SIGLEC10 Gene
protein-coding GIFtS: 51
GCID: GC19M051916
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|
sialic acid binding Ig-like lectin 10
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Aliases
for SIGLEC10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sialic Acid Binding Ig-Like Lectin 101 2 | | MGC1267741 | | SLG21 2 3 | | Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 72 | | PRO9401 2 | | Sialic Acid-Binding Ig-Like Lectin 102 | | SIGLEC-101 2 | | Siglec-Like Gene 22 | | Siglec-Like Protein 22 3 | | Siglec-103 |
Export aliases for SIGLEC10 gene to outside databasesPrevious GC identifers: GC19M052544 GC19M052275 GC19M056589 GC19M056606 GC19M056607 GC19M056608 GC19M051915 |
Summaries
for SIGLEC10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIGLEC10:
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 ormore cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cellsof the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).(supplied by OMIM, Jul2002)
UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions withsialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand inducedtyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signaltransduction through dephosphorylation of signaling molecules
Gene Wiki entry for SIGLEC10
|
Genomic Views
for SIGLEC10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIGLEC10 gene promoter:
E2F-4 E2F-3a E2F-5 NRSF form 1 E2F-2 NRSF form 2 HEN1 E2F E2F-1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIGLEC10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.3SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M051916: view genomic region
(about GC identifiers)
Start:
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51,913,275 bp from pter |
End:
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51,921,057 bp from pter |
Size:
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7,783 bases |
Orientation:
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minus strand |
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Proteins
for SIGLEC10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7 (See
protein sequence)Recommended Name: Sialic acid-binding Ig-like lectin 10 precursor Size: 697 amino acids; 76592 Da
Subunit: Interacts with PTPN6/SHP-1 upon phosphorylation
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 5: Secreted
Secondary accessions: A8K1I5 A8K3C7 C9JJ33 C9JM10 F8W917 Q3MIR5 Q6UXI8 Q96G54 Q96LC8Alternative splicing: 9 isoforms: Q96LC7-1 Q96LC7-2 Q96LC7-3 Q96LC7-4 Q96LC7-5 Q96LC7-6 Q96LC7-7 Q96LC7-8 Q96LC7-9 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIGLEC10: NX_Q96LC7
Post-translational modifications:
Phosphorylation of Tyr-667 is involved in binding to PTPN61
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LC7
SIGLEC10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001164627.1 NP_001164628.1 NP_001164629.1 NP_001164630.1 NP_001164631.1 NP_001164632.1 NP_149121.2
ENSEMBL proteins: ENSP00000342389 ENSP00000408387 ENSP00000431444 ENSP00000414324 ENSP00000389132 ENSP00000345243 ENSP00000435281 ENSP00000433838 ENSP00000396742 ENSP00000395475 ENSP00000348646
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SIGLEC10 for ontologies About GeneDecksing
SIGLEC10 Antibody Products:
Assay Products for SIGLEC10: |
Protein
Domains /
Families
for SIGLEC10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIGLEC10 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q96LC7ProtoNet protein and cluster: Q96LC7 3 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB003599 Immunoglobulin subtype IPB013162 CD80-like C2-set immunoglobulin
UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif(ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2domain of several SH2-containing phosphatasesSimilarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIGLEC10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds toalpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions withsialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand inducedtyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signaltransduction through dephosphorylation of signaling molecules
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 7): SIGLEC10 (NM_033130) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030246 | carbohydrate binding |
-- | -- |
SIGLEC10 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Siglecgtm1Lnit for SIGLEC10
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Siglecg):
SIGLEC10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SIGLEC10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC10
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for SIGLEC10 (Q96LC72, 3 ENSP000003452434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
SIGLEC10 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIGLEC10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIGLEC10
Search CenterWatch for drugs/clinical trials and news about SIGLEC10 / SIG10
|
Transcripts
for SIGLEC10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIGLEC10 gene (7 alternative transcripts): NM_001171156.1 NM_001171157.1 NM_001171158.1 NM_001171159.1 NM_001171160.1 NM_001171161.1 NM_033130.4 Unigene Cluster for SIGLEC10: Sialic acid binding Ig-like lectin 10 Hs.284813 [show with all ESTs]Unigene Representative Sequence: NM_03313013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000353836(uc002pwp.3 uc002pwo.3 uc021uyl.1 uc002pwq.3 uc010ycz.2 uc002pws.2 uc002pwr.3 uc010ycy.2)
