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Aliases for SIGLEC12 Gene

Aliases for SIGLEC12 Gene

  • Sialic Acid Binding Ig-Like Lectin 12 (Gene/Pseudogene) 2 3
  • SIGLECL1 3 4 6
  • SLG 3 4 6
  • Sialic Acid-Binding Ig-Like Lectin-Like 1 3 4
  • SIGLEC-Like 1 2 3
  • S2V 3 6
  • Sialic Acid Binding Ig-Like Lectin 12 2
  • Sialic Acid-Binding Ig-Like Lectin 12 3
  • Siglec-XII 3
  • Siglec-12 4
  • Siglec-L1 4

External Ids for SIGLEC12 Gene

Previous HGNC Symbols for SIGLEC12 Gene

  • SIGLECL1

Previous GeneCards Identifiers for SIGLEC12 Gene

  • GC19M056687
  • GC19M051913
  • GC19M051994

Summaries for SIGLEC12 Gene

Entrez Gene Summary for SIGLEC12 Gene

  • Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SIGLEC12 Gene

SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC12 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC12 Gene

Genomics for SIGLEC12 Gene

Regulatory Elements for SIGLEC12 Gene

Genomic Location for SIGLEC12 Gene

Start:
51,491,227 bp from pter
End:
51,501,789 bp from pter
Size:
10,563 bases
Orientation:
Minus strand

Genomic View for SIGLEC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC12 Gene

Proteins for SIGLEC12 Gene

  • Protein details for SIGLEC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PQ1-SIG12_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 12
    Protein Accession:
    Q96PQ1
    Secondary Accessions:
    • Q8IYH7

    Protein attributes for SIGLEC12 Gene

    Size:
    595 amino acids
    Molecular mass:
    64984 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC12 Gene

Proteomics data for SIGLEC12 Gene at MOPED

Post-translational modifications for SIGLEC12 Gene

  • Glycosylation at Asn140, Asn179, Asn230, Asn290, Asn360, Asn367, and Asn385
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC12 Gene

No data available for DME Specific Peptides for SIGLEC12 Gene

Domains for SIGLEC12 Gene

Gene Families for SIGLEC12 Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SIGLEC12 Gene

Suggested Antigen Peptide Sequences for SIGLEC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PQ1

UniProtKB/Swiss-Prot:

SIG12_HUMAN :
  • Q96PQ1
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC12: view

Function for SIGLEC12 Gene

Molecular function for SIGLEC12 Gene

UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Ontology (GO) - Molecular Function for SIGLEC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC12: view

Phenotypes for SIGLEC12 Gene

GenomeRNAi human phenotypes for SIGLEC12:
genes like me logo Genes that share phenotypes with SIGLEC12: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGLEC12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIGLEC12 Gene

Localization for SIGLEC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC12 Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for SIGLEC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC12: view

No data available for Subcellular locations from COMPARTMENTS for SIGLEC12 Gene

Pathways for SIGLEC12 Gene

SuperPathways for SIGLEC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC12: view

No data available for Pathways by source for SIGLEC12 Gene

Compounds for SIGLEC12 Gene

(3) Novoseek inferred chemical compound relationships for SIGLEC12 Gene

Compound -log(P) Hits PubMed IDs
sialic acid 68.3 6
tyrosine 21.1 2
calcium 0 1
genes like me logo Genes that share compounds with SIGLEC12: view

Transcripts for SIGLEC12 Gene

mRNA/cDNA for SIGLEC12 Gene

(5) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIGLEC12 Gene

Sialic acid binding Ig-like lectin 12 (gene/pseudogene):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGLEC12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SIGLEC12
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC12 Gene

No ASD Table

Relevant External Links for SIGLEC12 Gene

GeneLoc Exon Structure for
SIGLEC12
ECgene alternative splicing isoforms for
SIGLEC12

Expression for SIGLEC12 Gene

mRNA expression in normal human tissues for SIGLEC12 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC12 Gene

This gene is overexpressed in Spleen (28.0) and Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC12 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC12 Gene Hs.249741

mRNA Expression by UniProt/SwissProt for SIGLEC12 Gene

Q96PQ1-SIG12_HUMAN
Tissue specificity: Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis
genes like me logo Genes that share expressions with SIGLEC12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC12 Gene

Orthologs for SIGLEC12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 78 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglece 36
  • 50 (a)
OneToMany
Species with no ortholog for SIGLEC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC12 Gene

ENSEMBL:
Gene Tree for SIGLEC12 (if available)
TreeFam:
Gene Tree for SIGLEC12 (if available)

Paralogs for SIGLEC12 Gene

Paralogs for SIGLEC12 Gene

Selected SIMAP similar genes for SIGLEC12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC12: view

Variants for SIGLEC12 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs968491 -- 51,499,234(+) AGACA(A/C)GGAGT intron-variant
rs1551555 -- 51,502,080(+) CCCAT(A/G)TGGCC upstream-variant-2KB
rs1551556 -- 51,502,415(+) ATTCC(A/G)TGTGT upstream-variant-2KB
rs1551557 -- 51,502,426(+) TGATA(A/C)ACACC upstream-variant-2KB
rs1551558 -- 51,502,428(+) ATACA(C/T)ACCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC12 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
nsv469584 CNV Complex 16826518
esv33175 CNV Gain 17666407

Relevant External Links for SIGLEC12 Gene

HapMap Linkage Disequilibrium report
SIGLEC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC12 Gene

Disorders for SIGLEC12 Gene

Relevant External Links for SIGLEC12

Genetic Association Database (GAD)
SIGLEC12
Human Genome Epidemiology (HuGE) Navigator
SIGLEC12
genes like me logo Genes that share disorders with SIGLEC12: view

No data available for UniProtKB/Swiss-Prot for SIGLEC12 Gene

Publications for SIGLEC12 Gene

  1. Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs. (PMID: 11409877) Foussias G. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. (PMID: 11328818) Yu Z. … Shen S.H. (J. Biol. Chem. 2001) 2 3
  3. A second uniquely human mutation affecting sialic acid biology. (PMID: 11546777) Angata T. … Varki A. (J. Biol. Chem. 2001) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SIGLEC12 Gene

Sources for SIGLEC12 Gene

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