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Aliases for SIKE1 Gene

Aliases for SIKE1 Gene

  • Suppressor Of IKBKE 1 2 3 5
  • Suppressor Of IKK Epsilon 2 3
  • SIKE 3 4
  • Suppressor Of IKK-Epsilon 4

External Ids for SIKE1 Gene

Previous GeneCards Identifiers for SIKE1 Gene

  • GC01M115115
  • GC01M115312
  • GC01M113170

Summaries for SIKE1 Gene

Entrez Gene Summary for SIKE1 Gene

  • SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SIKE1 Gene

SIKE1 (Suppressor Of IKBKE 1) is a Protein Coding gene. Among its related pathways are Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot for SIKE1 Gene

  • Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIKE1 Gene

Genomics for SIKE1 Gene

Regulatory Elements for SIKE1 Gene

Enhancers for SIKE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F114754 0.8 ENCODE 36.1 +23.9 23902 4.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SIKE1 OLFML3 RSBN1 TRIM33 NGF ENSG00000228035 TSPAN2 CSDE1 GC01M114751 PIR52575
GH01F113927 1.2 FANTOM5 ENCODE 21.8 +848.8 848779 8.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TRIM33 LOC100421402 LRIG2 OLFML3 RSBN1 SIKE1 DCLRE1B AP4B1 AP4B1-AS1 HIPK1
GH01F114715 0.4 ENCODE 21.2 +64.2 64246 2.4 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 YY1 RSBN1 TRIM33 OLFML3 SIKE1 NGF DENND2C CSDE1 ENSG00000228035 TSPAN2 NRAS
GH01F114508 1 FANTOM5 ENCODE 13.1 +269.6 269598 4.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 TRIM33 SIKE1 AP4B1 OLFML3 RSBN1 TSHB BCAS2 ENSG00000201114
GH01F115301 1.3 Ensembl ENCODE 13.1 -522.0 -521983 1.9 ZNF791 TARDBP BHLHE40 IKZF1 CEBPB YBX1 PRDM1 SIKE1 TRIM33 NGF ENSG00000228035
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIKE1 on UCSC Golden Path with GeneCards custom track

Promoters for SIKE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000543063 287 2000 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for SIKE1 Gene

Chromosome:
1
Start:
114,769,479 bp from pter
End:
114,780,687 bp from pter
Size:
11,209 bases
Orientation:
Minus strand

Genomic View for SIKE1 Gene

Genes around SIKE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIKE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIKE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIKE1 Gene

Proteins for SIKE1 Gene

  • Protein details for SIKE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRV8-SIKE1_HUMAN
    Recommended name:
    Suppressor of IKBKE 1
    Protein Accession:
    Q9BRV8
    Secondary Accessions:
    • Q5TEZ7
    • Q5TEZ9
    • Q68DZ4
    • Q9H778

    Protein attributes for SIKE1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23721 Da
    Quaternary structure:
    • Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation (PubMed:16281057). Interacts with CDC42BPB (PubMed:25743393).
    SequenceCaution:
    • Sequence=CAI18824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SIKE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIKE1 Gene

Post-translational modifications for SIKE1 Gene

  • Ubiquitination at Lys 154
  • Modification sites at PhosphoSitePlus

Other Protein References for SIKE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIKE1 Gene

Domains & Families for SIKE1 Gene

Gene Families for SIKE1 Gene

Protein Domains for SIKE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SIKE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRV8

UniProtKB/Swiss-Prot:

SIKE1_HUMAN :
  • Belongs to the SIKE family.
Family:
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with SIKE1: view

Function for SIKE1 Gene

Molecular function for SIKE1 Gene

UniProtKB/Swiss-Prot Function:
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Gene Ontology (GO) - Molecular Function for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
genes like me logo Genes that share ontologies with SIKE1: view

Phenotypes for SIKE1 Gene

GenomeRNAi human phenotypes for SIKE1:
genes like me logo Genes that share phenotypes with SIKE1: view

