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SIGLEC15 Gene

protein-coding   GIFtS: 47
GCID: GC18P043405

Sialic Acid Binding Ig-Like Lectin 15

(Previous names: CD33 antigen-like 3, CD33 molecule-like 3)
(Previous symbol: CD33L3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 151 2     HsT13612
CD33L31 2 3     SIGLEC-152
CD33 Antigen-Like 31 2 3     Sialic Acid-Binding Ig-Like Lectin 152
CD33 Molecule-Like 31 2     Siglec-153

External Ids:    HGNC: 275961   Entrez Gene: 2842662   Ensembl: ENSG000001970467   UniProtKB: Q6ZMC93   

Export aliases for SIGLEC15 gene to outside databases

Previous GC identifers: GC18P041660 GC18P040262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC15 Gene:
SIGLEC15 (sialic acid binding Ig-like lectin 15) is a protein-coding gene. Diseases associated with SIGLEC15 include giant cell tumor.

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9
Function: Binds sialylated glycoproteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC15 gene promoter:
         AML1a   HSF2   ARP-1   HSF1short   HSF1 (long)   ATF6   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC15 promoter sequence
   Search Chromatin IP Primers for SIGLEC15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q21.1

SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC15 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043405:  view genomic region     (about GC identifiers)

Start:
43,405,477 bp from pter      End:
43,424,045 bp from pter
Size:
18,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 15 precursor  
Size: 328 amino acids; 35653 Da
Subunit: Interacts with TYROBP and HCST
Secondary accessions: A8K2Y5

Explore the universe of human proteins at neXtProt for SIGLEC15: NX_Q6ZMC9

Explore proteomics data for SIGLEC15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn172
  • Modification sites at PhosphoSitePlus

  • See SIGLEC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_998767.1  
    ENSEMBL proteins: 
     ENSP00000374125   ENSP00000443509   ENSP00000466774  
    Reactome Protein details: Q6ZMC9

    SIGLEC15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for SIGLEC15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6ZMC9

    ProtoNet protein and cluster: Q6ZMC9

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIGLEC15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIG15_HUMAN, Q6ZMC9
    Function: Binds sialylated glycoproteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SIGLEC15 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Siglec15):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 
     skeleton 

    SIGLEC15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIGLEC15
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SIGLEC15:
    hsa-miR-2114*
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC15 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIG15_HUMAN, Q6ZMC9: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0043234protein complex IEA--

    SIGLEC15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIGLEC15 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 interactions0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SIGLEC15
        DAP12 interactions



    SIGLEC15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC15
    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SIGLEC15 (ENSP000003741254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000268500ENSP000004152004STRING: ENSP00000415200
    TYROBPENSP000002626294STRING: ENSP00000262629
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032956regulation of actin cytoskeleton organization IEA--
    GO:0045087innate immune response TAS--
    GO:0045124regulation of bone resorption IEA--
    GO:0071402cellular response to lipoprotein particle stimulus IEA--
    GO:2001204regulation of osteoclast development IEA--

    SIGLEC15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC15 (SIG15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIGLEC15 gene: 
    NM_213602.2  

    Unigene Cluster for SIGLEC15:

    Sialic acid binding Ig-like lectin 15
    Hs.287692  [show with all ESTs]
    Unigene Representative Sequence: AK095432
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389474(uc002lbl.1 uc010xcp.1) ENST00000602118 ENST00000546268
    ENST00000587418 ENST00000593178
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIGLEC15 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SIGLEC15:
    hsa-miR-2114*
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC15 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SIGLEC15
    Predesigned siRNA for gene silencing in human, mouse, rat SIGLEC15
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIGLEC15
      QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC15
      QuantiFast Probe-based Assays in human, mouse, rat SIGLEC15

    Additional mRNA sequence: 

    AK025833.1 AK092746.1 AK095432.1 AK172835.1 AK290400.1 AK290402.1 AK301189.1 AY971516.1 

    4 DOTS entries:

    DT.99981522  DT.97815880  DT.97824933  DT.100011128 

    17 AceView cDNA sequences:

    AK172835 AK095432 AI568147 NM_213602 BU174116 AK092746 AK025833 AX747704 
    BV194831 BQ773037 BM808284 BM423379 BU621715 AW769853 BU634236 BM916833 
    BE062674 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -                                 
    SP2:              -                                 
    SP3:                          -     -               


    ECgene alternative splicing isoforms for SIGLEC15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTGGGA
    SIGLEC15 Expression
    About this image

    SIGLEC15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287692

    UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9
    Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIGLEC15 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglec151 , 5 sialic acid binding Ig-like lectin 151, 5 85.65(n)1
    84.18(a)1
      18 (52.43 cM)5
    6202351  NM_001101038.11  NP_001094508.11 
     780436145 
    chicken
    (Gallus gallus)
    Aves SIGLEC151 sialic acid binding Ig-like lectin 15 57.96(n)
    51.33(a)
      770432  XM_001233765.2  XP_001233766.2 
    lizard
    (Anolis carolinensis)
    Reptilia SIGLEC156
    sialic acid binding Ig-like lectin 15
    54(a)
    1 ↔ 1
    1(35256505-35258392)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia siglec151 sialic acid binding Ig-like lectin 15 53.54(n)
    45(a)
      100487460  XM_002936510.2  XP_002936556.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-11p23.71 si:dkey-11p23.7 50.52(n)
    39.11(a)
      100006927  NM_001102395.1  NP_001095865.1 


    ENSEMBL Gene Tree for SIGLEC15 (if available)
    TreeFam Gene Tree for SIGLEC15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC15 (see all 394)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800809571,2
    C,F--43403650(+) AAAGTC/TCTGTG 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1918190241,2
    C--43403701(+) CCCAGA/GAAAAG 1 -- us2k10--------
    rs1828919251,2
    --43403858(+) GTGGCA/GCTCTA 1 -- us2k10--------
    rs1857485971,2
    --43403909(+) ACCTTA/GTATCT 1 -- us2k10--------
    rs99645921,2
    C,F,A,H--43403930(+) AGGAAT/CGATAA 1 -- us2k1 tfbs35Minor allele frequency- C:0.05NS EA WA 536
    rs1472849191,2
    --43403952(+) AATAAA/GTACAT 1 -- us2k10--------
    rs1396806021,2
    C--43404120(+) CAGCCC/TCTGGG 1 -- us2k10--------
    rs615434751,2
    --43404180(+) TTTTTA/TTTTTT 1 -- us2k10--------
    rs1493595591,2
    --43404195(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1826428331,2
    --43404306(+) AGCTGA/GGACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIGLEC15 (43405477 - 43424045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SIGLEC15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525268CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC15
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SIGLEC15:    
    About MalaCards
    giant cell tumor


    SIGLEC15 for disorders           About GeneDecksing


    Export disorders for SIGLEC15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC15 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SIGLEC15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PubMed id 17483134)1, 2, 3 Angata T.... Nakamura M. (Glycobiology 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-I^ secretion from monocytes/macrophages through the DAP12-Syk pathway. (PubMed id 23035012)1 Takamiya R....Angata T. (Glycobiology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284266 HGNC: 27596 AceView: CD33L3 Ensembl:ENSG00000197046 euGenes: HUgn284266
    ECgene: SIGLEC15 H-InvDB: SIGLEC15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC15 gene:
    Search GeneIP for patents involving SIGLEC15

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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