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Aliases for SIGLEC1 Gene

Aliases for SIGLEC1 Gene

  • Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin 2 3
  • SN 3 4 6
  • Sialic Acid-Binding Ig-Like Lectin 1 3 4
  • Sialoadhesin 2 3
  • SIGLEC-1 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 1 3
  • CD169 Antigen 4
  • DJ1009E24.1 3
  • CD169 3

External Ids for SIGLEC1 Gene

Previous Symbols for SIGLEC1 Gene

  • SN

Summaries for SIGLEC1 Gene

Entrez Gene Summary for SIGLEC1 Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIGLEC1 Gene

SIGLEC1 (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.

UniProtKB/Swiss-Prot for SIGLEC1 Gene

  • Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC1 Gene

Genomics for SIGLEC1 Gene

Genomic Location for SIGLEC1 Gene

Start:
3,686,970 bp from pter
End:
3,712,566 bp from pter
Size:
25,597 bases
Orientation:
Minus strand

Genomic View for SIGLEC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGLEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC1 Gene

Regulatory Elements for SIGLEC1 Gene

Proteins for SIGLEC1 Gene

  • Protein details for SIGLEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZZ2-SN_HUMAN
    Recommended name:
    Sialoadhesin
    Protein Accession:
    Q9BZZ2
    Secondary Accessions:
    • Q96DL4
    • Q9GZS5
    • Q9H1H6
    • Q9H1H7
    • Q9H7L7

    Protein attributes for SIGLEC1 Gene

    Size:
    1709 amino acids
    Molecular mass:
    182624 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIGLEC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGLEC1 Gene

Proteomics data for SIGLEC1 Gene at MOPED

Post-translational modifications for SIGLEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn159, Asn265, Asn339, Asn499, Asn697, Asn726, Asn730, Asn741, Asn886, Asn1104, Asn1138, Asn1251, Asn1462, and Asn1476

Other Protein References for SIGLEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIGLEC1 Gene

Domains for SIGLEC1 Gene

Gene Families for SIGLEC1 Gene

HGNC:
  • CD :CD molecules
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins

Suggested Antigen Peptide Sequences for SIGLEC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZZ2

UniProtKB/Swiss-Prot:

SN_HUMAN
Domain:
  • Contains 16 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q9BZZ2
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9BZZ2
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.:
    • Q9BZZ2
genes like me logo Genes that share domains with SIGLEC1: view

Function for SIGLEC1 Gene

Molecular function for SIGLEC1 Gene

UniProtKB/Swiss-Prot Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

Gene Ontology (GO) - Molecular Function for SIGLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030246 carbohydrate binding NAS 11133773
genes like me logo Genes that share ontologies with SIGLEC1: view
genes like me logo Genes that share phenotypes with SIGLEC1: view

Animal Models for SIGLEC1 Gene

MGI Knock Outs for SIGLEC1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SIGLEC1 Gene

Localization for SIGLEC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGLEC1 Gene COMPARTMENTS Subcellular localization image for SIGLEC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIGLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane NAS 11133773
genes like me logo Genes that share ontologies with SIGLEC1: view

Pathways for SIGLEC1 Gene

SuperPathways for SIGLEC1 Gene

genes like me logo Genes that share pathways with SIGLEC1: view

Pathways by source for SIGLEC1 Gene

1 KEGG pathway for SIGLEC1 Gene

Interacting Proteins for SIGLEC1 Gene

Gene Ontology (GO) - Biological Process for SIGLEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006954 inflammatory response NAS 11133773
GO:0007160 cell-matrix adhesion NAS 11133773
GO:0016337 single organismal cell-cell adhesion NAS 11133773
GO:0070234 positive regulation of T cell apoptotic process IEA --
genes like me logo Genes that share ontologies with SIGLEC1: view

Compounds for SIGLEC1 Gene

(2) Drugbank Compounds for SIGLEC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-D-Glucose
50-99-7 target
O-Sialic Acid
target

(15) Novoseek inferred chemical compound relationships for SIGLEC1 Gene

Compound -log(P) Hits PubMed IDs
gq1balpha 84.5 1
sialyllactose 83.4 3
sialic acid 82.6 39
n-glycolylneuraminic acid 61.1 1
polysaccharide 47.7 8
genes like me logo Genes that share compounds with SIGLEC1: view

