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SIAH1 Gene

protein-coding   GIFtS: 65

GC16M046951
seven in absentia homolog 1 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for SIAH1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 6.3.2.- 3
FLJ08065 2
HUMSIAH 2, 3
Siah-1 2, 3
Siah-1a 2, 3
hSIAH1 1, 2
Descriptions
Seven in absentia homolog 1 2, 3
seven in absentia homolog 1 (Drosophila) 2
sonic hedgehog homolog 2
External Ids
HGNC: 108571
Entrez Gene: 64772
UniProtKB: Q8IUQ43
Ensembl: ENSG000001964707
Search outside databases for aliases for SIAH1 gene

Previous GC identifers: GC16M038809 GC16M048443 GC16M048131 GC16M048172

Summaries
for SIAH1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for SIAH1:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The
protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of
specific proteins. The activity of this ubiquitin ligase has been implicated in the development of
certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and
induction of apoptosis. Alternative splicing results in several additional transcript variants,
some encoding different isoforms and others that have not been fully characterized. [provided by
RefSeq]

UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal
degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2
ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin
to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to
substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers
the ubiquitin-mediated degradation of many substrates, including proteins involved in
transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic
signal transduction molecules (TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule
motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a
structural protein (CTNNB1) and SNCAIP. It is thereby involved in many cellular processes such as
apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis
and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in
cooperation with PEG3 (By similarity)

Gene Wiki entry for SIAH1

Genomic Location
for SIAH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SIAH1 gene  

Entrez Gene cytogenetic band: 16q12   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12

SIAH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M046951:     (about GC identifiers)

Start:
 46,951,943 bp from pter
End:
 46,976,730 bp from pter
Size:
 24,788 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010498.15  

Proteins
for SIAH1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase SIAH1  
Size: 282 amino acids; 31123 Da
Subunit: Homodimer. Interacts with group 1 glutamate receptors GRM1 and GRM5. Interacts with DAB1,
which may inhibit its activity. Interacts with UBE2E2. Interacts with PEG3 (By similarity).
Component of some large E3 complex composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.
Interacts with UBE2I. Interacts with alpha-tubulin. Interacts with PEG10, which may inhibit its
activity. Interacts with KHDRBS3
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear
PDB structures from and Proteopedia :
2A25 (3D)    
Secondary accessions: A0FKF3 O43269 Q49A58 Q92880
Alternative splicing: 3 isoforms:  Q8IUQ4-1   Q8IUQ4-2   Q8IUQ4-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001006611.1  NP_003022.3  


    ENSEMBL proteins: 
    ENSP00000349156 ENSP00000353090 ENSP00000378214 ENSP00000369343 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SIAH1/2, SIAH1)
    Human Recombinant Proteins from Abnova (SIAH1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm TAS9334332
    About this table

    Antibodies for SIAH1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SIAH1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SIAH1/2, SIAH1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SIAH1)
    Novus Biologicals Antibodies for SIAH1

    Assays for SIAH1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SIAH1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro domains/families (see all 7 ):
     IPR017907 Znf_RING_CS
     IPR018121 7-in-absentia-prot_TRAF-dom
     IPR001841 Znf_RING
     IPR013010 Znf_SIAH
     IPR013323 SIAH-type


       GeneDecks  SIAH1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8IUQ4

    ProtoNet protein and cluster: Q8IUQ4

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4
    Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activity
    Domain: The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction
    with substrate proteins. It is related to the TRAF family (By similarity)
    Similarity: Belongs to the SINA (Seven in absentia) family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SIAH-type zinc finger

    Gene Function
    for SIAH1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SIAH1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SIAH1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003031

                  Applied Biosystems Silencer® siRNAs for SIAH1

                  Sigma-Aldrich siRNA and siRNA Panels for SIAH1  
                         Sigma-Aldrich shRNA Panels and shRNA for SIAH1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SIAH1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006610
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006610
                                     untagged cDNA clones in CMV expression vector (see all 4): AK094663 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001006610

    UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4
    Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal
    degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2
    ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin
    to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to
    substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers
    the ubiquitin-mediated degradation of many substrates, including proteins involved in
    transcription regulation (MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic
    signal transduction molecules (TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule
    motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a
    structural protein (CTNNB1) and SNCAIP. It is thereby involved in many cellular processes such as
    apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis
    and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in
    cooperation with PEG3 (By similarity)
    Induction: May be induced by TP53/p53, suggesting that it may be required to modulate TP53
    response. The relevance of such activity in vivo is however unclear and may not exist
    Enzyme Number (IUBMB): EC 6.3.2.- 

