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SIGLEC7 Gene

protein-coding   GIFtS: 55
GCID: GC19P051645

Sialic Acid Binding Ig-Like Lectin 7

(Previous names: sialic acid binding Ig-like lectin 19, pseudogene, sialic...)
(Previous symbols: SIGLEC19P, SIGLECP2)
  See SIGLEC7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 71 2     CD3282
AIRM12 3 5     QA792
SIGLEC19P1 2     SIGLEC-72
SIGLECP21 2     Adhesion Inhibitory Receptor Molecule 1, Siglec-72
AIRM-12 3     p75/AIRM12
CDw3282 3     Sialic Acid Binding Immunoglobulin-Like Lectin 72
D-siglec2 3     Sialic Acid-Binding Ig-Like Lectin 72
p752 3     Siglec-73
QA79 Membrane Protein2 3     Adhesion Inhibitory Receptor Molecule 13
Sialic Acid Binding Ig-Like Lectin 19, Pseudogene1     CD328 Antigen3
Sialic Acid Binding Ig-Like Lectin, Pseudogene 21     

External Ids:    HGNC: 108761   Entrez Gene: 270362   Ensembl: ENSG000001689957   OMIM: 6044105   UniProtKB: Q9Y2863   

Export aliases for SIGLEC7 gene to outside databases

Previous GC identifers: GC19P052276 GC19P052006 GC19P056321 GC19P056337 GC19P056299 GC19P047978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC7 Gene:
SIGLEC7 (sialic acid binding Ig-like lectin 7) is a protein-coding gene. Diseases associated with SIGLEC7 include miller fisher syndrome, and hiv-1 viremia. GO annotations related to this gene include carbohydrate binding and receptor activity. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside,
disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site
may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as
an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via
their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates
inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of
CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

Gene Wiki entry for SIGLEC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC7 gene promoter:
         CREB   PPAR-gamma1   deltaCREB   ARP-1   CUTL1   PPAR-gamma2   TGIF   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC7 promoter sequence
   Search Chromatin IP Primers for SIGLEC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051645:  view genomic region     (about GC identifiers)

Start:
51,645,556 bp from pter      End:
51,656,783 bp from pter
Size:
11,228 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 7 precursor  
Size: 467 amino acids; 51143 Da
Subunit: Interacts with PTPN6/SHP-1 upon phosphorylation
Sequence caution: Sequence=AAF44346.1; Type=Frameshift; Positions=406;
6 PDB 3D structures from and Proteopedia for SIGLEC7:
1NKO (3D)        1O7S (3D)        1O7V (3D)        2DF3 (3D)        2G5R (3D)        2HRL (3D)    
Secondary accessions: Q9NZQ1 Q9UJ86 Q9UJ87 Q9Y502
Alternative splicing: 4 isoforms:  Q9Y286-1   Q9Y286-2   Q9Y286-3   Q9Y286-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIGLEC7: NX_Q9Y286

Explore proteomics data for SIGLEC7 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated1
  • Glycosylation2 at Asn105, Asn142, Asn165, Asn229, Asn235, Asn242, Asn260, Asn334
  • Modification sites at PhosphoSitePlus

  • See SIGLEC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001264130.1  NP_055200.1  NP_057627.2  

    ENSEMBL proteins: 
     ENSP00000469626   ENSP00000323328   ENSP00000306757   ENSP00000437609   ENSP00000472529  

    SIGLEC7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SIGLEC7 Proteins
    Novus Biologicals SIGLEC7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIGLEC7

     
    Search eBioscience for Proteins for SIGLEC7 

    SIGLEC7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9Y286

    ProtoNet protein and cluster: Q9Y286

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIGLEC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL7_HUMAN, Q9Y286
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside,
    disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site
    may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as
    an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via
    their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates
    inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of
    CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro)

         Genatlas biochemistry entry for SIGLEC7:
    sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells and
    monocytes,sialoadhesin,Ig superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10499918
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding TAS10567377
         
    Find genes that share ontologies with SIGLEC7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC7:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIGLEC7
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIGL7_HUMAN, Q9Y286: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10567377

    Find genes that share ontologies with SIGLEC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC7
    Interactions:

        GeneGlobe Interaction Network for SIGLEC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SIGLEC7 (Q9Y2863 ENSP000003233284) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    TRAF4Q9BUZ43, ENSP000002623954I2D: score=2 STRING: ENSP00000262395
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    PIK3C2AO004433I2D: score=1 
    PTPN6P293503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with SIGLEC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC7 (SIGL7)

    3 DrugBank Compounds for SIGLEC7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose-- --target--17139284 17016423
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423
    Beta-D-Mannose-- 7322-31-8target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for SIGLEC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 46 14 8188688 (3), 8007965 (2), 1347947 (1), 9368064 (1) (see all 5)



    Find genes that share compounds with SIGLEC7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC7 gene (3 alternative transcripts): 
    NM_001277201.1  NM_014385.3  NM_016543.3  

    Unigene Cluster for SIGLEC7:

    Sialic acid binding Ig-like lectin 7
    Hs.655393  [show with all ESTs]
    Unigene Representative Sequence: BC028150
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601682 ENST00000317643(uc002pvv.1) ENST00000305628(uc002pvw.1 uc010eoq.1 uc010eor.1)
    ENST00000536156 ENST00000600577 ENST00000599250
    miRNA
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    Additional mRNA sequence: 

