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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIGIRR Gene

protein-coding   GIFtS: 59
GCID: GC11M000395

Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain1 2     Toll/Interleukin-1 Receptor 82 3
Single Immunoglobulin Domain IL1R1 Related1 2     TIR82 3
Single Ig IL-1R-Related Molecule2 3     Single Ig IL-1-Related Receptor2
Single Immunoglobulin Domain-Containing IL1R-Related Protein2 3     

External Ids:    HGNC: 305751   Entrez Gene: 593072   Ensembl: ENSG000001851877   OMIM: 6054785   UniProtKB: Q6IA173   
ORGUL members:         
NONCODE14:n340928      

Export aliases for SIGIRR gene to outside databases

Previous GC identifers: GC11U990281 GC11P000782 GC11M000220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIGIRR Gene: 
SIGIRR (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SIGIRR include vaginitis, and chronic lymphocytic leukemia, and among its related super-pathways are TRAF Pathway. GO annotations related to this gene include transmembrane signaling receptor activity and protein binding.

UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the
recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain
interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and
IL1RAP

Gene Wiki entry for SIGIRR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIGIRR gene promoter:
         PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIGIRR promoter sequence
   Search SABiosciences Chromatin IP Primers for SIGIRR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGIRR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

SIGIRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIGIRR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000395:  view genomic region     (about GC identifiers)

Start:
405,716 bp from pter      End:
417,455 bp from pter
Size:
11,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17 (See protein sequence)
Recommended Name: Single Ig IL-1-related receptor  
Size: 410 amino acids; 45679 Da
Subunit: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at
least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least
composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3
Subcellular location: Membrane; Single-pass type III membrane protein (Potential)
Secondary accessions: Q3KQY2 Q6UXI3 Q9H733
Alternative splicing: 2 isoforms:  Q6IA17-1   Q6IA17-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIGIRR: NX_Q6IA17

Explore proteomics data for SIGIRR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IA17

  • SIGIRR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIGIRR Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001128525.1  NP_001128526.1  NP_068577.2  

    ENSEMBL proteins: 
     ENSP00000434164   ENSP00000433530   ENSP00000403104   ENSP00000380756   ENSP00000333656  
     ENSP00000433022   ENSP00000435135   ENSP00000434030   ENSP00000431698   ENSP00000371960  

    Human Recombinant Protein Products for SIGIRR: 
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    Novus Biologicals SIGIRR Proteins
    Novus Biologicals SIGIRR Lysates
    Sino Biological Recombinant Protein for SIGIRR
    Sino Biological Cell Lysate for SIGIRR 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIGIRR 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IMP10346978
    GO:0016021integral to membrane IEA--

    SIGIRR for ontologies           About GeneDecksing



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    Abcam antibodies for SIGIRR
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    LSBio Antibodies in human, mouse, rat for SIGIRR 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR015621 IL1-receptor_fam
     IPR007110 Ig-like_dom
     IPR000157 TIR_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6IA17

    ProtoNet protein and cluster: Q6IA17

    UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17
    Similarity: Belongs to the interleukin-1 receptor family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 TIR domain


    SIGIRR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIGIR_HUMAN, Q6IA17
    Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the
    recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain
    interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and
    IL1RAP
    Induction: Down-regulated during inflammation by inhibition of an SP1-mediated pathway

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12925853
         
    SIGIRR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SIGIRR:
     Decreased nuclei size in G2M  Lamellipodia and high actin ra 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sigirr):
     cellular  digestive/alimentary  hematopoietic system  immune system 

    SIGIRR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SIGIRR: Sigirrtm1Lix Sigirrtm1Lex Sigirrtm1Mant

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIGIRR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIGIRR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIGIRR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIGIRR 

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGIRR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SIGIRR
    SwitchGear 3'UTR luciferase reporter plasmidSIGIRR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector (see all 3): SIGIRR (NM_021805)
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                         Customized lentivirus expression plasmids for stable overexpression of SIGIRR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGIRR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIGIRR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TRAF Pathway
    Toll-Like Receptors Pathway0.41

