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Aliases for SIGLEC8 Gene

Aliases for SIGLEC8 Gene

  • Sialic Acid Binding Ig-Like Lectin 8 2 3
  • SAF2 3 4 6
  • Sialoadhesin Family Member 2 3 4
  • SIGLEC-8 3 4
  • SIGLEC8L 3 6
  • SAF-2 3 4
  • Sialic Acid-Binding Ig-Like Lectin 8 3
  • CDw329 3

External Ids for SIGLEC8 Gene

Summaries for SIGLEC8 Gene

Entrez Gene Summary for SIGLEC8 Gene

  • Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]

GeneCards Summary for SIGLEC8 Gene

SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC8 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC8 Gene

Genomics for SIGLEC8 Gene

Genomic Location for SIGLEC8 Gene

51,450,847 bp from pter
51,458,456 bp from pter
7,610 bases
Minus strand

Genomic View for SIGLEC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC8 Gene

Regulatory Elements for SIGLEC8 Gene

Proteins for SIGLEC8 Gene

  • Protein details for SIGLEC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 8
    Protein Accession:
    Secondary Accessions:
    • Q7Z728

    Protein attributes for SIGLEC8 Gene

    499 amino acids
    Molecular mass:
    54042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC8 Gene


neXtProt entry for SIGLEC8 Gene

Proteomics data for SIGLEC8 Gene at MOPED

Post-translational modifications for SIGLEC8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn172, Asn249, and Asn267

Other Protein References for SIGLEC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC8 Gene

Domains for SIGLEC8 Gene

Gene Families for SIGLEC8 Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins


  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q9NYZ4
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q9NYZ4
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9NYZ4
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • Q9NYZ4
genes like me logo Genes that share domains with SIGLEC8: view

Function for SIGLEC8 Gene

Molecular function for SIGLEC8 Gene

GENATLAS Biochemistry: sialic acid binding Ig-like lectin 8,specifically expressed by eosinophils,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Ontology (GO) - Molecular Function for SIGLEC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 10625619
GO:0005515 protein binding IPI 21982860
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC8: view

Phenotypes for SIGLEC8 Gene

MGI mutant phenotypes for SIGLEC8:
inferred from 2 alleles
GenomeRNAi human phenotypes for SIGLEC8:
genes like me logo Genes that share phenotypes with SIGLEC8: view

Animal Models for SIGLEC8 Gene

MGI Knock Outs for SIGLEC8:

miRNA for SIGLEC8 Gene

miRTarBase miRNAs that target SIGLEC8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIGLEC8 Gene

Localization for SIGLEC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SIGLEC8 Gene COMPARTMENTS Subcellular localization image for SIGLEC8 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SIGLEC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC8: view

Pathways for SIGLEC8 Gene

SuperPathways for SIGLEC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 10625619
genes like me logo Genes that share ontologies with SIGLEC8: view

No data available for Pathways by source for SIGLEC8 Gene

Transcripts for SIGLEC8 Gene

mRNA/cDNA for SIGLEC8 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC8 Gene

Sialic acid binding Ig-like lectin 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC8 Gene

No ASD Table

Relevant External Links for SIGLEC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLEC8 Gene

mRNA expression in normal human tissues for SIGLEC8 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC8 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.9), Spleen (5.5), and Brain - Substantia nigra (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC8 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC8 Gene Hs.447899

mRNA Expression by UniProt/SwissProt for SIGLEC8 Gene

Tissue specificity: Expressed specifically on eosinophils
genes like me logo Genes that share expressions with SIGLEC8: view

Orthologs for SIGLEC8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIGLEC8 37
  • 98 (a)
(Bos Taurus)
Mammalia -- 37
  • 70 (a)
LOC618463 36
  • 67.33 (n)
  • 54.42 (a)
(Canis familiaris)
Mammalia -- 37
  • 53 (a)
  • 70.05 (n)
  • 59.7 (a)
(Mus musculus)
Mammalia Siglec5 36
  • 65.05 (n)
  • 53.87 (a)
Siglece 16
Siglece 37
  • 54 (a)
(Rattus norvegicus)
Mammalia Siglec5 36
  • 65.59 (n)
  • 52.58 (a)
Species with no ortholog for SIGLEC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC8 Gene

Gene Tree for SIGLEC8 (if available)
Gene Tree for SIGLEC8 (if available)

Paralogs for SIGLEC8 Gene

Selected SIMAP similar genes for SIGLEC8 Gene using alignment to 2 proteins: Pseudogenes for SIGLEC8 Gene

genes like me logo Genes that share paralogs with SIGLEC8: view

Variants for SIGLEC8 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs36488 -- 51,450,531(+) gaatc(A/G)cttga downstream-variant-500B
rs36489 -- 51,450,840(+) ttgag(A/G)agctg downstream-variant-500B
rs36490 -- 51,451,338(+) AAAAA(C/T)GTTTT utr-variant-3-prime, nc-transcript-variant
rs36491 -- 51,452,372(+) GTTCT(A/G)TGAGA utr-variant-3-prime, intron-variant
rs36492 -- 51,454,681(+) ATGCT(C/T)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC8 Gene

Variant ID Type Subtype PubMed ID
nsv458724 CNV Gain 19166990

Relevant External Links for SIGLEC8 Gene

HapMap Linkage Disequilibrium report

Disorders for SIGLEC8 Gene

(1) University of Copenhagen DISEASES for SIGLEC8 Gene

Relevant External Links for SIGLEC8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SIGLEC8: view

No data available for UniProtKB/Swiss-Prot for SIGLEC8 Gene

Publications for SIGLEC8 Gene

  1. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. (PMID: 20087405) Gao P.S. … Bochner B.S. (Eur. J. Hum. Genet. 2010) 3 23 49
  2. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. (PMID: 10625619) Floyd H. … Crocker P.R. (J. Biol. Chem. 2000) 2 3 4
  3. Molecular characterization of a siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the siglec8 gene. (PMID: 11095983) Foussias G. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. (PMID: 10856141) Kikly K.K. … White J.R. (J. Allergy Clin. Immunol. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SIGLEC8 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Allergy & Asthma in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SIGLEC8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SIGLEC8
    • Block miRNA regulation of SIGLEC8 using miScript Target Protectors

    Sources for SIGLEC8 Gene

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