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SIGLEC9 Gene

protein-coding   GIFtS: 52
GCID: GC19P051628

Sialic Acid Binding Ig-Like Lectin 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 91 2     OBBP-LIKE2
Protein FOAP-92 3     Sialic Acid-Binding Ig-Like Lectin 92
CDw3292 3     siglec-92
CD3292     Siglec-93
FOAP-92     CD329 Antigen3

External Ids:    HGNC: 108781   Entrez Gene: 271802   Ensembl: ENSG000001294507   OMIM: 6056405   UniProtKB: Q9Y3363   

Export aliases for SIGLEC9 gene to outside databases

Previous GC identifers: GC19P052258 GC19P051989 GC19P056304 GC19P056319 GC19P047961


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC9 Gene:
SIGLEC9 (sialic acid binding Ig-like lectin 9) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIGL9_HUMAN, Q9Y336
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC9 gene promoter:
         AP-1   HOXA3   AML1a   STAT5A   N-Myc   PPAR-gamma1   ARP-1   STAT3   PPAR-gamma2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC9 promoter sequence
   Search Chromatin IP Primers for SIGLEC9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3-q13.4

SIGLEC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051628:  view genomic region     (about GC identifiers)

Start:
51,628,137 bp from pter      End:
51,639,908 bp from pter
Size:
11,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIGL9_HUMAN, Q9Y336 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 9 precursor  
Size: 463 amino acids; 50082 Da
Secondary accessions: Q6GTU4 Q9BYI9

Explore the universe of human proteins at neXtProt for SIGLEC9: NX_Q9Y336

Explore proteomics data for SIGLEC9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn101, Asn138, Asn161, Asn225, Asn231, Asn238, Asn256, Asn334
  • Modification sites at PhosphoSitePlus

  • See SIGLEC9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001185487.1  NP_055256.1  

    ENSEMBL proteins: 
     ENSP00000250360   ENSP00000413861   ENSP00000472483  

    SIGLEC9 Human Recombinant Protein Products:

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    antibodies-online proteins for SIGLEC9 (3 products) 

     
    antibodies-online peptides for SIGLEC9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9Y336

    ProtoNet protein and cluster: Q9Y336

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: SIGL9_HUMAN, Q9Y336
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIGLEC9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL9_HUMAN, Q9Y336
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
    with sialic acids on the same cell surface

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding NAS10801860
         
    Find genes that share ontologies with SIGLEC9           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SIGLEC9:
     Increased S DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SIGLEC9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIGL9_HUMAN, Q9Y336: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS10801860

    Find genes that share ontologies with SIGLEC9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC9
    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC9

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SIGLEC9 (Q9Y3363 ENSP000002503604) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIFAP3Q928453I2D: score=1 
    PTPN6P293503I2D: score=1 
    SIRPAENSP000003483074STRING: ENSP00000348307
    TAPBPLENSP000002665564STRING: ENSP00000266556
    IGSF11ENSP000003773704STRING: ENSP00000377370
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway NAS10801860

    Find genes that share ontologies with SIGLEC9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC9 (SIGL9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC9 gene (2 alternative transcripts): 
    NM_001198558.1  NM_014441.2  

    Unigene Cluster for SIGLEC9:

    Sialic acid binding Ig-like lectin 9
    Hs.245828  [show with all ESTs]
    Unigene Representative Sequence: NM_014441
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250360(uc002pvu.3) ENST00000440804(uc010yct.2) ENST00000599948

    miRNA
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    Additional mRNA sequence: 

    AB026265.1 AF227924.1 AF247180.1 AK297043.1 AK315272.1 AY358913.1 BC035365.1 

    2 DOTS entries:

    DT.40300295  DT.95369040 

    Selected AceView cDNA sequences (see all 26):

    BG483747 NM_014441 AF227924 CB156435 BP347306 BU622649 AW139840 AY358913 
    CA430269 AA936059 BU688064 BI822560 BC035365 BI548551 AF247180 AB026265 
    AW137995 CB529980 BI909956 AW131386 CD691800 BG540675 BI907683 BX345663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTCTTCC
    SIGLEC9 Expression
    About this image