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SIGIRR
        Toll-Like Receptors Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIGIRR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for SIGIRR (Q6IA172, 3 ENSP000003336564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPN1P048432, 3, ENSP000002962554MINT-63381 I2D: score=4 STRING: ENSP00000296255
    ENO2P091042, 3, ENSP000002292774MINT-63437 I2D: score=4 STRING: ENSP00000229277
    IL1R1P147783, ENSP000002339464I2D: score=3 STRING: ENSP00000233946
    IRAK1P516173, ENSP000003589974I2D: score=3 STRING: ENSP00000358997
    MYD88Q998363, ENSP000003796254I2D: score=1 STRING: ENSP00000379625
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001960negative regulation of cytokine-mediated signaling pathway ISS--
    GO:0006953acute-phase response ISS--
    GO:0007165signal transduction IEA--
    GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway TAS15866876
    GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity IMP12925853

    SIGIRR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIGIRR (SIGIR)

    Search CenterWatch for drugs/clinical trials and news about SIGIRR / SIGIR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIGIRR gene (3 alternative transcripts): 
    NM_001135053.1  NM_001135054.1  NM_021805.2  

    Unigene Cluster for SIGIRR:

    Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
    Hs.501624  [show with all ESTs]
    Unigene Representative Sequence: AK093427
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000528845 ENST00000526395 ENST00000431843(uc001lpd.2) ENST00000397632
    ENST00000332725(uc001lpf.2 uc001lpe.1) ENST00000527295 ENST00000527987
    ENST00000531205 ENST00000534145 ENST00000528209 ENST00000525299 ENST00000528698
    ENST00000534217 ENST00000528536 ENST00000526788 ENST00000530494 ENST00000529486
    ENST00000530683
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIGIRR
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGIRR
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGIRR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGIRR

    Additional mRNA sequence: 

    AK025099.1 AK093427.1 AK172830.1 AY358342.1 BC003591.1 BC025953.1 BC106007.1 CR457338.1 

    14 DOTS entries:

    DT.100804117  DT.97804929  DT.442024  DT.92425515  DT.100036286  DT.75102267  DT.92425513  DT.100804122 
    DT.92425514  DT.95300049  DT.120685279  DT.95118220  DT.100804120  DT.97775871 

    24/154 AceView cDNA sequences (see all 154):

    AA582049 AA513675 CB243174 AW272801 CD722327 BI517905 BX400206 BE869865 
    BQ575655 AI741422 BI769076 CF146731 BQ232590 BX382402 CN485211 N36317 
    CB120060 BC025953 AA490620 BI909088 CB137003 AW514150 AI932690 AA679554 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
    SP1:              -     -     -     -     -                       -     -     -     -                                                                           
    SP2:                    -     -     -     -                       -     -     -     -                                                                           
    SP3:                                                              -     -     -     -                                                                           
    SP4:                                                              -     -     -     -                                                                           
    SP5:                    -     -     -     -                       -     -     -     -     -     -                       -                                       

    ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b
    SP1:                    -               
    SP2:                    -               
    SP3:                    -               
    SP4:                                    
    SP5:                    -               


    ECgene alternative splicing isoforms for SIGIRR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIGIRR expression in normal human tissues (normalized intensities)      SIGIRR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATTCTTC
    SIGIRR Expression
    About this image


    SIGIRR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephros
             visceral organ/metanephros/renal medulla   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             cd8+ t cell   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/renal medulla   
     
     Testis (Reproductive System)

    See SIGIRR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIGIRR

    SOURCE GeneReport for Unigene cluster: Hs.501624

    UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17
    Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut

        SABiosciences Expression via Pathway-Focused PCR Arrays including SIGIRR: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGIRR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGIRR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SIGIRR gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sigirr1 , 5 single immunoglobulin and toll-interleukin 1 receptor more1, 5 81.83(n)1
    81.66(a)1
      7 (86.35 cM)5
    240581  NM_023059.31  NP_075546.21 
     1410911755 
    chicken
    (Gallus gallus)
    Aves SIGIRR1 single immunoglobulin and toll-interleukin 1 receptor more 64.82(n)
    59.05(a)
      422995  NM_001199542.1  NP_001186471.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIGIRR6
    Uncharacterized protein
    55(a)
    1 ↔ 1
    1(76496226-76525987)
    zebrafish
    (Danio rerio)
    Actinopterygii sigirr1 single immunoglobulin and toll-interleukin 1 receptor more 53.21(n)
    48.98(a)
      563606  NM_001098250.1  NP_001091720.1 


    ENSEMBL Gene Tree for SIGIRR (if available)
    TreeFam Gene Tree for SIGIRR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/421 SNPs in SIGIRR are shown (see all 421)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459406231,2
    --405411(+) AAGCTC/GAGAAC 3 -- int10--------
    rs1167087851,2
    C,F--405470(+) AAGGGT/CCTAGG 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1394473981,2
    --405595(+) ATTTGG/TCGGGT 3 -- int10--------
    rs1820353811,2
    --405699(+) AGGGAA/GGAGAC 3 -- int10--------
    rs73950121,2
    C,F,H--405705(-) GCCTCA/GGTCTC 3 -- int120Minor allele frequency- G:0.11NS NA WA CSA EA 1842
    rs1493279871,2
    C,F--405890(+) TGGGGT/CGGGAG 3 -- ut311Minor allele frequency- C:0.01EU 1273
    rs1402915061,2
    C,F--405958(+) CGAGCC/GGAGAT 6 R G mis12Minor allele frequency- G:0.00NA EU 5831
    rs1837062131,2
    C--405965(+) AGATCC/TGAGAC 6 S syn10--------
    rs1502345631,2
    C,F--406018(+) GGTGTG/TCGGTG 6 N H mis11Minor allele frequency- T:0.01NA 4264
    rs79471,2
    C,F,H--406043(+) CCAAAA/GACAGG 6 V syn115Minor allele frequency- G:0.18MN NA WA CSA EA 3895

    HapMap Linkage Disequilibrium report for SIGIRR (405716 - 417455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for SIGIRR (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    dgv923n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv930n71CNV Loss21882294
    dgv918n71CNV Loss21882294
    dgv916n71CNV Loss21882294
    dgv926n71CNV Loss21882294
    dgv922n71CNV Loss21882294
    nsv896516CNV Loss21882294
    dgv920n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605478    OMIM disorders: --

    8 diseases for SIGIRR:    About MalaCards
    vaginitis    chronic lymphocytic leukemia    hepatitis c    asthma
    hepatitis    arthritis    tuberculosis    leukemia


    SIGIRR for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SIGIRR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 1.25 2 15866876 (1)
    tumors 0 2 15866876 (1)

    Genetic Association Database (GAD): SIGIRR
    Human Genome Epidemiology (HuGE) Navigator: SIGIRR (4 documents)

    Export disorders for SIGIRR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIGIRR gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SIGIRR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PubMed id 10346978)1, 2, 3, 9 Thomassen E.... Sims J.E. (1999)
    2. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PubMed id 14715412)1, 2, 9 Polentarutti N....Mantovani A. (2003)
    3. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4- mediated signaling through different mechanisms. (PubMed id 15866876)1, 2, 9 Qin J.... Li X. (2005)
    4. A novel binding protein of single immunoglobulin IL-1 receptor- related molecule: Paralemmin-3. (PubMed id 21187075)1, 2 Chen X.... Qian G. (2011)
    5. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. (PubMed id 21077278)1, 2 Kadota C.... Kinoshita Y. (2010)
    6. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    7. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PubMed id 19200604)1, 4 Verstraelen H....Temmerman M. (2009)
    8. An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway. (PubMed id 16432636)1, 4 Nakashima K....Tamari M. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59307 HGNC: 30575 AceView: SIGIRR Ensembl:ENSG00000185187 euGenes: HUgn59307
    ECgene: SIGIRR H-InvDB: SIGIRR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIGIRR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIGIRR gene:
    Search GeneIP for patents involving SIGIRR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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