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Aliases for SIGLEC10 Gene

Aliases for SIGLEC10 Gene

  • Sialic Acid Binding Ig Like Lectin 10 2 3 5
  • Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7 2 3
  • Siglec-Like Protein 2 3 4
  • Siglec-Like Gene 2 2 3
  • SIGLEC-10 3 4
  • SLG2 3 4
  • Sialic Acid Binding Ig-Like Lectin 10 2
  • Sialic Acid-Binding Ig-Like Lectin 10 3
  • PRO940 3

External Ids for SIGLEC10 Gene

Previous GeneCards Identifiers for SIGLEC10 Gene

  • GC19M052544
  • GC19M052275
  • GC19M056589
  • GC19M056606
  • GC19M056607
  • GC19M056608
  • GC19M051915
  • GC19M051916

Summaries for SIGLEC10 Gene

Entrez Gene Summary for SIGLEC10 Gene

  • SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

GeneCards Summary for SIGLEC10 Gene

SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include Stargardt Disease. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.

UniProtKB/Swiss-Prot for SIGLEC10 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene Wiki entry for SIGLEC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC10 Gene

Genomics for SIGLEC10 Gene

Regulatory Elements for SIGLEC10 Gene

Enhancers for SIGLEC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051735 1.3 FANTOM5 Ensembl ENCODE 11.7 -318.3 -318298 1.4 SMARCE1 CTCF ATF1 TAL1 ZMYM3 ZNF175 CEBPB ARID1B JUND NCOR1 FPR1 FPR2 SIGLEC10 ZNF350 SIGLEC14 HAS1
GH19F051750 1.1 FANTOM5 ENCODE 11 -333.1 -333141 0.8 FPR1 FPR2 SIGLEC10 ZNF350 HAS1
GH19F051753 1.1 FANTOM5 Ensembl 10.9 -336.4 -336398 1.2 ZBTB40 FPR1 FPR2 HAS1 SIGLEC10 FPR3 RPL7P51 SIGLEC14 SIGLEC5 ZNF350 LOC105372448
GH19F051766 0.3 FANTOM5 10 -348.8 -348822 0.4 ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 ZNF143 FPR1 FPR2 SIGLEC10 ZNF350 SIGLEC14 LOC105372448
GH19F051620 1.4 FANTOM5 Ensembl ENCODE 9.2 -203.1 -203100 1.4 CTCF MTA2 MAX JUNB TBX21 EED IKZF1 PBX2 ETV6 MYC FPR2 FPR1 SIGLEC10 ZNF350 SIGLEC5 RPL9P33 PIR37863
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Promoters for SIGLEC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818635 703 201 MTA2 NRF1 JUNB UBTF JUND POLR2A EED IKZF1 TCF7 CREM

Genomic Location for SIGLEC10 Gene

Chromosome:
19
Start:
51,410,021 bp from pter
End:
51,417,803 bp from pter
Size:
7,783 bases
Orientation:
Minus strand

Genomic View for SIGLEC10 Gene

Genes around SIGLEC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC10 Gene

Proteins for SIGLEC10 Gene

  • Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC7-SIG10_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 10
    Protein Accession:
    Q96LC7
    Secondary Accessions:
    • A8K1I5
    • A8K3C7
    • C9JJ33
    • C9JM10
    • F8W917
    • Q3MIR5
    • Q6UXI8
    • Q96G54
    • Q96LC8

    Protein attributes for SIGLEC10 Gene

    Size:
    697 amino acids
    Molecular mass:
    76592 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.

    Alternative splice isoforms for SIGLEC10 Gene

neXtProt entry for SIGLEC10 Gene

Post-translational modifications for SIGLEC10 Gene

  • Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Glycosylation at Asn 100, Asn 355, Asn 364, Asn 486, and Asn 504
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SIGLEC10 Gene

Domains & Families for SIGLEC10 Gene

Suggested Antigen Peptide Sequences for SIGLEC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LC7

UniProtKB/Swiss-Prot:

SIG10_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC10: view

Function for SIGLEC10 Gene

Molecular function for SIGLEC10 Gene

UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Gene Ontology (GO) - Molecular Function for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view
genes like me logo Genes that share phenotypes with SIGLEC10: view

Animal Models for SIGLEC10 Gene

MGI Knock Outs for SIGLEC10:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGLEC10

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGLEC10 Gene

Localization for SIGLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC10 Gene COMPARTMENTS Subcellular localization image for SIGLEC10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 2
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Pathways & Interactions for SIGLEC10 Gene

genes like me logo Genes that share pathways with SIGLEC10: view

Pathways by source for SIGLEC10 Gene

SIGNOR curated interactions for SIGLEC10 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Transcripts for SIGLEC10 Gene

Unigene Clusters for SIGLEC10 Gene

Sialic acid binding Ig-like lectin 10:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SIGLEC10 Gene

GeneLoc Exon Structure for
SIGLEC10
ECgene alternative splicing isoforms for
SIGLEC10

Expression for SIGLEC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIGLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene

This gene is overexpressed in Whole Blood (x21.9) and Spleen (x8.0).

Protein differential expression in normal tissues from HIPED for SIGLEC10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (37.7), Monocytes (20.7), and Blymphocyte (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIGLEC10 Gene



Protein tissue co-expression partners for SIGLEC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC10 Gene:

SIGLEC10

SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene:

Hs.284813

mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene:

Q96LC7-SIG10_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
genes like me logo Genes that share expression patterns with SIGLEC10: view

Primer Products

Orthologs for SIGLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC10 34 35
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia SIGLEC10 34
  • 76.38 (n)
-- 35
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SIGLEC10 34
  • 75.71 (n)
-- 35
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Siglec10 34
  • 74.5 (n)
mouse
(Mus musculus)
Mammalia Siglecg 34 16 35
  • 72.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732062 34
  • 47.09 (n)
Species where no ortholog for SIGLEC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC10 Gene

ENSEMBL:
Gene Tree for SIGLEC10 (if available)
TreeFam:
Gene Tree for SIGLEC10 (if available)

Paralogs for SIGLEC10 Gene

Pseudogenes.org Pseudogenes for SIGLEC10 Gene

genes like me logo Genes that share paralogs with SIGLEC10: view

Variants for SIGLEC10 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1010425 -- 51,417,359(+) CAGTC(C/T)TGTCG reference, synonymous-codon, utr-variant-3-prime
rs111320201 -- 51,419,479(+) GCTCA(C/T)TGCAA upstream-variant-2KB
rs111865145 -- 51,416,640(+) TGCAC(A/G)CCCCA intron-variant, reference, missense
rs111875734 -- 51,413,688(+) AAAAG(C/T)GGAAG intron-variant
rs111911042 -- 51,416,297(+) CCCGA(A/C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC10 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for SIGLEC10 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGLEC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Disorders for SIGLEC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGLEC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
stargardt disease
  • stargardt disease 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIGLEC10

Human Genome Epidemiology (HuGE) Navigator
SIGLEC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC10
genes like me logo Genes that share disorders with SIGLEC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC10 Gene

Publications for SIGLEC10 Gene

  1. Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J. … Crocker P.R. (Biochem. J. 2001) 2 3 4 64
  2. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef G.M. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. (PMID: 12163025) Kitzig F. … Sayos J. (Biochem. Biophys. Res. Commun. 2002) 3 4 64

Products for SIGLEC10 Gene

Sources for SIGLEC10 Gene

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