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Aliases for SIDT2 Gene

Aliases for SIDT2 Gene

  • SID1 Transmembrane Family, Member 2 2 3
  • SID1 Transmembrane Family Member 2 3
  • CGI-40 3

External Ids for SIDT2 Gene

Summaries for SIDT2 Gene

GeneCards Summary for SIDT2 Gene

SIDT2 (SID1 Transmembrane Family, Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT2 Gene

Genomics for SIDT2 Gene

Genomic Location for SIDT2 Gene

Start:
117,178,733 bp from pter
End:
117,197,445 bp from pter
Size:
18,713 bases
Orientation:
Plus strand

Genomic View for SIDT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIDT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT2 Gene

Regulatory Elements for SIDT2 Gene

Proteins for SIDT2 Gene

  • Protein details for SIDT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ9-SIDT2_HUMAN
    Recommended name:
    SID1 transmembrane family member 2
    Protein Accession:
    Q8NBJ9
    Secondary Accessions:
    • Q8NBY7
    • Q9Y357

    Protein attributes for SIDT2 Gene

    Size:
    832 amino acids
    Molecular mass:
    94454 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11427.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIDT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIDT2 Gene

Proteomics data for SIDT2 Gene at MOPED

Post-translational modifications for SIDT2 Gene

  • Glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn27, Asn54, Asn60, Asn123, Asn141, Asn165, Asn476, Asn496, Asn572, and Asn603

No data available for DME Specific Peptides for SIDT2 Gene

Domains for SIDT2 Gene

Protein Domains for SIDT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SIDT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBJ9

UniProtKB/Swiss-Prot:

SIDT2_HUMAN
Family:
  • Belongs to the SID1 family.:
    • Q8NBJ9
genes like me logo Genes that share domains with SIDT2: view

No data available for Gene Families for SIDT2 Gene

Function for SIDT2 Gene

Gene Ontology (GO) - Molecular Function for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SIDT2: view
genes like me logo Genes that share phenotypes with SIDT2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIDT2 Gene

Localization for SIDT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT2 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIDT2 Gene COMPARTMENTS Subcellular localization image for SIDT2 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIDT2: view

Pathways for SIDT2 Gene

SuperPathways for SIDT2 Gene

No Data Available

Interacting Proteins for SIDT2 Gene

Gene Ontology (GO) - Biological Process for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0003323 type B pancreatic cell development IEA --
GO:0009749 response to glucose IEA --
GO:0033227 dsRNA transport IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with SIDT2: view

No data available for Pathways by source for SIDT2 Gene

Transcripts for SIDT2 Gene

Unigene Clusters for SIDT2 Gene

SID1 transmembrane family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7: - - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SIDT2 Gene

GeneLoc Exon Structure for
SIDT2
ECgene alternative splicing isoforms for
SIDT2

Expression for SIDT2 Gene

mRNA expression in normal human tissues for SIDT2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SIDT2 Gene

SOURCE GeneReport for Unigene cluster for SIDT2 Gene Hs.712144

genes like me logo Genes that share expressions with SIDT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIDT2 Gene

Orthologs for SIDT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIDT2 35
  • 99.44 (n)
  • 99.76 (a)
SIDT2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIDT2 35
  • 91.34 (n)
  • 96.49 (a)
SIDT2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIDT2 35
  • 91.12 (n)
  • 97.28 (a)
SIDT2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sidt2 35
  • 89.82 (n)
  • 95.43 (a)
Sidt2 16
Sidt2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIDT2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sidt2 35
  • 89.22 (n)
  • 95.67 (a)
chicken
(Gallus gallus)
Aves SIDT2 35
  • 80.02 (n)
  • 84.24 (a)
SIDT2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIDT2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt2 35
  • 67.96 (n)
  • 76.56 (a)
Str.18477 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6494 35
zebrafish
(Danio rerio)
Actinopterygii sidt2 36
  • 69 (a)
OneToOne
wufc73a07 35
worm
(Caenorhabditis elegans)
Secernentea chup-1 36
  • 35 (a)
ManyToMany
sid-1 36
  • 21 (a)
ManyToMany
tag-130 35
  • 46.57 (n)
  • 38.84 (a)
Species with no ortholog for SIDT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIDT2 Gene

ENSEMBL:
Gene Tree for SIDT2 (if available)
TreeFam:
Gene Tree for SIDT2 (if available)

Paralogs for SIDT2 Gene

Paralogs for SIDT2 Gene

genes like me logo Genes that share paralogs with SIDT2: view

Variants for SIDT2 Gene

Sequence variations from dbSNP and Humsavar for SIDT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs90192 -- 117,188,631(-) CAATT(A/G)TAACA intron-variant
rs474339 -- 117,188,836(-) GCCCA(C/T)GGGTC intron-variant
rs499713 -- 117,191,245(-) AGGCT(A/G)GAGCG intron-variant
rs521171 -- 117,193,977(-) CCTGA(C/G)GGTGA intron-variant
rs729621 -- 117,178,884(+) AGCCC(C/T)CGCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIDT2 Gene

Variant ID Type Subtype PubMed ID
nsv7223 OTHER Inversion 18451855
nsv518908 CNV Loss 19592680
nsv524270 CNV Loss 19592680

Relevant External Links for SIDT2 Gene

HapMap Linkage Disequilibrium report
SIDT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT2 Gene

Disorders for SIDT2 Gene

Relevant External Links for SIDT2

Genetic Association Database (GAD)
SIDT2
Human Genome Epidemiology (HuGE) Navigator
SIDT2
genes like me logo Genes that share disorders with SIDT2: view

No data available for UniProtKB/Swiss-Prot for SIDT2 Gene

Publications for SIDT2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SIDT2 Gene

Sources for SIDT2 Gene

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