    Genatlas biochemistry entry for SIAH1:
    Drosophila seven in absentia (sina) homolog 1,putatively involved in apoptosis and tumor
    suppression,also mediating through RING finger ubiquitin-conjugating enzyme (E2)-dependent
    ubiquitination

    7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Siah1a):

    cellularendocrine/exocrine glandgrowth/sizelethality-prenatal/perinatallife span-post-weaning/aging
    liver/biliary systemreproductive system

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842 ubiquitin-protein ligase activity IEA--
    GO:0008022 protein C-terminus binding IPI11389840
    GO:0008270 zinc ion binding IDA11863358
    GO:0016874 ligase activity IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for SIAH1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for SIAH1
     Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

       GeneDecks  SIAH1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SIAH1  (Your Favorite Gene powered by Ingenuity) 
     Tryptophan Metabolism

       GeneDecks  SIAH1 for the pathways selected above  
    About GeneDecksing

    3 Kegg Pathways  (Kegg details for SIAH1):
     hsa04115 p53 signaling pathway
     hsa04120 Ubiquitin mediated proteolysis
     hsa04310 Wnt signaling pathway

       GeneDecks  SIAH1 for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4
    Pathway: Protein modification; protein ubiquitination

     Gene Network CentralTM Interacting Genes and Proteins Network for  SIAH1 


    5/43 Interacting proteins for SIAH1 (ENSP000003530903 Q8IUQ41, 2) via UniProtKB, MINT, and/or STRING (see all 43 )

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACYBPQ9HB712STRING (score=.99) MINT-18767 MINT-18768
    KHDRBS3O755252STRING (score=.963) MINT-68424
    Sh3rf1 Sh3rf1 (xeno)Q69ZI11EBI-747107, EBI-957380
    SLC9A3R2Q155992MINT-14500 MINT-14499
    AFF4Q9UHB72MINT-66990
    About this table

    5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis TAS9334332
    GO:0006511 ubiquitin-dependent protein catabolic process IEA--
    GO:0006915 apoptosis TAS9403064
    GO:0007049 cell cycle IEA--
    GO:0007275 multicellular organismal development IEA--
    About this table

    Drugs & Compounds
    for SIAH1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SIAH1
    1 Novoseek chemical compound relationship for SIAH1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 0.00 6 16752048 (1), 15951807 (1)
    About this table


    Transcripts
    for SIAH1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SIAH1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SIAH1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003031

                  Sigma-Aldrich siRNA and siRNA Panels for SIAH1  
                         Sigma-Aldrich shRNA Panels and shRNA for SIAH1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001006610  NM_003031  

    REFSEQ mRNAs for SIAH1 gene (2 alternative transcripts): 

    NM_001006610.1   NM_003031.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001006610  NM_003031  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006610
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006610
                                     untagged cDNA clones in CMV expression vector (see all 4): AK094663 

    Additional cDNA sequence: 

    AB451253.1 AB451377.1 AK023458.1 AK094663.1 AK225895.1 AK313861.1 BC018193.1 BC035562.1 
    BC042550.1 BC044920.1 BX647064.1 CR593197.1 CR598465.1 CR607323.1 CR614925.1 EF026094.1 
    U63295.1 U76247.1 

    21 DOTS entries:

    DT.85105309  DT.91937961  DT.91747164  DT.95181842  DT.95181829  DT.100765820  DT.100026014  DT.91759232 
    DT.97833637  DT.100790999  DT.91920720  DT.95181828  DT.100791002  DT.120721569  DT.40203481  DT.75136444 
    DT.85105366  DT.100685789  DT.120721489  DT.95181831  DT.99955674 

    24/228 AceView cDNA sequences (see all 228 ):

    AI248783 CR598465 AI810587 AI305834 CR593197 AK094663 AA885525 AA447531 
    CD679103 AA948066 AW768860 AU136155 AV661355 BQ181813 BE676461 AI972089 
    BU521256 BQ027303 AW167318 AV661329 T11012 AI560284 AA934422 BM699360 

    highest scoring ESTs for SIAH1:

    U76247 AU099135 AU136155 AU136857 AV654246 BC018193 BC035562 BF033914 BG489183 BG899050 

    Unigene Cluster for SIAH1:

    Seven in absentia homolog 1 (Drosophila)
    Hs.295923  [show with all ESTs]
    Unigene Representative Sequence: BX647064


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations:
    ENST00000356721  ENST00000359996  ENST00000394725  ENST00000380006  

    Expression
    for SIAH1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SIAH1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SIAH1

    1 / 2 / 3

    8 probe-sets matching SIAH1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    87291_at2, 3 U95-D 1 1.00 1.00 0.96 0.97 AA699591 0.60 1.00 0.82 1
    32160_at2, 3 U95-A 1 1.00 1.00 0.51 1.04 U76247 1.00 1.00 1.00 1

