Aliases for SIK1 Gene
Aliases for SIK1 Gene
External Ids for SIK1 Gene
- HGNC: 11142
- Entrez Gene: 150094
- Ensembl: ENSG00000142178
- OMIM: 605705
- UniProtKB: P57059
Previous HGNC Symbols for SIK1 Gene
- SNF1LK
Previous GeneCards Identifiers for SIK1 Gene
- GC21M043659
- GC21M044836
- GC21M030202
Summaries for SIK1 Gene
-
This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016]
GeneCards Summary for SIK1 Gene
SIK1 (Salt Inducible Kinase 1) is a Protein Coding gene. Diseases associated with SIK1 include Epileptic Encephalopathy, Early Infantile, 30 and Early Myoclonic Encephalopathy. Among its related pathways are Circadian rythm related genes and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK1B.
UniProtKB/Swiss-Prot for SIK1 Gene
-
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Additional gene information for SIK1 Gene
- Monarch Initiative
- Search for SIK1 at DataMed
- Search for SIK1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK1 Gene
Genomics for SIK1 Gene
GeneHancer (GH) Regulatory Elements for SIK1 Gene
Promoters and enhancers for SIK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SIK1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SIK1 Gene
Genomic Locations for SIK1 Gene
- chr21:43,414,509-43,427,128
- (GRCh38/hg38)
- Size:
- 12,620 bases
- Orientation:
- Minus strand
- chr21:44,834,395-44,847,008
- (GRCh37/hg19)
Genomic View for SIK1 Gene
Genes around SIK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
SIK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIK1 Gene
Proteins for SIK1 Gene
-
Protein details for SIK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P57059-SIK1_HUMAN
- Recommended name:
- Serine/threonine-protein kinase SIK1
- Protein Accession:
- P57059
- A6NC84
- Q5R2V5
- Q6ZNL8
- Q86YJ2
Protein attributes for SIK1 Gene
- Size:
- 783 amino acids
- Molecular mass:
- 84902 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ.
Protein Expression for SIK1 Gene
Selected DME Specific Peptides for SIK1 Gene
- P57059:
-
- RITIAQI
- LYQVMET
- NLEKIYREVQ
- RRHTLAEV
- HPHIIKL
- EGRRASDTSLTQG
- SYNHFAAIY
- GNFAVVK
- LRQRVLEGRFRIP
- VLYVLVCG
- VAIKIID
- HHIVHRDLKTENLLLD
- GSPPYAAPE
- FAVVKLA
- IIKLYQV
- KGFLGLNKIKG
- IVHRDLK
Post-translational modifications for SIK1 Gene
- Phosphorylated at Thr-182 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39, leading to its activation. Phosphorylation at Thr-182 promotes autophosphorylation at Ser-186, which is required for sustained activity. Autophosphorylation at Ser-186 is maintained by sequential phosphorylation at Thr-182 by GSK3-beta. GSK3-beta cannot initiate phosphorylation at Thr-182, it can only maintain it. Phosphorylation at Ser-575 by PKA promotes translocation to the cytoplasm. Phosphorylation at Thr-322 by CaMK1 following intracellular sodium concentration leads to activation.
