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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIKE1 Gene

protein-coding   GIFtS: 50
GCID: GC01M115312

Suppressor Of IKBKE 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Suppressor Of IKBKE 11 2
SIKE2 3 5
Suppressor Of IKK Epsilon1 2
Suppressor Of IKK-Epsilon2 3

External Ids:    HGNC: 261191   Entrez Gene: 801432   Ensembl: ENSG000000527237   OMIM: 6116565   UniProtKB: Q9BRV83   

Export aliases for SIKE1 gene to outside databases

Previous GC identifers: GC01M115115 GC01M113170


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIKE1 Gene:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM
603029) and virus-triggered interferon activation pathways (Huang et al., 2005 (PubMed 16281057)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for SIKE1 Gene: 
SIKE1 (suppressor of IKBKE 1) is a protein-coding gene. Diseases associated with SIKE1 include cerebral cavernous malformations 3, and cavernous malformation, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Immune System. GO annotations related to this gene include protein binding. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and
TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the
IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and
DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SIKE1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SIKE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIKE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

SIKE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIKE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115312:  view genomic region     (about GC identifiers)

Start:
115,312,100 bp from pter      End:
115,323,308 bp from pter
Size:
11,209 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8 (See protein sequence)
Recommended Name: Suppressor of IKBKE 1  
Size: 207 amino acids; 23721 Da
Subunit: Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral
infection or TLR3 stimulation
Subcellular location: Cytoplasm
Sequence caution: Sequence=CAI18824.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TEZ7 Q5TEZ9 Q68DZ4 Q9H778
Alternative splicing: 2 isoforms:  Q9BRV8-1   Q9BRV8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIKE1: NX_Q9BRV8

Explore proteomics data for SIKE1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRV8

  • SIKE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIKE1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001095866.1  NP_079349.2  

    ENSEMBL proteins: 
     ENSP00000358541   ENSP00000060969  
    Reactome Protein details: Q9BRV8
    Human Recombinant Protein Products for SIKE1: 
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    Novus Biologicals SIKE1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    SIKE1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008555 SIKE

    Graphical View of Domain Structure for InterPro Entry Q9BRV8

    ProtoNet protein and cluster: Q9BRV8

    UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
    Similarity: Belongs to the SIKE family


    SIKE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIKE1_HUMAN, Q9BRV8
    Function: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and
    TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the
    IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and
    DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18782753
         
    SIKE1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIKE1 
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    hsa-miR-21* hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-429 hsa-miR-106a hsa-miR-29a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIKE1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3TRAF6 mediated IRF7 activation
    TRAF6 mediated IRF7 activation0.45
    TRAF3-dependent IRF activation pathway0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SIKE1
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for SIKE1):
        RIG-I-like receptor signaling pathway


    SIKE1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIKE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for SIKE1 (Q9BRV81, 3 ENSP000003585414) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF3IP3Q9Y2281, 3, ENSP000000103384EBI-1773646,EBI-765817 I2D: score=2 STRING: ENSP00000010338
    FGFR1OP2Q9NVK53, ENSP000002293954I2D: score=2 STRING: ENSP00000229395
    MOB4Q9Y3A33, ENSP000003157024I2D: score=2 STRING: ENSP00000315702
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    SLMAPQ14BN43, ENSP000002959514I2D: score=2 STRING: ENSP00000295951
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response TAS--

    SIKE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIKE1

    Search CenterWatch for drugs/clinical trials and news about SIKE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIKE1 gene (2 alternative transcripts): 
    NM_001102396.1  NM_025073.2  

    Unigene Cluster for SIKE1:

    Suppressor of IKBKE 1
    Hs.709277  [show with all ESTs]
    Unigene Representative Sequence: NR_049741
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369528(uc001efp.4 uc001efo.4) ENST00000060969 ENST00000369524
    ENST00000510745 ENST00000506320 ENST00000462123 ENST00000475335 ENST00000466657
    ENST00000474562 ENST00000471969
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SIKE1 (see all 56):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-429 hsa-miR-106a hsa-miR-29a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AK024821.1 AK126316.1 AK225734.1 BC005934.1 CR749219.1 CR936771.1 NR_049741.1 NR_049742.1 

    15 DOTS entries:

    DT.214929  DT.40112505  DT.86854234  DT.100778914  DT.121460029  DT.97803977  DT.100778912  DT.102827710 
    DT.121459977  DT.95354873  DT.95369448  DT.92474308  DT.95153503  DT.95354872  DT.97860950 

