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Aliases for SIDT2 Gene

Aliases for SIDT2 Gene

  • SID1 Transmembrane Family Member 2 2 3 5
  • SID1 Transmembrane Family, Member 2 2 3
  • CGI-40 3

External Ids for SIDT2 Gene

Previous GeneCards Identifiers for SIDT2 Gene

  • GC11P116554
  • GC11P117049
  • GC11P112982

Summaries for SIDT2 Gene

GeneCards Summary for SIDT2 Gene

SIDT2 (SID1 Transmembrane Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT2 Gene

Genomics for SIDT2 Gene

Regulatory Elements for SIDT2 Gene

Promoters for SIDT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIDT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIDT2 Gene

Chromosome:
11
Start:
117,178,733 bp from pter
End:
117,197,445 bp from pter
Size:
18,713 bases
Orientation:
Plus strand

Genomic View for SIDT2 Gene

Genes around SIDT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIDT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIDT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT2 Gene

Proteins for SIDT2 Gene

  • Protein details for SIDT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ9-SIDT2_HUMAN
    Recommended name:
    SID1 transmembrane family member 2
    Protein Accession:
    Q8NBJ9
    Secondary Accessions:
    • Q8NBY7
    • Q9Y357

    Protein attributes for SIDT2 Gene

    Size:
    832 amino acids
    Molecular mass:
    94454 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11427.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIDT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIDT2 Gene

Proteomics data for SIDT2 Gene at MOPED

Post-translational modifications for SIDT2 Gene

  • Glycosylated.
  • Glycosylation at Asn 27, Asn 54, Asn 60, Asn 123, Asn 141, Asn 165, Asn 476, Asn 496, Asn 572, and Asn 603
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIDT2 Gene

Domains & Families for SIDT2 Gene

Protein Domains for SIDT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SIDT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBJ9

UniProtKB/Swiss-Prot:

SIDT2_HUMAN :
  • Belongs to the SID1 family.
Family:
  • Belongs to the SID1 family.
genes like me logo Genes that share domains with SIDT2: view

No data available for Gene Families for SIDT2 Gene

Function for SIDT2 Gene

genes like me logo Genes that share phenotypes with SIDT2: view

Animal Models for SIDT2 Gene

MGI Knock Outs for SIDT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIDT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIDT2 Gene

Localization for SIDT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT2 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIDT2 Gene COMPARTMENTS Subcellular localization image for SIDT2 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for SIDT2 Gene

Pathways & Interactions for SIDT2 Gene

SuperPathways for SIDT2 Gene

No Data Available

Interacting Proteins for SIDT2 Gene

Gene Ontology (GO) - Biological Process for SIDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0033227 dsRNA transport IEA --
GO:0042593 glucose homeostasis IEA --
genes like me logo Genes that share ontologies with SIDT2: view

No data available for Pathways by source and SIGNOR curated interactions for SIDT2 Gene

Drugs & Compounds for SIDT2 Gene

No Compound Related Data Available

Transcripts for SIDT2 Gene

Unigene Clusters for SIDT2 Gene

SID1 transmembrane family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7: - - -
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SIDT2 Gene

GeneLoc Exon Structure for
SIDT2
ECgene alternative splicing isoforms for
SIDT2

Expression for SIDT2 Gene

mRNA expression in normal human tissues for SIDT2 Gene

Protein differential expression in normal tissues from HIPED for SIDT2 Gene

This gene is overexpressed in Pancreas (24.7), Placenta (15.2), Testis (15.0), and Ovary (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SIDT2 Gene



SOURCE GeneReport for Unigene cluster for SIDT2 Gene Hs.712144

genes like me logo Genes that share expression patterns with SIDT2: view

Protein tissue co-expression partners for SIDT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIDT2 Gene

Orthologs for SIDT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIDT2 36
  • 100 (a)
OneToOne
SIDT2 35
  • 99.44 (n)
  • 99.76 (a)
cow
(Bos Taurus)
Mammalia SIDT2 36
  • 96 (a)
OneToOne
SIDT2 35
  • 91.34 (n)
  • 96.49 (a)
dog
(Canis familiaris)
Mammalia SIDT2 35
  • 91.12 (n)
  • 97.28 (a)
SIDT2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sidt2 36
  • 95 (a)
OneToOne
Sidt2 16
Sidt2 35
  • 89.82 (n)
  • 95.43 (a)
oppossum
(Monodelphis domestica)
Mammalia SIDT2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sidt2 35
  • 89.22 (n)
  • 95.67 (a)
chicken
(Gallus gallus)
Aves SIDT2 35
  • 80.02 (n)
  • 84.24 (a)
SIDT2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIDT2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt2 35
  • 67.96 (n)
  • 76.56 (a)
Str.18477 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6494 35
zebrafish
(Danio rerio)
Actinopterygii wufc73a07 35
sidt2 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea chup-1 36
  • 35 (a)
ManyToMany
sid-1 36
  • 21 (a)
ManyToMany
tag-130 35
  • 46.57 (n)
  • 38.84 (a)
Species with no ortholog for SIDT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIDT2 Gene

ENSEMBL:
Gene Tree for SIDT2 (if available)
TreeFam:
Gene Tree for SIDT2 (if available)

Paralogs for SIDT2 Gene

Paralogs for SIDT2 Gene

genes like me logo Genes that share paralogs with SIDT2: view

Variants for SIDT2 Gene

Sequence variations from dbSNP and Humsavar for SIDT2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs521171 -- 117,193,977(-) CCTGA(C/G/T)GGTGA intron-variant
rs729621 -- 117,178,884(+) AGCCC(C/T)CGCCG upstream-variant-2KB
rs1242229 -- 117,191,654(-) CTGAA(A/G)ACAGG intron-variant
rs1242230 -- 117,191,467(-) AGCTG(A/G)GATTA intron-variant
rs1784042 -- 117,194,760(+) TTCCT(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIDT2 Gene

Variant ID Type Subtype PubMed ID
nsv7223 OTHER Inversion 18451855
nsv518908 CNV Loss 19592680
nsv524270 CNV Loss 19592680

Variation tolerance for SIDT2 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 60.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIDT2 Gene

HapMap Linkage Disequilibrium report
SIDT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT2 Gene

Disorders for SIDT2 Gene

Relevant External Links for SIDT2

Genetic Association Database (GAD)
SIDT2
Human Genome Epidemiology (HuGE) Navigator
SIDT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIDT2

No disorders were found for SIDT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIDT2 Gene

Publications for SIDT2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3

Products for SIDT2 Gene

Sources for SIDT2 Gene

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