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SHROOM3 Gene

protein-coding   GIFtS: 54
GCID: GC04P077356

Shroom Family Member 3

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shroom Family Member 31 2     ShrmL2
Shroom-Related Protein2 3     F-Actin-Binding Protein2
SHRM2 5     Protein Shroom32
KIAA14813 5     SHRML3
APXL32     hShrmL3

External Ids:    HGNC: 304221   Entrez Gene: 576192   Ensembl: ENSG000001387717   OMIM: 6045705   UniProtKB: Q8TF723   

Export aliases for SHROOM3 gene to outside databases

Previous GC identifers: GC04P077575 GC04P073108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHROOM3 Gene:
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This
protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for
proper neurulation. (provided by RefSeq, Jan 2011)

GeneCards Summary for SHROOM3 Gene:
SHROOM3 (shroom family member 3) is a protein-coding gene. Diseases associated with SHROOM3 include heterotaxy, and eosinophilic esophagitis. GO annotations related to this gene include actin binding. An important paralog of this gene is SHROOM1.

UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72
Function: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical
constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by
bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the
assembly of robust apicobasal microtubule arrays (By similarity)

Gene Wiki entry for SHROOM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SHROOM3 gene promoter:
         HSF1 (long)   CUTL1   STAT5A   LCR-F1   GATA-1   POU2F1   HSF2   POU2F1a   c-Myb   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHROOM3 promoter sequence
   Search Chromatin IP Primers for SHROOM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHROOM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SHROOM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHROOM3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P077356:  view genomic region     (about GC identifiers)

Start:
77,356,253 bp from pter      End:
77,704,406 bp from pter
Size:
348,154 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72 (See protein sequence)
Recommended Name: Protein Shroom3  
Size: 1996 amino acids; 216857 Da
Subunit: Interacts with F-actin (By similarity)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the
orthologs
Sequence caution: Sequence=AAQ13515.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB84689.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5QTQ3 Q6ZRW3 Q96IR9 Q9P247
Alternative splicing: 2 isoforms:  Q8TF72-1   Q8TF72-2   

Explore the universe of human proteins at neXtProt for SHROOM3: NX_Q8TF72

Explore proteomics data for SHROOM3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SHROOM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065910.3  
    ENSEMBL proteins: 
     ENSP00000296043  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014800 ASD1
     IPR027685 Shroom_fam
     IPR001478 PDZ
     IPR014799 ASD2

    Graphical View of Domain Structure for InterPro Entry Q8TF72

    ProtoNet protein and cluster: Q8TF72

    UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72
    Domain: The ASD1 domain mediates F-actin binding (By similarity)
    Domain: The ASD2 domain is required for apical constriction induction (By similarity)
    Similarity: Belongs to the shroom family
    Similarity: Contains 1 ASD1 domain
    Similarity: Contains 1 ASD2 domain
    Similarity: Contains 1 PDZ (DHR) domain


    SHROOM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHRM3_HUMAN, Q8TF72
    Function: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical
    constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by
    bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the
    assembly of robust apicobasal microtubule arrays (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    SHROOM3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Shroom3):
     craniofacial  digestive/alimentary  embryogenesis  growth/size/body  liver/biliary system 
     mortality/aging  nervous system  skeleton 

    SHROOM3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHROOM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHROOM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHROOM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHROOM3

    miRNA
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    miRTarBase miRNAs that target SHROOM3:
    hsa-mir-335-5p (MIRT019043)

    Block miRNA regulation of human, mouse, rat SHROOM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHROOM3 (see all 37):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-10b* hsa-miR-9 hsa-miR-424 hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidSHROOM3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHROOM3

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    GenScript: all cDNA clones in your preferred vector: SHROOM3 (NM_020859)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHROOM3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SHROOM3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHROOM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHRM3_HUMAN, Q8TF72: Cell junction, adherens junction (By similarity). Cytoplasm, cytoskeleton (By similarity).
    Note=Colocalizes with F-actin in stress fibers and adherens junctions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ISS--
    GO:0005874microtubule IEA--
    GO:0005912adherens junction ISS--
    GO:0016324apical plasma membrane ISS--

    SHROOM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHROOM3
    Interactions:

