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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGLEC10 Gene

protein-coding   GIFtS: 53
GCID: GC19M051916

Sialic Acid Binding Ig-Like Lectin 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sialic Acid Binding Ig-Like Lectin 101 2     PRO9402
Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 71 2     SIGLEC-102
Siglec-Like Gene 21 2     Sialic Acid-Binding Ig-Like Lectin 102
Siglec-Like Protein 22 3     Siglec-103
SLG22 3     

External Ids:    HGNC: 156201   Entrez Gene: 897902   Ensembl: ENSG000001425127   OMIM: 6060915   UniProtKB: Q96LC73   

Export aliases for SIGLEC10 gene to outside databases

Previous GC identifers: GC19M052544 GC19M052275 GC19M056589 GC19M056606 GC19M056607 GC19M056608 GC19M051915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIGLEC10 Gene:
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1
or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed
on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).(supplied
by OMIM, Jul 2002)

GeneCards Summary for SIGLEC10 Gene: 
SIGLEC10 (sialic acid binding Ig-like lectin 10) is a protein-coding gene. Diseases associated with SIGLEC10 include non-invasive bladder papillary urothelial neoplasm, and mucocele of salivary gland. An important paralog of this gene is CD33.

UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand
induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block
signal transduction through dephosphorylation of signaling molecules

Gene Wiki entry for SIGLEC10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGLEC10 gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   HEN1   E2F   E2F-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIGLEC10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051916:  view genomic region     (about GC identifiers)

Start:
51,913,275 bp from pter      End:
51,921,057 bp from pter
Size:
7,783 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7 (See protein sequence)
Recommended Name: Sialic acid-binding Ig-like lectin 10 precursor  
Size: 697 amino acids; 76592 Da
Subunit: Interacts with PTPN6/SHP-1 upon phosphorylation
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 5: Secreted
Secondary accessions: A8K1I5 A8K3C7 C9JJ33 C9JM10 F8W917 Q3MIR5 Q6UXI8 Q96G54 Q96LC8
Alternative splicing: 9 isoforms:  Q96LC7-1   Q96LC7-2   Q96LC7-3   Q96LC7-4   Q96LC7-5   Q96LC7-6   Q96LC7-7   Q96LC7-8   
Q96LC7-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIGLEC10: NX_Q96LC7

Explore proteomics data for SIGLEC10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation of Tyr-667 is involved in binding to PTPN6
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LC7

  • SIGLEC10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIGLEC10 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001164627.1  NP_001164628.1  NP_001164629.1  NP_001164630.1  NP_001164632.1  NP_149121.2  

    ENSEMBL proteins: 
     ENSP00000408387   ENSP00000342389   ENSP00000395475   ENSP00000431444   ENSP00000414324  
     ENSP00000389132   ENSP00000345243   ENSP00000435281   ENSP00000433838   ENSP00000396742  
     ENSP00000348646  

    Human Recombinant Protein Products for SIGLEC10: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SIGLEC10
    OriGene Custom MassSpec 
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    Novus Biologicals SIGLEC10 Protein
    Novus Biologicals SIGLEC10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIGLEC10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    SIGLEC10 for ontologies           About GeneDecksing



    SIGLEC10 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96LC7

    ProtoNet protein and cluster: Q96LC7

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7
    Domain: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind
    the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIGLEC10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIG10_HUMAN, Q96LC7
    Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to
    alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions
    with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand
    induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block
    signal transduction through dephosphorylation of signaling molecules

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SIGLEC10 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Siglecg):
     cellular  hematopoietic system  immune system 

    SIGLEC10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Siglecgtm1Lnit for SIGLEC10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIGLEC10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIGLEC10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIGLEC10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIGLEC10 

    miRNA
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIGLEC10
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): SIGLEC10 (NM_033130)
    Sino Biological Human cDNA Clone for SIGLEC10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGLEC10
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    Sirion Biotech Customized lentivirus for stable overexpression of SIGLEC10 
                         Customized lentivirus expression plasmids for stable overexpression of SIGLEC10 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC10

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SIGLEC10 (Q96LC72, 3 ENSP000003452434) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293502, 3, ENSP000003915924MINT-8037943 I2D: score=3 STRING: ENSP00000391592
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    CD24P250633I2D: score=1 
    CMASENSP000002293294STRING: ENSP00000229329
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    SIGLEC10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIGLEC10 (SIG10)

    Search CenterWatch for drugs/clinical trials and news about SIGLEC10 / SIG10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIGLEC10 gene (7 alternative transcripts): 
    NM_001171160.1  NM_001171156.1  NM_001171157.1  NM_001171158.1  NM_001171159.1  NM_001171161.1  NM_033130.4  

    Unigene Cluster for SIGLEC10:

    Sialic acid binding Ig-like lectin 10
    Hs.284813  [show with all ESTs]
    Unigene Representative Sequence: NM_033130
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441969 ENST00000353836(uc002pwp.3 uc002pwo.3 uc021uyl.1 uc002pwq.3 uc010ycz.2 uc002pws.2 uc002pwr.3 uc010ycy.2)
    ENST00000442846 ENST00000357375(uc010eow.3) ENST00000525998 ENST00000436984
    ENST00000439889 ENST00000339313 ENST00000529627 ENST00000530476 ENST00000524527
    ENST00000432469 ENST00000356298
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC10