Other Protein References for SIK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SIK1
- Novus Biologicals Antibodies for SIK1
-
Abcam antibodies for SIK1
- Invitrogen Antibodies for SIK1
- Search GeneTex for Antibodies for SIK1
-
Custom Antibody ServicesProSci Antibodies for SIK1
Protein Products
-
OriGene Purified Proteins for SIK1
- Search Origene for MassSpec and Protein Over-expression Lysates for SIK1
- Origene Custom Protein Services for SIK1
- antibodies-online: Search results for available SIK1 related products ranked by validation data
- Search GeneTex for Proteins for SIK1
-
Abcam proteins for SIK1
Assay Products
Domains & Families for SIK1 Gene
Gene Families for SIK1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
Protein Domains for SIK1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P57059UniProtKB/Swiss-Prot:
SIK1_HUMAN :- The RK-rich region determines the subcellular location.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
- Domain:
-
- The RK-rich region determines the subcellular location.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
Function for SIK1 Gene
Molecular function for SIK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Enzyme Numbers (IUBMB) for SIK1 Gene
Phenotypes From GWAS Catalog for SIK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | ISS | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IDA | 14976552 |
| GO:0005515 | protein binding | IPI | 16306228 |
| GO:0005524 | ATP binding | ISS | -- |
Phenotypes for SIK1 Gene
- GenomeRNAi human phenotypes for SIK1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Decreased cell proliferation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased simian virus 40 (SV40) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SIK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SIK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SIK1 gene
- Search ViGene Biosciences for SIK1
CRISPR Products
-
OriGene CRISPR knockouts for SIK1
- genomics-online: gRNA clones - Search results for available SIK1 gene related products
- Applied Biological Materials CRISPR for SIK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIK1
- GenScript: Design CRISPR guide RNA sequences for SIK1
miRNA for SIK1 Gene
- miRTarBase miRNAs that target SIK1
-
- hsa-mir-32-5p (MIRT028368)
- hsa-mir-28-5p (MIRT050012)
- hsa-let-7a-5p (MIRT052414)
- hsa-mir-148a-3p (MIRT155749)
- hsa-mir-152-3p (MIRT155756)
- hsa-mir-148b-3p (MIRT155763)
- hsa-mir-6165 (MIRT155871)
- hsa-mir-17-5p (MIRT155884)
- hsa-mir-20a-5p (MIRT155886)
- hsa-mir-93-5p (MIRT155889)
- hsa-mir-106a-5p (MIRT155892)
- hsa-mir-106b-5p (MIRT155897)
- hsa-mir-302a-3p (MIRT155899)
- hsa-mir-302b-3p (MIRT155900)
- hsa-mir-302c-3p (MIRT155901)
- hsa-mir-302d-3p (MIRT155902)
- hsa-mir-372-3p (MIRT155904)
- hsa-mir-373-3p (MIRT155905)
- hsa-mir-20b-5p (MIRT155910)
- hsa-mir-520e (MIRT155916)
- hsa-mir-520a-3p (MIRT155918)
- hsa-mir-526b-3p (MIRT155919)
- hsa-mir-520b (MIRT155921)
- hsa-mir-520c-3p (MIRT155922)
- hsa-mir-519d-3p (MIRT155923)
- hsa-mir-520d-3p (MIRT155924)
- hsa-mir-668-3p (MIRT155947)
- hsa-mir-302e (MIRT155970)
- hsa-mir-3609 (MIRT156002)
- hsa-mir-548ah-5p (MIRT156020)
- hsa-mir-142-3p (MIRT439638)
- hsa-mir-6848-5p (MIRT468041)
- hsa-mir-6846-5p (MIRT468042)
- hsa-mir-4697-5p (MIRT468043)
- hsa-mir-4488 (MIRT468044)
- hsa-mir-1237-5p (MIRT468045)
- hsa-mir-486-3p (MIRT468046)
- hsa-mir-873-5p (MIRT468047)
- hsa-mir-761 (MIRT468048)
- hsa-mir-3619-5p (MIRT468049)
- hsa-mir-214-3p (MIRT468050)
- hsa-mir-6858-3p (MIRT468051)
- hsa-mir-15a-5p (MIRT468052)
- hsa-mir-497-5p (MIRT468053)
- hsa-mir-15b-5p (MIRT468054)
- hsa-mir-424-5p (MIRT468055)
- hsa-mir-195-5p (MIRT468056)
- hsa-mir-6838-5p (MIRT468057)
- hsa-mir-16-5p (MIRT468058)
- hsa-mir-4696 (MIRT492262)
- hsa-mir-130b-3p (MIRT492263)
- hsa-mir-130a-3p (MIRT492264)
- hsa-mir-301a-3p (MIRT492265)
- hsa-mir-301b-3p (MIRT492266)
- hsa-mir-3666 (MIRT492267)
- hsa-mir-4295 (MIRT492268)
- hsa-mir-454-3p (MIRT492269)
- hsa-mir-370-5p (MIRT505639)
- hsa-mir-636 (MIRT546491)
- hsa-mir-616-3p (MIRT546492)
