Aliases for SIGIRR Gene
External Ids for SIGIRR Gene
Previous GeneCards Identifiers for SIGIRR Gene
GeneCards Summary for SIGIRR Gene
SIGIRR (Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and MyD88 cascade initiated on plasma membrane.
UniProtKB/Swiss-Prot for SIGIRR Gene
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.