    24/114 AceView cDNA sequences (see all 114):

    BU625382 AA489467 AA836394 AI215797 BU538394 BQ961602 NM_025073 AI913267 
    T07199 AA165333 CA445174 BX119268 BX489737 BU857202 BM464113 AI983535 
    AA041325 AA169202 BF439386 R69838 AK126316 AA768734 AI597764 AK024821 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                                -     -                 -     -                                 
    SP2:                                      -                 -     -                                 
    SP3:                                -     -     -           -     -                                 
    SP4:                                                        -     -                                 
    SP5:                                -     -                                                         


    ECgene alternative splicing isoforms for SIKE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIKE1 expression in normal human tissues (normalized intensities)      SIKE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTAGAAT
    SIKE1 Expression
    About this image


    SIKE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             skeletal muscle ; myocytes   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See SIKE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIKE1

    SOURCE GeneReport for Unigene cluster: Hs.709277

    UniProtKB/Swiss-Prot: SIKE1_HUMAN, Q9BRV8
    Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney,
    liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIKE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SIKE1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sike11 , 5 suppressor of IKBKE 11, 5 86.8(n)1
    91.79(a)1
      3 (45.25 cM)5
    666411  NM_025679.31  NP_079955.11 
     1029957285 
    chicken
    (Gallus gallus)
    Aves SIKE11 suppressor of IKBKE 1 70.51(n)
    74.36(a)
      419887  NM_001006324.1  NP_001006324.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIKE16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    4(130445325-130452152)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120652 Xenopus laevis transcribed sequence with weak similarity more 72.82(n)    CD326326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5681731 suppressor of IKBKE 1-like 62.8(n)
    59.9(a)
      568173  XM_691486.2  XP_696578.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101586
    --
    17(a)
    1 → many
    2L(6943178-6945289)


    ENSEMBL Gene Tree for SIKE1 (if available)
    TreeFam Gene Tree for SIKE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIKE1 gene
    FGFR1OP22  
    1 SIMAP similar gene for SIKE1 using alignment to 1 protein entry:     SIKE1_HUMAN:
    FGFR1OP2

    SIKE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 SNPs in SIKE1 are shown (see all 215)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1812610741,2
    C--115311605(+) TCACAC/TGGTCC 4 -- ds5001 int10--------
    rs1849499871,2
    --115311966(+) CTCTGA/TAAGTT 4 -- ds5001 int10--------
    rs1384745071,2
    --115312056(+) GACACA/TGGAAG 4 -- ds5001 int10--------
    rs1411650671,2
    --115312130(+) TATATA/GTGTAT 4 -- ut31 nc-transcript-variant0--------
    rs1507148041,2
    C--115312254(+) CAAATC/TCTTAG 4 -- ut31 nc-transcript-variant0--------
    rs1378684251,2
    --115312395(+) GGGGTC/TGGCAA 4 -- ut31 nc-transcript-variant0--------
    rs1494894251,2
    --115312909(+) GCGACA/TTGGGA 4 -- ut31 nc-transcript-variant0--------
    rs1880950891,2
    --115312927(+) GCAGGA/TGAATC 4 -- ut31 nc-transcript-variant0--------
    rs1471535811,2
    --115312986(+) GCACTA/CCAGCC 4 -- ut31 nc-transcript-variant0--------
    rs607629791,2
    C--115313028(+) AAAAA-/ATAGAA 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for SIKE1 (115312100 - 115323308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SIKE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716496CNV Deletion23290073
    esv2716507CNV Deletion23290073
    esv2716518CNV Deletion23290073
    esv28734CNV Loss19812545
    nsv824265CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611656    OMIM disorders: --

    4 diseases for SIKE1:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    cerebritis


    SIKE1 for disorders           About GeneDecksing


    Export disorders for SIKE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIKE1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SIKE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 3, 9 Huang J.... Shu H.-B. (2005)
    2. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    3. Mechanism of endogenous regulation of the type I inter feron response by suppressor of IkB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1). (PubMed id 23649622)1 Marion J.D....Bell J.K. (2013)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (2009)
    6. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1 Goudreault M....Gingras A.C. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80143 HGNC: 26119 AceView: FLJ21168 Ensembl:ENSG00000052723 euGenes: HUgn80143
    ECgene: SIKE1 Kegg: 80143 H-InvDB: SIKE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIKE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIKE1 gene:
    Search GeneIP for patents involving SIKE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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