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SHROOM4 Gene

protein-coding   GIFtS: 47
GCID: GC0XM050351

Shroom Family Member 4

  See SHROOM4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shroom Family Member 41 2
Second Homolog Of Apical Protein2 3
SHAP2 3
KIAA12023 5
Protein Shroom42
SDSX5

External Ids:    HGNC: 292151   Entrez Gene: 574772   Ensembl: ENSG000001583527   OMIM: 3005795   UniProtKB: Q9ULL83   

Export aliases for SHROOM4 gene to outside databases

Previous GC identifer: GC0XM047778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHROOM4 Gene:
This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2
motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked
to Stocco dos Santos X-linked mental retardation syndrome. Alternatively spliced transcript variants have been
described. (provided by RefSeq, Mar 2009)

GeneCards Summary for SHROOM4 Gene:
SHROOM4 (shroom family member 4) is a protein-coding gene. Diseases associated with SHROOM4 include stocco dos santos syndrome. GO annotations related to this gene include actin filament binding. An important paralog of this gene is SHROOM1.

UniProtKB/Swiss-Prot: SHRM4_HUMAN, Q9ULL8
Function: Probable regulator of cytoskeletal architecture that plays an important role in development. May
regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHROOM4 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx2-2   RelA   Nkx3-1 v1   Nkx2-5   NF-kappaB   Nkx3-1 v2   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHROOM4 promoter sequence
   Search Chromatin IP Primers for SHROOM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHROOM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

SHROOM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHROOM4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM050351:  view genomic region     (about GC identifiers)

Start:
50,334,642 bp from pter      End:
50,557,302 bp from pter
Size:
222,661 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHRM4_HUMAN, Q9ULL8 (See protein sequence)
Recommended Name: Protein Shroom4  
Size: 1493 amino acids; 164857 Da
Subunit: Interacts directly with F-actin (By similarity)
Sequence caution: Sequence=BAA86516.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAM13070.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for SHROOM4:
2EDP (3D)    
Secondary accessions: A7E2X9 D6RFW0 Q96LA0
Alternative splicing: 2 isoforms:  Q9ULL8-1   Q9ULL8-2   

Explore the universe of human proteins at neXtProt for SHROOM4: NX_Q9ULL8

Explore proteomics data for SHROOM4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHROOM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065768.2  
    ENSEMBL proteins: 
     ENSP00000289292   ENSP00000421450   ENSP00000365188  

    SHROOM4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SHROOM4

     
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    SHROOM4 Assay Products:

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    Search eBioscience for ELISAs for SHROOM4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027687 Shroom4
     IPR027685 Shroom_fam
     IPR001478 PDZ
     IPR014799 ASD2

    Graphical View of Domain Structure for InterPro Entry Q9ULL8

    ProtoNet protein and cluster: Q9ULL8

    UniProtKB/Swiss-Prot: SHRM4_HUMAN, Q9ULL8
    Similarity: Belongs to the shroom family
    Similarity: Contains 1 ASD2 domain
    Similarity: Contains 1 PDZ (DHR) domain


    Find genes that share domains with SHROOM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHRM4_HUMAN, Q9ULL8
    Function: Probable regulator of cytoskeletal architecture that plays an important role in development. May
    regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051015actin filament binding ISS--
         
    Find genes that share ontologies with SHROOM4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHROOM4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHROOM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHROOM4

    miRNA
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    miRTarBase miRNAs that target SHROOM4:
    hsa-mir-335-5p (MIRT018002)

    Block miRNA regulation of human, mouse, rat SHROOM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHROOM4 (see all 57):
    hsa-miR-4291 hsa-miR-100* hsa-miR-642a hsa-miR-1197 hsa-miR-15a hsa-miR-218-1* hsa-miR-29a hsa-miR-765
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHROOM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHRM4_HUMAN, Q9ULL8: Cytoplasm, cytoskeleton. Note=Shows partial colocalization with the cytoplasmic pool of
    F-actin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    nucleus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725colocalizes with stress fiber ISS--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ISS--
    GO:0009898cytoplasmic side of plasma membrane IDA16249884
    GO:0009925basal plasma membrane ISS--

