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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIAH3 Gene

protein-coding   GIFtS: 38
GCID: GC13M046353

Siah E3 Ubiquitin Protein Ligase Family Member 3

(Previous name: seven in absentia homolog 3 (Drosophila))
  Search for SIAH3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Siah E3 Ubiquitin Protein Ligase Family Member 31 2
Seven In Absentia Homolog 3 (Drosophila)1
Seven In Absentia Homolog 32
siah-32
Siah-33

External Ids:    HGNC: 305531   Entrez Gene: 2835142   Ensembl: ENSG000002154757   UniProtKB: Q8IW033   

Export aliases for SIAH3 gene to outside databases

Previous GC identifers: GC13M045252 GC13M027151


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SIAH3 Gene: 
SIAH3 (siah E3 ubiquitin protein ligase family member 3) is a protein-coding gene. GO annotations related to this gene include metal ion binding. An important paralog of this gene is SIAH2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIAH3 gene promoter:
         E2F-3a   E2F-4   E2F-5   GATA-3   POU3F2 (N-Oct-5a)   E2F-2   POU3F2   GATA-2   E2F-1   E2F   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SIAH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIAH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.13   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.12

SIAH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIAH3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M046353:  view genomic region     (about GC identifiers)

Start:
46,354,405 bp from pter      End:
46,425,871 bp from pter
Size:
71,467 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIAH3_HUMAN, Q8IW03 (See protein sequence)
Recommended Name: Seven in absentia homolog 3  
Size: 269 amino acids; 30660 Da
Sequence caution: Sequence=AAH41372.2; Type=Erroneous initiation; Sequence=BAC04809.1; Type=Miscellaneous
discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 13 and 19;
Secondary accessions: B7ZBP0 Q8N8M6

Explore the universe of human proteins at neXtProt for SIAH3: NX_Q8IW03

Explore proteomics data for SIAH3 at MOPED 

SIAH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SIAH3 Protein Expression

REFSEQ proteins: NP_942146.2  
ENSEMBL proteins: 
 ENSP00000383256  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

SIAH3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR008974 TRAF-like
 IPR018121 7-in-absentia-prot_TRAF-dom
 IPR004162 7-in-absentia-prot

Graphical View of Domain Structure for InterPro Entry Q8IW03

ProtoNet protein and cluster: Q8IW03

UniProtKB/Swiss-Prot: SIAH3_HUMAN, Q8IW03
Similarity: Belongs to the SINA (Seven in absentia) family
Similarity: Contains 1 SIAH-type zinc finger


SIAH3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0046872metal ion binding IEA--
     
SIAH3 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIAH3

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006511ubiquitin-dependent protein catabolic process IEA--
GO:0007275multicellular organismal development IEA--

SIAH3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for SIAH3

Search CenterWatch for drugs/clinical trials and news about SIAH3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIAH3 gene: 
NM_198849.2  

Unigene Cluster for SIAH3:

Siah E3 ubiquitin protein ligase family member 3
Hs.368483  [show with all ESTs]
Unigene Representative Sequence: BC041372
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000400405(uc001vap.3)
miRNA
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Additional mRNA sequence: 

AK125411.1 BC041372.2 

1 DOTS entry:

DT.95328392 

10 AceView cDNA sequences:

BC041372 AK125411 AA442387 BU740990 AW293773 NM_198849 AK096522 BM703200 
R40294 BI551601 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIAH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGACACAAG
SIAH3 Expression
About this image


See SIAH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIAH3

SOURCE GeneReport for Unigene cluster: Hs.368483
    SABiosciences Custom PCR Arrays for SIAH3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SIAH3 gene from 6/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Siah31 , 5 seven in absentia homolog 3 (Drosophila)1, 5 86.15(n)1
91.92(a)1
  14 (40.08 cM)5
3809181  NM_001128093.11  NP_001121565.11 
 754559825 
chicken
(Gallus gallus)
Aves SIAH31 seven in absentia homolog 3 (Drosophila) 78.37(n)
81.82(a)
  418849  XM_417044.3  XP_417044.1 
lizard
(Anolis carolinensis)
Reptilia SIAH26
Uncharacterized protein
47(a)
possible ortholog
3(18270308-18270966)
zebrafish
(Danio rerio)
Actinopterygii siah2l6
seven in absentia homolog 2 (Drosophila)-like
31(a)
possible ortholog
21(37619561-37678113)
fruit fly
(Drosophila melanogaster)
Insecta CG26816
sina6
(see all 3)
seven in absentia
(see all 3)
5(a)
32(a)
(see all 3)
possible ortholog
1 ↔ many
(see all 3)
X(2602717-2605701)
3L(16846851-16851812)
worm
(Caenorhabditis elegans)
Secernentea siah-16
E3 ubiquitin-protein ligase siah-1
20(a)
1 → many
IV(3744045-3747306)


ENSEMBL Gene Tree for SIAH3 (if available)
TreeFam Gene Tree for SIAH3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SIAH3 gene
SIAH22  SIAH12  
2 SIMAP similar genes for SIAH3 using alignment to 1 protein entry:     SIAH3_HUMAN:
SIAH1    SIAH2

SIAH3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SIAH3
PGOHUM00000243486


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1810 SNPs in SIAH3 are shown (see all 1810)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1150700041,2
C,F--46353930(+) ATCTAT/ATCCTA 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1822256391,2
--46354096(+) CCACAC/TCTCCT 1 -- ds50010--------
rs1875396441,2
--46354139(+) GATACC/TGGTAA 1 -- ds50010--------
rs740722601,2
C,F--46354166(+) AAGTGC/TGCTGT 1 -- ds50012Minor allele frequency- T:0.50WA CSA 4
rs1925756361,2
--46354181(+) CTAGGC/TCTTCT 1 -- ds50010--------
rs73254111,2
C,F,H--46354229(+) ACTCTA/TGCACC 1 -- ds500121Minor allele frequency- N:0.00NS EA NA WA CSA 948
rs1833753291,2
--46354240(+) TTGGTA/GTGAAT 1 -- ds50010--------
rs1887800441,2
--46354263(+) TCCCAA/GCGTTC 1 -- ds50010--------
rs1436106141,2
--46354364(+) CAGCCA/CACCCA 1 -- ds50010--------
rs596579331,2
C--46354405(+) AGTGC-/TTTTTT 1 -- ut312Minor allele frequency- T:0.00NA CSA 4

HapMap Linkage Disequilibrium report for SIAH3 (46354405 - 46425871 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for SIAH3:    About this table     
Variant IDTypeSubtypePubMed ID
dgv250e201CNV Deletion23290073
esv2747353CNV Deletion23290073
nsv1024CNV Loss18451855
nsv832597CNV Loss17160897
nsv527222CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIAH3 for disorders           About MalaCards

SIAH3 for disorders           About GeneDecksing

Genetic Association Database (GAD): SIAH3
Human Genome Epidemiology (HuGE) Navigator: SIAH3 (1 document)

Export disorders for SIAH3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SIAH3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIAH3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 283514 HGNC: 30553 AceView: LOC283514 Ensembl:ENSG00000215475 euGenes: HUgn283514
ECgene: SIAH3 H-InvDB: SIAH3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SIAH3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SIAH3 gene:
Search GeneIP for patents involving SIAH3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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