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SIK3 Gene

protein-coding   GIFtS: 57
GCID: GC11M116714

SIK Family Kinase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SIK Family Kinase 31 2     EC 2.7.11.13 8
Salt-Inducible Kinase 32 3     KIAA09993 5
Serine/Threonine-Protein Kinase QSK2 3     Serine/Threonine-Protein Kinase SIK32
QSK2 3     EC 2.7.118
SIK-32 3     

External Ids:    HGNC: 291651   Entrez Gene: 233872   Ensembl: ENSG000001605847   OMIM: 6147765   UniProtKB: Q9Y2K23   

Export aliases for SIK3 gene to outside databases

Previous GC identifers: GC11M116222 GC11M112646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIK3 Gene:
SIK3 (SIK family kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is BRSK1.

Gene Wiki entry for SIK3 (KIAA0999) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SIK3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIK3 promoter sequence
   Search Chromatin IP Primers for SIK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

SIK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M116714:  view genomic region     (about GC identifiers)

Start:
116,714,118 bp from pter      End:
116,969,153 bp from pter
Size:
255,036 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIK3_HUMAN, Q9Y2K2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK3  
Size: 1263 amino acids; 139980 Da
Cofactor: Magnesium
Subunit: Binds to and is activated by YWHAZ when phosphorylated on Thr-163
Sequence caution: Sequence=AAT06749.1; Type=Erroneous initiation; Sequence=BAA76843.2; Type=Erroneous initiation;
Sequence=BAB14006.1; Type=Erroneous initiation;
Secondary accessions: Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50
Alternative splicing: 3 isoforms:  Q9Y2K2-1   Q9Y2K2-2   Q9Y2K2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIK3: NX_Q9Y2K2

Explore proteomics data for SIK3 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB391
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SIK3 (Q9Y2K2) (see all 11)
     EYASGGE  GNFAVVK  LVAHGRM  LYQVMET 


    See SIK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001268677.1  NP_001268678.1  NP_079440.3  

    ENSEMBL proteins: 
     ENSP00000391295   ENSP00000364449   ENSP00000392849   ENSP00000392761   ENSP00000390442  
     ENSP00000414347   ENSP00000292055   ENSP00000438108   ENSP00000415873   ENSP00000364437  

    SIK3 Human Recombinant Protein Products:

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    Novus Biologicals SIK3 Protein
    Novus Biologicals SIK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIK3

     
    Search eBioscience for Proteins for SIK3 

     
    antibodies-online proteins for SIK3 (2 products) 

     
    antibodies-online peptides for SIK3

    SIK3 Antibody Products:

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    antibodies-online antibodies for SIK3 (23 products) 

    SIK3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SIK3
    Cloud-Clone Corp. CLIAs for SIK3
    Search eBioscience for ELISAs for SIK3 
    antibodies-online kits for SIK3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: SIK family kinase 3
    QIK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2K2

    ProtoNet protein and cluster: Q9Y2K2

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK3_HUMAN, Q9Y2K2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with SIK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK3_HUMAN, Q9Y2K2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-163 (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16306228
         
    Find genes that share ontologies with SIK3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIK3:
     Decreased substrate adherent c 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sik3):
     adipose tissue  behavior/neurological  cellular  craniofacial  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging  renal/urinary system  skeleton 

    Find genes that share phenotypes with SIK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sik3tm1Htake for SIK3

       genOway: Develop your customized and physiologically relevant rodent model for SIK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SIK3:
    hsa-mir-454-3p (MIRT039234)

    Block miRNA regulation of human, mouse, rat SIK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK3 (see all 52):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-30d hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSIK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIK3
    Predesigned siRNA for gene silencing in human, mouse, rat SIK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SIK3

    Clone
    Products:
         
    OriGene clones in human, mouse for SIK3 (see all 7)
    OriGene ORF clones in mouse, rat for SIK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIK3 (NM_025164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK3
    Addgene plasmids for SIK3 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIK3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIK3_HUMAN, Q9Y2K2: Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SIK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIK3 About    
    See pathways by source

    SuperPathContained pathways About
    1LKB1 signaling events
    LKB1 signaling events


    1 BioSystems Pathway for SIK3
        LKB1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIK3
    Interactions:

        Search GeneGlobe Interaction Network for SIK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIK3 (Q9Y2K21, 3 ENSP000002920554) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 3, ENSP000003095034EBI-1181460,EBI-347088 I2D: score=4 STRING: ENSP00000309503
    PRKACAP176123, ENSP000003095914I2D: score=3 STRING: ENSP00000309591
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001958endochondral ossification IEA--
    GO:0006468protein phosphorylation IDA14976552
    GO:0032880regulation of protein localization IEA--
    GO:0035108limb morphogenesis IEA--
    GO:0035264multicellular organism growth IEA--

    Find genes that share ontologies with SIK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIK3

    1 HMDB Compound for SIK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIK3 gene (3 alternative transcripts): 
    NM_001281748.1  NM_001281749.1  NM_025164.4  

    Unigene Cluster for SIK3:

    SIK family kinase 3
    Hs.167451  [show with all ESTs]
    Unigene Representative Sequence: AL832068
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488337(uc001ppx.3) ENST00000445177(uc001pqa.3) ENST00000375300(uc001ppw.3 uc001ppy.3 uc001ppz.3)
    ENST00000454905 ENST00000465421 ENST00000415541 ENST00000446921 ENST00000480468(uc001pqb.3)
    ENST00000480222 ENST00000413553 ENST00000472648 ENST00000497049 ENST00000485363
    ENST00000292055 ENST00000542607 ENST00000434315 ENST00000375288
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK3 (see all 52):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-30d hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSIK3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat SIK3
    Clone
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    OriGene ORF clones in mouse, rat for SIK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIK3 (NM_025164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK3
    Addgene plasmids for SIK3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SIK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIK3
      QuantiTect SYBR Green Assays in human, mouse, rat SIK3
      QuantiFast Probe-based Assays in human, mouse, rat SIK3