    Find genes that share ontologies with SHROOM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHROOM4
    Interactions:

        Search GeneGlobe Interaction Network for SHROOM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SHROOM4 (ENSP000002892924) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYBPC3ENSP000003821934STRING: ENSP00000382193
    MYH1ENSP000002262074STRING: ENSP00000226207
    MYH10ENSP000002692434STRING: ENSP00000269243
    MYH11ENSP000003796164STRING: ENSP00000379616
    MYH13ENSP000002521724STRING: ENSP00000252172
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902NOT cell morphogenesis IDA16684770
    GO:0007015actin filament organization ISS--
    GO:0007420brain development IDA16249884
    GO:0030036actin cytoskeleton organization NAS16684770
    GO:0050890cognition IDA16249884

    Find genes that share ontologies with SHROOM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHROOM4 (SHRM4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHROOM4 gene: 
    NM_020717.3  

    Unigene Cluster for SHROOM4:

    Shroom family member 4
    Hs.420541  [show with all ESTs]
    Unigene Representative Sequence: NM_020717
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289292(uc004dpd.3) ENST00000483955 ENST00000460112(uc004dpf.1)
    ENST00000484922 ENST00000376020(uc004dpe.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat SHROOM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHROOM4 (see all 57):
    hsa-miR-4291 hsa-miR-100* hsa-miR-642a hsa-miR-1197 hsa-miR-15a hsa-miR-218-1* hsa-miR-29a hsa-miR-765
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: SHROOM4 (NM_020717)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHROOM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHROOM4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHROOM4
      QuantiTect SYBR Green Assays in human, mouse, rat SHROOM4
      QuantiFast Probe-based Assays in human, mouse, rat SHROOM4

    Additional mRNA sequence: 

    AB033028.1 AK092659.1 AK127486.1 AY044234.1 BC151240.1 NR_027121.1 

    4 DOTS entries:

    DT.102766  DT.95285309  DT.100013026  DT.430767 

    Selected AceView cDNA sequences (see all 34):

    AW001038 AY044234 CK902532 H67589 AW473467 AL707209 AK127486 AA515902 
    BU194023 AB033028 BX472125 CK902533 BU078027 AV729515 BQ016983 AW972020 
    BU682945 AI005420 AK092659 BU078275 BF813324 BE890569 AA147516 BF107195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHROOM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SHROOM4 Expression
    About this image


    SHROOM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    SHROOM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHROOM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420541

    UniProtKB/Swiss-Prot: SHRM4_HUMAN, Q9ULL8
    Tissue specificity: Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain,
    placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral
    cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is
    strongest in the medulla and weakest in the cerebral cortex

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHROOM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHROOM4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shroom41 , 5 shroom family member 41, 5 82.65(n)1
    78.49(a)1
      X (2.85 cM)5
    2084311  NM_001040459.11  NP_001035549.11 
     63998545 
    chicken
    (Gallus gallus)
    Aves LOC7770721 protein Shroom2-like 59.17(n)
    53.35(a)
      777072  XM_003641133.2  XP_003641181.2 
    lizard
    (Anolis carolinensis)
    Reptilia SHROOM46
    shroom family member 4
    43(a)
    1 ↔ 1
    GL343577.1(6460-48912)
    zebrafish
    (Danio rerio)
    Actinopterygii shroom46
    shroom family member 4
    25(a)
    1 ↔ 1
    7(25896649-25980111) ENSDARG00000079900
    fruit fly
    (Drosophila melanogaster)
    Insecta Shroom6
    Shroom
    15(a)
    1 → many
    2R(10195667-10239312)


