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Aliases for SIGIRR Gene

Aliases for SIGIRR Gene

  • Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain 2 3
  • Single Immunoglobulin Domain-Containing IL1R-Related Protein 3 4
  • Single Immunoglobulin Domain IL1R1 Related 2 3
  • Single Ig IL-1R-Related Molecule 3 4
  • Toll/Interleukin-1 Receptor 8 3 4
  • TIR8 3 4
  • Single Ig IL-1-Related Receptor 3

External Ids for SIGIRR Gene

Previous GeneCards Identifiers for SIGIRR Gene

  • GC11U990281
  • GC11P000782
  • GC11M000220

Summaries for SIGIRR Gene

GeneCards Summary for SIGIRR Gene

SIGIRR (Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways and TRAF Pathway.

UniProtKB/Swiss-Prot for SIGIRR Gene

  • Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Gene Wiki entry for SIGIRR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGIRR Gene

Genomics for SIGIRR Gene

Regulatory Elements for SIGIRR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIGIRR Gene

Start:
405,716 bp from pter
End:
417,455 bp from pter
Size:
11,740 bases
Orientation:
Minus strand

Genomic View for SIGIRR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIGIRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGIRR Gene

Proteins for SIGIRR Gene

  • Protein details for SIGIRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA17-SIGIR_HUMAN
    Recommended name:
    Single Ig IL-1-related receptor
    Protein Accession:
    Q6IA17
    Secondary Accessions:
    • Q3KQY2
    • Q6UXI3
    • Q9H733

    Protein attributes for SIGIRR Gene

    Size:
    410 amino acids
    Molecular mass:
    45679 Da
    Quaternary structure:
    • Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.

    Alternative splice isoforms for SIGIRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGIRR Gene

Proteomics data for SIGIRR Gene at MOPED

Post-translational modifications for SIGIRR Gene

  • Ubiquitination at Lys196
  • Glycosylation at Asn31, Asn73, Asn86, and Asn102
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SIGIRR Gene

Domains for SIGIRR Gene

Gene Families for SIGIRR Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for SIGIRR Gene

Suggested Antigen Peptide Sequences for SIGIRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IA17

UniProtKB/Swiss-Prot:

SIGIR_HUMAN :
  • Q6IA17
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with SIGIRR: view

Function for SIGIRR Gene

Molecular function for SIGIRR Gene

UniProtKB/Swiss-Prot Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
UniProtKB/Swiss-Prot Induction: Down-regulated during inflammation by inhibition of an SP1-mediated pathway.

Gene Ontology (GO) - Molecular Function for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12925853
genes like me logo Genes that share ontologies with SIGIRR: view
genes like me logo Genes that share phenotypes with SIGIRR: view

Animal Models for SIGIRR Gene

MGI Knock Outs for SIGIRR:

Animal Model Products

CRISPR Products

miRNA for SIGIRR Gene

miRTarBase miRNAs that target SIGIRR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGIRR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIGIRR Gene

Localization for SIGIRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGIRR Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGIRR Gene COMPARTMENTS Subcellular localization image for SIGIRR gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IMP 10346978
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIGIRR: view

Pathways for SIGIRR Gene

genes like me logo Genes that share pathways with SIGIRR: view

Pathways by source for SIGIRR Gene

1 Qiagen pathway for SIGIRR Gene
1 R&D Systems pathway for SIGIRR Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0006953 acute-phase response ISS --
GO:0007165 signal transduction IEA --
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway TAS 15866876
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP 12925853
genes like me logo Genes that share ontologies with SIGIRR: view

Transcripts for SIGIRR Gene

Unigene Clusters for SIGIRR Gene

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIGIRR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - -
SP18: -
SP19:
SP20:
SP21:

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:

Relevant External Links for SIGIRR Gene

GeneLoc Exon Structure for
SIGIRR
ECgene alternative splicing isoforms for
SIGIRR

Expression for SIGIRR Gene

mRNA expression in normal human tissues for SIGIRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGIRR Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIGIRR Gene

