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SIN3A Gene

protein-coding   GIFtS: 64
GCID: GC15M075661

SIN3 Transcription Regulator Family Member A

(Previous names: SIN3 homolog A, transcription regulator (yeast), SIN3 transcription...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SIN3 Transcription Regulator Family Member A1 2     Paired Amphipathic Helix Protein Sin3a2
Histone Deacetylase Complex Subunit Sin3a2 3     SIN3 Homolog A, Transcription Regulator2
Transcriptional Corepressor Sin3a2 3     SIN3 Transcription Regulator Homolog A2
SIN3 Homolog A, Transcription Regulator (Yeast)1     Transcriptional Co-Repressor Sin3A2
SIN3 Transcription Regulator Homolog A (Yeast)1     Transcriptional Regulator, SIN3A2

External Ids:    HGNC: 193531   Entrez Gene: 259422   Ensembl: ENSG000001693757   OMIM: 6077765   UniProtKB: Q96ST33   

Export aliases for SIN3A gene to outside databases

Previous GC identifers: GC15M071541 GC15M068754 GC15M073239 GC15M073379 GC15M073450 GC15M052420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIN3A Gene:
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix
(PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max
complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIN3A Gene:
SIN3A (SIN3 transcription regulator family member A) is a protein-coding gene. Diseases associated with SIN3A include rett syndrome, and synovial sarcoma. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SIN3B.

UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3
Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive
genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription
by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with
histone deacetylation

Gene Wiki entry for SIN3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIN3A gene promoter:
         NRF-2   Ik-2   HFH-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIN3A promoter sequence
   Search Chromatin IP Primers for SIN3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIN3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q22.33

SIN3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIN3A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075661:  view genomic region     (about GC identifiers)

Start:
75,661,720 bp from pter      End:
75,748,183 bp from pter
Size:
86,464 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3 (See protein sequence)
Recommended Name: Paired amphipathic helix protein Sin3a  
Size: 1273 amino acids; 145175 Da
Subunit: Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with
PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (By similarity). Interacts with ARID4B, BRMS1L, DACH1,
HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits
SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression
in parallel with histone deacetylase
1 PDB 3D structure from and Proteopedia for SIN3A:
1PO4 (3D)    
Secondary accessions: B2RNS5 Q8N8N4 Q8NC83 Q8WV18 Q96L98 Q9UFQ1

Explore the universe of human proteins at neXtProt for SIN3A: NX_Q96ST3

Explore proteomics data for SIN3A at MOPED

Post-translational modifications: 

  • SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP21
  • Ubiquitination2 at Lys343, Lys727, Lys747
  • Modification sites at PhosphoSitePlus

  • See SIN3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138829.1  NP_001138830.1  NP_056292.1  

    ENSEMBL proteins: 
     ENSP00000378402   ENSP00000353622   ENSP00000378403   ENSP00000455204   ENSP00000455072  
     ENSP00000454750   ENSP00000455834   ENSP00000455662   ENSP00000455644   ENSP00000456997  
     ENSP00000454296  
    Reactome Protein details: Q96ST3

    SIN3A Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for SIN3A
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    Novus Biologicals SIN3A Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIN3A

    SIN3A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIN3A
    R&D Systems Antibodies for SIN3A
    Cell Signaling Technology (CST) Antibodies for SIN3A 
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    Novus Biologicals SIN3A Antibodies
    Search for Antibodies for SIN3A at Abcam
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    ThermoFisher Antibody for SIN3A
    LSBio Antibodies in human, mouse, rat for SIN3A

    SIN3A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SIN3A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIN3A
    Cloud-Clone Corp. CLIAs for SIN3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013194 HDAC_interact
     IPR003822 PAH

    Graphical View of Domain Structure for InterPro Entry Q96ST3

    ProtoNet protein and cluster: Q96ST3

    1 Blocks protein domain: IPB003822 Paired amphipathic helix

    UniProtKB/Swiss-Prot: SIN3A_HUMAN, Q96ST3
    Similarity: Contains 3 PAH (paired amphipathic helix) domains


    SIN3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIN3A_HUMAN, Q96ST3
    Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive
    genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription
    by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with
    histone deacetylation

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001102RNA polymerase II activating transcription factor binding IPI--
    GO:0001103RNA polymerase II repressing transcription factor binding IEA--
    GO:0001106RNA polymerase II transcription corepressor activity IEA--
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
         
    SIN3A for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sin3a):
     mortality/aging  normal  tumorigenesis 

    SIN3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sin3atm1.1Rdp for SIN3A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIN3A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIN3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIN3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIN3A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SIN3A:
    hsa-mir-1 (MIRT023524), hsa-mir-155-5p (MIRT020539), hsa-mir-92a-3p (MIRT049314), hsa-mir-92b-3p (MIRT040584), hsa-mir-93-3p (MIRT038894), hsa-mir-455-3p (MIRT037870)

