Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGLEC5 Gene

protein-coding   GIFtS: 54
GCID: GC19M052114

sialic acid binding Ig-like lectin 5


(Previous symbol: CD33L2)
 Explore 6 diseases affiliated with
SIGLEC5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SIGLEC5    

Aliases
for SIGLEC5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sialic Acid Binding Ig-Like Lectin 51 2     CD33 Antigen-Like 22 3
CD33L21 2 3 5     OB-Binding Protein 22 3
OB-BP21 2 3     Sialic Acid-Binding Ig-Like Lectin 52
OBBP22 3 5     Sialic Acid-Binding Immunoglobulin-Like Lectin 52
CD1701 2     Siglec-53
SIGLEC-51 2     CD170 Antigen3
Obesity-Binding Protein 22 3     

External Ids:    HGNC: 108741   Entrez Gene: 87782   Ensembl: ENSG000001055017   OMIM: 6042005   UniProtKB: O153893   

Export aliases for SIGLEC5 gene to outside databases

Previous GC identifers: GC19M052745 GC19M052476 GC19M056791 GC19M056806


Summaries
for SIGLEC5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SIGLEC5:
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface
lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition
sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits
the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B
Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to
alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC5


Genomic Views
for SIGLEC5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGLEC5 gene promoter:
         GATA-3   CUTL1   Arnt   PPAR-gamma1   POU2F1   FOXO4   POU2F1a   ARP-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIGLEC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIGLEC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052114:  view genomic region     (about GC identifiers)

Start:
 52,114,781 bp from pter      End:
 52,150,151 bp from pter
Size:
 35,371 bases      Orientation:
 minus strand

Proteins
for SIGLEC5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 5 precursor  
Size: 551 amino acids; 60715 Da
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for SIGLEC5:
2ZG1 (3D)        2ZG2 (3D)        2ZG3 (3D)    

Explore the universe of human proteins at neXtProt for SIGLEC5: NX_O15389

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15389

    • SIGLEC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003821.1  
    ENSEMBL proteins: 
     ENSP00000455510   ENSP00000415200   ENSP00000222107  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SIGLEC5 (Siglec-5/CD170)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SIGLEC5
    OriGene Protein Over-expression Lysate: SIGLEC5
    OriGene Custom Protein Services for SIGLEC5 
    GenScript Custom Purified and Recombinant Proteins Services for SIGLEC5
    Novus Biologicals SIGLEC5 Protein
    Novus Biologicals SIGLEC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SIGLEC5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    SIGLEC5 for ontologies           About GeneDecksing



    SIGLEC5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SIGLEC5 (Siglec-5/CD170, Siglec-5/Siglec-14)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SIGLEC5 
    GenScript Custom Superior Antibodies Services for SIGLEC5
    Novus Biologicals SIGLEC5 Antibodies
    Abcam antibodies for SIGLEC5 
    Uscn Antibodies for SIGLEC5
    ThermoFisher Antibody for SIGLEC5

    Assay Products for SIGLEC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for SIGLEC5 (Siglec-5/CD170, Siglec-5/Siglec-14)         (see all)
    GenScript Custom Assay Services for SIGLEC5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SIGLEC5

    Protein Domains /
    Families
    for SIGLEC5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SIGLEC5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry O15389

    ProtoNet protein and cluster: O15389

    1 Blocks protein family: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif
    (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2
    domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for SIGLEC5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to
    alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
    with sialic acids on the same cell surface

         Genatlas biochemistry entry for SIGLEC5:
    sialic acid binding Ig-like lectin 5,expressed in neutrophils,with alternatively spliced transcripts,sialoadhesin
    family,Ig superfamily

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SIGLEC5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SIGLEC5:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: SIGLEC5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC5 (see all 7)
    OriGene shRNA RFP: SIGLEC5
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SIGLEC5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIGLEC5 (NM_003830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SIGLEC5
    Search LifeMap BioReagents cell lines for SIGLEC5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC5

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding ----


    SIGLEC5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SIGLEC5:
     Decreased influenza A/WSN/33 r 

    Animal Models:
         Mouse knock-out Siglec5tm1Lex for SIGLEC5
         1 MGI phenotypic allele for Siglec5 (no phenotypes)

