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SIGLEC1 Gene

protein-coding   GIFtS: 55
GCID: GC20M003667

Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin

(Previous name: sialoadhesin)
(Previous symbol: SN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin1 2     SIGLEC-12
SN1 2 3 5     dJ1009E24.12
sialoadhesin1 2     Sialic Acid-Binding Immunoglobulin-Like Lectin 12
Sialic Acid-Binding Ig-Like Lectin 12 3     Siglec-13
CD1692     CD169 Antigen3

External Ids:    HGNC: 111271   Entrez Gene: 66142   Ensembl: ENSG000000888277   OMIM: 6007515   UniProtKB: Q9BZZ23   

Export aliases for SIGLEC1 gene to outside databases

Previous GC identifer: GC20M003616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIGLEC1 Gene:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion
molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I
transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell
interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than
membrane-bound; however, the full-length nature of this variant has not been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for SIGLEC1 Gene:
SIGLEC1 (sialic acid binding Ig-like lectin 1, sialoadhesin) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is VCAM1.

UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2
Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion
molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural
killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIGLEC1 gene promoter:
         TBP   p300   Hand1   IRF-1   POU3F2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIGLEC1 promoter sequence
   Search Chromatin IP Primers for SIGLEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIGLEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SIGLEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGLEC1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003667:  view genomic region     (about GC identifiers)

Start:
3,667,617 bp from pter      End:
3,687,775 bp from pter
Size:
20,159 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2 (See protein sequence)
Recommended Name: Sialoadhesin precursor  
Size: 1709 amino acids; 182624 Da
Secondary accessions: Q96DL4 Q9GZS5 Q9H1H6 Q9H1H7 Q9H7L7
Alternative splicing: 3 isoforms:  Q9BZZ2-1   Q9BZZ2-2   Q9BZZ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIGLEC1: NX_Q9BZZ2

Explore proteomics data for SIGLEC1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn159, Asn265, Asn339, Asn499, Asn697, Asn726, Asn730, Asn741, Asn886, Asn1104,
                                 Asn1138, Asn1251, Asn1462, Asn1476
  • Modification sites at PhosphoSitePlus

  • See SIGLEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075556.1  
    ENSEMBL proteins: 
     ENSP00000395778   ENSP00000341141   ENSP00000202578  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR013162 CD80_C2-set
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9BZZ2

    ProtoNet protein and cluster: Q9BZZ2

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 16 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with SIGLEC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SN_HUMAN, Q9BZZ2
    Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion
    molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural
    killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
    Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding NAS11133773
         
    Find genes that share ontologies with SIGLEC1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Siglec1):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with SIGLEC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SIGLEC1: Siglec1tm1Croc Siglec1tm1(HBEGF)Mtka

       genOway: Develop your customized and physiologically relevant rodent model for SIGLEC1

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    hsa-miR-623 hsa-miR-548am hsa-miR-3607-5p hsa-miR-2278 hsa-miR-133b hsa-miR-3605-5p hsa-miR-221* hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSIGLEC1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SN_HUMAN, Q9BZZ2: Isoform 1: Cell membrane; Single-pass type I membrane protein
    SN_HUMAN, Q9BZZ2: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane NAS11133773

    Find genes that share ontologies with SIGLEC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIGLEC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with SIGLEC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SIGLEC1):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Array including SIGLEC1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SIGLEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SIGLEC1 (Q9BZZ23 ENSP000003411414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNRQ927523, ENSP000002635254I2D: score=1 STRING: ENSP00000263525
    SPNP161503, ENSP000003532384I2D: score=2 STRING: ENSP00000353238
    MRC1P228973I2D: score=1 
    SELPLGQ142423I2D: score=1 
    MUC1ENSP000003389834STRING: ENSP00000338983
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0006954inflammatory response NAS11133773
    GO:0007160cell-matrix adhesion NAS11133773
    GO:0016337cell-cell adhesion NAS11133773
    GO:0070234positive regulation of T cell apoptotic process IEA--

    Find genes that share ontologies with SIGLEC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SIGLEC1 (SN)

    2 DrugBank Compounds for SIGLEC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Beta-D-Glucose-- 50-99-7target--10592235
    O-Sialic Acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for SIGLEC1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gq1balpha 84.5 1 9668345 (1)
    sialyllactose 83.4 3 15282752 (1), 9660955 (1), 14698884 (1)
    sialic acid 82.6 49 9874234 (4), 7592823 (3), 11133773 (3), 10577497 (3) (see all 22)
    n-glycolylneuraminic acid 61.1 1 9738906 (1)
    polysaccharide 47.7 9 9874234 (2), 7533044 (2), 7592823 (1), 14698884 (1) (see all 6)
    mannose 6-phosphate 38 2 11092246 (1), 10508773 (1)
    mannose 37.5 3 1317711 (1), 11092246 (1)
    monosaccharide 35 2 9874234 (2)
    n-acetylglucosamine 25.2 2 9874234 (2)
    galactose 23.9 3 9874234 (2), 14698884 (1)



    Find genes that share compounds with SIGLEC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIGLEC1 gene: 
    NM_023068.3  

    Unigene Cluster for SIGLEC1:

    Sialic acid binding Ig-like lectin 1, sialoadhesin
    Hs.31869  [show with all ESTs]
    Unigene Representative Sequence: NM_023068
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419548(uc002wjb.1) ENST00000344754(uc002wja.3 uc002wiz.4)
    ENST00000202578(uc002wjc.3)
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    hsa-miR-623 hsa-miR-548am hsa-miR-3607-5p hsa-miR-2278 hsa-miR-133b hsa-miR-3605-5p hsa-miR-221* hsa-miR-133a
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    Additional mRNA sequence: 