        Search GeneGlobe Interaction Network for SHROOM3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for SHROOM3 (Q8TF722, 3 ENSP000002960434) via UniProtKB, MINT, STRING, and/or I2D (see all 780)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3975290 I2D: score=2 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ISS--
    GO:0001843neural tube closure IEA--
    GO:0002066columnar/cuboidal epithelial cell development IEA--
    GO:0007389pattern specification process ISS--
    GO:0008360regulation of cell shape IEA--

    SHROOM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHROOM3 (SHRM3)

    5 Novoseek inferred chemical compound relationships for SHROOM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lsp 1 88.7 4 8995217 (1), 15684321 (1), 17296787 (1), 10925289 (1)
    gtp 33.9 2 10947844 (1), 11952837 (1)
    tyrosine 25.1 2 15186216 (1), 16912177 (1)
    gdp 20.4 2 10947844 (1), 11952837 (1)
    testosterone 0 1 10786829 (1)



    SHROOM3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHROOM3 gene: 
    NM_020859.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296043(uc011cbx.2 uc003hkg.3) ENST00000497440 ENST00000466541
    ENST00000469923 ENST00000490690 ENST00000481002 ENST00000485780 ENST00000484236
    ENST00000486758(uc011cbz.1 uc003hkf.1) ENST00000473602

    miRNA
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    Block miRNA regulation of human, mouse, rat SHROOM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHROOM3 (see all 37):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-10b* hsa-miR-9 hsa-miR-424 hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidSHROOM3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SHROOM3
    Predesigned siRNA for gene silencing in human, mouse, rat SHROOM3
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    OriGene clones in human, mouse for SHROOM3 (see all 9)
    OriGene ORF clones in mouse, rat for SHROOM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SHROOM3 (NM_020859)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHROOM3
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      QuantiTect SYBR Green Assays in human, mouse, rat SHROOM3
      QuantiFast Probe-based Assays in human, mouse, rat SHROOM3

    Selected AceView cDNA sequences (see all 168):

    BM128697 AI094154 Z38814 BP368535 AW513102 AA088672 AI088199 AW590275 
    AA534553 CA943687 BP356029 CB132332 AI911453 BC007291 AW005022 AB040914 
    AK128677 BU737776 AI650767 CK906265 CK903366 AI589124 AA604011 AA832508 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHROOM3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^
    SP1:                    -     -     -     -     -     -     -     -     -     -     -           -           -                       -                           
    SP2:                                                                                                                                -                           
    SP3:                    -     -     -     -     -     -     -     -     -     -     -           -           -     -     -     -     -                           
    SP4:                                                                                            -           -                                                   
    SP5:                                                        -                                                                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SHROOM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHROOM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTAATAA
    SHROOM3 Expression
    About this image


    SHROOM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Eye (Sensory Organs)
             Lens Pit Cells Lens Pit
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesoderm Cells Mesoderm
             Mesoderm
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Neural Ectoderm (Nervous System)
             Neural Plate
     
     Gonad
             Primary Oocyte Primary Follicle
    SHROOM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHROOM3 Protein Expression
        Custom PCR Arrays for SHROOM3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHROOM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHROOM3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shroom31 , 5 shroom family member 31, 5 78.43(n)1
    73.44(a)1
      5 (47.29 cM)5
    274281  NM_015756.21  NP_056571.21 
     926834355 
    chicken
    (Gallus gallus)
    Aves SHROOM31 shroom family member 3 60.73(n)
    54.57(a)
      422636  XM_420592.4  XP_420592.4 
    lizard
    (Anolis carolinensis)
    Reptilia SHROOM36
    shroom family member 3
    47(a)
    1 ↔ 1
    5(146474690-146497405)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.56222 X.laevis mRNA encoding apical protein 76.86(n)    Z14997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SHROOM36
    shroom family member 3
    56(a)
    1 ↔ 1
    Zv9_NA784(1600-11645) ENSDARG00000090422
    fruit fly
    (Drosophila melanogaster)
    Insecta Shroom6
    Shroom
    18(a)
    1 → many
    2R(10195667-10239312)


