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SIM2 Gene

protein-coding GIFtS: 57

GC21P036993

single-minded homolog 2 (Drosophila)
(Previous name: single-minded (Drosophila) homolog 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SIM)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
MGC119447 ^¹, ²
SIM ^²
bHLHe15 ^¹, ²

Descriptions
human transcription factor SIM2, homolog of the Drosophila single-minded gene SIM1 ⁹
single-minded (Drosophila) homolog 2 ^¹
single-minded homolog 2 ^²
single-minded homolog 2 (Drosophila) ^²
single-minded homolog 2, short isoform ^²
transcription factor SIM2 ^²

External Ids
HGNC: 10883¹
Entrez Gene: 6493²
UniProtKB: Q14190³
Ensembl: ENSG00000159263⁷

Search outside databases for aliases for SIM2 gene

Previous GC identifers: GC21P034649 GC21P036991 GC21P036992

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SIM2:

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene

encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps

within the so-called Down syndrome chromosomal region. Based on the mapping position, its

potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed

that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq]

UniProtKB/Swiss-Prot: SIM2_HUMAN, Q14190

Function: Transcription factor that may be a master gene of CNS development in cooperation with

Arnt. It may have pleiotropic effects in the tissues expressed during development

Gene Wiki entry for SIM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2|21q22.13 Ensembl cytogenetic band: 21q22.13 HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band: 21q22.13

SIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21P036993:	GeneLoc	Nature:405,311-319
Start:	36,993,861 bp from pter	23,648,420 bp from centromere
End:	37,044,088 bp from pter	23,698,647 bp from centromere
Size:	50,228 bases	50,228 bases
Orientation:	plus strand	plus strand

RefSeq DNA sequence:

NC_000021.7 NT_011512.10

Whole chromosome sequencing:
cDNA sequence:	U80456
genomic clones:	KB594G10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SIM2_HUMAN, Q14190 (See protein sequence)

Recommended Name: Single-minded homolog 2

Size: 667 amino acids; 73219 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2

and ARNT

Subcellular location: Nucleus

Secondary accessions: O60766 Q15470 Q15471 Q15472 Q15473 Q16532

Alternative splicing: 2 isoforms: Q14190-1 Q14190-2

REFSEQ proteins (2 alternative transcripts):

NP_005060.1 NP_033664.2

ENSEMBL proteins:

ENSP00000290399

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for SIM2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SIM2
	Sigma-Aldrich Antibodies for SIM2
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (SIM2)
	Novus Biologicals Antibodies for SIM2

Assays for SIM2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14190

ProtoNet protein and cluster: Q14190

5/7 Blocks protein families (see all 7 ):

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB010578 Single-minded

UniProtKB/Swiss-Prot: SIM2_HUMAN, Q14190

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

Similarity: Contains 1 Single-minded C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SIM2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SIM2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_009586

Applied Biosystems Silencer® siRNAs for SIM2

Sigma-Aldrich siRNA for SIM2

Sigma-Aldrich shRNA for SIM2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005069
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005069
untagged cDNA clones in CMV expression vector (see all 2): NM_005069

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005069

UniProtKB/Swiss-Prot: SIM2_HUMAN, Q14190

Function: Transcription factor that may be a master gene of CNS development in cooperation with

Arnt. It may have pleiotropic effects in the tissues expressed during development

Genatlas biochemistry entry for SIM2:

Drosophila master regulator of fruit fly neurogenesis,single-minded 2 homolog,expressed in

brain,kidney,skeletal muscle,prostate,located in the Down syndrome critical region with four

alternatively spliced isoforms,involved in the development of midline cells in the central nervous

system

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sim2):

craniofacial	digestive/alimentary	growth/size	lethality-postnatal	nervous system
respiratory system	skeleton

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	8661114 9199934
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0016564	transcription repressor activity	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SIM2

5/7 Interacting proteins for SIM2 (ENSP00000290399³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARNT	ENSP00000315637³	STRING (score=.987)
PARK2	ENSP00000355865³	STRING (score=.95)
MYOM2	ENSP00000262113³	STRING (score=.914)
TWIST1	ENSP00000242261³	STRING (score=.867)
EGFR	ENSP00000275493³	STRING (score=.866)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	TAS	9199934

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SIM2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SIM2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SIM2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_009586

