Aliases for SIN3B Gene
External Ids for SIN3B Gene
Previous GeneCards Identifiers for SIN3B Gene
GeneCards Summary for SIN3B Gene
SIN3B (SIN3 Transcription Regulator Family Member B) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is SIN3A.
UniProtKB/Swiss-Prot for SIN3B Gene
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).