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SIGIRR Gene

protein-coding GIFtS: 57

GC11M000395

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC110992 ^²
TIR8 ^¹, ², ³

Descriptions
Single Ig IL-1R-related molecule ^², ³
Single immunoglobulin domain-containing IL1R-related protein ^³
Toll/interleukin-1 receptor 8 ^³
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain ^²
single immunoglobulin and toll-interleukin 1 receptor domain ^¹
single immunoglobulin domain IL1R1 related ^²

External Ids
HGNC: 30575¹
Entrez Gene: 59307²
UniProtKB: Q6IA17³
Ensembl: ENSG00000185187⁷

Search outside databases for aliases for SIGIRR gene

Previous GC identifers: GC11U990281 GC11P000782

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17

Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways.

Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor,

probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain

interferes with the heterodimerization of Il1R1 and IL1RAP

Gene Wiki entry for SIGIRR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SIGIRR gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

SIGIRR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000395: (about GC identifiers)

Start:	395,716 bp from pter
End:	407,397 bp from pter
Size:	11,682 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_035113.6

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17 (See protein sequence)

Recommended Name: Single Ig IL-1-related receptor

Size: 410 amino acids; 45707 Da

Subunit: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a

complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC

found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6

Subcellular location: Membrane; Single-pass type III membrane protein (Potential)

Secondary accessions: Q3KQY2 Q6UXI3 Q9H733

Alternative splicing: 2 isoforms: Q6IA17-1 Q6IA17-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001128525.1 NP_001128526.1 NP_068577.2

ENSEMBL proteins:

ENSP00000371960 ENSP00000380756 ENSP00000333656

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for SIGIRR
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SIGIRR)
	Human Recombinant Proteins from Abnova (SIGIRR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IMP	10346978
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for SIGIRR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SIGIRR
	R&D Systems Antibodies for SIGIRR
	Antibodies from Abcam (SIGIRR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SIGIRR)
	Novus Biologicals Antibodies for SIGIRR

Assays for SIGIRR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q6IA17

ProtoNet protein and cluster: Q6IA17

UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17

Similarity: Belongs to the interleukin-1 receptor family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 TIR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SIGIRR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SIGIRR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021805

Applied Biosystems Silencer® siRNAs for SIGIRR

Sigma-Aldrich siRNA and siRNA Panels for SIGIRR

Sigma-Aldrich shRNA for SIGIRR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SIGIRR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135053
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135053
untagged cDNA clones in CMV expression vector (see all 3): NM_001135053

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021805

UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17

Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways.

Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor,

probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain

interferes with the heterodimerization of Il1R1 and IL1RAP

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sigirr):

digestive/alimentary

immune system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	IEA	--
GO:0005515	protein binding	IPI	12925853

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for SIGIRR

5/12 Interacting proteins for SIGIRR (ENSP00000371960³ Q6IA17²) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENO2	P09104²	MINT-63437
RPN1	P04843²	MINT-63381
IL1B	ENSP00000263341³	STRING (score=.967)
IRAK1	ENSP00000358997³	STRING (score=.914)
TLR9	ENSP00000353874³	STRING (score=.894)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001960	negative regulation of cytokine-mediated signaling pathway	ISS	--
GO:0006953	acute-phase response	ISS	--
GO:0007165	signal transduction	IEA	--
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	TAS	15866876
GO:0043433	negative regulation of transcription factor activity	IMP	12925853

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SIGIRR

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SIGIRR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SIGIRR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021805

Sigma-Aldrich siRNA and siRNA Panels for SIGIRR

Sigma-Aldrich shRNA for SIGIRR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135053 NM_001135054 NM_021805

REFSEQ mRNAs for SIGIRR gene (3 alternative transcripts):

NM_001135053.1 NM_001135054.1 NM_021805.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135053 NM_001135054 NM_021805

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135053
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135053
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001135053

Additional cDNA sequence:

AK025099.1 AK093427.1 AK172830.1 AY358342.1 BC003591.1 BC025953.1 BC106007.1 CR457338.1

14 DOTS entries:

DT.100804117 DT.97804929 DT.442024 DT.92425515 DT.100036286 DT.75102267 DT.92425513 DT.100804122

DT.92425514 DT.95300049 DT.120685279 DT.95118220 DT.100804120 DT.97775871

24/154 AceView cDNA sequences (see all 154 ):

