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Aliases for SIK1 Gene

Aliases for SIK1 Gene

  • Salt-Inducible Kinase 1 2 3 4
  • SNF1LK 3 4 6
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 1 3 4
  • Serine/Threonine-Protein Kinase SNF1LK 3 4
  • Myocardial SNF1-Like Kinase 2 3
  • SNF1-Like Kinase 2 3
  • EC 2.7.11.1 4 63
  • SIK-1 3 4
  • MSK 3 6
  • SIK 3 4
  • Serine/Threonine-Protein Kinase SIK1 3
  • Serine/Threonine Protein Kinase 3
  • Salt-Inducible Protein Kinase 1 3
  • EC 2.7.11 63

External Ids for SIK1 Gene

Previous HGNC Symbols for SIK1 Gene

  • SNF1LK

Previous GeneCards Identifiers for SIK1 Gene

  • GC21M043659
  • GC21M044836
  • GC21M030202

Summaries for SIK1 Gene

GeneCards Summary for SIK1 Gene

SIK1 (Salt-Inducible Kinase 1) is a Protein Coding gene. Among its related pathways are LKB1 signaling events. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for SIK1 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).

Gene Wiki entry for SIK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK1 Gene

Genomics for SIK1 Gene

Regulatory Elements for SIK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIK1 Gene

Start:
43,414,515 bp from pter
End:
43,427,128 bp from pter
Size:
12,614 bases
Orientation:
Minus strand

Genomic View for SIK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK1 Gene

Proteins for SIK1 Gene

  • Protein details for SIK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57059-SIK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SIK1
    Protein Accession:
    P57059
    Secondary Accessions:
    • A6NC84
    • Q5R2V5
    • Q6ZNL8
    • Q86YJ2

    Protein attributes for SIK1 Gene

    Size:
    783 amino acids
    Molecular mass:
    84902 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ.

neXtProt entry for SIK1 Gene

Proteomics data for SIK1 Gene at MOPED

Post-translational modifications for SIK1 Gene

  • Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it. Phosphorylation at Ser-575 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1 following intracellular sodium concentration leads to activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SIK1 Gene

Gene Families for SIK1 Gene

Suggested Antigen Peptide Sequences for SIK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57059

UniProtKB/Swiss-Prot:

SIK1_HUMAN :
  • P57059
Domain:
  • The RK-rich region determines the subcellular location.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
genes like me logo Genes that share domains with SIK1: view

Function for SIK1 Gene

Molecular function for SIK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).

Enzyme Numbers (IUBMB) for SIK1 Gene

Gene Ontology (GO) - Molecular Function for SIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16306228
genes like me logo Genes that share ontologies with SIK1: view

Phenotypes for SIK1 Gene

genes like me logo Genes that share phenotypes with SIK1: view

Animal Model Products

CRISPR Products

miRNA for SIK1 Gene

miRTarBase miRNAs that target SIK1

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SIK1 Gene

Localization for SIK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK1 Gene

Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIK1 Gene COMPARTMENTS Subcellular localization image for SIK1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16306228
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with SIK1: view

Pathways for SIK1 Gene

SuperPathways for SIK1 Gene

Superpath Contained pathways
1 LKB1 signaling events
genes like me logo Genes that share pathways with SIK1: view

Pathways by source for SIK1 Gene

1 BioSystems pathway for SIK1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SIK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002028 regulation of sodium ion transport ISS --
GO:0006468 protein phosphorylation ISS --
GO:0007049 cell cycle IEA --
GO:0007346 regulation of mitotic cell cycle ISS --
GO:0010830 regulation of myotube differentiation ISS --
genes like me logo Genes that share ontologies with SIK1: view

Compounds for SIK1 Gene

(1) HMDB Compounds for SIK1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with SIK1: view

Transcripts for SIK1 Gene

mRNA/cDNA for SIK1 Gene

(197) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIK1 Gene

Salt-inducible kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3:

Relevant External Links for SIK1 Gene

GeneLoc Exon Structure for
SIK1
ECgene alternative splicing isoforms for
SIK1

Expression for SIK1 Gene

mRNA expression in normal human tissues for SIK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIK1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.4) and Skin - Sun Exposed (Lower leg) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIK1 Gene

