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SIKE1 Gene

protein-coding   GIFtS: 50
GCID: GC01M115312

Suppressor Of IKBKE 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor Of IKBKE 11 2
SIKE2 3 5
Suppressor Of IKK Epsilon1 2
Suppressor Of IKK-Epsilon2 3

External Ids:    HGNC: 261191   Entrez Gene: 801432   Ensembl: ENSG000000527237   OMIM: 6116565   UniProtKB: Q9BRV83   

Export aliases for SIKE1 gene to outside databases

Previous GC identifers: GC01M115115 GC01M113170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIKE1 Gene:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM
603029) and virus-triggered interferon activation pathways (Huang et al., 2005 (PubMed 16281057)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for SIKE1 Gene:
SIKE1 (suppressor of IKBKE 1) is a protein-coding gene. Diseases associated with SIKE1 include cerebral cavernous malformations 3, and cavernous malformation. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and
TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the
IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and
DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SIKE1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SIKE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIKE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

SIKE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIKE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115312:  view genomic region     (about GC identifiers)

Start:
115,312,100 bp from pter      End:
115,323,308 bp from pter
Size:
11,209 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8 (See protein sequence)
Recommended Name: Suppressor of IKBKE 1  
Size: 207 amino acids; 23721 Da
Subunit: Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral
infection or TLR3 stimulation
Sequence caution: Sequence=CAI18824.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TEZ7 Q5TEZ9 Q68DZ4 Q9H778
Alternative splicing: 2 isoforms:  Q9BRV8-1   Q9BRV8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIKE1: NX_Q9BRV8

Explore proteomics data for SIKE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys154
  • Modification sites at PhosphoSitePlus

  • See SIKE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001095866.1  NP_079349.2  

    ENSEMBL proteins: 
     ENSP00000358541   ENSP00000060969  
    Reactome Protein details: Q9BRV8

    SIKE1 Human Recombinant Protein Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008555 SIKE

    Graphical View of Domain Structure for InterPro Entry Q9BRV8

    ProtoNet protein and cluster: Q9BRV8

    UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
    Similarity: Belongs to the SIKE family


    SIKE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIKE1_HUMAN, Q9BRV8
    Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and
    TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the
    IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and
    DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18782753
         
    SIKE1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIKE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIKE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIKE1

    miRNA
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    miRTarBase miRNAs that target SIKE1:
    hsa-let-7b-5p (MIRT052225)

    Block miRNA regulation of human, mouse, rat SIKE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIKE1 (see all 56):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-429 hsa-miR-106a hsa-miR-29a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIKE1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIKE1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIKE1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIKE1_HUMAN, Q9BRV8: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion ----
    GO:0043231intracellular membrane-bounded organelle ----

    SIKE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIKE1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SIKE1
        TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation


    1 Kegg Pathway  (Kegg details for SIKE1):
        RIG-I-like receptor signaling pathway


    SIKE1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIKE1
    Interactions:

        Search GeneGlobe Interaction Network for SIKE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIKE1 (Q9BRV81, 3 ENSP000003585414) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1773646,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    FGFR1OP2Q9NVK53, ENSP000002293954I2D: score=2 STRING: ENSP00000229395
    MOB4Q9Y3A33, ENSP000003157024I2D: score=2 STRING: ENSP00000315702
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    SLMAPQ14BN43, ENSP000002959514I2D: score=2 STRING: ENSP00000295951
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response TAS--

    SIKE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIKE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIKE1 gene (2 alternative transcripts): 
    NM_001102396.1  NM_025073.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369528(uc001efp.4 uc001efo.4) ENST00000060969 ENST00000369524
    ENST00000510745 ENST00000506320 ENST00000462123 ENST00000475335 ENST00000466657
    ENST00000474562 ENST00000471969
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIKE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIKE1 (see all 56):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-429 hsa-miR-106a hsa-miR-29a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIKE1
    Clone
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    OriGene ORF clones in mouse, rat for SIKE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SIKE1 (NM_025073)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIKE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIKE1
    Primer
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    OriGene qPCR primer pairs and template standards for SIKE1
    OriGene qSTAR qPCR primer pairs in human, mouse for SIKE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIKE1
      QuantiTect SYBR Green Assays in human, mouse, rat SIKE1
      QuantiFast Probe-based Assays in human, mouse, rat SIKE1

    Selected AceView cDNA sequences (see all 114):

