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Aliases for SIAE Gene

Aliases for SIAE Gene

  • Sialic Acid Acetylesterase 2 3
  • Sialic Acid-Specific Acetylesterase II 2 3
  • EC 4 63
  • H-Lse 3 4
  • YSG2 3 4
  • AIS6 3 6
  • Cytosolic Sialic Acid 9-O-Acetylesterase Homolog 3
  • Sialic Acid-Specific 9-O-Acetylesterase 4
  • Sialate O-Acetylesterase 3
  • Ysg2 Homolog (Mouse) 2
  • CSE-C 3
  • CSEC 3
  • LSE 3

External Ids for SIAE Gene

Previous HGNC Symbols for SIAE Gene

  • YSG2

Previous GeneCards Identifiers for SIAE Gene

  • GC11M124011
  • GC11M124505
  • GC11M120448

Summaries for SIAE Gene

Entrez Gene Summary for SIAE Gene

  • This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for SIAE Gene

SIAE (Sialic Acid Acetylesterase) is a Protein Coding gene. Diseases associated with SIAE include autoimmune disease 6. GO annotations related to this gene include sialate O-acetylesterase activity.

UniProtKB/Swiss-Prot for SIAE Gene

  • Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIAE Gene

Genomics for SIAE Gene

Regulatory Elements for SIAE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SIAE Gene

124,633,113 bp from pter
124,695,707 bp from pter
62,595 bases
Minus strand

Genomic View for SIAE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIAE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIAE Gene

Proteins for SIAE Gene

  • Protein details for SIAE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sialate O-acetylesterase
    Protein Accession:
    Secondary Accessions:
    • B3KPB0
    • Q8IUT9
    • Q9HAU7
    • Q9NT71

    Protein attributes for SIAE Gene

    523 amino acids
    Molecular mass:
    58315 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIAE Gene


neXtProt entry for SIAE Gene

Proteomics data for SIAE Gene at MOPED

Selected DME Specific Peptides for SIAE Gene

Post-translational modifications for SIAE Gene

  • Glycosylation at Asn107, Asn138, Asn267, Asn290, Asn401, and Asn422
  • Modification sites at PhosphoSitePlus

Other Protein References for SIAE Gene

Domains for SIAE Gene

Protein Domains for SIAE Gene


Suggested Antigen Peptide Sequences for SIAE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIAE: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SIAE Gene

Function for SIAE Gene

Molecular function for SIAE Gene

UniProtKB/Swiss-Prot CatalyticActivity: N-acetyl-O-acetylneuraminate + H(2)O = N-acetylneuraminate + acetate
UniProtKB/Swiss-Prot Function: Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid

Enzyme Numbers (IUBMB) for SIAE Gene

Gene Ontology (GO) - Molecular Function for SIAE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001681 sialate O-acetylesterase activity IDA 23308225
genes like me logo Genes that share ontologies with SIAE: view
genes like me logo Genes that share phenotypes with SIAE: view

Animal Models for SIAE Gene

MGI Knock Outs for SIAE:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for SIAE Gene

Localization for SIAE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIAE Gene

Lysosome. Secreted.

Subcellular locations from

Jensen Localization Image for SIAE Gene COMPARTMENTS Subcellular localization image for SIAE gene
Compartment Confidence
extracellular 5
lysosome 4
vacuole 4
cytosol 2
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SIAE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SIAE: view

Pathways for SIAE Gene

SuperPathways for SIAE Gene

No Data Available

Interacting Proteins for SIAE Gene

Gene Ontology (GO) - Biological Process for SIAE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process IMP 20555325
GO:0005975 carbohydrate metabolic process IDA 23308225
genes like me logo Genes that share ontologies with SIAE: view

No data available for Pathways by source for SIAE Gene

Compounds for SIAE Gene

(3) HMDB Compounds for SIAE Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
N-Acetylneuraminic acid
  • Sialic acid
  • Dihydrogen oxide
genes like me logo Genes that share compounds with SIAE: view

Transcripts for SIAE Gene

Unigene Clusters for SIAE Gene

Sialic acid acetylesterase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIAE

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SIAE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIAE Gene

No ASD Table

Relevant External Links for SIAE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIAE Gene

mRNA expression in normal human tissues for SIAE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SIAE Gene

SOURCE GeneReport for Unigene cluster for SIAE Gene Hs.10056

mRNA Expression by UniProt/SwissProt for SIAE Gene

Tissue specificity: Widely expressed with high expression in the testis, prostate, and colon.
genes like me logo Genes that share expressions with SIAE: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SIAE Gene

Orthologs for SIAE Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIAE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIAE 35
  • 99.17 (n)
  • 99.04 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SIAE 35
  • 81.1 (n)
  • 77.78 (a)
  • 76 (a)
(Canis familiaris)
Mammalia SIAE 35
  • 84.68 (n)
  • 81.73 (a)
  • 68 (a)
(Mus musculus)
Mammalia Siae 35
  • 82.73 (n)
  • 80.8 (a)
Siae 16
Siae 36
  • 76 (a)
(Monodelphis domestica)
Mammalia SIAE 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia SIAE 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Siae 35
  • 82.4 (n)
  • 81.2 (a)
(Anolis carolinensis)
Reptilia SIAE 36
  • 52 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68688 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493404 35
  • 57.42 (n)
  • 55.07 (a)
Str.14836 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10577 35
(Danio rerio)
Actinopterygii siae 35
  • 56.94 (n)
  • 51.76 (a)
siae 36
  • 50 (a)
zgc56454 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
-- 36
  • 32 (a)
-- 36
  • 48 (a)
-- 36
  • 37 (a)
-- 36
  • 41 (a)
-- 36
  • 40 (a)
Species with no ortholog for SIAE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIAE Gene

Gene Tree for SIAE (if available)
Gene Tree for SIAE (if available)

Paralogs for SIAE Gene

No data available for Paralogs for SIAE Gene

Variants for SIAE Gene

Sequence variations from dbSNP and Humsavar for SIAE Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs493319 -- 124,645,292(-) CTGAT(C/T)CTTGT intron-variant
rs512225 -- 124,669,340(-) CTTCC(A/G)TTCAG intron-variant
rs544368 -- 124,668,099(-) GGGAG(A/G)CTTGT intron-variant
rs620499 -- 124,639,629(+) TCTAA(C/T)TGCCC intron-variant
rs1942662 -- 124,662,604(-) CTTTT(A/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIAE Gene

Variant ID Type Subtype PubMed ID
esv2678188 CNV Deletion 23128226

Relevant External Links for SIAE Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIAE Gene

Disorders for SIAE Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SIAE Gene including...

Search for SIAE Gene in MalaCards »

(1) OMIM Diseases for SIAE Gene (610079)


  • Autoimmune disease 6 (AIS6) [MIM:613551]: Individuals manifesting susceptibility to autoimmune disease type 6 can suffer from juvenile idiopathic arthritis, rheumatoid arthritis, multiple sclerosis, Sjogren syndrome, systemic lupus erythematosus, type 1 diabetes, ulcerative colitis, and Crohn disease. {ECO:0000269 PubMed:20555325}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for SIAE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SIAE: view

Publications for SIAE Gene

  1. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. (PMID: 20555325) Surolia I. … Pillai S. (Nature 2010) 3 4 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A gene encoding sialic-acid-specific 9-O-acetylesterase found in human adult testis. (PMID: 15292578) Zhu H. … Sha J.H. (J. Biomed. Biotechnol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SIAE Gene

Sources for SIAE Gene

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