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Aliases for SIDT1 Gene

Aliases for SIDT1 Gene

  • SID1 Transmembrane Family, Member 1 2 3
  • SID1 Transmembrane Family Member 1 3
  • B830021E24Rik 3
  • SID-1 3
  • SID1 3

External Ids for SIDT1 Gene

Summaries for SIDT1 Gene

GeneCards Summary for SIDT1 Gene

SIDT1 (SID1 Transmembrane Family, Member 1) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT1 Gene

Genomics for SIDT1 Gene

Genomic Location for SIDT1 Gene

Start:
113,532,296 bp from pter
End:
113,629,578 bp from pter
Size:
97,283 bases
Orientation:
Plus strand

Genomic View for SIDT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT1 Gene

Regulatory Elements for SIDT1 Gene

Proteins for SIDT1 Gene

  • Protein details for SIDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXL6-SIDT1_HUMAN
    Recommended name:
    SID1 transmembrane family member 1
    Protein Accession:
    Q9NXL6
    Secondary Accessions:
    • Q17RR4

    Protein attributes for SIDT1 Gene

    Size:
    827 amino acids
    Molecular mass:
    93839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIDT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIDT1 Gene

Proteomics data for SIDT1 Gene at MOPED

Post-translational modifications for SIDT1 Gene

  • Glycosylation at Asn57, Asn67, Asn83, Asn136, Asn282, Asn471, Asn567, and Asn764

Other Protein References for SIDT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIDT1 Gene

Domains for SIDT1 Gene

Protein Domains for SIDT1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SIDT1_HUMAN
Family:
  • Belongs to the SID1 family.:
    • Q9NXL6
genes like me logo Genes that share domains with SIDT1: view

No data available for Gene Families for SIDT1 Gene

Function for SIDT1 Gene

Gene Ontology (GO) - Molecular Function for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SIDT1: view

miRNA for SIDT1 Gene

miRTarBase miRNAs that target SIDT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIDT1 Gene

Localization for SIDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIDT1 Gene COMPARTMENTS Subcellular localization image for SIDT1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIDT1: view

Pathways for SIDT1 Gene

SuperPathways for SIDT1 Gene

No Data Available

Interacting Proteins for SIDT1 Gene

Gene Ontology (GO) - Biological Process for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033227 dsRNA transport IEA --
genes like me logo Genes that share ontologies with SIDT1: view

No data available for Pathways by source for SIDT1 Gene

Transcripts for SIDT1 Gene

Unigene Clusters for SIDT1 Gene

SID1 transmembrane family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for SIDT1 Gene

GeneLoc Exon Structure for
SIDT1
ECgene alternative splicing isoforms for
SIDT1

Expression for SIDT1 Gene

mRNA expression in normal human tissues for SIDT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SIDT1 Gene

SOURCE GeneReport for Unigene cluster for SIDT1 Gene Hs.591291

genes like me logo Genes that share expressions with SIDT1: view

Orthologs for SIDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIDT1 36
  • 99.31 (n)
  • 99.64 (a)
SIDT1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIDT1 36
  • 89.02 (n)
  • 91.62 (a)
SIDT1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIDT1 36
  • 89.74 (n)
  • 92.84 (a)
SIDT1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sidt1 36
  • 87.39 (n)
  • 91.94 (a)
Sidt1 16
Sidt1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIDT1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sidt1 36
  • 87.16 (n)
  • 91.55 (a)
chicken
(Gallus gallus)
Aves SIDT1 36
  • 77.74 (n)
  • 82.83 (a)
SIDT1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIDT1 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt1 36
  • 70.24 (n)
  • 70.92 (a)
worm
(Caenorhabditis elegans)
Secernentea chup-1 37
  • 34 (a)
ManyToMany
sid-1 37
  • 22 (a)
ManyToMany
Species with no ortholog for SIDT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SIDT1 Gene

ENSEMBL:
Gene Tree for SIDT1 (if available)
TreeFam:
Gene Tree for SIDT1 (if available)

Paralogs for SIDT1 Gene

Paralogs for SIDT1 Gene

Selected SIMAP similar genes for SIDT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIDT1: view

Variants for SIDT1 Gene

Sequence variations from dbSNP and Humsavar for SIDT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs950356 -- 113,615,575(+) ATGAT(A/T)GTTTC intron-variant
rs950357 -- 113,615,386(+) TGGGC(A/C)GACCC intron-variant
rs1398733 -- 113,547,563(-) CTTGT(A/G)CAAAA intron-variant
rs1513287 -- 113,553,361(-) CCAGC(C/T)TTTTA intron-variant
rs1513288 -- 113,546,228(-) TCAGA(A/G)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIDT1 Gene

Variant ID Type Subtype PubMed ID
dgv5232n71 CNV Loss 21882294
nsv524086 CNV Loss 19592680
esv2265706 CNV Deletion 18987734

Relevant External Links for SIDT1 Gene

HapMap Linkage Disequilibrium report
SIDT1

Disorders for SIDT1 Gene

Relevant External Links for SIDT1

Genetic Association Database (GAD)
SIDT1
Human Genome Epidemiology (HuGE) Navigator
SIDT1
genes like me logo Genes that share disorders with SIDT1: view

No data available for UniProtKB/Swiss-Prot for SIDT1 Gene

Publications for SIDT1 Gene

  1. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. (PMID: 15850781) Duxbury M.S. … Whang E.E. (Biochem. Biophys. Res. Commun. 2005) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. (PMID: 22174421) Elhassan M.O. … Duxbury M.S. (J. Biol. Chem. 2012) 3
  5. Preparation and characterization of the extracellular domain of human Sid-1. (PMID: 22509261) Pratt A.J. … MacRae I.J. (PLoS ONE 2012) 3

Products for SIDT1 Gene

  • antibodies-online peptides for SIDT1
  • antibodies-online antibodies for SIDT1
  • antibodies-online kits for SIDT1

Sources for SIDT1 Gene

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