SIAH3 Gene
protein-coding GIFtS: 37
GCID: GC13M046353
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siah E3 ubiquitin protein ligase family member 3(Previous name: seven in absentia homolog 3 (Drosophila) )
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Aliases
for SIAH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Siah E3 Ubiquitin Protein Ligase Family Member 31 2 | | FLJ392031 | | Seven In Absentia Homolog 3 (Drosophila)1 | | Seven In Absentia Homolog 32 | | Siah-33 | | Siah-33 |
Export aliases for SIAH3 gene to outside databasesPrevious GC identifers: GC13M045252 GC13M027151 |
Summaries
for SIAH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SIAH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIAH3 gene promoter:
E2F-3a E2F-4 E2F-5 GATA-3 POU3F2 (N-Oct-5a) E2F-2 POU3F2 GATA-2 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIAH3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIAH3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.13 Ensembl cytogenetic band: 13q14.13 HGNC cytogenetic band: 13q14.12SIAH3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M046353: view genomic region
(about GC identifiers)
Start:
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46,353,363 bp from pter |
End:
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46,425,871 bp from pter |
Size:
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72,509 bases |
Orientation:
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minus strand |
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Proteins
for SIAH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIAH3_HUMAN, Q8IW03 (See
protein sequence)Recommended Name: Seven in absentia homolog 3 Size: 269 amino acids; 30660 Da
Sequence caution: Sequence=AAH41372.2; Type=Erroneous initiation; Sequence=BAC04809.1; Type=Miscellaneous discrepancy;Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 13 and 19;
Secondary accessions: B7ZBP0 Q8N8M6Explore the universe of human proteins at neXtProt for SIAH3: NX_Q8IW03
SIAH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_942146.2
ENSEMBL proteins: ENSP00000383256
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SIAH3 for ontologies About GeneDecksing
SIAH3 Antibody Products:
Assay Products for SIAH3: |
Protein
Domains /
Families
for SIAH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIAH3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IW03ProtoNet protein and cluster: Q8IW03 UniProtKB/Swiss-Prot: SIAH3_HUMAN, Q8IW03Similarity: Belongs to the SINA (Seven in absentia) familySimilarity: Contains 1 SIAH-type zinc finger |
Function
for SIAH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIAH3 (NM_198849) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIAH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
SIAH3 for ontologies About GeneDecksing
|
Pathways & Interactions
for SIAH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIAH3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- |
SIAH3 for ontologies About GeneDecksing
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Drugs & Compounds
for SIAH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIAH3
Search CenterWatch for drugs/clinical trials and news about SIAH3
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Transcripts
for SIAH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIAH3 gene: NM_198849.2 Unigene Cluster for SIAH3: Siah E3 ubiquitin protein ligase family member 3 Hs.368483 [show with all ESTs]Unigene Representative Sequence: BC0413722 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471241 ENST00000400405(uc001vap.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIAH3 (NM_198849) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIAH3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH3 |
Additional cDNA sequence: AK125411.1 BC041372.2 1 DOTS entry: DT.95328392 10 AceView cDNA sequences: BC041372 AK125411 AA442387 BU740990 AW293773 R40294 BI551601 AK096522 BM703200 NM_198849
GeneLoc Exon Structure
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Expression
for SIAH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIAH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACACAAG
About this image
See SIAH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIAH3
SOURCE GeneReport for Unigene cluster: Hs.368483
SABiosciences Custom PCR Arrays for SIAH3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIAH3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIAH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIAH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIAH3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH3 |
Orthologs
for SIAH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SIAH3 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SIAH3 (if available)
TreeFam Gene Tree for SIAH3 (if available) |
Paralogs
for SIAH3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIAH3 gene
- SIAH22 SIAH12
2 SIMAP similar genes for SIAH3 using alignment to 1 protein entry: SIAH3_HUMAN:SIAH1 SIAH2
SIAH3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIAH3
PGOHUM00000243486
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Genomic Variants
for SIAH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIAH3 (46353363 - 46425871 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SIAH3
1 CNV: 4802 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIAH3 |
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Disorders
/ Diseases
for SIAH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SIAH3 for disorders About MalaCards
SIAH3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SIAH3 (1 document)
Export disorders for SIAH3 gene to outside databases
|
Publications
for SIAH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIAH3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIAH3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for SIAH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SIAH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SIAH3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIAH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIAH3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SIAH3 gene:
Search GeneIP for patents involving SIAH3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIAH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIAH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIAH3 | | | OriGene Protein Over-expression Lysate for SIAH3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIAH3 | | OriGene 3'-UTR Clone for SIAH3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIAH3 | | OriGene Custom Protein Services for SIAH3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIAH3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIAH3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIAH3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIAH3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIAH3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIAH3 |
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| | | | Search Tocris compounds for SIAH3 |
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 | | | SIAH3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH3 |
|  |  |  | | | | ThermoFisher Antibodies for SIAH3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH3 |
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