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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIAE Gene

protein-coding   GIFtS: 46
GCID: GC11M124505

sialic acid acetylesterase

(Previous name: Ysg2 homolog (mouse) )
(Previous symbol: YSG2)
 Explore 13 diseases affiliated with
SIAE via our new
 Human Malady Compendium 
Biological research products
for SIAE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sialic Acid Acetylesterase1 2     MGC870091
YSG21 2 3     Ysg2 Homolog (Mouse)1
CSE-C1 2     CSEC2
LSE1 2     Cytosolic Sialic Acid 9-O-Acetylesterase Homolog2
H-Lse2 3     Sialate O-Acetylesterase2
EC 3.1.1.533 8     Sialic Acid-Specific Acetylesterase II2
AIS62 5     Sialic Acid-Specific 9-O-Acetylesterase3

External Ids:    HGNC: 181871   Entrez Gene: 544142   Ensembl: ENSG000001100137   OMIM: 6100795   UniProtKB: Q9HAT23   

Export aliases for SIAE gene to outside databases

Previous GC identifers: GC11M124011 GC11M120448


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIAE:
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are
associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms,
found either in the cytosol or in the lysosome, have been found for this gene.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: SIAE_HUMAN, Q9HAT2
Function: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic
acid




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIAE gene promoter:
         TBP   PPAR-gamma1   NF-1   AML1a   COMP1   Lmo2   PPAR-gamma2   IRF-1   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIAE promoter sequence
   Search SABiosciences Chromatin IP Primers for SIAE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIAE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

SIAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIAE gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M124505:  view genomic region     (about GC identifiers)

Start:
124,503,009 bp from pter      End:
124,565,603 bp from pter
Size:
62,595 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIAE_HUMAN, Q9HAT2 (See protein sequence)
Recommended Name: Sialate O-acetylesterase precursor  
Size: 523 amino acids; 58315 Da
Subcellular location: Lysosome (Probable). Secreted
Secondary accessions: B3KPB0 Q8IUT9 Q9HAU7 Q9NT71
Alternative splicing: 2 isoforms:  Q9HAT2-1   Q9HAT2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIAE: NX_Q9HAT2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HAT2

  • 3 DME Specific Peptides for SIAE (Q9HAT2)
     LQYPIGL  HSVLWNAMI  LKGVVWYQGE 

    SIAE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186851.1  NP_733746.1  

    ENSEMBL proteins: 
     ENSP00000263593   ENSP00000437877  

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    Novus Biologicals SIAE Protein
    Novus Biologicals SIAE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SIAE

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--


    SIAE for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SIAE


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SIAE for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005181 DUF303_acetylest

    Graphical View of Domain Structure for InterPro Entry Q9HAT2

    ProtoNet protein and cluster: Q9HAT2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SIAE_HUMAN, Q9HAT2
    Function: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic
    acid
    Catalytic activity: N-acetyl-O-acetylneuraminate + H(2)O = N-acetylneuraminate + acetate

    Enzyme Number (IUBMB): EC 3.1.1.531 2

    miRNA
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    hsa-miR-1276 hsa-miR-3688-3p hsa-miR-1252 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidSIAE 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: SIAE
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAE

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001681sialate O-acetylesterase activity IEA--
    GO:0004091carboxylesterase activity IEA--


    SIAE for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Siaetm1.2Avrk for SIAE
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Siae):
     cellular  hematopoietic system  immune system  no phenotypic analysis  renal/urinary system 

    SIAE for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIAE

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIAE

    3 HMDB Compounds for SIAE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    N-Acetylneuraminic acidSialic acid (see all 55)131-48-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about SIAE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIAE gene (3 alternative transcripts): 
    NM_001199922.1  NM_170601.4  NM_018978.1  

    Unigene Cluster for SIAE:

    Sialic acid acetylesterase
    Hs.10056  [show with all ESTs]
    Unigene Representative Sequence: NM_001199922
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263593(uc001qan.3 uc021qru.1) ENST00000533613 ENST00000436137(uc001qao.2)
    ENST00000525730 ENST00000545756

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SIAE:
    hsa-miR-1276 hsa-miR-3688-3p hsa-miR-1252 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidSIAE 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: SIAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIAE
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIAE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIAE

    Additional cDNA sequence: 

    AF300796.1 AF303378.1 AK056093.1 AK092224.1 AL137496.1 BC022456.1 BC068450.1 

    5 DOTS entries:

    DT.95265897  DT.95260668  DT.95363553  DT.97765290  DT.40122733 

    24/161 AceView cDNA sequences (see all 161):

    AA480369 AA934509 T36167 AK092224 AA284488 AA846421 BC068450 AI278795 
    AI719065 AI278287 AA805065 AF303378 AK056093 AI056195 AA782685 BQ019261 
    T49454 AA213991 NM_170601 AA910676 AA772356 AA639769 AA694474 BX507522 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIAE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAGCATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SIAE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIAE

    SOURCE GeneReport for Unigene cluster: Hs.10056

    UniProtKB/Swiss-Prot: SIAE_HUMAN, Q9HAT2
    Tissue specificity: Widely expressed with high expression in the testis, prostate, and colon

        SABiosciences Custom PCR Arrays for SIAE
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIAE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SIAE gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siae1 , 5 sialic acid acetylesterase1, 5 82.43(n)1
    80.16(a)1
      9 (20.79 cM)5
    226191  NM_011734.31  NP_035864.21 
     376138475 
    lizard
    (Anolis carolinensis)
    Reptilia SIAE6
    --
    55(a)
    1 ↔ 1
    GL343322.1(162558-174323)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686882 hypothetical protein MGC68688 73.05(n)    BC059983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564542 similar to yolk sac gene 2 76.4(n)   393259  BC049448.1 


    ENSEMBL Gene Tree for SIAE (if available)
    TreeFam Gene Tree for SIAE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 NCBI SNPs in SIAE are shown (see all 619    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787786221,2
    C,F,other124757016(+) CTTCAT/CAGGAT 4 /M /V mis15Minor allele frequency- C:0.04NA EA EU 6113
    rs1430705991,2
    C,F,other124767984(+) GCCAGC/AACACT 4 /C /F mis11Minor allele frequency- A:0.00NA 4552
    rs1445108781,2
    C,F,other124770342(+) GCTCCG/ATCTGC 4 /T /M mis11Minor allele frequency- A:0.00NA 4552
    rs2018771491,2
    C,Fother124779088(+) CTTCAA/GAGGTC 4 S F mis11Minor allele frequency- G:0.00EU 1323
    rs1134195761,2
    --120447780(+) CCAGAG/ACCCCT 2 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs736224931,2
    C,--120448041(+) CTTTAG/TTTCTC 2 -- ds50012Minor allele frequency- T:0.09WA 120
    rs743850641,2
    C,F,--120448138(+) ATAAAT/CACATA 2 -- ds50011Minor allele frequency- C:0.03EA 120
    rs755998251,2
    --120448152(+) ATCACC/TAGTGA 2 -- ut310--------
    rs118227131,2
    C,F,H,--120448414(+) AACTCG/AAACAA 2 -- ut313Minor allele frequency- A:0.05WA NA 124
    rs129951,2
    C,F,H--120448430(+) TGCCTC/ATGTTG 2 -- ut31 ese36Minor allele frequency- A:0.01MN NS NA 796

    HapMap Linkage Disequilibrium report for SIAE (124503009 - 124565603 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SIAE
         2 CNVs: 86063 75833
    Human Gene Mutation Database (HGMD): SIAE

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIAE
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SIAE for disorders           About GeneDecksing

    OMIM gene information: 610079   
    OMIM disorders: 613551  
    UniProtKB/Swiss-Prot: SIAE_HUMAN, Q9HAT2
  • Defects in SIAE are a cause of autoimmune disease type 6 (AIS6) [MIM:613551]. Individuals manifesting
  • susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis,
    multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn
    disease

    13 diseases for SIAE:    About MalaCards
    autoimmune disease 6    type 1 diabetes mellitus    systemic lupus erythematosus    lupus erythematosus
    diabetes mellitus    ulcerative colitis    sjogren's syndrome    graves' disease
    rheumatoid arthritis    crohn's disease    arthritis    influenza
    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: SIAE (4 documents)

    Export disorders for SIAE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIAE gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SIAE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functionally defective germline variants of sialic ac id acetylesterase in autoimmunity. (PubMed id 20555325)1, 2 Surolia I....Pillai S. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A gene encoding sialic-acid-specific 9-O-acetylesterase found in human adult testis. (PubMed id 15292578)1, 2 Zhu H....Sha J.H. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus. (PubMed id 10464298)1, 3 Takematsu H....Varki A. (1999)
    6. Regulation of O-acetylation of sialic acids by sialate -O-acetyltransferase and sialate-O-acetylesterase activities in childhood acute lymphoblastic leukemia. (PubMed id 21803834)1 Mandal C....Mandal C. (2012)
    7. Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes. (PubMed id 22257840)1 Hirschfield G.M....Siminovitch K.A. (2012)
    8. The role of functionally defective rare germline varia nts of sialic acid acetylesterase in autoimmune Addison's disease. (PubMed id 23011869)1 Gan E.H....Pearce S.H. (2012)
    9. Transcriptional profiling of human placentas from preg nancies complicated by preeclampsia reveals disregulation of sialic acid acetyle sterase and immune signalling pathways. (PubMed id 21183218)1 Tsai S....Piedrahita J.A. (2011)
    10. Functionally defective germline variant of sialic aci d acetylesterase (Met89Val) is not associated with type 1 diabetes mellitus and Graves' disease in a Polish population. (PubMed id 21615338)1 SzymaA8ski K....PA8oski R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54414 HGNC: 18187 AceView: CSE-C Ensembl:ENSG00000110013 euGenes: HUgn54414
    ECgene: SIAE H-InvDB: SIAE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIAE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIAE gene:
    Search GeneIP for patents involving SIAE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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