    Block miRNA regulation of human, mouse, rat SIN3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIN3A (see all 73):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-607 hsa-miR-376b hsa-miR-3146 hsa-miR-146a hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSIN3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIN3A
    Predesigned siRNA for gene silencing in human, mouse, rat SIN3A

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector (see all 3): SIN3A (NM_001145357)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIN3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIN3A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIN3A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIN3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIN3A_HUMAN, Q96ST3: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IEA--
    GO:0000785chromatin ----
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    SIN3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIN3A About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30
    DNA Methylation and Transcriptional Repression0.30
    4GPCR Pathway
    Estrogen Pathway0.55
    5Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIN3A (see all 8)
        SMAD Signaling Network
    DNA Methylation and Transcriptional Repression
    Nur77 Signaling in T-Cell
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for SIN3A
        Chromatin Regulation / Acetylation

    4 GeneGo (Thomson Reuters) Pathways for SIN3A
        Signal transduction Activin A signaling regulation
    Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for SIN3A (see all 9)
        EGFR1 Signaling Pathway
    Hedgehog Signaling Pathway
    Delta-Notch Signaling Pathway
    RB in Cancer
    Regulation of nuclear SMAD2/3 signaling

    3 Reactome Pathways for SIN3A
        Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Factors involved in megakaryocyte development and platelet production
    NoRC negatively regulates rRNA expression


    3 Kegg Pathways  (Kegg details for SIN3A):
        Thyroid hormone signaling pathway
    Huntington's disease
    Transcriptional misregulation in cancer


    SIN3A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SIN3A: 
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SIN3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIN3A (Q96ST31, 2, 3 ENSP000003536224) via UniProtKB, MINT, STRING, and/or I2D (see all 1174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=4 STRING: ENSP00000352980
    HIST1H4CP628053, ENSP000003670344I2D: score=4 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=4 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=4 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
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    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0001701in utero embryonic development IEA--
    GO:0002218activation of innate immune response IMP--
    GO:0002230positive regulation of defense response to virus by host IMP--
    GO:0006260DNA replication IEA--

    SIN3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIN3A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIN3A gene (3 alternative transcripts): 
    NM_001145357.1  NM_001145358.1  NM_015477.2  

    Unigene Cluster for SIN3A:

    SIN3 transcription regulator homolog A (yeast)
    Hs.513039  [show with all ESTs]
    Unigene Representative Sequence: NM_001145358
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394947(uc002bai.3 uc002baj.3 uc010uml.2) ENST00000360439
    ENST00000394949 ENST00000566640 ENST00000570124 ENST00000570021 ENST00000564778
    ENST00000562776 ENST00000568431 ENST00000567289(uc002bak.4) ENST00000570115
    ENST00000568309 ENST00000568190 ENST00000568919 ENST00000565264
    miRNA
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    Block miRNA regulation of human, mouse, rat SIN3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIN3A (see all 73):
    hsa-miR-323-3p hsa-miR-576-3p hsa-miR-607 hsa-miR-376b hsa-miR-3146 hsa-miR-146a hsa-miR-3613-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSIN3A 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SIN3A (NM_001145357)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIN3A
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SIN3A
      QuantiFast Probe-based Assays in human, mouse, rat SIN3A

    Additional mRNA sequence: 

    AF418569.1 AK027559.1 AK074800.1 AK074903.1 AK096477.1 AL117513.1 AL832463.1 AY044430.1 
    BC018973.1 BC030563.1 BC041047.1 BC052275.1 BC137098.1 BC137099.1 BX649162.1 

    18 DOTS entries:

    DT.100784834  DT.95114567  DT.213637  DT.121052901  DT.91702664  DT.70102824  DT.100837241  DT.308404 
    DT.91980536  DT.99994070  DT.100784838  DT.100695916  DT.102839747  DT.121052713  DT.91767879  DT.95249365 
    DT.95275350  DT.95121958 

    Selected AceView cDNA sequences (see all 219):

    AA359088 CA455409 BQ071885 BQ637378 AA291438 AA598441 AL832463 AA700225 
    CF130266 BM468239 AA357028 CR602001 AI918822 AK096477 BQ689570 AW593445 
    CK429896 BQ882035 AK074903 BF510284 BU196686 AI498259 BQ651199 CN483996 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIN3A (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:              -     -     -     -     -     -                       -                                                                                       
    SP2:                          -     -     -     -                       -                                                                                       
    SP3:                                -     -     -                       -                                                                                       
    SP4:                                            -                       -                                                                                       
    SP5:                                                                    -                                                                                       

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27
    SP1:                                -                           
    SP2:                                -                           
    SP3:                                -                           
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for SIN3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SIN3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACTGCTC
    SIN3A Expression
    About this image


