SIDT1 Gene
protein-coding GIFtS: 44
GCID: GC03P113251
|
|
SID1 transmembrane family, member 1
| |
Aliases
for SIDT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SID1 Transmembrane Family, Member 11 2 | | SID-11 2 | | FLJ201741 | | B830021E24Rik2 | | SID12 | | SID1 Transmembrane Family Member 12 |
Export aliases for SIDT1 gene to outside databasesPrevious GC identifers: GC03P114734 GC03P110626 |
Summaries
for SIDT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SIDT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIDT1 gene promoter:
RORalpha1 TBP C/EBPbeta POU2F1 AML1a POU2F1a HTF C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIDT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIDT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.2 Ensembl cytogenetic band: 3q13.2 HGNC cytogenetic band: 3q13.31SIDT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P113251: view genomic region
(about GC identifiers)
Start:
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113,251,143 bp from pter |
End:
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113,348,425 bp from pter |
Size:
|
97,283 bases |
Orientation:
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plus strand |
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Proteins
for SIDT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIDT1_HUMAN, Q9NXL6 (See
protein sequence)Recommended Name: SID1 transmembrane family member 1 precursor Size: 827 amino acids; 93839 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q17RR4Alternative splicing: 2 isoforms: Q9NXL6-1 Q9NXL6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIDT1: NX_Q9NXL6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXL6
SIDT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060169.2
ENSEMBL proteins: ENSP00000264852 ENSP00000377416
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SIDT1 for ontologies About GeneDecksing
SIDT1 Antibody Products:
Assay Products for SIDT1: |
Protein
Domains /
Families
for SIDT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIDT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXL6ProtoNet protein and cluster: Q9NXL6 UniProtKB/Swiss-Prot: SIDT1_HUMAN, Q9NXL6Similarity: Belongs to the SID1 family |
Function
for SIDT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIDT1 (NM_017699) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIDT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIDT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIDT1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051033 | RNA transmembrane transporter activity |
IEA | -- |
SIDT1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SIDT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIDT1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016246 | RNA interference |
IEA | -- | | GO:0033227 | dsRNA transport |
IEA | -- |
SIDT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIDT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIDT1
Search CenterWatch for drugs/clinical trials and news about SIDT1
|
Transcripts
for SIDT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIDT1 gene: NM_017699.2 Unigene Cluster for SIDT1: SID1 transmembrane family, member 1 Hs.591291 [show with all ESTs]Unigene Representative Sequence: NM_01769912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264852(uc003eak.3 uc021xcn.1 uc011big.2 uc011bii.2)
ENST00000491730 ENST00000483946 ENST00000488390 ENST00000480746 ENST00000468728
ENST00000463226 ENST00000465803 ENST00000492863 ENST00000481891 ENST00000498152
ENST00000393830(uc011bif.1 uc021xcq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIDT1 (NM_017699) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIDT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIDT1 |
Additional cDNA sequence: AK295938.1 AK303385.1 BC117222.1 BC143776.1 BC143778.1 6 DOTS entries: DT.427797 DT.120921556 DT.120921570 DT.95365063 DT.91740728 DT.91863290 24/30 AceView cDNA sequences (see all 30): NM_017699 AI275725 BG661293 CF136238 BF590534 BE061660 AK000181 AA278917 AI287788 BF436981 BG403056 AV731066 CA487695 BX504328 BE748640 BM856233 CD521416 AI004220 H91646 BE061675 AW505388 BG484269 BE748094 T51446
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SIDT1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
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| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b |
|---|
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| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIDT1
|
Expression
for SIDT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIDT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAAACTT
About this image
See SIDT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIDT1
SOURCE GeneReport for Unigene cluster: Hs.591291
SABiosciences Custom PCR Arrays for SIDT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIDT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIDT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIDT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIDT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIDT1 |
Orthologs
for SIDT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SIDT1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SIDT1 (if available)
TreeFam Gene Tree for SIDT1 (if available) |
Paralogs
for SIDT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIDT1 gene
- SIDT22
1 SIMAP similar gene for SIDT1 using alignment to 2 protein entries: SIDT1_HUMAN (see all proteins):SIDT2
SIDT1 for paralogs About GeneDecksing
|
Genomic Variants
for SIDT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIDT1 (113251143 - 113348425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SIDT1
1 Indel: 46273 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIDT1 |
|
Disorders
/ Diseases
for SIDT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SIDT1 for disorders About MalaCards
SIDT1 for disorders About GeneDecksing
OMIM gene information: 606816
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: SIDT1 (1 document)
Export disorders for SIDT1 gene to outside databases
|
Publications
for SIDT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIDT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIDT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. (PubMed id 15850781)1, 9 Duxbury M.S....Whang E.E. (2005)
- Preparation and characterization of the extracellular domain of human Sid-1. (PubMed id 22509261)1 Pratt A.J....MacRae I.J. (2012)
- Homo sapiens systemic RNA interference-defective-1 tra nsmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. (PubMed id 22174421)1 Elhassan M.O....Duxbury M.S. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
|
External Searches for SIDT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIDT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIDT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIDT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIDT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SIDT1 gene:
Search GeneIP for patents involving SIDT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIDT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIDT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIDT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIDT1 | | | OriGene Protein Over-expression Lysate for SIDT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIDT1 | | OriGene 3'-UTR Clone for SIDT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIDT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIDT1 | | OriGene Custom Protein Services for SIDT1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIDT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIDT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIDT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIDT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIDT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIDT1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SIDT1 |
| |  |  |  |  | | | | |
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 | | | SIDT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIDT1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SIDT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIDT1 |
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