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Aliases for SIMC1 Gene

Aliases for SIMC1 Gene

  • SUMO Interacting Motifs Containing 1 2 3
  • SUMO-Interacting Motifs Containing 1 2 3 5
  • Platform Element For Inhibition Of Autolytic Degradation 2 3
  • Oocyte Maturation Associated 1 2 3
  • C5orf25 3 4
  • Chromosome 5 Open Reading Frame 25 2
  • PLEIAD 3
  • OOMA1 3

External Ids for SIMC1 Gene

Previous HGNC Symbols for SIMC1 Gene

  • C5orf25

Previous GeneCards Identifiers for SIMC1 Gene

  • GC05P175666
  • GC05P175675

Summaries for SIMC1 Gene

GeneCards Summary for SIMC1 Gene

SIMC1 (SUMO Interacting Motifs Containing 1) is a Protein Coding gene. GO annotations related to this gene include SUMO polymer binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIMC1 Gene

Genomics for SIMC1 Gene

Regulatory Elements for SIMC1 Gene

Promoters for SIMC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIMC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIMC1 Gene

176,238,367 bp from pter
176,345,991 bp from pter
107,625 bases
Plus strand

Genomic View for SIMC1 Gene

Genes around SIMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIMC1 Gene

Proteins for SIMC1 Gene

  • Protein details for SIMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SUMO-interacting motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • J3KQQ8
    • Q6NXN8
    • Q6ZTU4
    • Q8IZ15

    Protein attributes for SIMC1 Gene

    872 amino acids
    Molecular mass:
    96838 Da
    Quaternary structure:
    • Interacts (via SIM domains) with SUMO1 and SUMO2.

    Alternative splice isoforms for SIMC1 Gene


neXtProt entry for SIMC1 Gene

Proteomics data for SIMC1 Gene at MOPED

Post-translational modifications for SIMC1 Gene

  • Ubiquitination at Lys 543
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIMC1 Gene

Domains & Families for SIMC1 Gene

Protein Domains for SIMC1 Gene


Suggested Antigen Peptide Sequences for SIMC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIMC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SIMC1 Gene

Function for SIMC1 Gene

genes like me logo Genes that share phenotypes with SIMC1: view

Animal Model Products

CRISPR Products

miRNA for SIMC1 Gene

miRTarBase miRNAs that target SIMC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIMC1 Gene

Localization for SIMC1 Gene

Subcellular locations from

Jensen Localization Image for SIMC1 Gene COMPARTMENTS Subcellular localization image for SIMC1 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SIMC1 Gene

Pathways & Interactions for SIMC1 Gene

SuperPathways for SIMC1 Gene

No Data Available

Interacting Proteins for SIMC1 Gene

Gene Ontology (GO) - Biological Process for SIMC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SIMC1 Gene

Drugs & Compounds for SIMC1 Gene

No Compound Related Data Available

Transcripts for SIMC1 Gene

Unigene Clusters for SIMC1 Gene

SUMO-interacting motifs containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIMC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: -

Relevant External Links for SIMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIMC1 Gene

mRNA expression in normal human tissues for SIMC1 Gene

mRNA differential expression in normal tissues according to GTEx for SIMC1 Gene

This gene is overexpressed in Ovary (x4.9).

Protein differential expression in normal tissues from HIPED for SIMC1 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIMC1 Gene

SOURCE GeneReport for Unigene cluster for SIMC1 Gene Hs.719847

genes like me logo Genes that share expression patterns with SIMC1: view

Protein tissue co-expression partners for SIMC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SIMC1 Gene

Orthologs for SIMC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIMC1 35
  • 88.23 (n)
  • 93.09 (a)
SIMC1 36
  • 40 (a)
(Canis familiaris)
Mammalia SIMC1 35
  • 92.01 (n)
  • 95.16 (a)
SIMC1 36
  • 43 (a)
(Mus musculus)
Mammalia Simc1 35
  • 87.6 (n)
  • 93.1 (a)
Simc1 16
Simc1 36
  • 28 (a)
(Pan troglodytes)
Mammalia SIMC1 35
  • 99.76 (n)
  • 99.76 (a)
SIMC1 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Simc1 35
  • 87.77 (n)
  • 94.33 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
-- 36
  • 49 (a)
(Gallus gallus)
Aves SIMC1 36
  • 48 (a)
(Anolis carolinensis)
Reptilia SIMC1 36
  • 38 (a)
(Danio rerio)
Actinopterygii SIMC1 36
  • 19 (a)
Species with no ortholog for SIMC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIMC1 Gene

Gene Tree for SIMC1 (if available)
Gene Tree for SIMC1 (if available)

Paralogs for SIMC1 Gene Pseudogenes for SIMC1 Gene

genes like me logo Genes that share paralogs with SIMC1: view

No data available for Paralogs for SIMC1 Gene

Variants for SIMC1 Gene

Sequence variations from dbSNP and Humsavar for SIMC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2001605 -, - 176,290,243(+) AGCCT(C/T)CTCAT intron-variant, reference, missense
rs17857141 - 176,295,043(+) TCAAA(A/G)ATTAG nc-transcript-variant, reference, missense
rs17853733 - 176,337,105(+) TGAGC(A/G)TCTGC nc-transcript-variant, reference, missense
rs186896 -- 176,323,994(+) AAAAA(A/T)AAAAA intron-variant
rs180509 -- 176,316,901(+) AGAAT(A/C)ATTTG intron-variant

Variation tolerance for SIMC1 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIMC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SIMC1 Gene

Disorders for SIMC1 Gene

Relevant External Links for SIMC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIMC1 Gene

Publications for SIMC1 Gene

  1. PolySUMO-binding proteins identified through a string search. (PMID: 23086935) Sun H. … Hunter T. (J. Biol. Chem. 2012) 2 3 4 67
  2. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. (PMID: 23707407) Ono Y. … Sorimachi H. (J. Mol. Biol. 2013) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for SIMC1 Gene

Sources for SIMC1 Gene

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