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Aliases for SIGIRR Gene

Aliases for SIGIRR Gene

  • Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain 2 3 5
  • Single Immunoglobulin Domain-Containing IL1R-Related Protein 3 4
  • Single Immunoglobulin Domain IL1R1 Related 2 3
  • Single Ig IL-1R-Related Molecule 3 4
  • Toll/Interleukin-1 Receptor 8 3 4
  • TIR8 3 4

External Ids for SIGIRR Gene

Previous GeneCards Identifiers for SIGIRR Gene

  • GC11U990281
  • GC11P000782
  • GC11M000220

Summaries for SIGIRR Gene

GeneCards Summary for SIGIRR Gene

SIGIRR (Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain) is a Protein Coding gene. Among its related pathways are Toll-Like receptor Signaling Pathways and MyD88 cascade initiated on plasma membrane.

UniProtKB/Swiss-Prot for SIGIRR Gene

  • Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Gene Wiki entry for SIGIRR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGIRR Gene

Genomics for SIGIRR Gene

Regulatory Elements for SIGIRR Gene

Enhancers for SIGIRR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIGIRR on UCSC Golden Path with GeneCards custom track

Promoters for SIGIRR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIGIRR on UCSC Golden Path with GeneCards custom track

Genomic Location for SIGIRR Gene

Chromosome:
11
Start:
405,716 bp from pter
End:
417,455 bp from pter
Size:
11,740 bases
Orientation:
Minus strand

Genomic View for SIGIRR Gene

Genes around SIGIRR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGIRR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGIRR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGIRR Gene

Proteins for SIGIRR Gene

  • Protein details for SIGIRR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IA17-SIGIR_HUMAN
    Recommended name:
    Single Ig IL-1-related receptor
    Protein Accession:
    Q6IA17
    Secondary Accessions:
    • Q3KQY2
    • Q6UXI3
    • Q9H733

    Protein attributes for SIGIRR Gene

    Size:
    410 amino acids
    Molecular mass:
    45679 Da
    Quaternary structure:
    • Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.

    Alternative splice isoforms for SIGIRR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIGIRR Gene

Proteomics data for SIGIRR Gene at MOPED

Post-translational modifications for SIGIRR Gene

  • Ubiquitination at Lys 196
  • Glycosylation at Asn 31, Asn 73, Asn 86, and Asn 102
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SIGIRR Gene

Domains & Families for SIGIRR Gene

Gene Families for SIGIRR Gene

Protein Domains for SIGIRR Gene

Suggested Antigen Peptide Sequences for SIGIRR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IA17

UniProtKB/Swiss-Prot:

SIGIR_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the interleukin-1 receptor family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with SIGIRR: view

Function for SIGIRR Gene

Molecular function for SIGIRR Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
UniProtKB/Swiss-Prot Induction:
Down-regulated during inflammation by inhibition of an SP1-mediated pathway.
genes like me logo Genes that share phenotypes with SIGIRR: view

Animal Models for SIGIRR Gene

MGI Knock Outs for SIGIRR:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIGIRR

miRNA for SIGIRR Gene

miRTarBase miRNAs that target SIGIRR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIGIRR Gene

Localization for SIGIRR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGIRR Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIGIRR Gene COMPARTMENTS Subcellular localization image for SIGIRR gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SIGIRR Gene

Pathways & Interactions for SIGIRR Gene

genes like me logo Genes that share pathways with SIGIRR: view

Pathways by source for SIGIRR Gene

Gene Ontology (GO) - Biological Process for SIGIRR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS --
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP 12925853
genes like me logo Genes that share ontologies with SIGIRR: view

No data available for SIGNOR curated interactions for SIGIRR Gene

Drugs & Compounds for SIGIRR Gene

No Compound Related Data Available

Transcripts for SIGIRR Gene

Unigene Clusters for SIGIRR Gene

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIGIRR Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - -
SP12: - - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - -
SP18: -
SP19:
SP20:
SP21:

