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Aliases for SIGIRR Gene

Aliases for SIGIRR Gene

  • Single Ig And TIR Domain Containing 2 3 5
  • Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain 2 3
  • Single Immunoglobulin Domain-Containing IL1R-Related Protein 3 4
  • Single Immunoglobulin Domain IL1R1 Related 2 3
  • Single Ig IL-1R-Related Molecule 3 4
  • Toll/Interleukin-1 Receptor 8 3 4
  • TIR8 3 4
  • Single Ig IL-1-Related Receptor 3
  • IL-1R8 3

External Ids for SIGIRR Gene

Previous GeneCards Identifiers for SIGIRR Gene

  • GC11U990281
  • GC11P000782
  • GC11M000220

Summaries for SIGIRR Gene

GeneCards Summary for SIGIRR Gene

SIGIRR (Single Ig And TIR Domain Containing) is a Protein Coding gene. Diseases associated with SIGIRR include Perinatal Necrotizing Enterocolitis. Among its related pathways are Activated TLR4 signalling and Toll-Like receptor Signaling Pathways.

UniProtKB/Swiss-Prot for SIGIRR Gene

  • Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Gene Wiki entry for SIGIRR Gene

Additional gene information for SIGIRR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGIRR Gene

Genomics for SIGIRR Gene

Regulatory Elements for SIGIRR Gene

Enhancers for SIGIRR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000405 1.2 ENCODE dbSUPER 39.6 +10.5 10450 2.2 HDGF ATF1 SIN3A GLIS2 ELK1 ZNF143 ATF7 RUNX3 SP3 NCOA1 SIGIRR LOC692247 GC11M000414 GC11M000406
GH11H000408 0.8 dbSUPER 36.7 +8.2 8203 1.3 ELF3 TFAP4 SAP130 MAX DMAP1 ZIC2 RAD21 YY1 SCRT2 HNF4G SIGIRR PTDSS2 GC11M000426 GC11M000413
GH11H000391 1.3 ENCODE dbSUPER 22 +22.9 22881 5.2 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF766 GLIS2 ZNF143 SIGIRR PIDD1 DRD4 TMEM80 PKP3 GATD1 ENSG00000255142 ENSG00000255158 PTDSS2 GC11P000395
GH11H000311 1.6 FANTOM5 ENCODE dbSUPER 11.7 +102.6 102587 7 HDGF PKNOX1 ARNT SIN3A ARID4B YY1 ETS1 ZNF766 GLIS2 ZNF207 TMEM80 ENSG00000254910 IFITM3 PGGHG PIDD1 PHRF1 IFITM2 BET1L RIC8A SNORA52
GH11H000403 0.4 dbSUPER 42.3 +13.3 13335 1.3 EZH2 SIGIRR LOC692247 GC11M000414 GC11P000395
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIGIRR on UCSC Golden Path with GeneCards custom track

Promoters for SIGIRR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000262330 455 1201 KLF1 ZNF777 E2F1 POLR2A KLF7 ZBTB20 EZH2 SMARCE1 MAZ RFX1

Genomic Locations for SIGIRR Gene

Genomic Locations for SIGIRR Gene
chr11:405,716-417,455
(GRCh38/hg38)
Size:
11,740 bases
Orientation:
Minus strand
chr11:405,716-417,455
(GRCh37/hg19)

Genomic View for SIGIRR Gene

Genes around SIGIRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGIRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGIRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGIRR Gene

Proteins for SIGIRR Gene

  • Protein details for SIGIRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA17-SIGIR_HUMAN
    Recommended name:
    Single Ig IL-1-related receptor
    Protein Accession:
    Q6IA17
    Secondary Accessions:
    • Q3KQY2
    • Q6UXI3
    • Q9H733

    Protein attributes for SIGIRR Gene

    Size:
    410 amino acids
    Molecular mass:
    45679 Da
    Quaternary structure:
    • Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.

    Alternative splice isoforms for SIGIRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGIRR Gene

Post-translational modifications for SIGIRR Gene

  • Ubiquitination at isoforms=2196
  • Glycosylation at Asn31, isoforms=273, isoforms=286, and isoforms=2102
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SIGIRR

No data available for DME Specific Peptides for SIGIRR Gene

Domains & Families for SIGIRR Gene

Gene Families for SIGIRR Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SIGIRR Gene

Suggested Antigen Peptide Sequences for SIGIRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IA17

UniProtKB/Swiss-Prot:

SIGIR_HUMAN :
  • Belongs to the interleukin-1 receptor family.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with SIGIRR: view

Function for SIGIRR Gene

Molecular function for SIGIRR Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
UniProtKB/Swiss-Prot Induction:
Down-regulated during inflammation by inhibition of an SP1-mediated pathway.