Sigma-Aldrich siRNA for SIM2

Sigma-Aldrich shRNA for SIM2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005069 NM_009586

REFSEQ mRNAs for SIM2 gene (2 alternative transcripts):

NM_005069.3 NM_009586.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005069 NM_009586

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005069
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005069
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005069

Additional cDNA sequence:

AJ001858.1 AJ001859.1 BC052313.1 BC067104.1 BC110444.2 U80456.1 U80457.1 X83515.1

X83516.1

3 DOTS entries:

DT.311079 DT.311080 DT.100020010

24/34 AceView cDNA sequences (see all 34 ):

BE348303 X83514 NM_005069 BM817917 X84790 AI681666 X83515 BU859214

BF000531 AJ001858 AI625864 U80457 BU931875 U80456 BM848475 BM846210

BC067104 NM_009586 AJ001859 BC052313 BU931794 BU859043 BI255303 X83516

highest scoring ESTs for SIM2:

U80456 AA983560 AI208499 AI625864 AI681666 AI913212 BF095326 BG026400 BI255303 F02586

Unigene Cluster for SIM2:

Single-minded homolog 2 (Drosophila)

Hs.146186 [show with all ESTs]

Unigene Representative Sequence: NM_005069

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SIM2

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12
SP1:									-																		-		-
SP2:									-
SP3:									-
SP4:

About this scheme

ECgene alternative splicing isoforms for SIM2

1 Ensembl transcript including schematic representation:

ENST00000290399

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SIM2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SIM2

¹ / ² / ³

6 probe-sets matching SIM2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39608_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.70	U80456	1.00	1.00	1.00	1
39609_at²^{, 3}	U95-A	1	1.00	1.00	0.38	1.47	U80457	0.80	1.00	0.91	1
206558_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005069	0.60	1.00	0.82	1
208157_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_009586	0.60	1.00	0.82	1
206558_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208157_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.146186
Expression variation in blood from EXPOLDB for SIM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SIM2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SIM2¹	--	single-minded homolog 2 (Drosophila)	91.89(n) 95.5(a)	607987 XM_844426.1 XP_849519.1
chimpanzee (Pan troglodytes)	SIM2¹	--	single-minded homolog 2 (Drosophila)	99.4(n) 99.55(a)	474107 XM_001169453.1 XP_001169453.1
rat (Rattus norvegicus)	Sim2¹	--	single-minded homolog 2 (Drosophila)	87.6(n) 90.7(a)	304071 XM_221633.3 XP_221633.2
mouse (Mus musculus)	Sim2^{1, 5}	16 (67.57 cM)⁵	single-minded homolog 2 (Drosophila)^{1, 5}	88.31(n)¹ 91.62(a)¹	20465¹ NM_011377.2¹ NP_035507.2¹ AF023864⁵ AF023865⁵ (see all 22)
chicken (Gallus gallus)	SIM2¹	--	single-minded homolog 2 (Drosophila)	73.95(n) 81.67(a)	418515 XM_416724.2 XP_416724.2

About this table Species with no ortholog for SIM2

ENSEMBL Gene Tree for SIM2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SIM2 gene

SIM1² NPAS1² NPAS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/294 NCBI SNPs in SIM2 are shown (see all 294 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 136)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2073601^1,2	A,C,F,H	37039178(+)	`GCACAC/ATGCCA`	2	M/L	mis¹ ese³		13		EU EA WA NA	1248
	rs2051397^1,2	A,C,F,H	37043407(+)	`TCCTGT/CCATGG`	1	--	ut3¹		9		EU EA WA	2336
	rs877686^1,2	A,C,F,H	37040810(-)	`AGGGGG/TCCTGG`	2	--	ng3¹ int¹		9		EA NA WA	624
	rs2073603^1,2	C,F,H	37039612(+)	`GTGATT/GTTCAA`	2	--	int¹ ut3¹		8		EA NA EU WA	2050
	rs2073417^1,2	C,F,H	37042588(+)	`CCGCTG/AGGGGA`	1	--	ut3¹ ese³		8		EU EA WA	836
	rs9982519^1,2	A,C,H	37039959(+)	`TCCTGG/CTGGCA`	2	--	ut3¹ int¹		4		EU EA WA	404
--	rs11909149^1,2	A,C	37043464(+)	`ACACTA/GTCAAC`	1	--	ut3¹ ese³		0	--	--	--	--
	rs2002799^1,2	A,F	37040577(-)	`GAGGCA/GTGGAG`	2	--	int¹ ng3¹		5		NA PA	434
	rs2845797^1,2	C	36993069(+)	`GCCGTA/GTGCAC`	2	--	ng5¹		0	--	--	--	--
--	rs9983571^1,2	A	37042419(+)	`AGGCCC/GCGCGC`	1	--	ut3¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SIM2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600892

