Aliases for SIGLEC1 Gene
External Ids for SIGLEC1 Gene
Previous HGNC Symbols for SIGLEC1 Gene
Previous GeneCards Identifiers for SIGLEC1 Gene
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIGLEC1 Gene
SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Kaposi Sarcoma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immune System and Cell adhesion molecules (CAMs). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.
UniProtKB/Swiss-Prot for SIGLEC1 Gene
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.