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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGLEC14 Gene

protein-coding   GIFtS: 39
GCID: GC19M052145

Sialic Acid Binding Ig-Like Lectin 14

  Search for SIGLEC14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sialic Acid Binding Ig-Like Lectin 141 2
Sialic Acid-Binding Ig-Like Lectin 142
siglec-142
Siglec-143

External Ids:    HGNC: 329261   Entrez Gene: 1000495872   Ensembl: ENSG000002544157   UniProtKB: Q08ET23   

Export aliases for SIGLEC14 gene to outside databases

Previous GC identifers: GC19U900740 GC19M056837 GC19M052115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIGLEC14 Gene: 
SIGLEC14 (sialic acid binding Ig-like lectin 14) is a protein-coding gene. Among its related super-pathways are Immune System and DAP12 signaling. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGLEC14 gene promoter:
         PPAR-gamma1   GATA-3   POU2F1   POU2F1a   FOXO4   ARP-1   PPAR-gamma2   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SIGLEC14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052145:  view genomic region     (about GC identifiers)

Start:
52,145,806 bp from pter      End:
52,150,132 bp from pter
Size:
4,327 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 14 precursor  
Size: 396 amino acids; 43970 Da
Subunit: Interacts with TYROBP
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q6UXG0

Explore the universe of human proteins at neXtProt for SIGLEC14: NX_Q08ET2

Explore proteomics data for SIGLEC14 at MOPED 

SIGLEC14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SIGLEC14 Protein Expression

REFSEQ proteins: NP_001092082.1  
ENSEMBL proteins: 
 ENSP00000354090  
Reactome Protein details: Q08ET2
Human Recombinant Protein Products for SIGLEC14: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

SIGLEC14 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
SIGLEC: Sialic acid binding Ig-like lectins
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
VSET: Immunoglobulin superfamily / V-set domain containing

5/7 InterPro protein domains (see all 7):
 IPR003598 Ig_sub2
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q08ET2

ProtoNet protein and cluster: Q08ET2

1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


SIGLEC14 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SIG14_HUMAN, Q08ET2
Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
SIGLEC14 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SIGLEC14 About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune System
Immune System0.56
Innate Immune System0.50
2Signaling by FGFR
DAP12 interactions0.91

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


3        Reactome Pathways for SIGLEC14
    DAP12 interactions
Immune System
Innate Immune System



SIGLEC14 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC14

1 Interacting protein for SIGLEC14 (Q08ET23) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TYROBPO439143I2D: score=2 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--
GO:0045087innate immune response TAS--

SIGLEC14 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIGLEC14 (SIG14)

Search CenterWatch for drugs/clinical trials and news about SIGLEC14 / SIG14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIGLEC14 gene: 
NM_001098612.1  

Unigene Cluster for SIGLEC14:

Sialic acid binding Ig-like lectin 14
Hs.707374  [show with all ESTs]
Unigene Representative Sequence: NM_001098612
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360844(uc002pxf.4) ENST00000533866
miRNA
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Additional mRNA sequence: 

AK298284.1 AY854038.1 

3 DOTS entries:

DT.91718767  DT.121433286  DT.207335 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIGLEC14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGGACATCA
SIGLEC14 Expression
About this image


See SIGLEC14 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.707374

UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also
detected in lung and testis

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC14

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC14 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
--
62(a)
26(a)
many ↔ many
many ↔ many
1(105445019-105460545)
1(105461204-105462282)


ENSEMBL Gene Tree for SIGLEC14 (if available)
TreeFam Gene Tree for SIGLEC14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SIGLEC14 gene
CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC122  MAG2  
SIGLEC102  SIGLEC72  SIGLEC92  
11 SIMAP similar genes for SIGLEC14 using alignment to 1 protein entry:     SIG14_HUMAN:
SIGLEC5    CD33    SIGLEC6    SIGLEC9    SIGLEC12    SIGLEC7
CEA    SIGLEC11    SIGLEC10    SIGLEC16    SIGLEC8

SIGLEC14 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SIGLEC14
PGOHUM00000234382


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/142 SNPs in SIGLEC14 are shown (see all 142)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs556821601,2
C,F--52145322(+) ACTTCT/CAAGCA 1 -- ds50012Minor allele frequency- C:0.09NA 122
rs621068811,2
C,F--52145331(+) CAATCC/TGTGAA 1 -- ds50014Minor allele frequency- T:0.22NA WA 242
rs1438375381,2
--52145357(+) AGGGGA/GAAGAA 1 -- ds50010--------
rs786590431,2
C--52145446(+) CAGAAC/TCAGTG 1 -- ds50013Minor allele frequency- T:0.09NA WA 240
rs104059901,2
C,F,A,H--52145524(+) tgataC/Tgtgta 1 -- ds50014Minor allele frequency- T:0.03NS CSA WA 340
rs1823429851,2
--52145525(+) GATACA/GTGTAA 1 -- ds50010--------
rs341973731,2
C,F--52145535(+) ACAACG/ATGGAT 1 -- ds50017Minor allele frequency- A:0.22NA CSA WA EA 366
rs359919971,2
C--52145758(+) AAAAAA/-GACAT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
rs1468529351,2
--52145918(+) CAAATG/TCTGCC 1 -- ut310--------
rs1406508381,2
--52145982(+) AGAAGA/GTAACT 1 -- ut310--------

HapMap Linkage Disequilibrium report for SIGLEC14 (52145806 - 52150132 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/24 variations for SIGLEC14 (see all 24):    About this table     
Variant IDTypeSubtypePubMed ID
dgv656e199CNV Deletion23128226
esv2516533CNV Deletion19546169
nsv2532CNV Loss18451855
dgv593n67CNV Loss20364138
esv27396CNV Loss19812545
dgv595n67CNV Loss20364138
nsv458725CNV Loss19166990
dgv30n47CNV Loss21111241
nsv828612CNV Loss20364138
nsv828611CNV Loss20364138


Human Gene Mutation Database (HGMD): SIGLEC14
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIGLEC14 for disorders           About MalaCards

SIGLEC14 for disorders           About GeneDecksing


Export disorders for SIGLEC14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SIGLEC14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIGLEC14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PubMed id 17012248)1, 2, 3 Angata T.... Nakamura M. (2006)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  3. Deletion polymorphism of SIGLEC14 and its functional implications. (PubMed id 19369701)1 Yamanaka M....Narimatsu H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100049587 HGNC: 32926 Ensembl:ENSG00000254415 euGenes: HUgn100049587 ECgene: SIGLEC14
H-InvDB: SIGLEC14

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SIGLEC14 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SIGLEC14 gene:
Search GeneIP for patents involving SIGLEC14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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