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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGLEC8 Gene

protein-coding   GIFtS: 52
GCID: GC19M051956

sialic acid binding Ig-like lectin 8
 Explore 5 diseases affiliated with
SIGLEC8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SIGLEC8    

Aliases
for SIGLEC8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sialic Acid Binding Ig-Like Lectin 81 2     SAF-22 3
SAF21 2 3 5     MGC597851
SIGLEC8L1 2 5     CDw3292
SIGLEC-81 2     Sialic Acid-Binding Ig-Like Lectin 82
Sialoadhesin Family Member 22 3     Siglec-83

External Ids:    HGNC: 108771   Entrez Gene: 271812   Ensembl: ENSG000001053667   OMIM: 6056395   UniProtKB: Q9NYZ43   

Export aliases for SIGLEC8 gene to outside databases

Previous GC identifers: GC19M052585 GC19M052315 GC19M056630 GC19M056646 GC19M051955 GC19M048286


Summaries
for SIGLEC8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SIGLEC8:
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1
transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of
the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic
tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif
homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an
association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed
11095983)).(supplied by OMIM, May 2010)

UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be
masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC8


Genomic Views
for SIGLEC8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGLEC8 gene promoter:
         Max1   AML1a   AP-1   RelA   NF-kappaB   PPAR-gamma1   ARP-1   PPAR-gamma2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIGLEC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIGLEC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33-q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33-q13.41

SIGLEC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051956:  view genomic region     (about GC identifiers)

Start:
 51,954,101 bp from pter      End:
 51,961,708 bp from pter
Size:
 7,608 bases      Orientation:
 minus strand

Proteins
for SIGLEC8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 8 precursor  
Size: 499 amino acids; 54042 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q7Z728
Alternative splicing: 3 isoforms:  Q9NYZ4-1   Q9NYZ4-2   Q9NYZ4-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SIGLEC8: NX_Q9NYZ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYZ4

    • SIGLEC8 Protein expression data from MOPED and PaxDb:    About this image 
    SIGLEC8 Protein Expression
    REFSEQ proteins: NP_055257.2  
    ENSEMBL proteins: 
     ENSP00000389142   ENSP00000321077   ENSP00000339448  

    Human Recombinant Protein Products for SIGLEC8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: SIGLEC8
    OriGene Custom Protein Services for SIGLEC8 
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    Novus Biologicals SIGLEC8 Proteins
    Novus Biologicals SIGLEC8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SIGLEC8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SIGLEC8 for ontologies           About GeneDecksing



    SIGLEC8 Antibody Products: 
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    Assay Products for SIGLEC8: 
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    Uscn ELISAs and CLIAs for SIGLEC8

    Protein Domains /
    Families
    for SIGLEC8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SIGLEC8 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9NYZ4

    ProtoNet protein and cluster: Q9NYZ4

    3 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif
    (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2
    domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for SIGLEC8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL8_HUMAN, Q9NYZ4
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be
    masked by cis interactions with sialic acids on the same cell surface

         Genatlas biochemistry entry for SIGLEC8:
    sialic acid binding Ig-like lectin 8,specifically expressed by eosinophils,sialoadhesin family,Ig superfamily

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10625619
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding TAS10625619
         
    SIGLEC8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC8:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Siglece (no phenotypes)

    SIGLEC8 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Siglecetm1Lex for SIGLEC8
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SIGLEC8 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SIGLEC8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SIGLEC8
    SwitchGear 3'UTR luciferase reporter plasmid: SIGLEC8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC8 (see all 4)
    OriGene shRNA RFP: SIGLEC8
    OriGene siRNA: SIGLEC8
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SIGLEC8 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SIGLEC8
    Sirion Biotech Customized adenovirus for overexpression of SIGLEC8 
    Sirion Biotech Customized adenovirus for potent knockdown of SIGLEC8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC8 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIGLEC8 (NM_014442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SIGLEC8
    Search LifeMap BioReagents cell lines for SIGLEC8
    Sirion Biotech Customized stable knockdown cell line services for SIGLEC8 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC8


    Pathways & Interactions
    for SIGLEC8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SIGLEC8 (Q9NYZ41 ENSP000003210774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFF1P041551, ENSP000002915274EBI-4314991,EBI-743871 STRING: ENSP00000291527
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS10625619

    SIGLEC8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SIGLEC8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIGLEC8
    Search CenterWatch for drugs/clinical trials and news about SIGLEC8 / SIGL8 

    Transcripts
    for SIGLEC8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SIGLEC8 gene: 
    NM_014442.2  

    Unigene Cluster for SIGLEC8:

    Sialic acid binding Ig-like lectin 8
    Hs.447899  [show with all ESTs]
    Unigene Representative Sequence: NM_014442
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430817(uc010yda.2) ENST00000321424(uc002pwt.3 uc002pwu.3)
    ENST00000340550(uc010eox.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SIGLEC8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SIGLEC8
    SwitchGear 3'UTR luciferase reporter plasmid: SIGLEC8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC8 (see all 4)
    OriGene shRNA RFP: SIGLEC8
    OriGene siRNA: SIGLEC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC8
    Sirion Biotech Custom design and validation of potent shRNA sequences against SIGLEC8 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC8 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIGLEC8 (NM_014442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC8

    Additional cDNA sequence: 

    AF195092.1 AF223403.1 AF310234.1 AK290149.1 AK290412.1 AK295589.1 BC053319.1 

    2 DOTS entries:

    DT.97773331  DT.92052184 

    11 AceView cDNA sequences:

    AF310234 AI057146 AA683022 BQ883649 BX281348 NM_014442 AF223403 AF195092 
    CD693435 CA434665 BX486282 

    GeneLoc Exon Structure


    Expression
    for SIGLEC8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIGLEC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGTGGTTC
    SIGLEC8 Expression
    About this image
    See SIGLEC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIGLEC8