SOURCE GeneReport for Unigene cluster for SIK1 Gene Hs.282113

genes like me logo Genes that share expressions with SIK1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SIK1 Gene

Orthologs for SIK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIK1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIK1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sik1 16
Sik1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIK1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIK1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIK1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIK1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7313 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-235e18.3 35
  • 64.38 (n)
  • 66.43 (a)
SIK1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta KP78a 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea kin-29 36
  • 24 (a)
OneToMany
Species with no ortholog for SIK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK1 Gene

ENSEMBL:
Gene Tree for SIK1 (if available)
TreeFam:
Gene Tree for SIK1 (if available)

Paralogs for SIK1 Gene

Paralogs for SIK1 Gene

genes like me logo Genes that share paralogs with SIK1: view

Variants for SIK1 Gene

Sequence variations from dbSNP and Humsavar for SIK1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs3366 -- 43,414,945(-) CACAA(A/C/G/T)TGATT utr-variant-3-prime
rs10340 -- 43,414,927(-) AAAAC(C/T)CCTTC utr-variant-3-prime
rs179327 -- 43,426,734(+) CCGGT(A/C)TCTCC intron-variant
rs229343 -- 43,416,333(+) CAATG(C/T)ACGCG utr-variant-3-prime
rs229344 -- 43,417,202(-) GCTCC(A/T)CGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIK1 Gene

Variant ID Type Subtype PubMed ID
esv2666871 CNV Deletion 23128226
nsv913831 CNV Loss 21882294
nsv913837 CNV Loss 21882294
dgv4755n71 CNV Loss 21882294
dgv4756n71 CNV Loss 21882294
nsv470901 CNV Loss 18288195
dgv4757n71 CNV Gain 21882294
dgv4758n71 CNV Loss 21882294
nsv820461 CNV Duplication 20802225
esv32887 CNV Gain 17666407
dgv720n67 CNV Loss 20364138
dgv535n27 CNV Gain 19166990
nsv913850 CNV Gain 21882294
nsv470902 CNV Gain 18288195
esv23456 CNV Loss 19812545
nsv819251 CNV Loss 19587683
esv2421642 CNV Duplication 20811451
nsv817933 CNV Gain 17921354
nsv516339 CNV Gain+Loss 19592680
dgv4759n71 CNV Loss 21882294
nsv913861 CNV Loss 21882294
dgv4760n71 CNV Loss 21882294
nsv459288 CNV Loss 19166990
nsv913865 CNV Gain 21882294
nsv828898 CNV Loss 20364138
nsv913869 CNV Loss 21882294
dgv721n67 CNV Gain 20364138
nsv828900 CNV Gain 20364138
nsv828901 CNV Gain 20364138
nsv828903 CNV Loss 20364138
nsv828904 CNV Gain 20364138

Relevant External Links for SIK1 Gene

HapMap Linkage Disequilibrium report
SIK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK1 Gene

Disorders for SIK1 Gene

UniProtKB/Swiss-Prot

SIK1_HUMAN
  • Note=Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers (PubMed:19622832). {ECO:0000269 PubMed:19622832}.

(1) University of Copenhagen DISEASES for SIK1 Gene

Relevant External Links for SIK1

Genetic Association Database (GAD)
SIK1
Human Genome Epidemiology (HuGE) Navigator
SIK1
genes like me logo Genes that share disorders with SIK1: view

Publications for SIK1 Gene

  1. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. (PMID: 7893599) Ruiz J.C. … Robertson E.J. (Mech. Dev. 1994) 2 3 23
  2. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. (PMID: 16396636) Jaleel M. … Alessi D.R. (Biochem. J. 2006) 3 23
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano J.M. … Alessi D.R. (EMBO J. 2004) 3 4
  5. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PMID: 16306228) Al-Hakim A.K. … Alessi D.R. (J. Cell Sci. 2005) 3 4

Products for SIK1 Gene

  • Addgene plasmids for SIK1

Sources for SIK1 Gene

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