SIGIRR Gene

Aliases
for SIGIRR gene

Previous GC identifers: GC11U990281 GC11P000782 GC11M000220

Summaries
for SIGIRR gene

Genomic Views
for SIGIRR gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_009237.18  

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIGIRR promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIGIRR

SIGIRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000395:  view genomic region     (about GC identifiers)

Proteins
for SIGIRR gene

Explore the universe of human proteins at neXtProt for SIGIRR: NX_Q6IA17

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SIGIRR
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): SIGIRR OriGene Protein Over-expression Lysate (see all 3): SIGIRR OriGene Custom Protein Services for SIGIRR
	GenScript Custom Purified and Recombinant Proteins Services for SIGIRR
	Novus Biologicals SIGIRR Proteins Novus Biologicals SIGIRR Lysates
	Sino Biological Recombinant Protein for SIGIRR
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SIGIRR

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SIGIRR
	OriGene Antibodies: SIGIRR OriGene Custom Antibody Services for SIGIRR
	GenScript Custom Superior Antibodies Services for SIGIRR
	Novus Biologicals SIGIRR Antibodies
	Search for Antibodies for SIGIRR at Abcam
	Uscn Antibodies for SIGIRR
	ThermoFisher Antibodies for SIGIRR

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SIGIRR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SIGIRR

Protein Domains /
Families
for SIGIRR gene

ProtoNet protein and cluster: Q6IA17

Function
for SIGIRR gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SIGIRR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIGIRR
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SIGIRR
		SwitchGear 3'UTR luciferase reporter plasmid: SIGIRR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIGIRR (see all 7) OriGene shRNA RFP: SIGIRR OriGene siRNA: SIGIRR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIGIRR

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SIGIRR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIGIRR (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIGIRR (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SIGIRR (NM_021805)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIGIRR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIGIRR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SIGIRR
		Search LifeMap BioReagents cell lines for SIGIRR

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGIRR

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Sigirr)

Pathways & Interactions
for SIGIRR gene

	Super-pathway	contained gene-specific pathways
1	TRAF Pathway	Toll-Like Receptors Pathway 0.41

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SIGIRR

Toll-Like Receptors Pathway

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for SIGIRR gene

Transcripts
for SIGIRR gene

Expression
for SIGIRR gene

SIGIRR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATTCTTC

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyEpithelial Tubule			Kidney
	KidneyMetanephros			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	ES04(HES-4) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIGIRR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIGIRR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIGIRR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIGIRR

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIGIRR

Orthologs
for SIGIRR gene

Paralogs
for SIGIRR gene

Paralogs for SIGIRR gene

IL1RAPL2²  IL1RL2²  IL1RAP²  IL1RAPL1²  IL18RAP²  IL18R1²  IL1R2²  IL1RL1²  

IL1R1²  

SIGIRR for paralogs           About GeneDecksing

Genomic Variants
for SIGIRR gene

10/350 NCBI SNPs in SIGIRR are shown (see all 350)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1459406231,2		--	405411(+)	AAGCTC/GAGAAC	3	--	int1		0	--	--	--	--
rs1167087851,2	C,F,	--	405470(+)	AAGGGT/CCTAGG	3	--	int1		1		WA	118
rs1394473981,2		--	405595(+)	ATTTGG/TCGGGT	3	--	int1		0	--	--	--	--
rs1820353811,2		--	405699(+)	AGGGAA/GGAGAC	3	--	int1		0	--	--	--	--
rs73950121,2	C,F,H,	--	405705(-)	GCCTCA/GGTCTC	3	--	int1		20		NS NA WA CSA EA	1842
rs1493279871,2	C,F,	--	405890(+)	TGGGGT/CGGGAG	3	--	ut31		1		EU	1273
rs1402915061,2	C,F,	--	405958(+)	CGAGCC/GGAGAT	6	R G	mis1		2		NA EU	5831
rs1837062131,2	C,	--	405965(+)	AGATCC/TGAGAC	6	S	syn1		0	--	--	--	--
rs1502345631,2	C,F,	--	406018(+)	GGTGTG/TCGGTG	6	N H	mis1		1		NA	4264
rs79471,2	C,F,H,	--	406043(+)	CCAAAA/GACAGG	6	V	syn1		15		MN NA WA CSA EA	3895

HapMap Linkage Disequilibrium report for SIGIRR (405716 - 417455 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SIGIRR
     6 CNVs: 3831 29882 29880 29883 71214 29881

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIGIRR

DNA2.0 Custom Variant and Variant Library Synthesis for SIGIRR

Disorders / Diseases
for SIGIRR gene

8 diseases for SIGIRR

2 Novoseek disease relationships for SIGIRR gene    About this table

Publications
for SIGIRR gene

PubMed articles for SIGIRR gene, integrated from 9 sources (see all 33): (articles sorted by number of sources associating them with SIGIRR)

Utopia: connect your pdf to the dynamic world of online information

1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PubMed id 10346978)^{1, 2, 3, 9} Thomassen E.... Sims J.E. (1999)
2. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PubMed id 14715412)^{1, 2, 9} Polentarutti N....Mantovani A. (2003)
3. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4- mediated signaling through different mechanisms. (PubMed id 15866876)^{1, 2, 9} Qin J.... Li X. (2005)
4. A novel binding protein of single immunoglobulin IL-1 receptor- related molecule: Paralemmin-3. (PubMed id 21187075)^{1, 2} Chen X.... Qian G. (2011)
5. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. (PubMed id 21077278)^{1, 2} Kadota C.... Kinoshita Y. (2010)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. (PubMed id 12925853)^{1, 2} Wald D.... Li X. (2003)
9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
10. The single IgG IL-1-related receptor controls TLR res ponses in differentiated human intestinal epithelial cells. (PubMed id 20130217)^{1, 9} Khan M.A....Vallance B.A. (2010)

External Searches for SIGIRR gene

Genome Databases showing SIGIRR gene

Other Databases showing SIGIRR gene

Specialized Databases showing SIGIRR gene

Products
for SIGIRR gene