- hsa-mir-6776-3p (MIRT546493)
- hsa-mir-4796-3p (MIRT546494)
- hsa-mir-559 (MIRT546495)
- hsa-mir-548y (MIRT546496)
- hsa-mir-548w (MIRT546497)
- hsa-mir-548o-5p (MIRT546498)
- hsa-mir-548j-5p (MIRT546499)
- hsa-mir-548i (MIRT546500)
- hsa-mir-548d-5p (MIRT546501)
- hsa-mir-548h-5p (MIRT546502)
- hsa-mir-548c-5p (MIRT546503)
- hsa-mir-548bb-5p (MIRT546504)
- hsa-mir-548b-5p (MIRT546505)
- hsa-mir-548ay-5p (MIRT546506)
- hsa-mir-548au-5p (MIRT546507)
- hsa-mir-548as-5p (MIRT546508)
- hsa-mir-548ar-5p (MIRT546509)
- hsa-mir-548aq-5p (MIRT546510)
- hsa-mir-548ap-5p (MIRT546511)
- hsa-mir-548am-5p (MIRT546512)
- hsa-mir-548ak (MIRT546513)
- hsa-mir-548ae-5p (MIRT546514)
- hsa-mir-548ad-5p (MIRT546515)
- hsa-mir-548ab (MIRT546516)
- hsa-mir-548a-5p (MIRT546517)
- hsa-mir-520f-3p (MIRT546518)
- hsa-mir-3939 (MIRT612493)
- hsa-mir-8485 (MIRT612494)
- hsa-mir-4801 (MIRT612495)
- hsa-mir-4731-3p (MIRT612496)
- hsa-mir-3529-3p (MIRT675553)
- hsa-mir-92b-3p (MIRT726576)
- hsa-mir-92a-3p (MIRT726577)
miRNA Products
- Search ViGene Biosciences for SIK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SIK1
- Browse OriGene Inhibitory RNA Products For SIK1
- genomics-online: shRNA clones - Search results for available SIK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SIK1 gene
Clone Products
- Sino Biological Human cDNA Clone for SIK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SIK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SIK1
- genomics-online: cdna clones - Search results for available SIK1 gene related products
- orf clones - Search results for available SIK1 gene related products
- Applied Biological Materials Clones for SIK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SIK1
-
ViGene Biosciences adenoviral particle packaged cDNA for SIK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SIK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SIK1 gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SIK1 Gene
Localization for SIK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIK1 Gene
- Cytoplasm. Nucleus. Note=Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 16306228 |
| GO:0005737 | cytoplasm | ISS | -- |
Pathways & Interactions for SIK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 2 | Glucagon signaling pathway | ||
| 3 | Circadian rythm related genes | ||
| 4 | LKB1 signaling events | ||
| 5 | TGF-beta Signaling Pathway (WikiPathways) | ||
Pathways by source for SIK1 Gene
3 BioSystems pathways for SIK1 Gene
2 Reactome pathways for SIK1 Gene
1 KEGG pathway for SIK1 Gene
Interacting Proteins for SIK1 Gene
Selected Interacting proteins:
ENSP00000270162
P57059-SIK1_HUMAN
for SIK1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002028 | regulation of sodium ion transport | ISS | -- |
| GO:0006468 | protein phosphorylation | ISS | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007346 | regulation of mitotic cell cycle | ISS | -- |
Drugs & Compounds for SIK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Dabrafenib | Approved, Investigational | Pharma | Target, inhibitor | BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase | 92 | |
| Tafinlar | Approved May 2013 | Pharma | 0 | |||
| Magnesium | Approved | Nutra | 0 | |||
| HG-9-91-01 | Pharma | Pan-SIK (salt-inducible kinases) inhibitor | 0 |
(1) ApexBio Compounds for SIK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| HG-9-91-01 | Pan-SIK (salt-inducible kinases) inhibitor | 1456858-58-4 |
Transcripts for SIK1 Gene
mRNA/cDNA for SIK1 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (197) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SIK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SIK1
- genomics-online: gRNA clones - Search results for available SIK1 gene related products
- Applied Biological Materials CRISPR for SIK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIK1
- GenScript: Design CRISPR guide RNA sequences for SIK1
miRNA Products
- Search ViGene Biosciences for SIK1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SIK1
