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SIGLEC14 Gene

protein-coding   GIFtS: 37
GCID: GC19M052145

Sialic Acid Binding Ig-Like Lectin 14

  Search for SIGLEC14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 141 2
Sialic Acid-Binding Ig-Like Lectin 142
siglec-142
Siglec-143

External Ids:    HGNC: 329261   Entrez Gene: 1000495872   Ensembl: ENSG000002544157   UniProtKB: Q08ET23   

Export aliases for SIGLEC14 gene to outside databases

Previous GC identifers: GC19U900740 GC19M056837 GC19M052115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIGLEC14 Gene:
SIGLEC14 (sialic acid binding Ig-like lectin 14) is a protein-coding gene. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC14 gene promoter:
         PPAR-gamma1   GATA-3   POU2F1   POU2F1a   FOXO4   ARP-1   PPAR-gamma2   Arnt   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SIGLEC14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC14 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M052145:  view genomic region     (about GC identifiers)

Start:
52,145,806 bp from pter      End:
52,150,132 bp from pter
Size:
4,327 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 14 precursor  
Size: 396 amino acids; 43970 Da
Subunit: Interacts with TYROBP
Secondary accessions: Q6UXG0

Explore the universe of human proteins at neXtProt for SIGLEC14: NX_Q08ET2

Explore proteomics data for SIGLEC14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn231

  • See SIGLEC14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092082.1  
    ENSEMBL proteins: 
     ENSP00000354090  
    Reactome Protein details: Q08ET2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry Q08ET2

    ProtoNet protein and cluster: Q08ET2

    1 Blocks protein domain: IPB003598 Immunoglobulin C-2 type

    UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIGLEC14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIG14_HUMAN, Q08ET2
    Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SIGLEC14 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIG14_HUMAN, Q08ET2: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    endosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SIGLEC14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIGLEC14 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    DAP12 interactions0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SIGLEC14
        DAP12 interactions



    SIGLEC14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC14
    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC14

    1 Interacting protein for SIGLEC14 (Q08ET23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TYROBPO439143I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0045087innate immune response TAS--

    SIGLEC14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC14 (SIG14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIGLEC14 gene: 
    NM_001098612.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360844(uc002pxf.4) ENST00000533866
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGACATCA
    SIGLEC14 Expression
    About this image

    SIGLEC14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC14 Protein Expression

    UniProtKB/Swiss-Prot: SIG14_HUMAN, Q08ET2
    Tissue specificity: Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also
    detected in lung and testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for SIGLEC14 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    Uncharacterized protein
    62(a)
    29(a)
    many ↔ many
    many ↔ many
    1(105445019-105460545)
    1(105461204-105462282)


    ENSEMBL Gene Tree for SIGLEC14 (if available)
    TreeFam Gene Tree for SIGLEC14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC14 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    11 SIMAP similar genes for SIGLEC14 using alignment to 1 protein entry:     SIG14_HUMAN:
    SIGLEC5    CD33    SIGLEC6    SIGLEC9    SIGLEC12    SIGLEC7
    CEA    SIGLEC11    SIGLEC10    SIGLEC16    SIGLEC8

    SIGLEC14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SIGLEC14
    PGOHUM00000234382


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC14 (see all 142)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556821601,2
    C,F--52145322(+) ACTTCT/CAAGCA 1 -- ds50012Minor allele frequency- C:0.09NA 122
    rs621068811,2
    C,F--52145331(+) CAATCC/TGTGAA 1 -- ds50014Minor allele frequency- T:0.22NA WA 242
    rs1438375381,2
    --52145357(+) AGGGGA/GAAGAA 1 -- ds50010--------
    rs786590431,2
    C--52145446(+) CAGAAC/TCAGTG 1 -- ds50013Minor allele frequency- T:0.09NA WA 240
    rs104059901,2
    C,F,A,H--52145524(+) tgataC/Tgtgta 1 -- ds50014Minor allele frequency- T:0.03NS CSA WA 340
    rs1823429851,2
    --52145525(+) GATACA/GTGTAA 1 -- ds50010--------
    rs341973731,2
    C,F--52145535(+) ACAACG/ATGGAT 1 -- ds50017Minor allele frequency- A:0.22NA CSA WA EA 366
    rs359919971,2
    C--52145758(+) AAAAAA/-GACAT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs1468529351,2
    --52145918(+) CAAATG/TCTGCC 1 -- ut310--------
    rs1406508381,2
    --52145982(+) AGAAGA/GTAACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SIGLEC14 (52145806 - 52150132 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIGLEC14 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv656e199CNV Deletion23128226
    esv2516533CNV Deletion19546169
    nsv2532CNV Loss18451855
    dgv593n67CNV Loss20364138
    esv27396CNV Loss19812545
    dgv595n67CNV Loss20364138
    nsv458725CNV Loss19166990
    dgv30n47CNV Loss21111241
    nsv828612CNV Loss20364138
    nsv828611CNV Loss20364138

    Human Gene Mutation Database (HGMD): SIGLEC14
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    SIGLEC14 for disorders           About GeneDecksing


    Export disorders for SIGLEC14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SIGLEC14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PubMed id 17012248)1, 2, 3 Angata T.... Nakamura M. (FASEB J. 2006)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. (PubMed id 23519826)1 Angata T....Taniguchi N. (Cell. Mol. Life Sci. 2013)
    4. Deletion polymorphism of SIGLEC14 and its functional implications. (PubMed id 19369701)1 Yamanaka M....Narimatsu H. (Glycobiology 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100049587 HGNC: 32926 Ensembl:ENSG00000254415 euGenes: HUgn100049587 ECgene: SIGLEC14
    H-InvDB: SIGLEC14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC14 gene:
    Search GeneIP for patents involving SIGLEC14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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