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Aliases for SIN3A Gene

Aliases for SIN3A Gene

  • SIN3 Transcription Regulator Family Member A 2 3 5
  • SIN3 Homolog A, Transcription Regulator (Yeast) 2
  • SIN3 Transcription Regulator Homolog A (Yeast) 2
  • Histone Deacetylase Complex Subunit Sin3a 4
  • Transcriptional Corepressor Sin3a 4

External Ids for SIN3A Gene

Previous GeneCards Identifiers for SIN3A Gene

  • GC15M071541
  • GC15M068754
  • GC15M073239
  • GC15M073379
  • GC15M073450
  • GC15M075661
  • GC15M052420

Summaries for SIN3A Gene

Entrez Gene Summary for SIN3A Gene

  • The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIN3A Gene

SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Diseases associated with SIN3A include Chromosome 15Q24 Deletion Syndrome. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Macrophage Differentiation and Growth Inhibition by METS. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is SIN3B.

UniProtKB/Swiss-Prot for SIN3A Gene

  • Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.

Gene Wiki entry for SIN3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3A Gene

Genomics for SIN3A Gene

Regulatory Elements for SIN3A Gene

Enhancers for SIN3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIN3A on UCSC Golden Path with GeneCards custom track

Genomic Location for SIN3A Gene

Chromosome:
15
Start:
75,369,379 bp from pter
End:
75,455,842 bp from pter
Size:
86,464 bases
Orientation:
Minus strand

Genomic View for SIN3A Gene

Genes around SIN3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIN3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIN3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIN3A Gene

Proteins for SIN3A Gene

  • Protein details for SIN3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST3-SIN3A_HUMAN
    Recommended name:
    Paired amphipathic helix protein Sin3a
    Protein Accession:
    Q96ST3
    Secondary Accessions:
    • B2RNS5
    • Q8N8N4
    • Q8NC83
    • Q8WV18
    • Q96L98
    • Q9UFQ1

    Protein attributes for SIN3A Gene

    Size:
    1273 amino acids
    Molecular mass:
    145175 Da
    Quaternary structure:
    • Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11 (By similarity). Interacts with PPHLN1 (PubMed:17963697). Found in a complex with YY1, GON4L and HDAC1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SIN3A Gene

neXtProt entry for SIN3A Gene

Proteomics data for SIN3A Gene at MOPED

Post-translational modifications for SIN3A Gene

  • SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
  • Ubiquitination at Lys 343, Lys 727, and Lys 747
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIN3A (SIN3A)

No data available for DME Specific Peptides for SIN3A Gene

Domains & Families for SIN3A Gene

Gene Families for SIN3A Gene

Protein Domains for SIN3A Gene

Suggested Antigen Peptide Sequences for SIN3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ST3

UniProtKB/Swiss-Prot:

SIN3A_HUMAN :
  • Contains 3 PAH (paired amphipathic helix) domains.
Domain:
  • Contains 3 PAH (paired amphipathic helix) domains.
genes like me logo Genes that share domains with SIN3A: view

Function for SIN3A Gene

Molecular function for SIN3A Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.

Gene Ontology (GO) - Molecular Function for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 10049357
genes like me logo Genes that share ontologies with SIN3A: view
genes like me logo Genes that share phenotypes with SIN3A: view

Animal Models for SIN3A Gene

MGI Knock Outs for SIN3A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIN3A Gene

Localization for SIN3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIN3A Gene

Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIN3A Gene COMPARTMENTS Subcellular localization image for SIN3A gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SIN3A Gene

Pathways & Interactions for SIN3A Gene

genes like me logo Genes that share pathways with SIN3A: view

Gene Ontology (GO) - Biological Process for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007568 aging IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SIN3A: view

No data available for SIGNOR curated interactions for SIN3A Gene

Drugs & Compounds for SIN3A Gene

No Compound Related Data Available

Transcripts for SIN3A Gene

Unigene Clusters for SIN3A Gene

SIN3 transcription regulator homolog A (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIN3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - -
SP11:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SIN3A Gene

GeneLoc Exon Structure for
SIN3A
ECgene alternative splicing isoforms for
SIN3A

Expression for SIN3A Gene

mRNA expression in normal human tissues for SIN3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIN3A Gene

This gene is overexpressed in Lymph node (15.3) and Peripheral blood mononuclear cells (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIN3A Gene



SOURCE GeneReport for Unigene cluster for SIN3A Gene Hs.513039

genes like me logo Genes that share expression patterns with SIN3A: view

Protein tissue co-expression partners for SIN3A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIN3A Gene

Orthologs for SIN3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIN3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIN3A 35
  • 93.43 (n)
  • 98.82 (a)
SIN3A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIN3A 35
  • 93.11 (n)
  • 98.9 (a)
SIN3A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sin3a 35
  • 90.91 (n)
  • 98.11 (a)
Sin3a 16
Sin3a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIN3A 35
  • 99.74 (n)
  • 99.92 (a)
SIN3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sin3a 35
  • 90.25 (n)
  • 98.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SIN3A 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIN3A 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIN3A 35
  • 81.95 (n)
  • 94.16 (a)
SIN3A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIN3A 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sin3a 35
  • 74.08 (n)
  • 82.82 (a)
Str.14936 35
African clawed frog
(Xenopus laevis)
Amphibia Sin3 35
zebrafish
(Danio rerio)
Actinopterygii wufb95g11 35
sin3aa 36
  • 77 (a)
OneToMany
sin3ab 36
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007892 35
  • 58.26 (n)
  • 58.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sin3A 35
  • 58.9 (n)
  • 60.59 (a)
Sin3A 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sin-3 36
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIN3 36
  • 18 (a)
OneToMany
SIN3 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4585 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3742 36
  • 39 (a)
OneToMany
Species with no ortholog for SIN3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIN3A Gene

ENSEMBL:
Gene Tree for SIN3A (if available)
TreeFam:
Gene Tree for SIN3A (if available)

Paralogs for SIN3A Gene

Paralogs for SIN3A Gene

(1) SIMAP similar genes for SIN3A Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SIN3A: view

Variants for SIN3A Gene

Sequence variations from dbSNP and Humsavar for SIN3A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs60213317 - 75,375,790(+) CTCCA(A/T)GGTCT reference, missense
rs4993929 -- 75,440,221(+) aagaa(C/T)gtaag intron-variant
rs5813801 -- 75,437,177(+) TTTTT(-/T)GCAAT intron-variant
rs6495171 -- 75,373,282(+) ctgag(A/G)caaga intron-variant
rs6495172 -- 75,398,436(+) tttgg(A/G)aggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIN3A Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073
nsv1615 CNV Insertion 18451855
nsv904386 CNV Gain 21882294
nsv525265 CNV Gain 19592680
nsv904387 CNV Gain 21882294
esv2749895 CNV Deletion 23290073
dgv2414n71 CNV Loss 21882294
nsv827389 CNV Gain 20364138

Variation tolerance for SIN3A Gene

Residual Variation Intolerance Score: 1.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIN3A Gene

Human Gene Mutation Database (HGMD)
SIN3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3A Gene

Disorders for SIN3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIN3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SIN3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIN3A

Genetic Association Database (GAD)
SIN3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIN3A
genes like me logo Genes that share disorders with SIN3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIN3A Gene

Publications for SIN3A Gene

  1. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PMID: 11259580) Mathur M. … Samuels H.H. (Mol. Cell. Biol. 2001) 3 4 23 67
  2. Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. (PMID: 18535655) Burgio G. … Corona D.F. (PLoS Genet. 2008) 3 23
  3. Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. (PMID: 17210713) Farhana L. … Fontana J.A. (Cancer Res. 2007) 3 23
  4. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. (PMID: 18059533) Sekhavat A. … Davie J.R. (Biochem. Cell Biol. 2007) 3 23
  5. Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. (PMID: 14612411) Kim D.W. … Lassar A.B. (Mol. Cell. Biol. 2003) 3 23

Products for SIN3A Gene

Sources for SIN3A Gene

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