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Aliases for SIK3 Gene

Aliases for SIK3 Gene

  • SIK Family Kinase 3 2 3
  • Serine/Threonine-Protein Kinase QSK 3 4
  • Salt-Inducible Kinase 3 3 4
  • EC 4 63
  • KIAA0999 4 6
  • SIK-3 3 4
  • QSK 3 4
  • Serine/Threonine-Protein Kinase SIK3 3
  • EC 2.7.11 63
  • L19 3

External Ids for SIK3 Gene

Previous GeneCards Identifiers for SIK3 Gene

  • GC11M116222
  • GC11M116714
  • GC11M112646

Summaries for SIK3 Gene

GeneCards Summary for SIK3 Gene

SIK3 (SIK Family Kinase 3) is a Protein Coding gene. Among its related pathways are LKB1 signaling events. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MARK4.

Gene Wiki entry for SIK3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK3 Gene

Genomics for SIK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIK3 Gene

116,843,402 bp from pter
117,098,437 bp from pter
255,036 bases
Minus strand

Genomic View for SIK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK3 Gene

No data available for Regulatory Elements for SIK3 Gene

Proteins for SIK3 Gene

  • Protein details for SIK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase SIK3
    Protein Accession:
    Secondary Accessions:
    • A1A5A8
    • Q59FY2
    • Q5M9N1
    • Q6P3R6
    • Q8IYM8
    • Q9HA50

    Protein attributes for SIK3 Gene

    1263 amino acids
    Molecular mass:
    139980 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to and is activated by YWHAZ when phosphorylated on Thr-163
    • Sequence=AAT06749.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76843.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14006.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIK3 Gene


neXtProt entry for SIK3 Gene

Proteomics data for SIK3 Gene at MOPED

Selected DME Specific Peptides for SIK3 Gene

Post-translational modifications for SIK3 Gene

  • Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for SIK3 Gene

Gene Families for SIK3 Gene

Suggested Antigen Peptide Sequences for SIK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2K2
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK3: view

Function for SIK3 Gene

Molecular function for SIK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-163.

Enzyme Numbers (IUBMB) for SIK3 Gene

Gene Ontology (GO) - Molecular Function for SIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16306228
genes like me logo Genes that share ontologies with SIK3: view
genes like me logo Genes that share phenotypes with SIK3: view

Animal Models for SIK3 Gene

MGI Knock Outs for SIK3:

miRNA for SIK3 Gene

miRTarBase miRNAs that target SIK3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIK3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for SIK3 Gene

Localization for SIK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK3 Gene

Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.

Subcellular locations from

Jensen Localization Image for SIK3 Gene COMPARTMENTS Subcellular localization image for SIK3 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIK3: view

Pathways for SIK3 Gene

SuperPathways for SIK3 Gene

Superpath Contained pathways
1 LKB1 signaling events
genes like me logo Genes that share pathways with SIK3: view

Pathways by source for SIK3 Gene

1 BioSystems pathway for SIK3 Gene

Interacting Proteins for SIK3 Gene

Gene Ontology (GO) - Biological Process for SIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification --
GO:0006468 protein phosphorylation IDA 14976552
GO:0032880 regulation of protein localization --
GO:0035108 limb morphogenesis --
GO:0035264 multicellular organism growth --
genes like me logo Genes that share ontologies with SIK3: view

Compounds for SIK3 Gene

(1) HMDB Compounds for SIK3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium
genes like me logo Genes that share compounds with SIK3: view

Transcripts for SIK3 Gene

Unigene Clusters for SIK3 Gene

SIK family kinase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIK3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIK3 Gene

No ASD Table

Relevant External Links for SIK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIK3 Gene

mRNA expression in normal human tissues for SIK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SIK3 Gene

This gene is overexpressed in Lung (13.4), Peripheral blood mononuclear cells (9.0), Frontal cortex (7.1), and Testis (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SIK3 Gene

SOURCE GeneReport for Unigene cluster for SIK3 Gene Hs.167451

genes like me logo Genes that share expressions with SIK3: view

Expression partners for SIK3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIK3 Gene

Orthologs for SIK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIK3 35
  • 89.82 (n)
  • 93.99 (a)
SIK3 36
  • 88 (a)
(Canis familiaris)
Mammalia SIK3 35
  • 90.32 (n)
  • 92.89 (a)
SIK3 36
  • 90 (a)
(Mus musculus)
Mammalia Sik3 35
  • 88.25 (n)
  • 91.49 (a)
Sik3 16
Sik3 36
  • 85 (a)
(Pan troglodytes)
Mammalia SIK3 35
  • 99.68 (n)
  • 99.81 (a)
SIK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sik3 35
  • 88.11 (n)
  • 91.17 (a)
(Monodelphis domestica)
Mammalia SIK3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SIK3 36
  • 78 (a)
(Gallus gallus)
Aves LOC777317 35
  • 78.73 (n)
  • 84.59 (a)
-- 36
  • 79 (a)
-- 36
  • 78 (a)
-- 36
  • 76 (a)
-- 36
  • 76 (a)
-- 36
  • 76 (a)
-- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia SIK3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sik3 35
  • 71.49 (n)
  • 75.9 (a)
(Danio rerio)
Actinopterygii zgc66101 35
zgc:66101 35
  • 65.45 (n)
  • 67.82 (a)
SIK3 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sik2 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea kin-29 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for SIK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK3 Gene

Gene Tree for SIK3 (if available)
Gene Tree for SIK3 (if available)

Paralogs for SIK3 Gene

Paralogs for SIK3 Gene

genes like me logo Genes that share paralogs with SIK3: view

Variants for SIK3 Gene

Sequence variations from dbSNP and Humsavar for SIK3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3181 -- 117,036,327(+) CTAAT(A/G)GGCTC intron-variant
rs472111 -- 116,846,153(+) TAACC(A/C/G)AACCA intron-variant
rs473172 -- 116,937,254(-) ATATA(C/T)GCATA intron-variant
rs473188 -- 116,941,313(+) AAATA(C/G)CTTTT intron-variant
rs474223 -- 116,941,456(+) TTCAA(A/C)CAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIK3 Gene

Variant ID Type Subtype PubMed ID
nsv898402 CNV Gain 21882294
dgv245e199 CNV Deletion 23128226
esv24446 CNV Loss 19812545
nsv832280 CNV Gain+Loss 17160897
nsv898403 CNV Gain 21882294
esv1183056 CNV Insertion 17803354
nsv507620 CNV Insertion 20534489
esv267714 CNV Insertion 20981092
dgv245n67 CNV Loss 20364138
esv2678480 CNV Deletion 23128226
nsv7223 OTHER Inversion 18451855

Relevant External Links for SIK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK3 Gene

Disorders for SIK3 Gene

Relevant External Links for SIK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SIK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SIK3 Gene

Publications for SIK3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SIK3 Gene

Sources for SIK3 Gene

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