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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIK1 Gene

protein-coding   GIFtS: 62
GCID: GC21M044836

Salt-Inducible Kinase 1

(Previous name: SNF1-like kinase)
(Previous symbol: SNF1LK)
  See related diseases
at
MalaCards
 

Aliases
for SIK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Salt-Inducible Kinase 11 2 3     SIK-12 3
SNF1LK1 2 3 5     EC 2.7.11.13 8
SNF1-Like Kinase1 2     MSK2 5
Myocardial SNF1-Like Kinase1 2     Salt-Inducible Protein Kinase 12
Serine/Threonine-Protein Kinase SNF1-Like Kinase 12 3     Serine/Threonine Protein Kinase2
Serine/Threonine-Protein Kinase SNF1LK2 3     Serine/Threonine-Protein Kinase SIK12
SIK2 3     EC 2.7.118

External Ids:    HGNC: 111421   Entrez Gene: 1500942   Ensembl: ENSG000001421787   OMIM: 6057055   UniProtKB: P570593   

Export aliases for SIK1 gene to outside databases

Previous GC identifers: GC21M043659 GC21M030202


Summaries
for SIK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for SIK1 Gene: 
SIK1 (salt-inducible kinase 1) is a protein-coding gene. Diseases associated with SIK1 include medullary sponge kidney, and fibromyalgia. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation,
gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.
Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a
key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for
phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a
sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in
intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A
(PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase
activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone
deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required
during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of
CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the
CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic
lipogenesis by phosphorylating and inhibiting SREBF1

Gene Wiki entry for SIK1 (SNF1LK) Gene


Genomic Views
for SIK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIK1 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SIK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

SIK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIK1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M044836:  view genomic region     (about GC identifiers)

Start:
 44,834,395 bp from pter      End:
 44,847,008 bp from pter
Size:
 12,614 bases      Orientation:
 minus strand

Proteins
for SIK1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SIK1  
Size: 783 amino acids; 84902 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ
Subcellular location: Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and
subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ
Secondary accessions: A6NC84 Q5R2V5 Q6ZNL8 Q86YJ2

Explore the universe of human proteins at neXtProt for SIK1: NX_P57059

Explore proteomics data for SIK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is
    required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at
    Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it.
    Phosphorylation at Ser-575 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1
    following intracellular sodium concentration leads to activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57059

    • 4/17 DME Specific Peptides for SIK1 (P57059) (see all 17)
     HPHIIKL  RITIAQI  FAVVKLA  LYQVMET 

    SIK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIK1 Protein Expression
    REFSEQ proteins: NP_775490.2  
    ENSEMBL proteins: 
     ENSP00000270162  

    Human Recombinant Protein Products for SIK1: 
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    Novus Biologicals SIK1 Proteins
    Novus Biologicals SIK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIK1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16306228
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IEA--

    SIK1 for ontologies           About GeneDecksing



    SIK1 Antibody Products: 
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    Abcam antibodies for SIK1
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    LSBio Antibodies in human, mouse, rat for SIK1 

    Assay Products for SIK1: 
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    Cloud-Clone Corp. ELISAs for SIK1 
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    Protein Domains /
    Families
    for SIK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 IUPHAR Guide to PHARMACOLOGY protein family classification: salt-inducible kinase 1 
    QIK subfamily

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR017090 Ser/Thr_kinase_SIK1/2
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P57059

    ProtoNet protein and cluster: P57059

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
    Domain: The RK-rich region determines the subcellular location (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    SIK1 for domains           About GeneDecksing


    Function
    for SIK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIK1_HUMAN, P57059
    Function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation,
    gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression.
    Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a
    key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for
    phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a
    sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in
    intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A
    (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase
    activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone
    deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required
    during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of
    CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the
    CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic
    lipogenesis by phosphorylating and inhibiting SREBF1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in
    response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the
    reversible sodium/calcium exchanger

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16306228
         
    SIK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SIK1:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sik1):
     no phenotypic analysis 

    SIK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIK1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIK1
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK1 (see all 84):
    hsa-miR-579 hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmid: SIK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIK1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SIK1

