SIK2 Gene
protein-coding GIFtS: 56
GCID: GC11P111473
|
|
salt-inducible kinase 2(Previous name: SNF1-like kinase 2 )
(Previous symbol: SNF1LK2)
| |
Aliases
for SIK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Salt-Inducible Kinase 21 2 3 | | SIK-22 3 | | QIK1 2 3 | | EC 2.7.11.13 8 | | SNF1LK21 2 3 | | DKFZp434K11151 | | KIAA07811 3 5 | | Salt-Inducible Protein Kinase 22 | | LOH11CR1I1 2 | | Salt-Inducible Serine/Threonine Kinase 22 | | SNF1-Like Kinase 21 2 | | Serine/Threonine-Protein Kinase SIK22 | | Qin-Induced Kinase2 3 | | EC 2.7.118 | | Serine/Threonine-Protein Kinase SNF1-Like Kinase 22 3 | | |
Export aliases for SIK2 gene to outside databasesPrevious GC identifers: GC11U900483 GC11P111011 GC11P110978 GC11P107397 |
Summaries
for SIK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency ofinsulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specificcoactivators
Gene Wiki entry for SIK2 (SNF1LK2)
|
Genomic Views
for SIK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIK2 gene promoter:
RFX1 C/EBPbeta XBP-1 Nkx2-5 CREB deltaCREB GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1SIK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P111473: view genomic region
(about GC identifiers)
Start:
|
111,473,115 bp from pter |
End:
|
111,601,577 bp from pter |
Size:
|
128,463 bases |
Orientation:
|
plus strand |
|
Proteins
for SIK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase SIK2 Size: 926 amino acids; 103915 Da
Cofactor: Magnesium
Subunit: Interacts with and phosphorylates TORC2/CRTC2
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAA34501.3; Type=Erroneous initiation;
Secondary accessions: B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8Explore the universe of human proteins at neXtProt for SIK2: NX_Q9H0K1
Post-translational modifications:
Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB391
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0K1
4/13 DME Specific Peptides for SIK2 (Q9H0K1) (see all 13)
SIK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056006.1
ENSEMBL proteins: ENSP00000305976
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SIK2 for ontologies About GeneDecksing
SIK2 Antibody Products:
Assay Products for SIK2: |
Protein
Domains /
Families
for SIK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIK2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9H0K1ProtoNet protein and cluster: Q9H0K1 1 Blocks protein family: IPB000449 Ubiquitin-associated domain
UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UBA domain |
Function
for SIK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency ofinsulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specificcoactivatorsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-175Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIK2 (NM_015191) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SIK2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for SIK2:
|
Pathways & Interactions
for SIK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | LKB1 signaling events | | | 2 | Glucose / Energy Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for SIK2
1  BioSystems Pathway for SIK2
SIK2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for SIK2 (Q9H0K11, 3 ENSP000003059764) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SIK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SIK2 for compounds About GeneDecksing
 Browse Tocris compounds for SIK2
1 HMDB Compound for SIK2 About this table
10/23 Novoseek chemical compound relationships for SIK2 gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pd 98,059 |
72.2 |
6 |
14659794 (1), 17897103 (1), 18358890 (1), 19243022 (1) (see all 6) |
| phosphatidylinositol |
54.3 |
8 |
18162507 (1), 12648218 (1), 15940250 (1), 16563718 (1) (see all 6) |
| ly294002 |
48.8 |
5 |
12648218 (1), 18358890 (1), 19243022 (1), 17324121 (1) (see all 5) |
| sb 203580 |
42.9 |
1 |
18358890 (1) |
| tyrosine |
34.4 |
3 |
15312177 (1), 19747165 (1), 10501181 (1) |
| wortmannin |
29.9 |
1 |
12648218 (1) |
| phosphoinositide |
23.7 |
3 |
19747165 (1), 17324121 (1), 12844349 (1) |
| manganese superoxide |
22.1 |
1 |
17309078 (1) |
| genistein |
15.7 |
3 |
19427779 (2), 10501181 (1) |
| acth |
15 |
2 |
19052254 (1) |
Search CenterWatch for drugs/clinical trials and news about SIK2
|
Transcripts
for SIK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIK2 gene: NM_015191.1 Unigene Cluster for SIK2: Salt-inducible kinase 2 Hs.269128 [show with all ESTs]Unigene Representative Sequence: AB0962482 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304987(uc001plt.3) ENST00000533868
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIK2 (NM_015191) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK2 |
