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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIMC1 Gene

protein-coding   GIFtS: 34
GCID: GC05P175666

SUMO-Interacting Motifs Containing 1

(Previous name: chromosome 5 open reading frame 25)
(Previous symbol: C5orf25)
  Search for SIMC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SUMO-Interacting Motifs Containing 11 2     Chromosome 5 Open Reading Frame 251
C5orf251 2 3     OOMA12
Oocyte Maturation Associated 11 2     PLEIAD2
Platform Element For Inhibition Of Autolytic Degradation1 2     SUMO-Interacting Motif-Containing Protein 12

External Ids:    HGNC: 247791   Entrez Gene: 3754842   Ensembl: ENSG000001700857   UniProtKB: Q8NDZ23   

Export aliases for SIMC1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIMC1 Gene: 
SIMC1 (SUMO-interacting motifs containing 1) is a protein-coding gene. GO annotations related to this gene include SUMO polymer binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SIMC1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SIMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

SIMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIMC1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175666:  view genomic region     (about GC identifiers)

Start:
175,665,365 bp from pter      End:
175,772,994 bp from pter
Size:
107,630 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIMC1_HUMAN, Q8NDZ2 (See protein sequence)
Recommended Name: SUMO-interacting motif-containing protein 1  
Size: 872 amino acids; 96838 Da
Subunit: Interacts (via SIM domains) with SUMO1 and SUMO2
Secondary accessions: J3KQQ8 Q6NXN8 Q6ZTU4 Q8IZ15
Alternative splicing: 4 isoforms:  Q8NDZ2-1   Q8NDZ2-2   Q8NDZ2-3   Q8NDZ2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIMC1: NX_Q8NDZ2

Explore proteomics data for SIMC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NDZ2

  • SIMC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIMC1 Protein Expression
    REFSEQ proteins: NP_940969.3  
    ENSEMBL proteins: 
     ENSP00000409287   ENSP00000406571   ENSP00000331311   ENSP00000342075   ENSP00000410552  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NDZ2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032184SUMO polymer binding IDA--
         
    SIMC1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIMC1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/15 Interacting proteins for SIMC1 (Q8NDZ22, 3 ENSP000003420754) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253088 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253088 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253088 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIMC1

    Search CenterWatch for drugs/clinical trials and news about SIMC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIMC1 gene: 
    NM_198567.4  

    Unigene Cluster for SIMC1:

    SUMO-interacting motifs containing 1
    Hs.719847  [show with all ESTs]
    Unigene Representative Sequence: BC037298
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430704(uc003mdr.3) ENST00000443967(uc003mdt.4 uc003mds.4)
    ENST00000495423 ENST00000508769 ENST00000467472 ENST00000514128 ENST00000503595
    ENST00000481515 ENST00000332772(uc003mdv.3) ENST00000341199 ENST00000429602(uc011dfk.1)

    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIMC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIMC1
    Sirion Biotech Customized lentivirus for stable overexpression of SIMC1 
                         Customized lentivirus expression plasmids for stable overexpression of SIMC1 
    Primer
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    OriGene qPCR primer pairs and template standards for SIMC1
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    Additional mRNA sequence: 

    AK126204.1 AK299336.1 BC032390.1 BC037298.1 BC073880.1 L37702.1 

    9 DOTS entries:

    DT.100783961  DT.95362791  DT.92473015  DT.95090831  DT.100010883  DT.101978039  DT.65285350  DT.120886592 
    DT.92041447 

    24/92 AceView cDNA sequences (see all 92):

    AA293700 AI871879 CA427292 BU684936 BC073880 AI470661 BE348413 CR602378 
    D44804 AA804603 CD108467 BI831728 AL138110 BC032390 BF513104 BU517158 
    AI149641 AI824305 BI831073 BV177693 AI024604 BM052805 AW993901 BQ222435 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIMC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -           -                 -                                 
    SP2:                                                  -                                 
    SP3:                                -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for SIMC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SIMC1 Expression
    About this image


    See SIMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIMC1

    SOURCE GeneReport for Unigene cluster: Hs.719847
        SABiosciences Custom PCR Arrays for SIMC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIMC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SIMC1 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Simc15
    4732471D19Rik1
    RIKEN cDNA 4732471D19 gene1, 5 87.6(n)1
    93.1(a)1
      13 (28.74 cM)5
    3197191  NM_176987.41  NP_795961.31 
     545037795 
    chicken
    (Gallus gallus)
    Aves C13H5orf251 chromosome 13 open reading frame, human C5orf25 62.66(n)
    53.71(a)
      416231  XM_414554.3  XP_414554.1 
    lizard
    (Anolis carolinensis)
    Reptilia C5ORF256
    Uncharacterized protein
    36(a)
    1 ↔ 1
    GL343548.1(370386-389729)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001502041 uncharacterized protein C5orf25-like 49.68(n)
    39.69(a)
      100150204  XM_001922548.1  XP_001922583.1 


    ENSEMBL Gene Tree for SIMC1 (if available)
    TreeFam Gene Tree for SIMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIMC1 gene

    SIMC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SIMC1
    PGOHUM00000235465


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1997 SNPs in SIMC1 are shown (see all 1997)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395271161,2
    --175663379(+) TCCCCA/GTCCAC 1 -- us2k10--------
    rs586066951,2
    --175663486(+) AATTCG/TTTTTC 1 -- us2k10--------
    rs1816979571,2
    --175663557(+) CTGAGA/GCTGAG 1 -- us2k10--------
    rs1510688971,2
    C--175663559(+) GAGACC/TGAGTA 1 -- us2k10--------
    rs1409782181,2
    --175663560(+) AGACTA/GAGTAA 1 -- us2k10--------
    rs1863813621,2
    --175663681(+) CGAAGG/TGGGAG 1 -- us2k10--------
    rs1908273371,2
    --175663760(+) GAACTC/TGTTAT 1 -- us2k10--------
    rs1809958431,2
    --175664057(+) CTCCTC/GCCTCA 1 -- us2k10--------
    rs563732481,2
    C--175664101(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs1999860461,2
    C--175665052(+) CACTCA/GGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIMC1 (175665365 - 175772994 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIMC1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SIMC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIMC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIMC1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SIMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)1, 2, 3 Sun H. and Hunter T. (2012)
    2. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. (PubMed id 23707407)1, 3 Ono Y....Sorimachi H. (2013)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375484 HGNC: 24779 AceView: FLJ44216 Ensembl:ENSG00000170085 euGenes: HUgn375484
    ECgene: SIMC1 H-InvDB: SIMC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIMC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIMC1 gene:
    Search GeneIP for patents involving SIMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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