    SIGLEC5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SIGLEC5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIGLEC5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for SIGLEC5 (O153892, 3 ENSP000004152004) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3, ENSP000001663454MINT-67771 I2D: score=5 STRING: ENSP00000166345
    TYROBPO439143, ENSP000002626294I2D: score=1 STRING: ENSP00000262629
    LEPP411593I2D: score=1 
    PTPN11Q061243I2D: score=1 
    PTPN6P293503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--


    SIGLEC5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SIGLEC5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SIGLEC5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIGLEC5
    2 Novoseek chemical compound relationships for SIGLEC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 51.5 1 18022638 (1)
    tyrosine 16.3 2 14617000 (1)

    Search CenterWatch for drugs/clinical trials and news about SIGLEC5 / SIGL5 

    Transcripts
    for SIGLEC5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SIGLEC5 gene: 
    NM_003830.3  

    Unigene Cluster for SIGLEC5:

    Sialic acid binding Ig-like lectin 5
    Hs.310333  [show with all ESTs]
    Unigene Representative Sequence: NM_003830
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570106 ENST00000429354(uc002pxe.3) ENST00000222107

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SIGLEC5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SIGLEC5:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: SIGLEC5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC5 (see all 7)
    OriGene shRNA RFP: SIGLEC5
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIGLEC5 (NM_003830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC5

    Additional cDNA sequence: 

    AF170484.1 AK225753.1 BC029896.1 U71383.1 

    5 DOTS entries:

    DT.207335  DT.121433273  DT.91718767  DT.121452074  DT.95233087 

    24/50 AceView cDNA sequences (see all 50):

    BI051310 BI050444 BM922784 AI471822 U71383 BI822428 BI756629 BV182078 
    BX643802 BX106622 BC029896 BI518761 BI906754 NM_003830 H71236 BI050447 
    BU101974 BX280873 BM922958 BU101663 BU102145 BI519714 AF170484 BV182177 

    GeneLoc Exon Structure


    Expression
    for SIGLEC5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIGLEC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SIGLEC5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SIGLEC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIGLEC5

    SOURCE GeneReport for Unigene cluster: Hs.310333

    UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
    Tissue specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes,
    spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by
    monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic
    differentiation

        SABiosciences Custom PCR Arrays for SIGLEC5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC5

    Orthologs
    for SIGLEC5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SIGLEC5 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 31(a)
    31(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343281.1(1573835-1580218)
    GL343281.1(1713612-1717084)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR548631.16
    si:ch211-171h4.56
    (see all 9)    		 si:ch211-171h4.5
    (see all 9)    		 21(a)
    18(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 4(948645-951913)
    19(11076841-11101335)


    ENSEMBL Gene Tree for SIGLEC5 (if available)
    TreeFam Gene Tree for SIGLEC5 (if available) 

    Paralogs
    for SIGLEC5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIGLEC5 gene
    CD332  SIGLEC17P2  SIGLEC82  SIGLEC162  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  
    MAG2  SIGLEC102  SIGLEC72  SIGLEC92  
    10 SIMAP similar genes for SIGLEC5 using alignment to 1 protein entry:     SIGL5_HUMAN:
    SIGLEC14    CD33    SIGLEC6    SIGLEC10    SIGLEC16    SIGLEC11
    SIGLEC8    SIGLEC9    SIGLEC12    SIGLEC7

    SIGLEC5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SIGLEC5
    PGOHUM00000234381 PGOHUM00000234735


    Genomic Variants
    for SIGLEC5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/423 NCBI SNPs in SIGLEC5 are shown (see all 423)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1487617531,2
    		Cother52115514(+) TACTCC/TGTGGT 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs1168943051,2
    		F,--52114353(+) AATCAA/GTGTCC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1141345701,2
    		C,F,--52114421(+) CTAACA/GTTGTC 1 -- ds50011Minor allele frequency- G:0.13WA 118
    rs743872051,2
    		C,F,--52114541(+) TAAGTT/CCTTTC 1 -- ds50011Minor allele frequency- C:0.14WA 118
    rs1444125841,2
    		--52114646(+) AGGAGA/GAGGAA 1 -- ds50010--------
    rs788541671,2
    		--52114688(+) CAGCAT/AGAAAG 1 -- ds50014Minor allele frequency- A:0.07CSA WA NA EA 360
    rs1487961501,2
    		--52114779(+) AGATGC/TTTGTG 1 -- ut310--------
    rs756897141,2
    		F,--52114806(+) CAGGGG/TGCCGT 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs1424187441,2
    		--52114809(+) GGGGCC/TGTGAA 1 -- ut310--------
    rs104148991,2
    		C,F,H,--52114901(+) GCCAAT/AGGAAT 1 -- ut3114Minor allele frequency- A:0.08NA WA CSA EA 377

