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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHROOM3 Gene

protein-coding   GIFtS: 53
GCID: GC04P077356

shroom family member 3
 Explore 14 diseases affiliated with
SHROOM3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHROOM3    

Aliases
for SHROOM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Shroom Family Member 31 2     Shroom-Related Protein2 3
SHRM1 2 5     F-Actin-Binding Protein2
KIAA14811 3 5     Protein Shroom32
APXL31 2     SHRML3
ShrmL1 2     HShrmL1

External Ids:    HGNC: 304221   Entrez Gene: 576192   Ensembl: ENSG000001387717   OMIM: 6045705   UniProtKB: Q8TF723   

Export aliases for SHROOM3 gene to outside databases

Previous GC identifers: GC04P077575 GC04P073108


Summaries
for SHROOM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SHROOM3:
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may
be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation.
(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72
Function: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in
epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress
fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust
apicobasal microtubule arrays (By similarity)

Gene Wiki entry for SHROOM3


Genomic Views
for SHROOM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHROOM3 gene promoter:
         HSF1 (long)   CUTL1   STAT5A   LCR-F1   GATA-1   POU2F1   HSF2   POU2F1a   c-Myb   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SHROOM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHROOM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHROOM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.1

SHROOM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHROOM3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P077356:  view genomic region     (about GC identifiers)

Start:
 77,356,253 bp from pter      End:
 77,704,406 bp from pter
Size:
 348,154 bases      Orientation:
 plus strand

Proteins
for SHROOM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72 (See protein sequence)
Recommended Name: Protein Shroom3  
Size: 1996 amino acids; 216857 Da
Subunit: Interacts with F-actin (By similarity)
Subcellular location: Cell junction, adherens junction (By similarity). Cytoplasm, cytoskeleton (By similarity).
Note=Colocalizes with F-actin in stress fibers and adherens junctions (By similarity)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator. Met-2 is more conserved than Met-1 among the
orthologs
Sequence caution: Sequence=AAQ13515.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB84689.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q5QTQ3 Q6ZRW3 Q96IR9 Q9P247
Alternative splicing: 2 isoforms:  Q8TF72-1   Q8TF72-2   

Explore the universe of human proteins at neXtProt for SHROOM3: NX_Q8TF72

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TF72

    • SHROOM3 Protein expression data from MOPED and PaxDb:    About this image 
    SHROOM3 Protein Expression
    REFSEQ proteins: NP_065910.3  
    ENSEMBL proteins: 
     ENSP00000296043  

    Human Recombinant Protein Products for SHROOM3: 
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    Uscn Proteins for SHROOM3

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ISS--
    GO:0005874microtubule IEA--
    GO:0005912adherens junction ISS--
    GO:0016324apical plasma membrane ISS--

    SHROOM3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SHROOM3

    Protein Domains /
    Families
    for SHROOM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHROOM3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001478 PDZ
     IPR014799 ASD2
     IPR014800 ASD1

    Graphical View of Domain Structure for InterPro Entry Q8TF72

    ProtoNet protein and cluster: Q8TF72

    UniProtKB/Swiss-Prot: SHRM3_HUMAN, Q8TF72
    Domain: The ASD1 domain mediates F-actin binding (By similarity)
    Domain: The ASD2 domain is required for apical constriction induction (By similarity)
    Similarity: Belongs to the shroom family
    Similarity: Contains 1 ASD1 domain
    Similarity: Contains 1 ASD2 domain
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for SHROOM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHRM3_HUMAN, Q8TF72
    Function: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in
    epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress
    fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust
    apicobasal microtubule arrays (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    SHROOM3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Shroom3):
     craniofacial  digestive/alimentary  embryogenesis  growth/size  liver/biliary system 
     mortality/aging  nervous system  skeleton 

    SHROOM3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SHROOM3 

    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SHROOM3 (see all 37):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-10b* hsa-miR-9 hsa-miR-424 hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmid: SHROOM3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHROOM3 (see all 4)
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for SHROOM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHROOM3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/744 Interacting proteins for SHROOM3 (Q8TF722, 3 ENSP000002960434) via UniProtKB, MINT, STRING, and/or I2D (see all 744)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3975290 I2D: score=2 
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ISS--
    GO:0001843neural tube closure IEA--
    GO:0002066columnar/cuboidal epithelial cell development IEA--
    GO:0007389pattern specification process ISS--
    GO:0008360regulation of cell shape IEA--

    SHROOM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHROOM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHROOM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SHROOM3
    5 Novoseek chemical compound relationships for SHROOM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lsp 1 88.7 4 8995217 (1), 15684321 (1), 17296787 (1), 10925289 (1)
    gtp 33.9 2 10947844 (1), 11952837 (1)
    tyrosine 25.1 2 15186216 (1), 16912177 (1)
    gdp 20.4 2 10947844 (1), 11952837 (1)
    testosterone 0 1 10786829 (1)

    Search CenterWatch for drugs/clinical trials and news about SHROOM3 / SHRM3 

    Transcripts
    for SHROOM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHROOM3 gene: 
    NM_020859.3  

    Unigene Cluster for SHROOM3:

    Shroom family member 3
    Hs.702168  [show with all ESTs]
    Unigene Representative Sequence: NM_020859
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296043(uc011cbx.2 uc003hkg.3) ENST00000497440 ENST00000466541
    ENST00000469923 ENST00000490690 ENST00000481002 ENST00000485780 ENST00000484236
    ENST00000486758(uc011cbz.1 uc003hkf.1) ENST00000473602

