SIL1 Gene
protein-coding GIFtS: 56
GCID: GC05M138282
|
|
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)(Previous name: Marinesco-Sjogren syndrome )
(Previous symbol: MSS)
| |
Aliases
for SIL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SIL1 Homolog, Endoplasmic Reticulum Chaperone (S. Cerevisiae)1 2 | | BiP-Associated Protein2 3 | | BAP1 2 3 5 | | Marinesco-Sjogren Syndrome1 | | MSS1 2 5 | | Nucleotide Exchange Factor SIL12 | | ULG51 2 | | |
Export aliases for SIL1 gene to outside databasesPrevious GC identifers: GC05M138157 GC05M138957 GC05M138313 GC05M138358 GC05M138310 GC05M133472 |
Summaries
for SIL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIL1:
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targetingsequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as anucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associatedwith Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SIL1_HUMAN, Q9H173Function: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotideexchange factor for the ER lumenal chaperone HSPA5
Gene Wiki entry for SIL1
|
Genomic Views
for SIL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIL1 gene promoter:
HOXA9 HOXA9B STAT1 POU2F1 POU2F1a Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31SIL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M138282: view genomic region
(about GC identifiers)
Start:
|
138,282,409 bp from pter |
End:
|
138,629,246 bp from pter |
Size:
|
346,838 bases |
Orientation:
|
minus strand |
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Proteins
for SIL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIL1_HUMAN, Q9H173 (See
protein sequence)Recommended Name: Nucleotide exchange factor SIL1 precursor Size: 461 amino acids; 52085 Da
Subunit: Interacts with HSPA5
Subcellular location: Endoplasmic reticulum lumen
Developmental stage: Expressed in fetal kidney, fetal lung, fetal liver and at low levels in fetal brain
Secondary accessions: D3DQC2 Q8N2L3Explore the universe of human proteins at neXtProt for SIL1: NX_Q9H173
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H173
SIL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001032722.1 NP_071909.1
ENSEMBL proteins: ENSP00000378294 ENSP00000265195 ENSP00000426858 ENSP00000425136 ENSP00000427371 ENSP00000424014 ENSP00000421890 ENSP00000426460 ENSP00000423662
Human Recombinant Protein Products for SIL1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SIL1 for ontologies About GeneDecksing
SIL1 Antibody Products:
Assay Products for SIL1: |
Protein
Domains /
Families
for SIL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H173ProtoNet protein and cluster: Q9H173 UniProtKB/Swiss-Prot: SIL1_HUMAN, Q9H173Similarity: Belongs to the SIL1 family |
Function
for SIL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SIL1_HUMAN, Q9H173Function: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotideexchange factor for the ER lumenal chaperone HSPA5 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SIL1 for ontologies About GeneDecksing
Phenotypes:
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sil1):
SIL1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SIL1 (NM_022464) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIL1 |
|
Pathways & Interactions
for SIL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SIL1):
SIL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for SIL1 (Q9H1732, 3 ENSP000002651954) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SIL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SIL1 for compounds About GeneDecksing
 Browse Tocris compounds for SIL1
4 Novoseek chemical compound relationships for SIL1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SIL1
|
Transcripts
for SIL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIL1 gene (2 alternative transcripts): NM_001037633.1 NM_022464.4 Unigene Cluster for SIL1: SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) Hs.483521 [show with all ESTs]Unigene Representative Sequence: NM_00103763315 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394817(uc003ldo.3 uc003ldp.3) ENST00000265195 ENST00000515008
ENST00000509534(uc003ldq.1) ENST00000503732 ENST00000505945 ENST00000508639
ENST00000513453 ENST00000507002 ENST00000505830 ENST00000505353 ENST00000504666
ENST00000509400 ENST00000440765 ENST00000508744
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIL1 (NM_022464) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIL1 |
Additional cDNA sequence: AF547994.1 AK074624.1 AK075177.1 AY358950.1 BC011568.1 DQ059315.1 DQ173771.1 DQ173772.1 20 DOTS entries: DT.100812066 DT.112108 DT.97771388 DT.100812072 DT.92441943 DT.100812057 DT.95355431 DT.100812062 DT.101972963 DT.95200405 DT.120805728 DT.100812069 DT.120805852 DT.100812059 DT.97846555 DT.100812060 DT.100038012 DT.120805674 DT.422080 DT.95347435 24/296 AceView cDNA sequences (see all 296): CF127079 BQ919008 BQ958936 BM906234 CR615501 CR607641 CR601222 CR617163 CF618918 BQ956450 AI685001 CK818754 AF547994 AL533390 BU681616 CR614372 BU620759 AL553490 BQ652370 BQ684380 AL545790 BM804965 CR604859 AK074624
GeneLoc Exon Structure
|
Expression
for SIL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCCGTGA
About this image
