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Aliases for SIGLEC6 Gene

Aliases for SIGLEC6 Gene

  • Sialic Acid Binding Ig Like Lectin 6 2 3 5
  • Obesity-Binding Protein 1 3 4
  • CD33 Antigen-Like 1 3 4
  • CDW327 3 4
  • CD33L1 3 4
  • CD33L 3 4
  • OBBP1 3 4
  • Sialic Acid Binding Ig-Like Lectin 6 2
  • Sialic Acid-Binding Ig-Like Lectin 6 3
  • CD327 Antigen 4
  • Siglec-6 4
  • CD33L2 3
  • OB-BP1 4
  • CD327 3

External Ids for SIGLEC6 Gene

Previous HGNC Symbols for SIGLEC6 Gene

  • CD33L
  • CD33L1

Previous GeneCards Identifiers for SIGLEC6 Gene

  • GC19M052651
  • GC19M052382
  • GC19M056696
  • GC19M056712
  • GC19M052020
  • GC19M048355

Summaries for SIGLEC6 Gene

Entrez Gene Summary for SIGLEC6 Gene

  • This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

GeneCards Summary for SIGLEC6 Gene

SIGLEC6 (Sialic Acid Binding Ig Like Lectin 6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC8.

UniProtKB/Swiss-Prot for SIGLEC6 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Additional gene information for SIGLEC6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC6 Gene

Genomics for SIGLEC6 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC6 Gene

Promoters and enhancers for SIGLEC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051531 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.2 152 1.4 HDAC1 IRF4 ZNF766 CBX5 BCLAF1 IKZF2 RUNX3 CREM ZNF263 ZNF592 SIGLEC6 SIGLEC12 CEACAM18 SIGLEC8 SIGLEC5 RPL7P51 SIGLEC14 ENSG00000268777
GH19I051545 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31.8 -17.9 -17910 8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A IRF4 POLR2B SIGLEC6 ZNF175 ZNF841 ZNF616 ZNF836 ZNF808 SIGLEC14 SIGLEC8 ZNF350 CEACAM18
GH19I051466 Enhancer 1.5 FANTOM5 Ensembl ENCODE 25.2 +64.2 64236 2.7 HDGF ATF1 PKNOX1 SMAD1 NCOA2 TCF12 POLR2B ZNF766 GATA2 E2F8 SIGLEC26P SIGLEC6 ZNF175 SIGLEC14 SIGLEC5 RPL7P51 FPR3 SIGLEC12 SIGLEC8 CD33
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -158.6 -158628 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I051360 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +166.9 166920 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ETFB CLDND2 ENSG00000268520 ZNF616 POLD1 ZNF766 ZNF836 ZNF841 ZNF577 ZNF175
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC6 gene promoter:

Genomic Locations for SIGLEC6 Gene

Genomic Locations for SIGLEC6 Gene
chr19:51,519,525-51,531,863
(GRCh38/hg38)
Size:
12,339 bases
Orientation:
Minus strand
chr19:52,022,779-52,035,110
(GRCh37/hg19)

Genomic View for SIGLEC6 Gene

Genes around SIGLEC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC6 Gene

Proteins for SIGLEC6 Gene

  • Protein details for SIGLEC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43699-SIGL6_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 6
    Protein Accession:
    O43699
    Secondary Accessions:
    • A8MV71
    • B2RTS8
    • C9JBE5
    • F8WA78
    • O15388
    • O43700

    Protein attributes for SIGLEC6 Gene

    Size:
    453 amino acids
    Molecular mass:
    49913 Da
    Quaternary structure:
    • Interacts with LEP.
    SequenceCaution:
    • Sequence=AAB70702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35359.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI40799.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24983.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA24984.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIGLEC6 Gene

neXtProt entry for SIGLEC6 Gene

Post-translational modifications for SIGLEC6 Gene

  • Glycosylation at posLast=103103, isoforms=2, 3, 5, 6149, isoforms=2, 3, 4, 5, 6163, and posLast=233233

