SIKE1 Gene
protein-coding GIFtS: 50
GCID: GC01M115312
|
|
suppressor of IKBKE 1
| |
Aliases
for SIKE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Suppressor Of IKBKE 11 2 | | SIKE1 2 3 5 | | Suppressor Of IKK-Epsilon2 3 | | FLJ211681 | | Suppressor Of IKK Epsilon2 |
Export aliases for SIKE1 gene to outside databasesPrevious GC identifers: GC01M115115 GC01M113170 |
Summaries
for SIKE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIKE1:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029)and virus-triggered interferon activation pathways (Huang et al., 2005 (PubMed 16281057)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggeredIRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter.May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibitNF-kappa-B activation pathways
|
Genomic Views
for SIKE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SIKE1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIKE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIKE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1SIKE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M115312: view genomic region
(about GC identifiers)
Start:
|
115,312,100 bp from pter |
End:
|
115,323,308 bp from pter |
Size:
|
11,209 bases |
Orientation:
|
minus strand |
|
Proteins
for SIKE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8 (See
protein sequence)Recommended Name: Suppressor of IKBKE 1 Size: 207 amino acids; 23721 Da
Subunit: Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viralinfection or TLR3 stimulation
Subcellular location: Cytoplasm
Sequence caution: Sequence=CAI18824.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TEZ7 Q5TEZ9 Q68DZ4 Q9H778Alternative splicing: 2 isoforms: Q9BRV8-1 Q9BRV8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIKE1: NX_Q9BRV8
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRV8
SIKE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001095866.1 NP_079349.2
ENSEMBL proteins: ENSP00000358541 ENSP00000060969 Reactome Protein details: Q9BRV8
Human Recombinant Protein Products for SIKE1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SIKE1 for ontologies About GeneDecksing
SIKE1 Antibody Products:
Assay Products for SIKE1: |
Protein
Domains /
Families
for SIKE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIKE1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRV8ProtoNet protein and cluster: Q9BRV8 UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8Similarity: Belongs to the SIKE family |
Function
for SIKE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SIKE1_HUMAN, Q9BRV8Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggeredIRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter.May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibitNF-kappa-B activation pathways Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SIKE1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SIKE1 (NM_025073) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIKE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIKE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1 |
|
Pathways & Interactions
for SIKE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 3 | Regulation of IFNA signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for SIKE1
1 
Kegg Pathway (Kegg details for SIKE1):
SIKE1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIKE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/63 Interacting proteins for SIKE1 (Q9BRV81, 3 ENSP000003585414) via UniProtKB, MINT, STRING, and/or I2D (see all 63)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045087 | innate immune response |
TAS | -- |
SIKE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIKE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIKE1
Search CenterWatch for drugs/clinical trials and news about SIKE1
|
Transcripts
for SIKE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIKE1 gene (2 alternative transcripts): NM_001102396.1 NM_025073.2 Unigene Cluster for SIKE1: Suppressor of IKBKE 1 Hs.709277 [show with all ESTs]Unigene Representative Sequence: NR_04974110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369528(uc001efp.4 uc001efo.4) ENST00000060969 ENST00000369524
ENST00000510745 ENST00000506320 ENST00000462123 ENST00000475335 ENST00000466657
ENST00000474562 ENST00000471969
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIKE1 (NM_025073) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIKE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIKE1 |
Additional cDNA sequence: AK024821.1 AK126316.1 AK225734.1 BC005934.1 CR749219.1 CR936771.1 NR_049741.1 NR_049742.1 15 DOTS entries: DT.214929 DT.40112505 DT.86854234 DT.100778914 DT.121460029 DT.97803977 DT.100778912 DT.102827710 DT.121459977 DT.95354873 DT.95369448 DT.92474308 DT.95153503 DT.95354872 DT.97860950 24/114 AceView cDNA sequences (see all 114): AI597764 NM_025073 CA445174 AA169202 BU857202 AK024821 AA041325 T07199 BM464113 AA489467 AI913267 AI215797 AK126316 AA768734 R69838 AA836394 BX119268 BX489737 BF439386 AI983535 BU538394 BU625382 AA165333 BQ961602
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIKE1
|
Expression
for SIKE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIKE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTAGAAT
About this image
See SIKE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIKE1
SOURCE GeneReport for Unigene cluster: Hs.709277
UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver,small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level)
SABiosciences Custom PCR Arrays for SIKE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIKE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIKE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIKE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIKE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1 |
Orthologs
for SIKE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SIKE1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SIKE11 |
suppressor of IKBKE 1 |
70.51(n)
74.36(a) |
|
419887 NM_001006324.1 NP_001006324.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SIKE16 |
-- |
67(a) |
1 ↔ 1 |
4(130445325-130448476) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.120652 |
Xenopus laevis transcribed sequence with weak similarity more |
72.82(n) |
|
CD326326.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5681731 |
suppressor of IKBKE 1-like |
62.8(n)
59.9(a) |
|
568173 XM_691486.2 XP_696578.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG101586 |
-- |
19(a) |
1 → many |
2L(6943178-6945289) |
ENSEMBL Gene Tree for SIKE1 (if available)
TreeFam Gene Tree for SIKE1 (if available) |
Paralogs
for SIKE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIKE1 gene
- FGFR1OP22
1 SIMAP similar gene for SIKE1 using alignment to 1 protein entry: SIKE1_HUMAN:FGFR1OP2
SIKE1 for paralogs About GeneDecksing
|
Genomic Variants
for SIKE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIKE1 (115312100 - 115323308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SIKE1
3 CNVs: 2322 3306 64651 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SIKE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIKE1 for disorders About GeneDecksing
OMIM gene information: 611656
OMIM disorders: --
4  diseases for SIKE1: About MalaCardscerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 cerebritis
Export disorders for SIKE1 gene to outside databases
|
Publications
for SIKE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIKE1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SIKE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 3, 9 Huang J.... Shu H.-B. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
- A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1 Goudreault M....Gingras A.C. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for SIKE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIKE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIKE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIKE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIKE1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SIKE1 gene:
Search GeneIP for patents involving SIKE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIKE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIKE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIKE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIKE1 | | | OriGene Protein Over-expression Lysate for SIKE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIKE1 | | OriGene 3'-UTR Clone for SIKE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIKE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIKE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIKE1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIKE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIKE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIKE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIKE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIKE1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SIKE1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SIKE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SIKE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIKE1 |
| |  | |
|
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