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Aliases for SIDT1 Gene

Aliases for SIDT1 Gene

  • SID1 Transmembrane Family Member 1 2 3 5
  • SID1 Transmembrane Family, Member 1 2
  • SID-1 3
  • SID1 3

External Ids for SIDT1 Gene

Previous GeneCards Identifiers for SIDT1 Gene

  • GC03P114734
  • GC03P113251
  • GC03P110626

Summaries for SIDT1 Gene

GeneCards Summary for SIDT1 Gene

SIDT1 (SID1 Transmembrane Family Member 1) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT1 Gene

Genomics for SIDT1 Gene

Regulatory Elements for SIDT1 Gene

Enhancers for SIDT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F113531 0.9 ENCODE 36.7 +0.9 870 4.3 TBP PKNOX1 WRNIP1 SIN3A YBX1 BMI1 RAD21 ZBTB40 YY1 GLIS2 SIDT1 CFAP44 CCDC191 GC03P113536
GH03F113557 0.6 ENCODE 20 +25.4 25364 0.7 SOX13 CTCF SIX4 PKNOX1 ATF1 SAP130 RAD21 RARA ZNF7 TEAD3 SIDT1 SIDT1-AS1 SPICE1 CFAP44 GC03P113536
GH03F113560 1.1 FANTOM5 Ensembl 19.7 +28.6 28605 1.0 CTCF RFX1 L3MBTL2 CHD1 BMI1 FOXP2 RAD21 CREM MGA SIDT1 SIDT1-AS1 SPICE1 USF3 GC03P113536
GH03F113606 1.1 Ensembl ENCODE 12.1 +74.9 74859 1.5 PKNOX1 MXI1 TBL1XR1 TEAD4 JUNB EP300 GABPA RELA EGR1 EED SIDT1 GC03M113598 RN7SL767P
GH03F113436 0.5 ENCODE 12.1 -95.1 -95086 1.7 SIDT1 CFAP44 ENSG00000283241
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIDT1 on UCSC Golden Path with GeneCards custom track

Promoters for SIDT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001371032 704 2001 TBP WRNIP1 SIN3A YBX1 BMI1 RAD21 ZBTB40 YY1 GLIS2 CBX5

Genomic Location for SIDT1 Gene

113,532,296 bp from pter
113,632,097 bp from pter
99,802 bases
Plus strand

Genomic View for SIDT1 Gene

Genes around SIDT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT1 Gene

Proteins for SIDT1 Gene

  • Protein details for SIDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SID1 transmembrane family member 1
    Protein Accession:
    Secondary Accessions:
    • Q17RR4

    Protein attributes for SIDT1 Gene

    827 amino acids
    Molecular mass:
    93839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIDT1 Gene


neXtProt entry for SIDT1 Gene

Post-translational modifications for SIDT1 Gene

  • Glycosylation at Asn 57, Asn 67, Asn 83, Asn 136, Asn 282, Asn 471, Asn 567, and Asn 764
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIDT1 Gene

Domains & Families for SIDT1 Gene

Protein Domains for SIDT1 Gene


Suggested Antigen Peptide Sequences for SIDT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SID1 family.
  • Belongs to the SID1 family.
genes like me logo Genes that share domains with SIDT1: view

No data available for Gene Families for SIDT1 Gene

Function for SIDT1 Gene

Gene Ontology (GO) - Molecular Function for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SIDT1: view
genes like me logo Genes that share phenotypes with SIDT1: view

Animal Models for SIDT1 Gene

MGI Knock Outs for SIDT1:

Animal Model Products

miRNA for SIDT1 Gene

miRTarBase miRNAs that target SIDT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIDT1 Gene

Localization for SIDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SIDT1 Gene COMPARTMENTS Subcellular localization image for SIDT1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIDT1: view

Pathways & Interactions for SIDT1 Gene

SuperPathways for SIDT1 Gene

No Data Available

Interacting Proteins for SIDT1 Gene

Selected Interacting proteins: Q9NXL6-SIDT1_HUMAN for SIDT1 Gene via IID

Gene Ontology (GO) - Biological Process for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033227 dsRNA transport IEA --
genes like me logo Genes that share ontologies with SIDT1: view

No data available for Pathways by source and SIGNOR curated interactions for SIDT1 Gene

Transcripts for SIDT1 Gene

Unigene Clusters for SIDT1 Gene

SID1 transmembrane family, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP3: -
SP4: -
SP5: -

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -

Relevant External Links for SIDT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIDT1 Gene

mRNA expression in normal human tissues for SIDT1 Gene

Protein differential expression in normal tissues from HIPED for SIDT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.1) and Breast (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIDT1 Gene

Protein tissue co-expression partners for SIDT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIDT1 Gene:


SOURCE GeneReport for Unigene cluster for SIDT1 Gene:

genes like me logo Genes that share expression patterns with SIDT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIDT1 Gene

Orthologs for SIDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIDT1 34 35
  • 99.31 (n)
(Canis familiaris)
Mammalia SIDT1 34 35
  • 89.74 (n)
(Bos Taurus)
Mammalia SIDT1 34 35
  • 89.02 (n)
(Monodelphis domestica)
Mammalia SIDT1 35
  • 89 (a)
(Mus musculus)
Mammalia Sidt1 34 16 35
  • 87.39 (n)
(Rattus norvegicus)
Mammalia Sidt1 34
  • 87.16 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 75 (a)
-- 35
  • 52 (a)
(Gallus gallus)
Aves SIDT1 34 35
  • 77.74 (n)
(Anolis carolinensis)
Reptilia SIDT1 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt1 34
  • 70.24 (n)
(Caenorhabditis elegans)
Secernentea chup-1 35
  • 34 (a)
sid-1 35
  • 22 (a)
Species where no ortholog for SIDT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SIDT1 Gene

Gene Tree for SIDT1 (if available)
Gene Tree for SIDT1 (if available)

Paralogs for SIDT1 Gene

Paralogs for SIDT1 Gene

(1) SIMAP similar genes for SIDT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIDT1: view

Variants for SIDT1 Gene

Sequence variations from dbSNP and Humsavar for SIDT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs531258462 Likely benign 113,623,530(+) TCATG(A/G)AGGTA nc-transcript-variant, reference, missense
rs10534213 -- 113,541,112(+) TTCTA(-/ATAT)ATATA intron-variant
rs10804510 -- 113,621,853(+) TGTAA(A/T)TGTTT intron-variant
rs111268863 -- 113,626,037(+) CTGGA(C/T)GTTCA intron-variant
rs111275644 -- 113,619,764(+) TTATT(A/G)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIDT1 Gene

Variant ID Type Subtype PubMed ID
esv2265706 CNV deletion 18987734
esv3597441 CNV loss 21293372
nsv1013506 CNV gain 25217958
nsv524086 CNV loss 19592680

Variation tolerance for SIDT1 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.75; 83.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIDT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT1 Gene

Disorders for SIDT1 Gene

Relevant External Links for SIDT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIDT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIDT1 Gene

Publications for SIDT1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. (PMID: 15850781) Duxbury M.S. … Whang E.E. (Biochem. Biophys. Res. Commun. 2005) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  5. Preparation and characterization of the extracellular domain of human Sid-1. (PMID: 22509261) Pratt A.J. … MacRae I.J. (PLoS ONE 2012) 3 64

Products for SIDT1 Gene

Sources for SIDT1 Gene

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