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Aliases for SIKE1 Gene

Aliases for SIKE1 Gene

  • Suppressor Of IKBKE 1 2 3
  • SIKE 3 4 6
  • Suppressor Of IKK Epsilon 2 3
  • Suppressor Of IKK-Epsilon 3 4

External Ids for SIKE1 Gene

Summaries for SIKE1 Gene

Entrez Gene Summary for SIKE1 Gene

  • SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SIKE1 Gene

SIKE1 (Suppressor Of IKBKE 1) is a Protein Coding gene. Diseases associated with SIKE1 include cavernous malformation. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot for SIKE1 Gene

  • Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIKE1 Gene

Genomics for SIKE1 Gene

Genomic Location for SIKE1 Gene

Start:
114,769,479 bp from pter
End:
114,780,687 bp from pter
Size:
11,209 bases
Orientation:
Minus strand

Genomic View for SIKE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIKE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIKE1 Gene

No data available for Regulatory Elements for SIKE1 Gene

Proteins for SIKE1 Gene

  • Protein details for SIKE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRV8-SIKE1_HUMAN
    Recommended name:
    Suppressor of IKBKE 1
    Protein Accession:
    Q9BRV8
    Secondary Accessions:
    • Q5TEZ7
    • Q5TEZ9
    • Q68DZ4
    • Q9H778

    Protein attributes for SIKE1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23721 Da
    Quaternary structure:
    • Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation.
    SequenceCaution:
    • Sequence=CAI18824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SIKE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIKE1 Gene

Proteomics data for SIKE1 Gene at MOPED

Post-translational modifications for SIKE1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys154

Other Protein References for SIKE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SIKE1 Gene

Domains for SIKE1 Gene

Protein Domains for SIKE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SIKE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRV8

UniProtKB/Swiss-Prot:

SIKE1_HUMAN
Family:
  • Belongs to the SIKE family.:
    • Q9BRV8
genes like me logo Genes that share domains with SIKE1: view

No data available for Gene Families for SIKE1 Gene

Function for SIKE1 Gene

Molecular function for SIKE1 Gene

UniProtKB/Swiss-Prot Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Gene Ontology (GO) - Molecular Function for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
genes like me logo Genes that share ontologies with SIKE1: view

miRNA for SIKE1 Gene

miRTarBase miRNAs that target SIKE1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIKE1 Gene

Localization for SIKE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIKE1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIKE1 Gene COMPARTMENTS Subcellular localization image for SIKE1 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SIKE1: view

Pathways for SIKE1 Gene

genes like me logo Genes that share pathways with SIKE1: view

Gene Ontology (GO) - Biological Process for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIKE1: view

Transcripts for SIKE1 Gene

Unigene Clusters for SIKE1 Gene

Suppressor of IKBKE 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for SIKE1 Gene

GeneLoc Exon Structure for
SIKE1
ECgene alternative splicing isoforms for
SIKE1

Expression for SIKE1 Gene

mRNA expression in normal human tissues for SIKE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIKE1 Gene

SOURCE GeneReport for Unigene cluster for SIKE1 Gene Hs.709277

mRNA Expression by UniProt/SwissProt for SIKE1 Gene

Q9BRV8-SIKE1_HUMAN
Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
genes like me logo Genes that share expressions with SIKE1: view

No data available for mRNA differential expression in normal tissues for SIKE1 Gene

Orthologs for SIKE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIKE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIKE1 35
  • 99.36 (n)
  • 100 (a)
SIKE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIKE1 35
  • 94.36 (n)
  • 95.65 (a)
SIKE1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIKE1 35
  • 94.47 (n)
  • 97.63 (a)
SIKE1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sike1 35
  • 86.8 (n)
  • 91.79 (a)
Sike1 16
Sike1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIKE1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIKE1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sike1 35
  • 86.96 (n)
  • 90.82 (a)
chicken
(Gallus gallus)
Aves SIKE1 35
  • 70.57 (n)
  • 74.63 (a)
SIKE1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIKE1 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12065 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sike1 35
  • 68.01 (n)
  • 69.7 (a)
Str.10737 35
zebrafish
(Danio rerio)
Actinopterygii LOC568173 35
  • 62.94 (n)
  • 60.19 (a)
SIKE1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10158 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 36
  • 29 (a)
OneToMany
Species with no ortholog for SIKE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIKE1 Gene

ENSEMBL:
Gene Tree for SIKE1 (if available)
TreeFam:
Gene Tree for SIKE1 (if available)

Paralogs for SIKE1 Gene

Paralogs for SIKE1 Gene

Selected SIMAP similar genes for SIKE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SIKE1: view

Variants for SIKE1 Gene

Sequence variations from dbSNP and Humsavar for SIKE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3827739 -- 114,773,537(-) ATACT(A/G)AAAGT utr-variant-3-prime, nc-transcript-variant
rs3933224 -- 114,775,607(-) atcac(C/T)tgaac intron-variant
rs4603134 -- 114,777,143(+) AATAC(C/T)TAATG intron-variant
rs4839390 -- 114,770,251(+) aatta(A/G)ctgtg utr-variant-3-prime, nc-transcript-variant
rs6683934 -- 114,779,000(+) tgcag(C/T)gagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIKE1 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv824265 CNV Gain 20364138
esv2716496 CNV Deletion 23290073
esv2716507 CNV Deletion 23290073
esv2716518 CNV Deletion 23290073

Relevant External Links for SIKE1 Gene

HapMap Linkage Disequilibrium report
SIKE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIKE1 Gene

Disorders for SIKE1 Gene

(1) MalaCards Diseases for SIKE1 Gene

Search for SIKE1 Gene in MalaCards »
genes like me logo Genes that share disorders with SIKE1: view

No data available for UniProtKB/Swiss-Prot for SIKE1 Gene

Publications for SIKE1 Gene

  1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PMID: 16281057) Huang J. … Shu H.-B. (EMBO J. 2005) 2 3 4 23
  2. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PMID: 17620012) Holaska J.M. … Wilson K.L. (Biochemistry 2007) 3

Products for SIKE1 Gene

Sources for SIKE1 Gene

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