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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIK3 Gene

protein-coding   GIFtS: 56
GCID: GC11M116714

SIK Family Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SIK Family Kinase 31 2     EC 2.7.11.13 8
Salt-Inducible Kinase 32 3     Serine/Threonine-Protein Kinase SIK32
Serine/Threonine-Protein Kinase QSK2 3     KIAA09993
QSK2 3     EC 2.7.118
SIK-32 3     

External Ids:    HGNC: 291651   Entrez Gene: 233872   Ensembl: ENSG000001605847   OMIM: 6147765   UniProtKB: Q9Y2K23   

Export aliases for SIK3 gene to outside databases

Previous GC identifers: GC11M116222 GC11M112646


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIK3 Gene: 
SIK3 (SIK family kinase 3) is a protein-coding gene. Diseases associated with SIK3 include hypertrophic pyloric stenosis, and pyloric stenosis. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is NUAK1.

Gene Wiki entry for SIK3 (KIAA0999) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SIK3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

SIK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M116714:  view genomic region     (about GC identifiers)

Start:
116,714,118 bp from pter      End:
116,969,153 bp from pter
Size:
255,036 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIK3_HUMAN, Q9Y2K2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK3  
Size: 1263 amino acids; 139980 Da
Cofactor: Magnesium
Subunit: Binds to and is activated by YWHAZ when phosphorylated on Thr-163
Subcellular location: Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ
Sequence caution: Sequence=AAT06749.1; Type=Erroneous initiation; Sequence=BAA76843.2; Type=Erroneous initiation;
Sequence=BAB14006.1; Type=Erroneous initiation;
Secondary accessions: Q59FY2 Q5M9N1 Q6P3R6 Q8IYM8 Q9HA50
Alternative splicing: 3 isoforms:  Q9Y2K2-1   Q9Y2K2-2   Q9Y2K2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIK3: NX_Q9Y2K2

Explore proteomics data for SIK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2K2

  • 4/11 DME Specific Peptides for SIK3 (Q9Y2K2) (see all 11)
     EYASGGE  GNFAVVK  LVAHGRM  LYQVMET 

    SIK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIK3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001268677.1  NP_001268678.1  NP_079440.3  

    ENSEMBL proteins: 
     ENSP00000391295   ENSP00000364449   ENSP00000392849   ENSP00000392761   ENSP00000390442  
     ENSP00000414347   ENSP00000292055   ENSP00000438108   ENSP00000415873   ENSP00000364437  

    Human Recombinant Protein Products for SIK3: 
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    Novus Biologicals SIK3 Protein
    Novus Biologicals SIK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIK3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SIK3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: SIK family kinase 3 
    QIK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y2K2

    ProtoNet protein and cluster: Q9Y2K2

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK3_HUMAN, Q9Y2K2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    SIK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK3_HUMAN, Q9Y2K2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-163 (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16306228
         
    SIK3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIK3:
     Decreased substrate adherent c 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sik3):
     adipose tissue  behavior/neurological  cellular  craniofacial  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging  renal/urinary system  skeleton 

    SIK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sik3tm1Htake for SIK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIK3 

    miRNA
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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK3 (see all 52):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-30d hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSIK3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1LKB1 signaling events
    LKB1 signaling events


    1 BioSystems Pathway for SIK3
        LKB1 signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for SIK3 (Q9Y2K21, 3 ENSP000002920554) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 3, ENSP000003095034EBI-1181460,EBI-347088 I2D: score=4 STRING: ENSP00000309503
    PRKACAP176123, ENSP000003095914I2D: score=3 STRING: ENSP00000309591
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14976552

    SIK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIK3

    1 HMDB Compound for SIK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about SIK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIK3 gene (3 alternative transcripts): 
    NM_001281748.1  NM_001281749.1  NM_025164.4  

    Unigene Cluster for SIK3:

    SIK family kinase 3
    Hs.167451  [show with all ESTs]
    Unigene Representative Sequence: AL832068
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488337(uc001ppx.3) ENST00000445177(uc001pqa.3) ENST00000375300(uc001ppw.3 uc001ppy.3 uc001ppz.3)
    ENST00000454905 ENST00000465421 ENST00000415541 ENST00000446921 ENST00000480468(uc001pqb.3)
    ENST00000480222 ENST00000413553 ENST00000472648 ENST00000497049 ENST00000485363
    ENST00000292055 ENST00000542607 ENST00000434315 ENST00000375288
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIK3
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK3 (see all 52):
    hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-485-3p hsa-miR-30d hsa-miR-578 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidSIK3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIK3

    Additional mRNA sequence: 

    AB209327.1 AK022302.1 AL832068.1 AY598338.1 BC035583.2 BC063887.1 BC086858.1 BC121188.1 
    BC128510.1 BC128511.1 

    17 DOTS entries:

    DT.95271797  DT.100688539  DT.113790  DT.97861788  DT.97806809  DT.100752439  DT.120733220  DT.432286 
    DT.95139602  DT.86855995  DT.92017155  DT.95271799  DT.120733200  DT.120733214  DT.100873046  DT.95143211 
    DT.97794558 

