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SIGLEC12 Gene

protein-coding   GIFtS: 49
GCID: GC19M051994

Sialic Acid Binding Ig-Like Lectin 12 (Gene/Pseudogene)

(Previous names: SIGLEC-like 1, sialic acid binding Ig-like lectin 12)
(Previous symbol: SIGLECL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 12 (Gene/Pseudogene)1 2     Sialic Acid Binding Ig-Like Lectin 121
SIGLECL11 2 3 5     Siglec-XII2
SLG2 3 5     Sialic Acid-Binding Ig-Like Lectin 122
SIGLEC-Like 11 2     Siglec-123
Sialic Acid-Binding Ig-Like Lectin-Like 12 3     Siglec-L13
S2V2 5     

External Ids:    HGNC: 154821   Entrez Gene: 898582   Ensembl: ENSG000002545217   OMIM: 6060945   UniProtKB: Q96PQ13   

Export aliases for SIGLEC12 gene to outside databases

Previous GC identifers: GC19M056687 GC19M051913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIGLEC12 Gene:
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the
immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different
sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like
subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like
domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and
SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2
domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved
in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located
in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for SIGLEC12 Gene:
SIGLEC12 (sialic acid binding Ig-like lectin 12 (gene/pseudogene)) is a protein-coding gene. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIG12_HUMAN, Q96PQ1
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid
recognition site may be masked by cis interactions with sialic acids on the same cell surface

Gene Wiki entry for SIGLEC12 (Sialic acid-binding Ig-like lectin 12) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC12 gene promoter:
         MEF-2A   MEF-2   ARP-1   aMEF-2   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC12 promoter sequence
   Search Chromatin IP Primers for SIGLEC12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

SIGLEC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051994:  view genomic region     (about GC identifiers)

Start:
51,994,611 bp from pter      End:
52,005,043 bp from pter
Size:
10,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIG12_HUMAN, Q96PQ1 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 12 precursor  
Size: 595 amino acids; 64984 Da
Secondary accessions: Q8IYH7
Alternative splicing: 2 isoforms:  Q96PQ1-1   Q96PQ1-2   

Explore the universe of human proteins at neXtProt for SIGLEC12: NX_Q96PQ1

Post-translational modifications: 

  • Glycosylation2 at Asn140, Asn179, Asn230, Asn290, Asn360, Asn367, Asn385
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_201586.1  NP_443729.1  

    ENSEMBL proteins: 
     ENSP00000469791   ENSP00000291707   ENSP00000472873  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96PQ1

    ProtoNet protein and cluster: Q96PQ1

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SIG12_HUMAN, Q96PQ1
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with SIGLEC12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIG12_HUMAN, Q96PQ1
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid
    recognition site may be masked by cis interactions with sialic acids on the same cell surface

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SIGLEC12           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC12:
     Decreased cilium length after  

    Animal Models:
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    Sino Biological Human cDNA Clone for SIGLEC12
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIG12_HUMAN, Q96PQ1: Membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SIGLEC12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC12
    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC12

    3 Interacting proteins for SIGLEC12 (Q96PQ13) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CMASQ8NFW83I2D: score=1 
    PTPN11Q061243I2D: score=1 
    PTPN6P293503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with SIGLEC12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC12 (SIG12)

    3 Novoseek inferred chemical compound relationships for SIGLEC12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sialic acid 68.3 6 15597323 (1), 11358961 (1), 16732727 (1), 15481154 (1) (see all 6)
    tyrosine 21.1 3 7895172 (2)
    calcium 0 1 7895172 (1)



    Find genes that share compounds with SIGLEC12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC12 gene (2 alternative transcripts): 
    NM_033329.2  NM_053003.3  

    Unigene Cluster for SIGLEC12:

    Sialic acid binding Ig-like lectin 12 (gene/pseudogene)
    Hs.249741  [show with all ESTs]
    Unigene Representative Sequence: AY358140
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596742 ENST00000291707(uc002pww.1 uc002pwx.1 uc010eoy.1)
    ENST00000598614
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat SIGLEC12

