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SIGLEC6 Gene

protein-coding   GIFtS: 52
GCID: GC19M052020

Sialic Acid Binding Ig-Like Lectin 6


(Previous symbols: CD33L, CD33L1)
  See SIGLEC6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 61 2     CD33L22
CD33L1 2 3 5     CDW3272
CD33L11 2 3 5     Sialic Acid-Binding Ig-Like Lectin 62
OBBP12 3 5     CDw3273
Obesity-Binding Protein 12 3     OB-BP13
CD33 Antigen-Like 12 3     Siglec-63
CD3272     CD327 Antigen3

External Ids:    HGNC: 108751   Entrez Gene: 9462   Ensembl: ENSG000001054927   OMIM: 6044055   UniProtKB: O436993   

Export aliases for SIGLEC6 gene to outside databases

Previous GC identifers: GC19M052651 GC19M052382 GC19M056696 GC19M056712 GC19M048355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC6 Gene:
SIGLEC6 (sialic acid binding Ig-like lectin 6) is a protein-coding gene. Diseases associated with SIGLEC6 include obesity. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIGL6_HUMAN, O43699
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to
alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic
acids on the same cell surface




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC6 gene promoter:
         USF1   NRSF form 1   RelA   LUN-1   Ik-3   NF-kappaB   NRSF form 2   GATA-1   USF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC6 promoter sequence
   Search Chromatin IP Primers for SIGLEC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

SIGLEC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052020:  view genomic region     (about GC identifiers)

Start:
52,022,779 bp from pter      End:
52,035,110 bp from pter
Size:
12,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIGL6_HUMAN, O43699 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 6 precursor  
Size: 453 amino acids; 49913 Da
Subunit: Interacts with LEP
Sequence caution: Sequence=AAB70702.1; Type=Erroneous initiation; Sequence=AAH35359.2; Type=Erroneous initiation;
Sequence=AAI40799.1; Type=Erroneous initiation; Sequence=BAA24983.1; Type=Erroneous initiation;
Sequence=BAA24984.1; Type=Erroneous initiation;
Secondary accessions: A8MV71 B2RTS8 C9JBE5 F8WA78 O15388 O43700
Alternative splicing: 6 isoforms:  O43699-1   O43699-2   O43699-3   O43699-4   O43699-5   O43699-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIGLEC6: NX_O43699

Explore proteomics data for SIGLEC6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn103, Asn149, Asn163, Asn233
  • Modification sites at PhosphoSitePlus

  • See SIGLEC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001171018.1  NP_001171019.1  NP_001171020.1  NP_001236.4  NP_942142.3  NP_942143.3  

    ENSEMBL proteins: 
     ENSP00000344064   ENSP00000353071   ENSP00000410679   ENSP00000345907   ENSP00000401502  
     ENSP00000375674  

    SIGLEC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SIGLEC6 (Siglec-6/CD327)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SIGLEC6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SIGLEC6
    GenScript Custom Purified and Recombinant Proteins Services for SIGLEC6
    Novus Biologicals SIGLEC6 Proteins
    Novus Biologicals SIGLEC6 Lysates
    Sino Biological Recombinant Protein for SIGLEC6
    Sino Biological Cell Lysate for SIGLEC6
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIGLEC6

     
    Search eBioscience for Proteins for SIGLEC6 

    SIGLEC6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SIGLEC6 (Siglec-6/CD327)
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    Abcam antibodies for SIGLEC6
    Cloud-Clone Corp. Antibodies for SIGLEC6
    ThermoFisher Antibodies for SIGLEC6
    LSBio Antibodies in human, mouse, rat for SIGLEC6

    SIGLEC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SIGLEC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIGLEC6
    Cloud-Clone Corp. CLIAs for SIGLEC6
    Search eBioscience for ELISAs for SIGLEC6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry O43699

    ProtoNet protein and cluster: O43699

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: SIGL6_HUMAN, O43699
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIGLEC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL6_HUMAN, O43699
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to
    alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic
    acids on the same cell surface

         Genatlas biochemistry entry for SIGLEC6:
    sialic acid binding Ig-like lectin 6,expressed in placenta,spleen,peripheral blood leukocytes and small
    intestine,mediating cell-cell recognition,also binding leptin and potentially modulator of leptin
    levels,sialoadhesin family,Ig superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SIGLEC6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC6:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIGLEC6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIGLEC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIGLEC6

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate SIGLEC6
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SIGLEC6
    Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SIGLEC6

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SIGLEC6 (NM_198845)
    Sino Biological Human cDNA Clone for SIGLEC6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIGLEC6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIGL6_HUMAN, O43699: Isoform 1: Cell membrane; Single-pass type I membrane protein
    SIGL6_HUMAN, O43699: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton2
    cytosol2
    nucleus2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane TAS9465907
    GO:0016020membrane TAS9465907

    Find genes that share ontologies with SIGLEC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC6
    Interactions:

        GeneGlobe Interaction Network for SIGLEC6

    2 Interacting proteins for SIGLEC6 (O436993) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LEPP411593I2D: score=2 
    SH2D1AO608803I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007267cell-cell signaling TAS9465907

