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Aliases for SIK3 Gene

Aliases for SIK3 Gene

  • SIK Family Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase QSK 3 4
  • Salt-Inducible Kinase 3 3 4
  • EC 4 63
  • SIK-3 3 4
  • QSK 3 4
  • EC 2.7.11 63
  • KIAA0999 4
  • L19 3

External Ids for SIK3 Gene

Previous GeneCards Identifiers for SIK3 Gene

  • GC11M116222
  • GC11M116714
  • GC11M112646

Summaries for SIK3 Gene

GeneCards Summary for SIK3 Gene

SIK3 (SIK Family Kinase 3) is a Protein Coding gene. Among its related pathways are LKB1 signaling events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LOC102724428.

Gene Wiki entry for SIK3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK3 Gene

Genomics for SIK3 Gene

Regulatory Elements for SIK3 Gene

Enhancers for SIK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIK3 on UCSC Golden Path with GeneCards custom track

Promoters for SIK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIK3 Gene

116,843,402 bp from pter
117,098,453 bp from pter
255,052 bases
Minus strand

Genomic View for SIK3 Gene

Genes around SIK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK3 Gene

Proteins for SIK3 Gene

  • Protein details for SIK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase SIK3
    Protein Accession:
    Secondary Accessions:
    • A1A5A8
    • Q59FY2
    • Q5M9N1
    • Q6P3R6
    • Q8IYM8
    • Q9HA50

    Protein attributes for SIK3 Gene

    1263 amino acids
    Molecular mass:
    139980 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to and is activated by YWHAZ when phosphorylated on Thr-163.
    • Sequence=AAT06749.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA76843.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14006.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIK3 Gene


neXtProt entry for SIK3 Gene

Proteomics data for SIK3 Gene at MOPED

Selected DME Specific Peptides for SIK3 Gene

Post-translational modifications for SIK3 Gene

  • Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for SIK3 Gene

Gene Families for SIK3 Gene

Suggested Antigen Peptide Sequences for SIK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK3: view

Function for SIK3 Gene

Molecular function for SIK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-163.

Enzyme Numbers (IUBMB) for SIK3 Gene

Gene Ontology (GO) - Molecular Function for SIK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0005524 ATP binding IEA,IDA 14976552
genes like me logo Genes that share ontologies with SIK3: view
genes like me logo Genes that share phenotypes with SIK3: view

Animal Models for SIK3 Gene

MGI Knock Outs for SIK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK3 Gene

Localization for SIK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK3 Gene

Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.

Subcellular locations from

Jensen Localization Image for SIK3 Gene COMPARTMENTS Subcellular localization image for SIK3 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SIK3 Gene

Pathways & Interactions for SIK3 Gene

SuperPathways for SIK3 Gene

Superpath Contained pathways
1 LKB1 signaling events
genes like me logo Genes that share pathways with SIK3: view

Pathways by source for SIK3 Gene

1 BioSystems pathway for SIK3 Gene

Interacting Proteins for SIK3 Gene

SIGNOR curated interactions for SIK3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SIK3 Gene


Drugs & Compounds for SIK3 Gene

(1) Drugs for SIK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with SIK3: view

Transcripts for SIK3 Gene

Unigene Clusters for SIK3 Gene

SIK family kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIK3 Gene

No ASD Table

Relevant External Links for SIK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIK3 Gene

mRNA expression in normal human tissues for SIK3 Gene

Protein differential expression in normal tissues from HIPED for SIK3 Gene

This gene is overexpressed in Lung (13.4), Peripheral blood mononuclear cells (9.0), Frontal cortex (7.1), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SIK3 Gene

SOURCE GeneReport for Unigene cluster for SIK3 Gene Hs.167451

genes like me logo Genes that share expression patterns with SIK3: view

Protein tissue co-expression partners for SIK3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIK3 Gene

Orthologs for SIK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIK3 35
  • 89.82 (n)
  • 93.99 (a)
SIK3 36
  • 88 (a)
(Canis familiaris)
Mammalia SIK3 35
  • 90.32 (n)
  • 92.89 (a)
SIK3 36
  • 90 (a)
(Mus musculus)
Mammalia Sik3 35
  • 88.25 (n)
  • 91.49 (a)
Sik3 16
Sik3 36
  • 85 (a)
(Pan troglodytes)
Mammalia SIK3 35
  • 99.68 (n)
  • 99.81 (a)
SIK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sik3 35
  • 88.11 (n)
  • 91.17 (a)
(Monodelphis domestica)
Mammalia SIK3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SIK3 36
  • 78 (a)
(Gallus gallus)
Aves LOC777317 35
  • 78.73 (n)
  • 84.59 (a)
-- 36
  • 79 (a)
-- 36
  • 78 (a)
-- 36
  • 76 (a)
-- 36
  • 76 (a)
-- 36
  • 76 (a)
-- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia SIK3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sik3 35
  • 71.49 (n)
  • 75.9 (a)
(Danio rerio)
Actinopterygii zgc66101 35
zgc:66101 35
  • 65.45 (n)
  • 67.82 (a)
SIK3 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sik2 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea kin-29 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for SIK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK3 Gene

Gene Tree for SIK3 (if available)
Gene Tree for SIK3 (if available)

Paralogs for SIK3 Gene

genes like me logo Genes that share paralogs with SIK3: view

Variants for SIK3 Gene

Sequence variations from dbSNP and Humsavar for SIK3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035634 A breast cancer sample
VAR_035635 A breast cancer sample
rs11216163 - 116,858,027(+) GAGCA(A/C/G)TCCTC reference, missense
rs12225230 - 116,857,914(+) ATTCA(C/G/T)GGTCC reference, missense
rs519794 -- 116,988,737(+) ttcag(C/G/T)gagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIK3 Gene

Variant ID Type Subtype PubMed ID
nsv898402 CNV Gain 21882294
dgv245e199 CNV Deletion 23128226
esv24446 CNV Loss 19812545
nsv832280 CNV Gain+Loss 17160897
nsv898403 CNV Gain 21882294
esv1183056 CNV Insertion 17803354
nsv507620 CNV Insertion 20534489
esv267714 CNV Insertion 20981092
dgv245n67 CNV Loss 20364138
esv2678480 CNV Deletion 23128226
nsv7223 OTHER Inversion 18451855

Variation tolerance for SIK3 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIK3 Gene

Disorders for SIK3 Gene

Relevant External Links for SIK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIK3 Gene

Publications for SIK3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. (PMID: 24743732) Chen H. … Poon R.Y. (Cell Death Dis 2014) 3
  5. Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. (PMID: 24886709) Ko A. … Pajukanta P. (Nat Commun 2014) 3

Products for SIK3 Gene

Sources for SIK3 Gene