Animal Model Products

miRNA for SIKE1 Gene

miRTarBase miRNAs that target SIKE1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIKE1 Gene

Localization for SIKE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIKE1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIKE1 Gene COMPARTMENTS Subcellular localization image for SIKE1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SIKE1: view

Pathways & Interactions for SIKE1 Gene

genes like me logo Genes that share pathways with SIKE1: view

Gene Ontology (GO) - Biological Process for SIKE1 Gene

None

No data available for SIGNOR curated interactions for SIKE1 Gene

Transcripts for SIKE1 Gene

Unigene Clusters for SIKE1 Gene

Suppressor of IKBKE 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for SIKE1 Gene

GeneLoc Exon Structure for
SIKE1
ECgene alternative splicing isoforms for
SIKE1

Expression for SIKE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIKE1 Gene

Protein differential expression in normal tissues from HIPED for SIKE1 Gene

This gene is overexpressed in Plasma (17.0), Peripheral blood mononuclear cells (14.8), Pancreatic juice (10.4), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIKE1 Gene



Protein tissue co-expression partners for SIKE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIKE1 Gene:

SIKE1

SOURCE GeneReport for Unigene cluster for SIKE1 Gene:

Hs.709277

mRNA Expression by UniProt/SwissProt for SIKE1 Gene:

Q9BRV8-SIKE1_HUMAN
Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
genes like me logo Genes that share expression patterns with SIKE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SIKE1 Gene

Orthologs for SIKE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIKE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIKE1 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia SIKE1 34 35
  • 94.47 (n)
cow
(Bos Taurus)
Mammalia SIKE1 34 35
  • 94.36 (n)
oppossum
(Monodelphis domestica)
Mammalia SIKE1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIKE1 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sike1 34
  • 86.96 (n)
mouse
(Mus musculus)
Mammalia Sike1 34 16 35
  • 86.8 (n)
chicken
(Gallus gallus)
Aves SIKE1 34 35
  • 70.57 (n)
lizard
(Anolis carolinensis)
Reptilia SIKE1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sike1 34
  • 68.01 (n)
Str.10737 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12065 34
zebrafish
(Danio rerio)
Actinopterygii LOC568173 34
  • 62.94 (n)
SIKE1 35
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10158 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 35
  • 29 (a)
OneToMany
Species where no ortholog for SIKE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIKE1 Gene

ENSEMBL:
Gene Tree for SIKE1 (if available)
TreeFam:
Gene Tree for SIKE1 (if available)

Paralogs for SIKE1 Gene

Paralogs for SIKE1 Gene

(1) SIMAP similar genes for SIKE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SIKE1: view

Variants for SIKE1 Gene

Sequence variations from dbSNP and Humsavar for SIKE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111462321 -- 114,777,337(+) TTTTT(A/T)AAAAT intron-variant
rs111665907 -- 114,777,084(+) CATCA(C/T)ACACC intron-variant
rs111973742 -- 114,776,814(+) TATTG(C/T)GGCAC intron-variant
rs113509654 -- 114,776,662(+) TTTTC(-/C)TTTCA intron-variant
rs113566211 -- 114,776,728(+) TACCA(C/T)TTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIKE1 Gene

Variant ID Type Subtype PubMed ID
esv2716496 CNV deletion 23290073
esv2716507 CNV deletion 23290073
esv2716518 CNV deletion 23290073
esv28734 CNV loss 19812545
esv3587275 CNV loss 21293372
nsv824265 CNV gain 20364138

Variation tolerance for SIKE1 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIKE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIKE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIKE1 Gene

Disorders for SIKE1 Gene

Relevant External Links for SIKE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIKE1

No disorders were found for SIKE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIKE1 Gene

Publications for SIKE1 Gene

  1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PMID: 16281057) Huang J. … Shu H.-B. (EMBO J. 2005) 2 3 4 22 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. (PMID: 25743393) Lant B. … Derry W.B. (Nat. Commun. 2015) 4 64
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3 64

Products for SIKE1 Gene

Sources for SIKE1 Gene

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