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Aliases for SIGLEC16 Gene

Aliases for SIGLEC16 Gene

  • Sialic Acid Binding Ig-Like Lectin 16 (Gene/Pseudogene) 2 3
  • Sialic Acid Binding Ig-Like Lectin, Pseudogene 16 2 3
  • Siglec-P16 3 4
  • SIGLECP16 3 4
  • Siglec-16 4

External Ids for SIGLEC16 Gene

Previous HGNC Symbols for SIGLEC16 Gene

  • SIGLECP16

Previous GeneCards Identifiers for SIGLEC16 Gene

  • GC19P055168
  • GC19P050473
  • GC19P046849

Summaries for SIGLEC16 Gene

GeneCards Summary for SIGLEC16 Gene

SIGLEC16 (Sialic Acid Binding Ig-Like Lectin 16 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by FGFR.

UniProtKB/Swiss-Prot for SIGLEC16 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC16 Gene

Genomics for SIGLEC16 Gene

Regulatory Elements for SIGLEC16 Gene

Genomic Location for SIGLEC16 Gene

Start:
49,969,655 bp from pter
End:
49,975,819 bp from pter
Size:
6,165 bases
Orientation:
Plus strand

Genomic View for SIGLEC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC16 Gene

Proteins for SIGLEC16 Gene

  • Protein details for SIGLEC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMB1-SIG16_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 16
    Protein Accession:
    A6NMB1
    Secondary Accessions:

    Protein attributes for SIGLEC16 Gene

    Size:
    481 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIGLEC16 Gene

Proteomics data for SIGLEC16 Gene at MOPED

Post-translational modifications for SIGLEC16 Gene

  • Glycosylation at Asn43, Asn78, Asn338, and Asn347

Other Protein References for SIGLEC16 Gene

Reactome Protein details:

No data available for DME Specific Peptides for SIGLEC16 Gene

Domains for SIGLEC16 Gene

Gene Families for SIGLEC16 Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SIGLEC16 Gene

Suggested Antigen Peptide Sequences for SIGLEC16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMB1

UniProtKB/Swiss-Prot:

SIG16_HUMAN :
  • A6NMB1
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC16: view

Function for SIGLEC16 Gene

Molecular function for SIGLEC16 Gene

UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells.

Gene Ontology (GO) - Molecular Function for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC16: view

miRNA for SIGLEC16 Gene

miRTarBase miRNAs that target SIGLEC16

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIGLEC16 Gene

Localization for SIGLEC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC16 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC16 Gene COMPARTMENTS Subcellular localization image for SIGLEC16 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC16: view

Pathways for SIGLEC16 Gene

SuperPathways for SIGLEC16 Gene

Superpath Contained pathways
1 Signaling by FGFR
genes like me logo Genes that share pathways with SIGLEC16: view

Pathways by source for SIGLEC16 Gene

1 Reactome pathway for SIGLEC16 Gene

Interacting Proteins for SIGLEC16 Gene

Gene Ontology (GO) - Biological Process for SIGLEC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC16: view

Transcripts for SIGLEC16 Gene

mRNA/cDNA for SIGLEC16 Gene

(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC16 Gene

No ASD Table

Relevant External Links for SIGLEC16 Gene

GeneLoc Exon Structure for
SIGLEC16
ECgene alternative splicing isoforms for
SIGLEC16

Expression for SIGLEC16 Gene

mRNA expression in normal human tissues for SIGLEC16 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC16 Gene

This gene is overexpressed in Ovary (20.4), Spleen (8.2), and Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SIGLEC16 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC16 Gene Hs.568076

mRNA Expression by UniProt/SwissProt for SIGLEC16 Gene

A6NMB1-SIG16_HUMAN
Tissue specificity: Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.
genes like me logo Genes that share expressions with SIGLEC16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC16 Gene

Orthologs for SIGLEC16 Gene

Evolution for SIGLEC16 Gene

ENSEMBL:
Gene Tree for SIGLEC16 (if available)
TreeFam:
Gene Tree for SIGLEC16 (if available)

No data available for Orthologs for SIGLEC16 Gene

Paralogs for SIGLEC16 Gene

Selected SIMAP similar genes for SIGLEC16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC16: view

No data available for Paralogs for SIGLEC16 Gene

Variants for SIGLEC16 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs283508 -- 49,972,860(+) CAGTC(C/T)CCAAC intron-variant
rs377840 -- 49,970,165(-) GTTCA(C/G)GAAAC nc-transcript-variant
rs385376 -- 49,970,676(+) CCAGC(A/G)GGACA intron-variant
rs389469 -- 49,971,451(+) CTCAG(G/T)GTCCC intron-variant
rs390053 -- 49,970,317(-) CTGGG(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC16 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
nsv7309 OTHER Inversion 18451855

Relevant External Links for SIGLEC16 Gene

HapMap Linkage Disequilibrium report
SIGLEC16
Human Gene Mutation Database (HGMD)
SIGLEC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC16 Gene

Disorders for SIGLEC16 Gene

No disorders were found for SIGLEC16 Gene.

No data available for UniProtKB/Swiss-Prot for SIGLEC16 Gene

Publications for SIGLEC16 Gene

  1. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T. … Varki A. (J. Biol. Chem. 2002) 2 3 4
  2. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PMID: 18629938) Cao H. … Barrow A.D. (Eur. J. Immunol. 2008) 2 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SIGLEC16 Gene

Sources for SIGLEC16 Gene

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