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SIGLEC15 Gene

protein-coding GIFtS: 47
GCID: GC18P043405

Sialic Acid Binding Ig-Like Lectin 15

(Previous names: CD33 antigen-like 3, CD33 molecule-like 3)
(Previous symbol: CD33L3)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 15¹ ²		HsT1361²
CD33L3¹ ² ³		SIGLEC-15²
CD33 Antigen-Like 3¹ ² ³		Sialic Acid-Binding Ig-Like Lectin 15²
CD33 Molecule-Like 3¹ ²		Siglec-15³

External Ids:	HGNC: 27596¹	Entrez Gene: 284266²	Ensembl: ENSG00000197046⁷	UniProtKB: Q6ZMC9³

Export aliases for SIGLEC15 gene to outside databases

Previous GC identifers: GC18P041660 GC18P040262

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC15 Gene:

SIGLEC15 (sialic acid binding Ig-like lectin 15) is a protein-coding gene.

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Function: Binds sialylated glycoproteins

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000018.9 NT_010966.15 NC_018929.2

Regulatory elements:

Regulatory transcription factor binding sites in the SIGLEC15 gene promoter:
AML1a HSF2 ARP-1 HSF1short HSF1 (long) ATF6 c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIGLEC15 promoter sequence

Search Chromatin IP Primers for SIGLEC15

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3 Ensembl cytogenetic band: 18q12.3 HGNC cytogenetic band: 18q21.1

SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC15 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P043405: view genomic region (about GC identifiers)

Start:	43,405,477 bp from pter	End:	43,424,045 bp from pter
Size:	18,569 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9 (See protein sequence)

Recommended Name: Sialic acid-binding Ig-like lectin 15 precursor

Size: 328 amino acids; 35653 Da

Subunit: Interacts with TYROBP and HCST

Secondary accessions: A8K2Y5

Explore the universe of human proteins at neXtProt for SIGLEC15: NX_Q6ZMC9

Explore proteomics data for SIGLEC15 at MOPED

Post-translational modifications:

Glycosylation² at Asn172

Modification sites at PhosphoSitePlus

See SIGLEC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_998767.1

ENSEMBL proteins:

ENSP00000374125 ENSP00000443509 ENSP00000466774

Reactome Protein details: Q6ZMC9

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

SIGLEC: Sialic acid binding Ig-like lectins

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q6ZMC9

ProtoNet protein and cluster: Q6ZMC9

1 Blocks protein domain: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Find genes that share domains with SIGLEC15 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SIG15_HUMAN, Q6ZMC9

Function: Binds sialylated glycoproteins

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

Find genes that share ontologies with SIGLEC15 About GenesLikeMe

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Siglec15):

cellular	hematopoietic system	homeostasis/metabolism	immune system	renal/urinary system
skeleton

Find genes that share phenotypes with SIGLEC15 About GenesLikeMe

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SIG15_HUMAN, Q6ZMC9: Membrane; Single-pass type I membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
extracellular	2
endoplasmic reticulum	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral component of membrane	IEA	--
GO:0043234	protein complex	IEA	--

Find genes that share ontologies with SIGLEC15 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SIGLEC15 About

See pathways by source

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by

SuperPath

Contained pathways About

Signaling by FGFR

DAP12 interactions

0.89

Find genes that share SuperPaths with SIGLEC15 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for SIGLEC15

DAP12 interactions

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Interactions:

Search GeneGlobe Interaction Network for SIGLEC15

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SIGLEC15 (ENSP00000374125⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000268500	ENSP00000415200⁴	STRING: ENSP00000415200
TYROBP	ENSP00000262629⁴	STRING: ENSP00000262629

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032956	regulation of actin cytoskeleton organization	IEA	--
GO:0045087	innate immune response	TAS	--
GO:0045124	regulation of bone resorption	IEA	--
GO:0071402	cellular response to lipoprotein particle stimulus	IEA	--
GO:2001204	regulation of osteoclast development	IEA	--

Find genes that share ontologies with SIGLEC15 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SIGLEC15 (SIG15)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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REFSEQ mRNAs for SIGLEC15 gene:

NM_213602.2

Unigene Cluster for SIGLEC15:

Sialic acid binding Ig-like lectin 15

Hs.287692 [show with all ESTs]

Unigene Representative Sequence: AK095432

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389474(uc002lbl.1 uc010xcp.1) ENST00000602118 ENST00000546268