    AF230073.1 AK024459.1 AK024462.1 AK024479.1 AK057560.1 AL833688.1 AY927519.1 BC141884.1 

    5 DOTS entries:

    DT.313873  DT.97838194  DT.101970481  DT.100780463  DT.95229479 

    Selected AceView cDNA sequences (see all 77):

    BU617129 AK024462 AI375186 AA429482 BM974118 AA402775 AK057560 AA366176 
    H39702 AI032935 AA478009 AL833688 AA009785 NM_023068 AF230073 BX281374 
    BE857558 AA977133 AA486735 AI804201 BQ772131 BQ016363 BM695571 AI936668 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                            -                                                                                                           -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                        -   

    ExUns: 20 ^ 21a · 21b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:  -               


    ECgene alternative splicing isoforms for SIGLEC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIGLEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCATTGCC
    SIGLEC1 Expression
    About this image


    SIGLEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SIGLEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIGLEC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.31869

    UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2
    Tissue specificity: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node,
    perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of
    colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis

        Pathway & Disease-focused RT2 Profiler PCR Array including SIGLEC1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIGLEC1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siglec11 , 5 sialic acid binding Ig-like lectin 1, sialoadhesin1, 5 77.74(n)1
    73.41(a)1
      2 (63.26 cM)5
    206121  NM_011426.31  NP_035556.31 
     1310692205 
    chicken
    (Gallus gallus)
    Aves SIGLEC16
    sialic acid binding Ig-like lectin 1, sialoadhesin...
    36(a)
    1 ↔ 1
    AADN03017184.1(1012-5624)
    lizard
    (Anolis carolinensis)
    Reptilia SIGLEC16
    sialic acid binding Ig-like lectin 1, sialoadhesin...
    36(a)
    1 ↔ 1
    GL343738.1(66007-112069)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia siglec11 sialic acid binding Ig-like lectin 1, sialoadhesin 48.79(n)
    37.37(a)
      100486430  XM_002938400.2  XP_002938446.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01058865.16
    si:dkey-27j5.106
    (see all 3)
    si:dkey-27j5.10
    (see all 3)
    23(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(58093921-58105044) ENSDARG00000034098
    1(57782269-57810365) ENSDARG00000094157


    ENSEMBL Gene Tree for SIGLEC1 (if available)
    TreeFam Gene Tree for SIGLEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIGLEC1 gene
    VCAM12  CD222  
    2 SIMAP similar genes for SIGLEC1 using alignment to 3 protein entries:     SN_HUMAN (see all proteins):
    FLJ00411    FCGR2B

    Find genes that share paralogs with SIGLEC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIGLEC1 (see all 830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898749461,2
    --3667134(+) GTCCCC/TTTGGA 1 -- ds50010--------
    rs1415173281,2
    --3667158(+) AGGTGA/GAGACT 1 -- ds50010--------
    rs1806786511,2
    --3667190(+) TCCCCC/TCAGTA 1 -- ds50010--------
    rs5288631,2
    C,F,A,H--3667198(-) GCTGCA/GGCTAC 1 -- ds500110Minor allele frequency- G:0.35MN NA WA CSA EA 554
    rs1461917891,2
    --3667219(+) GCTTAC/TGGTCC 1 -- ds50010--------
    rs1391988671,2
    C--3667395(+) TGCACA/GGGGCT 1 -- ds50010--------
    rs780565971,2
    C,F--3667406(+) GGTCAT/CTGTGG 1 -- ds50012Minor allele frequency- C:0.12CSA WA 120
    rs1875639751,2
    --3667433(+) ACACAC/TGAAGC 1 -- ds50010--------
    rs1499150101,2
    --3667471(+) ACTTCA/GGCGTA 1 -- ds50010--------
    rs1918457331,2
    C--3667473(+) TTCAGC/TGTAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SIGLEC1 (3667617 - 3687775 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SIGLEC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4521n71CNV Loss21882294
    nsv470536CNV Loss18288195
    nsv520565CNV Loss19592680
    nsv912615CNV Loss21882294
    nsv912616CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIGLEC1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIGLEC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600751    OMIM disorders: --


    Find genes that share disorders with SIGLEC1           About GenesLikeMe

    2 Novoseek inferred disease relationships for SIGLEC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kaposi sarcoma 17.4 1 17330143 (1)
    inflammation 0 3 18414664 (1), 8913692 (1), 15579285 (1)

    Genetic Association Database (GAD): SIGLEC1
    Human Genome Epidemiology (HuGE) Navigator: SIGLEC1 (2 documents)

    Export disorders for SIGLEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIGLEC1 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with SIGLEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33. (PubMed id 8530048)1, 3, 9 Mucklow S....Crocker P.R. (Genomics 1995)
    2. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. (PubMed id 11133773)1, 2, 9 Hartnell A....Crocker P.R. (Blood 2001)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    7. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. (PubMed id 18414664)1, 9 Rempel H....Pulliam L. (PLoS ONE 2008)
    8. Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression. (PubMed id 17330143)1, 9 van der Kuyl A.C....Cornelissen M. (PLoS ONE 2007)
    9. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. (PubMed id 19950173)1, 9 Seyerl M....StAPckl J. (Eur. J. Immunol. 2010)
    10. Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. (PubMed id 16002716)1, 9 Kirchberger S....StAPckl J. (J. Immunol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6614 HGNC: 11127 AceView: SN Ensembl:ENSG00000088827 euGenes: HUgn6614
    ECgene: SIGLEC1 Kegg: 6614 H-InvDB: SIGLEC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIGLEC1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_267

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIGLEC1 gene:
    Search GeneIP for patents involving SIGLEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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