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SIK1 Gene

protein-coding   GIFtS: 61
GCID: GC21M044836

Salt-Inducible Kinase 1

(Previous name: SNF1-like kinase)
(Previous symbol: SNF1LK)
  See related diseases
at
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Aliases
for SIK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Salt-Inducible Kinase 11 2 3     SIK-12 3
SNF1LK1 2 3 5     EC 2.7.11.13 8
SNF1-Like Kinase1 2     MSK2 5
Myocardial SNF1-Like Kinase1 2     Salt-Inducible Protein Kinase 12
Serine/Threonine-Protein Kinase SNF1-Like Kinase 12 3     Serine/Threonine Protein Kinase2
Serine/Threonine-Protein Kinase SNF1LK2 3     Serine/Threonine-Protein Kinase SIK12
SIK2 3     EC 2.7.118

External Ids:    HGNC: 111421   Entrez Gene: 1500942   Ensembl: ENSG000001421787   OMIM: 6057055   UniProtKB: P570593   

Export aliases for SIK1 gene to outside databases

Previous GC identifers: GC21M043659 GC21M030202


Summaries
for SIK1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIK1 Gene:
SIK1 (salt-inducible kinase 1) is a protein-coding gene. Diseases associated with SIK1 include medullary sponge kidney, and fibromyalgia. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation,
gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.
Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a
key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for
phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a
sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in
intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A
(PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase
activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone
deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required
during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of
CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the
CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic
lipogenesis by phosphorylating and inhibiting SREBF1

Gene Wiki entry for SIK1 (SNF1LK) Gene


Genomic Views
for SIK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIK1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SIK1 promoter sequence
   Search Chromatin IP Primers for SIK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

SIK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M044836:  view genomic region     (about GC identifiers)

Start:
 44,834,395 bp from pter      End:
 44,847,008 bp from pter
Size:
 12,614 bases      Orientation:
 minus strand

Proteins
for SIK1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK1  
Size: 783 amino acids; 84902 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ
Secondary accessions: A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2

Explore the universe of human proteins at neXtProt for SIK1: NX_P57059

Explore proteomics data for SIK1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is
    required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at
    Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it.
    Phosphorylation at Ser-575 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1
    following intracellular sodium concentration leads to activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for SIK1 (P57059) (see all 17)
     HPHIIKL  RITIAQI  FAVVKLA  LYQVMET 


    See SIK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775490.2  
    ENSEMBL proteins: 
     ENSP00000270162  

    SIK1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SIK1
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    Novus Biologicals SIK1 Proteins
    Novus Biologicals SIK1 Lysates
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    Cloud-Clone Corp. Proteins for SIK1

    SIK1 Antibody Products:

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    Search for Antibodies for SIK1 at Abcam
    Cloud-Clone Corp. Antibodies for SIK1
    ThermoFisher Antibodies for SIK1
    LSBio Antibodies in human, mouse, rat for SIK1

    SIK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SIK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIK1
    Cloud-Clone Corp. CLIAs for SIK1

    Domains /
    Families
    for SIK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 IUPHAR Guide to PHARMACOLOGY protein family classification: salt-inducible kinase 1
    QIK subfamily

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR017090 Ser/Thr_kinase_SIK1/2
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P57059

    ProtoNet protein and cluster: P57059

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
    Domain: The RK-rich region determines the subcellular location (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    SIK1 for domains           About GeneDecksing


    Function
    for SIK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK1_HUMAN, P57059
    Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation,
    gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.
    Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a
    key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for
    phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a
    sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in
    intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A
    (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase
    activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone
    deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required
    during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of
    CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the
    CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic
    lipogenesis by phosphorylating and inhibiting SREBF1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in
    response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the
    reversible sodium/calcium exchanger

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16306228
         
    SIK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SIK1:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Sik1):
     no phenotypic analysis 

    SIK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIK1

    miRNA
    Products:            		miRTarBase miRNAs that target SIK1:
    hsa-let-7a-5p (MIRT052414), hsa-mir-32-5p (MIRT028368), hsa-mir-28-5p (MIRT050012)

    Block miRNA regulation of human, mouse, rat SIK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK1 (see all 84):
    hsa-miR-579 hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmid: SIK1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SIK1
    Predesigned siRNA for gene silencing in human, mouse, rat SIK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SIK1