- Browse OriGene Inhibitory RNA Products For SIK1
- genomics-online: shRNA clones - Search results for available SIK1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SIK1 gene
Clone Products
- Sino Biological Human cDNA Clone for SIK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SIK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SIK1
- genomics-online: cdna clones - Search results for available SIK1 gene related products
- orf clones - Search results for available SIK1 gene related products
- Applied Biological Materials Clones for SIK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: |
Expression for SIK1 Gene
mRNA differential expression in normal tissues according to GTEx for SIK1 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.4) and Skin - Sun Exposed (Lower leg) (x5.1).
This gene is overexpressed in Plasma (55.9) and Adipocyte (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SIK1 Gene:
SIK1SOURCE GeneReport for Unigene cluster for SIK1 Gene:
Hs.282113Evidence on tissue expression from TISSUES for SIK1 Gene
- Lung(4.5)
- Spleen(4.3)
- Nervous system(2.9)
- Muscle(2.4)
- Bone marrow(2.3)
- Skin(2.3)
- Adrenal gland(2.2)
- Liver(2.2)
- Kidney(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SIK1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- face
- forehead
- head
- lip
- mouth
- nose
- pharynx
- skull
Thorax:
- chest wall
- diaphragm
- esophagus
- lung
- rib
- rib cage
Abdomen:
- abdominal wall
- intestine
- large intestine
- stomach
Pelvis:
- pelvis
- rectum
Limb:
- digit
- finger
- foot
- hand
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for SIK1
-
OriGene qPCR primer pairs and template standards for SIK1
- genomics-online: primer clones - Search results for available SIK1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SIK1 Gene
Orthologs for SIK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SIK1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Sik1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SIK1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SIK1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SIK1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SIK1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SIK1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SIK1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.7313 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-235e18.3 33 |
|
||
| SIK1 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | KP78a 34 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | kin-29 34 |
|
OneToMany |
- Species where no ortholog for SIK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SIK1 Gene
Paralogs for SIK1 Gene
(42) SIMAP similar genes for SIK1 Gene using alignment to 1 proteins:
Variants for SIK1 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112011493 | likely-benign, Epileptic encephalopathy, early infantile, 30 | 43,420,416(-) | C/T | coding_sequence_variant, missense_variant | |
| rs112660017 | benign, Epileptic encephalopathy, early infantile, 30 | 43,420,276(-) | A/G | coding_sequence_variant, synonymous_variant | |
| rs113379599 | benign, Epileptic encephalopathy, early infantile, 30 | 43,420,300(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs113434279 | benign, Epileptic encephalopathy, early infantile, 30 | 43,418,399(-) | C/A/T | coding_sequence_variant, synonymous_variant | |
| rs113514102 | benign, Epileptic encephalopathy, early infantile, 30 | 43,420,255(-) | C/A | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1274e212 | CNV | gain | 25503493 |
| dgv2398n106 | CNV | deletion | 24896259 |
| dgv535n27 | CNV | gain | 19166990 |
| dgv720n67 | CNV | loss | 20364138 |
| dgv721n67 | CNV | gain | 20364138 |
| dgv7868n54 | CNV | gain | 21841781 |
| dgv7869n54 | CNV | gain | 21841781 |
| dgv7870n54 | CNV | gain | 21841781 |
| dgv7871n54 | CNV | loss | 21841781 |
| dgv97e203 | CNV | gain | 21179565 |
| esv23456 | CNV | loss | 19812545 |
| esv2421642 | CNV | duplication | 20811451 |
| esv2666871 | CNV | deletion | 23128226 |
| esv32887 | CNV | gain | 17666407 |
