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Aliases for SIDT2 Gene

Aliases for SIDT2 Gene

  • SID1 Transmembrane Family Member 2 2 3 5
  • SID1 Transmembrane Family, Member 2 2
  • CGI-40 3

External Ids for SIDT2 Gene

Previous GeneCards Identifiers for SIDT2 Gene

  • GC11P116554
  • GC11P117049
  • GC11P112982

Summaries for SIDT2 Gene

GeneCards Summary for SIDT2 Gene

SIDT2 (SID1 Transmembrane Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT2 Gene

Genomics for SIDT2 Gene

Regulatory Elements for SIDT2 Gene

Enhancers for SIDT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G117177 1.6 FANTOM5 ENCODE dbSUPER 7.7 +2.6 2627 7.4 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 YY1 LOC653303 PAFAH1B2 APOA1 ENSG00000254678 APOA5 ZPR1 SIDT2 PIR62498
GH11G117197 1.3 ENCODE dbSUPER 6.9 +23.1 23083 9.3 FOXA2 PKNOX1 ARNT MLX AGO1 ARID4B DMAP1 FEZF1 YY1 SLC30A9 LOC653303 PCSK7 APOA1 RNF214 SIDT2 TAGLN LOC100652768
GH11G117185 1.3 Ensembl ENCODE dbSUPER 6.4 +9.2 9208 5.6 ZNF121 ZNF143 FOS RELB IKZF2 YY2 USF2 CEBPB GATAD2B TBX21 LOC653303 APOA1 RNF214 PCSK7 ENSG00000254678 PAFAH1B2 BUD13 ENSG00000226645 SIDT2 PIR62498
GH11G117216 1.5 Ensembl ENCODE dbSUPER 4.8 +41.1 41097 7.5 FOXA2 YY1 TCF12 ZNF121 ZNF766 GATA2 JUNB MXD4 REST ZNF623 LOC653303 APOA1 PCSK7 SIDT2 ENSG00000280143
GH11G117050 0.6 dbSUPER 6 -125.2 -125224 5.8 ZNF121 SCRT1 ZNF146 PRDM6 EED ZNF580 APOA1 LOC653303 SIK3 ENSG00000224077 ENSG00000226645 BUD13 SIDT2 RPS27P19 GC11M117070
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIDT2 on UCSC Golden Path with GeneCards custom track

Promoters for SIDT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SIDT2 Gene

117,178,733 bp from pter
117,197,445 bp from pter
18,713 bases
Plus strand

Genomic View for SIDT2 Gene

Genes around SIDT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIDT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIDT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT2 Gene

Proteins for SIDT2 Gene

  • Protein details for SIDT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SID1 transmembrane family member 2
    Protein Accession:
    Secondary Accessions:
    • Q8NBY7
    • Q9Y357

    Protein attributes for SIDT2 Gene

    832 amino acids
    Molecular mass:
    94454 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11427.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIDT2 Gene


neXtProt entry for SIDT2 Gene

Post-translational modifications for SIDT2 Gene

  • Glycosylated.
  • Glycosylation at isoforms=227, Asn54, Asn60, isoforms=2123, isoforms=2141, Asn165, isoforms=2476, Asn496, Asn572, and isoforms=2603
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIDT2 Gene

Domains & Families for SIDT2 Gene

Protein Domains for SIDT2 Gene


Suggested Antigen Peptide Sequences for SIDT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SID1 family.
  • Belongs to the SID1 family.
genes like me logo Genes that share domains with SIDT2: view

No data available for Gene Families for SIDT2 Gene

Function for SIDT2 Gene

Gene Ontology (GO) - Molecular Function for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IEA --
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SIDT2: view
genes like me logo Genes that share phenotypes with SIDT2: view

Animal Models for SIDT2 Gene

MGI Knock Outs for SIDT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIDT2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIDT2 Gene

Localization for SIDT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT2 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIDT2 gene
Compartment Confidence
lysosome 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 17897319
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIDT2: view