ExUns: 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:

Relevant External Links for SIGIRR Gene

GeneLoc Exon Structure for
SIGIRR
ECgene alternative splicing isoforms for
SIGIRR

Expression for SIGIRR Gene

mRNA expression in normal human tissues for SIGIRR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGIRR Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for SIGIRR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.3) and NK cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIGIRR Gene



SOURCE GeneReport for Unigene cluster for SIGIRR Gene Hs.501624

mRNA Expression by UniProt/SwissProt for SIGIRR Gene

Q6IA17-SIGIR_HUMAN
Tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.
genes like me logo Genes that share expression patterns with SIGIRR: view

Protein tissue co-expression partners for SIGIRR Gene

Primer Products

Orthologs for SIGIRR Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIGIRR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIGIRR 35
  • 85.53 (n)
  • 83.9 (a)
SIGIRR 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIGIRR 35
  • 82.44 (n)
  • 79.03 (a)
SIGIRR 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sigirr 35
  • 81.83 (n)
  • 81.66 (a)
Sigirr 16
Sigirr 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIGIRR 35
  • 97.96 (n)
  • 95.59 (a)
SIGIRR 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sigirr 35
  • 80.85 (n)
  • 82.64 (a)
chicken
(Gallus gallus)
Aves SIGIRR 35
  • 64.82 (n)
  • 59.05 (a)
SIGIRR 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIGIRR 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sigirr 35
  • 56.24 (n)
  • 53.85 (a)
zebrafish
(Danio rerio)
Actinopterygii sigirr 35
  • 53.16 (n)
  • 48.86 (a)
sigirr 36
  • 44 (a)
OneToOne
Species with no ortholog for SIGIRR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIGIRR Gene

ENSEMBL:
Gene Tree for SIGIRR (if available)
TreeFam:
Gene Tree for SIGIRR (if available)

Paralogs for SIGIRR Gene

No data available for Paralogs for SIGIRR Gene

Variants for SIGIRR Gene

Sequence variations from dbSNP and Humsavar for SIGIRR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3210908 - 406,483(-) GGTGC(A/G)GTACA nc-transcript-variant, reference, missense
VAR_074164 -
VAR_074165 -
rs7131456 -- 410,462(-) GCATC(C/T)CCCAT intron-variant
rs7395012 -- 405,705(-) GCCTC(A/G)GTCTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SIGIRR Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
dgv926n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
nsv896516 CNV Loss 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896530 CNV Gain+Loss 21882294
nsv896532 CNV Gain 21882294
nsv896534 CNV Gain 21882294
essv23843 CNV CNV 17122850
esv27645 CNV Gain+Loss 19812545

Variation tolerance for SIGIRR Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIGIRR Gene

Human Gene Mutation Database (HGMD)
SIGIRR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGIRR Gene

Disorders for SIGIRR Gene

Relevant External Links for SIGIRR

Genetic Association Database (GAD)
SIGIRR
Human Genome Epidemiology (HuGE) Navigator
SIGIRR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIGIRR

No disorders were found for SIGIRR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGIRR Gene

Publications for SIGIRR Gene

  1. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. (PMID: 10346978) Thomassen E. … Sims J.E. (Cytokine 1999) 2 3 4 23 67
  2. The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. (PMID: 20130217) Khan M.A. … Vallance B.A. (J. Immunol. 2010) 3 23
  3. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. (PMID: 19699681) Garlanda C. … Mantovani A. (Trends Immunol. 2009) 3 23
  4. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4- mediated signaling through different mechanisms. (PMID: 15866876) Qin J. … Li X. (J. Biol. Chem. 2005) 3 23
  5. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. (PMID: 14715412) Polentarutti N. … Mantovani A. (Eur. Cytokine Netw. 2003) 3 23

Products for SIGIRR Gene

Sources for SIGIRR Gene

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