7 Novoseek disease relationships for SIM2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	72.39	36	9199934 (3), 8812055 (3), 15946822 (3), 10400987 (2) (see all 13)
colon tumor	37.92	1	12530058 (1)
mental retardation	36.63	3	10400987 (1), 15946822 (1)
trisomy	25.91	1	10915774 (1)
solid tumor	24.39	5	12676991 (3), 17289882 (1)
cancer	0.00	3	17289882 (2), 12530058 (1)
tumors	0.00	1	14550949 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/59 PubMed articles for SIM2 gene (see all 59 ):

Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. (PubMed id 9199934)^{1, 3, 4} Chrast R.... Antonarakis S.E. (1997)
A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2. (PubMed id 14697214)^{1, 3, 4} Yamaki A.... Shimizu Y. (2004)
Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. (PubMed id 7568099)^{1, 3, 4} Dahmane N.... Delabar J.-M. (1995)
The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. (PubMed id 8661114)^{1, 3, 4} Yamaki A.... Shimizu N. (1996)
The DNA sequence of human chromosome 21. (PubMed id 10830953)^{3, 4} Hattori M....Yaspo M.L. (2000)
Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. (PubMed id 9503011)^{3, 4} Dahmane N.... Delabar J.-M. (1998)
A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region. (PubMed id 8905236)^{3, 4} Osoegawa K.... Soeda E. (1996)
Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. (PubMed id 7485157)^{2, 3} Muenke M....Fan C.M. (1995)
Single-minded and Down syndrome? (PubMed id 7647800)^{3, 4} Chen H.... Shimizu N. (1995)
Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases. (PubMed id 15963499)^{1, 3} Okui M....Shimizu Y. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6493	HGNC: 10883	AceView: SIM2	Ensembl:ENSG00000159263	euGenes: HUgn6493
ECgene: SIM2	H-InvDB: SIM2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SIM2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SIM2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SIM2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SIM2		Antibodies for SIM2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SIM2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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SIM2 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for SIM2

Summaries
for SIM2

Genomic Location
for SIM2

Proteins
for SIM2

Protein Domains/
Families
for SIM2

Gene Function
for SIM2

Pathways & Interactions
for SIM2

Drugs & Compounds
for SIM2

Transcripts
for SIM2

Expression
for SIM2

Orthologs
for SIM2

Paralogs
for SIM2

SNPs/Variants
for SIM2

Disorders & Mutations
for SIM2

Medical News
for SIM2

Publications
for SIM2

Search for SIM2

Genome Databases showing SIM2

Other Databases showing SIM2

Specialized Databases showing SIM2

Licensable Technologies
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Services
for SIM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SIM2 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor SIM2

Summariesfor SIM2

Genomic Locationfor SIM2

Proteinsfor SIM2

Protein Domains/Familiesfor SIM2

Gene Functionfor SIM2

Pathways & Interactionsfor SIM2

Drugs & Compoundsfor SIM2

Transcriptsfor SIM2

Expression for SIM2

Orthologsfor SIM2

Paralogsfor SIM2

SNPs/Variantsfor SIM2

Disorders & Mutationsfor SIM2

Medical Newsfor SIM2

Publicationsfor SIM2

Search for SIM2

Genome Databases showing SIM2

Other Databases showing SIM2

Specialized Databases showing SIM2

Licensable Technologiesfor SIM2

Servicesfor SIM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SIM2

Summaries
for SIM2

Genomic Location
for SIM2

Proteins
for SIM2

Protein Domains/
Families
for SIM2

Gene Function
for SIM2

Pathways & Interactions
for SIM2

Drugs & Compounds
for SIM2

Transcripts
for SIM2

Expression
for SIM2

Orthologs
for SIM2

Paralogs
for SIM2

SNPs/Variants
for SIM2

Disorders & Mutations
for SIM2

Medical News
for SIM2

Publications
for SIM2

Licensable Technologies
for SIM2

Services
for SIM2