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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGLEC5 Gene

protein-coding   GIFtS: 52
GCID: GC19M052114

Sialic Acid Binding Ig-Like Lectin 5


(Previous symbol: CD33L2)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sialic Acid Binding Ig-Like Lectin 51 2     CD1702
CD33L21 2 3 5     SIGLEC-52
OBBP22 3 5     Sialic Acid-Binding Ig-Like Lectin 52
Obesity-Binding Protein 22 3     Sialic Acid-Binding Immunoglobulin-Like Lectin 52
OB-BP22 3     Siglec-53
CD33 Antigen-Like 22 3     CD170 Antigen3
OB-Binding Protein 22 3     

External Ids:    HGNC: 108741   Entrez Gene: 87782   Ensembl: ENSG000001055017   OMIM: 6042005   UniProtKB: O153893   

Export aliases for SIGLEC5 gene to outside databases

Previous GC identifers: GC19M052745 GC19M052476 GC19M056791 GC19M056806


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIGLEC5 Gene:
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell
surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid
recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of
Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils.
Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. (provided by
RefSeq, Feb 2012)

GeneCards Summary for SIGLEC5 Gene: 
SIGLEC5 (sialic acid binding Ig-like lectin 5) is a protein-coding gene. Diseases associated with SIGLEC5 include obesity, and acute myeloid leukemia. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to
alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis
interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGLEC5 gene promoter:
         GATA-3   CUTL1   Arnt   PPAR-gamma1   POU2F1   FOXO4   POU2F1a   ARP-1   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIGLEC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052114:  view genomic region     (about GC identifiers)

Start:
52,114,781 bp from pter      End:
52,150,151 bp from pter
Size:
35,371 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 5 precursor  
Size: 551 amino acids; 60715 Da
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for SIGLEC5:
2ZG1 (3D)        2ZG2 (3D)        2ZG3 (3D)    

Explore the universe of human proteins at neXtProt for SIGLEC5: NX_O15389

Explore proteomics data for SIGLEC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15389

  • SIGLEC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIGLEC5 Protein Expression
    REFSEQ proteins: NP_003821.1  
    ENSEMBL proteins: 
     ENSP00000473238   ENSP00000222107   ENSP00000455510  

    Human Recombinant Protein Products for SIGLEC5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SIGLEC5 (Siglec-5/CD170)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SIGLEC5
    OriGene Protein Over-expression Lysate for SIGLEC5
    OriGene MassSpec for SIGLEC5 
    OriGene Custom Protein Services for SIGLEC5
    GenScript Custom Purified and Recombinant Proteins Services for SIGLEC5
    Novus Biologicals SIGLEC5 Protein
    Novus Biologicals SIGLEC5 Lysate
    Sino Biological Recombinant Protein for SIGLEC5
    Sino Biological Cell Lysate for SIGLEC5 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIGLEC5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SIGLEC5 for ontologies           About GeneDecksing



    SIGLEC5 Antibody Products: 
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    GenScript Custom Assay Services for SIGLEC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIGLEC5 
    Cloud-Clone Corp. CLIAs for SIGLEC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SIGLEC: Sialic acid binding Ig-like lectins
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry O15389

    ProtoNet protein and cluster: O15389

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIGLEC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGL5_HUMAN, O15389
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to
    alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis
    interactions with sialic acids on the same cell surface

         Genatlas biochemistry entry for SIGLEC5:
    sialic acid binding Ig-like lectin 5,expressed in neutrophils,with alternatively spliced transcripts,sialoadhesin
    family,Ig superfamily

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SIGLEC5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC5:
     Decreased influenza A/WSN/33 r 

         1 MGI phenotypic allele for Siglec5 (no phenotypes)

    SIGLEC5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Siglec5tm1Lex for SIGLEC5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIGLEC5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIGLEC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIGLEC5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIGLEC5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SIGLEC5:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for SIGLEC5
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SIGLEC5

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SIGLEC5 (see all 7)
    OriGene ORF clones in mouse, rat for SIGLEC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIGLEC5 (NM_003830)
    Sino Biological Human cDNA Clone for SIGLEC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC5
    Sirion Biotech Customized lentivirus for stable overexpression of SIGLEC5 
                         Customized lentivirus expression plasmids for stable overexpression of SIGLEC5 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SIGLEC5
    Search LifeMap BioReagents cell lines for SIGLEC5
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIGLEC5

    5/6 Interacting proteins for SIGLEC5 (O153892, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156452, 3MINT-67771 I2D: score=5 
    LEPP411593I2D: score=1 
    PTPN11Q061243I2D: score=1 
    PTPN6P293503I2D: score=1 
    SH2D1AO608803I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    SIGLEC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SIGLEC5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIGLEC5 (SIGL5)

    2 Novoseek inferred chemical compound relationships for SIGLEC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 51.5 1 18022638 (1)
    tyrosine 16.3 2 14617000 (1)

    Search CenterWatch for drugs/clinical trials and news about SIGLEC5 / SIGL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIGLEC5 gene: 
    NM_003830.3  

    Unigene Cluster for SIGLEC5:

    Sialic acid binding Ig-like lectin 5
    Hs.310333  [show with all ESTs]
    Unigene Representative Sequence: NM_003830
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534261 ENST00000222107 ENST00000570106

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGLEC5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SIGLEC5:
    hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for SIGLEC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIGLEC5 (NM_003830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC5
    Sirion Biotech Customized lentivirus for stable overexpression of SIGLEC5 
                         Customized lentivirus expression plasmids for stable overexpression of SIGLEC5 
    Primer
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    OriGene qPCR primer pairs and template standards for SIGLEC5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC5

    Additional mRNA sequence: 

    AF170484.1 AK225753.1 BC029896.1 U71383.1 

    5 DOTS entries:

    DT.207335  DT.121433273  DT.91718767  DT.121452074  DT.95233087 

    24/50 AceView cDNA sequences (see all 50):

    BM922784 BI050444 BI051310 AI471822 BX643802 BU101663 BU102145 BI518761 
    BX106622 BX280873 BI050447 NM_003830 H71236 BI756629 BI822428 U71383 
    BV182078 BC029896 BU101974 BM922958 BI906754 BV182177 BI519714 BQ001464 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIGLEC5 expression in normal human tissues (normalized intensities)      SIGLEC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SIGLEC5 Expression
    About this image


    SIGLEC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             leukocytes   
     
     Tonsil (Hematopoietic System)
             tonsil ; non-germinal center cells   
     
     Placenta (Extraembryonic Tissues)
             placenta ; trophoblastic cells   
     
     Lymph (Hematopoietic System)
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)
             spleen ; cells in red pulp   

    See SIGLEC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIGLEC5

    SOURCE GeneReport for Unigene cluster: Hs.310333

    UniProtKB/Swiss-Prot: SIGL5_HUMAN, O15389
    Tissue specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood
    leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus.
    Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of
    myelomonocytic differentiation

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIGLEC5 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglec55 sialic acid binding Ig-like lectin 5   --   7 (28.25 cM) 43351341 


    ENSEMBL Gene Tree for SIGLEC5 (if available)
    TreeFam Gene Tree for SIGLEC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIGLEC5 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    8 SIMAP similar genes for SIGLEC5 using alignment to 1 protein entry:     SIGL5_HUMAN:
    SIGLEC14    CD33    SIGLEC6    SIGLEC10    SIGLEC16    SIGLEC11
    SIGLEC8    SIGLEC9

    SIGLEC5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SIGLEC5
    PGOHUM00000234381 PGOHUM00000234735


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/595 SNPs in SIGLEC5 are shown (see all 595)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487617531,2
    Cuntested152115514(+) TACTCC/TGTGGT 2 T syn11Minor allele frequency- T:0.00NA 4552
    VAR_0142494
    ----see VAR_0142492 V A mis40--------
    VAR_0142504
    ----see VAR_0142502 M V mis40--------
    rs1168943051,2
    C,F--52114353(+) AATCAA/GTGTCC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1141345701,2
    C,F--52114421(+) CTAACA/GTTGTC 1 -- ds50011Minor allele frequency- G:0.13WA 118
    rs743872051,2
    C,F--52114541(+) TAAGTT/CCTTTC 1 -- ds50011Minor allele frequency- C:0.14WA 118
    rs1444125841,2
    --52114646(+) AGGAGA/GAGGAA 1 -- ds50010--------
    rs788541671,2
    C,F--52114688(+) CAGCAT/AGAAAG 1 -- ds50014Minor allele frequency- A:0.07CSA WA NA EA 360
    rs1487961501,2
    --52114779(+) AGATGC/TTTGTG 1 -- ut310--------
    rs756897141,2
    C,F--52114806(+) CAGGGG/TGCCGT 1 -- ut311Minor allele frequency- T:0.03EA 120

    HapMap Linkage Disequilibrium report for SIGLEC5 (52114781 - 52150151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SIGLEC5 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv656e199CNV Deletion23128226
    esv2516533CNV Deletion19546169
    esv2659920CNV Deletion23128226
    nsv2534CNV Insertion18451855
    nsv2532CNV Loss18451855
    dgv593n67CNV Loss20364138
    esv27396CNV Loss19812545
    nsv458725CNV Loss19166990
    nsv9741CNV Loss18304495
    nsv181CNV Loss15895083

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC5
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604200    OMIM disorders: --

    6 diseases for SIGLEC5:    About MalaCards
    obesity    acute myeloid leukemia    myeloid leukemia    hepatitis b
    hepatitis    leukemia


    SIGLEC5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC5 (1 document)

    Export disorders for SIGLEC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC5 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SIGLEC5)
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    world of online information

    1. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. (PubMed id 10343116)1, 3, 9 Kim H.S. (1999)
    2. Structural implications of Siglec-5-mediated sialoglycan recognition. (PubMed id 18022638)1, 2, 9 Zhuravleva M.A.... Sun P.D. (2008)
    3. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. (PubMed id 9731071)1, 2, 9 Cornish A.L.... Crocker P.R. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PubMed id 10428856)1, 2 Patel N.... Kastelein R.A. (1999)
    7. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PubMed id 17012248)1, 9 Angata T.... Nakamura M. (2006)
    8. Refolded recombinant Siglec5 for NMR investigation of complex carbohydrate binding. (PubMed id 23321067)1 Barb A.W....Prestegard J.H. (2013)
    9. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. (PubMed id 22945238)1 Soto P.C....Varki A. (2013)
    10. Leukocyte inflammatory responses provoked by pneumococ cal sialidase. (PubMed id 22215570)1 Chang Y.C....Nizet V. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8778 HGNC: 10874 AceView: SIGLEC5 Ensembl:ENSG00000105501 euGenes: HUgn8778
    ECgene: SIGLEC5 H-InvDB: SIGLEC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC5 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_272

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC5 gene:
    Search GeneIP for patents involving SIGLEC5

    GeneCards and IP:
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