SIGLEC1 Gene
protein-coding GIFtS: 52
GCID: GC20M003667
|
|
sialic acid binding Ig-like lectin 1, sialoadhesin(Previous name: sialoadhesin )
(Previous symbol: SN)
| |
Aliases
for SIGLEC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin1 2 | | FLJ000511 | | SN1 2 3 5 | | FLJ000551 | | CD1691 2 | | FLJ000731 | | SIGLEC-11 2 | | FLJ321501 | | DJ1009E24.11 | | Sialic Acid-Binding Immunoglobulin-Like Lectin 12 | | Sialoadhesin1 | | Siglec-13 | | Sialic Acid-Binding Ig-Like Lectin 12 3 | | CD169 Antigen3 |
Export aliases for SIGLEC1 gene to outside databasesPrevious GC identifer: GC20M003616 |
Summaries
for SIGLEC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIGLEC1:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion moleculethat binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembraneprotein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions.Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound;however, the full-length nature of this variant has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesionmolecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killercells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds toSPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis
|
Genomic Views
for SIGLEC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIGLEC1 gene promoter:
TBP p300 Hand1 IRF-1 POU3F2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIGLEC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13SIGLEC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M003667: view genomic region
(about GC identifiers)
Start:
|
3,667,617 bp from pter |
End:
|
3,687,775 bp from pter |
Size:
|
20,159 bases |
Orientation:
|
minus strand |
|
Proteins
for SIGLEC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2 (See
protein sequence)Recommended Name: Sialoadhesin precursor Size: 1709 amino acids; 182624 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: Q96DL4 Q9GZS5 Q9H1H6 Q9H1H7 Q9H7L7Alternative splicing: 3 isoforms: Q9BZZ2-1 Q9BZZ2-2 Q9BZZ2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIGLEC1: NX_Q9BZZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZZ2
SIGLEC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075556.1
ENSEMBL proteins: ENSP00000341141 ENSP00000395778 ENSP00000202578
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SIGLEC1 for ontologies About GeneDecksing
SIGLEC1 Antibody Products:
Assay Products for SIGLEC1: |
Protein
Domains /
Families
for SIGLEC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIGLEC1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BZZ2ProtoNet protein and cluster: Q9BZZ2 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) familySimilarity: Contains 16 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIGLEC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesionmolecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killercells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds toSPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIGLEC1 (NM_023068) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SIGLEC1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SIGLEC1: Siglec1tm1Croc Siglec1tm1(HBEGF)Mtka
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Siglec1):
SIGLEC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SIGLEC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion molecules (CAMs) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SIGLEC1):
SIGLEC1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIGLEC1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/7 Interacting proteins for SIGLEC1 (Q9BZZ23 ENSP000003411414) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SIGLEC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIGLEC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SIGLEC1 for compounds About GeneDecksing
 Browse Tocris compounds for SIGLEC1
2 DrugBank Compounds for SIGLEC1 About this table
10/15 Novoseek chemical compound relationships for SIGLEC1 gene (see all 15) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gq1balpha |
84.5 |
1 |
9668345 (1) |
| sialyllactose |
83.4 |
3 |
15282752 (1), 9660955 (1), 14698884 (1) |
| sialic acid |
82.6 |
49 |
9874234 (4), 7592823 (3), 11133773 (3), 10577497 (3) (see all 22) |
| n-glycolylneuraminic acid |
61.1 |
1 |
9738906 (1) |
| polysaccharide |
47.7 |
9 |
9874234 (2), 7533044 (2), 7592823 (1), 14698884 (1) (see all 6) |
| mannose 6-phosphate |
38 |
2 |
11092246 (1), 10508773 (1) |
| mannose |
37.5 |
3 |
1317711 (1), 11092246 (1) |
| monosaccharide |
35 |
2 |
9874234 (2) |
| n-acetylglucosamine |
25.2 |
2 |
9874234 (2) |
| galactose |
23.9 |
3 |
9874234 (2), 14698884 (1) |
Search CenterWatch for drugs/clinical trials and news about SIGLEC1 / SN
|
Transcripts
for SIGLEC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIGLEC1 gene: NM_023068.3 Unigene Cluster for SIGLEC1: Sialic acid binding Ig-like lectin 1, sialoadhesin Hs.31869 [show with all ESTs]Unigene Representative Sequence: NM_0230683 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344754(uc002wja.3 uc002wiz.4) ENST00000419548(uc002wjb.1)
ENST00000202578(uc002wjc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIGLEC1 (NM_023068) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIGLEC1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC1 |