    ENSEMBL Gene Tree for SHROOM4 (if available)
    TreeFam Gene Tree for SHROOM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHROOM4 gene
    SHROOM12  SHROOM32  SHROOM22  
    1 SIMAP similar gene for SHROOM4 using alignment to 1 protein entry:     SHRM4_HUMAN:
    DKFZp781J074

    Find genes that share paralogs with SHROOM4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHROOM4 (see all 2804)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0322584
    Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX)4--see VAR_0322582 S L mis40--------
    rs32156521,2
    C--50336529(-) GGGGGG/-TGGGG 4 -- int1 ut311Minor allele frequency- -:0.00CSA 2
    rs1892561231,2
    --50346201(+) ATTTCC/TCTTGG 2 -- ds50010--------
    rs1389893031,2
    C--50346308(+) CCACAC/TTGTCT 2 -- ds50010--------
    rs66145461,2
    C,F,A,H--50346449(+) cttacG/Acaagg 2 -- ds500118Minor allele frequency- A:0.32NS EA WA NA 1985
    rs23162021,2
    C,H--50346479(-) atccaA/Gtgctt 2 -- ds50019Minor allele frequency- G:0.00WA NA CSA 16
    rs1847691361,2
    --50346627(+) AGTTTC/TGCACT 2 -- ds50010--------
    rs761046271,2
    C--50346700(+) TTCTTG/TCTTTC 2 -- nc-transcript-variantut310--------
    rs771714871,2
    C--50346718(+) CTTTCG/TTTTCT 2 -- nc-transcript-variantut310--------
    rs2016223701,2
    C--50346719(+) TTTCT-/TTT   
       CTTTC
    TTTCT
    2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for SHROOM4 (50334642 - 50557302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SHROOM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740160CNV Deletion23290073
    esv2351992CNV Deletion18987734
    esv2740159CNV Deletion23290073
    esv1223545CNV Deletion17803354
    esv2740158CNV Deletion23290073
    nsv508772CNV Insertion20534489
    nsv527767CNV Gain19592680

    Human Gene Mutation Database (HGMD): SHROOM4
    Locus Specific Mutation Databases (LSDB): SHROOM4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHROOM4
    DNA2.0 Custom Variant and Variant Library Synthesis for SHROOM4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300579   
    OMIM disorders: 300434  
    UniProtKB/Swiss-Prot: SHRM4_HUMAN, Q9ULL8
  • Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX) [MIM:300434]: A syndrome
    characterized by severe mental retardation with hyperactivity, aggressive behavior, delayed or no speech, and
    seizures. Additional features include congenital bilateral hip luxation, short stature, and kyphosis. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR).
    Translocation t(X;8)(p11.22;p23.3) with FBXO25
  • Note=A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR).
    Translocation t(X;19)

  • 1 disease for SHROOM4:    
    About MalaCards
    stocco dos santos syndrome


    Find genes that share disorders with SHROOM4           About GenesLikeMe

    Genetic Association Database (GAD): SHROOM4

    Export disorders for SHROOM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHROOM4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SHROOM4)
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    1. A new standard nomenclature for proteins related to Apx and Shroom. (PubMed id 16615870)1, 2, 3 Hagens O....Wallingford J.B. (BMC Cell Biol. 2006)
    2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    3. Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation. (PubMed id 16249884)1, 2 Hagens O.... Hanauer A. (Hum. Genet. 2006)
    4. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. (PubMed id 16684770)1, 2 Dietz M.L.... Hildebrand J.D. (J. Biol. Chem. 2006)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    7. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57477 HGNC: 29215 AceView: KIAA1202 Ensembl:ENSG00000158352 euGenes: HUgn57477
    ECgene: SHROOM4 H-InvDB: SHROOM4

    (According to HUGE)
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    HUGE: KIAA1202

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SHROOM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SHROOM4 gene:
    Search GeneIP for patents involving SHROOM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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