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Aliases for SIGLEC7 Gene

Aliases for SIGLEC7 Gene

  • Sialic Acid Binding Ig Like Lectin 7 2 3 5
  • QA79 Membrane Protein 3 4
  • SIGLEC-7 3 4
  • D-Siglec 3 4
  • AIRM-1 3 4
  • CDw328 3 4
  • AIRM1 3 4
  • P75 3 4
  • Sialic Acid Binding Ig-Like Lectin 19, Pseudogene 2
  • Adhesion Inhibitory Receptor Molecule 1, Siglec-7 3
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 2 2
  • Sialic Acid Binding Immunoglobulin-Like Lectin 7 3
  • Adhesion Inhibitory Receptor Molecule 1 4
  • Sialic Acid Binding Ig-Like Lectin 7 2
  • Sialic Acid-Binding Ig-Like Lectin 7 3
  • CD328 Antigen 4
  • SIGLEC19P 3
  • P75/AIRM1 3
  • SIGLECP2 3
  • CD328 3
  • QA79 3

External Ids for SIGLEC7 Gene

Previous HGNC Symbols for SIGLEC7 Gene

  • SIGLEC19P
  • SIGLECP2

Previous GeneCards Identifiers for SIGLEC7 Gene

  • GC19P052276
  • GC19P052006
  • GC19P056321
  • GC19P056337
  • GC19P056299
  • GC19P051645
  • GC19P047978

Summaries for SIGLEC7 Gene

GeneCards Summary for SIGLEC7 Gene

SIGLEC7 (Sialic Acid Binding Ig Like Lectin 7) is a Protein Coding gene. Diseases associated with SIGLEC7 include Pheochromocytoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC12.

UniProtKB/Swiss-Prot for SIGLEC7 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Wiki entry for SIGLEC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC7 Gene

Genomics for SIGLEC7 Gene

Regulatory Elements for SIGLEC7 Gene

Enhancers for SIGLEC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051134 1.6 FANTOM5 Ensembl ENCODE 8.6 -2.2 -2194 10.6 TBP PKNOX1 NFRKB BCLAF1 KDM4B SMAD5 ZBTB11 GTF2B CEBPB ELF1 SIGLEC17P POLD1 CTU1 SIGLEC9 ZNF616 KLK14 KLK10 SIGLEC7 SIGLEC10 CD33
GH19F051460 1.5 FANTOM5 Ensembl ENCODE 7.6 +319.3 319307 2.4 ELF3 HDAC1 CBX3 TBL1XR1 CREB3L1 ZBTB40 ETS1 ZNF143 KDM4B CREM ZNF480 SIGLEC5 RPL7P51 SIGLEC14 SIGLEC6 SIGLEC8 SIGLEC7 ZNF175 ZNF613 CD33
GH19F051466 1.5 FANTOM5 Ensembl ENCODE 3 +325.8 325827 3.7 HDGF PKNOX1 ATF1 ARNT CREB3L1 SIN3A ELK1 CBX5 GATA2 ZNF143 SIGLEC6 ENSG00000269102 ZNF175 SIGLEC14 SIGLEC5 RPL7P51 ZNF766 FPR3 SIGLEC12 SIGLEC8
GH19F051570 0.9 FANTOM5 ENCODE 2.8 +429.9 429934 3.6 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B ZNF2 YY1 ZNF143 FOS ZNF175 ZNF480 SIGLEC14 SIGLEC5 RPL7P51 CEACAM18 ZNF808 SIGLEC8 SPACA6P-AS FPR3
GH19F051440 1.4 FANTOM5 Ensembl ENCODE 2.7 +299.3 299338 2.1 HDGF ATF1 PKNOX1 WRNIP1 SIN3A CBX5 ZNF143 JUNB TBX21 SMARCA4 SIGLEC6 SIGLEC7 ZNF649 ZNF175 SIGLEC9 SIGLEC10 ENSG00000269181 ENSG00000268711
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIGLEC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC7 Gene

Chromosome:
19
Start:
51,142,294 bp from pter
End:
51,153,526 bp from pter
Size:
11,233 bases
Orientation:
Plus strand

Genomic View for SIGLEC7 Gene

Genes around SIGLEC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC7 Gene

Proteins for SIGLEC7 Gene

  • Protein details for SIGLEC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y286-SIGL7_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 7
    Protein Accession:
    Q9Y286
    Secondary Accessions:
    • Q9NZQ1
    • Q9UJ86
    • Q9UJ87
    • Q9Y502

    Protein attributes for SIGLEC7 Gene

    Size:
    467 amino acids
    Molecular mass:
    51143 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAF44346.1; Type=Frameshift; Positions=406; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIGLEC7 Gene

    Alternative splice isoforms for SIGLEC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC7 Gene

Post-translational modifications for SIGLEC7 Gene

  • Tyrosine phosphorylated.
  • Glycosylation at Asn 105, Asn 142, Asn 165, Asn 229, Asn 235, Asn 242, Asn 260, and Asn 334
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC7 Gene

No data available for DME Specific Peptides for SIGLEC7 Gene

Domains & Families for SIGLEC7 Gene

Suggested Antigen Peptide Sequences for SIGLEC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y286

UniProtKB/Swiss-Prot:

SIGL7_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC7: view

Function for SIGLEC7 Gene

Molecular function for SIGLEC7 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 7,inhibitory receptor expressed in natural killer cells and monocytes,sialoadhesin,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Gene Ontology (GO) - Molecular Function for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10499918
GO:0030246 carbohydrate binding IEA,TAS --
genes like me logo Genes that share ontologies with SIGLEC7: view
genes like me logo Genes that share phenotypes with SIGLEC7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLEC7 Gene

Localization for SIGLEC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC7 Gene COMPARTMENTS Subcellular localization image for SIGLEC7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10567377
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC7: view

Pathways & Interactions for SIGLEC7 Gene

genes like me logo Genes that share pathways with SIGLEC7: view

Gene Ontology (GO) - Biological Process for SIGLEC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC7: view

No data available for SIGNOR curated interactions for SIGLEC7 Gene

Drugs & Compounds for SIGLEC7 Gene

(2) Drugs for SIGLEC7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-acetyl-alpha-D-glucosamine Experimental Pharma Target 0

(1) Additional Compounds for SIGLEC7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
genes like me logo Genes that share compounds with SIGLEC7: view

Transcripts for SIGLEC7 Gene

Unigene Clusters for SIGLEC7 Gene

Sialic acid binding Ig-like lectin 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5:

Relevant External Links for SIGLEC7 Gene

GeneLoc Exon Structure for
SIGLEC7
ECgene alternative splicing isoforms for
SIGLEC7

Expression for SIGLEC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC7 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC7 Gene

This gene is overexpressed in Whole Blood (x22.0) and Spleen (x9.2).

Protein differential expression in normal tissues from HIPED for SIGLEC7 Gene

This gene is overexpressed in NK cells (24.8), Monocytes (23.9), CD8 Tcells (6.5), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC7 Gene



Protein tissue co-expression partners for SIGLEC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC7 Gene:

SIGLEC7

SOURCE GeneReport for Unigene cluster for SIGLEC7 Gene:

Hs.655393

mRNA Expression by UniProt/SwissProt for SIGLEC7 Gene:

Q9Y286-SIGL7_HUMAN
Tissue specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SIGLEC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC7 Gene

Orthologs for SIGLEC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC7 34
  • 98.69 (n)
-- 35
  • 45 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Siglece 35
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 47 (a)
ManyToMany
Species where no ortholog for SIGLEC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC7 Gene

ENSEMBL:
Gene Tree for SIGLEC7 (if available)
TreeFam:
Gene Tree for SIGLEC7 (if available)

Paralogs for SIGLEC7 Gene

(9) SIMAP similar genes for SIGLEC7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SIGLEC7 Gene

genes like me logo Genes that share paralogs with SIGLEC7: view

Variants for SIGLEC7 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035523 A colorectal cancer sample
rs111261983 -- 51,143,273(+) CAGGC(A/C)AGGGA intron-variant
rs111486292 -- 51,144,813(+) GAGGA(C/T)GCTGG intron-variant
rs111638514 -- 51,150,389(+) TCTGC(A/G)TCTAT intron-variant
rs111660152 -- 51,153,753(+) CCTCA(A/C/T)GGGGG intron-variant, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC7 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC7 Gene

Disorders for SIGLEC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC7 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIGLEC7

Human Genome Epidemiology (HuGE) Navigator
SIGLEC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC7
genes like me logo Genes that share disorders with SIGLEC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC7 Gene

Publications for SIGLEC7 Gene

  1. Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. (PMID: 10567377) Nicoll G. … Crocker P.R. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. (PMID: 19710502) Brunetta E. … Mavilio D. (Blood 2009) 3 22 64
  3. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. (PMID: 16623661) Attrill H. … van Aalten D.M. (Biochem. J. 2006) 3 4 64
  4. Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. (PMID: 14747738) Dimasi N. … Mariuzza R.A. (Acta Crystallogr. D 2004) 3 4 64
  5. High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. (PMID: 12438315) Alphey M.S. … van Aalten D.M. (J. Biol. Chem. 2003) 3 4 64

Products for SIGLEC7 Gene

Sources for SIGLEC7 Gene

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