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SIK2 Gene

protein-coding   GIFtS: 61
GCID: GC11P111473

Salt-Inducible Kinase 2

(Previous name: SNF1-like kinase 2)
(Previous symbol: SNF1LK2)
  Search for SIK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Salt-Inducible Kinase 21 2 3     EC 2.7.11.13 8
SNF1LK21 2 3     KIAA07813 5
SNF1-Like Kinase 21 2     LOH11CR1I2
Qin-Induced Kinase2 3     Salt-Inducible Protein Kinase 22
Serine/Threonine-Protein Kinase SNF1-Like Kinase 22 3     Salt-Inducible Serine/Threonine Kinase 22
QIK2 3     Serine/Threonine-Protein Kinase SIK22
SIK-22 3     EC 2.7.118

External Ids:    HGNC: 216801   Entrez Gene: 232352   Ensembl: ENSG000001701457   OMIM: 6089735   UniProtKB: Q9H0K13   

Export aliases for SIK2 gene to outside databases

Previous GC identifers: GC11U900483 GC11P111011 GC11P110978 GC11P107397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIK2 Gene:
SIK2 (salt-inducible kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1
Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency
of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific
coactivators

Gene Wiki entry for SIK2 (SNF1LK2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIK2 gene promoter:
         RFX1   C/EBPbeta   XBP-1   Nkx2-5   CREB   deltaCREB   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIK2 promoter sequence
   Search Chromatin IP Primers for SIK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

SIK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111473:  view genomic region     (about GC identifiers)

Start:
111,473,115 bp from pter      End:
111,601,577 bp from pter
Size:
128,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK2  
Size: 926 amino acids; 103915 Da
Cofactor: Magnesium
Subunit: Interacts with and phosphorylates TORC2/CRTC2
Sequence caution: Sequence=BAA34501.3; Type=Erroneous initiation;
Secondary accessions: A8K5B8 B0YJ94 O94878 Q17RV0 Q6AZE2 Q76N03 Q8NCV7 Q96CZ8

Explore the universe of human proteins at neXtProt for SIK2: NX_Q9H0K1

Explore proteomics data for SIK2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB391
  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC61
  • Ubiquitination2 at Lys692
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SIK2 (Q9H0K1) (see all 13)
     IIKLYQV  GNFAVVK  HPHIIKL  LYQVMET 


    See SIK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056006.1  
    ENSEMBL proteins: 
     ENSP00000305976  

    SIK2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SIK2

     
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    SIK2 Antibody Products:

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    SIK2 Assay Products:

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    Search eBioscience for ELISAs for SIK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: salt-inducible kinase 2
    QIK subfamily

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR017090 Ser/Thr_kinase_SIK1/2
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9H0K1

    ProtoNet protein and cluster: Q9H0K1

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK2_HUMAN, Q9H0K1
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with SIK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK2_HUMAN, Q9H0K1
    Function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency
    of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific
    coactivators
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-175

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SIK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SIK2:
     Decreased CYP1A1 activity afte  Increased cell death in DLD-1   Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIK2
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    miRNA
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    miRTarBase miRNAs that target SIK2:
    hsa-mir-181a-5p (MIRT047302), hsa-mir-1229-3p (MIRT036375), hsa-mir-125b-5p (MIRT045926)

    Block miRNA regulation of human, mouse, rat SIK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK2 (see all 74):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3916 hsa-miR-3162-5p hsa-miR-637 hsa-miR-200b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSIK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIK2

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIK2_HUMAN, Q9H0K1: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus ----

    Find genes that share ontologies with SIK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIK2 About    
    See pathways by source

    SuperPathContained pathways About
    1LKB1 signaling events
    LKB1 signaling events
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with SIK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SIK2
        Glucose / Energy Metabolism