See SIL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIL1
SOURCE GeneReport for Unigene cluster: Hs.483521
UniProtKB/Swiss-Prot: SIL1_HUMAN, Q9H173Tissue specificity: Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liverand placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen andthymus. Expressed at low levels throughout the brain
SABiosciences Expression via Pathway-Focused PCR Arrays including SIL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIL1 |
Orthologs
for SIL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SIL1 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for SIL1 (if available)
TreeFam Gene Tree for SIL1 (if available) |
Paralogs
for SIL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SIL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIL1 (138282409 - 138532409 bp, first 250kb of SIL1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SIL1
2 CNVs: 22501 39434
Human Gene Mutation Database (HGMD): SIL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIL1 |
|
Disorders
/ Diseases
for SIL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIL1 for disorders About GeneDecksing
OMIM gene information: 608005
OMIM disorders: 248800
UniProtKB/Swiss-Prot: SIL1_HUMAN, Q9H173
Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS) [MIM:248800]. MSS is an autosomal recessivemultisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granulecell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal featuresinclude bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletalabnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivationof this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries thatmishandle client proteins which are critical for the organs targeted in MSS
20/27  diseases for SIL1 (see all 27): About MalaCardsmarinesco-sjogren syndrome sjogren's syndrome monoclonal gammopathy of undetermined significance renal osteodystrophy
short stature dysphagia sickle cell disease cerebellar ataxia
cataract congenital cataracts intrahepatic cholangiocarcinoma strabismus
ophthalmoplegia nystagmus multiple myeloma schistosomiasis
neurodegeneration hypogonadism myopathy cholangiocarcinoma
1 disease from the University of Copenhagen DISEASES database for SIL1:Cerebellar ataxia 8 Novoseek disease relationships for SIL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| marinesco-sjogren syndrome |
85.6 |
4 |
16282977 (3), 16282978 (1) |
| bone diseases |
59.7 |
5 |
8704118 (2), 16771240 (1) |
| renal osteodystrophy |
58.3 |
1 |
8704118 (1) |
| bone diseases metabolic |
56.8 |
1 |
8704118 (1) |
| myopathy |
50.5 |
2 |
16282977 (2) |
| cataract |
48.1 |
2 |
16282977 (2) |
| neurodegeneration |
24.4 |
1 |
16962589 (1) |
| renal failure chronic |
11 |
1 |
10354264 (1) |
GeneTests: SIL1
Marinesco-Sjogren Syndrome
Export disorders for SIL1 gene to outside databases
|
Publications
for SIL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIL1 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with SIL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in SIL1 cause Marinesco-Sjoegren syndrome, a cerebellar ataxia with cataract and myopathy. (PubMed id 16282977)1, 2, 3, 9 Senderek J.... Zerres K. (2005)
- BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. (PubMed id 12356756)1, 2, 3 Chung K.T.... Hendershot L.M. (2002)
- LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. (PubMed id 11101517)1, 2, 3 Tyson J.R. and Stirling C.J. (2000)
- The gene disrupted in Marinesco-Sjoegren syndrome encodes SIL1, an HSPA5 cochaperone. (PubMed id 16282978)1, 2, 9 Anttonen A.-K.... Lehesjoki A.-E. (2005)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Novel mutations in the SIL1 gene in a Japanese pedigr ee with the Marinesco-SjAPgren syndrome. (PubMed id 20111056)1, 9 Takahata T....Kitaoka T. (2010)
- Novel SIL1 mutations and exclusion of functional candidate genes in Marinesco-Sjogren syndrome. (PubMed id 18285827)1, 9 Anttonen A.K....Lehesjoki A.E. (2008)
- Identification of a new homozygous frameshift insertion mutation in the SIL1 gene in 3 Japanese patients with Marinesco-Sjogren syndrome. (PubMed id 18395226)1, 9 Eriguchi M....Kuroda Y. (2008)
|
External Searches for SIL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIL1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SIL1 |
|
| | |
About This Section
| Patent Information for SIL1 gene:
Search GeneIP for patents involving SIL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SIL1 | | OriGene shRNA RFP for SIL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIL1 | | | OriGene Protein Over-expression Lysate for SIL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIL1 | | OriGene 3'-UTR Clone for SIL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIL1 | | OriGene Custom Protein Services for SIL1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIL1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SIL1 |
| |  |  |  |  | | | | | | Recombinant Protein for SIL1 |
|
 |
 |
 |
 | | | SIL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIL1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SIL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIL1 |
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