Additional cDNA sequence: AF230073.1 AK024459.1 AK024462.1 AK024479.1 AK057560.1 AL833688.1 AY927519.1 BC141884.1 5 DOTS entries: DT.313873 DT.97838194 DT.101970481 DT.100780463 DT.95229479 24/77 AceView cDNA sequences (see all 77): AA366176 AA009785 NM_023068 H39702 AL833688 AK024462 AA402775 BM974118 AI375186 AA429482 AK057560 BU617129 AI032935 AF230073 AA478009 BX281374 BQ016363 AI347674 BQ006953 AA421808 BE857558 CD631737 AA402210 CB528718
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | |
| ExUns: | 20 | ^ | 21a | · | 21b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | - | | | | | |
ECgene alternative splicing isoforms for SIGLEC1
|
Expression
for SIGLEC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIGLEC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCATTGCC
About this image
See SIGLEC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIGLEC1
SOURCE GeneReport for Unigene cluster: Hs.31869
UniProtKB/Swiss-Prot: SN_HUMAN, Q9BZZ2Tissue specificity: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node,perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon andlung. Also expressed by inflammatory macrophages in rheumatoid arthritis
SABiosciences Expression via Pathway-Focused PCR Array including SIGLEC1: | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIGLEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC1 |
Orthologs
for SIGLEC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIGLEC1 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SIGLEC16 |
-- |
34(a) |
1 ↔ 1 |
GL343738.1(66007-112069) |
ENSEMBL Gene Tree for SIGLEC1 (if available)
TreeFam Gene Tree for SIGLEC1 (if available) |
Paralogs
for SIGLEC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIGLEC1 gene
- CD222
2 SIMAP similar genes for SIGLEC1 using alignment to 3 protein entries: SN_HUMAN (see all proteins):FLJ00411 FCGR2B
SIGLEC1 for paralogs About GeneDecksing
|
Genomic Variants
for SIGLEC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIGLEC1 (3667617 - 3687775 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIGLEC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC1 |
|
Disorders
/ Diseases
for SIGLEC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIGLEC1 for disorders About GeneDecksing
OMIM gene information: 600751
OMIM disorders: --
19  diseases for SIGLEC1: About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas kaposi's sarcoma primary biliary cirrhosis
proliferative glomerulonephritis systemic lupus erythematosus lupus erythematosus glomerulonephritis
sarcoma rheumatoid arthritis skin disease hepatitis b
hepatocellular carcinoma arthritis nephropathy breast cancer
hepatitis carcinoma neuronitis
2 Novoseek disease relationships for SIGLEC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| kaposi sarcoma |
17.4 |
1 |
17330143 (1) |
| inflammation |
0 |
3 |
18414664 (1), 8913692 (1), 15579285 (1) |
Human Genome Epidemiology (HuGE) Navigator: SIGLEC1 (2 documents)
Export disorders for SIGLEC1 gene to outside databases
|
Publications
for SIGLEC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIGLEC1 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with SIGLEC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33. (PubMed id 8530048)1, 3, 9 Mucklow S....Crocker P.R. (1995)
- Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. (PubMed id 11133773)1, 2, 9 Hartnell A....Crocker P.R. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
- Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. (PubMed id 18414664)1, 9 Rempel H....Pulliam L. (2008)
- Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression. (PubMed id 17330143)1, 9 van der Kuyl A.C....Cornelissen M. (2007)
- Human rhinoviruses induce IL-35-producing Treg via in duction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. (PubMed id 19950173)1, 9 Seyerl M....StAPckl J. (2010)
- Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. (PubMed id 16002716)1, 9 Kirchberger S....Stockl J. (2005)
- Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. (PubMed id 10610356)1, 9 Nath D....Crocker P.R. (1999)
|
External Searches for SIGLEC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIGLEC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIGLEC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIGLEC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIGLEC1 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_267 |
|
| | |
About This Section
| Patent Information for SIGLEC1 gene:
Search GeneIP for patents involving SIGLEC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIGLEC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIGLEC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGLEC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGLEC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIGLEC1 | | OriGene 3'-UTR Clone for SIGLEC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGLEC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIGLEC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIGLEC1 | | OriGene Custom Protein Services for SIGLEC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIGLEC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGLEC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGLEC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGLEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGLEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGLEC1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SIGLEC1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SIGLEC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGLEC1 |
|  |  |  | | | | ThermoFisher Antibodies for SIGLEC1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SIGLEC1 |
|
|
|
|