    SIN3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    SIN3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIN3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513039
        Pathway & Disease-focused RT2 Profiler PCR Array including SIN3A: 
              Huntington's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SIN3A gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sin3a1 , 5 transcriptional regulator, SIN3A (yeast)1, 5 90.91(n)1
    98.11(a)1
      9 (30.89 cM)5
    204661  NM_001110350.11  NP_001103820.11 
     570720405 
    chicken
    (Gallus gallus)
    Aves SIN3A1 SIN3 transcription regulator homolog A (yeast) 81.95(n)
    94.16(a)
      415307  XM_004943705.1  XP_004943762.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIN3A6
    SIN3 transcription regulator family member A
    45(a)
    1 ↔ 1
    GL344197.1(1659-3380)
    African clawed frog
    (Xenopus laevis)
    Amphibia Sin32 transcription co-repressor Sin3 77.17(n)    AF154112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb95g112 Transcribed sequence with moderate similarity to protein more 77.09(n)    57048704 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sin3A1 Sin3A 58.9(n)
    60.59(a)
      36382  NM_001259353.1  NP_001246282.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sin-36
    Protein SIN-3, isoform b (sin-3) mRNA, complete cd...
    13(a)
    1 → many
    I(8416832-8425042) WBGene00004117
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIN3(YOL004W)4 Component of the Sin3p-Rpd3p histone deacetylase complex, more   --   15(316938-321548) 854158  NP_014639.1 


    ENSEMBL Gene Tree for SIN3A (if available)
    TreeFam Gene Tree for SIN3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIN3A gene
    SIN3B2  
    1 SIMAP similar gene for SIN3A using alignment to 9 protein entries:     SIN3A_HUMAN (see all proteins):
    SIN3B

    SIN3A for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SIN3A (see all 6)
    PGOHUM00000238711 PGOHUM00000246854 PGOHUM00000246909 PGOHUM00000246924 PGOHUM00000247246


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIN3A (see all 1519)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395417491,2
    Cuntested175705226(+) GGTGGA/GAATCT 6 P S mis10--------
    rs105399961,2
    C--55789562(+) AAAAAAA/-TTAGC 3 -- int11Minor allele frequency- -:0.50NA 2
    rs115511221,2
    C,H--75663014(-) TTTTTC/TTTATT 3 -- ut312Minor allele frequency- T:0.01NS NA 182
    rs1865433381,2
    --75663222(+) TCCCTA/GCTTCA 3 -- ut310--------
    rs1379867181,2
    --75663229(+) TTCACA/GGTATT 3 -- ut310--------
    rs791944501,2
    C--75663304(+) ATTTA-/C/CAA 
            
    AAAAA
    6 -- ut310--------
    rs591836561,2
    C--75663305(+) TTTAC-/AAAAAA 3 -- ut311Minor allele frequency- A:0.00NA 2
    rs1905629201,2
    --75663406(+) GTCTTA/GTACAT 3 -- ut310--------
    rs1494978621,2
    --75663431(+) TAAATC/GTGAAG 3 -- ut310--------
    rs115511231,2
    C--75663441(-) AGTACT/CGTGGC 3 -- ut31 ese32Minor allele frequency- C:0.00NA 4

    HapMap Linkage Disequilibrium report for SIN3A (75661720 - 75748183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SIN3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749894CNV Deletion23290073
    esv2749895CNV Deletion23290073
    nsv1615CNV Insertion18451855
    dgv2414n71CNV Loss21882294
    nsv904386CNV Gain21882294
    nsv827389CNV Gain20364138
    nsv525265CNV Gain19592680
    nsv904387CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIN3A
    DNA2.0 Custom Variant and Variant Library Synthesis for SIN3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607776    OMIM disorders: --

    Selected diseases for SIN3A (see all 28):    
    About MalaCards
    rett syndrome    synovial sarcoma    acute promyelocytic leukemia    dermatomyositis
    burkitt's lymphoma    huntington's disease    retinoblastoma    acute myeloid leukemia
    coronary artery disease    mental retardation    sarcoma    myeloid leukemia
    leukemia    neuroblastoma    hepatitis b    thyroiditis
    pancreatic cancer    hypoxia    tonsillitis    melanoma

    1 disease from the University of Copenhagen DISEASES database for SIN3A:
    Rett syndrome

    SIN3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIN3A

    Export disorders for SIN3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIN3A gene, integrated from 10 sources (see all 251):
    (articles sorted by number of sources associating them with SIN3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PubMed id 11259580)1, 2, 9 Mathur M.... Samuels H.H. (Mol. Cell. Biol. 2001)
    2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    4. TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins. (PubMed id 17803295)1, 2 Pungaliya P.... Rubin E.H. (J. Proteome Res. 2007)
    5. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. (PubMed id 16820529)1, 2 Viiri K.M.... Lohi O. (Nucleic Acids Res. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PubMed id 15451426)1, 2 Nikolaev A.Y.... Gu W. (Biochem. Biophys. Res. Commun. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)1, 2 Wu K.... Pestell R.G. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25942 HGNC: 19353 AceView: SIN3A Ensembl:ENSG00000169375 euGenes: HUgn25942
    ECgene: SIN3A Kegg: 25942 H-InvDB: SIN3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIN3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SIN3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIN3A gene:
    Search GeneIP for patents involving SIN3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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