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SIGLEC15 Gene(Protein Coding)

Sialic Acid Binding Ig Like Lectin 15

GCID:
GC18P045825
GIFtS:
46
Genes Participants
UDN Logo

Aliases for SIGLEC15 Gene

Aliases for SIGLEC15 Gene

  • Sialic Acid Binding Ig Like Lectin 15 2 3
  • Sialic Acid Binding Ig-Like Lectin 15 2 3 5
  • CD33 Antigen-Like 3 2 3 4
  • CD33 Molecule-Like 3 2 3
  • SIGLEC-15 3 4
  • CD33L3 3 4
  • HsT1361 3

External Ids for SIGLEC15 Gene

Previous HGNC Symbols for SIGLEC15 Gene

  • CD33L3

Previous GeneCards Identifiers for SIGLEC15 Gene

  • GC18P041660
  • GC18P043405
  • GC18P040262

Summaries for SIGLEC15 Gene

GeneCards Summary for SIGLEC15 Gene

SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling.

UniProtKB/Swiss-Prot for SIGLEC15 Gene

  • Binds sialylated glycoproteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC15 Gene

Genomics for SIGLEC15 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SIGLEC15 Gene

Enhancers for SIGLEC15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Promoters for SIGLEC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SIGLEC15 gene promoter:

Genomic Location for SIGLEC15 Gene

Chromosome:
18
Start:
45,825,512 bp from pter
End:
45,844,080 bp from pter
Size:
18,569 bases
Orientation:
Plus strand

Genomic View for SIGLEC15 Gene

Genes around SIGLEC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SIGLEC15 Gene

Proteins for SIGLEC15 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SIGLEC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMC9-SIG15_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 15
    Protein Accession:
    Q6ZMC9
    Secondary Accessions:
    • A8K2Y5
    • B4DVQ9

    Protein attributes for SIGLEC15 Gene

    Size:
    328 amino acids
    Molecular mass:
    35653 Da
    Quaternary structure:
    • Interacts with TYROBP and HCST.

    Alternative splice isoforms for SIGLEC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC15 Gene

Proteomics data for SIGLEC15 Gene at MOPED

Protein Expression for SIGLEC15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SIGLEC15 Gene

  • Glycosylation at Asn 172
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SIGLEC15 Gene

Domains & Families for SIGLEC15 Gene

Gene Families for SIGLEC15 Gene

HGNC:

Protein Domains for SIGLEC15 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SIGLEC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMC9

UniProtKB/Swiss-Prot:

SIG15_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC15: view

Function for SIGLEC15 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SIGLEC15 Gene

UniProtKB/Swiss-Prot Function:
Binds sialylated glycoproteins.

Phenotypes for SIGLEC15 Gene

MGI mutant phenotypes for SIGLEC15:
inferred from 1 alleles
GenomeRNAi human phenotypes for SIGLEC15:
genes like me logo Genes that share phenotypes with SIGLEC15: view

Animal Models for SIGLEC15 Gene

MGI Knock Outs for SIGLEC15:

Animal Model Products

miRNA for SIGLEC15 Gene

miRTarBase miRNAs that target SIGLEC15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC15 Gene

Localization for SIGLEC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC15 Gene COMPARTMENTS Subcellular localization image for SIGLEC15 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC15: view

Pathways & Interactions for SIGLEC15 Gene

genes like me logo Genes that share pathways with SIGLEC15: view

Pathways by source for SIGLEC15 Gene

3 Reactome pathways for SIGLEC15 Gene

Interacting Proteins for SIGLEC15 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374125%0d%0a9606.ENSP00000354090%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000412361%0d%0a
Selected Interacting proteins: ENSP00000374125 for SIGLEC15 Gene via STRING

Gene Ontology (GO) - Biological Process for SIGLEC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045124 regulation of bone resorption IEA --
GO:0071402 cellular response to lipoprotein particle stimulus IEA --
GO:2001204 regulation of osteoclast development IEA --
genes like me logo Genes that share ontologies with SIGLEC15: view

No data available for SIGNOR curated interactions for SIGLEC15 Gene

Drugs & Compounds for SIGLEC15 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SIGLEC15 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SIGLEC15 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC15 Gene

Sialic acid binding Ig-like lectin 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2: -
SP3: - -

Relevant External Links for SIGLEC15 Gene

GeneLoc Exon Structure for
SIGLEC15
ECgene alternative splicing isoforms for
SIGLEC15

Expression for SIGLEC15 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SIGLEC15 Gene

mRNA expression in normal human tissues for SIGLEC15 Gene
mRNA expression by BioGPS for SIGLEC15 GenemRNA expression by GTEx for SIGLEC15 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC15 Gene

This gene is overexpressed in Bladder (x10.5), Whole Blood (x4.6), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SIGLEC15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (61.9) and Breast (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC15 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC15 Gene Hs.287692

mRNA Expression by UniProt/SwissProt for SIGLEC15 Gene

Q6ZMC9-SIG15_HUMAN
Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
genes like me logo Genes that share expression patterns with SIGLEC15: view

Protein tissue co-expression partners for SIGLEC15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC15 Gene

Orthologs for SIGLEC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SIGLEC15 35
  • 86.18 (n)
  • 83.54 (a)
SIGLEC15 36
  • 83 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SIGLEC15 35
  • 83.43 (n)
  • 78.35 (a)
SIGLEC15 36
  • 79 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Siglec15 35
  • 85.65 (n)
  • 84.18 (a)
Siglec15 16
Siglec15 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SIGLEC15 35
  • 98.48 (n)
  • 97.56 (a)
SIGLEC15 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Siglec15 35
  • 83.65 (n)
  • 83.23 (a)
oppossum
(Monodelphis domestica)
 Mammalia SIGLEC15 36
  • 54 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SIGLEC15 35
  • 57.96 (n)
  • 51.33 (a)
SIGLEC15 36
  • 43 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SIGLEC15 36
  • 54 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia siglec15 35
  • 53.54 (n)
  • 45 (a)
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-11p23.7 35
  • 50.52 (n)
  • 39.11 (a)
SIGLEC15 36
  • 34 (a)
 OneToOne
Species with no ortholog for SIGLEC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGLEC15 Gene

ENSEMBL:
Gene Tree for SIGLEC15 (if available)
TreeFam:
Gene Tree for SIGLEC15 (if available)

Paralogs for SIGLEC15 Gene

No data available for Paralogs for SIGLEC15 Gene

Variants for SIGLEC15 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC15 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_033174 -

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC15 Gene

Variant ID Type Subtype PubMed ID
nsv525268 CNV Gain 19592680

Variation tolerance for SIGLEC15 Gene

Gene Damage Index Score: 9.70; 89.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIGLEC15 Gene

Disorders for SIGLEC15 Gene

Relevant External Links for SIGLEC15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC15

No disorders were found for SIGLEC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC15 Gene

Publications for SIGLEC15 Gene

  1. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PMID: 17483134) Angata T. … Nakamura M. (Glycobiology 2007) 2 3 4 67
  2. The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-I^ secretion from monocytes/macrophages through the DAP12-Syk pathway. (PMID: 23035012) Takamiya R. … Angata T. (Glycobiology 2013) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SIGLEC15 Gene

Sources for SIGLEC15 Gene

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