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Aliases for SIGLEC15 Gene

Aliases for SIGLEC15 Gene

  • Sialic Acid Binding Ig Like Lectin 15 2 3 5
  • CD33 Antigen-Like 3 2 3 4
  • CD33 Molecule-Like 3 2 3
  • SIGLEC-15 3 4
  • CD33L3 3 4
  • Sialic Acid Binding Ig-Like Lectin 15 2
  • Sialic Acid-Binding Ig-Like Lectin 15 3
  • HsT1361 3

External Ids for SIGLEC15 Gene

Previous HGNC Symbols for SIGLEC15 Gene

  • CD33L3

Previous GeneCards Identifiers for SIGLEC15 Gene

  • GC18P041660
  • GC18P043405
  • GC18P040262

Summaries for SIGLEC15 Gene

GeneCards Summary for SIGLEC15 Gene

SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling.

UniProtKB/Swiss-Prot for SIGLEC15 Gene

  • Binds sialylated glycoproteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC15 Gene

Genomics for SIGLEC15 Gene

Regulatory Elements for SIGLEC15 Gene

Enhancers for SIGLEC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G045801 1.4 Ensembl ENCODE dbSUPER 13.8 -22.5 -22512 3.6 PKNOX1 NFIB ZNF133 FEZF1 RAD21 GATA2 RCOR1 FOS USF2 CEBPB SIGLEC15 SLC14A1 EPG5 GC18P045808 ENSG00000267558
GH18G045773 1.3 Ensembl ENCODE dbSUPER 6.2 -50.6 -50616 2.6 TBP CBX3 RB1 FEZF1 RAD21 ZBTB40 YY1 ZNF143 IKZF2 SP3 SIGLEC15 LOC105372093 GC18M045733
GH18G045833 1 Ensembl ENCODE 7.5 +10.5 10523 4.7 CTCF PKNOX1 FOXA2 SUZ12 BHLHE40 MAX REST RBBP5 RAD21 ARID1B SIGLEC15 EPG5 GC18P045827 GC18M045898
GH18G045785 1 Ensembl ENCODE dbSUPER 7.5 -40.1 -40066 0.9 ZNF501 MAFK ZXDB SIGLEC15 EPG5 ENSG00000267558 LOC105372093
GH18G045771 0.8 FANTOM5 ENCODE 7.3 -53.6 -53586 1.0 ZFHX2 BHLHE40 SIGLEC15 SLC14A1 LOC105372093 GC18M045733
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC15 Gene

Chromosome:
18
Start:
45,825,512 bp from pter
End:
45,844,080 bp from pter
Size:
18,569 bases
Orientation:
Plus strand

Genomic View for SIGLEC15 Gene

Genes around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC15 Gene

Proteins for SIGLEC15 Gene

  • Protein details for SIGLEC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMC9-SIG15_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 15
    Protein Accession:
    Q6ZMC9
    Secondary Accessions:
    • A8K2Y5
    • B4DVQ9

    Protein attributes for SIGLEC15 Gene

    Size:
    328 amino acids
    Molecular mass:
    35653 Da
    Quaternary structure:
    • Interacts with TYROBP and HCST.

    Alternative splice isoforms for SIGLEC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC15 Gene

Post-translational modifications for SIGLEC15 Gene

  • Glycosylation at isoforms=2172
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC15 Gene

Domains & Families for SIGLEC15 Gene

Protein Domains for SIGLEC15 Gene

Suggested Antigen Peptide Sequences for SIGLEC15 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZMC9

UniProtKB/Swiss-Prot:

SIG15_HUMAN :
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC15: view

Function for SIGLEC15 Gene

Molecular function for SIGLEC15 Gene

UniProtKB/Swiss-Prot Function:
Binds sialylated glycoproteins.
genes like me logo Genes that share phenotypes with SIGLEC15: view

Animal Models for SIGLEC15 Gene

MGI Knock Outs for SIGLEC15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC15 Gene

Localization for SIGLEC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC15 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

Pathways & Interactions for SIGLEC15 Gene

genes like me logo Genes that share pathways with SIGLEC15: view

Pathways by source for SIGLEC15 Gene

3 Reactome pathways for SIGLEC15 Gene

Gene Ontology (GO) - Biological Process for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032956 regulation of actin cytoskeleton organization IEA --
GO:0045087 innate immune response TAS --
GO:0045124 regulation of bone resorption IEA --
GO:0071402 cellular response to lipoprotein particle stimulus IEA --
GO:2001204 regulation of osteoclast development IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

No data available for SIGNOR curated interactions for SIGLEC15 Gene

Drugs & Compounds for SIGLEC15 Gene

No Compound Related Data Available

Transcripts for SIGLEC15 Gene

mRNA/cDNA for SIGLEC15 Gene

Unigene Clusters for SIGLEC15 Gene

Sialic acid binding Ig-like lectin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - -

Relevant External Links for SIGLEC15 Gene

GeneLoc Exon Structure for
SIGLEC15
ECgene alternative splicing isoforms for
SIGLEC15

Expression for SIGLEC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC15 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC15 Gene

This gene is overexpressed in Bladder (x10.5), Whole Blood (x4.6), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SIGLEC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.9) and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC15 Gene



Protein tissue co-expression partners for SIGLEC15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC15 Gene:

SIGLEC15

SOURCE GeneReport for Unigene cluster for SIGLEC15 Gene:

Hs.287692

mRNA Expression by UniProt/SwissProt for SIGLEC15 Gene:

Q6ZMC9-SIG15_HUMAN
Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.

Evidence on tissue expression from TISSUES for SIGLEC15 Gene

  • Blood(4)
  • Liver(4)
  • Spleen(4)
genes like me logo Genes that share expression patterns with SIGLEC15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC15 Gene

Orthologs for SIGLEC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC15 34 35
  • 98.48 (n)
cow
(Bos Taurus)
Mammalia SIGLEC15 34 35
  • 86.18 (n)
mouse
(Mus musculus)
Mammalia Siglec15 34 16 35
  • 85.65 (n)
rat
(Rattus norvegicus)
Mammalia Siglec15 34
  • 83.65 (n)
dog
(Canis familiaris)
Mammalia SIGLEC15 34 35
  • 83.43 (n)
oppossum
(Monodelphis domestica)
Mammalia SIGLEC15 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIGLEC15 34 35
  • 57.96 (n)
lizard
(Anolis carolinensis)
Reptilia SIGLEC15 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siglec15 34
  • 53.54 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11p23.7 34
  • 50.52 (n)
SIGLEC15 35
  • 34 (a)
OneToOne
Species where no ortholog for SIGLEC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGLEC15 Gene

ENSEMBL:
Gene Tree for SIGLEC15 (if available)
TreeFam:
Gene Tree for SIGLEC15 (if available)

Paralogs for SIGLEC15 Gene

No data available for Paralogs for SIGLEC15 Gene

Variants for SIGLEC15 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC15 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000135281 -- 45,829,617(+) TGCCA(-/C)CCCCC intron-variant
rs1000146526 -- 45,828,474(+) GGTCT(A/G)GGAGC intron-variant
rs1000192772 -- 45,841,457(+) TCACT(C/G)AATGG intron-variant
rs1000679785 -- 45,834,381(+) CAAGA(C/T)ACACA intron-variant
rs1000846482 -- 45,833,184(+) AAAAC(G/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC15 Gene

Variant ID Type Subtype PubMed ID
dgv613e214 CNV gain 21293372
esv3642417 CNV loss 21293372
esv3893100 CNV gain 25118596
nsv525268 CNV gain 19592680

Variation tolerance for SIGLEC15 Gene

Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Disorders for SIGLEC15 Gene

Relevant External Links for SIGLEC15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC15

No disorders were found for SIGLEC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC15 Gene

Publications for SIGLEC15 Gene

  1. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PMID: 17483134) Angata T. … Nakamura M. (Glycobiology 2007) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-I^ secretion from monocytes/macrophages through the DAP12-Syk pathway. (PMID: 23035012) Takamiya R. … Angata T. (Glycobiology 2013) 3 64
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64

Products for SIGLEC15 Gene

Sources for SIGLEC15 Gene

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