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Aliases for SIK2 Gene

Aliases for SIK2 Gene

  • Salt Inducible Kinase 2 2 3 5
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 2 3 4
  • SNF1-Like Kinase 2 2 3
  • Qin-Induced Kinase 3 4
  • EC 4 61
  • SNF1LK2 3 4
  • SIK-2 3 4
  • QIK 3 4
  • Salt-Inducible Serine/Threonine Kinase 2 3
  • Serine/Threonine-Protein Kinase SIK2 3
  • Salt-Inducible Protein Kinase 2 3
  • Salt-Inducible Kinase 2 4
  • LOH11CR1I 3
  • EC 2.7.11 61
  • KIAA0781 4

External Ids for SIK2 Gene

Previous HGNC Symbols for SIK2 Gene

  • SNF1LK2

Previous GeneCards Identifiers for SIK2 Gene

  • GC11U900483
  • GC11P111011
  • GC11P110978
  • GC11P111473
  • GC11P107397

Summaries for SIK2 Gene

GeneCards Summary for SIK2 Gene

SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Among its related pathways are Glucagon signaling pathway and Glucose / Energy Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LOC102724428.

UniProtKB/Swiss-Prot for SIK2 Gene

  • Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Wiki entry for SIK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK2 Gene

Genomics for SIK2 Gene

Regulatory Elements for SIK2 Gene

Enhancers for SIK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G111764 1.3 ENCODE dbSUPER 20.9 +163.6 163625 3.3 FOXA2 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF202 SP3 SIK2 PPP2R1B ENSG00000255334 ALG9 PIH1D2 LAYN MIR34C MIR34B C11orf88 BTG4
GH11G111622 1.1 ENCODE dbSUPER 23.2 +22.0 22003 2.9 FEZF1 RAD21 RFX5 YY1 SCRT2 RELB IKZF2 CEBPB NFYC GATAD2B SIK2 PPP2R1B PIR32263 GC11P111651
GH11G111559 1.2 Ensembl ENCODE dbSUPER 19.9 -40.8 -40839 3.9 SOX5 SOX13 GATAD2A FOXA2 SAP130 TEAD1 HLF NR2F1 HMG20A PPARG SIK2 LAYN ENSG00000254980 C11orf88 BTG4 MIR34B MIR34C POU2AF1 LOC644277 PPP2R1B
GH11G111776 1.4 Ensembl ENCODE dbSUPER 12.5 +175.5 175489 2.7 HDGF TBP PKNOX1 ATF1 ARID4B SIN3A DMAP1 THRB ZSCAN9 RAD21 PPP2R1B SIK2 LOC644277 POU2AF1 BTG4 MIR34B MIR34C C11orf88 ENSG00000254980 ENSG00000254990
GH11G111630 1.4 Ensembl ENCODE dbSUPER 12 +31.3 31336 6.3 ELF3 FOXA2 ARID4B SIN3A ZSCAN9 RAD21 RARA YY1 SCRT2 FOS SIK2 PPP2R1B GC11P111651 PIR32263
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIK2 on UCSC Golden Path with GeneCards custom track

Promoters for SIK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044878 609 2401 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for SIK2 Gene

111,602,391 bp from pter
111,732,388 bp from pter
129,998 bases
Plus strand

Genomic View for SIK2 Gene

Genes around SIK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK2 Gene

Proteins for SIK2 Gene

  • Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase SIK2
    Protein Accession:
    Secondary Accessions:
    • A8K5B8
    • B0YJ94
    • O94878
    • Q17RV0
    • Q6AZE2
    • Q76N03
    • Q8NCV7
    • Q96CZ8

    Protein attributes for SIK2 Gene

    926 amino acids
    Molecular mass:
    103915 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and phosphorylates TORC2/CRTC2.
    • Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SIK2 Gene

Selected DME Specific Peptides for SIK2 Gene


Post-translational modifications for SIK2 Gene

  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Ubiquitination at Lys692
  • Modification sites at PhosphoSitePlus

Other Protein References for SIK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIK2 (QIK)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SIK2

Domains & Families for SIK2 Gene

Gene Families for SIK2 Gene

Suggested Antigen Peptide Sequences for SIK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK2: view

Function for SIK2 Gene

Molecular function for SIK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-175.
UniProtKB/Swiss-Prot Function:
Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Enzyme Numbers (IUBMB) for SIK2 Gene

