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Aliases for SIN3A Gene

Aliases for SIN3A Gene

  • SIN3 Transcription Regulator Family Member A 2 3 5
  • Histone Deacetylase Complex Subunit Sin3a 3 4
  • Transcriptional Corepressor Sin3a 3 4
  • SIN3 Homolog A, Transcription Regulator (Yeast) 2
  • SIN3 Transcription Regulator Homolog A (Yeast) 2
  • SIN3 Homolog A, Transcription Regulator 3
  • SIN3 Transcription Regulator Homolog A 3
  • Paired Amphipathic Helix Protein Sin3a 3
  • Transcriptional Co-Repressor Sin3A 3
  • Transcriptional Regulator, SIN3A 3
  • WITKOS 3

External Ids for SIN3A Gene

Previous GeneCards Identifiers for SIN3A Gene

  • GC15M071541
  • GC15M068754
  • GC15M073239
  • GC15M073379
  • GC15M073450
  • GC15M075661
  • GC15M052420

Summaries for SIN3A Gene

Entrez Gene Summary for SIN3A Gene

  • The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIN3A Gene

SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Diseases associated with SIN3A include Chromosome 15Q24 Deletion Syndrome Chromosome 15Q24 Duplication Syndrome, Included and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is SIN3B.

UniProtKB/Swiss-Prot for SIN3A Gene

  • Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).

Gene Wiki entry for SIN3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3A Gene

Genomics for SIN3A Gene

Regulatory Elements for SIN3A Gene

Enhancers for SIN3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F075384 0.2 ENCODE 11.2 +71.4 71448 0.2 GATA3 SIN3A RPL13P4 MAN2C1
GH15F075420 1.1 ENCODE 10.9 +34.9 34888 0.2 ZNF335 GLIS2 RBAK SCRT2 ZBTB26 PRDM1 TRIM28 ZXDB MAN2C1 MIR631 SIN3A ENSG00000261714 ENSG00000276744
GH15F075366 0.5 ENCODE 10.8 +87.1 87088 3.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DNM1P35 FBXO22 ENSG00000260274 SNX33 SNUPN ENSG00000203392 PTPN9 LOC101929333 EDC3 SIN3A
GH15F075637 0.6 ENCODE 10.6 -183.6 -183646 4.5 HDGF CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MAN2C1 SNUPN LOC441728 DNM1P49 LOC105370902 ENSG00000261232 ENSG00000203392 CSPG4 ENSG00000260274 MIR631
GH15F075541 1.1 Ensembl ENCODE 10.6 -87.7 -87650 3.6 CTCF KLF1 PKNOX1 TAF1 TAL1 FEZF1 ZIC2 ZNF664 ZNF121 FOSL1 ENSG00000260274 SIN3A MAN2C1 SNUPN ENSG00000259931 PTPN9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIN3A on UCSC Golden Path with GeneCards custom track

Genomic Location for SIN3A Gene

Chromosome:
15
Start:
75,369,379 bp from pter
End:
75,455,842 bp from pter
Size:
86,464 bases
Orientation:
Minus strand

Genomic View for SIN3A Gene

Genes around SIN3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIN3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIN3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIN3A Gene

Proteins for SIN3A Gene

  • Protein details for SIN3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ST3-SIN3A_HUMAN
    Recommended name:
    Paired amphipathic helix protein Sin3a
    Protein Accession:
    Q96ST3
    Secondary Accessions:
    • B2RNS5
    • Q8N8N4
    • Q8NC83
    • Q8WV18
    • Q96L98
    • Q9UFQ1

    Protein attributes for SIN3A Gene

    Size:
    1273 amino acids
    Molecular mass:
    145175 Da
    Quaternary structure:
    • Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11 (By similarity). Interacts with PPHLN1 (PubMed:17963697). Found in a complex with YY1, GON4L and HDAC1 (By similarity). Interacts (via PAH2) with FOXK1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SIN3A Gene

neXtProt entry for SIN3A Gene

Post-translational modifications for SIN3A Gene

  • SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
  • Ubiquitination at Lys 343, Lys 727, and Lys 747
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIN3A (SIN3A)
  • Abcam antibodies for SIN3A

No data available for DME Specific Peptides for SIN3A Gene

Domains & Families for SIN3A Gene

Gene Families for SIN3A Gene

Protein Domains for SIN3A Gene

Suggested Antigen Peptide Sequences for SIN3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ST3

UniProtKB/Swiss-Prot:

SIN3A_HUMAN :
  • Contains 3 PAH (paired amphipathic helix) domains.
Domain:
  • Contains 3 PAH (paired amphipathic helix) domains.
genes like me logo Genes that share domains with SIN3A: view

Function for SIN3A Gene

Molecular function for SIN3A Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).

