Aliases for SIGLEC15 Gene
Aliases for SIGLEC15 Gene
External Ids for SIGLEC15 Gene
- HGNC: 27596
- Entrez Gene: 284266
- Ensembl: ENSG00000197046
- UniProtKB: Q6ZMC9
Previous HGNC Symbols for SIGLEC15 Gene
- CD33L3
Previous GeneCards Identifiers for SIGLEC15 Gene
- GC18P041660
- GC18P043405
- GC18P040262
Summaries for SIGLEC15 Gene
GeneCards Summary for SIGLEC15 Gene
SIGLEC15 (Sialic Acid Binding Ig Like Lectin 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling.
UniProtKB/Swiss-Prot for SIGLEC15 Gene
-
Binds sialylated glycoproteins.
Additional gene information for SIGLEC15 Gene
- Monarch Initiative
- Search for SIGLEC15 at DataMed
- Search for SIGLEC15 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC15 Gene
Genomics for SIGLEC15 Gene
GeneHancer (GH) Regulatory Elements for SIGLEC15 Gene
Promoters and enhancers for SIGLEC15 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18I045825 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +0.3 | 289 | 0.8 | ZFHX2 ZNF366 IKZF1 IKZF2 EGR2 | GC18P045827 SIGLEC15 EPG5 | |
| GH18I045801 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 13.8 | -22.5 | -22511 | 3.6 | PKNOX1 CLOCK NFIB ZNF133 NEUROD1 NFXL1 FOS RCOR1 USF2 CEBPB | SIGLEC15 SLC14A1 EPG5 GC18P045808 ENSG00000267558 | |
| GH18I045773 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 6.3 | -50.6 | -50616 | 2.6 | RB1 FEZF1 ZBTB40 RAD21 YY1 ZNF143 BCLAF1 IKZF2 SP3 HCFC1 | SIGLEC15 LOC105372093 GC18M045733 | |
| GH18I045833 | Enhancer | 0.9 | Ensembl ENCODE | 7.5 | +10.5 | 10523 | 4.7 | CTCF MEIS2 PKNOX1 USF1 SUZ12 MAX SIN3A USF2 REST RAD21 | SIGLEC15 EPG5 GC18P045827 GC18M045898 | |
| GH18I045771 | Enhancer | 0.7 | FANTOM5 ENCODE | 7.3 | -53.6 | -53585 | 1 | ZFHX2 SOX6 | SIGLEC15 SLC14A1 LOC105372093 GC18M045733 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SIGLEC15 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SIGLEC15 Gene
Genomic Locations for SIGLEC15 Gene
- chr18:45,825,512-45,844,080
- (GRCh38/hg38)
- Size:
- 18,569 bases
- Orientation:
- Plus strand
- chr18:43,405,477-43,424,045
- (GRCh37/hg19)
Genomic View for SIGLEC15 Gene
Genes around SIGLEC15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q12.3 by Ensembl
- 18q12.3 by Entrez Gene
- 18q21.1 by HGNC
SIGLEC15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIGLEC15 Gene
Proteins for SIGLEC15 Gene
-
Protein details for SIGLEC15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZMC9-SIG15_HUMAN
- Recommended name:
- Sialic acid-binding Ig-like lectin 15
- Protein Accession:
- Q6ZMC9
- A8K2Y5
- B4DVQ9
Protein attributes for SIGLEC15 Gene
- Size:
- 328 amino acids
- Molecular mass:
- 35653 Da
- Quaternary structure:
-
- Interacts with TYROBP and HCST.
Protein Expression for SIGLEC15 Gene
Post-translational modifications for SIGLEC15 Gene
- Glycosylation at posLast=172172
Other Protein References for SIGLEC15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
- R&D Systems Proteins and Enzymes for SIGLEC15 (Siglec-15)
-
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- antibodies-online: Search results for 2 available SIGLEC15 Proteins ranked by validation data
- Compare Top SIGLEC15 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SIGLEC15
Assay Products
No data available for DME Specific Peptides for SIGLEC15 Gene
Domains & Families for SIGLEC15 Gene
Gene Families for SIGLEC15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for SIGLEC15 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIGLEC15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZMC9UniProtKB/Swiss-Prot:
SIG15_HUMAN :- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
- Family:
-
- Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Function for SIGLEC15 Gene
Molecular function for SIGLEC15 Gene
- UniProtKB/Swiss-Prot Function:
- Binds sialylated glycoproteins.