No data available for DME Specific Peptides for SIGLEC6 Gene

Domains & Families for SIGLEC6 Gene

Gene Families for SIGLEC6 Gene

Suggested Antigen Peptide Sequences for SIGLEC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43699

UniProtKB/Swiss-Prot:

SIGL6_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC6: view

Function for SIGLEC6 Gene

Molecular function for SIGLEC6 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 6,expressed in placenta,spleen,peripheral blood leukocytes and small intestine,mediating cell-cell recognition,also binding leptin and potentially modulator of leptin levels,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Phenotypes From GWAS Catalog for SIGLEC6 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC6: view

Phenotypes for SIGLEC6 Gene

genes like me logo Genes that share phenotypes with SIGLEC6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC6 Gene

Localization for SIGLEC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC6 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 9465907
GO:0016020 membrane TAS 9465907
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC6 Gene

Pathways & Interactions for SIGLEC6 Gene

genes like me logo Genes that share pathways with SIGLEC6: view

Pathways by source for SIGLEC6 Gene

Gene Ontology (GO) - Biological Process for SIGLEC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007267 cell-cell signaling TAS 9465907
genes like me logo Genes that share ontologies with SIGLEC6: view

No data available for SIGNOR curated interactions for SIGLEC6 Gene

Drugs & Compounds for SIGLEC6 Gene

No Compound Related Data Available

Transcripts for SIGLEC6 Gene

Unigene Clusters for SIGLEC6 Gene

Sialic acid binding Ig-like lectin 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SIGLEC6 Gene

GeneLoc Exon Structure for
SIGLEC6
ECgene alternative splicing isoforms for
SIGLEC6

Expression for SIGLEC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC6 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC6 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.0), Esophagus - Muscularis (x4.3), Esophagus - Gastroesophageal Junction (x4.2), and Lung (x4.1).

Protein differential expression in normal tissues from HIPED for SIGLEC6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC6 Gene



Protein tissue co-expression partners for SIGLEC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC6 Gene:

SIGLEC6

SOURCE GeneReport for Unigene cluster for SIGLEC6 Gene:

Hs.720304

mRNA Expression by UniProt/SwissProt for SIGLEC6 Gene:

O43699-SIGL6_HUMAN
Tissue specificity: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
genes like me logo Genes that share expression patterns with SIGLEC6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC6 Gene

Orthologs for SIGLEC6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC6 33 34
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia SIGLEC6 34
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siglec5 34
  • 37 (a)
ManyToMany
Species where no ortholog for SIGLEC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC6 Gene

ENSEMBL:
Gene Tree for SIGLEC6 (if available)
TreeFam:
Gene Tree for SIGLEC6 (if available)

Paralogs for SIGLEC6 Gene

(10) SIMAP similar genes for SIGLEC6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIGLEC6 Gene

genes like me logo Genes that share paralogs with SIGLEC6: view

Variants for SIGLEC6 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs370040093 uncertain-significance, Malignant tumor of prostate 51,529,853(-) C/A/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000167340 -- 51,518,955(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000175149 -- 51,521,605(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000191172 -- 51,525,499(-) CCCCC/CCCC genic_downstream_transcript_variant, intron_variant
rs1000472378 -- 51,532,380(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC6 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv469584 CNV loss 16826518

Variation tolerance for SIGLEC6 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC6 Gene

Disorders for SIGLEC6 Gene

Additional Disease Information for SIGLEC6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SIGLEC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC6 Gene

Publications for SIGLEC6 Gene

  1. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PMID: 9465907) Takei Y … Nakamura Y (Cytogenetics and cell genetics 1997) 2 3 4 22 58
  2. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. (PMID: 18818296) Winn VD … Fisher SJ (Endocrinology 2009) 3 22 58
  3. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PMID: 10428856) Patel N … Kastelein RA (The Journal of biological chemistry 1999) 3 4 58
  4. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. (PMID: 25320078) Läubli H … Varki A (The Journal of biological chemistry 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SIGLEC6 Gene

Sources for SIGLEC6 Gene

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