SIGLEC15 Gene
protein-coding GIFtS: 47
GCID: GC18P043405
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Sialic Acid Binding Ig-Like Lectin 15(Previous names: CD33 antigen-like 3, CD33 molecule-like 3)
(Previous symbol: CD33L3)
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Aliases
for SIGLEC15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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| Aliases |
|---|
| Sialic Acid Binding Ig-Like Lectin 151 2 | | HsT13612 | | CD33L31 2 3 | | SIGLEC-152 | | CD33 Antigen-Like 31 2 3 | | Sialic Acid-Binding Ig-Like Lectin 152 | | CD33 Molecule-Like 31 2 | | Siglec-153 |
Export aliases for SIGLEC15 gene to outside databasesPrevious GC identifers: GC18P041660 GC18P040262 |
Summaries
for SIGLEC15 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for SIGLEC15 Gene:
SIGLEC15 (sialic acid binding Ig-like lectin 15) is a protein-coding gene. Diseases associated with SIGLEC15 include giant cell tumor.
UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9Function: Binds sialylated glycoproteins
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Genomic Views
for SIGLEC15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000018.10 NT_010966.15 NC_018929.2
Regulatory elements:
 Regulatory transcription factor binding sites in the SIGLEC15 gene promoter:
AML1a HSF2 ARP-1 HSF1short HSF1 (long) ATF6 c-Ets-1
Other transcription factors
Search Chromatin IP Primers for SIGLEC15
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q12.3 Ensembl cytogenetic band: 18q12.3 HGNC cytogenetic band: 18q21.1SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P043405: view genomic region
(about GC identifiers)
Start:
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43,405,477 bp from pter |
End:
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43,424,045 bp from pter |
Size:
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18,569 bases |
Orientation:
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plus strand |
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Proteins
for SIGLEC15 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9 (See
protein sequence)Recommended Name: Sialic acid-binding Ig-like lectin 15 precursor Size: 328 amino acids; 35653 Da
Subunit: Interacts with TYROBP and HCST
Secondary accessions: A8K2Y5Explore the universe of human proteins at neXtProt for SIGLEC15: NX_Q6ZMC9
Explore proteomics data for SIGLEC15 at MOPED
Post-translational modifications:  Glycosylation2 at Asn172 Modification sites at PhosphoSitePlus
See SIGLEC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_998767.1
ENSEMBL proteins: ENSP00000374125 ENSP00000443509 ENSP00000466774 Reactome Protein details: Q6ZMC9
SIGLEC15 Human Recombinant
Protein Products:SIGLEC15 Antibody
Products:SIGLEC15 Assay Products: |
Domains /
Families
for SIGLEC15 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
SIGLEC: Sialic acid binding Ig-like lectinsIGD: Immunoglobulin superfamily / Immunoglobulin-like domain containingVSET: Immunoglobulin superfamily / V-set domain containing
4 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q6ZMC9ProtoNet protein and cluster: Q6ZMC9 1 Blocks protein domain: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
SIGLEC15 for domains About GeneDecksing
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Function
for SIGLEC15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Molecular Function:
UniProtKB/Swiss-Prot Summary: SIG15_HUMAN, Q6ZMC9Function: Binds sialylated glycoproteins Gene Ontology (GO): 1 molecular function term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
SIGLEC15 for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Siglec15):
SIGLEC15 for phenotypes About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for SIGLEC15
| | | Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC15 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for SIGLEC15 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for SIGLEC15  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC15 |
Localization
for SIGLEC15 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot SIG15_HUMAN, Q6ZMC9: Membrane; Single-pass type I membrane proteinSubcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| plasma membrane | 4 | | extracellular | 2 | | endoplasmic reticulum | 1 |
Gene Ontology (GO): 3 cellular component terms: About this table
SIGLEC15 for ontologies About GeneDecksing
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Pathways & Interactions
for SIGLEC15 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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SuperPaths for SIGLEC15 About See pathways by source
Pathways by source See SuperPaths
Show all pathways
1  Reactome Pathway for SIGLEC15
SIGLEC15 for pathways About GeneDecksing
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC15
Interactions:
Search GeneGlobe Interaction Network for SIGLEC15
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SIGLEC15 (ENSP000003741254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032956 | regulation of actin cytoskeleton organization |
IEA | -- | | GO:0045087 | innate immune response |
TAS | -- | | GO:0045124 | regulation of bone resorption |
IEA | -- | | GO:0071402 | cellular response to lipoprotein particle stimulus |
IEA | -- | | GO:2001204 | regulation of osteoclast development |
IEA | -- |
SIGLEC15 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIGLEC15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for SIGLEC15 (SIG15)
|
Transcripts
for SIGLEC15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SIGLEC15 gene: NM_213602.2 Unigene Cluster for SIGLEC15: Sialic acid binding Ig-like lectin 15 Hs.287692 [show with all ESTs]Unigene Representative Sequence: AK0954325 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389474(uc002lbl.1 uc010xcp.1) ENST00000602118 ENST00000546268
ENST00000587418 ENST00000593178
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for SIGLEC15
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC15 |
Primer
Products: | | OriGene qPCR primer pairs and template standards for SIGLEC15
OriGene qSTAR qPCR primer pairs in human, mouse for SIGLEC15
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIGLEC15 | | | QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC15 | | | QuantiFast Probe-based Assays in human, mouse, rat SIGLEC15 |
Additional mRNA sequence: AK025833.1 AK092746.1 AK095432.1 AK172835.1 AK290400.1 AK290402.1 AK301189.1 AY971516.1 4 DOTS entries: DT.99981522 DT.97815880 DT.97824933 DT.100011128 17 AceView cDNA sequences: AK172835 AK095432 AI568147 NM_213602 BU174116 AK092746 AK025833 AX747704 BV194831 BQ773037 BM808284 BM423379 BU621715 AW769853 BU634236 BM916833 BE062674
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
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| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for SIGLEC15
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Expression
for SIGLEC15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | SIGLEC15 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCCCTGGGA
About this image SIGLEC15 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.287692
UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes
Custom PCR Arrays for SIGLEC15
Primer
Products: | | OriGene qPCR primer pairs and template standards for SIGLEC15
OriGene qSTAR qPCR primer pairs in human, mouse for SIGLEC15
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIGLEC15 | | | QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC15 | | | QuantiFast Probe-based Assays in human, mouse, rat SIGLEC15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC15 |
Orthologs
for SIGLEC15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for SIGLEC15 gene from Selected species (see all 10) About this table
ENSEMBL Gene Tree for SIGLEC15 (if available)
TreeFam Gene Tree for SIGLEC15 (if available) |
Paralogs
for SIGLEC15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | -- |
Genomic Variants
for SIGLEC15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIGLEC15 (43405477 - 43424045 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for SIGLEC15: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing SIGLEC15 |
|
Disorders
/ Diseases
for SIGLEC15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus | 1  disease for SIGLEC15: About MalaCardsgiant cell tumor
SIGLEC15 for disorders About GeneDecksing
Export disorders for SIGLEC15 gene to outside databases
|
Publications
for SIGLEC15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for SIGLEC15 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SIGLEC15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PubMed id 17483134)1, 2, 3 Angata T.... Nakamura M. (Glycobiology 2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-I^ secretion from monocytes/macrophages through the DAP12-Syk pathway. (PubMed id 23035012)1 Takamiya R....Angata T. (Glycobiology 2013)
|
External Searches for SIGLEC15 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing SIGLEC15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing SIGLEC15 gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing SIGLEC15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SIGLEC15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for SIGLEC15 gene:
Search GeneIP for patents involving SIGLEC15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat SIGLEC15 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing SIGLEC15 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC15 | | Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC15 | | | QuantiFast Probe-based Assays in human, mouse, rat SIGLEC15 | | QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC15 | | | Custom PCR Arrays for SIGLEC15 | | Search Chromatin IP Primers for SIGLEC15 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIGLEC15 | | Search GeneGlobe Interaction Network for SIGLEC15 | | | Regulatory tfbs in SIGLEC15 promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC15 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for SIGLEC15 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC15 |
| | | | LSBio Antibodies in human, mouse, rat for SIGLEC15 |
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