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Aliases for SIGLEC5 Gene

Aliases for SIGLEC5 Gene

  • Sialic Acid Binding Ig-Like Lectin 5 2 3
  • CD33L2 3 4 6
  • OBBP2 3 4 6
  • Obesity-Binding Protein 2 3 4
  • OB-Binding Protein 2 3 4
  • CD33 Antigen-Like 2 3 4
  • SIGLEC-5 3 4
  • OB-BP2 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 5 3
  • Sialic Acid-Binding Ig-Like Lectin 5 3
  • CD170 Antigen 4
  • CD170 3

External Ids for SIGLEC5 Gene

Previous Symbols for SIGLEC5 Gene

  • CD33L2

Summaries for SIGLEC5 Gene

Entrez Gene Summary for SIGLEC5 Gene

  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

GeneCards Summary for SIGLEC5 Gene

SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5) is a Protein Coding gene. Diseases associated with SIGLEC5 include obesity. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot for SIGLEC5 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC5 Gene

Genomics for SIGLEC5 Gene

Genomic Location for SIGLEC5 Gene

51,611,503 bp from pter
51,645,545 bp from pter
34,043 bases
Minus strand

Genomic View for SIGLEC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC5 Gene

Regulatory Elements for SIGLEC5 Gene

Proteins for SIGLEC5 Gene

  • Protein details for SIGLEC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 5
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SIGLEC5 Gene

    551 amino acids
    Molecular mass:
    60715 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SIGLEC5 Gene

neXtProt entry for SIGLEC5 Gene

Proteomics data for SIGLEC5 Gene at MOPED

Post-translational modifications for SIGLEC5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn100, Asn210, Asn231, Asn253, Asn328, Asn375, Asn384, and Asn393

Other Protein References for SIGLEC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC5 Gene

Domains for SIGLEC5 Gene

Gene Families for SIGLEC5 Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

Protein Domains for SIGLEC5 Gene


  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • O15389
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • O15389
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • O15389
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • O15389
genes like me logo Genes that share domains with SIGLEC5: view

Function for SIGLEC5 Gene

Molecular function for SIGLEC5 Gene

GENATLAS Biochemistry: sialic acid binding Ig-like lectin 5,expressed in neutrophils,with alternatively spliced transcripts,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Ontology (GO) - Molecular Function for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC5: view
genes like me logo Genes that share phenotypes with SIGLEC5: view

Animal Models for SIGLEC5 Gene

MGI Knock Outs for SIGLEC5:

miRNA for SIGLEC5 Gene

miRTarBase miRNAs that target SIGLEC5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIGLEC5 Gene

Localization for SIGLEC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC5 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC5: view

Pathways for SIGLEC5 Gene

SuperPathways for SIGLEC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC5: view

No data available for Pathways by source for SIGLEC5 Gene

Compounds for SIGLEC5 Gene

(2) Novoseek inferred chemical compound relationships for SIGLEC5 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 51.5 1
tyrosine 16.3 1
genes like me logo Genes that share compounds with SIGLEC5: view

Transcripts for SIGLEC5 Gene

mRNA/cDNA for SIGLEC5 Gene

Unigene Clusters for SIGLEC5 Gene

Sialic acid binding Ig-like lectin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC5 Gene

No ASD Table

Relevant External Links for SIGLEC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLEC5 Gene

mRNA expression in normal human tissues for SIGLEC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC5 Gene

This gene is overexpressed in Whole Blood (21.3), Testis (9.2), Spleen (7.6), and Small Intestine - Terminal Ileum (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC5 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC5 Gene Hs.310333

mRNA Expression by UniProt/SwissProt for SIGLEC5 Gene

Tissue specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation
genes like me logo Genes that share expressions with SIGLEC5: view

Orthologs for SIGLEC5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 95 (a)
(Bos Taurus)
Mammalia -- 37
  • 63 (a)
-- 37
  • 55 (a)
-- 37
  • 57 (a)
  • 76.05 (n)
  • 61.73 (a)
(Canis familiaris)
Mammalia -- 37
  • 62 (a)
-- 37
  • 57 (a)
  • 75.74 (n)
  • 62.22 (a)
(Mus musculus)
Mammalia Siglec5 16
Species with no ortholog for SIGLEC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC5 Gene

Gene Tree for SIGLEC5 (if available)
Gene Tree for SIGLEC5 (if available)

Paralogs for SIGLEC5 Gene

Selected SIMAP similar genes for SIGLEC5 Gene using alignment to 1 proteins: Pseudogenes for SIGLEC5 Gene

genes like me logo Genes that share paralogs with SIGLEC5: view

Variants for SIGLEC5 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs872629 -- 51,627,385(-) AGAGA(G/T)TGGCT intron-variant
rs1106476 -- 51,627,384(-) GAGAT(A/T)GGCTG intron-variant
rs1530878 -- 51,621,390(+) TGCCA(C/G)ATGAG intron-variant
rs1868950 -- 51,621,073(+) AGCTT(A/G)GCAAG intron-variant
rs1973019 - 51,630,039(+) CCACA(A/G)CCTCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC5 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
nsv469584 CNV Complex 16826518
dgv1110e1 CNV Complex 17122850
nsv510771 CNV Loss 20534489
nsv2532 CNV Loss 18451855
nsv181 CNV Loss 15895083
nsv912295 CNV Gain 21882294
nsv458725 CNV Loss 19166990
dgv424n27 CNV Loss 19166990
nsv2534 CNV Insertion 18451855
dgv593n67 CNV Loss 20364138
esv27396 CNV Loss 19812545
esv2659920 CNV Deletion 23128226
dgv656e199 CNV Deletion 23128226
nsv9741 CNV Loss 18304495
esv2516533 CNV Deletion 19546169

Relevant External Links for SIGLEC5 Gene

HapMap Linkage Disequilibrium report

Disorders for SIGLEC5 Gene

(1) MalaCards Diseases for SIGLEC5 Gene

Search for SIGLEC5 Gene in MalaCards »

Relevant External Links for SIGLEC5

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SIGLEC5: view

No data available for UniProtKB/Swiss-Prot for SIGLEC5 Gene

Publications for SIGLEC5 Gene

  1. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. (PMID: 9731071) Cornish A.L. … Crocker P.R. (Blood 1998) 3 4 23
  2. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. (PMID: 10343116) Kim H.S. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Structural implications of Siglec-5-mediated sialoglycan recognition. (PMID: 18022638) Zhuravleva M.A. … Sun P.D. (J. Mol. Biol. 2008) 3 4 23
  4. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily. (PMID: 10428856) Patel N. … Kastelein R.A. (J. Biol. Chem. 1999) 3 4
  5. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T. … Nakamura M. (FASEB J. 2006) 3 23

Products for SIGLEC5 Gene

Sources for SIGLEC5 Gene

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