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Aliases for SIAH3 Gene

Aliases for SIAH3 Gene

  • Siah E3 Ubiquitin Protein Ligase Family Member 3 2 3
  • Siah-3 3 4
  • Seven In Absentia Homolog 3 (Drosophila) 2

External Ids for SIAH3 Gene

Previous GeneCards Identifiers for SIAH3 Gene

  • GC13M045252
  • GC13M046353
  • GC13M027151

Summaries for SIAH3 Gene

GeneCards Summary for SIAH3 Gene

SIAH3 (Siah E3 Ubiquitin Protein Ligase Family Member 3) is a Protein Coding gene. An important paralog of this gene is SIAH1.

UniProtKB/Swiss-Prot for SIAH3 Gene

  • Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIAH3 Gene

Genomics for SIAH3 Gene

Regulatory Elements for SIAH3 Gene

Genomic Location for SIAH3 Gene

Chromosome:
13
Start:
45,777,243 bp from pter
End:
45,851,736 bp from pter
Size:
74,494 bases
Orientation:
Minus strand

Genomic View for SIAH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SIAH3 Gene

Proteins for SIAH3 Gene

  • Protein details for SIAH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW03-SIAH3_HUMAN
    Recommended name:
    Seven in absentia homolog 3
    Protein Accession:
    Q8IW03
    Secondary Accessions:
    • B7ZBP0
    • Q8N8M6

    Protein attributes for SIAH3 Gene

    Size:
    269 amino acids
    Molecular mass:
    30660 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41372.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04809.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 13 and 19.; Evidence={ECO:0000305};

neXtProt entry for SIAH3 Gene

Proteomics data for SIAH3 Gene at MOPED

Post-translational modifications for SIAH3 Gene

No Post-translational modifications

Other Protein References for SIAH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIAH3 Gene

Domains & Families for SIAH3 Gene

Protein Domains for SIAH3 Gene

Suggested Antigen Peptide Sequences for SIAH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW03

UniProtKB/Swiss-Prot:

SIAH3_HUMAN :
  • Belongs to the SINA (Seven in absentia) family.
  • Contains 1 SIAH-type zinc finger.
Family:
  • Belongs to the SINA (Seven in absentia) family.
Similarity:
  • Contains 1 SIAH-type zinc finger.
genes like me logo Genes that share domains with SIAH3: view

No data available for Gene Families for SIAH3 Gene

Function for SIAH3 Gene

Molecular function for SIAH3 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.

Gene Ontology (GO) - Molecular Function for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with SIAH3: view

Phenotypes for SIAH3 Gene

genes like me logo Genes that share phenotypes with SIAH3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIAH3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SIAH3 Gene

Localization for SIAH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIAH3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIAH3 Gene COMPARTMENTS Subcellular localization image for SIAH3 gene
Compartment Confidence
mitochondrion 4
nucleus 2

Gene Ontology (GO) - Cellular Components for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IDA 24270810
genes like me logo Genes that share ontologies with SIAH3: view

Pathways & Interactions for SIAH3 Gene

SuperPathways for SIAH3 Gene

No Data Available

Interacting Proteins for SIAH3 Gene

Gene Ontology (GO) - Biological Process for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0006915 apoptotic process IBA --
GO:0007275 multicellular organismal development IEA --
GO:0031647 regulation of protein stability IMP 24270810
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with SIAH3: view

No data available for Pathways by source and SIGNOR curated interactions for SIAH3 Gene

Drugs & Compounds for SIAH3 Gene

No Compound Related Data Available

Transcripts for SIAH3 Gene

mRNA/cDNA for SIAH3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIAH3 Gene

Siah E3 ubiquitin protein ligase family member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIAH3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIAH3 Gene

No ASD Table

Relevant External Links for SIAH3 Gene

GeneLoc Exon Structure for
SIAH3
ECgene alternative splicing isoforms for
SIAH3

Expression for SIAH3 Gene

mRNA expression in normal human tissues for SIAH3 Gene

mRNA differential expression in normal tissues according to GTEx for SIAH3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.9) and Brain - Anterior cingulate cortex (BA24) (x4.5).

SOURCE GeneReport for Unigene cluster for SIAH3 Gene Hs.368483

genes like me logo Genes that share expression patterns with SIAH3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SIAH3 Gene

Orthologs for SIAH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIAH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIAH3 35
  • 83.71 (n)
  • 78.95 (a)
-- 36
  • 33 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SIAH3 35
  • 90.26 (n)
  • 95.11 (a)
SIAH3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siah3 35
  • 85.41 (n)
  • 90.57 (a)
Siah3 16
Siah3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIAH3 35
  • 99.26 (n)
  • 98.88 (a)
SIAH3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Siah3 35
  • 85.53 (n)
  • 89.81 (a)
oppossum
(Monodelphis domestica)
Mammalia SIAH3 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIAH3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIAH3 35
  • 78.1 (n)
  • 80.17 (a)
SIAH3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIAH3 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siah3 35
  • 68.35 (n)
  • 72.57 (a)
zebrafish
(Danio rerio)
Actinopterygii siah2l 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sina 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea siah-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8769 36
  • 41 (a)
OneToMany
Species with no ortholog for SIAH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIAH3 Gene

ENSEMBL:
Gene Tree for SIAH3 (if available)
TreeFam:
Gene Tree for SIAH3 (if available)

Paralogs for SIAH3 Gene

Paralogs for SIAH3 Gene

(2) SIMAP similar genes for SIAH3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIAH3 Gene

genes like me logo Genes that share paralogs with SIAH3: view

Variants for SIAH3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIAH3 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
esv2747353 CNV Deletion 23290073
nsv1024 CNV Loss 18451855
nsv527222 CNV Gain 19592680
nsv832597 CNV Loss 17160897

Variation tolerance for SIAH3 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIAH3 Gene

HapMap Linkage Disequilibrium report
SIAH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SIAH3 Gene

Disorders for SIAH3 Gene

Relevant External Links for SIAH3

Genetic Association Database (GAD)
SIAH3
Human Genome Epidemiology (HuGE) Navigator
SIAH3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIAH3
genes like me logo Genes that share disorders with SIAH3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIAH3 Gene

Publications for SIAH3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for SIAH3 Gene

Sources for SIAH3 Gene

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