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Aliases for SIGLEC6 Gene

Aliases for SIGLEC6 Gene

  • Sialic Acid Binding Ig Like Lectin 6 2 3 5
  • Obesity-Binding Protein 1 3 4
  • CD33 Antigen-Like 1 3 4
  • CDW327 3 4
  • CD33L1 3 4
  • CD33L 3 4
  • OBBP1 3 4
  • Sialic Acid Binding Ig-Like Lectin 6 2
  • Sialic Acid-Binding Ig-Like Lectin 6 3
  • CD327 Antigen 4
  • Siglec-6 4
  • CD33L2 3
  • OB-BP1 4
  • CD327 3

External Ids for SIGLEC6 Gene

Previous HGNC Symbols for SIGLEC6 Gene

  • CD33L
  • CD33L1

Previous GeneCards Identifiers for SIGLEC6 Gene

  • GC19M052651
  • GC19M052382
  • GC19M056696
  • GC19M056712
  • GC19M052020
  • GC19M048355

Summaries for SIGLEC6 Gene

Entrez Gene Summary for SIGLEC6 Gene

  • This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

GeneCards Summary for SIGLEC6 Gene

SIGLEC6 (Sialic Acid Binding Ig Like Lectin 6) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot for SIGLEC6 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC6 Gene

Genomics for SIGLEC6 Gene

Regulatory Elements for SIGLEC6 Gene

Enhancers for SIGLEC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051545 2 FANTOM5 Ensembl ENCODE dbSUPER 23.1 -17.9 -17911 8.0 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 NFYC MEF2D NBN ZNF175 SIGLEC6 SIGLEC14 SIGLEC8 CEACAM18 SIGLEC12 RPL7P51 SIGLEC5 MIR125A MIR99B
GH19G051466 1.6 FANTOM5 Ensembl ENCODE 16.3 +64.2 64236 2.7 HDGF PKNOX1 ATF1 CREB3L1 SIN3A TCF12 ZNF766 ELK1 GATA2 CBX5 SIGLEC6 ZNF175 SIGLEC14 SIGLEC5 RPL7P51 FPR3 SIGLEC12 SIGLEC8 CD33 SIGLEC7
GH19G051565 1 FANTOM5 dbSUPER 17.4 -33.9 -33871 0.3 ZNF639 ESRRA ATF1 RNF2 NR2F1 HMBOX1 MLLT1 KDM1A ZEB2 SIGLEC6 ZNF175 CD33 SIGLEC8 SIGLEC12 SIGLEC7 SIGLEC29P
GH19G051460 1.5 FANTOM5 Ensembl ENCODE 10 +70.5 70463 2.0 CREB3L1 ARNT ETS1 ZNF143 KLF13 KDM4B NCOA1 ZNF518A ZNF592 KAT8 SIGLEC5 RPL7P51 SIGLEC14 SIGLEC6 SIGLEC8 SIGLEC7 ZNF175 ZNF613 SIGLEC10 CD33
GH19G051168 1.4 FANTOM5 Ensembl ENCODE 9.2 +362.5 362548 0.7 ATF1 ZNF2 RAD21 ZEB1 GLIS2 ZNF143 SIRT6 FOS ZNF654 USF2 SIGLEC6 SIGLEC8 SIGLEC17P LOC101928517
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIGLEC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC6 Gene

Chromosome:
19
Start:
51,519,525 bp from pter
End:
51,531,863 bp from pter
Size:
12,339 bases
Orientation:
Minus strand

Genomic View for SIGLEC6 Gene

Genes around SIGLEC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC6 Gene

Proteins for SIGLEC6 Gene

  • Protein details for SIGLEC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43699-SIGL6_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 6
    Protein Accession:
    O43699
    Secondary Accessions:
    • A8MV71
    • B2RTS8
    • C9JBE5
    • F8WA78
    • O15388
    • O43700

    Protein attributes for SIGLEC6 Gene

    Size:
    453 amino acids
    Molecular mass:
    49913 Da
    Quaternary structure:
    • Interacts with LEP.
    SequenceCaution:
    • Sequence=AAB70702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35359.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI40799.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24983.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24984.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIGLEC6 Gene

neXtProt entry for SIGLEC6 Gene

Post-translational modifications for SIGLEC6 Gene

  • Glycosylation at Asn103, isoforms=2, 3, 5, 6149, isoforms=2, 3, 4, 5, 6163, and Asn233
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SIGLEC6 (Siglec-6/CD327)
  • Abcam antibodies for SIGLEC6