    Additional mRNA sequence: 

    AF282256.1 AK095919.1 AK225931.1 AY358140.1 BC035809.1 

    2 DOTS entries:

    DT.100016662  DT.99957558 

    9 AceView cDNA sequences:

    AY358140 NM_053003 BC035809 AF282256 NM_033329 AK095919 BP338210 AI132995 
    BM922492 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGCAACA
    SIGLEC12 Expression
    About this image

    SIGLEC12 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.249741

    UniProtKB/Swiss-Prot: SIG12_HUMAN, Q96PQ1
    Tissue specificity: Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower
    expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly
    expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus,
    trachea, stomach, lung, adrenal gland, fetal brain and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for SIGLEC12 (if available)
    TreeFam Gene Tree for SIGLEC12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC12 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    8 SIMAP similar genes for SIGLEC12 using alignment to 2 protein entries:     SIG12_HUMAN (see all proteins):
    SIGLEC7    SIGLEC9    SIGLEC6    SIGLEC8    SIGLEC14    SIGLEC10
    SIGLEC16    MAG

    Find genes that share paralogs with SIGLEC12           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for SIGLEC12
    PGOHUM00000234737 PGOHUM00000234738 PGOHUM00000234741 PGOHUM00000234743 PGOHUM00000243760


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC12 (see all 503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427548061,2
    Cuntested152001433(+) TCCCCA/C/TAGGTC 4 * W stg10--------
    rs754117211,2
    C--48327071(+) GTACTA/GGCAAG 2 -- ds50010--------
    rs1500033371,2
    C--48327097(+) AGTCAC/TACGGA 2 -- ds50010--------
    rs1452304611,2
    --51994189(+) AGCGCC/GTCCTC 2 -- ds50010--------
    rs1491446371,2
    --51994283(+) CCAATC/TAGTGG 2 -- ds50010--------
    rs761611951,2
    C,F--51994299(+) CCACTC/GAGTGC 2 -- ds50011Minor allele frequency- G:0.04EA 120
    rs104214381,2
    C,F,A,H--51994351(+) TTCAGC/TCCTGC 2 -- ds500112Minor allele frequency- T:0.09NA WA CSA EA 374
    rs557594691,2
    C,F--51994367(+) GTACCG/TGAGCG 2 -- ds500110Minor allele frequency- T:0.25NA WA CSA EA 370
    rs1125313651,2
    C--51994465(+) TTTAA-/TT/TTT
            
    TTTTT
    4 -- ds5001 cds11CSA 2
    rs557741141,2
    C--51994466(+) TTTAA-/TTTTTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIGLEC12 (51994611 - 52005043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SIGLEC12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33175CNV Gain17666407
    esv638CNV CNV17122850
    nsv469584CNV Complex16826518
    dgv1109e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SIGLEC12
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SIGLEC12
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606094    OMIM disorders: --


    Find genes that share disorders with SIGLEC12           About GenesLikeMe

    Genetic Association Database (GAD): SIGLEC12
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC12 (4 documents)

    Export disorders for SIGLEC12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC12 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with SIGLEC12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and molecular characterization of two splice variants of a new putative member of the Siglec-3-like subgroup of Siglecs. (PubMed id 11409877)1, 2, 3, 9 Foussias G....Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001)
    2. SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. (PubMed id 21555517)1, 3 Mitra N....Varki A. (J. Biol. Chem. 2011)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. A second uniquely human mutation affecting sialic acid biology. (PubMed id 11546777)1, 2 Angata T.... Varki A. (J. Biol. Chem. 2001)
    7. Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs. (PubMed id 11328818)1, 3 Yu Z....Shen S.H. (J. Biol. Chem. 2001)
    8. Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. (PubMed id 23690342)1 McDonough C.W....Johnson J.A. (Hypertension 2013)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89858 HGNC: 15482 AceView: SIGLECL1 Ensembl:ENSG00000254521 euGenes: HUgn89858
    ECgene: SIGLEC12 H-InvDB: SIGLEC12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC12 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_276

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC12 gene:
    Search GeneIP for patents involving SIGLEC12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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