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Aliases for SIAH3 Gene

Aliases for SIAH3 Gene

  • Siah E3 Ubiquitin Protein Ligase Family Member 3 2 3
  • Siah-3 3 4
  • Seven In Absentia Homolog 3 (Drosophila) 2
  • Seven In Absentia Homolog 3 3

External Ids for SIAH3 Gene

Summaries for SIAH3 Gene

GeneCards Summary for SIAH3 Gene

SIAH3 (Siah E3 Ubiquitin Protein Ligase Family Member 3) is a Protein Coding gene. An important paralog of this gene is SIAH1.

UniProtKB/Swiss-Prot for SIAH3 Gene

  • Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIAH3 Gene

Genomics for SIAH3 Gene

Genomic Location for SIAH3 Gene

Start:
45,777,243 bp from pter
End:
45,851,736 bp from pter
Size:
74,494 bases
Orientation:
Minus strand

Genomic View for SIAH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIAH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIAH3 Gene

Regulatory Elements for SIAH3 Gene

Proteins for SIAH3 Gene

  • Protein details for SIAH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW03-SIAH3_HUMAN
    Recommended name:
    Seven in absentia homolog 3
    Protein Accession:
    Q8IW03
    Secondary Accessions:
    • B7ZBP0
    • Q8N8M6

    Protein attributes for SIAH3 Gene

    Size:
    269 amino acids
    Molecular mass:
    30660 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41372.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04809.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 13 and 19.; Evidence={ECO:0000305};

neXtProt entry for SIAH3 Gene

Proteomics data for SIAH3 Gene at MOPED

Post-translational modifications for SIAH3 Gene

No Post-translational modifications

Other Protein References for SIAH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIAH3 Gene

Domains for SIAH3 Gene

Protein Domains for SIAH3 Gene

Suggested Antigen Peptide Sequences for SIAH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW03

UniProtKB/Swiss-Prot:

SIAH3_HUMAN
Family:
  • Belongs to the SINA (Seven in absentia) family.:
    • Q8IW03
Similarity:
  • Contains 1 SIAH-type zinc finger.:
    • Q8IW03
genes like me logo Genes that share domains with SIAH3: view

No data available for Gene Families for SIAH3 Gene

Function for SIAH3 Gene

Molecular function for SIAH3 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.

Gene Ontology (GO) - Molecular Function for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SIAH3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIAH3 Gene

Localization for SIAH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIAH3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIAH3 Gene COMPARTMENTS Subcellular localization image for SIAH3 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SIAH3: view

Pathways for SIAH3 Gene

SuperPathways for SIAH3 Gene

No Data Available

Interacting Proteins for SIAH3 Gene

Gene Ontology (GO) - Biological Process for SIAH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with SIAH3: view

No data available for Pathways by source for SIAH3 Gene

Transcripts for SIAH3 Gene

mRNA/cDNA for SIAH3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIAH3 Gene

Siah E3 ubiquitin protein ligase family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIAH3 Gene

No ASD Table

Relevant External Links for SIAH3 Gene

GeneLoc Exon Structure for
SIAH3
ECgene alternative splicing isoforms for
SIAH3

Expression for SIAH3 Gene

mRNA expression in normal human tissues for SIAH3 Gene

mRNA differential expression in normal tissues according to GTEx for SIAH3 Gene

This gene is overexpressed in Brain - Cerebellum (4.9) and Brain - Anterior cingulate cortex (BA24) (4.5).

SOURCE GeneReport for Unigene cluster for SIAH3 Gene Hs.368483

genes like me logo Genes that share expressions with SIAH3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for SIAH3 Gene

Orthologs for SIAH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIAH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIAH3 35
  • 99.26 (n)
  • 98.88 (a)
SIAH3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 33 (a)
ManyToMany
SIAH3 35
  • 83.71 (n)
  • 78.95 (a)
dog
(Canis familiaris)
Mammalia SIAH3 35
  • 90.26 (n)
  • 95.11 (a)
SIAH3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Siah3 35
  • 85.41 (n)
  • 90.57 (a)
Siah3 16
Siah3 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIAH3 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIAH3 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Siah3 35
  • 85.53 (n)
  • 89.81 (a)
chicken
(Gallus gallus)
Aves SIAH3 35
  • 78.1 (n)
  • 80.17 (a)
SIAH3 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIAH3 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia siah3 35
  • 68.35 (n)
  • 72.57 (a)
zebrafish
(Danio rerio)
Actinopterygii siah2l 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sina 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea siah-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8769 36
  • 41 (a)
OneToMany
Species with no ortholog for SIAH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIAH3 Gene

ENSEMBL:
Gene Tree for SIAH3 (if available)
TreeFam:
Gene Tree for SIAH3 (if available)

Paralogs for SIAH3 Gene

Paralogs for SIAH3 Gene

Selected SIMAP similar genes for SIAH3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIAH3 Gene

genes like me logo Genes that share paralogs with SIAH3: view

Variants for SIAH3 Gene

Sequence variations from dbSNP and Humsavar for SIAH3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs719401 -- 45,807,789(+) ACATT(A/G)CATAT intron-variant
rs719402 -- 45,808,128(+) cacca(C/T)ggaaa intron-variant
rs943292 -- 45,780,781(-) CATCA(A/G)GTGGT utr-variant-3-prime
rs959475 -- 45,815,404(-) AGCCC(A/G)AAGAC intron-variant
rs970691 -- 45,829,855(-) CAAGC(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIAH3 Gene

Variant ID Type Subtype PubMed ID
dgv250e201 CNV Deletion 23290073
esv2747353 CNV Deletion 23290073
nsv1024 CNV Loss 18451855
nsv527222 CNV Gain 19592680
nsv832597 CNV Loss 17160897

Relevant External Links for SIAH3 Gene

HapMap Linkage Disequilibrium report
SIAH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIAH3 Gene

Disorders for SIAH3 Gene

Relevant External Links for SIAH3

Genetic Association Database (GAD)
SIAH3
Human Genome Epidemiology (HuGE) Navigator
SIAH3
genes like me logo Genes that share disorders with SIAH3: view

No data available for UniProtKB/Swiss-Prot for SIAH3 Gene

Publications for SIAH3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4

Products for SIAH3 Gene

Sources for SIAH3 Gene

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