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of SIK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SIK1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIK1


    Pathways & Interactions
    for SIK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1LKB1 signaling events
    		LKB1 signaling events
    2Selected targets of CREB1
    		Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SIK1
        Selected targets of CREB1


    1 BioSystems Pathway for SIK1
        LKB1 signaling events




    SIK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for SIK1 (P570591, 3 ENSP000002701624) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 3, ENSP000003095034EBI-1181640,EBI-347088 I2D: score=4 STRING: ENSP00000309503
    YWHAEP622583, ENSP000002643354I2D: score=2 STRING: ENSP00000264335
    VAPAQ9P0L03, ENSP000003456564I2D: score=2 STRING: ENSP00000345656
    CRTC2Q53ET03, ENSP000003058734I2D: score=2 STRING: ENSP00000305873
    PRKAA1Q131313, ENSP000003461484I2D: score=1 STRING: ENSP00000346148
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002028regulation of sodium ion transport ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0007049cell cycle IEA--
    GO:0007243intracellular protein kinase cascade ISS--

    SIK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SIK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIK1

    1 HMDB Compound for SIK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about SIK1

    Transcripts
    for SIK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SIK1 gene: 
    NM_173354.3  

    Unigene Cluster for SIK1:

    Salt-inducible kinase 1
    Hs.282113  [show with all ESTs]
    Unigene Representative Sequence: BC038504
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000270162(uc002zdf.2) ENST00000478426
    miRNA
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    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate SIK1 (see all 84):
    hsa-miR-579 hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmid: SIK1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AB047786.1 AK131076.1 BC038504.1 

    4 DOTS entries:

    DT.100029647  DT.97824099  DT.95202417  DT.91971143 

    24/197 AceView cDNA sequences (see all 197):

    D45658 AA252899 BF882508 BE222096 BE465350 AW291852 BF882376 NM_173354 
    BU753855 T27043 AA559039 CF528907 AW183560 BQ772025 BQ771518 CF890802 
    BF433918 BM785980 BU542387 AI292008 BU620446 T27003 AI149367 BQ954307 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SIK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                    -                                                                           
    SP2:                                                                                                
    SP3:                                                                                                


    ECgene alternative splicing isoforms for SIK1

    Expression
    for SIK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIK1 expression in normal human tissues (normalized intensities)      SIK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGTAT
    SIK1 Expression
    About this image


    SIK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Stem Bronchi
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
             brain/midbrain   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   

    See SIK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIK1

    SOURCE GeneReport for Unigene cluster: Hs.282113
        SABiosciences Expression via Pathway-Focused PCR Array including SIK1: 
              Cardiotoxicity in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for SIK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SIK1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sik11 , 5 salt inducible kinase 11, 5 81.3(n)1
    82.38(a)1    		   17 (17.25 cM)5
    176911  NM_010831.21  NP_034961.21 
     318442505 
    chicken
    (Gallus gallus)    		 Aves SIK11 salt-inducible kinase 1 69.62(n)
    69.02(a)    		   395417  NM_204682.1  NP_990013.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SIK16
    		 Uncharacterized protein
    		 66(a)
    		 1 ↔ 1
    		 3(136952542-136967106)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.73132 Transcribed sequence with moderate similarity to protein more 76.66(n)    AL859124.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-235e18.31 si:ch211-235e18.3 64.19(n)
    66.67(a)    		   553465  NM_001126383.1  NP_001119855.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sik26
    		 Salt-inducible kinase 2
    		 21(a)
    		 1 → many
    		 X(1949343-1955948)


    ENSEMBL Gene Tree for SIK1 (if available)
    TreeFam Gene Tree for SIK1 (if available)

    Paralogs
    for SIK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIK1 gene
    NUAK12  MARK12  PRKAA22  SNRK2  SIK32  SIK22  PRKAA12  NUAK22  
    MARK22  NIM12  MARK42  MARK32  
    18/42 SIMAP similar genes for SIK1 using alignment to 1 protein entry:     SIK1_HUMAN(see all similar genes):
    PRKAA1    MARK4    NUAK1    NIM1    PRKAA2    TSSK3
    PSKH2    TSSK1    TSSK1B    TSSK6    PRKACB    CAMK2B
    CDK4    KIN27    PNCK    Par1b    STK17A    TSSK2

