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Aliases for SIGLEC7 Gene

Aliases for SIGLEC7 Gene

  • Sialic Acid Binding Ig-Like Lectin 7 2 3
  • AIRM1 3 4 6
  • QA79 Membrane Protein 3 4
  • SIGLEC-7 3 4
  • D-Siglec 3 4
  • AIRM-1 3 4
  • CDw328 3 4
  • P75 3 4
  • Sialic Acid Binding Ig-Like Lectin 19, Pseudogene 2
  • Adhesion Inhibitory Receptor Molecule 1, Siglec-7 3
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 2 2
  • Sialic Acid Binding Immunoglobulin-Like Lectin 7 3
  • Adhesion Inhibitory Receptor Molecule 1 4
  • Sialic Acid-Binding Ig-Like Lectin 7 3
  • CD328 Antigen 4
  • P75/AIRM1 3
  • SIGLEC19P 3
  • SIGLECP2 3
  • CD328 3
  • QA79 3

External Ids for SIGLEC7 Gene

Previous Symbols for SIGLEC7 Gene

  • SIGLEC19P
  • SIGLECP2

Summaries for SIGLEC7 Gene

GeneCards Summary for SIGLEC7 Gene

SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7) is a Protein Coding gene. Diseases associated with SIGLEC7 include miller fisher syndrome and hiv-1. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC7 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Wiki entry for SIGLEC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC7 Gene

Genomics for SIGLEC7 Gene

Genomic Location for SIGLEC7 Gene

Start:
51,142,299 bp from pter
End:
51,153,526 bp from pter
Size:
11,228 bases
Orientation:
Plus strand

Genomic View for SIGLEC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC7 Gene

Regulatory Elements for SIGLEC7 Gene

Proteins for SIGLEC7 Gene

  • Protein details for SIGLEC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y286-SIGL7_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 7
    Protein Accession:
    Q9Y286
    Secondary Accessions:
    • Q9NZQ1
    • Q9UJ86
    • Q9UJ87
    • Q9Y502

    Protein attributes for SIGLEC7 Gene

    Size:
    467 amino acids
    Molecular mass:
    51143 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAF44346.1; Type=Frameshift; Positions=406; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIGLEC7 Gene

    Alternative splice isoforms for SIGLEC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC7 Gene

Proteomics data for SIGLEC7 Gene at MOPED

Post-translational modifications for SIGLEC7 Gene

  • Tyrosine phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn105, Asn142, Asn165, Asn229, Asn235, Asn242, Asn260, and Asn334

Other Protein References for SIGLEC7 Gene

No data available for DME Specific Peptides for SIGLEC7 Gene

Domains for SIGLEC7 Gene

Gene Families for SIGLEC7 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

Protein Domains for SIGLEC7 Gene

UniProtKB/Swiss-Prot:

SIGL7_HUMAN
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q9Y286
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q9Y286
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9Y286
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • Q9Y286
genes like me logo Genes that share domains with SIGLEC7: view

Function for SIGLEC7 Gene

Molecular function for SIGLEC7 Gene

GENATLAS Biochemistry: sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells and monocytes,sialoadhesin,Ig superfamily
UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Ontology (GO) - Molecular Function for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10499918
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC7: view

Phenotypes for SIGLEC7 Gene

genes like me logo Genes that share phenotypes with SIGLEC7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIGLEC7 Gene

Localization for SIGLEC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC7 Gene COMPARTMENTS Subcellular localization image for SIGLEC7 gene
Compartment Confidence
plasma membrane 4
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10567377
genes like me logo Genes that share ontologies with SIGLEC7: view

Pathways for SIGLEC7 Gene

SuperPathways for SIGLEC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC7: view

No data available for Pathways by source for SIGLEC7 Gene

Compounds for SIGLEC7 Gene

(3) Drugbank Compounds for SIGLEC7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
target
Alpha-D-Mannose
3458-28-4 target
Beta-D-Mannose
7322-31-8 target

(1) Novoseek inferred chemical compound relationships for SIGLEC7 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 46 8
genes like me logo Genes that share compounds with SIGLEC7: view

Transcripts for SIGLEC7 Gene

Unigene Clusters for SIGLEC7 Gene

Sialic acid binding Ig-like lectin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5:

Relevant External Links for SIGLEC7 Gene

GeneLoc Exon Structure for
SIGLEC7
ECgene alternative splicing isoforms for
SIGLEC7

Expression for SIGLEC7 Gene

mRNA expression in normal human tissues for SIGLEC7 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC7 Gene

This gene is overexpressed in Whole Blood (22.0) and Spleen (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC7 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC7 Gene Hs.655393

mRNA Expression by UniProt/SwissProt for SIGLEC7 Gene

Q9Y286-SIGL7_HUMAN
Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes
genes like me logo Genes that share expressions with SIGLEC7: view

Orthologs for SIGLEC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 45 (a)
ManyToMany
SIGLEC7 36
  • 98.69 (n)
  • 97.37 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglece 37
  • 53 (a)
OneToMany
Species with no ortholog for SIGLEC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC7 Gene

ENSEMBL:
Gene Tree for SIGLEC7 (if available)
TreeFam:
Gene Tree for SIGLEC7 (if available)

Paralogs for SIGLEC7 Gene

Selected SIMAP similar genes for SIGLEC7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SIGLEC7 Gene

genes like me logo Genes that share paralogs with SIGLEC7: view

Variants for SIGLEC7 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs182126 -- 51,149,410(+) cagga(G/T)tcctt intron-variant
rs182127 -- 51,150,352(+) taaca(C/T)gaagc intron-variant
rs273676 -- 51,143,779(+) GCAAA(C/T)GAAGA intron-variant
rs273677 -- 51,144,262(+) GAAAG(C/G)CTGGG intron-variant
rs1628793 -- 51,141,665(+) AGGCG(C/G)AATCC upstream-variant-2KB

Relevant External Links for SIGLEC7 Gene

HapMap Linkage Disequilibrium report
SIGLEC7

No data available for Structural Variations from Database of Genomic Variants (DGV) for SIGLEC7 Gene

Disorders for SIGLEC7 Gene

(1) University of Copenhagen DISEASES for SIGLEC7 Gene

(3) Novoseek inferred disease relationships for SIGLEC7 Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 24.8 1
necrosis 20.9 5
tumors 0 3

Relevant External Links for SIGLEC7

Human Genome Epidemiology (HuGE) Navigator
SIGLEC7
genes like me logo Genes that share disorders with SIGLEC7: view

No data available for UniProtKB/Swiss-Prot for SIGLEC7 Gene

Publications for SIGLEC7 Gene

  1. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PMID: 10567377) Nicoll G. … Crocker P.R. (J. Biol. Chem. 1999) 2 3 4 23
  2. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. (PMID: 8188688) Reif K. … Cantrell D.A. (J. Biol. Chem. 1994) 3 23
  3. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (PMID: 19710502) Brunetta E. … Mavilio D. (Blood 2009) 3 23
  4. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. (PMID: 10499918) Falco M. … Moretta A. (J. Exp. Med. 1999) 3 4
  5. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. (PMID: 10611343) Vitale C. … Mingari M.C. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4

Products for SIGLEC7 Gene

Sources for SIGLEC7 Gene

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