    BU857202 AI215797 AI597764 AA165333 AA041325 BQ961602 BU625382 AA489467 
    AK024821 AA836394 AA169202 CA445174 BM464113 AI983535 R69838 AA768734 
    AK126316 BU538394 AI913267 BF439386 BX119268 NM_025073 BX489737 T07199 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                -     -                 -     -                                 
    SP2:                                      -                 -     -                                 
    SP3:                                -     -     -           -     -                                 
    SP4:                                                        -     -                                 
    SP5:                                -     -                                                         


    ECgene alternative splicing isoforms for SIKE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIKE1 expression in normal human tissues (normalized intensities)      SIKE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTAGAAT
    SIKE1 Expression
    About this image


    SIKE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SIKE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIKE1 Protein Expression

    UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
    Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney,
    liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat SIKE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SIKE1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sike11 , 5 suppressor of IKBKE 11, 5 86.8(n)1
    91.79(a)1
      3 (45.25 cM)5
    666411  NM_025679.31  NP_079955.11 
     1029957285 
    chicken
    (Gallus gallus)
    Aves SIKE11 suppressor of IKBKE 1 70.57(n)
    74.63(a)
      419887  NM_001006324.2  NP_001006324.2 
    lizard
    (Anolis carolinensis)
    Reptilia SIKE16
    suppressor of IKBKE 1
    67(a)
    1 ↔ 1
    4(130445325-130452152)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120652 Xenopus laevis transcribed sequence with weak similarity more 72.82(n)    CD326326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5681731 suppressor of IKBKE 1-like 62.94(n)
    60.19(a)
      568173  XM_005174135.1  XP_005174192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101586
    --
    18(a)
    1 → many
    2L(6943178-6945289)


    ENSEMBL Gene Tree for SIKE1 (if available)
    TreeFam Gene Tree for SIKE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIKE1 gene
    FGFR1OP22  
    1 SIMAP similar gene for SIKE1 using alignment to 1 protein entry:     SIKE1_HUMAN:
    FGFR1OP2

    SIKE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIKE1 (see all 215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812610741,2
    C--115311605(+) TCACAC/TGGTCC 4 -- ds5001 int10--------
    rs1849499871,2
    --115311966(+) CTCTGA/TAAGTT 4 -- ds5001 int10--------
    rs1384745071,2
    --115312056(+) GACACA/TGGAAG 4 -- ds5001 int10--------
    rs1411650671,2
    --115312130(+) TATATA/GTGTAT 4 -- ut31 nc-transcript-variant0--------
    rs1507148041,2
    C--115312254(+) CAAATC/TCTTAG 4 -- ut31 nc-transcript-variant0--------
    rs1378684251,2
    --115312395(+) GGGGTC/TGGCAA 4 -- ut31 nc-transcript-variant0--------
    rs1494894251,2
    --115312909(+) GCGACA/TTGGGA 4 -- ut31 nc-transcript-variant0--------
    rs1880950891,2
    --115312927(+) GCAGGA/TGAATC 4 -- ut31 nc-transcript-variant0--------
    rs1471535811,2
    --115312986(+) GCACTA/CCAGCC 4 -- ut31 nc-transcript-variant0--------
    rs607629791,2
    C--115313028(+) AAAAA-/ATAGAA 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SIKE1 (115312100 - 115323308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SIKE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716496CNV Deletion23290073
    esv2716507CNV Deletion23290073
    esv2716518CNV Deletion23290073
    esv28734CNV Loss19812545
    nsv824265CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SIKE1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIKE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611656    OMIM disorders: --

    8 diseases for SIKE1:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis
    tonsillitis    thyroiditis    endotheliitis    prostatitis


    SIKE1 for disorders           About GeneDecksing


    Export disorders for SIKE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIKE1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SIKE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 3, 9 Huang J.... Shu H.-B. (EMBO J. 2005)
    2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    5. Mechanism of endogenous regulation of the type I interferon response by suppressor of II_B kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1). (PubMed id 23649622)1 Marion J.D....Bell J.K. (J. Biol. Chem. 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (Mol. Syst. Biol. 2009)
    8. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. An emerin &quot;proteome&quot;: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (Biochemistry 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80143 HGNC: 26119 AceView: FLJ21168 Ensembl:ENSG00000052723 euGenes: HUgn80143
    ECgene: SIKE1 Kegg: 80143 H-InvDB: SIKE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIKE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIKE1 gene:
    Search GeneIP for patents involving SIKE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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