Additional cDNA sequence: AB018324.3 AB084424.1 AB096248.1 AK000396.1 AK291233.1 AL136764.2 BC013612.1 BC078150.1 BC113459.1 BC117183.1 EF491816.1 10 DOTS entries: DT.454694 DT.99949220 DT.91649581 DT.75156510 DT.95166387 DT.120739411 DT.97803745 DT.92428341 DT.95352566 DT.92428337 24/197 AceView cDNA sequences (see all 197): AI652873 CK299672 CA442417 BQ011726 AI200111 AA013422 CA394965 BU618496 AA634633 BQ787525 BU683122 BF224023 AI344137 BC078150 BX098212 BE222499 AA419562 CB124295 BU508910 NM_015191 BX283125 AB084424 W88541 BU627028
GeneLoc Exon Structure
|
Expression
for SIK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCTTCCA
About this image
See SIK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIK2
SOURCE GeneReport for Unigene cluster: Hs.269128
SABiosciences Custom PCR Arrays for SIK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2 |
Orthologs
for SIK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SIK2 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SIK21 |
salt-inducible kinase 2 |
75.25(n)
78.92(a) |
|
768557 XM_001231563.2 XP_001231564.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SIK26 |
-- |
68(a) |
1 ↔ 1 |
GL343521.1(84621-143399) |
zebrafish
(Danio rerio) |
Actinopterygii |
sik2b1 |
salt-inducible kinase 2b |
65.53(n)
69.74(a) |
|
567919 XM_691233.5 XP_696325.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG431436Sik26 |
Salt-inducible kinase 2 |
6(a)23(a) |
possible ortholog1 ↔ many |
3R(6090028-6133204) X(1949343-1955948) |
worm
(Caenorhabditis elegans) |
Secernentea |
kin-296 |
Serine/threonine-protein kinase kin-29 |
20(a) |
1 → many |
X(2843996-2852471) |
rice
(Oryza sativa) |
Liliopsida |
-- |
CAMK_KIN1/SNF1/Nim1_like_AMPKh.1 - CAMK includes c... |
23(a) |
possible ortholog |
7(5101510-5106299) |
ENSEMBL Gene Tree for SIK2 (if available)
TreeFam Gene Tree for SIK2 (if available) |
Paralogs
for SIK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIK2 gene
- BRSK12 NUAK12 MARK12 BRSK22 SIK32 SNRK2 NUAK22 MARK22
- NIM12 SIK12 MARK42 MARK32
11 SIMAP similar genes for SIK2 using alignment to 1 protein entry: SIK2_HUMAN:PRKAA1 PRKAA2 TSSK1 TSSK1B TSSK3 SIK1
PRKACG CAMK1 PIM3 SIK3 KIAA0999
SIK2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIK2
PGOHUM00000237932
|
Genomic Variants
for SIK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIK2 (111473115 - 111601577 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIK2: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing SIK2: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIK2 |
|
Disorders
/ Diseases
for SIK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIK2 for disorders About GeneDecksing
OMIM gene information: 608973
OMIM disorders: --
20/31  diseases for SIK2 (see all 31): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas insulin resistance chronic lymphocytic leukemia
malignant mesothelioma intrahepatic cholangiocarcinoma lymphocytic leukemia behcet's disease
multiple myeloma colon cancer tetanus pancreatic cancer
cholangiocarcinoma breast cancer endometrial cancer myeloma
colon carcinoma gingivitis pancreatitis neurodegeneration
9 Novoseek disease relationships for SIK2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SIK2 (1 document)
Export disorders for SIK2 gene to outside databases
|
Publications
for SIK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIK2 gene, integrated from 9 sources (see all 176):
(articles sorted by number of sources associating them with SIK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PubMed id 15067358)1, 3, 9 Katoh M. and Katoh M. (2004)
- The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (2004)
- LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt- inducible kinase-2. (PubMed id 12624099)1, 9 Horike N.... Okamoto M. (2003)
- Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PubMed id 20367563)1, 9 Nagel S....Macleod R.A. (2010)
- Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. (PubMed id 14532992)1, 9 Katoh M. and Katoh M. (2003)
|
External Searches for SIK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIK2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SIK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SIK2 gene:
Search GeneIP for patents involving SIK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIK2 | | | OriGene Protein Over-expression Lysate for SIK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIK2 | | OriGene 3'-UTR Clone for SIK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIK2 | | OriGene Custom Protein Services for SIK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIK2 |
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| | Antibodies & Assays for SIK2 (QIK) |
| | | | Search Tocris compounds for SIK2 |
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 | | | SIK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2 |
|  |  |  | | | | ThermoFisher Antibodies for SIK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK2 |
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