    1 BioSystems Pathway for SIK2
        LKB1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIK2
    Interactions:

        Search GeneGlobe Interaction Network for SIK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIK2 (Q9H0K11, 3 ENSP000003059764) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP250Q9BV731, 3EBI-1181664,EBI-1053100 I2D: score=1 
    CETN3O151823, ENSP000002831224I2D: score=1 STRING: ENSP00000283122
    PPP2R1BP301543, ENSP000003113444I2D: score=1 STRING: ENSP00000311344
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    IRS1P355683, ENSP000003048954I2D: score=1 STRING: ENSP00000304895
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14976552
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0035556intracellular signal transduction IDA14976552
    GO:0046626regulation of insulin receptor signaling pathway ISS--
    GO:0046777protein autophosphorylation IDA18348280

    Find genes that share ontologies with SIK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIK2

    1 HMDB Compound for SIK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for SIK2 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 72.2 6 14659794 (1), 17897103 (1), 18358890 (1), 19243022 (1) (see all 6)
    phosphatidylinositol 54.3 8 18162507 (1), 12648218 (1), 15940250 (1), 16563718 (1) (see all 6)
    ly294002 48.8 5 12648218 (1), 18358890 (1), 19243022 (1), 17324121 (1) (see all 5)
    sb 203580 42.9 1 18358890 (1)
    tyrosine 34.4 3 15312177 (1), 19747165 (1), 10501181 (1)
    wortmannin 29.9 1 12648218 (1)
    phosphoinositide 23.7 3 19747165 (1), 17324121 (1), 12844349 (1)
    manganese superoxide 22.1 1 17309078 (1)
    genistein 15.7 3 19427779 (2), 10501181 (1)
    acth 15 2 19052254 (1)



    Find genes that share compounds with SIK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIK2 gene: 
    NM_015191.1  

    Unigene Cluster for SIK2:

    Salt-inducible kinase 2
    Hs.269128  [show with all ESTs]
    Unigene Representative Sequence: AB096248
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304987(uc001plt.3) ENST00000533868
    miRNA
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    Block miRNA regulation of human, mouse, rat SIK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK2 (see all 74):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3916 hsa-miR-3162-5p hsa-miR-637 hsa-miR-200b hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidSIK2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SIK2
      QuantiFast Probe-based Assays in human, mouse, rat SIK2

    Additional mRNA sequence: 

    AB018324.3 AB084424.1 AB096248.1 AK000396.1 AK291233.1 AL136764.2 BC013612.1 BC078150.1 
    BC113459.1 BC117183.1 EF491816.1 

    10 DOTS entries:

    DT.454694  DT.99949220  DT.91649581  DT.75156510  DT.95166387  DT.97803745  DT.120739411  DT.92428341 
    DT.95352566  DT.92428337 

    Selected AceView cDNA sequences (see all 197):

    AI344137 NM_015191 W88541 AB084424 AA419562 BX283125 CB124295 BU508910 
    BE222499 AI206017 CA447007 BU158577 AB018324 AA724734 CR611247 Z45065 
    AA928371 CB128233 AL136764 BM728826 BU075766 BQ011726 AA013422 AI200111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTTCCA
    SIK2 Expression
    About this image

    SIK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269128
        Custom PCR Arrays for SIK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SIK2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sik21 , 5 salt inducible kinase 21, 5 88.7(n)1
    90.9(a)1
      9 (27.75 cM)5
    2353441  NM_178710.31  NP_848825.21 
     508928015 
    chicken
    (Gallus gallus)
    Aves SIK21 salt-inducible kinase 2 74.31(n)
    77.87(a)
      768557  XM_001231563.3  XP_001231564.3 
    lizard
    (Anolis carolinensis)
    Reptilia SIK26
    salt-inducible kinase 2
    69(a)
    1 ↔ 1
    GL343521.1(84621-143399)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sik21 salt-inducible kinase 2 70.52(n)
    74.49(a)
      100125196  XM_002932916.2  XP_002932962.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sik2b1 salt-inducible kinase 2b 65.15(n)
    69.17(a)
      567919  XM_691233.6  XP_696325.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta KP78b6
    Sik36
    Salt-inducible kinase 3
    32(a)
    20(a)
    many ↔ many
    many ↔ many
    3R(7172014-7178853)
    2R(14575637-14593310)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-296
    Protein KIN-29 (kin-29) mRNA, complete cds
    28(a)
    1 → many
    X(2844004-2852479) WBGene00002210


