Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIGLEC10 Gene

Aliases for SIGLEC10 Gene

  • Sialic Acid Binding Ig Like Lectin 10 2 3
  • Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7 2 3
  • Sialic Acid Binding Ig-Like Lectin 10 2 5
  • Siglec-Like Protein 2 3 4
  • Siglec-Like Gene 2 2 3
  • SIGLEC-10 3 4
  • SLG2 3 4
  • PRO940 3

External Ids for SIGLEC10 Gene

Previous GeneCards Identifiers for SIGLEC10 Gene

  • GC19M052544
  • GC19M052275
  • GC19M056589
  • GC19M056606
  • GC19M056607
  • GC19M056608
  • GC19M051915
  • GC19M051916

Summaries for SIGLEC10 Gene

Entrez Gene Summary for SIGLEC10 Gene

  • SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

GeneCards Summary for SIGLEC10 Gene

SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot for SIGLEC10 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene Wiki entry for SIGLEC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC10 Gene

Genomics for SIGLEC10 Gene

Regulatory Elements for SIGLEC10 Gene

Promoters for SIGLEC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC10 Gene

Chromosome:
19
Start:
51,410,021 bp from pter
End:
51,417,803 bp from pter
Size:
7,783 bases
Orientation:
Minus strand

Genomic View for SIGLEC10 Gene

Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC10 Gene

Proteins for SIGLEC10 Gene

  • Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC7-SIG10_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 10
    Protein Accession:
    Q96LC7
    Secondary Accessions:
    • A8K1I5
    • A8K3C7
    • C9JJ33
    • C9JM10
    • F8W917
    • Q3MIR5
    • Q6UXI8
    • Q96G54
    • Q96LC8

    Protein attributes for SIGLEC10 Gene

    Size:
    697 amino acids
    Molecular mass:
    76592 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.

    Alternative splice isoforms for SIGLEC10 Gene

neXtProt entry for SIGLEC10 Gene

Proteomics data for SIGLEC10 Gene at MOPED

Post-translational modifications for SIGLEC10 Gene

  • Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Glycosylation at Asn 100, Asn 355, Asn 364, Asn 486, and Asn 504
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SIGLEC10 Gene

Domains & Families for SIGLEC10 Gene

Suggested Antigen Peptide Sequences for SIGLEC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LC7

UniProtKB/Swiss-Prot:

SIG10_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC10: view

Function for SIGLEC10 Gene

Molecular function for SIGLEC10 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
genes like me logo Genes that share phenotypes with SIGLEC10: view

Animal Models for SIGLEC10 Gene

MGI Knock Outs for SIGLEC10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGLEC10

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene

Localization for SIGLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC10 Gene COMPARTMENTS Subcellular localization image for SIGLEC10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 2
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Pathways & Interactions for SIGLEC10 Gene

genes like me logo Genes that share pathways with SIGLEC10: view

Pathways by source for SIGLEC10 Gene

SIGNOR curated interactions for SIGLEC10 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIGLEC10 Gene

None

Drugs & Compounds for SIGLEC10 Gene

No Compound Related Data Available

Transcripts for SIGLEC10 Gene

Unigene Clusters for SIGLEC10 Gene

Sialic acid binding Ig-like lectin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SIGLEC10 Gene

GeneLoc Exon Structure for
SIGLEC10
ECgene alternative splicing isoforms for
SIGLEC10

Expression for SIGLEC10 Gene

mRNA expression in normal human tissues for SIGLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene

This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for SIGLEC10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC10 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene Hs.284813

mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene

Q96LC7-SIG10_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
genes like me logo Genes that share expression patterns with SIGLEC10: view

Protein tissue co-expression partners for SIGLEC10 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SIGLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIGLEC10 35
  • 75.71 (n)
  • 64.44 (a)
-- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SIGLEC10 35
  • 76.38 (n)
  • 65.24 (a)
-- 36
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Siglecg 35
  • 72.44 (n)
  • 61.6 (a)
Siglecg 16
Siglecg 36
  • 60 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC10 35
  • 98.76 (n)
  • 98.28 (a)
SIGLEC10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Siglec10 35
  • 74.5 (n)
  • 64.02 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732062 35
  • 47.09 (n)
  • 41.28 (a)
Species with no ortholog for SIGLEC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC10 Gene

ENSEMBL:
Gene Tree for SIGLEC10 (if available)
TreeFam:
Gene Tree for SIGLEC10 (if available)

Paralogs for SIGLEC10 Gene

Pseudogenes.org Pseudogenes for SIGLEC10 Gene

genes like me logo Genes that share paralogs with SIGLEC10: view

Variants for SIGLEC10 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_019955 -
VAR_019956 -
rs1833786 -- 51,418,250(+) CCCAG(A/C/G)CTGCA upstream-variant-2KB
rs1833787 -- 51,418,352(+) CACGC(A/G)CCACC upstream-variant-2KB
rs4801865 -- 51,419,540(+) ctggg(A/G)ctaca upstream-variant-2KB

Variation tolerance for SIGLEC10 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC10 Gene

HapMap Linkage Disequilibrium report
SIGLEC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SIGLEC10 Gene

Disorders for SIGLEC10 Gene

Relevant External Links for SIGLEC10

Human Genome Epidemiology (HuGE) Navigator
SIGLEC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC10

No disorders were found for SIGLEC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene

Publications for SIGLEC10 Gene

  1. Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J. … Crocker P.R. (Biochem. J. 2001) 2 3 4 67
  2. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef G.M. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 3 23
  3. Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. (PMID: 25450598) Zhang P. … Wu K. (J. Surg. Res. 2015) 3
  4. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. (PMID: 25320078) LAoubli H. … Varki A. (J. Biol. Chem. 2014) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for SIGLEC10 Gene

Sources for SIGLEC10 Gene

Back to Top

Content