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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIK2 Gene

protein-coding   GIFtS: 61
GCID: GC11P111473

Salt-Inducible Kinase 2

(Previous name: SNF1-like kinase 2)
(Previous symbol: SNF1LK2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Salt-Inducible Kinase 21 2 3     EC 2.7.11.13 8
SNF1LK21 2 3     KIAA07813 5
SNF1-Like Kinase 21 2     LOH11CR1I2
Qin-Induced Kinase2 3     Salt-Inducible Protein Kinase 22
Serine/Threonine-Protein Kinase SNF1-Like Kinase 22 3     Salt-Inducible Serine/Threonine Kinase 22
QIK2 3     Serine/Threonine-Protein Kinase SIK22
SIK-22 3     EC 2.7.118

External Ids:    HGNC: 216801   Entrez Gene: 232352   Ensembl: ENSG000001701457   OMIM: 6089735   UniProtKB: Q9H0K13   

Export aliases for SIK2 gene to outside databases

Previous GC identifers: GC11U900483 GC11P111011 GC11P110978 GC11P107397


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIK2 Gene: 
SIK2 (salt-inducible kinase 2) is a protein-coding gene. Diseases associated with SIK2 include diffuse large b-cell lymphoma, and behcet's disease. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1
Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency
of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific
coactivators

Gene Wiki entry for SIK2 (SNF1LK2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIK2 gene promoter:
         RFX1   C/EBPbeta   XBP-1   Nkx2-5   CREB   deltaCREB   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

SIK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111473:  view genomic region     (about GC identifiers)

Start:
111,473,115 bp from pter      End:
111,601,577 bp from pter
Size:
128,463 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK2  
Size: 926 amino acids; 103915 Da
Cofactor: Magnesium
Subunit: Interacts with and phosphorylates TORC2/CRTC2
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA34501.3; Type=Erroneous initiation;
Secondary accessions: B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8

Explore the universe of human proteins at neXtProt for SIK2: NX_Q9H0K1

Explore proteomics data for SIK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0K1

  • 4/13 DME Specific Peptides for SIK2 (Q9H0K1) (see all 13)
     IIKLYQV  GNFAVVK  HPHIIKL  LYQVMET 

    SIK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIK2 Protein Expression
    REFSEQ proteins: NP_056006.1  
    ENSEMBL proteins: 
     ENSP00000305976  

    Human Recombinant Protein Products for SIK2: 
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    Novus Biologicals SIK2 Proteins
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    Cloud-Clone Corp. Proteins for SIK2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA--

    SIK2 for ontologies           About GeneDecksing



    SIK2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SIK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: salt-inducible kinase 2 
    QIK subfamily

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR017090 Ser/Thr_kinase_SIK1/2
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9H0K1

    ProtoNet protein and cluster: Q9H0K1

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    SIK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK2_HUMAN, Q9H0K1
    Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency
    of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific
    coactivators
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-175

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    SIK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SIK2:
     Decreased CYP1A1 activity afte  Increased cell death in DLD-1   Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIK2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIK2
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK2 (see all 74):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3916 hsa-miR-3162-5p hsa-miR-637 hsa-miR-200b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSIK2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for SIK2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1LKB1 signaling events
    LKB1 signaling events
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SIK2
        Glucose / Energy Metabolism

    1 BioSystems Pathway for SIK2
        LKB1 signaling events



    SIK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for SIK2 (Q9H0K11, 3 ENSP000003059764) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP250Q9BV731, 3EBI-1181664,EBI-1053100 I2D: score=1 
    CETN3O151823, ENSP000002831224I2D: score=1 STRING: ENSP00000283122
    PPP2R1BP301543, ENSP000003113444I2D: score=1 STRING: ENSP00000311344
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    IRS1P355683, ENSP000003048954I2D: score=1 STRING: ENSP00000304895
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14976552
    GO:0007243intracellular protein kinase cascade IDA14976552
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0046626regulation of insulin receptor signaling pathway ISS--
    GO:0046777protein autophosphorylation IDA18348280

    SIK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SIK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIK2

    1 HMDB Compound for SIK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/23 Novoseek inferred chemical compound relationships for SIK2 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 72.2 6 14659794 (1), 17897103 (1), 18358890 (1), 19243022 (1) (see all 6)
    phosphatidylinositol 54.3 8 18162507 (1), 12648218 (1), 15940250 (1), 16563718 (1) (see all 6)
    ly294002 48.8 5 12648218 (1), 18358890 (1), 19243022 (1), 17324121 (1) (see all 5)
    sb 203580 42.9 1 18358890 (1)
    tyrosine 34.4 3 15312177 (1), 19747165 (1), 10501181 (1)
    wortmannin 29.9 1 12648218 (1)
    phosphoinositide 23.7 3 19747165 (1), 17324121 (1), 12844349 (1)
    manganese superoxide 22.1 1 17309078 (1)
    genistein 15.7 3 19427779 (2), 10501181 (1)
    acth 15 2 19052254 (1)

    Search CenterWatch for drugs/clinical trials and news about SIK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIK2 gene: 
    NM_015191.1  

    Unigene Cluster for SIK2:

    Salt-inducible kinase 2
    Hs.269128  [show with all ESTs]
    Unigene Representative Sequence: AB096248
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304987(uc001plt.3) ENST00000533868
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIK2
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK2 (see all 74):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3916 hsa-miR-3162-5p hsa-miR-637 hsa-miR-200b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSIK2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIK2

    Additional mRNA sequence: 

    AB018324.3 AB084424.1 AB096248.1 AK000396.1 AK291233.1 AL136764.2 BC013612.1 BC078150.1 
    BC113459.1 BC117183.1 EF491816.1 