    		202981_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003031 0.60 1.00 0.82 1

    		202980_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI953523 0.60 1.00 0.82 1

    		232365_at2, 3 U133-B 1 1.00 1.00 -- -- BE676461 0.40 1.00 0.76 1

    		202981_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		202980_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		232365_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SIAH1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CACAGTATTT

    SOURCE GeneReport for Unigene cluster: Hs.295923

    Expression variation in blood from EXPOLDB for SIAH1

    UniProtKB/Swiss-Prot: SIAH1_HUMAN, Q8IUQ4
    Tissue specificity: Widely expressed at low level. Down-regulated in advanced hepatocellular
    carcinomas

    Orthologs
    for SIAH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SIAH1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SIAH11   -- seven in absentia homolog 1 (Drosophila) 93.72(n)
    97.44(a)    		 487293  XM_544419.2  XP_544419.1 
    chimpanzee
    (Pan troglodytes)    		 SIAH11   -- seven in absentia homolog 1 (Drosophila) 99.65(n)
    100(a)    		 465153  XM_520625.2  XP_520625.1 
    cow
    (Bos taurus)    		 SIAH11   -- seven in absentia homolog 1 (Drosophila) 93.61(n)
    97.44(a)    		 534655  XM_870881.2  XP_875974.2 
    rat
    (Rattus norvegicus)    		 Siah1a1   -- seven in absentia 1A 91.84(n)
    99.65(a)    		 140941  NM_080905.2  NP_543181.2 
    mouse
    (Mus musculus)    		 Siah1a1, 5 8 (38.50 cM)5
    		 seven in absentia 1A1, 5 92.67(n)1
    99.65(a)1    		 204371  NM_009172.11  NP_033198.11 
     AA9820645  AI8535005  (see all 12)
    About this table        Species with no ortholog for SIAH1

    ENSEMBL Gene Tree for SIAH1

    Paralogs
    for SIAH1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SIAH1 gene
    SIAH32  SIAH22  

    SNPs/Variants
    for SIAH1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/104 NCBI SNPs in SIAH1 are shown (see all 104 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 34)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs81901,2
    		A,C,F,H,O46952127(-) TTTCAG/AATATC 2 -- ut316Minor allele frequency- A:0.14MN EU EA WA 790
    rs80543141,2
    		A,C,F,H46951831(+) CTACCG/ACACTT 2 -- ng517Minor allele frequency- A:0.16EU EA WA NA 550
    rs10601551,2
    		H46953051(-) GCATTG/TCACAG 2 A/S mis1 ese35Minor allele frequency- T:0.00MN EU EA WA 590
    rs129288801,2
    		F46957355(+) CTGCGT/CTGGGA 2 -- int1 ng314Minor allele frequency- C:0.13NA EA 362
    rs47855161,2
    		C46957418(+) GGGCGA/GTGCCC 2 -- ng31 int10--------
    rs38096851,2
    		H46978094(-) CTTCCC/TGTGTA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 414
    rs344376401,2
    		F46953691(+) ATGGGC/TGGTAA 2 P/P syn11Minor allele frequency- T:0.03NA 74
    rs47855181,2
    		A,C,H46975775(+) TTTCCA/GGGAAC 1 -- int14Minor allele frequency- G:0.00EU EA WA 418
    --
    rs71867771,2
    		A,C46962609(+) gatcaC/Ggtgag 1 -- int10--------
    --
    rs118607891,2
    		A,C46966782(+) gcagtA/Ggctca 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for SIAH1 (up to first 250kb)

    Disorders & Mutations
    for SIAH1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 602212

    1 Novoseek disease relationship for SIAH1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 47.89 2 16752048 (2)
    About this table

    Human Genome Epidemiology Navigator: SIAH1 (1 document)

    Medical News
    for SIAH1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SIAH1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/69 PubMed articles for SIAH1 gene (see all 69 ):

    Search for SIAH1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SIAH1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6477 HGNC: 10857 AceView: SIAH1 Ensembl:ENSG00000196470 euGenes: HUgn6477
    ECgene: SIAH1 H-InvDB: SIAH1

    Other Databases showing SIAH1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SIAH1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for SIAH1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for SIAH1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SIAH1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SIAH1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SIAH1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SIAH1 Antibodies for SIAH1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SIAH1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (SIAH1)
     Antibodies (SIAH1)
     Chimera RNAi (SIAH1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (SIAH1/2, SIAH1)
     Antibodies (SIAH1/2, SIAH1)
     Search OriGene for SIAH1
     Search Tocris compounds for SIAH1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SIAH1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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