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Aliases for SIGLEC9 Gene

Aliases for SIGLEC9 Gene

  • Sialic Acid Binding Ig Like Lectin 9 2 3 5
  • Protein FOAP-9 3 4
  • Siglec-9 3 4
  • CDw329 3 4
  • Sialic Acid Binding Ig-Like Lectin 9 2
  • Sialic Acid-Binding Ig-Like Lectin 9 3
  • CD329 Antigen 4
  • OBBP-LIKE 3
  • FOAP-9 3
  • CD329 3

External Ids for SIGLEC9 Gene

Previous GeneCards Identifiers for SIGLEC9 Gene

  • GC19P052258
  • GC19P051989
  • GC19P056304
  • GC19P056319
  • GC19P051628
  • GC19P047961

Summaries for SIGLEC9 Gene

GeneCards Summary for SIGLEC9 Gene

SIGLEC9 (Sialic Acid Binding Ig Like Lectin 9) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC7.

UniProtKB/Swiss-Prot for SIGLEC9 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC9 Gene

Genomics for SIGLEC9 Gene

Regulatory Elements for SIGLEC9 Gene

Enhancers for SIGLEC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051121 1.6 FANTOM5 Ensembl ENCODE 18.5 +2.7 2667 11.7 PKNOX1 ATF1 YBX1 YY1 GATA2 ELK1 FOS JUNB NCOA1 REST SIGLEC9 SIGLEC18P SIGLEC10 C19orf81 SIGLEC17P KLK11 SIGLEC7 CD33 SIGLEC12 ENSG00000267990
GH19F051134 1.4 FANTOM5 Ensembl ENCODE 11.5 +15.2 15221 10.6 TBP PKNOX1 NFRKB BCLAF1 KDM4B SMAD5 ZBTB11 GTF2B CEBPB ELF1 SIGLEC17P POLD1 CTU1 SIGLEC9 ZNF616 KLK14 KLK10 SIGLEC7 SIGLEC10 CD33
GH19F051393 1.5 FANTOM5 ENCODE 4.3 +270.2 270168 2.8 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A ZNF143 FOS KLF13 ZNF616 ZNF577 ZNF766 ZNF432 ZNF841 ZNF836 ZNF175 CTU1 ZNF350 C19orf84
GH19F051106 1.1 ENCODE 5.6 -16.8 -16776 2.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF175 ZNF615 CTU1 SIGLEC9 SIGLEC14 PIR34748
GH19F051115 0.6 Ensembl ENCODE 6.7 -9.8 -9780 2.6 PRDM1 SIGLEC9 SIGLEC18P CTU1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIGLEC9 on UCSC Golden Path with GeneCards custom track

Promoters for SIGLEC9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818598 20 201 ZNF316 MAFG EMSY MAFK NR2F2
ENSR00001818599 1020 1401 YBX1 MNT FOXA1 NR2F2 ZKSCAN1 ZFP41 ZNF316 ZNF658 HDAC2 KDM1A

Genomic Location for SIGLEC9 Gene

Chromosome:
19
Start:
51,124,880 bp from pter
End:
51,141,020 bp from pter
Size:
16,141 bases
Orientation:
Plus strand

Genomic View for SIGLEC9 Gene

Genes around SIGLEC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC9 Gene

Proteins for SIGLEC9 Gene

  • Protein details for SIGLEC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y336-SIGL9_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 9
    Protein Accession:
    Q9Y336
    Secondary Accessions:
    • Q6GTU4
    • Q9BYI9

    Protein attributes for SIGLEC9 Gene

    Size:
    463 amino acids
    Molecular mass:
    50082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC9 Gene

Post-translational modifications for SIGLEC9 Gene

  • Glycosylation at Asn 101, Asn 138, Asn 161, Asn 225, Asn 231, Asn 238, Asn 256, and Asn 334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIGLEC9 Gene