Gene Ontology (GO) - Molecular Function for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0005515 protein binding IPI 20708153
GO:0005524 ATP binding IDA 14976552
genes like me logo Genes that share ontologies with SIK2: view
genes like me logo Genes that share phenotypes with SIK2: view

Animal Models for SIK2 Gene

MGI Knock Outs for SIK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIK2

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK2 Gene

Localization for SIK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIK2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with SIK2: view

Pathways & Interactions for SIK2 Gene

genes like me logo Genes that share pathways with SIK2: view

Pathways by source for SIK2 Gene

1 Cell Signaling Technology pathway for SIK2 Gene
1 BioSystems pathway for SIK2 Gene
1 KEGG pathway for SIK2 Gene

SIGNOR curated interactions for SIK2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14976552
GO:0016310 phosphorylation IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:0035556 intracellular signal transduction IDA 14976552
GO:0046626 regulation of insulin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with SIK2: view

Drugs & Compounds for SIK2 Gene

(17) Drugs for SIK2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HG-9-91-01 Pharma Pan-SIK (salt-inducible kinases) inhibitor 0
Magnesium Nutra 0

(8) Additional Compounds for SIK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SIK2 Gene

Compound Action Cas Number
HG-9-91-01 Pan-SIK (salt-inducible kinases) inhibitor 1456858-58-4
genes like me logo Genes that share compounds with SIK2: view

Transcripts for SIK2 Gene

mRNA/cDNA for SIK2 Gene

Unigene Clusters for SIK2 Gene

Salt-inducible kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIK2 Gene

No ASD Table

Relevant External Links for SIK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIK2 Gene

mRNA differential expression in normal tissues according to GTEx for SIK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for SIK2 Gene

This gene is overexpressed in Lung (51.5) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIK2 Gene

Protein tissue co-expression partners for SIK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIK2 Gene:


SOURCE GeneReport for Unigene cluster for SIK2 Gene:


Evidence on tissue expression from TISSUES for SIK2 Gene

  • Liver(4.5)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with SIK2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIK2 Gene

Orthologs for SIK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIK2 34 35
  • 99.89 (n)
(Canis familiaris)
Mammalia SIK2 34 35
  • 89.18 (n)
(Mus musculus)
Mammalia Sik2 34 16 35
  • 88.7 (n)
(Bos Taurus)
Mammalia SIK2 34 35
  • 88.57 (n)
(Monodelphis domestica)
Mammalia SIK2 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SIK2 35
  • 55 (a)
(Gallus gallus)
Aves SIK2 34 35
  • 74.31 (n)
(Anolis carolinensis)
Reptilia SIK2 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sik2 34
  • 70.52 (n)
(Danio rerio)
Actinopterygii sik2b 34 35
  • 65.15 (n)
sik2a 35
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta KP78b 35
  • 32 (a)
Sik3 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea kin-29 35
  • 28 (a)
Species where no ortholog for SIK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK2 Gene

Gene Tree for SIK2 (if available)
Gene Tree for SIK2 (if available)

Paralogs for SIK2 Gene

(11) SIMAP similar genes for SIK2 Gene using alignment to 1 proteins: Pseudogenes for SIK2 Gene

genes like me logo Genes that share paralogs with SIK2: view

Variants for SIK2 Gene

Sequence variations from dbSNP and Humsavar for SIK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000007272 -- 111,689,554(+) TTAGC(A/G)AAGTT intron-variant
rs1000050820 -- 111,641,713(+) TTCCT(C/T)CTTGC intron-variant
rs1000065784 -- 111,634,767(+) TGCCC(C/T)GTCTT intron-variant
rs1000070943 -- 111,713,438(+) CTCTT(A/G)TATAA intron-variant
rs1000114466 -- 111,662,187(+) GAAAC(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIK2 Gene

Variant ID Type Subtype PubMed ID
esv2745076 CNV deletion 23290073
esv3627742 CNV loss 21293372
nsv510273 OTHER sequence alteration 20534489
nsv832269 CNV loss 17160897
nsv975978 CNV duplication 23825009

Variation tolerance for SIK2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK2 Gene

Disorders for SIK2 Gene

Relevant External Links for SIK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIK2 Gene

Publications for SIK2 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 22 64
  2. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. (PMID: 23322770) Yang F.C. … Lee S.C. (J. Biol. Chem. 2013) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PMID: 20367563) Nagel S. … Macleod R.A. (Leuk. Lymphoma 2010) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SIK2 Gene

Sources for SIK2 Gene

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