    ENSEMBL Gene Tree for SIK2 (if available)
    TreeFam Gene Tree for SIK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIK2 gene
    BRSK12  MARK12  BRSK22  SNRK2  SIK32  MARK22  NIM1K2  SIK12  
    MARK42  MARK32  
    11 SIMAP similar genes for SIK2 using alignment to 1 protein entry:     SIK2_HUMAN:
    PRKAA1    PRKAA2    TSSK1    TSSK1B    TSSK3    SIK1
    PRKACG    CAMK1    PIM3    SIK3    KIAA0999

    Find genes that share paralogs with SIK2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SIK2
    PGOHUM00000237932


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIK2 (see all 2100)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471714461,2
    --107395542(+) GGGTAA/GTGTCG 1 -- us2k10--------
    rs5428311,2
    C,F,A,H--107395587(+) ACCCTA/TTATCA 1 -- us2k116Minor allele frequency- T:0.35NS EA NA WA CSA 819
    rs1812170341,2
    --107395894(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1865271091,2
    --107396198(+) GGTAAC/GGGGGG 1 -- us2k10--------
    rs1449935211,2
    C--107396549(+) TGGGG-/AAAAAA 1 -- us2k10--------
    rs17847761,2
    C,F,O,A,H--107396587(-) ACTCTA/GAAAAA 1 -- us2k122Minor allele frequency- G:0.37MN NS EA NA WA 2530
    rs17847751,2
    C,F,A,H--107396655(-) TGCTTG/ATGTGA 1 -- us2k1 tfbs321Minor allele frequency- A:0.39NS EA NA WA 2348
    rs1909946041,2
    --107396778(+) AGTCTA/GTAAGC 1 -- us2k10--------
    rs1448542991,2
    --107396784(+) TAAGCC/GACTGC 1 -- us2k10--------
    rs1475067511,2
    --107396796(+) CTGCTA/GTCAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIK2 (111473115 - 111601577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SIK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745076CNV Deletion23290073
    nsv832269CNV Loss17160897
    nsv510273CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing SIK2:
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing SIK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SIK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608973    OMIM disorders: --


    Find genes that share disorders with SIK2           About GenesLikeMe

    9 Novoseek inferred disease relationships for SIK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 26.8 2 19625696 (1), 20215549 (1)
    tumors 20.6 4 17699110 (1), 19843666 (1), 15067358 (1)
    insulin resistance 13.5 2 12624099 (1), 15134808 (1)
    breast cancer 11.7 1 19427779 (1)
    necrosis 10.8 1 17309078 (1)
    pancreatic cancer 5.93 1 19887609 (1)
    cardiovascular diseases 0 1 15662222 (1)
    colon cancer 0 1 12566304 (1)
    retinoblastoma 0 2 19816090 (1), 20074079 (1)

    Genetic Association Database (GAD): SIK2
    Human Genome Epidemiology (HuGE) Navigator: SIK2 (1 document)

    Export disorders for SIK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SIK2 gene, integrated from 10 sources (see all 182):
    (articles sorted by number of sources associating them with SIK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PubMed id 15067358)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    2. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. (PubMed id 23322770)1, 2 Yang F.C....Lee S.C. (J. Biol. Chem. 2013)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2 Screaton R.A.... Montminy M. (Cell 2004)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23235 HGNC: 21680 AceView: SIK2 Ensembl:ENSG00000170145 euGenes: HUgn23235
    ECgene: SIK2 H-InvDB: SIK2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0781

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SIK2 gene:
    Search GeneIP for patents involving SIK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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