN3B Ensembl:ENSG00000127511 euGenes: HUgn23309
    ECgene: SIN3B H-InvDB: SIN3B

    (According to HUGE)
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    HUGE: KIAA0700

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIN3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIN3B gene:
    Search GeneIP for patents involving SIN3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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