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Aliases for SIGLECL1 Gene

Aliases for SIGLECL1 Gene

  • SIGLEC Family Like 1 2 3 5
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 7 2 3
  • C19orf75 3 4
  • Sialic Acid Binding Ig-Like Lectin 23, Pseudogene 2
  • Chromosome 19 Open Reading Frame 75 2
  • SIGLEC Family-Like Protein 1 3
  • SIGLEC23P 3
  • SIGLECP7 3

External Ids for SIGLECL1 Gene

Previous HGNC Symbols for SIGLECL1 Gene

  • C19orf75

Previous GeneCards Identifiers for SIGLECL1 Gene

  • GC19M052625
  • GC19M052355
  • GC19M056670
  • GC19M056686
  • GC19P051761

Summaries for SIGLECL1 Gene

GeneCards Summary for SIGLECL1 Gene

SIGLECL1 (SIGLEC Family Like 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLECL1 Gene

Genomics for SIGLECL1 Gene

Regulatory Elements for SIGLECL1 Gene

Enhancers for SIGLECL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SIGLECL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLECL1 Gene

51,246,348 bp from pter
51,269,330 bp from pter
22,983 bases
Plus strand

Genomic View for SIGLECL1 Gene

Genes around SIGLECL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLECL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLECL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLECL1 Gene

Proteins for SIGLECL1 Gene

  • Protein details for SIGLECL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SIGLEC family-like protein 1
    Protein Accession:

    Protein attributes for SIGLECL1 Gene

    197 amino acids
    Molecular mass:
    21283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIGLECL1 Gene

Post-translational modifications for SIGLECL1 Gene

No Post-translational modifications

Other Protein References for SIGLECL1 Gene

No data available for DME Specific Peptides for SIGLECL1 Gene

Domains & Families for SIGLECL1 Gene

Protein Domains for SIGLECL1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIGLECL1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SIGLECL1 Gene

Function for SIGLECL1 Gene

genes like me logo Genes that share phenotypes with SIGLECL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGLECL1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLECL1 Gene

Localization for SIGLECL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLECL1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SIGLECL1 Gene COMPARTMENTS Subcellular localization image for SIGLECL1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLECL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLECL1: view

Pathways & Interactions for SIGLECL1 Gene

SuperPathways for SIGLECL1 Gene

No Data Available

Interacting Proteins for SIGLECL1 Gene

Gene Ontology (GO) - Biological Process for SIGLECL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SIGLECL1 Gene

Drugs & Compounds for SIGLECL1 Gene

No Compound Related Data Available

Transcripts for SIGLECL1 Gene


(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLECL1 Gene

SIGLEC family like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLECL1 Gene

No ASD Table

Relevant External Links for SIGLECL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLECL1 Gene

mRNA expression in normal human tissues for SIGLECL1 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLECL1 Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for SIGLECL1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLECL1 Gene

Protein tissue co-expression partners for SIGLECL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIGLECL1 Gene:


SOURCE GeneReport for Unigene cluster for SIGLECL1 Gene:

genes like me logo Genes that share expression patterns with SIGLECL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SIGLECL1 Gene

Orthologs for SIGLECL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLECL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SIGLECL1 34
  • 80.95 (n)
  • 67.72 (a)
  • 67 (a)
(Mus musculus)
Mammalia Gm2511 34
  • 71.43 (n)
  • 59.79 (a)
Gm2511 16
4931406B18Rik 35
  • 21 (a)
(Pan troglodytes)
Mammalia SIGLECL1 34
  • 99.15 (n)
  • 98.48 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Siglecl1 34
  • 70.68 (n)
  • 57.59 (a)
(Bos Taurus)
Mammalia SIGLECL1 35
  • 61 (a)
Species where no ortholog for SIGLECL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLECL1 Gene

Gene Tree for SIGLECL1 (if available)
Gene Tree for SIGLECL1 (if available)

Paralogs for SIGLECL1 Gene

(3) SIMAP similar genes for SIGLECL1 Gene using alignment to 4 proteins: Pseudogenes for SIGLECL1 Gene

genes like me logo Genes that share paralogs with SIGLECL1: view

No data available for Paralogs for SIGLECL1 Gene

Variants for SIGLECL1 Gene

Sequence variations from dbSNP and Humsavar for SIGLECL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425668 -- 51,255,610(+) aaccc(A/T)attaa intron-variant, upstream-variant-2KB
rs10439117 -- 51,259,238(+) GATGA(A/C)aattg intron-variant
rs10853828 -- 51,263,143(+) TGATA(G/T)CCAGT intron-variant, upstream-variant-2KB
rs11084064 -- 51,261,577(+) gccac(C/T)gctcc intron-variant
rs11084065 -- 51,263,163(+) AATTG(A/G)TCATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIGLECL1 Gene

Variant ID Type Subtype PubMed ID
nsv1060026 CNV gain 25217958
nsv1123274 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv518134 CNV loss 19592680
nsv519982 CNV loss 19592680
nsv819924 CNV loss 19587683

Variation tolerance for SIGLECL1 Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLECL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLECL1 Gene

Disorders for SIGLECL1 Gene

Relevant External Links for SIGLECL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIGLECL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLECL1 Gene

Publications for SIGLECL1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65
  5. A second uniquely human mutation affecting sialic acid biology. (PMID: 11546777) Angata T. … Varki A. (J. Biol. Chem. 2001) 3 65

Products for SIGLECL1 Gene

Sources for SIGLECL1 Gene

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