ENST00000587418 ENST00000593178

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Additional mRNA sequence:

AK025833.1 AK092746.1 AK095432.1 AK172835.1 AK290400.1 AK290402.1 AK301189.1 AY971516.1

4 DOTS entries:

DT.99981522 DT.97815880 DT.97824933 DT.100011128

17 AceView cDNA sequences:

AK172835 AK095432 AI568147 NM_213602 BU174116 AK092746 AK025833 AX747704

BV194831 BQ773037 BM808284 BM423379 BU621715 AW769853 BU634236 BM916833

BE062674

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:					-
SP2:					-
SP3:									-		-

ECgene alternative splicing isoforms for SIGLEC15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SIGLEC15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCCCTGGGA

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SIGLEC15 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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SIGLEC15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.287692

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Siglec15^{1 , 5}	sialic acid binding Ig-like lectin 15^{1, 5}	85.65(n)¹ 84.18(a)¹		18 (52.43 cM)⁵ 620235¹ NM_001101038.1¹ NP_001094508.1¹ 78043614⁵
chicken (Gallus gallus)	Aves	SIGLEC15¹	sialic acid binding Ig-like lectin 15	57.96(n) 51.33(a)		770432 XM_001233765.2 XP_001233766.2
lizard (Anolis carolinensis)	Reptilia	SIGLEC15⁶	sialic acid binding Ig-like lectin 15	54(a)	1 ↔ 1	1(35256505-35258392)
tropical clawed frog (Xenopus tropicalis)	Amphibia	siglec15¹	sialic acid binding Ig-like lectin 15	53.54(n) 45(a)		100487460 XM_002936510.2 XP_002936556.2
zebrafish (Danio rerio)	Actinopterygii	si:dkey-11p23.7¹	si:dkey-11p23.7	50.52(n) 39.11(a)		100006927 NM_001102395.1 NP_001095865.1

ENSEMBL Gene Tree for SIGLEC15 (if available)
TreeFam Gene Tree for SIGLEC15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80080957^1,2	C,F	--	43403650(+)	`AAAGTC/TCTGTG`	1	--	us2k¹		1		EA	120
rs191819024^1,2	C	--	43403701(+)	`CCCAGA/GAAAAG`	1	--	us2k¹		0	--	--	--	--
rs182891925^1,2		--	43403858(+)	`GTGGCA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs185748597^1,2		--	43403909(+)	`ACCTTA/GTATCT`	1	--	us2k¹		0	--	--	--	--
rs9964592^1,2	C,F,A,H	--	43403930(+)	`AGGAAT/CGATAA`	1	--	us2k¹ tfbs³		5		NS EA WA	536
rs147284919^1,2		--	43403952(+)	`AATAAA/GTACAT`	1	--	us2k¹		0	--	--	--	--
rs139680602^1,2	C	--	43404120(+)	`CAGCCC/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs61543475^1,2		--	43404180(+)	`TTTTTA/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs149359559^1,2		--	43404195(+)	`GAGACA/GGAGTC`	1	--	us2k¹		0	--	--	--	--
rs182642833^1,2		--	43404306(+)	`AGCTGA/GGACTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIGLEC15 (43405477 - 43424045 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SIGLEC15: About this table

Variant ID	Type	Subtype	PubMed ID
nsv525268	CNV	Gain	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SIGLEC15

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SIGLEC15 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SIGLEC15)

Utopia: connect your pdf to the dynamic
world of online information

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PubMed id 17483134)^{1, 2, 3} Angata T.... Nakamura M. (Glycobiology 2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-I^ secretion from monocytes/macrophages through the DAP12-Syk pathway. (PubMed id 23035012)¹ Takamiya R....Angata T. (Glycobiology 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 284266	HGNC: 27596	AceView: CD33L3	Ensembl:ENSG00000197046	euGenes: HUgn284266
ECgene: SIGLEC15	H-InvDB: SIGLEC15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SIGLEC15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIGLEC15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SIGLEC15 gene:
Search GeneIP for patents involving SIGLEC15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	OriGene Antibodies for SIGLEC15		OriGene RNAi products in human, mouse, rat for SIGLEC15
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Hot genes Disease genes SIGLEC15 gene at Home site.

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SIGLEC15 Gene

Sialic Acid Binding Ig-Like Lectin 15

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SIGLEC15 Gene

Sialic Acid Binding Ig-Like Lectin 15

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SIGLEC15 Human Recombinant Protein Products:

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for SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene