SIGLEC16 Gene
pseudogene GIFtS: 38
GCID: GC19P050473
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sialic acid binding Ig-like lectin 16 (gene/pseudogene)(Previous names: sialic acid binding Ig-like lectin, pseudogene 16 )
(Previous symbol: SIGLECP16)
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Aliases
for SIGLEC16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Sialic Acid Binding Ig-Like Lectin 16 (Gene/Pseudogene)1 2 | | SIGLECP161 2 3 | | Siglec-P161 2 3 | | Sialic Acid Binding Ig-Like Lectin, Pseudogene 161 | | Siglec-163 |
| External Ids: | HGNC: 248511 | Entrez Gene: 4007092 | Ensembl: ENSG000001616437 | UniProtKB: A6NMB13 | | ORGUL members: | |
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| NONCODE:n405659 n383530 | |
Export aliases for SIGLEC16 gene to outside databasesPrevious GC identifers: GC19P055168 GC19P046849
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Summaries
for SIGLEC16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SIG16_HUMAN, A6NMB1Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells (By similarity)
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Genomic Views
for SIGLEC16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIGLEC16 gene promoter:
E2F-3a E2F E2F-1 FOXO1a E2F-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIGLEC16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3SIGLEC16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050473: view genomic region
(about GC identifiers)
Start:
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50,472,857 bp from pter |
End:
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50,479,076 bp from pter |
Size:
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6,220 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
50472911 50475994 50479076 chr19
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Proteins
for SIGLEC16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: SIG16_HUMAN, A6NMB1 (See
protein sequence)Recommended Name: Sialic acid-binding Ig-like lectin 16 precursor Size: 481 amino acids; 52992 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Caution: According to PubMed:18629938, the SIGLECP16 sequence, that was initially classified as a pseudogene, has a 4bp deletion when compared with the sequence shown in this entry. This deletion is a polymorphism with a frequency ofaround 50% in the UK population. The frameshifted allele is non-functional whereas the sequence displayed here seemsto be functional. The functional allele has been named SIGLEC16 in PubMed:18629938Explore the universe of human proteins at neXtProt for SIGLEC16: NX_A6NMB1
SIGLEC16 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000396157 ENSP00000416930 Reactome Protein details: A6NMB1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
SIGLEC16 for ontologies About GeneDecksing
SIGLEC16 Antibody Products:
Assay Products for SIGLEC16: |
Protein
Domains /
Families
for SIGLEC16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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SIGLEC16 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry A6NMB1ProtoNet protein and cluster: A6NMB1 UniProtKB/Swiss-Prot: SIG16_HUMAN, A6NMB1Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIGLEC16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: SIG16_HUMAN, A6NMB1Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC16 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
-- | -- |
SIGLEC16 for ontologies About GeneDecksing
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Pathways & Interactions
for SIGLEC16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Immune System | | | 2 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for SIGLEC16
SIGLEC16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC16
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0007155 | cell adhesion |
IEA | -- |
SIGLEC16 for ontologies About GeneDecksing
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Drugs & Compounds
for SIGLEC16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for SIGLEC16
Search CenterWatch for drugs/clinical trials and news about SIGLEC16
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Transcripts
for SIGLEC16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Clusters for SIGLEC16: Sialic acid binding Ig-like lectin 16 (gene/pseudogene) Hs.568076 [show with all ESTs], Hs.738007 Unigene Representative Sequences: AK301031, BC0390082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417280 ENST00000456956(uc002prf.3 uc010ybj.1 uc010ybk.1)
Additional cDNA sequence: BC039008.1 EU330985.1 1 DOTS entry: DT.97792297 3 AceView cDNA sequences: BC030222 AI913240 BC039008
GeneLoc Exon Structure
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Expression
for SIGLEC16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIGLEC16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SIGLEC16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIGLEC16
SOURCE GeneReport for Unigene clusters: Hs.568076 Hs.738007
UniProtKB/Swiss-Prot: SIG16_HUMAN, A6NMB1Tissue specificity: Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain,macrophage, cancerous esophagus and lung at protein level
SABiosciences Custom PCR Arrays for SIGLEC16
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC16 |
Orthologs
for SIGLEC16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for SIGLEC16 (if available)
TreeFam Gene Tree for SIGLEC16 (if available) |
Paralogs
for SIGLEC16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIGLEC16 gene
- CD332 SIGLEC17P2 SIGLEC82 SIGLEC52 SIGLEC112 SIGLEC62 SIGLEC142 SIGLEC122
- MAG2 SIGLEC102 SIGLEC72 SIGLEC92
10 SIMAP similar genes for SIGLEC16 using alignment to 2 protein entries: SIG16_HUMAN (see all proteins):SIGLEC11 SIGLEC10 CD33 SIGLEC14 CEA SIGLEC7
SIGLEC12 SIGLEC5 SIGLEC6 SIGLEC8
SIGLEC16 for paralogs About GeneDecksing
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Genomic Variants
for SIGLEC16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SIGLEC16 (50472857 - 50479076 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SIGLEC16
1 CNV: 32261
2 Inversions: 37207 37208
Human Gene Mutation Database (HGMD): SIGLEC16
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC16 |
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Disorders
/ Diseases
for SIGLEC16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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SIGLEC16 for disorders About GeneDecksing
1  disease for SIGLEC16: About MalaCardspneumonia
Export disorders for SIGLEC16 gene to outside databases
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Publications
for SIGLEC16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for SIGLEC16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIGLEC16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PubMed id 18629938)1, 2, 3 Cao H....Barrow A.D. (2008)
- Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PubMed id 11986327)1, 2, 3 Angata T....Varki A. (2002)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A second uniquely human mutation affecting sialic acid biology. (PubMed id 11546777)1 Angata T.... Varki A. (2001)
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External Searches for SIGLEC16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SIGLEC16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing SIGLEC16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIGLEC16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SIGLEC16 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SIGLEC16 gene:
Search GeneIP for patents involving SIGLEC16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC16 |
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 | | | SIGLEC16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC16 |
|  |  |  | | | | Search ThermoFisher Antibodies for SIGLEC16 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC16 |
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