    SIK1 for paralogs           About GeneDecksing



    Genomic Variants
    for SIK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/483 SNPs in SIK1 are shown (see all 483)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0410904
    		A metastatic melanoma sample4--see VAR_0410902 G D mis40--------
    VAR_0410894
    		A glioblastoma multiforme sample4--see VAR_0410892 G S mis40--------
    rs1849395281,2
    		--44833964(+) AGCAGC/TGTGTG 1 -- ds50010--------
    rs1881433211,2
    		--44833981(+) TGCTAA/GAAGGT 1 -- ds50010--------
    rs1809428681,2
    		--44834009(+) ACCAGA/GAAATG 1 -- ds50010--------
    rs1838900411,2
    		--44834061(+) GACTCA/GGAGAA 1 -- ds50010--------
    rs123862761,2
    		C,F,H--44834088(+) GTAAGG/AATGGA 1 -- ds50016Minor allele frequency- A:0.01NS EA NA 414
    rs786684031,2
    		C,F--44834101(+) GTGCCG/AGCAGC 1 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1897916731,2
    		--44834187(+) GGCCAC/TCTGTG 1 -- ds50010--------
    rs1511546831,2
    		C--44834284(+) TCCTC-/TT    
       TAAGA    TTTGA     		1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIK1 (44834395 - 44847008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/31 variations for SIK1 (see all 31):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666871CNV Deletion23128226
    esv2421642CNV Duplication20811451
    nsv820461CNV Duplication20802225
    nsv913869CNV Loss21882294
    dgv4759n71CNV Loss21882294
    esv23456CNV Loss19812545
    nsv913831CNV Loss21882294
    dgv4755n71CNV Loss21882294
    dgv4758n71CNV Loss21882294
    nsv459288CNV Loss19166990

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    Disorders / Diseases
    for SIK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 605705    OMIM disorders: --

    UniProtKB/Swiss-Prot: SIK1_HUMAN, P57059
  • Note=Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates
    with poor patient outcome in breast cancers (PubMed:19622832)

    • 7 diseases for SIK1:    About MalaCards
    medullary sponge kidney    fibromyalgia    nephrocalcinosis    nephrolithiasis
    gastric cancer    hepatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SIK1:
    Fibromyalgia

    SIK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIK1
    Human Genome Epidemiology (HuGE) Navigator: SIK1 (1 document)

    Export disorders for SIK1 gene to outside databases

    Publications
    for SIK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIK1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SIK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. (PubMed id 7893599)1, 3, 9 Ruiz J.C....Robertson E.J. (1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. SIK1 couples LKB1 to p53-dependent anoikis and suppre sses metastasis. (PubMed id 19622832)1, 2 Cheng H....Zhao J.J. (2009)
    4. Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. (PubMed id 18348280)1, 2 Hashimoto Y.K....Takemori H. (2008)
    5. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PubMed id 16306228)1, 2 Al-Hakim A.K.... Alessi D.R. (2005)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    8. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. (PubMed id 16396636)1, 9 Jaleel M....Alessi D.R. (2006)
    9. Regulation of SIK1 abundance and stability is critical for myogenesis. (PubMed id 23256157)1 Stewart R....Berdeaux R. (2013)
    10. LKB1 tumor suppressor and salt-inducible kinases negat ively regulate human T-cell leukemia virus type 1 transcription. (PubMed id 23577667)1 Tang H.M....Jin D.Y. (2013)

    External Searches for SIK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SIK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150094 HGNC: 11142 AceView: SNF1LK Ensembl:ENSG00000142178 euGenes: HUgn150094
    ECgene: SIK1 H-InvDB: SIK1

    Other Databases showing SIK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SIK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SIK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SIK1 gene:
    Search GeneIP for patents involving SIK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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