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SIMC1 Gene

protein-coding   GIFtS: 33
GCID: GC05P175675

SUMO-Interacting Motifs Containing 1

(Previous name: chromosome 5 open reading frame 25)
(Previous symbol: C5orf25)
  Search for SIMC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SUMO-Interacting Motifs Containing 11 2     Chromosome 5 Open Reading Frame 251
C5orf251 2 3     OOMA12
Oocyte Maturation Associated 11 2     PLEIAD2
Platform Element For Inhibition Of Autolytic Degradation1 2     SUMO-Interacting Motif-Containing Protein 12

External Ids:    HGNC: 247791   Entrez Gene: 3754842   Ensembl: ENSG000001700857   UniProtKB: Q8NDZ23   

Export aliases for SIMC1 gene to outside databases

Previous GC identifer: GC05P175666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIMC1 Gene:
SIMC1 (SUMO-interacting motifs containing 1) is a protein-coding gene. GO annotations related to this gene include SUMO polymer binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SIMC1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SIMC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

SIMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIMC1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175675:  view genomic region     (about GC identifiers)

Start:
175,665,365 bp from pter      End:
175,772,994 bp from pter
Size:
107,630 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIMC1_HUMAN, Q8NDZ2 (See protein sequence)
Recommended Name: SUMO-interacting motif-containing protein 1  
Size: 872 amino acids; 96838 Da
Subunit: Interacts (via SIM domains) with SUMO1 and SUMO2
Secondary accessions: J3KQQ8 Q6NXN8 Q6ZTU4 Q8IZ15
Alternative splicing: 4 isoforms:  Q8NDZ2-1   Q8NDZ2-2   Q8NDZ2-3   Q8NDZ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIMC1: NX_Q8NDZ2

Explore proteomics data for SIMC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys543
  • Modification sites at PhosphoSitePlus

  • See SIMC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940969.3  
    ENSEMBL proteins: 
     ENSP00000409287   ENSP00000406571   ENSP00000331311   ENSP00000342075   ENSP00000410552  

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8NDZ2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032184SUMO polymer binding IDA--
         
    SIMC1 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-1226-3p (MIRT036510)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIMC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIMC1
    Interactions:

        Search GeneGlobe Interaction Network for SIMC1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SIMC1 (Q8NDZ22, 3 ENSP000003420754) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253088 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253088 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIMC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIMC1 gene: 
    NM_198567.4  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430704(uc003mdr.3) ENST00000443967(uc003mdt.4 uc003mds.4)
    ENST00000495423 ENST00000508769 ENST00000467472 ENST00000514128 ENST00000503595
    ENST00000481515 ENST00000332772(uc003mdv.3) ENST00000341199 ENST00000429602(uc011dfk.1)

    miRNA
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    OriGene qPCR primer pairs and template standards for SIMC1
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      QuantiFast Probe-based Assays in human, mouse, rat SIMC1

    Selected AceView cDNA sequences (see all 92):

    D44804 AI470661 AI149641 BI831073 BU684936 BE348413 CR602378 BI831728 
    CD108467 AA293700 AL138110 BC073880 AI871879 AA804603 CA427292 BF513104 
    BC032390 BU517158 AI824305 BC066980 AA292933 AA833709 BX400201 BC037298 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIMC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -           -                 -                                 
    SP2:                                                  -                                 
    SP3:                                -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for SIMC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SIMC1 Expression
    About this image

    SIMC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIMC1 Protein Expression
        Custom PCR Arrays for SIMC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIMC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIMC1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Simc11 , 5 RIKEN cDNA 4732471D19 gene5
    SUMO-interacting motifs containing 11
    87.6(n)1
    93.1(a)1
      13 (28.74 cM)5
    3197191  NM_176987.41  NP_795961.31 
     545037795 
    chicken
    (Gallus gallus)
    Aves SIMC16
    SUMO-interacting motifs containing 1
    48(a)
    1 ↔ 1
    13(9752006-9757146)
    lizard
    (Anolis carolinensis)
    Reptilia SIMC16
    SUMO-interacting motifs containing 1
    38(a)
    1 ↔ 1
    GL343548.1(370386-389729)
    zebrafish
    (Danio rerio)
    Actinopterygii SIMC16
    SUMO-interacting motifs containing 1
    19(a)
    1 ↔ 1
    14(52610970-52630071) ENSDARG00000089939


    ENSEMBL Gene Tree for SIMC1 (if available)
    TreeFam Gene Tree for SIMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIMC1 gene

    SIMC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SIMC1
    PGOHUM00000235465


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIMC1 (see all 1997)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395271161,2
    --175663379(+) TCCCCA/GTCCAC 1 -- us2k10--------
    rs586066951,2
    --175663486(+) AATTCG/TTTTTC 1 -- us2k10--------
    rs1816979571,2
    --175663557(+) CTGAGA/GCTGAG 1 -- us2k10--------
    rs1510688971,2
    C--175663559(+) GAGACC/TGAGTA 1 -- us2k10--------
    rs1409782181,2
    --175663560(+) AGACTA/GAGTAA 1 -- us2k10--------
    rs1863813621,2
    --175663681(+) CGAAGG/TGGGAG 1 -- us2k10--------
    rs1908273371,2
    --175663760(+) GAACTC/TGTTAT 1 -- us2k10--------
    rs1809958431,2
    --175664057(+) CTCCTC/GCCTCA 1 -- us2k10--------
    rs563732481,2
    C--175664101(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs1999860461,2
    C--175665052(+) CACTCA/GGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIMC1 (175665365 - 175772994 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIMC1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIMC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIMC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIMC1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SIMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)1, 2, 3 Sun H. and Hunter T. (J. Biol. Chem. 2012)
    2. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. (PubMed id 23707407)1, 3 Ono Y....Sorimachi H. (J. Mol. Biol. 2013)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375484 HGNC: 24779 AceView: FLJ44216 Ensembl:ENSG00000170085 euGenes: HUgn375484
    ECgene: SIMC1 H-InvDB: SIMC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIMC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIMC1 gene:
    Search GeneIP for patents involving SIMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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