SIAH1 Gene
protein-coding GIFtS: 65
GCID: GC16M048443
|
|
siah E3 ubiquitin protein ligase 1(Previous name: seven in absentia homolog 1 (Drosophila) )
| |
Aliases
for SIAH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Siah E3 Ubiquitin Protein Ligase 11 2 | | Siah-1a3 | | Seven In Absentia Homolog 12 3 | | EC 6.3.2.-3 | | HSIAH11 | | HUMSIAH3 | | Seven In Absentia Homolog 1 (Drosophila)1 | | Siah-13 | | SIAH1A2 | | Siah-1a3 | | E3 Ubiquitin-Protein Ligase SIAH12 | | EC 6.3.28 |
Export aliases for SIAH1 gene to outside databasesPrevious GC identifers: GC16M038809 GC16M048131 GC16M048172 GC16M046951 GC16M034285 |
Summaries
for SIAH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIAH1:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity ofthis ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulationof the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additionaltranscript variants, some encoding different isoforms and others that have not been fully characterized. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of targetproteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either throughdirect binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggersthe ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2,MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, thecytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motorprotein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) andSNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in manycellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation,spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperationwith PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH,mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradationof nuclear proteins
Gene Wiki entry for SIAH1
|
Genomic Views
for SIAH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIAH1 gene promoter:
MEF-2A Sp1 MEF-2 aMEF-2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIAH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIAH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12SIAH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M048443: view genomic region
(about GC identifiers)
Start:
|
48,390,275 bp from pter |
End:
|
48,482,313 bp from pter |
Size:
|
92,039 bases |
Orientation:
|
minus strand |
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Proteins
for SIAH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase SIAH1 Size: 282 amino acids; 31123 Da
Subunit: Homodimer. Interacts with group 1 glutamate receptors GRM1 and GRM5. Interacts with DAB1, which may inhibitits activity. Interacts with UBE2E2. Interacts with PEG3. Interacts with GAPDH; leading to stabilize SIAH1 (Bysimilarity). Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interactswith UBE2I. Interacts with alpha-tubulin. Interacts with PEG10, which may inhibit its activity. Interacts withKHDRBS3. Interacts with SNCAIP and HIPK2
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
1 PDB 3D structure from  and Proteopedia  for SIAH1:2A25 (3D)
Secondary accessions: A0FKF3 O43269 Q49A58 Q92880Alternative splicing: 3 isoforms: Q8IUQ4-1 Q8IUQ4-2 Q8IUQ4-3 Explore the universe of human proteins at neXtProt for SIAH1: NX_Q8IUQ4
Post-translational modifications:
Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequentproteasomal degradation of HIPK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUQ4
4/15 DME Specific Peptides for SIAH1 (Q8IUQ4) (see all 15)
SIAH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006611.1 NP_003022.3
ENSEMBL proteins: ENSP00000456421 ENSP00000369343 ENSP00000349156 ENSP00000378214 ENSP00000457415 Reactome Protein details: Q8IUQ4
Human Recombinant Protein Products for SIAH1:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
SIAH1 for ontologies About GeneDecksing
SIAH1 Antibody Products:
Assay Products for SIAH1: |
Protein
Domains /
Families
for SIAH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIAH1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8IUQ4ProtoNet protein and cluster: Q8IUQ4 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activityDomain: The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrateproteins. It is related to the TRAF family (By similarity)Similarity: Belongs to the SINA (Seven in absentia) familySimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 1 SIAH-type zinc finger |
Function