    SOURCE GeneReport for Unigene cluster: Hs.447899

    UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
    Tissue specificity: Expressed specifically on eosinophils

        SABiosciences Expression via Pathway-Focused PCR Array including SIGLEC8: 
              Allergy & Asthma in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC8

    Orthologs
    for SIGLEC8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SIGLEC8 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 32(a)
    30(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343281.1(1713612-1717084)
    GL343281.1(1573835-1580218)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR548631.16
    si:ch211-171h4.56
    (see all 9)    		 si:ch211-171h4.5
    (see all 9)    		 21(a)
    19(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 4(948645-951913)
    19(11076841-11101335)


    ENSEMBL Gene Tree for SIGLEC8 (if available)
    TreeFam Gene Tree for SIGLEC8 (if available) 

    Paralogs
    for SIGLEC8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIGLEC8 gene
    CD332  SIGLEC17P2  SIGLEC52  SIGLEC162  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  
    MAG2  SIGLEC102  SIGLEC72  SIGLEC92  
    10 SIMAP similar genes for SIGLEC8 using alignment to 3 protein entries:     SIGL8_HUMAN (see all proteins):
    SIGLEC12    SIGLEC7    SIGLEC9    CEA    SIGLEC6    SIGLEC14
    CD33    SIGLEC10    SIGLEC5    SIGLEC16

    SIGLEC8 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SIGLEC8
    PGOHUM00000234380 PGOHUM00000234739 PGOHUM00000250612


    Genomic Variants
    for SIGLEC8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 NCBI SNPs in SIGLEC8 are shown (see all 217)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1387006311,2
    		Cother51958737(+) GAGCTC/TGGCAG 2 Q R mis11Minor allele frequency- T:0.00NA 4546
    rs364881,2
    		C,F,A--51953785(+) GAATCG/ACTTGA 1 -- ds50016Minor allele frequency- A:0.50NA WA CSA 10
    rs1504986231,2
    		--51953792(+) TTGAAC/TTCGGG 1 -- ds50010--------
    rs1844220941,2
    		--51953948(+) GGTGAC/TGCCAA 1 -- ds50010--------
    rs364891,2
    		C,F,A,H--51954094(+) TTGAGA/GAGCTG 1 -- ds500122Minor allele frequency- G:0.27NS EA NA WA 2766
    rs1904604851,2
    		--51954155(+) AGCTGC/TGTGAT 1 -- ds50010--------
    rs1817941621,2
    		--51954221(+) TTTCAC/TACTGC 1 -- ds50010--------
    rs1837081,2
    		C,F,A--51954278(+) TAATTA/GACTCA 1 -- ut31 ese38Minor allele frequency- G:0.38NA WA CSA 13
    rs113530491,2
    		C--51954583(+) GCAAT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs364901,2
    		C--51954592(+) AAAAAT/CGTTTT 1 -- ut313Minor allele frequency- C:0.25MN NA CSA 187

    HapMap Linkage Disequilibrium report for SIGLEC8 (51954101 - 51961708 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SIGLEC8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC8
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC8

    Disorders / Diseases
    for SIGLEC8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SIGLEC8 for disorders           About GeneDecksing

    OMIM gene information: 605639    OMIM disorders: --

    5 diseases for SIGLEC8:    About MalaCards
    eosinophilic esophagitis    hepatitis b    esophagitis    asthma
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SIGLEC8:
    Eosinophilic esophagitis
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC8 (2 documents)

    Export disorders for SIGLEC8 gene to outside databases

    Publications
    for SIGLEC8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIGLEC8 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SIGLEC8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. (PubMed id 10625619)1, 2, 3 Floyd H....Crocker P.R. (2000)
    2. Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene. (PubMed id 11095983)1, 2, 9 Foussias G.... Diamandis E.P. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. (PubMed id 10856141)1, 2 Kikly K.K.... White J.R. (2000)
    5. Polymorphisms in the sialic acid-binding immunoglobul in-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. (PubMed id 20087405)1, 9 Gao P.S....Bochner B.S. (2010)
    6. Biomarkers of eosinophil involvement in allergic and e osinophilic diseases: review of phenotypic and serum markers including a novel a ssay to quantify levels of soluble Siglec-8. (PubMed id 22683541)1 Na H.J....Bochner B.S. (2012)
    7. Siglec-8 and Siglec-F, the new therapeutic targets in asthma. (PubMed id 22324980)1 Farid S.S.h....Razavi A. (2012)
    8. IL-33 enhances Siglec-8 mediated apoptosis of human eo sinophils. (PubMed id 22079334)1 Na H.J....Bochner B.S. (2012)
    9. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    10. Developmental, malignancy-related, and cross-species a nalysis of eosinophil, mast cell, and basophil siglec-8 expression. (PubMed id 21938510)1 Hudson S.A....Bochner B.S. (2011)

    External Searches for SIGLEC8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SIGLEC8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27181 HGNC: 10877 AceView: SIGLEC8 Ensembl:ENSG00000105366 euGenes: HUgn27181
    ECgene: SIGLEC8 H-InvDB: SIGLEC8

    Other Databases showing SIGLEC8 gene

    (According to HUGE)
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    		   --

    Specialized Databases showing SIGLEC8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIGLEC8 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00146

    Intellectual Property
    for SIGLEC8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for SIGLEC8 gene:
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