Domains & Families for SIGLEC9 Gene

Protein Domains for SIGLEC9 Gene

Suggested Antigen Peptide Sequences for SIGLEC9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y336

UniProtKB/Swiss-Prot:

SIGL9_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC9: view

Function for SIGLEC9 Gene

Molecular function for SIGLEC9 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Ontology (GO) - Molecular Function for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding NAS 10801860
genes like me logo Genes that share ontologies with SIGLEC9: view
genes like me logo Genes that share phenotypes with SIGLEC9: view

Animal Models for SIGLEC9 Gene

MGI Knock Outs for SIGLEC9:

Animal Model Products

miRNA for SIGLEC9 Gene

miRTarBase miRNAs that target SIGLEC9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC9 Gene

Localization for SIGLEC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC9 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10801860
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC9: view

Pathways & Interactions for SIGLEC9 Gene

genes like me logo Genes that share pathways with SIGLEC9: view

Interacting Proteins for SIGLEC9 Gene

Gene Ontology (GO) - Biological Process for SIGLEC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway NAS 10801860
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC9: view

No data available for SIGNOR curated interactions for SIGLEC9 Gene

Transcripts for SIGLEC9 Gene

Unigene Clusters for SIGLEC9 Gene

Sialic acid binding Ig-like lectin 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC9 Gene

No ASD Table

Relevant External Links for SIGLEC9 Gene

GeneLoc Exon Structure for
SIGLEC9
ECgene alternative splicing isoforms for
SIGLEC9

Expression for SIGLEC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC9 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC9 Gene

This gene is overexpressed in Whole Blood (x29.1) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for SIGLEC9 Gene

This gene is overexpressed in Monocytes (43.5) and Peripheral blood mononuclear cells (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC9 Gene



Protein tissue co-expression partners for SIGLEC9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC9 Gene:

SIGLEC9

SOURCE GeneReport for Unigene cluster for SIGLEC9 Gene:

Hs.245828

mRNA Expression by UniProt/SwissProt for SIGLEC9 Gene:

Q9Y336-SIGL9_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
genes like me logo Genes that share expression patterns with SIGLEC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC9 Gene

Orthologs for SIGLEC9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC9 34
  • 98.16 (n)
SIGLEC13 35
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglece 34 16 35
  • 66.97 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 49 (a)
OneToMany
Species where no ortholog for SIGLEC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC9 Gene

ENSEMBL:
Gene Tree for SIGLEC9 (if available)
TreeFam:
Gene Tree for SIGLEC9 (if available)

Paralogs for SIGLEC9 Gene

(10) SIMAP similar genes for SIGLEC9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC9: view

Variants for SIGLEC9 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1039405 -- 51,122,980(+) AGGAC(A/G)GCTGC upstream-variant-2KB
rs10402313 -- 51,130,626(+) CATCT(C/G)CCCAC intron-variant
rs10418752 -- 51,133,341(+) gctga(A/G)gtggg intron-variant
rs10419347 -- 51,122,974(+) AGTTG(C/T)AGGAC upstream-variant-2KB
rs10419515 -- 51,122,895(+) GGGAC(A/G)GAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC9 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259
esv34104 CNV loss 18971310

Variation tolerance for SIGLEC9 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC9 Gene

Disorders for SIGLEC9 Gene

Relevant External Links for SIGLEC9

Human Genome Epidemiology (HuGE) Navigator
SIGLEC9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC9

No disorders were found for SIGLEC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC9 Gene

Publications for SIGLEC9 Gene

  1. Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). (PMID: 10903842) Foussias G. … Diamandis E.P. (Genomics 2000) 2 3 4 64
  2. Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. (PMID: 10801862) Zhang J.Q. … Crocker P.R. (J. Biol. Chem. 2000) 3 4 22 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co- evolution with sialic acid synthesis pathways. (PMID: 10801860) Angata T. … Varki A. (J. Biol. Chem. 2000) 3 4 64

Products for SIGLEC9 Gene

Sources for SIGLEC9 Gene

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