    AF170485.1 AF178981.1 AF193441.1 AJ007395.1 AJ130710.1 AJ130711.1 AJ130712.1 AJ130713.1 
    AK314875.1 BC028150.1 

    3 DOTS entries:

    DT.95366762  DT.75133610  DT.91987074 

    Selected AceView cDNA sequences (see all 29):

    AA835515 BC028150 AF170485 AF193441 AJ130713 AJ130711 BE378325 BM662450 
    BX644517 BM921873 AJ130712 BI908021 AJ007395 AW295848 AJ130710 T48851 
    NM_016543 AF178981 NM_014385 AA344713 BI906299 BI910068 AW469884 AW571432 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                                -                           
    SP2:        -                       -                           
    SP3:        -     -     -     -     -                           
    SP4:        -     -     -     -     -     -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for SIGLEC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGATGACC
    SIGLEC7 Expression
    About this image

    SIGLEC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655393

    UniProtKB/Swiss-Prot: SIGL7_HUMAN, Q9Y286
    Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by
    granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood
    leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for SIGLEC7 (if available)
    TreeFam Gene Tree for SIGLEC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC7 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC142  SIGLEC62  SIGLEC122  
    MAG2  SIGLEC102  SIGLEC92  
    9 SIMAP similar genes for SIGLEC7 using alignment to 2 protein entries:     SIGL7_HUMAN (see all proteins):
    SIGLEC12    SIGLEC9    SIGLEC8    SIGLEC6    SIGLEC11    SIGLEC14
    SIGLEC10    SIGLEC16    CD33

    Find genes that share paralogs with SIGLEC7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SIGLEC7
    PGOHUM00000234378


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC7 (see all 327)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355234
    A colorectal cancer sample4--see VAR_0355232 L P mis40--------
    rs713588141,2
    C,F--51643577(+) CCCGAA/TAAAAG 4 -- us2k12Minor allele frequency- T:0.06NA 122
    rs1490247451,2
    --51643617(+) TGGGAA/TGCGAA 4 -- us2k10--------
    rs24550671,2
    C,F,H--51643619(+) GGAAGC/TGAAGA 4 -- us2k14Minor allele frequency- T:0.01NS EA 420
    rs1391919581,2
    C--51643630(+) AAAAC-/AAAA  
            
    AAACA
    4 -- us2k10--------
    rs795129391,2
    C--51643633(+) ACAAAC/AAAACA 4 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs357309641,2
    C--51643750(+) CTTGC-/TTTTGC 4 -- us2k10--------
    rs1512100181,2
    --51643826(+) TCCGGC/TAACAC 4 -- us2k10--------
    rs1403671711,2
    --51643864(+) CCTTAC/TGGGGA 4 -- us2k10--------
    rs788913051,2
    F--51643958(+) GGTGAG/AGGCGG 4 -- us2k11Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for SIGLEC7 (51645556 - 51656783 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIGLEC7: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC7
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604410    OMIM disorders: --

    4 diseases for SIGLEC7:    
    About MalaCards
    miller fisher syndrome    hiv-1 viremia    pheochromocytoma    hiv-1

    1 disease from the University of Copenhagen DISEASES database for SIGLEC7:
    Miller Fisher syndrome

    Find genes that share disorders with SIGLEC7           About GenesLikeMe

    3 Novoseek inferred disease relationships for SIGLEC7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 24.8 1 15967538 (1)
    necrosis 20.9 6 8697709 (2), 9625312 (1), 11435417 (1), 9649158 (1)
    tumors 0 3 9625312 (1), 11435417 (1), 17448195 (1)

    Human Genome Epidemiology (HuGE) Navigator: SIGLEC7 (1 document)

    Export disorders for SIGLEC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC7 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with SIGLEC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PubMed id 10567377)1, 2, 3, 9 Nicoll G.... Crocker P.R. (J. Biol. Chem. 1999)
    2. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. (PubMed id 16623661)1, 2 Attrill H.... van Aalten D.M. (Biochem. J. 2006)
    3. Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. (PubMed id 14747738)1, 2 Dimasi N.... Mariuzza R.A. (Acta Crystallogr. D 2004)
    4. High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. (PubMed id 12438315)1, 2 Alphey M.S.... van Aalten D.M. (J. Biol. Chem. 2003)
    5. Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. (PubMed id 11389909)1, 2 Ito A.... Hakomori S. (FEBS Lett. 2001)
    6. Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. (PubMed id 10764831)1, 2 Angata T. and Varki A. (Glycobiology 2000)
    7. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. (PubMed id 10611343)1, 2 Vitale C.... Mingari M.C. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    8. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. (PubMed id 10499918)1, 2 Falco M.... Moretta A. (J. Exp. Med. 1999)
    9. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. (PubMed id 8188688)1, 9 Reif K....Cantrell D.A. (J. Biol. Chem. 1994)
    10. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (PubMed id 19710502)1, 9 Brunetta E....Mavilio D. (Blood 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27036 HGNC: 10876 AceView: SIGLEC7 Ensembl:ENSG00000168995 euGenes: HUgn27036
    ECgene: SIGLEC7 H-InvDB: SIGLEC7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC7 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_274

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SIGLEC7 gene:
    Search GeneIP for patents involving SIGLEC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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