    Clone
    Products:             		 OriGene clones in human, mouse for SIK1 (see all 8)
    OriGene ORF clones in mouse, rat for SIK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIK1 (NM_173354)
    Sino Biological Human cDNA Clone for SIK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SIK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SIK1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK1


    Localization
    for SIK1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIK1_HUMAN, P57059: Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and
    subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16306228
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IEA--

    SIK1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SIK1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1
    2LKB1 signaling events
    		LKB1 signaling events


    1 BioSystems Pathway for SIK1
        LKB1 signaling events



        Pathway & Disease-focused RT2 Profiler PCR Array including SIK1: 
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SIK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIK1 (P570591, 3 ENSP000002701624) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 3, ENSP000003095034EBI-1181640,EBI-347088 I2D: score=4 STRING: ENSP00000309503
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    VAPAQ9P0L03, ENSP000003456564I2D: score=2 STRING: ENSP00000345656
    CRTC2Q53ET03, ENSP000003058734I2D: score=2 STRING: ENSP00000305873
    PRKAA1Q131313, ENSP000003461484I2D: score=1 STRING: ENSP00000346148
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002028regulation of sodium ion transport ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0007049cell cycle IEA--
    GO:0007346regulation of mitotic cell cycle ISS--

    SIK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SIK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIK1

    1 HMDB Compound for SIK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    Transcripts
    for SIK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIK1 gene: 
    NM_173354.3  

    Unigene Cluster for SIK1:

    Salt-inducible kinase 1
    Hs.282113  [show with all ESTs]
    Unigene Representative Sequence: BC038504
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270162(uc002zdf.2) ENST00000478426
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SIK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIK1 (see all 84):
    hsa-miR-579 hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmid: SIK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIK1
    Clone
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    OriGene ORF clones in mouse, rat for SIK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIK1 (NM_173354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIK1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SIK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIK1
      QuantiTect SYBR Green Assays in human, mouse, rat SIK1
      QuantiFast Probe-based Assays in human, mouse, rat SIK1

    Additional mRNA sequence: 

    AB047786.1 AK131076.1 BC038504.1 

    4 DOTS entries:

    DT.100029647  DT.97824099  DT.95202417  DT.91971143 

    Selected AceView cDNA sequences (see all 197):

    BU753855 AW291852 BE465350 T27043 AW183560 CF528907 BE222096 AA252899 
    BF882508 BF882376 AA559039 NM_173354 D45658 AI362466 CB268319 AI700749 
    BQ942884 BE439674 AI126214 AI914628 CD368423 BM822659 BM831383 BM548998 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SIK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                    -                                                                           
    SP2:                                                                                                
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SIK1

    Expression
    for SIK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SIK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGTAT
    SIK1 Expression
    About this image


    SIK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SIK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SIK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282113
        Pathway & Disease-focused RT2 Profiler PCR Array including SIK1: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for SIK1
    OriGene qSTAR qPCR primer pairs in human, mouse for SIK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIK1
    QuantiTect SYBR Green Assays in human, mouse, rat SIK1
    QuantiFast Probe-based Assays in human, mouse, rat SIK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK1

    Orthologs
    for SIK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SIK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sik15 salt inducible kinase 1   --   17 (17.25 cM) 31844250 
    chicken
    (Gallus gallus)    		 Aves SIK16
    		 Gallus gallus salt-inducible kinase 1 (SIK1), mRNA...
    		 67(a)
    		 1 ↔ 1
    		 1(109234442-109247196)
    lizard
    (Anolis carolinensis)    		 Reptilia SIK16
    		 salt-inducible kinase 1
    		 66(a)
    		 1 ↔ 1
    		 3(136952542-136967106)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.73132 Transcribed sequence with moderate similarity to protein more 76.66(n)    AL859124.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-235e18.31 si:ch211-235e18.3 64.38(n)
    66.43(a)    		   553465  NM_001126383.1  NP_001119855.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta KP78a6
    		 KP78a
    		 28(a)
    		 many ↔ many
    		 3R(7172014-7178853)
    worm
    (Caenorhabditis elegans)    		 Secernentea kin-296
    		 Protein KIN-29 (kin-29) mRNA, complete cds
    		 24(a)
    		 1 → many
    		 X(2844004-2852479) WBGene00002210


    ENSEMBL Gene Tree for SIK1 (if available)
    TreeFam Gene Tree for SIK1 (if available)