for SIAH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SIAH1_HUMAN, Q8IUQ4Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of targetproteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester andthen directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either throughdirect binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggersthe ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2,MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, thecytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motorprotein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) andSNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in manycellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation,spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperationwith PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH,mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradationof nuclear proteinsEnzyme regulation: Inhibited by interaction with SNCAIP (isoform 2, but not isoform 1). May be inhibited by interactionwith PEG10Induction: May be induced by p53/TP53, suggesting that it may be required to modulate p53/TP53 response. The relevanceof such activity in vivo is however unclear and may not exist Genatlas biochemistry entry for SIAH1:Drosophila seven in absentia (sina) homolog 1,putatively involved in apoptosis and tumor suppression,also mediatingthrough RING finger ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SIAH1 for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Siah1a):
SIAH1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Siah1atm1Ddlb for SIAH1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SIAH1 (NM_001006610) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIAH1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH1 |
|
Pathways & Interactions
for SIAH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | | | 2 | Axon guidance | | | 3 | p53 signaling pathway | | | 4 | Netrin-1 signaling | | | 5 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SIAH1
1  GeneGo (Thomson Reuters) Pathway for SIAH1
1  BioSystems Pathway for SIAH1
3 
Reactome Pathways for SIAH1
3 
Kegg Pathways (Kegg details for SIAH1):
UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4Pathway: Protein modification; protein ubiquitination
SIAH1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIAH1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/134 Interacting proteins for SIAH1 (Q8IUQ41, 2, 3 ENSP000003491564) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
SIAH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIAH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SIAH1 for compounds About GeneDecksing
 Browse Tocris compounds for SIAH1
4 HMDB Compounds for SIAH1 About this table
1 Novoseek chemical compound relationship for SIAH1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nitric oxide |
0 |
6 |
16752048 (1), 15951807 (1) |
Search CenterWatch for drugs/clinical trials and news about SIAH1
|
Transcripts
for SIAH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIAH1 gene (2 alternative transcripts): NM_001006610.1 NM_003031.3 Unigene Cluster for SIAH1: Siah E3 ubiquitin protein ligase 1 Hs.706828 [show with all ESTs]Unigene Representative Sequence: BX6470648 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565620 ENST00000568007(uc002efl.3) ENST00000380006(uc021ths.1)
ENST00000356721(uc002efn.1) ENST00000394725(uc002efo.1) ENST00000563745
ENST00000573005 ENST00000567973
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIAH1 (NM_001006610) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIAH1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH1 |
Additional cDNA sequence: AB451253.1 AB451377.1 AK023458.1 AK094663.1 AK225895.1 AK313861.1 BC018193.1 BC035562.1 BC042550.1 BC044920.1 BX647064.1 EF026094.1 U63295.1 U76247.1 20 DOTS entries: DT.85105309 DT.91937961 DT.95181842 DT.91747164 DT.91759232 DT.95181829 DT.100765820 DT.100790999 DT.97833637 DT.91920720 DT.99955674 DT.100026014 DT.100685789 DT.100791002 DT.120721569 DT.75136444 DT.85105366 DT.120721489 DT.40203481 DT.95181828 24/228 AceView cDNA sequences (see all 228): BE676461 AV661355 AI972089 AL046386 AW768860 AA948066 AI560284 AW196873 CD679103 AA701951 AV649827 CR593197 AI368145 CK822873 CR607323 BF002338 BM670017 AI810587 AA447531 CR598465 AW167318 AA934422 AI248783 CA415438
GeneLoc Exon Structure
|
Expression
for SIAH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIAH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACAGTATTT
About this image
See SIAH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIAH1
SOURCE GeneReport for Unigene cluster: Hs.706828
UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4Tissue specificity: Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas
SABiosciences Expression via Pathway-Focused PCR Arrays including SIAH1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIAH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIAH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIAH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIAH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH1 |
Orthologs
for SIAH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SIAH1 gene from 8/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SIAH11 |
seven in absentia homolog 1 (Drosophila) |
90.31(n)
99.65(a) |
|
374076 XM_414105.2 XP_414105.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SIAH16 |
-- |
95(a) |
1 ↔ 1 |
LGc(2571329-2572501) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.20902 |
