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Aliases for SIGLEC1 Gene

Aliases for SIGLEC1 Gene

  • Sialic Acid Binding Ig Like Lectin 1 2 3
  • Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 1 3 4
  • SIGLEC-1 3 4
  • SN 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 1 3
  • CD169 Antigen 4
  • Sialoadhesin 2
  • DJ1009E24.1 3
  • CD169 3

External Ids for SIGLEC1 Gene

Previous HGNC Symbols for SIGLEC1 Gene

  • SN

Previous GeneCards Identifiers for SIGLEC1 Gene

  • GC20M003616

Summaries for SIGLEC1 Gene

Entrez Gene Summary for SIGLEC1 Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIGLEC1 Gene

SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Kaposi Sarcoma and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immune System and Cell adhesion molecules (CAMs). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.

UniProtKB/Swiss-Prot for SIGLEC1 Gene

  • Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC1 Gene

Genomics for SIGLEC1 Gene

Regulatory Elements for SIGLEC1 Gene

Enhancers for SIGLEC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIGLEC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGLEC1 Gene

Chromosome:
20
Start:
3,686,970 bp from pter
End:
3,712,617 bp from pter
Size:
25,648 bases
Orientation:
Minus strand

Genomic View for SIGLEC1 Gene

Genes around SIGLEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC1 Gene

Proteins for SIGLEC1 Gene

  • Protein details for SIGLEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZZ2-SN_HUMAN
    Recommended name:
    Sialoadhesin
    Protein Accession:
    Q9BZZ2
    Secondary Accessions:
    • Q96DL4
    • Q9GZS5
    • Q9H1H6
    • Q9H1H7
    • Q9H7L7

    Protein attributes for SIGLEC1 Gene

    Size:
    1709 amino acids
    Molecular mass:
    182624 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC1 Gene

Proteomics data for SIGLEC1 Gene at MOPED

Post-translational modifications for SIGLEC1 Gene

  • Glycosylation at Asn 159, Asn 265, Asn 339, Asn 499, Asn 697, Asn 726, Asn 730, Asn 741, Asn 886, Asn 1104, Asn 1138, Asn 1251, Asn 1462, and Asn 1476
  • Modification sites at PhosphoSitePlus

Other Protein References for SIGLEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SIGLEC1 (Siglec-1/CD169)

No data available for DME Specific Peptides for SIGLEC1 Gene

Domains & Families for SIGLEC1 Gene

Suggested Antigen Peptide Sequences for SIGLEC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZZ2

UniProtKB/Swiss-Prot:

SN_HUMAN :
  • Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC1: view

Function for SIGLEC1 Gene

Molecular function for SIGLEC1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
genes like me logo Genes that share phenotypes with SIGLEC1: view

Animal Models for SIGLEC1 Gene

MGI Knock Outs for SIGLEC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGLEC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SIGLEC1 Gene

Localization for SIGLEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC1 Gene COMPARTMENTS Subcellular localization image for SIGLEC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endosome 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SIGLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SIGLEC1: view

Pathways & Interactions for SIGLEC1 Gene

genes like me logo Genes that share pathways with SIGLEC1: view

Pathways by source for SIGLEC1 Gene

Interacting Proteins for SIGLEC1 Gene

Gene Ontology (GO) - Biological Process for SIGLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response NAS 11133773
genes like me logo Genes that share ontologies with SIGLEC1: view

No data available for SIGNOR curated interactions for SIGLEC1 Gene

Drugs & Compounds for SIGLEC1 Gene

(4) Drugs for SIGLEC1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0
O-Sialic Acid Experimental Pharma Target 0

(13) Additional Compounds for SIGLEC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIGLEC1: view

Transcripts for SIGLEC1 Gene

Unigene Clusters for SIGLEC1 Gene

Sialic acid binding Ig-like lectin 1, sialoadhesin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - -
SP2:
SP3:
SP4: -
SP5: -

ExUns: 20 ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for SIGLEC1 Gene

GeneLoc Exon Structure for
SIGLEC1
ECgene alternative splicing isoforms for
SIGLEC1

Expression for SIGLEC1 Gene

mRNA expression in normal human tissues for SIGLEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for SIGLEC1 Gene

This gene is overexpressed in Adrenal (35.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC1 Gene



SOURCE GeneReport for Unigene cluster for SIGLEC1 Gene Hs.31869

mRNA Expression by UniProt/SwissProt for SIGLEC1 Gene

Q9BZZ2-SN_HUMAN
Tissue specificity: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
genes like me logo Genes that share expression patterns with SIGLEC1: view

Primer Products

No data available for Protein tissue co-expression partners for SIGLEC1 Gene

Orthologs for SIGLEC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIGLEC1 35
  • 82.94 (n)
  • 79.95 (a)
SIGLEC1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIGLEC1 35
  • 82.65 (n)
  • 78.31 (a)
SIGLEC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siglec1 35
  • 77.74 (n)
  • 73.41 (a)
Siglec1 16
Siglec1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC1 35
  • 98.99 (n)
  • 98.71 (a)
SIGLEC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Siglec1 35
  • 70.89 (n)
  • 65.38 (a)
oppossum
(Monodelphis domestica)
Mammalia SIGLEC1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIGLEC1 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIGLEC1 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIGLEC1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siglec1 35
  • 48.79 (n)
  • 37.37 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01058865.1 36
  • 23 (a)
ManyToMany
si:ch211-1f22.14 36
  • 23 (a)
ManyToMany
si:dkey-27j5.10 36
  • 23 (a)
ManyToMany
Species with no ortholog for SIGLEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGLEC1 Gene

ENSEMBL:
Gene Tree for SIGLEC1 (if available)
TreeFam:
Gene Tree for SIGLEC1 (if available)

Paralogs for SIGLEC1 Gene

Paralogs for SIGLEC1 Gene

(2) SIMAP similar genes for SIGLEC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIGLEC1: view

Variants for SIGLEC1 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs625372 - 3,704,082(-) CCCCA(A/G)GGGTG reference, missense
rs709012 - 3,694,851(+) CTGTG(G/T)GTACC reference, missense
rs2853217 - 3,691,376(+) AGCAG(C/G)CCCAG reference, missense
rs3746638 - 3,694,686(+) TGGGT(A/G)CAGCT reference, missense
rs3746636 - 3,692,547(+) GACGG(G/T)AGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC1 Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
dgv4521n71 CNV Loss 21882294
nsv912615 CNV Loss 21882294
nsv912616 CNV Loss 21882294
nsv470536 CNV Loss 18288195

Variation tolerance for SIGLEC1 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIGLEC1 Gene

Disorders for SIGLEC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SIGLEC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • human herpesvirus 8
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIGLEC1

Genetic Association Database (GAD)
SIGLEC1
Human Genome Epidemiology (HuGE) Navigator
SIGLEC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGLEC1
genes like me logo Genes that share disorders with SIGLEC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGLEC1 Gene

Publications for SIGLEC1 Gene

  1. Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33. (PMID: 8530048) Mucklow S. … Crocker P.R. (Genomics 1995) 2 3 23 67
  2. Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. (PMID: 19950173) Seyerl M. … StAPckl J. (Eur. J. Immunol. 2010) 3 23
  3. Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. (PMID: 18383365) Biesen R. … GrA1tzkau A. (Arthritis Rheum. 2008) 3 23
  4. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. (PMID: 18414664) Rempel H. … Pulliam L. (PLoS ONE 2008) 3 23
  5. A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists. (PMID: 17328080) York M.R. … Lafyatis R. (Arthritis Rheum. 2007) 3 23

Products for SIGLEC1 Gene

Sources for SIGLEC1 Gene

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