Aliases for SIGLEC10 Gene
External Ids for SIGLEC10 Gene
Previous GeneCards Identifiers for SIGLEC10 Gene
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
GeneCards Summary for SIGLEC10 Gene
SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include Stargardt Disease. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
UniProtKB/Swiss-Prot for SIGLEC10 Gene
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.