    Paralogs
    for SIK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIK1 gene
    LOC102724428  BRSK12  MARK12  BRSK22  SNRK2  SIK32  SIK22  MARK22  
    NIM1K2  MARK42  MARK32  
    Selected SIMAP similar genes for SIK1 using alignment to 1 protein entry:     SIK1_HUMAN(see all similar genes):
    PRKAA1    MARK4    NUAK1    NIM1K    PRKAA2    TSSK3
    PSKH2    TSSK1    TSSK1B    TSSK6    PRKACB    CAMK2B
    CDK4    KIN27    PNCK    Par1b    STK17A    TSSK2

    SIK1 for paralogs           About GeneDecksing



    Genomic Variants
    for SIK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIK1 (see all 483)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0410904
    		A metastatic melanoma sample4--see VAR_0410902 G D mis40--------
    VAR_0410894
    		A glioblastoma multiforme sample4--see VAR_0410892 G S mis40--------
    rs1849395281,2
    		--44833964(+) AGCAGC/TGTGTG 1 -- ds50010--------
    rs1881433211,2
    		--44833981(+) TGCTAA/GAAGGT 1 -- ds50010--------
    rs1809428681,2
    		--44834009(+) ACCAGA/GAAATG 1 -- ds50010--------
    rs1838900411,2
    		--44834061(+) GACTCA/GGAGAA 1 -- ds50010--------
    rs123862761,2
    		C,F,H--44834088(+) GTAAGG/AATGGA 1 -- ds50016Minor allele frequency- A:0.01NS EA NA 414
    rs786684031,2
    		C,F--44834101(+) GTGCCG/AGCAGC 1 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1897916731,2
    		--44834187(+) GGCCAC/TCTGTG 1 -- ds50010--------
    rs1511546831,2
    		C--44834284(+) TCCTC-/TT    
       TAAGA    TTTGA     		1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIK1 (44834395 - 44847008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIK1 (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666871CNV Deletion23128226
    esv2421642CNV Duplication20811451
    nsv820461CNV Duplication20802225
    nsv913869CNV Loss21882294
    dgv4759n71CNV Loss21882294
    esv23456CNV Loss19812545
    nsv913831CNV Loss21882294
    dgv4755n71CNV Loss21882294
    dgv4758n71CNV Loss21882294
    nsv459288CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIK1

    Disorders / Diseases
    for SIK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605705    OMIM disorders: --

    UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
  • Note=Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates
    with poor patient outcome in breast cancers (PubMed:19622832)

    • 13 diseases for SIK1:    
    About MalaCards
    medullary sponge kidney    fibromyalgia    nephrocalcinosis    nephrolithiasis
    glioblastoma multiforme    human t-cell leukemia virus type 1    t-cell leukemia    multiple myeloma
    myeloma    cerebritis    hepatitis    breast cancer
    leukemia

    1 disease from the University of Copenhagen DISEASES database for SIK1:
    Fibromyalgia

    SIK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIK1
    Human Genome Epidemiology (HuGE) Navigator: SIK1 (1 document)

    Export disorders for SIK1 gene to outside databases

    Publications
    for SIK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIK1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with SIK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. (PubMed id 7893599)1, 3, 9 Ruiz J.C....Robertson E.J. (Mech. Dev. 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. (PubMed id 19622832)1, 2 Cheng H....Zhao J.J. (Sci. Signal. 2009)
    4. Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. (PubMed id 18348280)1, 2 Hashimoto Y.K.... Takemori H. (J. Cell. Biochem. 2008)
    5. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PubMed id 16306228)1, 2 Al-Hakim A.K.... Alessi D.R. (J. Cell Sci. 2005)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. (PubMed id 16396636)1, 9 Jaleel M....Alessi D.R. (Biochem. J. 2006)
    9. Regulation of SIK1 abundance and stability is critical for myogenesis. (PubMed id 23256157)1 Stewart R....Berdeaux R. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (PubMed id 23577667)1 Tang H.M....Jin D.Y. (Retrovirology 2013)

    External Searches for SIK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SIK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150094 HGNC: 11142 AceView: SNF1LK Ensembl:ENSG00000142178 euGenes: HUgn150094
    ECgene: SIK1 H-InvDB: SIK1

    Other Databases showing SIK1 gene

    (According to HUGE)
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    TryGeneCards Plus    		   --

    Specialized Databases showing SIK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SIK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SIK1 gene:
    Search GeneIP for patents involving SIK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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