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SIGLEC8 Gene

protein-coding   GIFtS: 55
GCID: GC19M051956

Sialic Acid Binding Ig-Like Lectin 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 81 2     CDw3292
SAF22 3 5     SIGLEC-82
Sialoadhesin Family Member 22 3     Sialic Acid-Binding Ig-Like Lectin 82
SAF-22 3     Siglec-83
SIGLEC8L2 5     

External Ids:    HGNC: 108771   Entrez Gene: 271812   Ensembl: ENSG000001053667   OMIM: 6056395   UniProtKB: Q9NYZ43   

Export aliases for SIGLEC8 gene to outside databases

Previous GC identifers: GC19M052585 GC19M052315 GC19M056630 GC19M056646 GC19M051955 GC19M048286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIGLEC8 Gene:
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1
transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member
of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic
tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif
homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an
association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed
11095983)).(supplied by OMIM, May 2010)

GeneCards Summary for SIGLEC8 Gene:
SIGLEC8 (sialic acid binding Ig-like lectin 8) is a protein-coding gene. Diseases associated with SIGLEC8 include eosinophilic esophagitis, and hepatitis b. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be
masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC8 gene promoter:
         Max1   AML1a   AP-1   RelA   NF-kappaB   PPAR-gamma1   ARP-1   PPAR-gamma2   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC8 promoter sequence
   Search Chromatin IP Primers for SIGLEC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33-q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33-q13.41

SIGLEC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051956:  view genomic region     (about GC identifiers)

Start:
51,954,101 bp from pter      End:
51,961,710 bp from pter
Size:
7,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 8 precursor  
Size: 499 amino acids; 54042 Da
Secondary accessions: Q7Z728
Alternative splicing: 3 isoforms:  Q9NYZ4-1   Q9NYZ4-2   Q9NYZ4-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SIGLEC8: NX_Q9NYZ4

Explore proteomics data for SIGLEC8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn172, Asn249, Asn267
  • Modification sites at PhosphoSitePlus

  • See SIGLEC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055257.2  
    ENSEMBL proteins: 
     ENSP00000389142   ENSP00000321077   ENSP00000339448  

    SIGLEC8 Human Recombinant Protein Products:

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    Novus Biologicals SIGLEC8 Proteins
    Novus Biologicals SIGLEC8 Lysate
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    Cloud-Clone Corp. Proteins for SIGLEC8

    SIGLEC8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIGLEC8
    R&D Systems Antibodies for SIGLEC8 (Siglec-8)
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    Novus Biologicals SIGLEC8 Antibodies
    Abcam antibodies for SIGLEC8
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    LSBio Antibodies in human, mouse, rat for SIGLEC8

    SIGLEC8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SIGLEC8
    Cloud-Clone Corp. CLIAs for SIGLEC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NYZ4

    ProtoNet protein and cluster: Q9NYZ4

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIGLEC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL8_HUMAN, Q9NYZ4
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be
    masked by cis interactions with sialic acids on the same cell surface

         Genatlas biochemistry entry for SIGLEC8:
    sialic acid binding Ig-like lectin 8,specifically expressed by eosinophils,sialoadhesin family,Ig superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS10625619
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding TAS10625619
         
    SIGLEC8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC8:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Siglece):
     hematopoietic system  immune system 

    SIGLEC8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Siglecetm1Croc for SIGLEC8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIGLEC8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIGLEC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIGLEC8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIGLEC8

    miRNA
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    miRTarBase miRNAs that target SIGLEC8:
    hsa-mir-335-5p (MIRT017964)

    Block miRNA regulation of human, mouse, rat SIGLEC8 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC8 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC8

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    GenScript: all cDNA clones in your preferred vector: SIGLEC8 (NM_014442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIGL8_HUMAN, Q9NYZ4: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    SIGLEC8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SIGLEC8: 
              Allergy & Asthma in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SIGLEC8 (Q9NYZ41 ENSP000003210774) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TFF1P041551, ENSP000002915274EBI-4314991,EBI-743871 STRING: ENSP00000291527
    SIRPAENSP000003483074STRING: ENSP00000348307
    IGSF11ENSP000003773704STRING: ENSP00000377370
    TAPBPLENSP000002665564STRING: ENSP00000266556
    LYZENSP000002612674STRING: ENSP00000261267
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS10625619

    SIGLEC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC8 (SIGL8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIGLEC8 gene: 
    NM_014442.2  

    Unigene Cluster for SIGLEC8:

    Sialic acid binding Ig-like lectin 8
    Hs.447899  [show with all ESTs]
    Unigene Representative Sequence: NM_014442
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430817(uc010yda.2) ENST00000321424(uc002pwt.3 uc002pwu.3)
    ENST00000340550(uc010eox.2) ENST00000597352
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SIGLEC8 (NM_014442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC8
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      QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC8
      QuantiFast Probe-based Assays in human, mouse, rat SIGLEC8

    Additional mRNA sequence: 

