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SIGLEC17P Gene

pseudogene   GIFtS: 21
GCID: GC19P051671

Sialic Acid Binding Ig-Like Lectin 17, Pseudogene

(Previous names: sialic acid binding Ig-like lectin, pseudogene 3)
(Previous symbol: SIGLECP3)
  Search for SIGLEC17P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 17, Pseudogene1 2
SIGLECP31 2
Sialic Acid Binding Ig-Like Lectin, Pseudogene 31
HSPC0782
SIGLECP22

External Ids:    HGNC: 156041   Entrez Gene: 2843672   Ensembl: ENSG000001711017   

Export aliases for SIGLEC17P gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC17P Gene:
SIGLEC17P (sialic acid binding Ig-like lectin 17, pseudogene) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SIGLEC17P
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC17P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC17P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC17P gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051671:  view genomic region     (about GC identifiers)

Start:
51,670,585 bp from pter      End:
51,676,780 bp from pter
Size:
6,196 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SIGLEC: Sialic acid binding Ig-like lectins

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC17P
Interactions:

    Search GeneGlobe Interaction Network for SIGLEC17P

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for SIGLEC17P



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for SIGLEC17P:

Sialic acid binding Ig-like lectin 17, pseudogene
Hs.132045  [show with all ESTs]
Unigene Representative Sequence: NR_047529
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000598286 ENST00000597135 ENST00000593736 ENST00000594781 ENST00000341811(uc010ycu.2 uc010ycv.2 uc002pvy.4 uc002pvz.4)
ENST00000305812
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Additional mRNA sequence: 

AF161341.1 AK301336.1 BC041072.1 BC050999.1 NR_047529.1 NR_047530.1 NR_047531.1 

2 DOTS entries:

DT.97836697  DT.100742348 

12 AceView cDNA sequences:

BM920861 BM564074 BC035688 AI040646 BQ072659 AF161341 BC050999 BM564076 
BC041072 AF150143 AI801574 AV742547 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC17P    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:                                -                                 
SP2:                                -           -                     
SP3:                                                                  


ECgene alternative splicing isoforms for SIGLEC17P

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SIGLEC17P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
SIGLEC17P Expression
About this image

SIGLEC17P Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SIGLEC17P Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.132045
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for SIGLEC17P (if available)
TreeFam Gene Tree for SIGLEC17P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SIGLEC17P (see all 204)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1451231611,2
--51668760(+) TGCTTC/TACTAT 3 -- us2k10--------
rs744691781,2
C--51668761(+) GCTTTA/TCTATT 3 -- us2k10--------
rs2003264531,2
--51668764(+) TTACT-/ATT   
  AAGACC
AAATT
3 -- us2k10--------
rs2004570671,2
--51668765(+) TACTA-/TTAAGAC 3 -- us2k10--------
rs2018899451,2
--51668769(+) ATTAA-/GAC   
   CAAAT
TATTG
3 -- us2k10--------
rs1832563041,2
--51668903(+) GGACAA/GATGAA 3 -- us2k10--------
rs1158134901,2
C,F--51669164(+) CAGCAC/TGATCA 3 -- us2k11Minor allele frequency- T:0.03WA 118
rs104149301,2
F,H--51669182(+) TGAGAT/CTtttt 3 -- us2k1 trp34Minor allele frequency- C:0.02NS EA 410
rs1877304401,2
C--51669238(+) TTGCCC/TAGGCT 3 -- us2k10--------
rs1468534581,2
C--51669265(+) ATCTCA/GGCTCA 3 -- us2k10--------

HapMap Linkage Disequilibrium report for SIGLEC17P (51670585 - 51676780 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SIGLEC17P: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing SIGLEC17P
DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC17P

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SIGLEC17P gene integrated from 10 sources:
(articles sorted by number of sources associating them with SIGLEC17P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. (PubMed id 22665810)1 Wang X....Varki A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  2. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. (PubMed id 11943481)1 Yousef G.M.... Diamandis E.P. (Gene 2002)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. A second uniquely human mutation affecting sialic acid biology. (PubMed id 11546777)1 Angata T.... Varki A. (J. Biol. Chem. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284367 HGNC: 15604 AceView: LOC284367 Ensembl:ENSG00000171101 euGenes: HUgn284367
ECgene: SIGLEC17P H-InvDB: SIGLEC17P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SIGLEC17P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SIGLEC17P gene:
Search GeneIP for patents involving SIGLEC17P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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