AI741422 AA513675 CB243174 BE869865 CD722327 CN485211 BQ232590 BI769076

N36317 BI517905 AW272801 BX400206 BQ575655 BX382402 CF146731 AA582049

CB243183 AA679554 AK172830 AI052311 BE907720 CB305832 BM924346 BX341382

highest scoring ESTs for SIGIRR:

AA085764 AI961068 AK025099 AK093427 AK172830 BC025953 BM924346 BQ073096 CB137003 CB138796

Unigene Cluster for SIGIRR:

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Hs.501624 [show with all ESTs]

Unigene Representative Sequence: AK093427

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR (see all 21 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	·	4e	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13	^
SP1:					-		-		-		-		-								-		-		-		-
SP2:							-		-		-		-								-		-		-		-
SP3:																					-		-		-		-
SP4:																					-		-		-		-
SP5:							-		-		-		-								-		-		-		-		-		-								-

ExUns:	14a	·	14b	·	14c	·	14d	^	15a	·	15b
SP1:							-
SP2:							-
SP3:							-
SP4:
SP5:							-

About this scheme

ECgene alternative splicing isoforms for SIGIRR

3 Ensembl transcripts including schematic representations:

ENST00000382520 ENST00000397632 ENST00000332725

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SIGIRR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SIGIRR

¹ / ² / ³

7 probe-sets matching SIGIRR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52940_at²^{, 3}	U133-B	1	1.00	1.00	0.95	1.15	AA085764	0.80	1.00	0.91	1
69726_r_at²^{, 3}	U95-E	1	1.00	1.00	0.98	1.04	AI683396	0.60	1.00	0.82	1
79428_s_at²^{, 3}	U95-E	1	0.94	1.00	0.57	0.82	AI961068	0.80	1.00	0.91	1
52940_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA085764	0.80	1.00	0.91	1
218921_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021805	0.60	1.00	0.82	1
52940_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218921_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SIGIRR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGATTCTTC

SOURCE GeneReport for Unigene cluster: Hs.501624
UniProtKB/Swiss-Prot: SIGIR_HUMAN, Q6IA17
Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SIGIRR gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	SIGIRR¹	--	single immunoglobulin and toll-interleukin 1 receptor more	98.92(n) 97.65(a)	743996 XM_001148349.1 XP_001148349.1
cow (Bos taurus)	SIGIRR¹	--	single immunoglobulin and toll-interleukin 1 receptor more	85.45(n) 83.66(a)	531801 XM_610303.3 XP_610303.3
rat (Rattus norvegicus)	Sigirr¹	--	single immunoglobulin and toll-interleukin 1 receptor more	80.68(n) 82.4(a)	309106 NM_001024887.1 NP_001020058.1
mouse (Mus musculus)	Sigirr^{1, 5}	7⁵	single immunoglobulin and toll-interleukin 1 receptor more^{1, 5}	81.74(n)¹ 81.42(a)¹	24058¹ NM_023059.3¹ NP_075546.2¹ AA065595⁵ AF113795⁵ (see all 15)
chicken (Gallus gallus)	SIGIRR¹	--	single immunoglobulin and toll-interleukin 1 receptor more	64.99(n) 59.05(a)	422995 XM_420927.2 XP_420927.1

About this table Species with no ortholog for SIGIRR

ENSEMBL Gene Tree for SIGIRR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SIGIRR gene

IL1RAP² IL1RL1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/159 NCBI SNPs in SIGIRR are shown (see all 159 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3210908^1,2	A,C,F,H	396483(-)	`GGTGCG/AGTACA`	3	R/Q	mis¹		9		MN EU EA WA	1024
--	rs7395012^1,2	C	395705(-)	`GCCTCA/GGTCTC`	1	--	ng5¹		0	--	--	--	--
	rs3087588^1,2	A,C,F	396473(+)	`TCCACC/AGGCCT`	3	P/P	syn¹		1		MN	184
	rs7947^1,2	C,F	396043(+)	`CCAAAA/GACAGG`	3	V/V	syn¹		1		MN	184
--	rs7396562^1,2	A,C,F,H	398352(-)	`TCCAGG/TTTCAG`	1	--	int¹		4		EU EA WA	412
	rs4074794^1,2	A,C,F,H	399815(-)	`CTGCCC/TCTCAG`	1	--	int¹		4		EU EA WA	420
	rs11246149^1,2	F,H	400133(+)	`GCAGCC/TGCATG`	1	--	int¹		4		EU EA WA	418
	rs7951895^1,2	F,H	403012(-)	`CCCTGG/AGGCCC`	1	--	int¹		4		EU EA WA	416
--	rs4076104^1,2	A,C	399592(-)	`GCCCAC/TAGCAG`	1	--	int¹		0	--	--	--	--
--	rs7932576^1,2	A,C	405357(-)	`ACCCCC/TGGAAC`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SIGIRR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605478