    10 DOTS entries:

    DT.454694  DT.99949220  DT.91649581  DT.75156510  DT.95166387  DT.97803745  DT.120739411  DT.92428341 
    DT.95352566  DT.92428337 

    24/197 AceView cDNA sequences (see all 197):

    BU683122 BF224023 BC078150 BX098212 NM_015191 W88541 AB084424 AA419562 
    BX283125 CB124295 BU508910 BE222499 AI206017 CA447007 BU158577 AB018324 
    AA724734 CR611247 Z45065 AA928371 CB128233 AL136764 BM728826 BU075766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTTCCA
    SIK2 Expression
    About this image


    See SIK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIK2

    SOURCE GeneReport for Unigene cluster: Hs.269128
        SABiosciences Custom PCR Arrays for SIK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SIK2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sik21 , 5 salt inducible kinase 21, 5 88.95(n)1
    91.55(a)1
      9 (27.75 cM)5
    2353441  NM_178710.31  NP_848825.21 
     508928015 
    chicken
    (Gallus gallus)
    Aves SIK21 salt-inducible kinase 2 75.25(n)
    78.92(a)
      768557  XM_001231563.2  XP_001231564.2 
    lizard
    (Anolis carolinensis)
    Reptilia SIK26
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343521.1(84621-143399)
    zebrafish
    (Danio rerio)
    Actinopterygii sik2b1 salt-inducible kinase 2b 65.53(n)
    69.74(a)
      567919  XM_691233.5  XP_696325.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sik26
    Salt-inducible kinase 2
    24(a)
    1 → many
    X(1949343-1955948)


    ENSEMBL Gene Tree for SIK2 (if available)
    TreeFam Gene Tree for SIK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIK2 gene
    NUAK12  MARK12  PRKAA22  SNRK2  SIK32  PRKAA12  NUAK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    11 SIMAP similar genes for SIK2 using alignment to 1 protein entry:     SIK2_HUMAN:
    PRKAA1    PRKAA2    TSSK1    TSSK1B    TSSK3    SIK1
    PRKACG    CAMK1    PIM3    SIK3    KIAA0999

    SIK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SIK2
    PGOHUM00000237932


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2100 SNPs in SIK2 are shown (see all 2100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471714461,2
    --107395542(+) GGGTAA/GTGTCG 1 -- us2k10--------
    rs5428311,2
    C,F,A,H--107395587(+) ACCCTA/TTATCA 1 -- us2k116Minor allele frequency- T:0.35NS EA NA WA CSA 819
    rs1812170341,2
    --107395894(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1865271091,2
    --107396198(+) GGTAAC/GGGGGG 1 -- us2k10--------
    rs1449935211,2
    C--107396549(+) TGGGG-/AAAAAA 1 -- us2k10--------
    rs17847761,2
    C,F,O,A,H--107396587(-) ACTCTA/GAAAAA 1 -- us2k122Minor allele frequency- G:0.37MN NS EA NA WA 2530
    rs17847751,2
    C,F,A,H--107396655(-) TGCTTG/ATGTGA 1 -- us2k1 tfbs321Minor allele frequency- A:0.39NS EA NA WA 2348
    rs1909946041,2
    --107396778(+) AGTCTA/GTAAGC 1 -- us2k10--------
    rs1448542991,2
    --107396784(+) TAAGCC/GACTGC 1 -- us2k10--------
    rs1475067511,2
    --107396796(+) CTGCTA/GTCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIK2 (111473115 - 111601577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SIK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745076CNV Deletion23290073
    nsv832269CNV Loss17160897
    nsv510273CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing SIK2:
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing SIK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SIK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608973    OMIM disorders: --

    20/26 diseases for SIK2 (see all 26):    About MalaCards
    diffuse large b-cell lymphoma    behcet's disease    malignant mesothelioma    tetanus
    b-cell lymphomas    insulin resistance    gingivitis    intrahepatic cholangiocarcinoma
    pancreatic cancer    cholangiocarcinoma    colon cancer    multiple myeloma
    endometriosis    myeloma    chronic lymphocytic leukemia    infertility
    endotheliitis    retinoblastoma    astrocytoma    pancreatitis


    SIK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for SIK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 26.8 2 19625696 (1), 20215549 (1)
    tumors 20.6 4 17699110 (1), 19843666 (1), 15067358 (1)
    insulin resistance 13.5 2 12624099 (1), 15134808 (1)
    breast cancer 11.7 1 19427779 (1)
    necrosis 10.8 1 17309078 (1)
    pancreatic cancer 5.93 1 19887609 (1)
    cardiovascular diseases 0 1 15662222 (1)
    colon cancer 0 1 12566304 (1)
    retinoblastoma 0 2 19816090 (1), 20074079 (1)

    Genetic Association Database (GAD): SIK2
    Human Genome Epidemiology (HuGE) Navigator: SIK2 (1 document)

    Export disorders for SIK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIK2 gene, integrated from 9 sources (see all 181):
    (articles sorted by number of sources associating them with SIK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PubMed id 15067358)1, 3, 9 Katoh M. and Katoh M. (2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
    4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    9. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt- inducible kinase-2. (PubMed id 12624099)1, 9 Horike N.... Okamoto M. (2003)
    10. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PubMed id 20367563)1, 9 Nagel S....Macleod R.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23235 HGNC: 21680 AceView: SIK2 Ensembl:ENSG00000170145 euGenes: HUgn23235
    ECgene: SIK2 H-InvDB: SIK2

    (According to HUGE)
    About This Section
    HUGE: KIAA0781

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIK2 gene:
    Search GeneIP for patents involving SIK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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