    HapMap Linkage Disequilibrium report for SIGLEC5 (52114781 - 52150151 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for SIGLEC5
         13 CNVs: 37516 32263 35670 89297 67591 35671 4085 78251 89296 53829 78250 35672 0518

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC5
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC5

    Disorders / Diseases
    for SIGLEC5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SIGLEC5 for disorders           About GeneDecksing

    OMIM gene information: 604200    OMIM disorders: --

    6 diseases for SIGLEC5:    About MalaCards
    obesity    acute myeloid leukemia    myeloid leukemia    hepatitis b
    leukemia    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: SIGLEC5 (1 document)

    Export disorders for SIGLEC5 gene to outside databases

    Publications
    for SIGLEC5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIGLEC5 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SIGLEC5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. (PubMed id 10343116)1, 3, 9 Kim H.S. (1999)
    2. Structural implications of Siglec-5-mediated sialoglycan recognition. (PubMed id 18022638)1, 2, 9 Zhuravleva M.A.... Sun P.D. (2008)
    3. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. (PubMed id 9731071)1, 2, 9 Cornish A.L.... Crocker P.R. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PubMed id 10428856)1, 2 Patel N.... Kastelein R.A. (1999)
    7. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PubMed id 17012248)1, 9 Angata T.... Nakamura M. (2006)
    8. Leukocyte inflammatory responses provoked by pneumococ cal sialidase. (PubMed id 22215570)1 Chang Y.C....Nizet V. (2012)
    9. Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. (PubMed id 21795693)1 NordstrAPm T....Areschoug T. (2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

    External Searches for SIGLEC5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SIGLEC5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8778 HGNC: 10874 AceView: SIGLEC5 Ensembl:ENSG00000105501 euGenes: HUgn8778
    ECgene: SIGLEC5 H-InvDB: SIGLEC5

    Other Databases showing SIGLEC5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SIGLEC5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIGLEC5 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_272

    Intellectual Property
    for SIGLEC5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SIGLEC5 gene:
    Search GeneIP for patents involving SIGLEC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SIGLEC5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SIGLEC5 (Siglec-5/CD170)   Browse Cell Culture Products  
     ELISAs for SIGLEC5 (Siglec-5/CD170)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for SIGLEC5 (Siglec-5/CD170)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for SIGLEC5 (Siglec-5/CD170)  
     Browse OriGene Antibodies   OriGene shRNA RFP for SIGLEC5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC5  
     OriGene Protein Over-expression Lysate for SIGLEC5   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for SIGLEC5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SIGLEC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SIGLEC5   OriGene Custom Protein Services for SIGLEC5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC5
     GenScript Custom Purified and Recombinant Proteins Services for SIGLEC5 GenScript cDNA clones with any tag delivered in your preferred vector for SIGLEC5
     GenScript Custom Assay Services for SIGLEC5 GenScript Custom Superior Antibodies Services for SIGLEC5
     GenScript Custom overexpressing Cell Line Services for SIGLEC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SIGLEC5 promoter
     Search Chromatin IP Primers for SIGLEC5
     RT2 qPCR Primer Assay in human, mouse / rat SIGLEC5
     GNC Network for SIGLEC5
     SABiosciences Custom PCR Arrays for SIGLEC5
     Search Tocris compounds for SIGLEC5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SIGLEC5 antibodies
     SIGLEC5 proteins
     SIGLEC5 lysates
     Antibodies for SIGLEC5
     See all of Abcam's Antibodies, Kits and Proteins for SIGLEC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SIGLEC5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SIGLEC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC5
     SwitchGear 3'UTR luciferase reporter plasmids for SIGLEC5
     SwitchGear Promoter luciferase reporter plasmids for SIGLEC5
     ThermoFisher Antibody for SIGLEC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SIGLEC5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4