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Aliases for SIDT1 Gene

Aliases for SIDT1 Gene

  • SID1 Transmembrane Family Member 1 2 3 5
  • SID1 Transmembrane Family, Member 1 2 3
  • SID-1 3
  • SID1 3

External Ids for SIDT1 Gene

Previous GeneCards Identifiers for SIDT1 Gene

  • GC03P114734
  • GC03P113251
  • GC03P110626

Summaries for SIDT1 Gene

GeneCards Summary for SIDT1 Gene

SIDT1 (SID1 Transmembrane Family Member 1) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT1 Gene

Genomics for SIDT1 Gene

Regulatory Elements for SIDT1 Gene

Enhancers for SIDT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIDT1 on UCSC Golden Path with GeneCards custom track

Promoters for SIDT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIDT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIDT1 Gene

Chromosome:
3
Start:
113,532,296 bp from pter
End:
113,632,097 bp from pter
Size:
99,802 bases
Orientation:
Plus strand

Genomic View for SIDT1 Gene

Genes around SIDT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT1 Gene

Proteins for SIDT1 Gene

  • Protein details for SIDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXL6-SIDT1_HUMAN
    Recommended name:
    SID1 transmembrane family member 1
    Protein Accession:
    Q9NXL6
    Secondary Accessions:
    • Q17RR4

    Protein attributes for SIDT1 Gene

    Size:
    827 amino acids
    Molecular mass:
    93839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIDT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIDT1 Gene

Proteomics data for SIDT1 Gene at MOPED

Post-translational modifications for SIDT1 Gene

  • Glycosylation at Asn 57, Asn 67, Asn 83, Asn 136, Asn 282, Asn 471, Asn 567, and Asn 764
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIDT1 Gene

Domains & Families for SIDT1 Gene

Protein Domains for SIDT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SIDT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXL6

UniProtKB/Swiss-Prot:

SIDT1_HUMAN :
  • Belongs to the SID1 family.
Family:
  • Belongs to the SID1 family.
genes like me logo Genes that share domains with SIDT1: view

No data available for Gene Families for SIDT1 Gene

Function for SIDT1 Gene

genes like me logo Genes that share phenotypes with SIDT1: view

Animal Model Products

miRNA for SIDT1 Gene

miRTarBase miRNAs that target SIDT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIDT1 Gene

Localization for SIDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIDT1 Gene COMPARTMENTS Subcellular localization image for SIDT1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for SIDT1 Gene

Pathways & Interactions for SIDT1 Gene

SuperPathways for SIDT1 Gene

No Data Available

Interacting Proteins for SIDT1 Gene

Gene Ontology (GO) - Biological Process for SIDT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SIDT1 Gene

Drugs & Compounds for SIDT1 Gene

No Compound Related Data Available

Transcripts for SIDT1 Gene

Unigene Clusters for SIDT1 Gene

SID1 transmembrane family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SIDT1 Gene

GeneLoc Exon Structure for
SIDT1
ECgene alternative splicing isoforms for
SIDT1

Expression for SIDT1 Gene

mRNA expression in normal human tissues for SIDT1 Gene

Protein differential expression in normal tissues from HIPED for SIDT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.1) and Breast (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIDT1 Gene



SOURCE GeneReport for Unigene cluster for SIDT1 Gene Hs.591291

genes like me logo Genes that share expression patterns with SIDT1: view

Protein tissue co-expression partners for SIDT1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIDT1 Gene

Orthologs for SIDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIDT1 35
  • 89.02 (n)
  • 91.62 (a)
SIDT1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIDT1 35
  • 89.74 (n)
  • 92.84 (a)
SIDT1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sidt1 35
  • 87.39 (n)
  • 91.94 (a)
Sidt1 16
Sidt1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIDT1 35
  • 99.31 (n)
  • 99.64 (a)
SIDT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sidt1 35
  • 87.16 (n)
  • 91.55 (a)
oppossum
(Monodelphis domestica)
Mammalia SIDT1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves SIDT1 35
  • 77.74 (n)
  • 82.83 (a)
SIDT1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIDT1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt1 35
  • 70.24 (n)
  • 70.92 (a)
worm
(Caenorhabditis elegans)
Secernentea chup-1 36
  • 34 (a)
ManyToMany
sid-1 36
  • 22 (a)
ManyToMany
Species with no ortholog for SIDT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SIDT1 Gene

ENSEMBL:
Gene Tree for SIDT1 (if available)
TreeFam:
Gene Tree for SIDT1 (if available)

Paralogs for SIDT1 Gene

Paralogs for SIDT1 Gene

(1) SIMAP similar genes for SIDT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIDT1: view

Variants for SIDT1 Gene

Sequence variations from dbSNP and Humsavar for SIDT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2271496 - 113,566,429(-) CCTCA(C/G/T)GGCTG nc-transcript-variant, reference, missense
rs33990195 - 113,601,630(+) CAGCA(C/T)ACCCG nc-transcript-variant, reference, missense
rs9879313 - 113,533,028(+) TGCGC(A/G)GCTGC nc-transcript-variant, reference, missense
rs1869631 -- 113,623,338(-) GGGAA(A/G)GGGCA intron-variant
rs2278941 -- 113,631,661(-) TGTGA(C/T)TCTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIDT1 Gene

Variant ID Type Subtype PubMed ID
dgv5232n71 CNV Loss 21882294
nsv524086 CNV Loss 19592680
esv2265706 CNV Deletion 18987734

Variation tolerance for SIDT1 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIDT1 Gene

Disorders for SIDT1 Gene

Relevant External Links for SIDT1

Genetic Association Database (GAD)
SIDT1
Human Genome Epidemiology (HuGE) Navigator
SIDT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIDT1

No disorders were found for SIDT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIDT1 Gene

Publications for SIDT1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. (PMID: 15850781) Duxbury M.S. … Whang E.E. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. (PMID: 22174421) Elhassan M.O. … Duxbury M.S. (J. Biol. Chem. 2012) 3
  5. Preparation and characterization of the extracellular domain of human Sid-1. (PMID: 22509261) Pratt A.J. … MacRae I.J. (PLoS ONE 2012) 3

Products for SIDT1 Gene

Sources for SIDT1 Gene

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