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Aliases for SIKE1 Gene

Aliases for SIKE1 Gene

  • Suppressor Of IKBKE 1 2 3 5
  • Suppressor Of IKK Epsilon 2 3
  • Suppressor Of IKK-Epsilon 3 4
  • SIKE 3 4

External Ids for SIKE1 Gene

Previous GeneCards Identifiers for SIKE1 Gene

  • GC01M115115
  • GC01M115312
  • GC01M113170

Summaries for SIKE1 Gene

Entrez Gene Summary for SIKE1 Gene

  • SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SIKE1 Gene

SIKE1 (Suppressor Of IKBKE 1) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Immune System. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot for SIKE1 Gene

  • Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIKE1 Gene

Genomics for SIKE1 Gene

Regulatory Elements for SIKE1 Gene

Enhancers for SIKE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIKE1 on UCSC Golden Path with GeneCards custom track

Promoters for SIKE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIKE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIKE1 Gene

114,769,479 bp from pter
114,780,687 bp from pter
11,209 bases
Minus strand

Genomic View for SIKE1 Gene

Genes around SIKE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIKE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIKE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIKE1 Gene

Proteins for SIKE1 Gene

  • Protein details for SIKE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Suppressor of IKBKE 1
    Protein Accession:
    Secondary Accessions:
    • Q5TEZ7
    • Q5TEZ9
    • Q68DZ4
    • Q9H778

    Protein attributes for SIKE1 Gene

    207 amino acids
    Molecular mass:
    23721 Da
    Quaternary structure:
    • Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation (PubMed:16281057). Interacts with CDC42BPB (PubMed:25743393).
    • Sequence=CAI18824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SIKE1 Gene


neXtProt entry for SIKE1 Gene

Proteomics data for SIKE1 Gene at MOPED

Post-translational modifications for SIKE1 Gene

  • Ubiquitination at Lys 154
  • Modification sites at PhosphoSitePlus

Other Protein References for SIKE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIKE1 Gene

Domains & Families for SIKE1 Gene

Protein Domains for SIKE1 Gene


Suggested Antigen Peptide Sequences for SIKE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIKE family.
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with SIKE1: view

No data available for Gene Families for SIKE1 Gene

Function for SIKE1 Gene

Molecular function for SIKE1 Gene

UniProtKB/Swiss-Prot Function:
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Phenotypes for SIKE1 Gene

GenomeRNAi human phenotypes for SIKE1:
genes like me logo Genes that share phenotypes with SIKE1: view

Animal Model Products

miRNA for SIKE1 Gene

miRTarBase miRNAs that target SIKE1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIKE1 Gene

Localization for SIKE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIKE1 Gene


Subcellular locations from

Jensen Localization Image for SIKE1 Gene COMPARTMENTS Subcellular localization image for SIKE1 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for SIKE1 Gene

Pathways & Interactions for SIKE1 Gene

genes like me logo Genes that share pathways with SIKE1: view

Gene Ontology (GO) - Biological Process for SIKE1 Gene


No data available for SIGNOR curated interactions for SIKE1 Gene

Drugs & Compounds for SIKE1 Gene

No Compound Related Data Available

Transcripts for SIKE1 Gene

Unigene Clusters for SIKE1 Gene

Suppressor of IKBKE 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for SIKE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIKE1 Gene

mRNA expression in normal human tissues for SIKE1 Gene

Protein differential expression in normal tissues from HIPED for SIKE1 Gene

This gene is overexpressed in Plasma (17.0), Peripheral blood mononuclear cells (14.8), Pancreatic juice (10.4), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIKE1 Gene

SOURCE GeneReport for Unigene cluster for SIKE1 Gene Hs.709277

mRNA Expression by UniProt/SwissProt for SIKE1 Gene

Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
genes like me logo Genes that share expression patterns with SIKE1: view

Protein tissue co-expression partners for SIKE1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SIKE1 Gene

Orthologs for SIKE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIKE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIKE1 35
  • 94.36 (n)
  • 95.65 (a)
SIKE1 36
  • 95 (a)
(Canis familiaris)
Mammalia SIKE1 35
  • 94.47 (n)
  • 97.63 (a)
SIKE1 36
  • 98 (a)
(Mus musculus)
Mammalia Sike1 35
  • 86.8 (n)
  • 91.79 (a)
Sike1 16
Sike1 36
  • 91 (a)
(Pan troglodytes)
Mammalia SIKE1 35
  • 99.36 (n)
  • 100 (a)
SIKE1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sike1 35
  • 86.96 (n)
  • 90.82 (a)
(Monodelphis domestica)
Mammalia SIKE1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia SIKE1 36
  • 88 (a)
(Gallus gallus)
Aves SIKE1 35
  • 70.57 (n)
  • 74.63 (a)
SIKE1 36
  • 69 (a)
(Anolis carolinensis)
Reptilia SIKE1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sike1 35
  • 68.01 (n)
  • 69.7 (a)
Str.10737 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12065 35
(Danio rerio)
Actinopterygii LOC568173 35
  • 62.94 (n)
  • 60.19 (a)
SIKE1 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10158 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8091 36
  • 29 (a)
Species with no ortholog for SIKE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIKE1 Gene

Gene Tree for SIKE1 (if available)
Gene Tree for SIKE1 (if available)

Paralogs for SIKE1 Gene

Paralogs for SIKE1 Gene

(1) SIMAP similar genes for SIKE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SIKE1: view

Variants for SIKE1 Gene

Sequence variations from dbSNP and Humsavar for SIKE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3827739 -- 114,773,537(-) ATACT(A/G)AAAGT nc-transcript-variant, utr-variant-3-prime
rs6683934 -- 114,779,000(+) tgcag(C/T)gagcc intron-variant
rs11588393 -- 114,772,908(+) TTTTA(A/G)GACAT nc-transcript-variant, utr-variant-3-prime
rs12143357 -- 114,778,702(+) ACATG(A/T)AAGGA intron-variant
rs12724003 -- 114,781,206(+) agtga(A/T)ccgcc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIKE1 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv824265 CNV Gain 20364138
esv2716496 CNV Deletion 23290073
esv2716507 CNV Deletion 23290073
esv2716518 CNV Deletion 23290073

Variation tolerance for SIKE1 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIKE1 Gene

Disorders for SIKE1 Gene

Relevant External Links for SIKE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIKE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIKE1 Gene

Publications for SIKE1 Gene

  1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PMID: 16281057) Huang J. … Shu H.-B. (EMBO J. 2005) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3

Products for SIKE1 Gene

Sources for SIKE1 Gene