Gene Ontology (GO) - Molecular Function for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 22783022
GO:0001103 RNA polymerase II repressing transcription factor binding IEA --
GO:0001106 RNA polymerase II transcription corepressor activity IBA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SIN3A: view
genes like me logo Genes that share phenotypes with SIN3A: view

Animal Models for SIN3A Gene

MGI Knock Outs for SIN3A:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIN3A Gene

Localization for SIN3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIN3A Gene

Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIN3A Gene COMPARTMENTS Subcellular localization image for SIN3A gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000785 chromatin IEA --
GO:0005634 nucleus ISS,IDA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SIN3A: view

Pathways & Interactions for SIN3A Gene

genes like me logo Genes that share pathways with SIN3A: view

Gene Ontology (GO) - Biological Process for SIN3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22783022
GO:0001701 in utero embryonic development IEA --
GO:0002218 activation of innate immune response IMP 22783022
GO:0002230 positive regulation of defense response to virus by host IMP 22783022
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with SIN3A: view

No data available for SIGNOR curated interactions for SIN3A Gene

Transcripts for SIN3A Gene

Unigene Clusters for SIN3A Gene

SIN3 transcription regulator homolog A (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIN3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - - -
SP11:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SIN3A Gene

GeneLoc Exon Structure for
SIN3A
ECgene alternative splicing isoforms for
SIN3A

Expression for SIN3A Gene

mRNA expression in normal human tissues for SIN3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIN3A Gene

This gene is overexpressed in Lymph node (15.3) and Peripheral blood mononuclear cells (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIN3A Gene



Protein tissue co-expression partners for SIN3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIN3A Gene:

SIN3A

SOURCE GeneReport for Unigene cluster for SIN3A Gene:

Hs.513039
genes like me logo Genes that share expression patterns with SIN3A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIN3A Gene

Orthologs for SIN3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIN3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIN3A 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia SIN3A 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIN3A 34 35
  • 93.43 (n)
dog
(Canis familiaris)
Mammalia SIN3A 34 35
  • 93.11 (n)
mouse
(Mus musculus)
Mammalia Sin3a 34 16 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Sin3a 34
  • 90.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SIN3A 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIN3A 34 35
  • 81.95 (n)
lizard
(Anolis carolinensis)
Reptilia SIN3A 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sin3a 34
  • 74.08 (n)
Str.14936 34
African clawed frog
(Xenopus laevis)
Amphibia Sin3 34
zebrafish
(Danio rerio)
Actinopterygii sin3aa 35
  • 77 (a)
OneToMany
sin3ab 35
  • 75 (a)
OneToMany
wufb95g11 34
fruit fly
(Drosophila melanogaster)
Insecta Sin3A 34 35
  • 58.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007892 34
  • 58.26 (n)
worm
(Caenorhabditis elegans)
Secernentea sin-3 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIN3 35 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3742 35
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4585 34
Species where no ortholog for SIN3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIN3A Gene

ENSEMBL:
Gene Tree for SIN3A (if available)
TreeFam:
Gene Tree for SIN3A (if available)

Paralogs for SIN3A Gene

Paralogs for SIN3A Gene

(1) SIMAP similar genes for SIN3A Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SIN3A: view

Variants for SIN3A Gene

Sequence variations from dbSNP and Humsavar for SIN3A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs879255618 Pathogenic 75,411,696(-) CCCCC(-/C)ACTTC reference, frameshift-variant
rs879255619 Pathogenic 75,410,282(-) TCAGA(-/AAGA)GCAGA reference, frameshift-variant
rs879255620 Pathogenic 75,400,135(-) GGGTT(-/T)CCTTC reference, frameshift-variant
rs879255621 Pathogenic 75,380,702(-) TGGAG(C/T)GATAC reference, stop-gained
rs10152155 -- 75,409,213(+) AAAAA(A/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIN3A Gene

Variant ID Type Subtype PubMed ID
dgv1243n106 CNV deletion 24896259
dgv2621n100 CNV gain 25217958
esv2749894 CNV deletion 23290073
esv2749895 CNV deletion 23290073
esv3636926 CNV gain 21293372
nsv1116463 OTHER inversion 24896259
nsv1615 CNV insertion 18451855
nsv474716 CNV novel sequence insertion 20440878
nsv525265 CNV gain 19592680
nsv827389 CNV gain 20364138
nsv976952 CNV duplication 23825009
nsv977737 CNV duplication 23825009

Variation tolerance for SIN3A Gene

Residual Variation Intolerance Score: 1.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIN3A Gene

Human Gene Mutation Database (HGMD)
SIN3A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIN3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3A Gene

Disorders for SIN3A Gene

MalaCards: The human disease database

(3) MalaCards diseases for SIN3A Gene - From: ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
chromosome 15q24 deletion syndrome chromosome 15q24 duplication syndrome, included
  • 15q24 microdeletion syndrome
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards
Search SIN3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIN3A

Genetic Association Database (GAD)
SIN3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIN3A
genes like me logo Genes that share disorders with SIN3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIN3A Gene

Publications for SIN3A Gene

  1. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PMID: 11259580) Mathur M. … Samuels H.H. (Mol. Cell. Biol. 2001) 3 4 22 64
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
  4. Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. (PMID: 18535655) Burgio G. … Corona D.F. (PLoS Genet. 2008) 3 22 64
  5. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. (PMID: 18059533) Sekhavat A. … Davie J.R. (Biochem. Cell Biol. 2007) 3 22 64

Products for SIN3A Gene

Sources for SIN3A Gene

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