| nsv1056684 | CNV | gain | 25217958 |
| nsv1073135 | CNV | deletion | 25765185 |
| nsv459288 | CNV | loss | 19166990 |
| nsv470901 | CNV | loss | 18288195 |
| nsv470902 | CNV | gain | 18288195 |
| nsv483099 | CNV | gain | 15286789 |
| nsv516339 | CNV | gain+loss | 19592680 |
| nsv587683 | CNV | loss | 21841781 |
| nsv587684 | CNV | gain | 21841781 |
| nsv817933 | CNV | gain | 17921354 |
| nsv819251 | CNV | loss | 19587683 |
| nsv820461 | CNV | duplication | 20802225 |
| nsv828898 | CNV | loss | 20364138 |
| nsv828900 | CNV | gain | 20364138 |
| nsv828901 | CNV | gain | 20364138 |
| nsv828903 | CNV | loss | 20364138 |
| nsv828904 | CNV | gain | 20364138 |
| nsv953640 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.77;
78.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIK1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK1 Gene
Disorders for SIK1 Gene
(10) MalaCards diseases for SIK1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epileptic encephalopathy, early infantile, 30 |
|
|
| early myoclonic encephalopathy |
|
|
| epileptic encephalopathy, early infantile, 15 |
|
|
| west syndrome |
|
|
| bone lymphoma |
|
|
Search SIK1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SIK1_HUMAN- Epileptic encephalopathy, early infantile, 30 (EIEE30) [MIM:616341]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. {ECO:0000269 PubMed:25839329}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers (PubMed:19622832). {ECO:0000269 PubMed:19622832}.
Additional Disease Information for SIK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for SIK1 Gene
Publications for SIK1 Gene
- Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. (PMID: 7893599) Ruiz JC … Robertson EJ (Mechanisms of development 1994) 2 3 22 58
- De novo mutations in SIK1 cause a spectrum of developmental epilepsies. (PMID: 25839329) Hansen J … Paciorkowski AR (American journal of human genetics 2015) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. (PMID: 19622832) Cheng H … Zhao JJ (Science signaling 2009) 3 4 58
- Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. (PMID: 18348280) Hashimoto YK … Takemori H (Journal of cellular biochemistry 2008) 3 4 58
Products for SIK1 Gene
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- Custom Antibody ServicesOriGene Antibodies for SIK1
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SIK1
- Novus Biologicals proteins and lysates for SIK1
- Novus Biologicals
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- Abcam proteins for SIK1
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- Browse Primary Antibodies
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SIK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for SIK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SIK1
- VectorBuilder custom plasmid, inducible vectors for SIK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SIK1
- antibodies-online: Search results for 105 available SIK1 Antibodies ranked by validation data
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- antibodies-online: Search results for available SIK1 related products ranked by validation data
- Search GeneTex for Antibodies for SIK1
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- ViGene Biosciences adenoviral particle packaged cDNA for SIK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SIK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SIK1 gene
- Search ViGene Biosciences for SIK1
- Custom Antibody ServicesProSci Antibodies for SIK1
- Search for SIK1 Proteins at ProSci
- Horizon Cell Lines for SIK1
- genomics-online: cdna clones - Search results for available SIK1 gene related products
- orf clones - Search results for available SIK1 gene related products
- genomics-online: gRNA clones - Search results for available SIK1 gene related products
- genomics-online: primer clones - Search results for available SIK1 gene related products
- genomics-online: shRNA clones - Search results for available SIK1 gene related products
Sources for SIK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew