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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIN3A Gene

protein-coding GIFtS: 63
GCID: GC15M075661

SIN3 transcription regulator homolog A (yeast)

(Previous names: SIN3 homolog A, transcription regulator (yeast) )

Explore 17 diseases affiliated with
SIN3A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SIN3 Transcription Regulator Homolog A (Yeast)¹ ²		SIN3 Homolog A, Transcription Regulator (Yeast)¹
Histone Deacetylase Complex Subunit Sin3a² ³		Paired Amphipathic Helix Protein Sin3a²
Transcriptional Corepressor Sin3a² ³		SIN3 Homolog A, Transcription Regulator²
DKFZP434K2235¹		Transcriptional Co-Repressor Sin3A²
KIAA0700¹		Transcriptional Regulator, SIN3A²

External Ids:	HGNC: 19353¹	Entrez Gene: 25942²	Ensembl: ENSG00000169375⁷	OMIM: 607776⁵	UniProtKB: Q96ST3³

Export aliases for SIN3A gene to outside databases

Previous GC identifers: GC15M071541 GC15M068754 GC15M073239 GC15M073379 GC15M073450 GC15M052420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIN3A:

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH)

domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3

Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive

genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by

tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone

deacetylation

Gene Wiki entry for SIN3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIN3A gene promoter:
NRF-2 Ik-2 HFH-1 Sox9
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIN3A promoter sequence

Search SABiosciences Chromatin IP Primers for SIN3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIN3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q22.33

SIN3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIN3A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M075661: view genomic region (about GC identifiers)

Start:	75,661,720 bp from pter	End:	75,748,183 bp from pter
Size:	86,464 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3 (See protein sequence)

Recommended Name: Paired amphipathic helix protein Sin3a

Size: 1273 amino acids; 145175 Da

Subunit: Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with

PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (By similarity). Interacts with ARID4B, BRMS1L, DACH1, HCFC1,

HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to

gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel

with histone deacetylase

Subcellular location: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L

1 PDB 3D structure from and Proteopedia for SIN3A:

1PO4 (3D)

Secondary accessions: B2RNS5 Q8N8N4 Q8NC83 Q8WV18 Q96L98 Q9UFQ1

Explore the universe of human proteins at neXtProt for SIN3A: NX_Q96ST3

Post-translational modifications:

SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96ST3

SIN3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001138829.1 NP_001138830.1 NP_056292.1

ENSEMBL proteins:

ENSP00000378402 ENSP00000353622 ENSP00000378403 ENSP00000455204 ENSP00000455072

ENSP00000454750 ENSP00000455834 ENSP00000455662 ENSP00000455644 ENSP00000456997

ENSP00000454296

Reactome Protein details: Q96ST3
Human Recombinant Protein Products for SIN3A:

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	Novus Biologicals SIN3A Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SIN3A

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	IEA	--
GO:0000785	chromatin	--	--
GO:0005634	nucleus	ISS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--

SIN3A for ontologies About GeneDecksing

SIN3A Antibody Products:

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	Uscn Antibodies for SIN3A
	ThermoFisher Antibody for SIN3A

Assay Products for SIN3A:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for SIN3A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SIN3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIN3A for domains About GeneDecksing

2 InterPro domains/families:

IPR013194 HDAC_interact

IPR003822 PAH

Graphical View of Domain Structure for InterPro Entry Q96ST3

ProtoNet protein and cluster: Q96ST3

1 Blocks protein family: IPB003822 Paired amphipathic helix

UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3

Similarity: Contains 3 PAH (paired amphipathic helix) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIN3A_HUMAN, Q96ST3

Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive

genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by

tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone

deacetylation

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001102	RNA polymerase II activating transcription factor binding	IPI	--
GO:0001103	RNA polymerase II repressing transcription factor binding	IEA	--
GO:0001106	RNA polymerase II transcription corepressor activity	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--

SIN3A for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sin3a):

mortality/aging

normal

tumorigenesis

SIN3A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sin3a^tm1.1Rdp for SIN3A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SIN3A

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		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate SIN3A (see all 73):
		hsa-miR-323-3p hsa-miR-576-3p hsa-miR-607 hsa-miR-376b hsa-miR-3146 hsa-miR-146a hsa-miR-3613-3p hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: SIN3A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIN3A (see all 7) OriGene shRNA RFP: SIN3A Browse OriGene siRNA
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SIN3A
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIN3A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Sin3 and NuRD in transcription regulation

Transcription_Sin3 and NuRD in transcription regulation

1.00

Transcription Sin3 and NuRD in transcription regulation

0.96

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

1.00

Fatty acid, triacylglycerol, and ketone body metabolism

0.52

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Signal transduction Activin A signaling regulation

Signal transduction Activin A signaling regulation

1.00

Signal transduction_Activin A signaling regulation

0.96

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for SIN3A

	Immune response Function of MEF2 in T lymphocytes
	Transcription Sin3 and NuRD in transcription regulation
	Signal transduction Activin A signaling regulation
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIN3A (see all 8)

	SMAD Signaling Network
	DNA Methylation and Transcriptional Repression
	Nur77 Signaling in T-Cell
	Protein Acetylation and Deacetylation
	Glucocorticoid Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for SIN3A

Chromatin Regulation / Acetylation

4 GeneGo (Thomson Reuters) Pathways for SIN3A

	Signal transduction Activin A signaling regulation
	Transcription Sin3 and NuRD in transcription regulation
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes
	Immune response Function of MEF2 in T lymphocytes

5/8 BioSystems Pathways for SIN3A (see all 8)

	EGFR1 Signaling Pathway
	Hedgehog Signaling Pathway
	Delta-Notch Signaling Pathway
	C-MYB transcription factor network
	Hedgehog signaling events mediated by Gli proteins

5/6 Reactome Pathways for SIN3A (see all 6)

	Hemostasis
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Factors involved in megakaryocyte development and platelet production
	Metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism

1 Kegg Pathway (Kegg details for SIN3A):

Huntington's disease

SIN3A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIN3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/921 Interacting proteins for SIN3A (Q96ST3^{1, 2, 3} ENSP00000353622⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 921)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=4
HIST1H4B	P62805³	I2D: score=4
HIST1H4C	P62805³	I2D: score=4
HIST1H4D	P62805³	I2D: score=4
HIST1H4E	P62805³	I2D: score=4

About this table

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP	--
GO:0001701	in utero embryonic development	IEA	--
GO:0002218	activation of innate immune response	IMP	--
GO:0002230	positive regulation of defense response to virus by host	IMP	--
GO:0006260	DNA replication	IEA	--

SIN3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIN3A
Search CenterWatch for drugs/clinical trials and news about SIN3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIN3A gene (3 alternative transcripts):

NM_001145357.1 NM_001145358.1 NM_015477.2

Unigene Cluster for SIN3A:

SIN3 transcription regulator homolog A (yeast)

Hs.513039 [show with all ESTs]

Unigene Representative Sequence: NM_001145358

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394947(uc002bai.3 uc002baj.3 uc010uml.2) ENST00000360439

ENST00000394949 ENST00000566640 ENST00000570124 ENST00000570021 ENST00000564778

ENST00000562776 ENST00000568431 ENST00000567289(uc002bak.4) ENST00000570115

ENST00000568309 ENST00000568190 ENST00000568919 ENST00000565264

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SIN3A Browse OriGene MicroRNA Expression Plasmids
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		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate SIN3A (see all 73):
		hsa-miR-323-3p hsa-miR-576-3p hsa-miR-607 hsa-miR-376b hsa-miR-3146 hsa-miR-146a hsa-miR-3613-3p hsa-miR-200b

		SwitchGear 3'UTR luciferase reporter plasmid: SIN3A 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIN3A

Additional cDNA sequence:

AF418569.1 AK027559.1 AK074800.1 AK074903.1 AK096477.1 AL117513.1 AL832463.1 AY044430.1

BC018973.1 BC030563.1 BC041047.1 BC052275.1 BC137098.1 BC137099.1 BX649162.1

18 DOTS entries:

DT.100784834 DT.95114567 DT.121052901 DT.213637 DT.91702664 DT.70102824 DT.91980536 DT.100837241

DT.308404 DT.99994070 DT.100784838 DT.100695916 DT.102839747 DT.121052713 DT.91767879 DT.95249365

DT.95275350 DT.95121958

24/219 AceView cDNA sequences (see all 219):

AI584027 BU179662 BQ689570 BM839505 BQ071885 BU171376 BE672480 AL832463

AA700225 AK096477 BQ637378 BM976762 BQ651199 CD358655 BU196686 BM468239

CK429896 BQ219351 BP364506 CB107976 CN483996 AA357028 AI498259 CA455409

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SIN3A (see all 11) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	·	10d	·	10e	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:					-		-		-		-		-		-								-
SP2:									-		-		-		-								-
SP3:											-		-		-								-
SP4:															-								-
SP5:																							-

ExUns:	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26a	·	26b	^	27
SP1:											-
SP2:											-
SP3:											-
SP4:
SP5:

ECgene alternative splicing isoforms for SIN3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIN3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCACTGCTC

About this image

SIN3A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SIN3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIN3A

SOURCE GeneReport for Unigene cluster: Hs.513039

SABiosciences Expression via Pathway-Focused PCR Array including SIN3A:

Huntington's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIN3A Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIN3A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIN3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SIN3A gene from 9/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SIN3A¹	SIN3 homolog A, transcription regulator (yeast)	82.01(n) 94.19(a)		415307 XM_413695.3 XP_413695.3
lizard (Anolis carolinensis)	Reptilia	SIN3A⁶	--	89(a)	1 ↔ 1	GL343486.1(5967-32760)
African clawed frog (Xenopus laevis)	Amphibia	Sin3²	transcription co-repressor Sin3	77.17(n)		AF154112.1
zebrafish (Danio rerio)	Actinopterygii	wufb95g11²	Transcribed sequence with moderate similarity to protein more	77.09(n)		57048704
fruit fly (Drosophila melanogaster)	Insecta	Sin3A¹	CG8815-PA	51.55(n) 47(a)		36382 NM_001201983.1 NP_001188912.1
worm (Caenorhabditis elegans)	Secernentea	sin-3⁶	SIN3 (yeast Switch INdependent) histone deacetylas...	15(a)	possible ortholog	I(8416826-8425036)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SIN3(YOL004W)⁴ SIN3¹	Component of the Sin3p-Rpd3p histone deacetylase complex, more⁴ Sin3p¹	43.59(n)¹ 31.18(a)¹		15(316938-321548)⁴ 854158^{1, 4} NP_014639.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	SNL1¹	paired amphipathic helix protein Sin3-like 1	47.35(n) 37.02(a)		821265 NM_001202860.1 NP_001189789.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	transcriptional repressor, putative, expressed (see all 3)	23(a) 23(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(38746-47170) 1(512890-521448)

ENSEMBL Gene Tree for SIN3A (if available)
TreeFam Gene Tree for SIN3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SIN3A gene

SIN3B²

1 SIMAP similar gene for SIN3A using alignment to 9 protein entries: SIN3A_HUMAN (see all proteins):

SIN3B

SIN3A for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for SIN3A (see all 6)
PGOHUM00000238711 PGOHUM00000246854 PGOHUM00000246909 PGOHUM00000246924 PGOHUM00000247246

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139541749^1,2	C	other	75705226(+)	`GGTGGA/GAATCT`	6	P S	mis¹		0	--	--	--	--
rs11551122^1,2	C,H	--	75663014(-)	`TTTTTC/TTTATT`	3	--	ut3¹		2		NS NA	182
rs186543338^1,2		--	75663222(+)	`TCCCTA/GCTTCA`	3	--	ut3¹		0	--	--	--	--
rs137986718^1,2		--	75663229(+)	`TTCACA/GGTATT`	3	--	ut3¹		0	--	--	--	--
rs59183656^1,2	C	--	75663305(+)	`TTTAC-/AAAAAA`	3	--	ut3¹		1		NA	2
rs190562920^1,2		--	75663406(+)	`GTCTTA/GTACAT`	3	--	ut3¹		0	--	--	--	--
rs149497862^1,2		--	75663431(+)	`TAAATC/GTGAAG`	3	--	ut3¹		0	--	--	--	--
rs11551123^1,2	C	--	75663441(-)	`AGTACT/CGTGGC`	3	--	ut3¹ ese³		2		NA	4
rs112103821^1,2	C	--	75663521(+)	`AGTATA/GTACAT`	3	--	ut3¹		0	--	--	--	--
rs143718821^1,2	C	--	75663552(+)	`AAAAT-/TGTGTGT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIN3A (75661720 - 75748183 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIN3A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIN3A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIN3A for disorders           About GeneDecksing

OMIM gene information: 607776    OMIM disorders: --

17 diseases for SIN3A:    About MalaCards

intestinal atresia acute promyelocytic leukemia synovial sarcoma acute myeloid leukemia

burkitt's lymphoma myeloid leukemia myeloid malignancy dermatomyositis

huntington's disease conjunctivitis sarcoma leukemia

retinoblastoma lung cancer breast cancer thyroiditis

neuronitis

1 disease from the University of Copenhagen DISEASES database for SIN3A:

Rett syndrome

Export disorders for SIN3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SIN3A gene, integrated from 9 sources (see all 241):
(articles sorted by number of sources associating them with SIN3A)

Utopia: connect your pdf to the dynamic
world of online information

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PubMed id 11259580)^{1, 2, 9} Mathur M.... Samuels H.H. (2001)
TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. (PubMed id 17803295)^{1, 2} Pungaliya P....Rubin E.H. (2007)
SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. (PubMed id 16820529)^{1, 2} Viiri K.M.... Lohi O. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PubMed id 15451426)^{1, 2} Nikolaev A.Y.... Gu W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)^{1, 2} Wu K.... Pestell R.G. (2003)
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)^{1, 2} Wysocka J.... Herr W. (2003)
Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)^{1, 2} Fleischer T.C....Ayer D.E. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25942	HGNC: 19353	AceView: SIN3A	Ensembl:ENSG00000169375	euGenes: HUgn25942
ECgene: SIN3A	Kegg: 25942	H-InvDB: SIN3A

(According to HUGE)
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HUGE: KIAA0700

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIN3A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SIN3A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SIN3A gene
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Patent Information for SIN3A gene:
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GeneCards and IP:
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SIN3 transcription regulator homolog A (yeast)

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SIN3 transcription regulator homolog A (yeast)

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