Transcripts for SIGLEC1 Gene

Unigene Clusters for SIGLEC1 Gene

Sialic acid binding Ig-like lectin 1, sialoadhesin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - -
SP2:
SP3:
SP4: -
SP5: -

ExUns: 20 ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for SIGLEC1 Gene

GeneLoc Exon Structure for
SIGLEC1
ECgene alternative splicing isoforms for
SIGLEC1

Expression for SIGLEC1 Gene

mRNA expression in normal human tissues for SIGLEC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SIGLEC1 Gene

SOURCE GeneReport for Unigene cluster for SIGLEC1 Gene Hs.31869

mRNA Expression by UniProt/SwissProt for SIGLEC1 Gene

Q9BZZ2-SN_HUMAN
Tissue specificity: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis
genes like me logo Genes that share expressions with SIGLEC1: view

Orthologs for SIGLEC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGLEC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGLEC1 35
  • 98.99 (n)
  • 98.71 (a)
SIGLEC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIGLEC1 35
  • 82.94 (n)
  • 79.95 (a)
SIGLEC1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIGLEC1 35
  • 82.65 (n)
  • 78.31 (a)
SIGLEC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siglec1 35
  • 77.74 (n)
  • 73.41 (a)
Siglec1 16
Siglec1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIGLEC1 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIGLEC1 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Siglec1 35
  • 70.89 (n)
  • 65.38 (a)
chicken
(Gallus gallus)
Aves SIGLEC1 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIGLEC1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siglec1 35
  • 48.79 (n)
  • 37.37 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01058865.1 36
  • 23 (a)
ManyToMany
si:ch211-1f22.14 36
  • 23 (a)
ManyToMany
si:dkey-27j5.10 36
  • 23 (a)
ManyToMany
Species with no ortholog for SIGLEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGLEC1 Gene

ENSEMBL:
Gene Tree for SIGLEC1 (if available)
TreeFam:
Gene Tree for SIGLEC1 (if available)

Paralogs for SIGLEC1 Gene

Paralogs for SIGLEC1 Gene

Selected SIMAP similar genes for SIGLEC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIGLEC1: view

Variants for SIGLEC1 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs13241 -- 3,687,143(-) GTGGG(A/G)AGTTG utr-variant-3-prime
rs488023 -- 3,700,989(-) gggcg(C/T)ggtgg intron-variant
rs501538 -- 3,696,710(-) GCTAA(A/G)GCTGA reference, synonymous-codon
rs525339 -- 3,696,367(-) TCACA(A/G)AGTGG intron-variant
rs527942 -- 3,696,141(-) TGTGT(G/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC1 Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
dgv4521n71 CNV Loss 21882294
nsv912615 CNV Loss 21882294
nsv912616 CNV Loss 21882294
nsv470536 CNV Loss 18288195

Relevant External Links for SIGLEC1 Gene

HapMap Linkage Disequilibrium report
SIGLEC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC1 Gene

Disorders for SIGLEC1 Gene

(2) Novoseek inferred disease relationships for SIGLEC1 Gene

Disease -log(P) Hits PubMed IDs
kaposi sarcoma 17.4 1
inflammation 0 3

Relevant External Links for SIGLEC1

Genetic Association Database (GAD)
SIGLEC1
Human Genome Epidemiology (HuGE) Navigator
SIGLEC1
genes like me logo Genes that share disorders with SIGLEC1: view

No data available for UniProtKB/Swiss-Prot for SIGLEC1 Gene

Publications for SIGLEC1 Gene

  1. Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33. (PMID: 8530048) Mucklow S. … Crocker P.R. (Genomics 1995) 2 3 23
  2. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. (PMID: 11133773) Hartnell A. … Crocker P.R. (Blood 2001) 3 4 23
  3. Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans. (PMID: 10406848) Zamze S. … Wing D.R. (Glycobiology 1999) 3 23
  4. Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. (PMID: 10610356) Nath D. … Crocker P.R. (Immunology 1999) 3 23
  5. Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. (PMID: 16002716) Kirchberger S. … StAPckl J. (J. Immunol. 2005) 3 23

Products for SIGLEC1 Gene

  • antibodies-online proteins for SIGLEC1
  • antibodies-online antibodies for SIGLEC1
  • antibodies-online kits for SIGLEC1

Sources for SIGLEC1 Gene

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