SIGLEC7 Gene
protein-coding GIFtS: 56
GCID: GC19P051645
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|
sialic acid binding Ig-like lectin 7
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Aliases
for SIGLEC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sialic Acid Binding Ig-Like Lectin 71 2 | | P751 | | AIRM12 3 5 | | QA79 Membrane Protein2 3 | | CD3281 2 | | Adhesion Inhibitory Receptor Molecule 1, Siglec-72 | | QA791 2 | | Sialic Acid Binding Immunoglobulin-Like Lectin 72 | | SIGLEC-71 2 | | Sialic Acid-Binding Ig-Like Lectin 72 | | P75/AIRM11 | | Siglec-73 | | AIRM-12 3 | | Adhesion Inhibitory Receptor Molecule 13 | | CDw3282 3 | | CD328 Antigen3 | | D-Siglec1 | | |
Export aliases for SIGLEC7 gene to outside databasesPrevious GC identifers: GC19P052276 GC19P052006 GC19P056321 GC19P056337 GC19P056299 GC19P047978 |
Summaries
for SIGLEC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)
Gene Wiki entry for SIGLEC7
|
Genomic Views
for SIGLEC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIGLEC7 gene promoter:
CREB PPAR-gamma1 deltaCREB ARP-1 CUTL1 PPAR-gamma2 TGIF Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIGLEC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.3SIGLEC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P051645: view genomic region
(about GC identifiers)
Start:
|
51,645,558 bp from pter |
End:
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51,656,783 bp from pter |
Size:
|
11,226 bases |
Orientation:
|
plus strand |
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Proteins
for SIGLEC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286 (See
protein sequence)Recommended Name: Sialic acid-binding Ig-like lectin 7 precursor Size: 467 amino acids; 51143 Da
Subunit: Interacts with PTPN6/SHP-1 upon phosphorylation
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAF44346.1; Type=Frameshift; Positions=406;
6 PDB 3D structures from  and Proteopedia  for SIGLEC7:1NKO (3D)
1O7S (3D)
1O7V (3D)
2DF3 (3D)
2G5R (3D)
2HRL (3D)
Secondary accessions: Q9NZQ1 Q9UJ86 Q9UJ87 Q9Y502Alternative splicing: 4 isoforms: Q9Y286-1 Q9Y286-2 Q9Y286-3 Q9Y286-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIGLEC7: NX_Q9Y286
Post-translational modifications:
Tyrosine phosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y286
SIGLEC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055200.1 NP_057627.2
ENSEMBL proteins: ENSP00000323328 ENSP00000306757 ENSP00000437609
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SIGLEC7 for ontologies About GeneDecksing
SIGLEC7 Antibody Products:
Assay Products for SIGLEC7: |
Protein
Domains /
Families
for SIGLEC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIGLEC7 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y286ProtoNet protein and cluster: Q9Y286 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2domain of several SH2-containing phosphatasesSimilarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIGLEC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyllactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked bycis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptorupon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) thatblock signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killercells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towardsmyelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro) Genatlas biochemistry entry for SIGLEC7:sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells andmonocytes,sialoadhesin,Ig superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SIGLEC7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SIGLEC7:
|
Pathways & Interactions
for SIGLEC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIGLEC7
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for SIGLEC7 (Q9Y2863 ENSP000003233284) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
SIGLEC7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIGLEC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SIGLEC7 for compounds About GeneDecksing
 Browse Tocris compounds for SIGLEC7
3 DrugBank Compounds for SIGLEC7 About this table
1 Novoseek chemical compound relationship for SIGLEC7 gene About this table
Search CenterWatch for drugs/clinical trials and news about SIGLEC7 / SIGL7
|
Transcripts
for SIGLEC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIGLEC7 gene (2 alternative transcripts): NM_014385.2 NM_016543.2 Unigene Cluster for SIGLEC7: Sialic acid binding Ig-like lectin 7 Hs.655393 [show with all ESTs]Unigene Representative Sequence: BC0281503 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317643(uc002pvv.1) ENST00000305628(uc002pvw.1 uc010eoq.1 uc010eor.1)
ENST00000536156
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIGLEC7 (NM_016543) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC7 |