    ENSEMBL Gene Tree for SHROOM3 (if available)
    TreeFam Gene Tree for SHROOM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHROOM3 gene
    SHROOM12  SHROOM42  SHROOM22  
    1 SIMAP similar gene for SHROOM3 using alignment to 1 protein entry:     SHRM3_HUMAN:
    DKFZp781J074

    SHROOM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHROOM3 (see all 5452)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425813671,2
    Cuntested177478906(+) GAGGTG/AGCCTC 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
    rs712124221,2
    C--73107664(+) TTTTT-/T/TTTT
            
    GTCTT
    1 -- us2k11NA 2
    rs131478441,2
    A--73114502(+) AtttgG/Tttttt 1 -- int1 trp30--------
    rs58595131,2
    C--73119738(+) CTGGT-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs3680871911,2
    C--73119831(+) GGCGG-/CGGT  
            
    GGGGG
    1 -- int10--------
    rs50105131,2
    C,F,A--73119840(+) GGGGGG/ATGCAC 1 -- int15Minor allele frequency- A:0.30NA WA CSA 10
    rs3732300751,2
    C--73119840(+) GGGGG-/A/G/TG
            
    TGCAC
    1 -- int10--------
    rs358377651,2
    C--73166703(+) ATCTC-/AAAAAA 1 -- int10--------
    rs58595181,2
    C--73181036(+) TTTTT-/C/TGAGAT 1 -- int1 trp30--------
    rs669630731,2
    C,F--73195664(+) TTTTTT/AAATGT 1 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for SHROOM3 (77356253 - 77606253 bp, first 250kb of SHROOM3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SHROOM3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664574CNV Deletion23128226
    esv2727847CNV Deletion23290073
    esv2727846CNV Deletion23290073
    nsv289572CNV Insertion16902084
    nsv829972CNV Loss17160897
    nsv829973CNV Loss17160897
    esv275302CNV Loss21479260
    nsv292270CNV Loss16902084
    essv8045CNV CNV17122850
    essv12957CNV CNV17122850

    Human Gene Mutation Database (HGMD): SHROOM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHROOM3
    DNA2.0 Custom Variant and Variant Library Synthesis for SHROOM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604570    OMIM disorders: --

    18 diseases for SHROOM3:    
    About MalaCards
    heterotaxy    eosinophilic esophagitis    ocular albinism    wiskott-aldrich syndrome
    albinism    spina bifida    neurofibromatosis    amyotrophic lateral sclerosis
    lateral sclerosis    kidney disease    esophagitis    alzheimer's disease
    prostate cancer    prostatitis    hiv-1    colorectal cancer
    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SHROOM3:
    Ocular albinism

    SHROOM3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for SHROOM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 42 1 12534372 (1)
    metastasis 0 1 16912177 (1)
    tumors 0 2 16912177 (1), 8089100 (1)
    alzheimers disease 0 1 16325786 (1)

    Genetic Association Database (GAD): SHROOM3
    Human Genome Epidemiology (HuGE) Navigator: SHROOM3 (6 documents)

    Export disorders for SHROOM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHROOM3 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with SHROOM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new standard nomenclature for proteins related to Apx and Shroom. (PubMed id 16615870)1, 2, 3 Hagens O....Wallingford J.B. (BMC Cell Biol. 2006)
    2. Identification of interacting genes in genome-wide association studies using a model-based two-stage approach. (PubMed id 20636464)1, 4 Zhang Z....Sha Q. (Ann. Hum. Genet. 2010)
    3. Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2010)
    4. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PubMed id 20700443)1, 4 Meyer T.E.... . (PLoS Genet. 2010)
    7. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PubMed id 20208534)1, 4 Rothenberg M.E....Hakonarson H. (Nat. Genet. 2010)
    8. Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis. (PubMed id 19740415)1, 4 Sha Q....Zhang S. (BMC Med. Genet. 2009)
    9. Multiple loci associated with indices of renal function and chronic kidney disease. (PubMed id 19430482)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 57619 HGNC: 30422 AceView: ShrmL Ensembl:ENSG00000138771 euGenes: HUgn57619
    ECgene: SHROOM3 H-InvDB: SHROOM3

    (According to HUGE)
    About This Section

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    HUGE: KIAA1481

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SHROOM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SHROOM3 gene:
    Search GeneIP for patents involving SHROOM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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