SOURCE GeneReport for Unigene cluster for SIGIRR Gene Hs.501624

mRNA Expression by UniProt/SwissProt for SIGIRR Gene

Q6IA17-SIGIR_HUMAN
Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.
genes like me logo Genes that share expressions with SIGIRR: view

In Situ Assay Products

Orthologs for SIGIRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGIRR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIGIRR 35
  • 97.96 (n)
  • 95.59 (a)
SIGIRR 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIGIRR 35
  • 85.53 (n)
  • 83.9 (a)
SIGIRR 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIGIRR 35
  • 82.44 (n)
  • 79.03 (a)
SIGIRR 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sigirr 35
  • 81.83 (n)
  • 81.66 (a)
Sigirr 16
Sigirr 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sigirr 35
  • 80.85 (n)
  • 82.64 (a)
chicken
(Gallus gallus)
Aves SIGIRR 35
  • 64.82 (n)
  • 59.05 (a)
SIGIRR 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIGIRR 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sigirr 35
  • 56.24 (n)
  • 53.85 (a)
zebrafish
(Danio rerio)
Actinopterygii sigirr 35
  • 53.16 (n)
  • 48.86 (a)
sigirr 36
  • 44 (a)
OneToOne
Species with no ortholog for SIGIRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGIRR Gene

ENSEMBL:
Gene Tree for SIGIRR (if available)
TreeFam:
Gene Tree for SIGIRR (if available)

Paralogs for SIGIRR Gene

No data available for Paralogs for SIGIRR Gene

Variants for SIGIRR Gene

Sequence variations from dbSNP and Humsavar for SIGIRR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7947 -- 406,043(+) CCAAA(A/G)ACAGG reference, synonymous-codon, missense, nc-transcript-variant
rs14702 -- 405,831(+) GTTGA(A/G)CAGAG utr-variant-3-prime, nc-transcript-variant
rs3087588 -- 406,473(+) TCCAC(A/C)GGCCT synonymous-codon, reference, nc-transcript-variant
rs3210908 - 406,483(-) GGTGC(A/G)GTACA reference, missense, nc-transcript-variant
rs3935658 -- 406,755(+) GAGCT(C/G)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIGIRR Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
dgv926n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
nsv896516 CNV Loss 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896530 CNV Gain+Loss 21882294
nsv896532 CNV Gain 21882294
nsv896534 CNV Gain 21882294
essv23843 CNV CNV 17122850
esv27645 CNV Gain+Loss 19812545

Relevant External Links for SIGIRR Gene

HapMap Linkage Disequilibrium report
SIGIRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGIRR Gene

Disorders for SIGIRR Gene

(2) Novoseek inferred disease relationships for SIGIRR Gene

Disease -log(P) Hits PubMed IDs
necrosis 1.25 1
tumors 0 1

Relevant External Links for SIGIRR

Genetic Association Database (GAD)
SIGIRR
Human Genome Epidemiology (HuGE) Navigator
SIGIRR
genes like me logo Genes that share disorders with SIGIRR: view

No data available for UniProtKB/Swiss-Prot for SIGIRR Gene

Publications for SIGIRR Gene

  1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PMID: 10346978) Thomassen E. … Sims J.E. (Cytokine 1999) 2 3 4 23
  2. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PMID: 14715412) Polentarutti N. … Mantovani A. (Eur. Cytokine Netw. 2003) 3 4 23
  3. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4- mediated signaling through different mechanisms. (PMID: 15866876) Qin J. … Li X. (J. Biol. Chem. 2005) 3 4 23
  4. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. (PMID: 19699681) Garlanda C. … Mantovani A. (Trends Immunol. 2009) 3 23
  5. The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. (PMID: 20130217) Khan M.A. … Vallance B.A. (J. Immunol. 2010) 3 23

Products for SIGIRR Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SIGIRR
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SIGIRR
    • Block miRNA regulation of SIGIRR using miScript Target Protectors

    Sources for SIGIRR Gene

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