Additional cDNA sequence: AF170485.1 AF178981.1 AF193441.1 AJ007395.1 AJ130710.1 AJ130711.1 AJ130712.1 AJ130713.1 AK314875.1 BC028150.1 3 DOTS entries: DT.95366762 DT.75133610 DT.91987074 24/29 AceView cDNA sequences (see all 29): AJ130711 BC028150 AF170485 AA835515 AF193441 AJ130713 BE378325 AJ130710 BM662450 AF178981 AA344713 BI906299 AW469884 AW295848 AJ007395 BM921873 AJ130712 NM_016543 BX644517 BI908021 T48851 BI910068 NM_014385 AW571432
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIGLEC7
|
Expression
for SIGLEC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIGLEC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGATGACC
About this image
See SIGLEC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIGLEC7
SOURCE GeneReport for Unigene cluster: Hs.655393
UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels bygranulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for SIGLEC7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC7
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC7 |
Orthologs
for SIGLEC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIGLEC7 gene from 2/5 species (see all 5) About this table
ENSEMBL Gene Tree for SIGLEC7 (if available)
TreeFam Gene Tree for SIGLEC7 (if available) |
Paralogs
for SIGLEC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIGLEC7 gene
- CD332 SIGLEC17P2 SIGLEC82 SIGLEC52 SIGLEC162 SIGLEC112 SIGLEC62 SIGLEC142
- SIGLEC122 MAG2 SIGLEC102 SIGLEC92
10 SIMAP similar genes for SIGLEC7 using alignment to 2 protein entries: SIGL7_HUMAN (see all proteins):SIGLEC12 SIGLEC9 SIGLEC8 SIGLEC6 SIGLEC11 SIGLEC14
SIGLEC10 SIGLEC16 CD33 SIGLEC5
SIGLEC7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIGLEC7
PGOHUM00000234378
|
Genomic Variants
for SIGLEC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIGLEC7 (51645558 - 51656783 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIGLEC7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC7 |
|
Disorders
/ Diseases
for SIGLEC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIGLEC7 for disorders About GeneDecksing
OMIM gene information: 604410
OMIM disorders: --
20/21  diseases for SIGLEC7 (see all 21): About MalaCardslarge granular lymphocyte leukemia non-hodgkin lymphoma granular cell tumor hodgkin's lymphoma
acute myeloid leukemia lymphocytic leukemia myeloid leukemia renal cell carcinoma
pheochromocytoma hepatitis b leukemia liver disease
colon cancer periodontitis ovarian cancer hepatitis
cholesterol carcinoma neuronitis hiv-1 viremia
1 disease from the University of Copenhagen DISEASES database for SIGLEC7:Miller Fisher syndrome 3 Novoseek disease relationships for SIGLEC7 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SIGLEC7 (1 document)
Export disorders for SIGLEC7 gene to outside databases
|
Publications
for SIGLEC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIGLEC7 gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with SIGLEC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PubMed id 10567377)1, 2, 3, 9 Nicoll G.... Crocker P.R. (1999)
- The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. (PubMed id 16623661)1, 2 Attrill H....van Aalten D.M. (2006)
- Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. (PubMed id 14747738)1, 2 Dimasi N....Mariuzza R.A. (2004)
- High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. (PubMed id 12438315)1, 2 Alphey M.S....van Aalten D.M. (2003)
- Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. (PubMed id 11389909)1, 2 Ito A.... Hakomori S. (2001)
- Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. (PubMed id 10764831)1, 2 Angata T. and Varki A. (2000)
- Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. (PubMed id 10611343)1, 2 Vitale C.... Mingari M.C. (1999)
- Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. (PubMed id 10499918)1, 2 Falco M.... Moretta A. (1999)
- SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. (PubMed id 8188688)1, 9 Reif K....Cantrell D.A. (1994)
- The decreased expression of Siglec-7 represents an ea rly marker of dysfunctional natural killer-cell subsets associated with high le vels of HIV-1 viremia. (PubMed id 19710502)1, 9 Brunetta E....Mavilio D. (2009)
|
External Searches for SIGLEC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIGLEC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIGLEC7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIGLEC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIGLEC7 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_274 |
|
| | |
About This Section
| Patent Information for SIGLEC7 gene:
Search GeneIP for patents involving SIGLEC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIGLEC7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC7 | | | OriGene Protein Over-expression Lysate for SIGLEC7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIGLEC7 | | OriGene 3'-UTR Clone for SIGLEC7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SIGLEC7 |
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 | | | SIGLEC7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC7 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC7 |
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