Pathways & Interactions for SIDT2 Gene

SuperPathways for SIDT2 Gene

No Data Available

Interacting Proteins for SIDT2 Gene

Gene Ontology (GO) - Biological Process for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0003323 type B pancreatic cell development IEA --
GO:0009749 response to glucose IEA --
GO:0033227 dsRNA transport IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with SIDT2: view

No data available for Pathways by source and SIGNOR curated interactions for SIDT2 Gene

Drugs & Compounds for SIDT2 Gene

No Compound Related Data Available

Transcripts for SIDT2 Gene

Unigene Clusters for SIDT2 Gene

SID1 transmembrane family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP6: - -
SP12: - -

ExUns: 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c
SP1: - - - -
SP2: - - - -
SP5: -
SP7: - - -
SP9: - -

Relevant External Links for SIDT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIDT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIDT2 Gene

Protein differential expression in normal tissues from HIPED for SIDT2 Gene

This gene is overexpressed in Pancreas (24.7), Placenta (15.2), Testis (15.0), and Ovary (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIDT2 Gene

Protein tissue co-expression partners for SIDT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIDT2 Gene:


SOURCE GeneReport for Unigene cluster for SIDT2 Gene:


Evidence on tissue expression from TISSUES for SIDT2 Gene

  • Nervous system(3.8)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SIDT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIDT2 Gene

Orthologs for SIDT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIDT2 34 35
  • 99.44 (n)
(Bos Taurus)
Mammalia SIDT2 34 35
  • 91.34 (n)
(Canis familiaris)
Mammalia SIDT2 34 35
  • 91.12 (n)
(Mus musculus)
Mammalia Sidt2 34 16 35
  • 89.82 (n)
(Rattus norvegicus)
Mammalia Sidt2 34
  • 89.22 (n)
(Monodelphis domestica)
Mammalia SIDT2 35
  • 89 (a)
(Gallus gallus)
Aves SIDT2 34 35
  • 80.02 (n)
(Anolis carolinensis)
Reptilia SIDT2 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt2 34
  • 67.96 (n)
Str.18477 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14690 34
(Danio rerio)
Actinopterygii sidt2 35
  • 69 (a)
wufc73a07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6494 34
(Caenorhabditis elegans)
Secernentea tag-130 34
  • 46.57 (n)
chup-1 35
  • 35 (a)
sid-1 35
  • 21 (a)
Species where no ortholog for SIDT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIDT2 Gene

Gene Tree for SIDT2 (if available)
Gene Tree for SIDT2 (if available)

Paralogs for SIDT2 Gene

Paralogs for SIDT2 Gene

genes like me logo Genes that share paralogs with SIDT2: view

Variants for SIDT2 Gene

Sequence variations from dbSNP and Humsavar for SIDT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000113010 -- 117,183,280(+) ACAGA(A/G)GTTGC intron-variant
rs1000166602 -- 117,186,438(+) CTCCC(C/T)AGCCT intron-variant
rs1000281405 -- 117,184,672(+) ATATT(G/T)ACTGA intron-variant
rs1000308337 -- 117,178,112(+) GAAAC(A/G)GTGCC nc-transcript-variant, upstream-variant-2KB
rs1000333880 -- 117,196,447(+) CACAA(G/T)GCCCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIDT2 Gene

Variant ID Type Subtype PubMed ID
dgv2186n54 CNV loss 21841781
dgv730n106 OTHER inversion 24896259
nsv1078301 OTHER inversion 25765185
nsv518908 CNV loss 19592680
nsv524270 CNV loss 19592680
nsv7223 OTHER inversion 18451855

Variation tolerance for SIDT2 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIDT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT2 Gene

Disorders for SIDT2 Gene

Relevant External Links for SIDT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIDT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIDT2 Gene

Publications for SIDT2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4 64

Products for SIDT2 Gene

Sources for SIDT2 Gene

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