Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIGLEC7 Gene

Aliases for SIGLEC7 Gene

  • Sialic Acid Binding Ig Like Lectin 7 2 3
  • Sialic Acid Binding Ig-Like Lectin 7 2 3 5
  • QA79 Membrane Protein 3 4
  • SIGLEC-7 3 4
  • D-Siglec 3 4
  • AIRM-1 3 4
  • CDw328 3 4
  • AIRM1 3 4
  • P75 3 4
  • Sialic Acid Binding Ig-Like Lectin 19, Pseudogene 2
  • Adhesion Inhibitory Receptor Molecule 1, Siglec-7 3
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 2 2
  • Sialic Acid Binding Immunoglobulin-Like Lectin 7 3
  • Adhesion Inhibitory Receptor Molecule 1 4
  • CD328 Antigen 4
  • SIGLEC19P 3
  • P75/AIRM1 3
  • SIGLECP2 3
  • CD328 3
  • QA79 3

External Ids for SIGLEC7 Gene

Previous HGNC Symbols for SIGLEC7 Gene

  • SIGLEC19P
  • SIGLECP2

Previous GeneCards Identifiers for SIGLEC7 Gene

  • GC19P052276
  • GC19P052006
  • GC19P056321
  • GC19P056337
  • GC19P056299
  • GC19P051645
  • GC19P047978

Summaries for SIGLEC7 Gene

GeneCards Summary for SIGLEC7 Gene

SIGLEC7 (Sialic Acid Binding Ig Like Lectin 7) is a Protein Coding gene. Diseases associated with SIGLEC7 include pheochromocytoma. Among its related pathways are Immune System and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC10.

UniProtKB/Swiss-Prot for SIGLEC7 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Wiki entry for SIGLEC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC7 Gene

Genomics for SIGLEC7 Gene

Regulatory Elements for SIGLEC7 Gene

Promoters for SIGLEC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIGLEC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC7 Gene

Chromosome:
19
Start:
51,142,294 bp from pter
End:
51,153,526 bp from pter
Size:
11,233 bases
Orientation:
Plus strand

Genomic View for SIGLEC7 Gene

Genes around SIGLEC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC7 Gene

Proteins for SIGLEC7 Gene

  • Protein details for SIGLEC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y286-SIGL7_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 7
    Protein Accession:
    Q9Y286
    Secondary Accessions:
    • Q9NZQ1
    • Q9UJ86
    • Q9UJ87
    • Q9Y502

    Protein attributes for SIGLEC7 Gene

    Size:
    467 amino acids
    Molecular mass:
    51143 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAF44346.1; Type=Frameshift; Positions=406; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIGLEC7 Gene

    Alternative splice isoforms for SIGLEC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC7 Gene

Proteomics data for SIGLEC7 Gene at MOPED

Post-translational modifications for SIGLEC7 Gene

  • Tyrosine phosphorylated.
  • Glycosylation at Asn 105, Asn 142, Asn 165, Asn 229, Asn 235, Asn 242, Asn 260, and Asn 334
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC7 Gene

Antibody Products

  • R&D Systems Antibodies for SIGLEC7 (Siglec-7/CD328)

No data available for DME Specific Peptides for SIGLEC7 Gene

Domains & Families for SIGLEC7 Gene

Protein Domains for SIGLEC7 Gene

Suggested Antigen Peptide Sequences for SIGLEC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y286

UniProtKB/Swiss-Prot:

SIGL7_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC7: view

Function for SIGLEC7 Gene

Molecular function for SIGLEC7 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells and monocytes,sialoadhesin,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Ontology (GO) - Molecular Function for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10499918
genes like me logo Genes that share ontologies with SIGLEC7: view

Phenotypes for SIGLEC7 Gene

genes like me logo Genes that share phenotypes with SIGLEC7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLEC7 Gene

Localization for SIGLEC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC7 Gene COMPARTMENTS Subcellular localization image for SIGLEC7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SIGLEC7 Gene

Pathways & Interactions for SIGLEC7 Gene

genes like me logo Genes that share pathways with SIGLEC7: view

Gene Ontology (GO) - Biological Process for SIGLEC7 Gene

None

No data available for SIGNOR curated interactions for SIGLEC7 Gene

Drugs & Compounds for SIGLEC7 Gene

(2) Drugs for SIGLEC7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Experimental Pharma Target 0

(1) Additional Compounds for SIGLEC7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with SIGLEC7: view

Transcripts for SIGLEC7 Gene

Unigene Clusters for SIGLEC7 Gene

Sialic acid binding Ig-like lectin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5:

Relevant External Links for SIGLEC7 Gene

GeneLoc Exon Structure for
SIGLEC7
ECgene alternative splicing isoforms for
SIGLEC7

Expression for SIGLEC7 Gene

mRNA expression in normal human tissues for SIGLEC7 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC7 Gene

This gene is overexpressed in Whole Blood (x22.0) and Spleen (x9.2).

Protein differential expression in normal tissues from HIPED for SIGLEC7 Gene

This gene is overexpressed in NK cells (24.8), Monocytes (23.9), CD8 Tcells (6.5), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC7 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC7 Gene Hs.655393

mRNA Expression by UniProt/SwissProt for SIGLEC7 Gene

Q9Y286-SIGL7_HUMAN
Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SIGLEC7: view

Protein tissue co-expression partners for SIGLEC7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC7 Gene

Orthologs for SIGLEC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC7 35
  • 98.69 (n)
  • 97.37 (a)
-- 36
  • 45 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglece 36
  • 53 (a)
OneToMany
Species with no ortholog for SIGLEC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC7 Gene

ENSEMBL:
Gene Tree for SIGLEC7 (if available)
TreeFam:
Gene Tree for SIGLEC7 (if available)

Paralogs for SIGLEC7 Gene

(9) SIMAP similar genes for SIGLEC7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SIGLEC7 Gene

genes like me logo Genes that share paralogs with SIGLEC7: view

Variants for SIGLEC7 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035523 A colorectal cancer sample
rs273676 -- 51,143,779(+) GCAAA(C/T)GAAGA intron-variant
rs182126 -- 51,149,410(+) cagga(G/T)tcctt intron-variant
rs182127 -- 51,150,352(+) taaca(C/T)gaagc intron-variant
rs1846934 -- 51,145,440(-) TCACT(A/G)CTGAC intron-variant

Variation tolerance for SIGLEC7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC7 Gene

HapMap Linkage Disequilibrium report
SIGLEC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SIGLEC7 Gene

Disorders for SIGLEC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC7 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIGLEC7

Human Genome Epidemiology (HuGE) Navigator
SIGLEC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC7
genes like me logo Genes that share disorders with SIGLEC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC7 Gene

Publications for SIGLEC7 Gene

  1. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PMID: 10567377) Nicoll G. … Crocker P.R. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (PMID: 19710502) Brunetta E. … Mavilio D. (Blood 2009) 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. (PMID: 8188688) Reif K. … Cantrell D.A. (J. Biol. Chem. 1994) 3 23

Products for SIGLEC7 Gene

Sources for SIGLEC7 Gene

Back to Top

Content