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Aliases for SIK2 Gene

Aliases for SIK2 Gene

  • Salt Inducible Kinase 2 2 3 5
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 2 3 4
  • Salt-Inducible Kinase 2 3 4
  • SNF1-Like Kinase 2 2 3
  • Qin-Induced Kinase 3 4
  • EC 2.7.11.1 4 63
  • SNF1LK2 3 4
  • SIK-2 3 4
  • QIK 3 4
  • Salt-Inducible Serine/Threonine Kinase 2 3
  • Salt-Inducible Protein Kinase 2 3
  • LOH11CR1I 3
  • EC 2.7.11 63
  • KIAA0781 4

External Ids for SIK2 Gene

Previous HGNC Symbols for SIK2 Gene

  • SNF1LK2

Previous GeneCards Identifiers for SIK2 Gene

  • GC11U900483
  • GC11P111011
  • GC11P110978
  • GC11P111473
  • GC11P107397

Summaries for SIK2 Gene

GeneCards Summary for SIK2 Gene

SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Among its related pathways are Glucagon signaling pathway and LKB1 signaling events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LOC102724428.

UniProtKB/Swiss-Prot for SIK2 Gene

  • Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Wiki entry for SIK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK2 Gene

Genomics for SIK2 Gene

Regulatory Elements for SIK2 Gene

Promoters for SIK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIK2 Gene

Chromosome:
11
Start:
111,602,391 bp from pter
End:
111,732,388 bp from pter
Size:
129,998 bases
Orientation:
Plus strand

Genomic View for SIK2 Gene

Genes around SIK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK2 Gene

Proteins for SIK2 Gene

  • Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0K1-SIK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SIK2
    Protein Accession:
    Q9H0K1
    Secondary Accessions:
    • A8K5B8
    • B0YJ94
    • O94878
    • Q17RV0
    • Q6AZE2
    • Q76N03
    • Q8NCV7
    • Q96CZ8

    Protein attributes for SIK2 Gene

    Size:
    926 amino acids
    Molecular mass:
    103915 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and phosphorylates TORC2/CRTC2.
    SequenceCaution:
    • Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SIK2 Gene

Proteomics data for SIK2 Gene at MOPED

Post-translational modifications for SIK2 Gene

  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Ubiquitination at Lys 692
  • Modification sites at PhosphoSitePlus

Other Protein References for SIK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIK2 (QIK)

Domains & Families for SIK2 Gene

Gene Families for SIK2 Gene

Suggested Antigen Peptide Sequences for SIK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0K1

UniProtKB/Swiss-Prot:

SIK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK2: view

Function for SIK2 Gene

Molecular function for SIK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-175.
UniProtKB/Swiss-Prot Function:
Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Enzyme Numbers (IUBMB) for SIK2 Gene

Gene Ontology (GO) - Molecular Function for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity IEA --
GO:0005524 ATP binding IEA,IDA 14976552
genes like me logo Genes that share ontologies with SIK2: view
genes like me logo Genes that share phenotypes with SIK2: view

Animal Models for SIK2 Gene

MGI Knock Outs for SIK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK2 Gene

Localization for SIK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIK2 Gene COMPARTMENTS Subcellular localization image for SIK2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SIK2 Gene

Pathways & Interactions for SIK2 Gene

genes like me logo Genes that share pathways with SIK2: view

Pathways by source for SIK2 Gene

1 BioSystems pathway for SIK2 Gene
1 KEGG pathway for SIK2 Gene

SIGNOR curated interactions for SIK2 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 14976552
GO:0046777 protein autophosphorylation IDA 18348280
genes like me logo Genes that share ontologies with SIK2: view

Drugs & Compounds for SIK2 Gene

(15) Drugs for SIK2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(9) Additional Compounds for SIK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIK2: view

Transcripts for SIK2 Gene

mRNA/cDNA for SIK2 Gene

Unigene Clusters for SIK2 Gene

Salt-inducible kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIK2 Gene

No ASD Table

Relevant External Links for SIK2 Gene

GeneLoc Exon Structure for
SIK2
ECgene alternative splicing isoforms for
SIK2

Expression for SIK2 Gene

mRNA expression in normal human tissues for SIK2 Gene

mRNA differential expression in normal tissues according to GTEx for SIK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for SIK2 Gene

This gene is overexpressed in Lung (51.5) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIK2 Gene



SOURCE GeneReport for Unigene cluster for SIK2 Gene Hs.269128

genes like me logo Genes that share expression patterns with SIK2: view

Protein tissue co-expression partners for SIK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SIK2 Gene

Orthologs for SIK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIK2 35
  • 88.57 (n)
  • 89.6 (a)
SIK2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIK2 35
  • 89.18 (n)
  • 90.82 (a)
SIK2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sik2 35
  • 88.7 (n)
  • 90.9 (a)
Sik2 16
Sik2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIK2 35
  • 99.89 (n)
  • 99.77 (a)
SIK2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIK2 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIK2 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIK2 35
  • 74.31 (n)
  • 77.87 (a)
SIK2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIK2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sik2 35
  • 70.52 (n)
  • 74.49 (a)
zebrafish
(Danio rerio)
Actinopterygii sik2b 35
  • 65.15 (n)
  • 69.17 (a)
sik2b 36
  • 67 (a)
OneToMany
sik2a 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sik3 36
  • 20 (a)
ManyToMany
KP78b 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea kin-29 36
  • 28 (a)
OneToMany
Species with no ortholog for SIK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK2 Gene

ENSEMBL:
Gene Tree for SIK2 (if available)
TreeFam:
Gene Tree for SIK2 (if available)

Paralogs for SIK2 Gene

(11) SIMAP similar genes for SIK2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIK2 Gene

genes like me logo Genes that share paralogs with SIK2: view

Variants for SIK2 Gene

Sequence variations from dbSNP and Humsavar for SIK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_041093 -
VAR_041094 -
VAR_041095 -
VAR_051667 -
VAR_051668 -

Structural Variations from Database of Genomic Variants (DGV) for SIK2 Gene

Variant ID Type Subtype PubMed ID
nsv510273 CNV Loss 20534489
esv2745076 CNV Deletion 23290073
nsv832269 CNV Loss 17160897

Variation tolerance for SIK2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIK2 Gene

HapMap Linkage Disequilibrium report
SIK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK2 Gene

Disorders for SIK2 Gene

Relevant External Links for SIK2

Genetic Association Database (GAD)
SIK2
Human Genome Epidemiology (HuGE) Navigator
SIK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIK2

No disorders were found for SIK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIK2 Gene

Publications for SIK2 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23 67
  2. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PMID: 20367563) Nagel S. … Macleod R.A. (Leuk. Lymphoma 2010) 3 23
  3. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt- inducible kinase-2. (PMID: 12624099) Horike N. … Okamoto M. (J. Biol. Chem. 2003) 3 23
  4. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. (PMID: 14532992) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 23
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for SIK2 Gene

Sources for SIK2 Gene

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