2 Novoseek disease relationships for SIGIRR gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	12.68	2	15866876 (1)
tumors	0.00	2	15866876 (1)

About this table

Human Genome Epidemiology Navigator: SIGIRR (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/15 PubMed articles for SIGIRR gene (see all 15 ):

Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PubMed id 10346978)^{1, 2, 3, 4} Thomassen E.... Sims J.E. (1999)
Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PubMed id 14715412)^{1, 3, 4} Polentarutti N....Mantovani A. (2003)
SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4- mediated signaling through different mechanisms. (PubMed id 15866876)^{1, 3, 4} Qin J.... Li X. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. (PubMed id 12925853)^{3, 4} Wald D.... Li X. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PubMed id 19200604)³ Verstraelen H....Temmerman M. (2009)
An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway. (PubMed id 16432636)³ Nakashima K....Tamari M. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 59307	HGNC: 30575	AceView: SIGIRR	Ensembl:ENSG00000185187	euGenes: HUgn59307
ECgene: SIGIRR	H-InvDB: SIGIRR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SIGIRR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SIGIRR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SIGIRR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SIGIRR		Antibodies for SIGIRR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SIGIRR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SIGIRR)
	Antibodies (SIGIRR)
	Chimera RNAi (SIGIRR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (SIGIRR)

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Search Tocris compounds for SIGIRR

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Antibodies for SIGIRR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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SIGIRR Gene at Home site.
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SIGIRR Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for SIGIRR

Summaries
for SIGIRR

Genomic Location
for SIGIRR

Proteins
for SIGIRR

Protein Domains/
Families
for SIGIRR

Gene Function
for SIGIRR

Pathways & Interactions
for SIGIRR

Drugs & Compounds
for SIGIRR

Transcripts
for SIGIRR

Expression
for SIGIRR

Orthologs
for SIGIRR

Paralogs
for SIGIRR

SNPs/Variants
for SIGIRR

Disorders & Mutations
for SIGIRR

Medical News
for SIGIRR

Publications
for SIGIRR

Search for SIGIRR

Genome Databases showing SIGIRR

Other Databases showing SIGIRR

Specialized Databases showing SIGIRR

Licensable Technologies
for SIGIRR

Services
for SIGIRR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SIGIRR Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor SIGIRR

Summariesfor SIGIRR

Genomic Locationfor SIGIRR

Proteinsfor SIGIRR

Protein Domains/Familiesfor SIGIRR

Gene Functionfor SIGIRR

Pathways & Interactionsfor SIGIRR

Drugs & Compoundsfor SIGIRR

Transcriptsfor SIGIRR

Expression for SIGIRR

Orthologsfor SIGIRR

Paralogsfor SIGIRR

SNPs/Variantsfor SIGIRR

Disorders & Mutationsfor SIGIRR

Medical Newsfor SIGIRR

Publicationsfor SIGIRR

Search for SIGIRR

Genome Databases showing SIGIRR

Other Databases showing SIGIRR

Specialized Databases showing SIGIRR

Licensable Technologiesfor SIGIRR

Servicesfor SIGIRR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SIGIRR

Summaries
for SIGIRR

Genomic Location
for SIGIRR

Proteins
for SIGIRR

Protein Domains/
Families
for SIGIRR

Gene Function
for SIGIRR

Pathways & Interactions
for SIGIRR

Drugs & Compounds
for SIGIRR

Transcripts
for SIGIRR

Expression
for SIGIRR

Orthologs
for SIGIRR

Paralogs
for SIGIRR

SNPs/Variants
for SIGIRR

Disorders & Mutations
for SIGIRR

Medical News
for SIGIRR

Publications
for SIGIRR

Licensable Technologies
for SIGIRR

Services
for SIGIRR