    Additional mRNA sequence: 

    AF310233.1 AF311905.1 AK122619.1 AK289900.1 AK290542.1 AK292025.1 AK294185.1 AK303514.1 
    AK303717.1 AY032685.1 AY358337.1 BC009955.2 BC101725.1 BC143497.1 BC143500.1 

    10 DOTS entries:

    DT.97776255  DT.97826694  DT.97766562  DT.100020416  DT.101981076  DT.121495563  DT.75124112  DT.102822051 
    DT.92059427  DT.95096582 

    21 AceView cDNA sequences:

    BQ711946 BQ002183 BX283650 BC009955 AF311905 AA321342 BP360053 AY032685 
    NM_033130 AF310233 AY358337 BM972768 AK122619 BX470328 AF301007 AI863808 
    AA361770 AI880327 BF663289 AI918403 BI912042 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                  -     -                             -     -         
    SP2:                                                  -                                   -               
    SP3:                          -     -     -     -     -                                                   
    SP4:                                                  -     -                                             
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for SIGLEC10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIGLEC10 expression in normal human tissues (normalized intensities)      SIGLEC10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAACATCAG
    SIGLEC10 Expression
    About this image


    SIGLEC10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             neutrophils   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See SIGLEC10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIGLEC10

    SOURCE GeneReport for Unigene cluster: Hs.284813

    UniProtKB/Swiss-Prot: SIG10_HUMAN, Q96LC7
    Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell
    subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and
    appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal
    chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells

        SABiosciences Custom PCR Arrays for SIGLEC10
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIGLEC10 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglecg1 , 5 sialic acid binding Ig-like lectin G1, 5 72.13(n)1
    61.2(a)1
      7 (28.25 cM)5
    2439581  NM_172900.31  NP_766488.21 
     434082045 


    ENSEMBL Gene Tree for SIGLEC10 (if available)
    TreeFam Gene Tree for SIGLEC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIGLEC10 gene
    CD332  SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  
    MAG2  SIGLEC72  SIGLEC92  
    13 SIMAP similar genes for SIGLEC10 using alignment to 6 protein entries:     SIG10_HUMAN (see all proteins):
    SIGLEC16    SIGLEC11    CD33    SIGLECL1    SIGLEC14    SIGLEC12
    SIGLEC6    SIGLEC7    CEA    SIGLEC8    PSG11    SIGLEC5
    SIGLEC9

    SIGLEC10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SIGLEC10
    PGOHUM00000258105


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 SNPs in SIGLEC10 are shown (see all 339)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753558701,2
    Cuntested156279254(+) CCTGTC/G/TGGGGG 12 Q R mis10--------
    rs1385868541,2
    --48244738(+) CAAGCC/GATCCA 6 -- int10--------
    rs1493883221,2
    --48244759(+) CCTCCC/TAAAGT 6 -- int10--------
    rs1828584001,2
    --48244883(+) GTGTCA/GAAGGC 6 -- int10--------
    rs1474799911,2
    --48244961(+) GTTCCA/GAATGC 6 -- int10--------
    rs1871840901,2
    --48245014(+) TTTTTC/TGAGAC 6 -- int10--------
    rs1915888101,2
    --48245211(+) CGAGGC/TGGTAA 6 -- int10--------
    rs1438602901,2
    --48245222(+) GGTGAA/GAGCAA 6 -- ut310--------
    rs1837420991,2
    --48245281(+) GAGCAA/GCGCCT 6 -- ut310--------
    rs735621461,2
    C,F--48245283(+) GCAGCG/TCCTAG 6 -- ut315Minor allele frequency- T:0.22WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for SIGLEC10 (51913275 - 51921057 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIGLEC10: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC10
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606091    OMIM disorders: --

    7 diseases for SIGLEC10:    About MalaCards
    non-invasive bladder papillary urothelial neoplasm    mucocele of salivary gland    chronic leukemia    hepatitis b
    lymphoblastic leukemia    hepatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for SIGLEC10:
    Mucocele of salivary gland

    SIGLEC10 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SIGLEC10 (1 document)

    Export disorders for SIGLEC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIGLEC10 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SIGLEC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor. (PubMed id 11284738)1, 2, 3 Munday J.... Crocker P.R. (2001)
    2. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PubMed id 11409878)1, 2, 9 Yousef G.M.... Diamandis E.P. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. (PubMed id 12163025)1, 2 Kitzig F.... Sayos J. (2002)
    6. Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. (PubMed id 11358961)1, 2 Li N.... Cao X. (2001)
    7. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    8. Human Siglec-10 can bind to vascular adhesion protein -1 and serves as its substrate. (PubMed id 19861682)1 Kivi E....Jalkanen S. (2009)
    9. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89790 HGNC: 15620 AceView: SIGLEC10 Ensembl:ENSG00000142512 euGenes: HUgn89790
    ECgene: SIGLEC10 H-InvDB: SIGLEC10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIGLEC10 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_00002
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_268

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIGLEC10 gene:
    Search GeneIP for patents involving SIGLEC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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