SIGLEC14 Gene
protein-coding GIFtS: 40
GCID: GC19M052145
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sialic acid binding Ig-like lectin 14
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Aliases
for SIGLEC14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sialic Acid Binding Ig-Like Lectin 141 2 | | Sialic Acid-Binding Ig-Like Lectin 142 | | Siglec-143 | | Siglec-143 |
Export aliases for SIGLEC14 gene to outside databasesPrevious GC identifers: GC19U900740 GC19M056837 GC19M052115 |
Summaries
for SIGLEC14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors
|
Genomic Views
for SIGLEC14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIGLEC14 gene promoter:
PPAR-gamma1 GATA-3 POU2F1 POU2F1a FOXO4 ARP-1 PPAR-gamma2 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIGLEC14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41SIGLEC14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M052145: view genomic region
(about GC identifiers)
Start:
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52,145,806 bp from pter |
End:
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52,150,132 bp from pter |
Size:
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4,327 bases |
Orientation:
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minus strand |
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Proteins
for SIGLEC14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2 (See
protein sequence)Recommended Name: Sialic acid-binding Ig-like lectin 14 precursor Size: 396 amino acids; 43970 Da
Subunit: Interacts with TYROBP
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q6UXG0Explore the universe of human proteins at neXtProt for SIGLEC14: NX_Q08ET2
SIGLEC14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092082.1
ENSEMBL proteins: ENSP00000354090 Reactome Protein details: Q08ET2
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SIGLEC14 for ontologies About GeneDecksing
SIGLEC14 Antibody Products:
Assay Products for SIGLEC14: |
Protein
Domains /
Families
for SIGLEC14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIGLEC14 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q08ET2ProtoNet protein and cluster: Q08ET2 1 Blocks protein family: IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIGLEC14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SIGLEC14 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC14 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
-- | -- |
SIGLEC14 for ontologies About GeneDecksing
|
Pathways & Interactions
for SIGLEC14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for SIGLEC14
SIGLEC14 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC14
1 Interacting protein for SIGLEC14 (Q08ET23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
SIGLEC14 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIGLEC14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIGLEC14
Search CenterWatch for drugs/clinical trials and news about SIGLEC14 / SIG14
|
Transcripts
for SIGLEC14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIGLEC14 gene: NM_001098612.1 Unigene Cluster for SIGLEC14: Sialic acid binding Ig-like lectin 14 Hs.707374 [show with all ESTs]Unigene Representative Sequence: NM_0010986122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360844(uc002pxf.4) ENST00000533866
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIGLEC14 (NM_001098612) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC14 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC14 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC14 |
Additional cDNA sequence: AK298284.1 AY854038.1 3 DOTS entries: DT.91718767 DT.121433286 DT.207335
GeneLoc Exon Structure
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Expression
for SIGLEC14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIGLEC14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGACATCA
About this image
See SIGLEC14 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.707374
UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Alsodetected in lung and testis
SABiosciences Custom PCR Arrays for SIGLEC14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIGLEC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC14 |
Orthologs
for SIGLEC14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIGLEC14 gene from 2/5 species (see all 5) About this table
Species with no ortholog for SIGLEC14
ENSEMBL Gene Tree for SIGLEC14 (if available)
TreeFam Gene Tree for SIGLEC14 (if available) |
Paralogs
for SIGLEC14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIGLEC14 gene
- CD332 SIGLEC17P2 SIGLEC82 SIGLEC52 SIGLEC162 SIGLEC112 SIGLEC62 SIGLEC122
- MAG2 SIGLEC102 SIGLEC72 SIGLEC92
11 SIMAP similar genes for SIGLEC14 using alignment to 1 protein entry: SIG14_HUMAN:SIGLEC5 CD33 SIGLEC6 SIGLEC9 SIGLEC12 SIGLEC7
CEA SIGLEC11 SIGLEC10 SIGLEC16 SIGLEC8
SIGLEC14 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIGLEC14
PGOHUM00000234382
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Genomic Variants
for SIGLEC14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIGLEC14 (52145806 - 52150132 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for SIGLEC14
15/17 CNVs (see all 17): 89298 78252 32263 35670 67591 3194 7215 35671 38844 78250 37516 89297 4085 102863 89296
Human Gene Mutation Database (HGMD): SIGLEC14
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SIGLEC14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIGLEC14 for disorders About GeneDecksing
1  disease for SIGLEC14: About MalaCardspneumonia
Export disorders for SIGLEC14 gene to outside databases
|
Publications
for SIGLEC14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIGLEC14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIGLEC14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PubMed id 17012248)1, 2, 3 Angata T.... Nakamura M. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Deletion polymorphism of SIGLEC14 and its functional implications. (PubMed id 19369701)1 Yamanaka M....Narimatsu H. (2009)
|
External Searches for SIGLEC14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SIGLEC14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIGLEC14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIGLEC14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIGLEC14 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SIGLEC14 gene:
Search GeneIP for patents involving SIGLEC14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIGLEC14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC14 | | | OriGene Protein Over-expression Lysate for SIGLEC14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIGLEC14 | | OriGene 3'-UTR Clone for SIGLEC14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIGLEC14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC14 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC14 |
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 | | | SIGLEC14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC14 |
|  |  |  | | | | Search ThermoFisher Antibodies for SIGLEC14 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC14 |
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