Phenotypes From GWAS Catalog for SIGIRR Gene

Gene Ontology (GO) - Molecular Function for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12925853
genes like me logo Genes that share ontologies with SIGIRR: view
genes like me logo Genes that share phenotypes with SIGIRR: view

Animal Models for SIGIRR Gene

MGI Knock Outs for SIGIRR:

Animal Model Products

miRNA for SIGIRR Gene

miRTarBase miRNAs that target SIGIRR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGIRR Gene

Localization for SIGIRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGIRR Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGIRR gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IMP,IEA 10346978
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGIRR: view

Pathways & Interactions for SIGIRR Gene

genes like me logo Genes that share pathways with SIGIRR: view

Pathways by source for SIGIRR Gene

Gene Ontology (GO) - Biological Process for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0006953 acute-phase response ISS --
GO:0007165 signal transduction IEA --
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway TAS 15866876
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP 12925853
genes like me logo Genes that share ontologies with SIGIRR: view

No data available for SIGNOR curated interactions for SIGIRR Gene

Drugs & Compounds for SIGIRR Gene

No Compound Related Data Available

Transcripts for SIGIRR Gene

Unigene Clusters for SIGIRR Gene

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - -
SP18: -
SP19:
SP20:
SP21:

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:

Relevant External Links for SIGIRR Gene

GeneLoc Exon Structure for
SIGIRR
ECgene alternative splicing isoforms for
SIGIRR

Expression for SIGIRR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGIRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGIRR Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for SIGIRR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIGIRR Gene



Protein tissue co-expression partners for SIGIRR Gene

NURSA nuclear receptor signaling pathways regulating expression of SIGIRR Gene:

SIGIRR

SOURCE GeneReport for Unigene cluster for SIGIRR Gene:

Hs.501624

mRNA Expression by UniProt/SwissProt for SIGIRR Gene:

Q6IA17-SIGIR_HUMAN
Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.

Evidence on tissue expression from TISSUES for SIGIRR Gene

  • Intestine(4.5)
  • Lung(4.5)
  • Liver(4.3)
  • Pancreas(4.2)
  • Spleen(2.4)
  • Kidney(2.3)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with SIGIRR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGIRR Gene

Orthologs for SIGIRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGIRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGIRR 33 34
  • 97.96 (n)
cow
(Bos Taurus)
Mammalia SIGIRR 33 34
  • 85.53 (n)
dog
(Canis familiaris)
Mammalia SIGIRR 33 34
  • 82.44 (n)
mouse
(Mus musculus)
Mammalia Sigirr 33 16 34
  • 81.83 (n)
rat
(Rattus norvegicus)
Mammalia Sigirr 33
  • 80.85 (n)
chicken
(Gallus gallus)
Aves SIGIRR 33 34
  • 64.82 (n)
lizard
(Anolis carolinensis)
Reptilia SIGIRR 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sigirr 33
  • 56.24 (n)
zebrafish
(Danio rerio)
Actinopterygii sigirr 33 34
  • 53.16 (n)
Species where no ortholog for SIGIRR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGIRR Gene

ENSEMBL:
Gene Tree for SIGIRR (if available)
TreeFam:
Gene Tree for SIGIRR (if available)

Paralogs for SIGIRR Gene

No data available for Paralogs for SIGIRR Gene

Variants for SIGIRR Gene

Sequence variations from dbSNP and Humsavar for SIGIRR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193920739 Uncertain significance 418,804(-) AGGGA(C/G)TACCG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1000187452 -- 410,632(+) GGGGG(G/T)GCCCA intron-variant
rs1000326718 -- 414,440(+) CACAG(C/T)CCTCT intron-variant
rs1000378053 -- 406,007(+) GAGAC(C/T)CCACT nc-transcript-variant, reference, synonymous-codon, missense
rs1000410653 -- 406,276(+) GCCCT(A/G)TGCCC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIGIRR Gene

Variant ID Type Subtype PubMed ID
nsv951268 CNV deletion 24416366
nsv552826 CNV gain 21841781
nsv552825 CNV gain+loss 21841781
nsv552824 CNV loss 21841781
nsv552823 CNV loss 21841781
nsv552822 CNV loss 21841781
nsv552776 CNV loss 21841781
nsv552770 CNV gain 21841781
nsv527327 CNV loss 19592680
nsv469923 CNV loss 18288195
nsv467633 CNV loss 19166990
nsv1159790 CNV deletion 26073780
nsv1151392 CNV insertion 26484159
nsv1143665 CNV deletion 24896259
nsv1143663 CNV deletion 24896259
nsv1077764 OTHER inversion 25765185
nsv1070918 CNV deletion 25765185
esv3891907 CNV loss 25118596
esv27645 CNV gain+loss 19812545
esv2759794 CNV loss 17122850
dgv564n106 OTHER inversion 24896259
dgv182e199 CNV deletion 23128226
dgv1505n54 CNV gain 21841781
dgv1012n100 CNV gain 25217958

Variation tolerance for SIGIRR Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGIRR Gene

Human Gene Mutation Database (HGMD)
SIGIRR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGIRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGIRR Gene

Disorders for SIGIRR Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIGIRR Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
perinatal necrotizing enterocolitis
  • enterocolitis necrotizing
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SIGIRR

Genetic Association Database (GAD)
SIGIRR
Human Genome Epidemiology (HuGE) Navigator
SIGIRR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGIRR
genes like me logo Genes that share disorders with SIGIRR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIGIRR Gene

Publications for SIGIRR Gene

  1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PMID: 10346978) Thomassen E … Sims JE (Cytokine 1999) 2 3 4 22 60
  2. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. (PMID: 15866876) Qin J … Li X (The Journal of biological chemistry 2005) 3 4 22 60
  3. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PMID: 14715412) Polentarutti N … Mantovani A (European cytokine network 2003) 3 4 22 60
  4. SIGIRR genetic variants in premature infants with necrotizing enterocolitis. (PMID: 25963006) Sampath V … Dimmock DP (Pediatrics 2015) 3 4 60
  5. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. (PMID: 21187075) Chen X … Qian G (Biochemical and biophysical research communications 2011) 3 4 60

Products for SIGIRR Gene

Sources for SIGIRR Gene

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