Xenopus laevis transcribed sequence with strong similarity more |
84.33(n) |
|
BU912024.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
idibd26352 |
idibd2635 |
77.31(n) |
|
80955 BC045870.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sina1 , 3 |
R7 cell fate commitment3
seven in absentia1 |
83(a)
(best of 2)3
64.56(n)1
79.18(a)1 |
|
3 73D33
398841 NM_057377.31 NP_476725.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y37E11AR.23
siah-11 |
Protein SIAH-11 |
67(a)3
58.5(n)1
63.4(a)1 |
|
IV(3744137-3747213)3
1771381 NM_068008.21 NP_500409.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G278801 |
E3 ubiquitin-protein ligase SINAT4 |
46.55(n)
38.82(a) |
|
828901 NM_118926.2 NP_194517.1 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 22) |
seven in absentia protein family domain containing...seven in absentia protein family domain containing...(see all 22) |
31(a)29(a)(see all 22) |
many ↔ manymany ↔ many(see all 22) |
2(1481233-1485113) 3(13632446-13636208) |
ENSEMBL Gene Tree for SIAH1 (if available)
TreeFam Gene Tree for SIAH1 (if available) |
Paralogs
for SIAH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIAH1 gene
- SIAH32 SIAH22
2 SIMAP similar genes for SIAH1 using alignment to 3 protein entries: SIAH1_HUMAN (see all proteins):SIAH2 SIAH3
SIAH1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SIAH1
PGOHUM00000241698
|
Genomic Variants
for SIAH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIAH1 (48390275 - 48482313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SIAH1
2 CNVs: 72582 4005 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIAH1 |
|
Disorders
/ Diseases
for SIAH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIAH1 for disorders About GeneDecksing
OMIM gene information: 602212
OMIM disorders: --
18  diseases for SIAH1: About MalaCardsparkinson's disease hypoxia adenomatous polyposis coli septic abortion
macular degeneration herpes simplex balanitis polyposis
hepatitis b hepatocellular carcinoma gastric cancer breast cancer
ataxia hepatitis carcinoma leukemia
neuronitis ischemia
2 Novoseek disease relationships for SIAH1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| parkinson disease |
45.8 |
2 |
16752048 (2) |
| tumors |
0 |
3 |
20144232 (3) |
Human Genome Epidemiology (HuGE) Navigator: SIAH1 (1 document)
Export disorders for SIAH1 gene to outside databases
|
Publications
for SIAH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIAH1 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with SIAH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of human homologs of the Drosophila seven in absentia (sina) gene. (PubMed id 9403064)1, 2, 3 Hu G.... Fearon E.R. (1997)
- Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. (PubMed id 9334332)1, 2, 3 Hu G.... Fearon E.R. (1997)
- SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. (PubMed id 15163637)1, 2, 9 Venables J.P.... Elliott D.J. (2004)
- Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. (PubMed id 16085652)1, 2, 9 Santelli E....Matsuzawa S. (2005)
- Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP). (PubMed id 12421809)1, 2, 9 Matsuzawa S....Ely K.R. (2003)
- Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta- inducible early gene-1 by human seven in absentia homologue. (PubMed id 12072443)1, 2, 9 Johnsen S.A....Spelsberg T.C. (2002)
- Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. (PubMed id 11389840)1, 2, 9 Liu J.... Matsunami N. (2001)
- Siah-1 facilitates ubiquitination and degradation of synphilin-1. (PubMed id 14506261)1, 2, 9 Nagano Y.... Matsumoto M. (2003)
- The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. (PubMed id 22483617)1, 2 Liu M....Zhou Q. (2012)
- Ubiquitin conjugase UBCH8 targets active FMS-like tyr osine kinase 3 for proteasomal degradation. (PubMed id 20508617)1, 2 Buchwald M....KrAomer O.H. (2010)
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External Searches for SIAH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing SIAH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SIAH1 gene
(According to HUGE)
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Specialized Databases showing SIAH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for SIAH1 gene:
Search GeneIP for patents involving SIAH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SIAH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for SIAH1 | | OriGene shRNA RFP for SIAH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIAH1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIAH1 | | | OriGene Protein Over-expression Lysate for SIAH1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SIAH1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIAH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  |  |  |  | | | | | | Recombinant Protein for SIAH1 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAH1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIAH1 |
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