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SIGLEC11 Gene

protein-coding   GIFtS: 50
GCID: GC19M050457

Sialic Acid Binding Ig-Like Lectin 11

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 111 2
Sialic Acid-Binding Ig-Like Lectin 112
siglec-112
Siglec-113
Sialic Acid-Binding Lectin 113

External Ids:    HGNC: 156221   Entrez Gene: 1141322   Ensembl: ENSG000001616407   OMIM: 6071575   UniProtKB: Q96RL63   

Export aliases for SIGLEC11 gene to outside databases

Previous GC identifers: GC19M051110 GC19M050820 GC19M055128 GC19M055144 GC19M055089 GC19M050412 GC19M046828 GC19M050456


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIGLEC11 Gene:
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface
lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid
recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and
immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SIGLEC11 Gene:
SIGLEC11 (sialic acid binding Ig-like lectin 11) is a protein-coding gene. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIG11_HUMAN, Q96RL6
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic
acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced
tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal
transduction through dephosphorylation of signaling molecules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC11 gene promoter:
         E2F-3a   E2F   E2F-1   FOXO1a   E2F-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC11 promoter sequence
   Search Chromatin IP Primers for SIGLEC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

SIGLEC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050457:  view genomic region     (about GC identifiers)

Start:
50,452,242 bp from pter      End:
50,464,429 bp from pter
Size:
12,188 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIG11_HUMAN, Q96RL6 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 11 precursor  
Size: 698 amino acids; 75795 Da
Subunit: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=AAK72907.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAQ88502.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Alternative splicing: 2 isoforms:  Q96RL6-1   Q96RL6-2   

Explore the universe of human proteins at neXtProt for SIGLEC11: NX_Q96RL6

Explore proteomics data for SIGLEC11 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues1
  • Glycosylation2 at Asn55, Asn90, Asn262, Asn366, Asn375, Asn497, Asn515
  • Modification sites at PhosphoSitePlus

  • See SIGLEC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128635.1  NP_443116.2  

    ENSEMBL proteins: 
     ENSP00000412361   ENSP00000398891   ENSP00000407387  

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    antibodies-online proteins for SIGLEC11 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q96RL6

    ProtoNet protein and cluster: Q96RL6

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: SIG11_HUMAN, Q96RL6
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIGLEC11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIG11_HUMAN, Q96RL6
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic
    acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced
    tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal
    transduction through dephosphorylation of signaling molecules

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SIGLEC11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIGLEC11:
     Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SIGLEC11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIG11_HUMAN, Q96RL6: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SIGLEC11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIGLEC11
    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SIGLEC11 (Q96RL63 ENSP000004123614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=2 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=2 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with SIGLEC11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIGLEC11 (SIG11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC11 gene (2 alternative transcripts): 
    NM_001135163.1  NM_052884.2  

    Unigene Cluster for SIGLEC11:

    Sialic acid binding Ig-like lectin 11
    Hs.661852  [show with all ESTs]
    Unigene Representative Sequence: AF337818
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447370(uc010ybh.2 uc010ybi.2) ENST00000426971 ENST00000426296

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    Additional mRNA sequence: 

    AB072038.1 AF337818.1 AY358135.1 

    3 DOTS entries:

    DT.95119118  DT.100755271  DT.97780149 

    22 AceView cDNA sequences:

    BX097151 AA411815 AI223084 AA341128 CD369505 NM_052884 AY358135 BM544297 
    AA403084 BF969219 AB072038 BX345667 BX324896 BM544044 AF337818 BG826221 
    BF308356 BX345666 AA328836 BM544269 BF205116 BX324895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGGGCG
    SIGLEC11 Expression
    About this image

    SIGLEC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661852

    UniProtKB/Swiss-Prot: SIG11_HUMAN, Q96RL6
    Tissue specificity: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain
    microglia

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for SIGLEC11 (if available)
    TreeFam Gene Tree for SIGLEC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC11 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC142  SIGLEC62  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    10 SIMAP similar genes for SIGLEC11 using alignment to 2 protein entries:     SIG11_HUMAN (see all proteins):
    SIGLEC16    SIGLEC10    CD33    SIGLEC7    SIGLEC14    SIGLEC6
    SIGLEC9    CEA    SIGLECL1    SIGLEC5

    Find genes that share paralogs with SIGLEC11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC11 (see all 547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797049701,2
    F--50455963(+) GAAAGA/GAAAAC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1995529591,2
    C--50456506(-) TTCTGA/GAATCA 2 -- int10--------
    rs797447321,2
    F--50456935(+) TAATAG/AGAGCT 2 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs767333241,2
    F--50456938(+) TAGGAG/ACTGCC 2 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs567305931,2
    C,F--50456993(+) AAGTAG/ACTTCT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs765425091,2
    C--50457009(+) CTCCCG/ATAATA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs775208941,2
    C--50457070(+) GTAAAG/AGAAGG 2 -- int11Minor allele frequency- A:0.50NA 2
    rs739320681,2
    C,F--50457125(+) TTACAG/AAACTT 2 -- int12Minor allele frequency- A:0.50WA NA 4
    rs561394731,2
    C,F--50457187(+) GAGAAC/TTCTCT 2 -- int12Minor allele frequency- T:0.10WA 120
    rs587685271,2
    C,F--50457394(+) TTATTG/ACAAAA 2 -- int12Minor allele frequency- A:0.10WA 120

    HapMap Linkage Disequilibrium report for SIGLEC11 (50452242 - 50464429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SIGLEC11:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv54n68CNV Loss17160897
    nsv458720CNV Gain19166990
    nsv9739CNV Gain+Loss18304495
    nsv7309OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607157    OMIM disorders: --


    Find genes that share disorders with SIGLEC11           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SIGLEC11 (1 document)

    Export disorders for SIGLEC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SIGLEC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. (PubMed id 11986327)1, 2, 3 Angata T....Varki A. (J. Biol. Chem. 2002)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology. (PubMed id 21467073)1 Wang X....Varki N. (Glycobiology 2011)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    5. Alleviation of neurotoxicity by microglial human Siglec-11. (PubMed id 20203208)1 Wang Y. and Neumann H. (J. Neurosci. 2010)
    6. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. (PubMed id 18629938)1 Cao H....Barrow A.D. (Eur. J. Immunol. 2008)
    7. A human-specific gene in microglia. (PubMed id 16151003)1 Hayakawa T....Varki A. (Science 2005)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines. (PubMed id 15947549)9 Ying-Tao Z....Yi-Li W. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114132 HGNC: 15622 AceView: SIGLEC11 Ensembl:ENSG00000161640 euGenes: HUgn114132
    ECgene: SIGLEC11 H-InvDB: SIGLEC11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC11 gene:
    Search GeneIP for patents involving SIGLEC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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