    SIGLEC9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.245828

    UniProtKB/Swiss-Prot: SIGL9_HUMAN, Q9Y336
    Tissue specificity: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils).
    Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain,
    stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small
    intestine and spinal cordon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIGLEC9 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglece1 sialic acid binding Ig-like lectin E 66.97(n)
    54.63(a)
      83382  NM_031181.2  NP_112458.2 


    ENSEMBL Gene Tree for SIGLEC9 (if available)
    TreeFam Gene Tree for SIGLEC9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC9 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  
    MAG2  SIGLEC102  SIGLEC72  
    10 SIMAP similar genes for SIGLEC9 using alignment to 2 protein entries:     SIGL9_HUMAN (see all proteins):
    SIGLEC12    SIGLEC7    SIGLEC8    SIGLEC6    SIGLEC14    SIGLEC16
    SIGLEC11    SIGLEC10    CD33    SIGLEC5

    Find genes that share paralogs with SIGLEC9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC9 (see all 412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104195151,2
    C,F,H--51626152(+) GGGACG/AGAGGA 2 -- us2k18Minor allele frequency- A:0.17NS EA WA CSA 540
    rs104193471,2
    C,F--51626231(+) AGTTGC/TAGGAC 2 -- us2k1 tfbs34Minor allele frequency- T:0.40WA CSA 124
    rs10394051,2
    C,F,A--51626237(+) AGGACG/AGCTGC 2 -- us2k116Minor allele frequency- A:0.35NA EA WA CSA 736
    rs569850521,2
    C,F--51626425(+) GGCTTC/GCCCCC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs760091821,2
    C,F--51626514(+) CCCGAG/ATTCCA 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1809420101,2
    --51626787(+) AAACAC/TGGGGG 2 -- us2k10--------
    rs104208611,2
    C,F--51626790(+) CATGGG/CGGCCT 2 -- us2k15Minor allele frequency- C:0.40NA WA CSA 126
    rs1405481721,2
    C--51626806(+) ATTCAC/TGGCAA 2 -- us2k10--------
    rs601331221,2
    C,F--51626922(+) GGTAAC/AAAAGA 2 -- us2k13Minor allele frequency- A:0.40WA 122
    rs1444062021,2
    --51626939(+) GTTGCA/GGCATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIGLEC9 (51628137 - 51639908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SIGLEC9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34104CNV Loss18971310
    nsv912292CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605640    OMIM disorders: --


    Find genes that share disorders with SIGLEC9           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SIGLEC9 (1 document)

    Export disorders for SIGLEC9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC9 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SIGLEC9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). (PubMed id 10903842)1, 2, 3 Foussias G.... Diamandis E.P. (Genomics 2000)
    2. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. (PubMed id 10801862)1, 2, 9 Zhang J.Q.... Crocker P.R. (J. Biol. Chem. 2000)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co- evolution with sialic acid synthesis pathways. (PubMed id 10801860)1, 2 Angata T. and Varki A. (J. Biol. Chem. 2000)
    6. Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation. (PubMed id 24145038)1 Sabit I....Furukawa K. (J. Biol. Chem. 2013)
    7. Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of I^-catenin and subsequent cell growth. (PubMed id 24045940)1 Tanida S....Nakada H. (J. Biol. Chem. 2013)
    8. A novel function of Siglec-9 A391C polymorphism on T cell receptor signaling. (PubMed id 20733319)1 Cheong K.A....Lee A.Y. (Int. Arch. Allergy Immunol. 2011)
    9. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. (PubMed id 21821708)1 Aalto K....Jalkanen S. (Blood 2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27180 HGNC: 10878 AceView: SIGLEC9 Ensembl:ENSG00000129450 euGenes: HUgn27180
    ECgene: SIGLEC9 H-InvDB: SIGLEC9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SIGLEC9 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_275

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC9 gene:
    Search GeneIP for patents involving SIGLEC9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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