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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIGLEC15 Gene

protein-coding GIFtS: 46
GCID: GC18P043405

Sialic Acid Binding Ig-Like Lectin 15

(Previous names: CD33 antigen-like 3, CD33 molecule-like 3)
(Previous symbol: CD33L3)

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Sialic Acid Binding Ig-Like Lectin 15¹ ²		HsT1361²
CD33L3¹ ² ³		SIGLEC-15²
CD33 Antigen-Like 3¹ ² ³		Sialic Acid-Binding Ig-Like Lectin 15²
CD33 Molecule-Like 3¹ ²		Siglec-15³

External Ids:	HGNC: 27596¹	Entrez Gene: 284266²	Ensembl: ENSG00000197046⁷	UniProtKB: Q6ZMC9³

Export aliases for SIGLEC15 gene to outside databases

Previous GC identifers: GC18P041660 GC18P040262

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIGLEC15 Gene:

SIGLEC15 (sialic acid binding Ig-like lectin 15) is a protein-coding gene. Diseases associated with SIGLEC15 include giant cell tumor, and among its related super-pathways are Immune System and DAP12 signaling.

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Function: Binds sialylated glycoproteins

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NT_010966.14 NC_018929.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIGLEC15 gene promoter:
AML1a HSF2 ARP-1 HSF1short HSF1 (long) ATF6 c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIGLEC15 promoter sequence

Search SABiosciences Chromatin IP Primers for SIGLEC15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3 Ensembl cytogenetic band: 18q12.3 HGNC cytogenetic band: 18q21.1

SIGLEC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC15 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P043405: view genomic region (about GC identifiers)

Start:	43,405,477 bp from pter	End:	43,424,045 bp from pter
Size:	18,569 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9 (See protein sequence)

Recommended Name: Sialic acid-binding Ig-like lectin 15 precursor

Size: 328 amino acids; 35653 Da

Subunit: Interacts with TYROBP and HCST

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: A8K2Y5

Explore the universe of human proteins at neXtProt for SIGLEC15: NX_Q6ZMC9

Explore proteomics data for SIGLEC15 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6ZMC9

SIGLEC15 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_998767.1

ENSEMBL proteins:

ENSP00000374125 ENSP00000443509 ENSP00000466774

Reactome Protein details: Q6ZMC9
Human Recombinant Protein Products for SIGLEC15:

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0043234	protein complex	IEA	--

SIGLEC15 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

SIGLEC: Sialic acid binding Ig-like lectins

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q6ZMC9

ProtoNet protein and cluster: Q6ZMC9

1 Blocks protein domain: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

SIGLEC15 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SIG15_HUMAN, Q6ZMC9

Function: Binds sialylated glycoproteins

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

SIGLEC15 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Siglec15):

cellular	hematopoietic system	homeostasis/metabolism	immune system	renal/urinary system
skeleton

SIGLEC15 for phenotypes About GeneDecksing

Animal Models:

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		hsa-miR-2114*
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SIGLEC15 About

See pathways by source

SuperPath

Contained pathways About

Immune System

Immune System

0.56

Innate Immune System

0.50

Signaling by FGFR

DAP12 interactions

0.91

Pathways by source See SuperPaths
Show all pathways

3 Reactome Pathways for SIGLEC15

	DAP12 interactions
	Immune System
	Innate Immune System

SIGLEC15 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SIGLEC15

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SIGLEC15 (ENSP00000374125⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000268500	ENSP00000415200⁴	STRING: ENSP00000415200
TYROBP	ENSP00000262629⁴	STRING: ENSP00000262629

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032956	regulation of actin cytoskeleton organization	IEA	--
GO:0045087	innate immune response	TAS	--
GO:0045124	regulation of bone resorption	IEA	--
GO:0071402	cellular response to lipoprotein particle stimulus	IEA	--
GO:2001204	regulation of osteoclast development	IEA	--

SIGLEC15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIGLEC15 (SIG15)

Search CenterWatch for drugs/clinical trials and news about SIGLEC15 / SIG15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIGLEC15 gene:

NM_213602.2

Unigene Cluster for SIGLEC15:

Sialic acid binding Ig-like lectin 15

Hs.287692 [show with all ESTs]

Unigene Representative Sequence: AK095432

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389474(uc002lbl.1 uc010xcp.1) ENST00000602118 ENST00000546268

ENST00000587418 ENST00000593178

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Additional mRNA sequence:

AK025833.1 AK092746.1 AK095432.1 AK172835.1 AK290400.1 AK290402.1 AK301189.1 AY971516.1

4 DOTS entries:

DT.99981522 DT.97815880 DT.97824933 DT.100011128

17 AceView cDNA sequences:

AK025833 BU174116 AK172835 NM_213602 AK095432 AK092746 AX747704 AI568147

BM808284 BV194831 BU621715 BU634236 BM423379 BQ773037 AW769853 BM916833

BE062674

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC15 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:					-
SP2:					-
SP3:									-		-

ECgene alternative splicing isoforms for SIGLEC15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIGLEC15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCCCCTGGGA

About this image

See SIGLEC15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIGLEC15

SOURCE GeneReport for Unigene cluster: Hs.287692

UniProtKB/Swiss-Prot: SIG15_HUMAN, Q6ZMC9

Tissue specificity: Expressed in macrophage and/or dendritic cells of spleen and lymph nodes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC15 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Siglec15^{1 , 5}	sialic acid binding Ig-like lectin 15^{1, 5}	85.65(n)¹ 84.18(a)¹		18 (52.43 cM)⁵ 620235¹ NM_001101038.1¹ NP_001094508.1¹ 78043614⁵
chicken (Gallus gallus)	Aves	SIGLEC15¹	sialic acid binding Ig-like lectin 15	57.2(n) 50.21(a)		770432 XM_001233765.2 XP_001233766.2
lizard (Anolis carolinensis)	Reptilia	SIGLEC15⁶	Uncharacterized protein	53(a)	1 ↔ 1	1(35256505-35258392)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-11p23.7¹	si:dkey-11p23.7	50.56(n) 39.92(a)		100006927 NM_001102395.1 NP_001095865.1

ENSEMBL Gene Tree for SIGLEC15 (if available)
TreeFam Gene Tree for SIGLEC15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80080957^1,2	C,F	--	43403650(+)	`AAAGTC/TCTGTG`	1	--	us2k¹		1		EA	120
rs191819024^1,2	C	--	43403701(+)	`CCCAGA/GAAAAG`	1	--	us2k¹		0	--	--	--	--
rs182891925^1,2		--	43403858(+)	`GTGGCA/GCTCTA`	1	--	us2k¹		0	--	--	--	--
rs185748597^1,2		--	43403909(+)	`ACCTTA/GTATCT`	1	--	us2k¹		0	--	--	--	--
rs9964592^1,2	C,F,A,H	--	43403930(+)	`AGGAAT/CGATAA`	1	--	us2k¹ tfbs³		5		NS EA WA	536
rs147284919^1,2		--	43403952(+)	`AATAAA/GTACAT`	1	--	us2k¹		0	--	--	--	--
rs139680602^1,2	C	--	43404120(+)	`CAGCCC/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs61543475^1,2		--	43404180(+)	`TTTTTA/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs149359559^1,2		--	43404195(+)	`GAGACA/GGAGTC`	1	--	us2k¹		0	--	--	--	--
rs182642833^1,2		--	43404306(+)	`AGCTGA/GGACTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIGLEC15 (43405477 - 43424045 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for SIGLEC15: About this table

Variant ID	Type	Subtype	PubMed ID
nsv525268	CNV	Gain	19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for SIGLEC15: About MalaCards

giant cell tumor

SIGLEC15 for disorders About GeneDecksing

Export disorders for SIGLEC15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SIGLEC15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIGLEC15)

Utopia: connect your pdf to the dynamic
world of online information

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. (PubMed id 17483134)^{1, 2, 3} Angata T.... Nakamura M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-b secretion from monocytes/macrophages through t he DAP12-Syk pathway. (PubMed id 23035012)¹ Takamiya R....Angata T. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284266	HGNC: 27596	AceView: CD33L3	Ensembl:ENSG00000197046	euGenes: HUgn284266
ECgene: SIGLEC15	H-InvDB: SIGLEC15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIGLEC15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIGLEC15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SIGLEC15 gene:
Search GeneIP for patents involving SIGLEC15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SIGLEC15 gene at Home site.

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SIGLEC15 Gene

Sialic Acid Binding Ig-Like Lectin 15

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SIGLEC15 Gene

Sialic Acid Binding Ig-Like Lectin 15

Aliasesfor SIGLEC15 gene

Summariesfor SIGLEC15 gene

Genomic Viewsfor SIGLEC15 gene

Proteinsfor SIGLEC15 gene

Protein Domains /Familiesfor SIGLEC15 gene

Functionfor SIGLEC15 gene

Pathways & Interactionsfor SIGLEC15 gene

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Transcriptsfor SIGLEC15 gene

Expression for SIGLEC15 gene

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Genome Databases showing SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene

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for SIGLEC15 gene

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