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Aliases for SIGLEC8 Gene

Aliases for SIGLEC8 Gene

  • Sialic Acid Binding Ig Like Lectin 8 2 3
  • Sialic Acid Binding Ig-Like Lectin 8 2 3 5
  • Sialoadhesin Family Member 2 3 4
  • SIGLEC-8 3 4
  • SAF-2 3 4
  • SAF2 3 4
  • SIGLEC8L 3
  • CDw329 3

External Ids for SIGLEC8 Gene

Previous GeneCards Identifiers for SIGLEC8 Gene

  • GC19M052585
  • GC19M052315
  • GC19M056630
  • GC19M056646
  • GC19M051955
  • GC19M048286
  • GC19M051956

Summaries for SIGLEC8 Gene

Entrez Gene Summary for SIGLEC8 Gene

  • Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]

GeneCards Summary for SIGLEC8 Gene

SIGLEC8 (Sialic Acid Binding Ig Like Lectin 8) is a Protein Coding gene. Among its related pathways are Immune System and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot for SIGLEC8 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC8 Gene

Genomics for SIGLEC8 Gene

Regulatory Elements for SIGLEC8 Gene

Promoters for SIGLEC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIGLEC8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC8 Gene

Chromosome:
19
Start:
51,450,847 bp from pter
End:
51,458,456 bp from pter
Size:
7,610 bases
Orientation:
Minus strand

Genomic View for SIGLEC8 Gene

Genes around SIGLEC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC8 Gene

Proteins for SIGLEC8 Gene

  • Protein details for SIGLEC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYZ4-SIGL8_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 8
    Protein Accession:
    Q9NYZ4
    Secondary Accessions:
    • Q7Z728

    Protein attributes for SIGLEC8 Gene

    Size:
    499 amino acids
    Molecular mass:
    54042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC8 Gene

Proteomics data for SIGLEC8 Gene at MOPED

Post-translational modifications for SIGLEC8 Gene

  • Glycosylation at Asn 172, Asn 249, and Asn 267
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SIGLEC8 Gene

Domains & Families for SIGLEC8 Gene

Suggested Antigen Peptide Sequences for SIGLEC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYZ4

UniProtKB/Swiss-Prot:

SIGL8_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC8: view

Function for SIGLEC8 Gene

Molecular function for SIGLEC8 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 8,specifically expressed by eosinophils,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
genes like me logo Genes that share phenotypes with SIGLEC8: view

Animal Models for SIGLEC8 Gene

MGI Knock Outs for SIGLEC8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC8 Gene

Localization for SIGLEC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC8 Gene COMPARTMENTS Subcellular localization image for SIGLEC8 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SIGLEC8 Gene

Pathways & Interactions for SIGLEC8 Gene

genes like me logo Genes that share pathways with SIGLEC8: view

Gene Ontology (GO) - Biological Process for SIGLEC8 Gene

None

No data available for SIGNOR curated interactions for SIGLEC8 Gene

Drugs & Compounds for SIGLEC8 Gene

No Compound Related Data Available

Transcripts for SIGLEC8 Gene

mRNA/cDNA for SIGLEC8 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC8 Gene

Sialic acid binding Ig-like lectin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC8 Gene

No ASD Table

Relevant External Links for SIGLEC8 Gene

GeneLoc Exon Structure for
SIGLEC8
ECgene alternative splicing isoforms for
SIGLEC8

Expression for SIGLEC8 Gene

mRNA expression in normal human tissues for SIGLEC8 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC8 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.9), Spleen (x5.5), and Brain - Substantia nigra (x5.1).

Protein differential expression in normal tissues from HIPED for SIGLEC8 Gene

This gene is overexpressed in Heart (52.0) and Adipocyte (17.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC8 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC8 Gene Hs.447899

mRNA Expression by UniProt/SwissProt for SIGLEC8 Gene

Q9NYZ4-SIGL8_HUMAN
Tissue specificity: Expressed specifically on eosinophils.
genes like me logo Genes that share expression patterns with SIGLEC8: view

Protein tissue co-expression partners for SIGLEC8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC8 Gene

Orthologs for SIGLEC8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC8 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
OneToMany
LOC618463 35
  • 67.33 (n)
  • 54.42 (a)
dog
(Canis familiaris)
Mammalia SIGLEC12 35
  • 70.05 (n)
  • 59.7 (a)
-- 36
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Siglece 36
  • 54 (a)
OneToMany
Siglecf 16
Siglec5 35
  • 65.05 (n)
  • 53.87 (a)
rat
(Rattus norvegicus)
Mammalia Siglec5 35
  • 65.59 (n)
  • 52.58 (a)
Species with no ortholog for SIGLEC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC8 Gene

ENSEMBL:
Gene Tree for SIGLEC8 (if available)
TreeFam:
Gene Tree for SIGLEC8 (if available)

Paralogs for SIGLEC8 Gene

(9) SIMAP similar genes for SIGLEC8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SIGLEC8 Gene

genes like me logo Genes that share paralogs with SIGLEC8: view

Variants for SIGLEC8 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10409962 - 51,457,686(+) CCTGG(A/G)GTGGC intron-variant, reference, missense
rs3829659 - 51,454,302(-) CCTGC(A/G)GGAAG reference, missense
VAR_064751 -
rs36493 -- 51,455,198(+) CCGGG(C/T)CCCAG intron-variant
rs183708 -- 51,451,024(+) taatt(A/G)actca utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC8 Gene

Variant ID Type Subtype PubMed ID
nsv458724 CNV Gain 19166990

Variation tolerance for SIGLEC8 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.51; 88.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC8 Gene

HapMap Linkage Disequilibrium report
SIGLEC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC8 Gene

Disorders for SIGLEC8 Gene

Relevant External Links for SIGLEC8

Genetic Association Database (GAD)
SIGLEC8
Human Genome Epidemiology (HuGE) Navigator
SIGLEC8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC8

No disorders were found for SIGLEC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC8 Gene

Publications for SIGLEC8 Gene

  1. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. (PMID: 10625619) Floyd H. … Crocker P.R. (J. Biol. Chem. 2000) 2 3 4 67
  2. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. (PMID: 20087405) Gao P.S. … Bochner B.S. (Eur. J. Hum. Genet. 2010) 3 23
  3. Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene. (PMID: 11095983) Foussias G. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells. (PMID: 25747723) Jia Y. … Schnaar R.L. (J. Allergy Clin. Immunol. 2015) 3
  5. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. (PMID: 23684072) Kano G. … Zimmermann N. (J. Allergy Clin. Immunol. 2013) 3

Products for SIGLEC8 Gene

Sources for SIGLEC8 Gene

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