    Additional mRNA sequence: 

    AB209327.1 AK022302.1 AL832068.1 AY598338.1 BC035583.2 BC063887.1 BC086858.1 BC121188.1 
    BC128510.1 BC128511.1 

    17 DOTS entries:

    DT.95271797  DT.100688539  DT.113790  DT.97861788  DT.97806809  DT.100752439  DT.120733220  DT.432286 
    DT.95139602  DT.86855995  DT.92017155  DT.95271799  DT.120733200  DT.120733214  DT.100873046  DT.95143211 
    DT.97794558 

    Selected AceView cDNA sequences (see all 245):

    AW131264 BI962579 AI248595 BM682365 CD724130 AA418213 CD365476 AY598338 
    AW612324 AU121916 BX104866 BC035583 AI891033 BM717834 AW134872 AI631853 
    AA420986 CD370418 AL539710 AI613081 BF448128 AI493355 BM457273 CD369218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGTATG
    SIK3 Expression
    About this image


    SIK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SIK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167451
        Custom PCR Arrays for SIK3
    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat SIK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SIK3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sik31 , 5 SIK family kinase 31, 5 88.25(n)1
    91.49(a)1
      9 (25.36 cM)5
    706611  NM_027498.31  NP_081774.31 
     460128205 
    chicken
    (Gallus gallus)
    Aves LOC7773171 serine/threonine-protein kinase SIK3-like 78.73(n)
    84.59(a)
      777317  XM_003642604.2  XP_003642652.2 
    lizard
    (Anolis carolinensis)
    Reptilia SIK36
    SIK family kinase 3
    71(a)
    1 ↔ 1
    GL343949.1(24401-45944)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX850188.12   -- 79.15(n)    BX850188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661012 hypothetical protein MGC66101 73.36(n)   393513  BC056316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sik26
    Salt-inducible kinase 2
    29(a)
    1 ↔ 1
    X(1949343-1955948)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-296
    Protein KIN-29 (kin-29) mRNA, complete cds
    27(a)
    1 → many
    X(2844004-2852479) WBGene00002210


    ENSEMBL Gene Tree for SIK3 (if available)
    TreeFam Gene Tree for SIK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIK3 gene
    BRSK12  MARK12  BRSK22  SNRK2  SIK22  MARK22  NIM1K2  SIK12  
    MARK42  MARK32  
    Selected SIMAP similar genes for SIK3 using alignment to 8 protein entries:     SIK3_HUMAN (see all proteins) (see all similar genes):
    KIAA0999    MARK4    MARK1    MARK3    PRKAA1    BRSK2
    HUNK    MAPK3    NIM1K    TSSK3    NUAK1    BRAF
    CAMK2A    MARK2    PRKD3    PRKCB    CAMK2B    TSSK1

    Find genes that share paralogs with SIK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIK3 (see all 5326)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356354
    A breast cancer sample4--see VAR_0356352 A V mis40--------
    VAR_0356344
    A breast cancer sample4--see VAR_0356342 H L mis40--------
    rs557085021,2
    Cuntested1116738795(+) CCTATA/G/TTGCCA 1 -- int10--------
    rs577169311,2
    C--112690246(+) AAAAA-/A/AA  
            
    GTATA
    1 -- int11NA 2
    rs601029231,2
    C--112772096(+) AAAAA-/A/AAA 
            
    GACAT
    1 -- int11NA 2
    rs57950561,2
    C--116621748(+) acact-/Aaaaaa 1 -- int1 trp30--------
    rs5791631,2
    C,A--116713630(+) CCAGGG/CCCCTC 1 -- ds50015Minor allele frequency- C:0.36NA 128
    rs1455174011,2
    --116713635(+) CCCCTC/TCCTTT 1 -- ds50010--------
    rs1488413091,2
    C--116713690(+) GGTCAC/TGTCAT 1 -- ds50010--------
    rs1887735101,2
    --116713774(+) GTTTTC/GCACCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIK3 (116714118 - 116964118 bp, first 250kb of SIK3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIK3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678480CNV Deletion23128226
    dgv245e199CNV Deletion23128226
    nsv507620CNV Insertion20534489
    esv267714CNV Insertion20981092
    esv1183056CNV Insertion17803354
    esv24446CNV Loss19812545
    dgv245n67CNV Loss20364138
    nsv898403CNV Gain21882294
    nsv898402CNV Gain21882294
    nsv832280CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614776    OMIM disorders: --


    Find genes that share disorders with SIK3           About GenesLikeMe

    Genetic Association Database (GAD): SIK3
    Human Genome Epidemiology (HuGE) Navigator: SIK3 (2 documents)

    Export disorders for SIK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIK3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SIK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. (PubMed id 22306654)1, 4 Feenstra B....Melbye M. (Nat. Genet. 2012)
    3. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. (PubMed id 21149283)1, 4 Oexle K....Meitinger T. (Hum. Mol. Genet. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. (PubMed id 18193046)1, 4 Kooner J.S....Thompson J.F. (Nat. Genet. 2008)
    6. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PubMed id 16306228)1, 2 Al-Hakim A.K.... Alessi D.R. (J. Cell Sci. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    9. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23387 HGNC: 29165 AceView: KIAA0999 Ensembl:ENSG00000160584 euGenes: HUgn23387
    ECgene: SIK3 H-InvDB: SIK3

    (According to HUGE)
    About This Section

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    HUGE: KIAA0999

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SIK3 gene:
    Search GeneIP for patents involving SIK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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