    24/245 AceView cDNA sequences (see all 245):

    AW131264 BI962579 AI248595 BM682365 CD724130 AA418213 CD365476 AY598338 
    AW612324 AU121916 BX104866 BC035583 AI891033 BM717834 AW134872 AI631853 
    AA420986 CD370418 AL539710 AI613081 BF448128 AI493355 BM457273 CD369218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGTATG
    SIK3 Expression
    About this image


    See SIK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIK3

    SOURCE GeneReport for Unigene cluster: Hs.167451
        SABiosciences Custom PCR Arrays for SIK3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SIK3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sik31 , 5 SIK family kinase 31, 5 88.82(n)1
    91.91(a)1
      9 (25.36 cM)5
    706611  NM_027498.31  NP_081774.31 
     460128205 
    chicken
    (Gallus gallus)
    Aves LOC7773171 serine/threonine-protein kinase SIK3-like 78.38(n)
    83.76(a)
      777317  XM_003642604.1  XP_003642652.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIK36
    SIK family kinase 3
    71(a)
    1 ↔ 1
    GL343949.1(24401-45944)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX850188.12   -- 79.15(n)    BX850188.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661012 hypothetical protein MGC66101 73.36(n)   393513  BC056316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sik26
    Salt-inducible kinase 2
    18(a)
    1 → many
    X(1949343-1955948)


    ENSEMBL Gene Tree for SIK3 (if available)
    TreeFam Gene Tree for SIK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIK3 gene
    NUAK12  MARK12  PRKAA22  SNRK2  SIK22  PRKAA12  NUAK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    18/86 SIMAP similar genes for SIK3 using alignment to 8 protein entries:     SIK3_HUMAN (see all proteins) (see all similar genes):
    KIAA0999    MARK4    MARK1    MARK3    PRKAA1    BRSK2
    HUNK    MAPK3    NUAK1    NIM1    TSSK3    BRAF
    CAMK2A    MARK2    PRKD3    PRKCB    TSSK1    TSSK1B

    SIK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5326 SNPs in SIK3 are shown (see all 5326)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356354
    A breast cancer sample4--see VAR_0356352 A V mis40--------
    VAR_0356344
    A breast cancer sample4--see VAR_0356342 H L mis40--------
    rs557085021,2
    Cuntested1116738795(+) CCTATA/G/TTGCCA 1 -- int10--------
    rs577169311,2
    C--112690246(+) AAAAA-/A/AA  
            
    GTATA
    1 -- int11NA 2
    rs601029231,2
    C--112772096(+) AAAAA-/A/AAA 
            
    GACAT
    1 -- int11NA 2
    rs57950561,2
    C--116621748(+) acact-/Aaaaaa 1 -- int1 trp30--------
    rs5791631,2
    C,A--116713630(+) CCAGGG/CCCCTC 1 -- ds50015Minor allele frequency- C:0.36NA 128
    rs1455174011,2
    --116713635(+) CCCCTC/TCCTTT 1 -- ds50010--------
    rs1488413091,2
    C--116713690(+) GGTCAC/TGTCAT 1 -- ds50010--------
    rs1887735101,2
    --116713774(+) GTTTTC/GCACCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIK3 (116714118 - 116964118 bp, first 250kb of SIK3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for SIK3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678480CNV Deletion23128226
    dgv245e199CNV Deletion23128226
    nsv507620CNV Insertion20534489
    esv267714CNV Insertion20981092
    esv1183056CNV Insertion17803354
    esv24446CNV Loss19812545
    dgv245n67CNV Loss20364138
    nsv898403CNV Gain21882294
    nsv898402CNV Gain21882294
    nsv832280CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614776    OMIM disorders: --

    7 diseases for SIK3:    About MalaCards
    hypertrophic pyloric stenosis    pyloric stenosis    pancreatic cancer    ovarian cancer
    colorectal cancer    pancreatitis    lung cancer


    SIK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIK3
    Human Genome Epidemiology (HuGE) Navigator: SIK3 (2 documents)

    Export disorders for SIK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIK3 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SIK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Common variants near MBNL1 and NKX2-5 are associated w ith infantile hypertrophic pyloric stenosis. (PubMed id 22306654)1, 4 Feenstra B....Melbye M. (2012)
    3. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. (PubMed id 21149283)1, 4 Oexle K....Meitinger T. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. (PubMed id 18193046)1, 4 Kooner J.S....Thompson J.F. (2008)
    6. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PubMed id 16306228)1, 2 Al-Hakim A.K.... Alessi D.R. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
    9. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23387 HGNC: 29165 AceView: KIAA0999 Ensembl:ENSG00000160584 euGenes: HUgn23387
    ECgene: SIK3 H-InvDB: SIK3

    (According to HUGE)
    About This Section
    HUGE: KIAA0999

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIK3 gene:
    Search GeneIP for patents involving SIK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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