    Find genes that share ontologies with SIGLEC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC6 (SIGL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC6 gene (6 alternative transcripts): 
    NM_001177547.1  NM_001177548.1  NM_001177549.1  NM_001245.5  NM_198845.4  NM_198846.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346477 ENST00000359982 ENST00000436458 ENST00000343300 ENST00000425629
    ENST00000474054 ENST00000391797(uc002pwy.3 uc002pwz.3 uc010ydb.2 uc010ydc.2 uc002pxa.3 uc010eoz.2)
    ENST00000496422(uc010epa.2 uc010epb.2) ENST00000489837
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIGLEC6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SIGLEC6
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC6
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SIGLEC6 (NM_198845)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC6
    Primer
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    OriGene qPCR primer pairs and template standards for SIGLEC6
    OriGene qSTAR qPCR primer pairs in human, mouse for SIGLEC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SIGLEC6
      QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC6
      QuantiFast Probe-based Assays in human, mouse, rat SIGLEC6

    Selected AceView cDNA sequences (see all 48):

    CR600025 CR614233 BX114837 NM_198845 CA495365 NM_198846 NM_001245 BC035359 
    AV714551 CB961761 BX396073 BX369880 AU138048 BF109909 AL543769 CB992745 
    CF529873 BG623874 BX350045 AL542696 AL542471 N40753 D86358 BF436016 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC6 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                                                      
    SP2:                                                              -                                       
    SP3:                                                                                -     -               
    SP4:                                -                             -                                       
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for SIGLEC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTAATTTA
    SIGLEC6 Expression
    About this image


    SIGLEC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Placenta (Extraembryonic Tissues)
    SIGLEC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC6 Protein Expression

    UniProtKB/Swiss-Prot: SIGL6_HUMAN, O43699
    Tissue specificity: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower
    levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for SIGLEC6 (if available)
    TreeFam Gene Tree for SIGLEC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC6 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC142  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    10 SIMAP similar genes for SIGLEC6 using alignment to 1 protein entry:     SIGL6_HUMAN:
    SIGLEC14    SIGLEC12    SIGLEC7    SIGLEC9    SIGLEC11    SIGLEC10
    SIGLEC5    SIGLEC8    CD33    SIGLEC16

    Find genes that share paralogs with SIGLEC6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SIGLEC6
    PGOHUM00000234740 PGOHUM00000250613


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC6 (see all 378)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132302761,2
    C,F--52022287(+) GCTCAT/CGCCTG 6 -- ds50014Minor allele frequency- C:0.15NA CSA 126
    rs1922824371,2
    --52022405(+) TTAGCC/TGGGTG 6 -- ds50010--------
    rs106532441,2
    C--52022550(+) ctcag-/A/A   
       A
    /AAA
    aaaaa
    12 -- ds5001 cds10--------
    rs1829882321,2
    C--52022622(+) GACTTC/TATGAA 6 -- ds50010--------
    rs48028021,2
    C,F,A--52022765(+) TAAAGC/TGACTT 6 -- ds50018Minor allele frequency- T:0.07NA WA EA 504
    rs46052781,2
    H--52022944(+) tgttgG/Aaagtc 6 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs1872247711,2
    --52023029(+) GGGGAA/GGCCCT 6 -- ut310--------
    rs761547661,2
    C,F--52023115(+) GACACA/CAGGAG 6 -- ut312Minor allele frequency- C:0.04NA EA 240
    rs1155200911,2
    C,F--52023164(+) AGGGAC/TCAACC 6 -- ut311Minor allele frequency- T:0.03WA 118
    rs1998286211,2
    C,F--52023332(+) GACAAT/CTCCTC 6 -- ut311Minor allele frequency- C:0.01EU 1323

    HapMap Linkage Disequilibrium report for SIGLEC6 (52022779 - 52035110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SIGLEC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv638CNV CNV17122850
    nsv469584CNV Complex16826518
    dgv1109e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC6
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604405    OMIM disorders: --

    1 disease for SIGLEC6:    
    About MalaCards
    obesity


    Find genes that share disorders with SIGLEC6           About GenesLikeMe

    Genetic Association Database (GAD): SIGLEC6
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC6 (1 document)

    Export disorders for SIGLEC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SIGLEC6)
        Utopia: connect your pdf to the dynamic
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    1. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PubMed id 9465907)1, 2, 3, 9 Takei Y.... Nakamura Y. (Cytogenet. Cell Genet. 1997)
    2. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PubMed id 10428856)1, 2 Patel N.... Kastelein R.A. (J. Biol. Chem. 1999)
    3. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PubMed id 18818296)1, 9 Winn V.D....Fisher S.J. (Endocrinology 2009)
    4. Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia. (PubMed id 23171684)1 Rumer K.K....Winn V.D. (Reprod Sci 2013)
    5. Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion. (PubMed id 23089140)1 Rumer K.K....Winn V.D. (Endocr. Relat. Cancer 2012)
    6. Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway. (PubMed id 21880722)1 Lam K.K....Yeung W.S. (J. Biol. Chem. 2011)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Human-specific expression of Siglec-6 in the placenta. (PubMed id 17580316)1 Brinkman-Van der Linden E.C....Varki N. (Glycobiology 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 946 HGNC: 10875 AceView: SIGLEC6 Ensembl:ENSG00000105492 euGenes: HUgn946
    ECgene: SIGLEC6 H-InvDB: SIGLEC6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC6 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_273

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC6 gene:
    Search GeneIP for patents involving SIGLEC6

    GeneCards and IP:
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