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Aliases for SIGLEC11 Gene

Aliases for SIGLEC11 Gene

  • Sialic Acid Binding Ig-Like Lectin 11 2 3
  • Siglec-11 3 4
  • Sialic Acid-Binding Ig-Like Lectin 11 3
  • Sialic Acid-Binding Lectin 11 4

External Ids for SIGLEC11 Gene

Summaries for SIGLEC11 Gene

Entrez Gene Summary for SIGLEC11 Gene

  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SIGLEC11 Gene

SIGLEC11 (Sialic Acid Binding Ig-Like Lectin 11) is a Protein Coding gene. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC11 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC11 Gene

Genomics for SIGLEC11 Gene

Genomic Location for SIGLEC11 Gene

Start:
49,948,985 bp from pter
End:
49,961,179 bp from pter
Size:
12,195 bases
Orientation:
Minus strand

Genomic View for SIGLEC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC11 Gene

Regulatory Elements for SIGLEC11 Gene

Proteins for SIGLEC11 Gene

  • Protein details for SIGLEC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RL6-SIG11_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 11
    Protein Accession:
    Q96RL6
    Secondary Accessions:

    Protein attributes for SIGLEC11 Gene

    Size:
    698 amino acids
    Molecular mass:
    75795 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
    SequenceCaution:
    • Sequence=AAK72907.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ88502.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIGLEC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC11 Gene

Proteomics data for SIGLEC11 Gene at MOPED

Post-translational modifications for SIGLEC11 Gene

  • Phosphorylated on tyrosine residues
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn55, Asn90, Asn262, Asn366, Asn375, Asn497, and Asn515

Other Protein References for SIGLEC11 Gene

No data available for DME Specific Peptides for SIGLEC11 Gene

Domains for SIGLEC11 Gene

Gene Families for SIGLEC11 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

Suggested Antigen Peptide Sequences for SIGLEC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RL6

UniProtKB/Swiss-Prot:

SIG11_HUMAN
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q96RL6
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q96RL6
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q96RL6
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • Q96RL6
genes like me logo Genes that share domains with SIGLEC11: view

Function for SIGLEC11 Gene

Molecular function for SIGLEC11 Gene

UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules

Gene Ontology (GO) - Molecular Function for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC11: view

Phenotypes for SIGLEC11 Gene

GenomeRNAi human phenotypes for SIGLEC11:
genes like me logo Genes that share phenotypes with SIGLEC11: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIGLEC11 Gene

Localization for SIGLEC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC11 Gene COMPARTMENTS Subcellular localization image for SIGLEC11 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC11: view

Pathways for SIGLEC11 Gene

SuperPathways for SIGLEC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC11: view

No data available for Pathways by source for SIGLEC11 Gene

Transcripts for SIGLEC11 Gene

mRNA/cDNA for SIGLEC11 Gene

Unigene Clusters for SIGLEC11 Gene

Sialic acid binding Ig-like lectin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC11 Gene

No ASD Table

Relevant External Links for SIGLEC11 Gene

GeneLoc Exon Structure for
SIGLEC11
ECgene alternative splicing isoforms for
SIGLEC11

Expression for SIGLEC11 Gene

mRNA expression in normal human tissues for SIGLEC11 Gene

mRNA differential expression in normal tissues according to GTEx for SIGLEC11 Gene

This gene is overexpressed in Ovary (23.4), Spleen (8.6), and Adrenal Gland (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC11 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC11 Gene Hs.661852

mRNA Expression by UniProt/SwissProt for SIGLEC11 Gene

Q96RL6-SIG11_HUMAN
Tissue specificity: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia
genes like me logo Genes that share expressions with SIGLEC11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SIGLEC11 Gene

Orthologs for SIGLEC11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC11 35
  • 97.71 (n)
  • 95.99 (a)
SIGLEC11 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Siglecg 36
  • 54 (a)
OneToMany
Species with no ortholog for SIGLEC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC11 Gene

ENSEMBL:
Gene Tree for SIGLEC11 (if available)
TreeFam:
Gene Tree for SIGLEC11 (if available)

Paralogs for SIGLEC11 Gene

Paralogs for SIGLEC11 Gene

Selected SIMAP similar genes for SIGLEC11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIGLEC11: view

Variants for SIGLEC11 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs283513 -- 49,962,085(+) ctgtc(A/G)cccag upstream-variant-2KB
rs283514 -- 49,955,974(+) cgggc(A/G)cagtg intron-variant
rs364111 -- 49,959,383(-) GCAGC(A/G)AGCCC reference, missense, nc-transcript-variant
rs374070 -- 49,954,464(-) AGCTC(A/G)AGCAG intron-variant
rs383441 -- 49,948,732(+) accac(C/T)acatc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC11 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv54n68 CNV Loss 17160897
nsv458720 CNV Gain 19166990
nsv7309 OTHER Inversion 18451855

Relevant External Links for SIGLEC11 Gene

HapMap Linkage Disequilibrium report
SIGLEC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC11 Gene

Disorders for SIGLEC11 Gene

Relevant External Links for SIGLEC11

Human Genome Epidemiology (HuGE) Navigator
SIGLEC11
genes like me logo Genes that share disorders with SIGLEC11: view

No data available for UniProtKB/Swiss-Prot for SIGLEC11 Gene

Publications for SIGLEC11 Gene

  1. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PMID: 11986327) Angata T. … Varki A. (J. Biol. Chem. 2002) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. A human-specific gene in microglia. (PMID: 16151003) Hayakawa T. … Varki A. (Science 2005) 3
  4. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PMID: 18629938) Cao H. … Barrow A.D. (Eur. J. Immunol. 2008) 3
  5. Alleviation of neurotoxicity by microglial human Siglec-11. (PMID: 20203208) Wang Y. … Neumann H. (J. Neurosci. 2010) 3

Products for SIGLEC11 Gene

Sources for SIGLEC11 Gene

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