    AF195092.1 AF223403.1 AF310234.1 AK290149.1 AK290412.1 AK295589.1 BC053319.1 

    2 DOTS entries:

    DT.97773331  DT.92052184 

    11 AceView cDNA sequences:

    AA683022 AF310234 AI057146 BX281348 BQ883649 AF223403 NM_014442 AF195092 
    CD693435 CA434665 BX486282 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTGGTTC
    SIGLEC8 Expression
    About this image

    SIGLEC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447899

    UniProtKB/Swiss-Prot: SIGL8_HUMAN, Q9NYZ4
    Tissue specificity: Expressed specifically on eosinophils

        Pathway & Disease-focused RT2 Profiler PCR Array including SIGLEC8: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIGLEC8 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglece5
    Siglec51
    sialic acid binding Ig-like lectin E5
    sialic acid binding Ig-like lectin 51
    65.05(n)1
    53.87(a)1
      7 (28.25 cM)5
    2331861  NM_145581.21  NP_663556.11 
     436510705 


    ENSEMBL Gene Tree for SIGLEC8 (if available)
    TreeFam Gene Tree for SIGLEC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC8 gene
    CD332  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    9 SIMAP similar genes for SIGLEC8 using alignment to 2 protein entries:     SIGL8_HUMAN (see all proteins):
    SIGLEC9    SIGLEC12    SIGLEC7    CEA    SIGLEC6    SIGLEC14
    CD33    SIGLEC10    SIGLEC5

    SIGLEC8 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SIGLEC8
    PGOHUM00000234380 PGOHUM00000234739 PGOHUM00000250612


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC8 (see all 300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387006311,2
    Cuntested151958737(+) GAGCTC/TGGCAG 2 Q R mis11Minor allele frequency- T:0.00NA 4546
    rs364881,2
    C,F,A--51953785(+) gaatcG/Acttga 1 -- ds50016Minor allele frequency- A:0.50NA WA CSA 10
    rs1504986231,2
    C--51953792(+) TTGAAC/TTCGGG 1 -- ds50010--------
    rs1844220941,2
    --51953948(+) GGTGAC/TGCCAA 1 -- ds50010--------
    rs364891,2
    C,F,A,H--51954094(+) ttgagA/Gagctg 1 -- ds500122Minor allele frequency- G:0.27NS EA NA WA 2766
    rs1904604851,2
    --51954155(+) AGCTGC/TGTGAT 1 -- ds50010--------
    rs1817941621,2
    --51954221(+) TTTCAC/TACTGC 1 -- ds50010--------
    rs1837081,2
    C,F,A--51954278(+) taattA/Gactca 1 -- ut31 ese38Minor allele frequency- G:0.38NA WA CSA 13
    rs113530491,2
    C--51954583(+) GCAAT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs364901,2
    C,F--51954592(+) AAAAAT/CGTTTT 1 -- ut313Minor allele frequency- C:0.25MN NA CSA 187

    HapMap Linkage Disequilibrium report for SIGLEC8 (51954101 - 51961710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SIGLEC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458724CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC8
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605639    OMIM disorders: --

    5 diseases for SIGLEC8:    
    About MalaCards
    eosinophilic esophagitis    hepatitis b    asthma    esophagitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for SIGLEC8:
    Eosinophilic esophagitis

    SIGLEC8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIGLEC8
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC8 (2 documents)

    Export disorders for SIGLEC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC8 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SIGLEC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. (PubMed id 10625619)1, 2, 3 Floyd H....Crocker P.R. (J. Biol. Chem. 2000)
    2. Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene. (PubMed id 11095983)1, 2, 9 Foussias G.... Diamandis E.P. (Biochem. Biophys. Res. Commun. 2000)
    3. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. (PubMed id 20087405)1, 4, 9 Gao P.S....Bochner B.S. (Eur. J. Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. (PubMed id 10856141)1, 2 Kikly K.K.... White J.R. (J. Allergy Clin. Immunol. 2000)
    6. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. (PubMed id 23684072)1 Kano G....Zimmermann N. (J. Allergy Clin. Immunol. 2013)
    7. Siglec-8 in induced sputum of COPD patients. (PubMed id 23835953)1 Mroz R.M....Braszko J.J. (Adv. Exp. Med. Biol. 2013)
    8. A secreted protein microarray platform for extracellular protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (Anal. Biochem. 2012)
    9. Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8. (PubMed id 22683541)1 Na H.J....Bochner B.S. (J. Immunol. Methods 2012)
    10. Siglec-8 and Siglec-F, the new therapeutic targets in asthma. (PubMed id 22324980)1 Farid S.S.h....Razavi A. (Immunopharmacol Immunotoxicol 2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27181 HGNC: 10877 AceView: SIGLEC8 Ensembl:ENSG00000105366 euGenes: HUgn27181
    ECgene: SIGLEC8 H-InvDB: SIGLEC8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC8 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00146

    (Patent information from GeneIP,
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    Patent Information for SIGLEC8 gene:
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