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Aliases for SIGLEC10 Gene

Aliases for SIGLEC10 Gene

  • Sialic Acid Binding Ig-Like Lectin 10 2 3
  • Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7 2 3
  • Siglec-Like Protein 2 3 4
  • Siglec-Like Gene 2 2 3
  • SIGLEC-10 3 4
  • SLG2 3 4
  • Sialic Acid-Binding Ig-Like Lectin 10 3
  • PRO940 3

External Ids for SIGLEC10 Gene

Summaries for SIGLEC10 Gene

Entrez Gene Summary for SIGLEC10 Gene

  • SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]

GeneCards Summary for SIGLEC10 Gene

SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include mucocele of salivary gland. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for SIGLEC10 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules

Gene Wiki entry for SIGLEC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC10 Gene

Genomics for SIGLEC10 Gene

Genomic Location for SIGLEC10 Gene

Start:
51,410,021 bp from pter
End:
51,417,803 bp from pter
Size:
7,783 bases
Orientation:
Minus strand

Genomic View for SIGLEC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC10 Gene

Regulatory Elements for SIGLEC10 Gene

Proteins for SIGLEC10 Gene

  • Protein details for SIGLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LC7-SIG10_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 10
    Protein Accession:
    Q96LC7
    Secondary Accessions:
    • A8K1I5
    • A8K3C7
    • C9JJ33
    • C9JM10
    • F8W917
    • Q3MIR5
    • Q6UXI8
    • Q96G54
    • Q96LC8

    Protein attributes for SIGLEC10 Gene

    Size:
    697 amino acids
    Molecular mass:
    76592 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 upon phosphorylation.

    Alternative splice isoforms for SIGLEC10 Gene

neXtProt entry for SIGLEC10 Gene

Proteomics data for SIGLEC10 Gene at MOPED

Post-translational modifications for SIGLEC10 Gene

  • Phosphorylation of Tyr-667 is involved in binding to PTPN6.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn100, Asn355, Asn364, Asn486, and Asn504

No data available for DME Specific Peptides for SIGLEC10 Gene

Domains for SIGLEC10 Gene

Gene Families for SIGLEC10 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

UniProtKB/Swiss-Prot:

SIG10_HUMAN
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases:
    • Q96LC7
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q96LC7
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q96LC7
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • Q96LC7
genes like me logo Genes that share domains with SIGLEC10: view

Function for SIGLEC10 Gene

Molecular function for SIGLEC10 Gene

UniProtKB/Swiss-Prot Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules

Gene Ontology (GO) - Molecular Function for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Phenotypes for SIGLEC10 Gene

genes like me logo Genes that share phenotypes with SIGLEC10: view

Animal Models for SIGLEC10 Gene

MGI Knock Outs for SIGLEC10:

miRNA for SIGLEC10 Gene

miRTarBase miRNAs that target SIGLEC10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIGLEC10 Gene

Localization for SIGLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 4: Cell membrane; Single-pass type I membrane protein.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC10 Gene COMPARTMENTS Subcellular localization image for SIGLEC10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
cytosol 3
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

Pathways for SIGLEC10 Gene

SuperPathways for SIGLEC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIGLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SIGLEC10: view

No data available for Pathways by source for SIGLEC10 Gene

Transcripts for SIGLEC10 Gene

Unigene Clusters for SIGLEC10 Gene

Sialic acid binding Ig-like lectin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SIGLEC10 Gene

GeneLoc Exon Structure for
SIGLEC10
ECgene alternative splicing isoforms for
SIGLEC10

Expression for SIGLEC10 Gene

mRNA expression in normal human tissues for SIGLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC10 Gene

This gene is overexpressed in Whole Blood (21.9) and Spleen (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIGLEC10 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC10 Gene Hs.284813

mRNA Expression by UniProt/SwissProt for SIGLEC10 Gene

Q96LC7-SIG10_HUMAN
Tissue specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells
genes like me logo Genes that share expressions with SIGLEC10: view

Orthologs for SIGLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC10 36
  • 98.76 (n)
  • 98.28 (a)
SIGLEC10 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 63 (a)
OneToMany
SIGLEC10 36
  • 75.71 (n)
  • 64.44 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 58 (a)
OneToMany
SIGLEC10 36
  • 76.38 (n)
  • 65.24 (a)
mouse
(Mus musculus)
Mammalia Siglecg 36
  • 72.44 (n)
  • 61.6 (a)
Siglecg 16
Siglecg 37
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Siglec10 36
  • 74.5 (n)
  • 64.02 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732062 36
  • 47.09 (n)
  • 41.28 (a)
Species with no ortholog for SIGLEC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC10 Gene

ENSEMBL:
Gene Tree for SIGLEC10 (if available)
TreeFam:
Gene Tree for SIGLEC10 (if available)

Paralogs for SIGLEC10 Gene

Pseudogenes.org Pseudogenes for SIGLEC10 Gene

genes like me logo Genes that share paralogs with SIGLEC10: view

Variants for SIGLEC10 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1833786 -- 51,418,250(+) CCCAG(A/C/G)CTGCA upstream-variant-2KB
rs1833787 -- 51,418,352(+) CACGC(A/G)CCACC upstream-variant-2KB
rs4801865 -- 51,419,540(+) ctggg(A/G)ctaca upstream-variant-2KB
rs4802794 -- 51,419,415(+) ttTTG(G/T)ttttt upstream-variant-2KB
rs6509535 -- 51,412,699(+) ttaaa(A/C)ttttg intron-variant

Relevant External Links for SIGLEC10 Gene

HapMap Linkage Disequilibrium report
SIGLEC10

No data available for Structural Variations from Database of Genomic Variants (DGV) for SIGLEC10 Gene

Disorders for SIGLEC10 Gene

(1) MalaCards Diseases for SIGLEC10 Gene

Search for SIGLEC10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SIGLEC10 Gene

Relevant External Links for SIGLEC10

Human Genome Epidemiology (HuGE) Navigator
SIGLEC10
genes like me logo Genes that share disorders with SIGLEC10: view

No data available for UniProtKB/Swiss-Prot for SIGLEC10 Gene

Publications for SIGLEC10 Gene

  1. Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants. (PMID: 11409878) Yousef G.M. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Identification, characterization and leucocyte expression of Siglec- 10, a novel human sialic acid-binding receptor. (PMID: 11284738) Munday J. … Crocker P.R. (Biochem. J. 2001) 2 3 4
  3. Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. (PMID: 11358961) Li N. … Cao X. (J. Biol. Chem. 2001) 3 4
  4. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. (PMID: 12163025) Kitzig F. … Sayos J. (Biochem. Biophys. Res. Commun. 2002) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for SIGLEC10 Gene

Sources for SIGLEC10 Gene

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