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Aliases for SIGLEC14 Gene

Aliases for SIGLEC14 Gene

  • Sialic Acid Binding Ig-Like Lectin 14 2 3
  • Siglec-14 3 4
  • Sialic Acid-Binding Ig-Like Lectin 14 3

External Ids for SIGLEC14 Gene

Previous GeneCards Identifiers for SIGLEC14 Gene

  • GC19U900740
  • GC19M056837
  • GC19M052115
  • GC19M052145

Summaries for SIGLEC14 Gene

GeneCards Summary for SIGLEC14 Gene

SIGLEC14 (Sialic Acid Binding Ig-Like Lectin 14) is a Protein Coding gene. Among its related pathways are Signaling by FGFR. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC14 Gene

  • Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC14 Gene

Genomics for SIGLEC14 Gene

Regulatory Elements for SIGLEC14 Gene

Genomic Location for SIGLEC14 Gene

51,642,553 bp from pter
51,646,879 bp from pter
4,327 bases
Minus strand

Genomic View for SIGLEC14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC14 Gene

Proteins for SIGLEC14 Gene

  • Protein details for SIGLEC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialic acid-binding Ig-like lectin 14
    Protein Accession:
    Secondary Accessions:
    • Q6UXG0

    Protein attributes for SIGLEC14 Gene

    396 amino acids
    Molecular mass:
    43970 Da
    Quaternary structure:
    • Interacts with TYROBP.

neXtProt entry for SIGLEC14 Gene

Proteomics data for SIGLEC14 Gene at MOPED

Post-translational modifications for SIGLEC14 Gene

Other Protein References for SIGLEC14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SIGLEC14 Gene

Domains for SIGLEC14 Gene

Gene Families for SIGLEC14 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SIGLEC14 Gene

Suggested Antigen Peptide Sequences for SIGLEC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q08ET2
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC14: view

Function for SIGLEC14 Gene

Molecular function for SIGLEC14 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors.

Gene Ontology (GO) - Molecular Function for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGLEC14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIGLEC14 Gene

Localization for SIGLEC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SIGLEC14 Gene COMPARTMENTS Subcellular localization image for SIGLEC14 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC14: view

Pathways for SIGLEC14 Gene

SuperPathways for SIGLEC14 Gene

Superpath Contained pathways
1 Signaling by FGFR
genes like me logo Genes that share pathways with SIGLEC14: view

Pathways by source for SIGLEC14 Gene

1 Reactome pathway for SIGLEC14 Gene

Gene Ontology (GO) - Biological Process for SIGLEC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with SIGLEC14: view

Transcripts for SIGLEC14 Gene

mRNA/cDNA for SIGLEC14 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC14 Gene

Sialic acid binding Ig-like lectin 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGLEC14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC14 Gene

No ASD Table

Relevant External Links for SIGLEC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIGLEC14 Gene

mRNA expression in normal human tissues for SIGLEC14 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC14 Gene

This gene is overexpressed in Whole Blood (32.2) and Spleen (6.3).

Protein differential expression in normal tissues for SIGLEC14 Gene

This gene is overexpressed in Serum (33.3), Cervix (17.9), and Cerebrospinal fluid (15.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC14 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC14 Gene Hs.707374

mRNA Expression by UniProt/SwissProt for SIGLEC14 Gene

Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis.
genes like me logo Genes that share expressions with SIGLEC14: view

Expression partners for SIGLEC14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC14 Gene

Orthologs for SIGLEC14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC512863 35
  • 77.17 (n)
  • 65.76 (a)
-- 36
  • 39 (a)
-- 36
  • 58 (a)
-- 36
  • 56 (a)
(Pan troglodytes)
Mammalia SIGLEC5 35
  • 98.7 (n)
  • 96.63 (a)
-- 36
  • 31 (a)
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
-- 36
  • 29 (a)
Species with no ortholog for SIGLEC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC14 Gene

Gene Tree for SIGLEC14 (if available)
Gene Tree for SIGLEC14 (if available)

Paralogs for SIGLEC14 Gene

Paralogs for SIGLEC14 Gene

Selected SIMAP similar genes for SIGLEC14 Gene using alignment to 1 proteins: Pseudogenes for SIGLEC14 Gene

genes like me logo Genes that share paralogs with SIGLEC14: view

Variants for SIGLEC14 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs883551 -- 51,647,264(-) CCCTG(A/G)CAACT upstream-variant-2KB
rs883552 -- 51,646,939(+) GAGGC(G/T)GGGGC upstream-variant-2KB
rs883688 -- 51,646,246(-) GCAGG(A/G)ACCCT intron-variant
rs885266 -- 51,645,551(-) GCTGG(G/T)GCTGT intron-variant
rs1868951 -- 51,644,546(+) GGGAT(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC14 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
nsv469584 CNV Complex 16826518
dgv1110e1 CNV Complex 17122850
nsv510771 CNV Loss 20534489
nsv2532 CNV Loss 18451855
nsv181 CNV Loss 15895083
nsv912295 CNV Gain 21882294
nsv458725 CNV Loss 19166990
dgv593n67 CNV Loss 20364138
esv27396 CNV Loss 19812545
dgv656e199 CNV Deletion 23128226
nsv9741 CNV Loss 18304495
esv2516533 CNV Deletion 19546169
dgv30n47 CNV Loss 21111241
esv32724 CNV Gain 17666407
esv2571166 CNV Loss 19546169
dgv594n67 CNV Loss 20364138
dgv4e195 OTHER Complex 20811451
nsv442771 CNV CNV 18776908
dgv1111e1 CNV Complex 17122850
dgv595n67 CNV Loss 20364138
nsv828611 CNV Loss 20364138
nsv828612 CNV Loss 20364138

Relevant External Links for SIGLEC14 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC14 Gene

Disorders for SIGLEC14 Gene

No disorders were found for SIGLEC14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SIGLEC14 Gene

Publications for SIGLEC14 Gene

  1. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T. … Nakamura M. (FASEB J. 2006) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Deletion polymorphism of SIGLEC14 and its functional implications. (PMID: 19369701) Yamanaka M. … Narimatsu H. (Glycobiology 2009) 3
  4. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. (PMID: 23519826) Angata T. … Taniguchi N. (Cell. Mol. Life Sci. 2013) 3
  5. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. (PMID: 24799499) Ali S.R. … Varki A. (J. Exp. Med. 2014) 3

Products for SIGLEC14 Gene

Sources for SIGLEC14 Gene

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