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Aliases for SIDT1 Gene

Aliases for SIDT1 Gene

  • SID1 Transmembrane Family, Member 1 2 3
  • SID1 Transmembrane Family Member 1 3
  • B830021E24Rik 3
  • SID-1 3
  • SID1 3

External Ids for SIDT1 Gene

Previous GeneCards Identifiers for SIDT1 Gene

  • GC03P114734
  • GC03P113251
  • GC03P110626

Summaries for SIDT1 Gene

GeneCards Summary for SIDT1 Gene

SIDT1 (SID1 Transmembrane Family, Member 1) is a Protein Coding gene. GO annotations related to this gene include RNA transmembrane transporter activity. An important paralog of this gene is SIDT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIDT1 Gene

Genomics for SIDT1 Gene

Regulatory Elements for SIDT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIDT1 Gene

113,532,296 bp from pter
113,629,578 bp from pter
97,283 bases
Plus strand

Genomic View for SIDT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIDT1 Gene

Proteins for SIDT1 Gene

  • Protein details for SIDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SID1 transmembrane family member 1
    Protein Accession:
    Secondary Accessions:
    • Q17RR4

    Protein attributes for SIDT1 Gene

    827 amino acids
    Molecular mass:
    93839 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIDT1 Gene


neXtProt entry for SIDT1 Gene

Proteomics data for SIDT1 Gene at MOPED

Post-translational modifications for SIDT1 Gene

  • Glycosylation at Asn57, Asn67, Asn83, Asn136, Asn282, Asn471, Asn567, and Asn764
  • Modification sites at PhosphoSitePlus

Other Protein References for SIDT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIDT1 Gene

Domains for SIDT1 Gene

Protein Domains for SIDT1 Gene


Suggested Antigen Peptide Sequences for SIDT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NXL6
  • Belongs to the SID1 family.
genes like me logo Genes that share domains with SIDT1: view

No data available for Gene Families for SIDT1 Gene

Function for SIDT1 Gene

Gene Ontology (GO) - Molecular Function for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051033 RNA transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SIDT1: view

Animal Model Products

miRNA for SIDT1 Gene

miRTarBase miRNAs that target SIDT1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIDT1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIDT1 Gene

Localization for SIDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIDT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SIDT1 Gene COMPARTMENTS Subcellular localization image for SIDT1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIDT1: view

Pathways for SIDT1 Gene

SuperPathways for SIDT1 Gene

No Data Available

Interacting Proteins for SIDT1 Gene

Gene Ontology (GO) - Biological Process for SIDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033227 dsRNA transport IEA --
genes like me logo Genes that share ontologies with SIDT1: view

No data available for Pathways by source for SIDT1 Gene

Transcripts for SIDT1 Gene

Unigene Clusters for SIDT1 Gene

SID1 transmembrane family, member 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIDT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIDT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - -
SP3: -
SP4: -
SP5: -

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b
SP1: -

Relevant External Links for SIDT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIDT1 Gene

mRNA expression in normal human tissues for SIDT1 Gene

Protein differential expression in normal tissues for SIDT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.1) and Breast (10.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SIDT1 Gene

SOURCE GeneReport for Unigene cluster for SIDT1 Gene Hs.591291

genes like me logo Genes that share expressions with SIDT1: view

Expression partners for SIDT1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIDT1 Gene

Orthologs for SIDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIDT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIDT1 35
  • 89.02 (n)
  • 91.62 (a)
SIDT1 36
  • 85 (a)
(Canis familiaris)
Mammalia SIDT1 35
  • 89.74 (n)
  • 92.84 (a)
SIDT1 36
  • 92 (a)
(Mus musculus)
Mammalia Sidt1 35
  • 87.39 (n)
  • 91.94 (a)
Sidt1 16
Sidt1 36
  • 91 (a)
(Pan troglodytes)
Mammalia SIDT1 35
  • 99.31 (n)
  • 99.64 (a)
SIDT1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sidt1 35
  • 87.16 (n)
  • 91.55 (a)
(Monodelphis domestica)
Mammalia SIDT1 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 52 (a)
-- 36
  • 75 (a)
(Gallus gallus)
Aves SIDT1 35
  • 77.74 (n)
  • 82.83 (a)
SIDT1 36
  • 81 (a)
(Anolis carolinensis)
Reptilia SIDT1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sidt1 35
  • 70.24 (n)
  • 70.92 (a)
(Caenorhabditis elegans)
Secernentea chup-1 36
  • 34 (a)
sid-1 36
  • 22 (a)
Species with no ortholog for SIDT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SIDT1 Gene

Gene Tree for SIDT1 (if available)
Gene Tree for SIDT1 (if available)

Paralogs for SIDT1 Gene

Paralogs for SIDT1 Gene

Selected SIMAP similar genes for SIDT1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIDT1: view

Variants for SIDT1 Gene

Sequence variations from dbSNP and Humsavar for SIDT1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs950356 -- 113,615,575(+) ATGAT(A/T)GTTTC intron-variant
rs950357 -- 113,615,386(+) TGGGC(A/C)GACCC intron-variant
rs1398733 -- 113,547,563(-) CTTGT(A/G)CAAAA intron-variant
rs1513287 -- 113,553,361(-) CCAGC(C/T)TTTTA intron-variant
rs1513288 -- 113,546,228(-) TCAGA(A/G)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIDT1 Gene

Variant ID Type Subtype PubMed ID
dgv5232n71 CNV Loss 21882294
nsv524086 CNV Loss 19592680
esv2265706 CNV Deletion 18987734

Relevant External Links for SIDT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIDT1 Gene

Disorders for SIDT1 Gene

Relevant External Links for SIDT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SIDT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SIDT1 Gene

Publications for SIDT1 Gene

  1. RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. (PMID: 15850781) Duxbury M.S. … Whang E.E. (Biochem. Biophys. Res. Commun. 2005) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance. (PMID: 22174421) Elhassan M.O. … Duxbury M.S. (J. Biol. Chem. 2012) 3
  5. Preparation and characterization of the extracellular domain of human Sid-1. (PMID: 22509261) Pratt A.J. … MacRae I.J. (PLoS ONE 2012) 3

Products for SIDT1 Gene

Sources for SIDT1 Gene

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