ENST00000357375(uc010eow.3) ENST00000441969 ENST00000525998 ENST00000436984
ENST00000439889 ENST00000339313 ENST00000529627 ENST00000530476 ENST00000524527
ENST00000432469 ENST00000442846 ENST00000356298
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): SIGLEC10 (NM_033130) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC10 |
Additional cDNA sequence: AF310233.1 AF311905.1 AK122619.1 AK289900.1 AK290542.1 AK292025.1 AK294185.1 AK303514.1 AK303717.1 AY032685.1 AY358337.1 BC009955.2 BC101725.1 BC143497.1 BC143500.1 10 DOTS entries: DT.97776255 DT.97826694 DT.97766562 DT.100020416 DT.101981076 DT.121495563 DT.75124112 DT.102822051 DT.92059427 DT.95096582 21 AceView cDNA sequences: BQ002183 BQ711946 BX283650 BC009955 AF311905 BX470328 AF310233 AA321342 AK122619 NM_033130 BP360053 AY032685 AF301007 BM972768 AY358337 AI880327 AI863808 BF663289 AA361770 AI918403 BI912042
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIGLEC10
|
Expression
for SIGLEC10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIGLEC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAACATCAG
About this image
See SIGLEC10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIGLEC10
SOURCE GeneReport for Unigene cluster: Hs.284813
UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cellsubpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix.Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 isalso found in brain. Isoform 4 is specifically found in natural killer cells
SABiosciences Custom PCR Arrays for SIGLEC10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIGLEC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC10 |
Orthologs
for SIGLEC10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIGLEC10 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for SIGLEC10 (if available)
TreeFam Gene Tree for SIGLEC10 (if available) |
Paralogs
for SIGLEC10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIGLEC10 gene
- CD332 SIGLEC17P2 SIGLEC82 SIGLEC52 SIGLEC112 SIGLEC162 SIGLEC62 SIGLEC142
- SIGLEC122 MAG2 SIGLEC72 SIGLEC92
13 SIMAP similar genes for SIGLEC10 using alignment to 6 protein entries: SIG10_HUMAN (see all proteins):SIGLEC16 SIGLEC11 CD33 SIGLECL1 SIGLEC14 SIGLEC7
SIGLEC6 CEA PSG11 SIGLEC5 SIGLEC12 SIGLEC9
SIGLEC8
SIGLEC10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIGLEC10
PGOHUM00000258105
|
Genomic Variants
for SIGLEC10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIGLEC10 (51913275 - 51921057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIGLEC10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC10 |
|
Disorders
/ Diseases
for SIGLEC10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIGLEC10 for disorders About GeneDecksing
OMIM gene information: 606091
OMIM disorders: --
3  diseases for SIGLEC10: About MalaCardsnon-invasive bladder papillary urothelial neoplasm hepatitis b hepatitis
3 diseases from the University of Copenhagen DISEASES database for SIGLEC10:Mucocele of salivary gland Lymphoblastic leukemia Chronic leukemia Human Genome Epidemiology (HuGE) Navigator: SIGLEC10 (1 document)
Export disorders for SIGLEC10 gene to outside databases
|
Publications
for SIGLEC10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIGLEC10 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with SIGLEC10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor. (PubMed id 11284738)1, 2, 3 Munday J.... Crocker P.R. (2001)
- Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PubMed id 11409878)1, 2, 9 Yousef G.M.... Diamandis E.P. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. (PubMed id 12163025)1, 2 Kitzig F.... Sayos J. (2002)
- Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. (PubMed id 11358961)1, 2 Li N.... Cao X. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Human Siglec-10 can bind to vascular adhesion protein -1 and serves as its substrate. (PubMed id 19861682)1 Kivi E....Jalkanen S. (2009)
- Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for SIGLEC10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIGLEC10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIGLEC10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIGLEC10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIGLEC10 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00002 | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_268 |
|
| | |
About This Section
| Patent Information for SIGLEC10 gene:
Search GeneIP for patents involving SIGLEC10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIGLEC10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC10 | | | OriGene Protein Over-expression Lysate for SIGLEC10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIGLEC10 | | OriGene 3'-UTR Clone for SIGLEC10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIGLEC10 | | OriGene Custom Protein Services for SIGLEC10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC10 |
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 | | | SIGLEC10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC10 |
|  |  |  | | | | Search ThermoFisher Antibodies for SIGLEC10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC10 |
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