Phenotypes for SIGLEC15 Gene
- MGI mutant phenotypes for SIGLEC15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SIGLEC15:
Animal Models for SIGLEC15 Gene
- MGI Knock Outs for SIGLEC15:
-
- Siglec15 tm1Yohi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SIGLEC15
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SIGLEC15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SIGLEC15 gene
- Search ViGene Biosciences for SIGLEC15
CRISPR Products
-
OriGene CRISPR knockouts for SIGLEC15
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- Overview of 70 available SIGLEC15 gene related products
- Applied Biological Materials CRISPR for SIGLEC15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC15
- GenScript: Design CRISPR guide RNA sequences for SIGLEC15
miRNA for SIGLEC15 Gene
- miRTarBase miRNAs that target SIGLEC15
miRNA Products
- Search ViGene Biosciences for SIGLEC15
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for SIGLEC15
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- Overview of 70 available SIGLEC15 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SIGLEC15 gene
Clone Products
-
OriGene ORF clones in human for SIGLEC15
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SIGLEC15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SIGLEC15 (Siglec-15)
Cell Line Products
-
Horizon Cell Lines for SIGLEC15
-
ViGene Biosciences adenoviral particle packaged cDNA for SIGLEC15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SIGLEC15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SIGLEC15 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC15 Gene
Localization for SIGLEC15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC15 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043234 | protein complex | IEA | -- |
Pathways & Interactions for SIGLEC15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | RET signaling | ||
Pathways by source for SIGLEC15 Gene
3 Reactome pathways for SIGLEC15 Gene
Interacting Proteins for SIGLEC15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032956 | regulation of actin cytoskeleton organization | IEA | -- |
| GO:0045087 | innate immune response | TAS | -- |
| GO:0045124 | regulation of bone resorption | IEA | -- |
| GO:2001204 | regulation of osteoclast development | IEA | -- |
No data available for SIGNOR curated interactions for SIGLEC15 Gene
Transcripts for SIGLEC15 Gene
mRNA/cDNA for SIGLEC15 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SIGLEC15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SIGLEC15
- genomics-online: gRNA clones - Search results for 70 available SIGLEC15 gene related products
- Overview of 70 available SIGLEC15 gene related products
- Applied Biological Materials CRISPR for SIGLEC15
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIGLEC15
- GenScript: Design CRISPR guide RNA sequences for SIGLEC15
miRNA Products
- Search ViGene Biosciences for SIGLEC15
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for SIGLEC15
- Browse OriGene Inhibitory RNA Products For SIGLEC15
- genomics-online: shRNA clones - Search results for 70 available SIGLEC15 gene related products
- Overview of 70 available SIGLEC15 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SIGLEC15 gene
Clone Products
-
OriGene ORF clones in human for SIGLEC15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIGLEC15
- VectorBuilder custom plasmid, inducible vectors for SIGLEC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIGLEC15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SIGLEC15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SIGLEC15 (Siglec-15)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | - |
Expression for SIGLEC15 Gene
mRNA differential expression in normal tissues according to GTEx for SIGLEC15 Gene
This gene is overexpressed in Bladder (x10.5), Whole Blood (x4.6), and Spleen (x4.2).
This gene is overexpressed in Peripheral blood mononuclear cells (61.9) and Breast (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC15 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SIGLEC15 Gene:
SIGLEC15SOURCE GeneReport for Unigene cluster for SIGLEC15 Gene:
Hs.287692mRNA Expression by UniProt/SwissProt for SIGLEC15 Gene:
Q6ZMC9-SIG15_HUMAN
Tissue specificity:
Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
Evidence on tissue expression from TISSUES for SIGLEC15 Gene
- Blood(4)
- Liver(4)
- Spleen(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for SIGLEC15
-
OriGene qPCR primer pairs for SIGLEC15
- genomics-online: primer clones - Search results for 70 available SIGLEC15 gene related products
- Overview of 70 available SIGLEC15 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC15 Gene
Orthologs for SIGLEC15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SIGLEC15 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SIGLEC15 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Siglec15 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Siglec15 33 |
|
||
| dog (Canis familiaris) |
Mammalia | SIGLEC15 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SIGLEC15 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SIGLEC15 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SIGLEC15 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | siglec15 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-11p23.7 33 |
|
||
| SIGLEC15 34 |
|
OneToOne |
- Species where no ortholog for SIGLEC15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SIGLEC15 Gene
No data available for Paralogs for SIGLEC15 Gene
Variants for SIGLEC15 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000135281 | -- | 45,829,618(+) | CCCCC/CCCCCC | intron_variant | |
| rs1000146526 | -- | 45,828,474(+) | G/A | intron_variant | |
| rs1000192772 | -- | 45,841,457(+) | G/C | intron_variant | |
| rs1000679785 | -- | 45,834,381(+) | C/T | intron_variant | |
| rs1000846482 | -- | 45,833,184(+) | T/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv613e214 | CNV | gain | 21293372 |
| esv3642417 | CNV | loss | 21293372 |
| esv3893100 | CNV | gain | 25118596 |
| nsv525268 | CNV | gain | 19592680 |
Gene Damage Index Score:
9.70;
89.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIGLEC15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIGLEC15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC15 Gene
Disorders for SIGLEC15 Gene
Additional Disease Information for SIGLEC15
No disorders were found for SIGLEC15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC15 Gene
Publications for SIGLEC15 Gene
- Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PMID: 17483134) Angata T … Nakamura M (Glycobiology 2007) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
- The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. (PMID: 23035012) Takamiya R … Angata T (Glycobiology 2013) 3 58
- DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4 58
Products for SIGLEC15 Gene
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- Invitrogen Antibodies for SIGLEC15
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- VectorBuilder custom plasmid, inducible vectors for SIGLEC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SIGLEC15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 29 available SIGLEC15 Antibodies ranked by validation data
- Compare Top SIGLEC15 Antibodies
- antibodies-online: Search results for available SIGLEC15 related products ranked by validation data
- antibodies-online: Search results for 2 available SIGLEC15 Proteins ranked by validation data
- Compare Top SIGLEC15 Proteins
- Quality Products:
- Search GeneTex for Antibodies for SIGLEC15
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- ViGene Biosciences adenoviral particle packaged cDNA for SIGLEC15 gene
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- Custom Antibody ServicesProSci Antibodies for SIGLEC15
- Search for SIGLEC15 Proteins at ProSci
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- genomics-online: cdna clones - Search results for 70 available SIGLEC15 gene related products
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- Overview of 70 available SIGLEC15 gene related products
- genomics-online: shRNA clones - Search results for 70 available SIGLEC15 gene related products
- Overview of 70 available SIGLEC15 gene related products
Sources for SIGLEC15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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