No data available for DME Specific Peptides for SIGLEC6 Gene

Domains & Families for SIGLEC6 Gene

Suggested Antigen Peptide Sequences for SIGLEC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43699

UniProtKB/Swiss-Prot:

SIGL6_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC6: view

Function for SIGLEC6 Gene

Molecular function for SIGLEC6 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 6,expressed in placenta,spleen,peripheral blood leukocytes and small intestine,mediating cell-cell recognition,also binding leptin and potentially modulator of leptin levels,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Ontology (GO) - Molecular Function for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC6: view

Phenotypes for SIGLEC6 Gene

genes like me logo Genes that share phenotypes with SIGLEC6: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLEC6 Gene

Localization for SIGLEC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC6 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9465907
GO:0016020 membrane TAS 9465907
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC6: view

Pathways & Interactions for SIGLEC6 Gene

genes like me logo Genes that share pathways with SIGLEC6: view

Pathways by source for SIGLEC6 Gene

Gene Ontology (GO) - Biological Process for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007267 cell-cell signaling TAS 9465907
genes like me logo Genes that share ontologies with SIGLEC6: view

No data available for SIGNOR curated interactions for SIGLEC6 Gene

Drugs & Compounds for SIGLEC6 Gene

No Compound Related Data Available

Transcripts for SIGLEC6 Gene

Unigene Clusters for SIGLEC6 Gene

Sialic acid binding Ig-like lectin 6:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SIGLEC6 Gene

GeneLoc Exon Structure for
SIGLEC6
ECgene alternative splicing isoforms for
SIGLEC6

Expression for SIGLEC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC6 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC6 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.0), Esophagus - Muscularis (x4.3), Esophagus - Gastroesophageal Junction (x4.2), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for SIGLEC6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC6 Gene



Protein tissue co-expression partners for SIGLEC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC6 Gene:

SIGLEC6

SOURCE GeneReport for Unigene cluster for SIGLEC6 Gene:

Hs.720304

mRNA Expression by UniProt/SwissProt for SIGLEC6 Gene:

O43699-SIGL6_HUMAN
Tissue specificity: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
genes like me logo Genes that share expression patterns with SIGLEC6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC6 Gene

Orthologs for SIGLEC6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC6 34 35
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia SIGLEC6 35
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siglec5 35
  • 37 (a)
ManyToMany
Species where no ortholog for SIGLEC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC6 Gene

ENSEMBL:
Gene Tree for SIGLEC6 (if available)
TreeFam:
Gene Tree for SIGLEC6 (if available)

Paralogs for SIGLEC6 Gene

(10) SIMAP similar genes for SIGLEC6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIGLEC6 Gene

genes like me logo Genes that share paralogs with SIGLEC6: view

Variants for SIGLEC6 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs370040093 Uncertain significance 51,529,853(+) GGTGG(A/C/T)GTTCA intron-variant, nc-transcript-variant, reference, missense
rs1000167340 -- 51,518,955(+) CCTAC(A/T)CCTTT utr-variant-3-prime
rs1000175149 -- 51,521,605(+) AGGTG(A/G)AAATT intron-variant
rs1000191172 -- 51,525,499(+) CCGGG(-/C)CCCCA intron-variant
rs1000287960 -- 51,521,378(+) GTATA(-/TG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518

Variation tolerance for SIGLEC6 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC6 Gene

Disorders for SIGLEC6 Gene

Relevant External Links for SIGLEC6

Genetic Association Database (GAD)
SIGLEC6
Human Genome Epidemiology (HuGE) Navigator
SIGLEC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC6

No disorders were found for SIGLEC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC6 Gene

Publications for SIGLEC6 Gene

  1. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PMID: 9465907) Takei Y. … Nakamura Y. (Cytogenet. Cell Genet. 1997) 2 3 4 22 64
  2. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PMID: 18818296) Winn V.D. … Fisher S.J. (Endocrinology 2009) 3 22 64
  3. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PMID: 10428856) Patel N. … Kastelein R.A. (J. Biol. Chem. 1999) 3 4 64
  4. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. (PMID: 25320078) LAoubli H. … Varki A. (J. Biol. Chem. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for SIGLEC6 Gene

Sources for SIGLEC6 Gene

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