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Aliases for SIGLEC16 Gene

Aliases for SIGLEC16 Gene

  • Sialic Acid Binding Ig Like Lectin 16 (Gene/Pseudogene) 2 3
  • Sialic Acid Binding Ig-Like Lectin 16 (Gene/Pseudogene) 2 5
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 16 2 3
  • Siglec-P16 3 4
  • SIGLECP16 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 16 3
  • Sialic Acid Binding Ig-Like Lectin 16 3
  • Siglec-16 4

External Ids for SIGLEC16 Gene

Previous HGNC Symbols for SIGLEC16 Gene

  • SIGLECP16

Previous GeneCards Identifiers for SIGLEC16 Gene

  • GC19P055168
  • GC19P050473
  • GC19P046849

Summaries for SIGLEC16 Gene

GeneCards Summary for SIGLEC16 Gene

SIGLEC16 (Sialic Acid Binding Ig Like Lectin 16 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for SIGLEC16 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC16 Gene

Genomics for SIGLEC16 Gene

Regulatory Elements for SIGLEC16 Gene

Genomic Location for SIGLEC16 Gene

Chromosome:
19
Start:
49,969,655 bp from pter
End:
49,975,819 bp from pter
Size:
6,165 bases
Orientation:
Plus strand

Genomic View for SIGLEC16 Gene

Genes around SIGLEC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC16 Gene

Proteins for SIGLEC16 Gene

  • Protein details for SIGLEC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMB1-SIG16_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 16
    Protein Accession:
    A6NMB1

    Protein attributes for SIGLEC16 Gene

    Size:
    481 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIGLEC16 Gene

Proteomics data for SIGLEC16 Gene at MOPED

Post-translational modifications for SIGLEC16 Gene

  • Glycosylation at Asn 43, Asn 78, Asn 338, and Asn 347

No data available for DME Specific Peptides for SIGLEC16 Gene

Domains & Families for SIGLEC16 Gene

Protein Domains for SIGLEC16 Gene

Suggested Antigen Peptide Sequences for SIGLEC16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMB1

UniProtKB/Swiss-Prot:

SIG16_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC16: view

Function for SIGLEC16 Gene

Molecular function for SIGLEC16 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

miRNA for SIGLEC16 Gene

miRTarBase miRNAs that target SIGLEC16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC16 Gene

Localization for SIGLEC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC16 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC16: view

No data available for Subcellular locations from COMPARTMENTS for SIGLEC16 Gene

Pathways & Interactions for SIGLEC16 Gene

genes like me logo Genes that share pathways with SIGLEC16: view

Pathways by source for SIGLEC16 Gene

3 Reactome pathways for SIGLEC16 Gene

Interacting Proteins for SIGLEC16 Gene

Gene Ontology (GO) - Biological Process for SIGLEC16 Gene

None

No data available for SIGNOR curated interactions for SIGLEC16 Gene

Drugs & Compounds for SIGLEC16 Gene

No Compound Related Data Available

Transcripts for SIGLEC16 Gene

mRNA/cDNA for SIGLEC16 Gene

(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC16 Gene

No ASD Table

Relevant External Links for SIGLEC16 Gene

GeneLoc Exon Structure for
SIGLEC16
ECgene alternative splicing isoforms for
SIGLEC16

Expression for SIGLEC16 Gene

mRNA expression in normal human tissues for SIGLEC16 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC16 Gene

This gene is overexpressed in Ovary (x20.4), Spleen (x8.2), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for SIGLEC16 Gene

This gene is overexpressed in Synovial fluid (12.5), Placenta (12.4), Platelet (7.6), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC16 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC16 Gene Hs.568076

mRNA Expression by UniProt/SwissProt for SIGLEC16 Gene

A6NMB1-SIG16_HUMAN
Tissue specificity: Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.
genes like me logo Genes that share expression patterns with SIGLEC16: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for SIGLEC16 Gene

Orthologs for SIGLEC16 Gene

Evolution for SIGLEC16 Gene

ENSEMBL:
Gene Tree for SIGLEC16 (if available)
TreeFam:
Gene Tree for SIGLEC16 (if available)

No data available for Orthologs for SIGLEC16 Gene

Paralogs for SIGLEC16 Gene

(10) SIMAP similar genes for SIGLEC16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC16: view

No data available for Paralogs for SIGLEC16 Gene

Variants for SIGLEC16 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs440731 -- 49,969,964(+) AAGGA(C/G/T)GGACC nc-transcript-variant
rs377840 -- 49,970,165(-) GTTCA(C/G/T)GAAAC nc-transcript-variant
rs283508 -- 49,972,860(+) CAGTC(C/T)CCAAC intron-variant
rs402630 -- 49,970,273(+) GGGCT(C/T)TCAGG intron-variant
rs402653 -- 49,970,299(+) AGAAT(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC16 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
nsv7309 OTHER Inversion 18451855

Relevant External Links for SIGLEC16 Gene

HapMap Linkage Disequilibrium report
SIGLEC16
Human Gene Mutation Database (HGMD)
SIGLEC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SIGLEC16 Gene

Disorders for SIGLEC16 Gene

Relevant External Links for SIGLEC16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC16

No disorders were found for SIGLEC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC16 Gene

Publications for SIGLEC16 Gene

  1. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PMID: 18629938) Cao H. … Barrow A.D. (Eur. J. Immunol. 2008) 2 3 4 67
  2. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T. … Varki A. (J. Biol. Chem. 2002) 2 3
  3. Evolution of siglec-11 and siglec-16 genes in hominins. (PMID: 22383531) Wang X. … Varki A. (Mol. Biol. Evol. 2012) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for SIGLEC16 Gene

Sources for SIGLEC16 Gene

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