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHROOM3
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate SHROOM3 (see all 37):
    hsa-miR-140-5p hsa-miR-3678-3p hsa-miR-15a hsa-miR-371-5p hsa-miR-10b* hsa-miR-9 hsa-miR-424 hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmid: SHROOM3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHROOM3 (see all 4)
    OriGene shRNA RFP: SHROOM3
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB040914.1 AB055660.1 AF109367.1 AK027744.1 AK055294.1 AK124415.1 AK127929.1 AK128677.1 
    AK304103.1 BC007291.1 

    16 DOTS entries:

    DT.452735  DT.101955079  DT.95340156  DT.97816667  DT.434390  DT.75185830  DT.121245435  DT.121245441 
    DT.100740647  DT.100779106  DT.102826412  DT.121245415  DT.75116819  DT.75181070  DT.95339196  DT.100647380 

    24/168 AceView cDNA sequences (see all 168):

    BC007291 AB040914 AW005022 CK906265 BU737776 AI650767 CK903366 AA604011 
    BM129196 BQ777531 AA832508 BX095640 CK906264 BP354151 AA678928 AK128677 
    AI911453 AI589124 D79937 CB132332 CA943687 AA088672 AI088199 BP356029 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SHROOM3 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^
    SP1:                    -     -     -     -     -     -     -     -     -     -     -           -           -                       -                           
    SP2:                                                                                                                                -                           
    SP3:                    -     -     -     -     -     -     -     -     -     -     -           -           -     -     -     -     -                           
    SP4:                                                                                            -           -                                                   
    SP5:                                                        -                                                                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SHROOM3

    Expression
    for SHROOM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHROOM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTTAATAA
    SHROOM3 Expression
    About this image

    SHROOM3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)

    See SHROOM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHROOM3

    SOURCE GeneReport for Unigene cluster: Hs.702168
        SABiosciences Custom PCR Arrays for SHROOM3
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    In Situ
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    Orthologs
    for SHROOM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHROOM3 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SHROOM31 shroom family member 3 60.36(n)
    54.54(a)    		   422636  XM_420592.3  XP_420592.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SHROOM36
    		 --
    		 43(a)
    		 1 ↔ 1
    		 5(146474768-146497405)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.56222 X.laevis mRNA encoding apical protein 76.86(n)    Z14997.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01085454.16
    CU694445.16
    		 --
    		 57(a)
    30(a)
    		 possible ortholog
    possible ortholog
    		 Zv9_NA784(1600-11645)
    17(49838893-49975823)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Shroom6
    		 Shroom
    		 14(a)
    		 1 → many
    		 2R(10195667-10239312)


    ENSEMBL Gene Tree for SHROOM3 (if available)
    TreeFam Gene Tree for SHROOM3 (if available) 

    Paralogs
    for SHROOM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHROOM3 gene
    SHROOM12  SHROOM42  SHROOM22  
    1 SIMAP similar gene for SHROOM3 using alignment to 1 protein entry:     SHRM3_HUMAN:
    DKFZp781J074

    SHROOM3 for paralogs           About GeneDecksing



    Genomic Variants
    for SHROOM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5556 NCBI SNPs in SHROOM3 are shown (see all 5556)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425813671,2
    		Cother73412518(+) GAGGTG/AGCCTC 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
    rs782793821,2
    		F--73106626(+) ACACCT/AGACTT 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs794451801,2
    		--73106633(+) ACTTAA/TGCTAG 1 -- us2k12Minor allele frequency- T:0.16CSA WA 120
    rs76745671,2
    		C,F,A,H--73106654(+) CTAAAC/TGTCTG 1 -- us2k15Minor allele frequency- T:0.04NS EA CSA WA 382
    rs748497901,2
    		--73106712(+) GTCAGA/TTCATT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs728646081,2
    		C--73106840(+) TCCAAT/ACCTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs791875351,2
    		--73107845(+) CTTCAG/CTTTTC 1 -- us2k12Minor allele frequency- C:0.13CSA WA 120
    rs68278181,2
    		C,F,H--73107901(+) AGTACA/GTATAT 1 -- us2k19Minor allele frequency- G:0.13NS NA CSA WA 1014
    rs1119059411,2
    		C--73107927(+) CTAATC/ATGTTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs612920791,2
    		--73108132(+) AAAGAA/GTGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SHROOM3 (77356253 - 77606253 bp, first 250kb of SHROOM3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SHROOM3
         4 CNVs: 92204 6281 2532 3500
         1 Indel: 60478
    Human Gene Mutation Database (HGMD): SHROOM3

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    Disorders / Diseases
    for SHROOM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHROOM3 for disorders           About GeneDecksing

    OMIM gene information: 604570    OMIM disorders: --

    14 diseases for SHROOM3:    About MalaCards
    wiskott-aldrich syndrome    spina bifida    ocular albinism    amyotrophic lateral sclerosis
    lateral sclerosis    hearing loss    albinism    neurofibromatosis
    kidney disease    prostate cancer    esophagitis    prostatitis
    neuronitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SHROOM3:
    Ocular albinism

    4 Novoseek disease relationships for SHROOM3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 42 1 12534372 (1)
    metastasis 0 1 16912177 (1)
    tumors 0 2 16912177 (1), 8089100 (1)
    alzheimers disease 0 1 16325786 (1)

    Human Genome Epidemiology (HuGE) Navigator: SHROOM3 (6 documents)

    Export disorders for SHROOM3 gene to outside databases

    Publications
    for SHROOM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHROOM3 gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with SHROOM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new standard nomenclature for proteins related to Apx and Shroom. (PubMed id 16615870)1, 2, 3 Hagens O....Wallingford J.B. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    4. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. (PubMed id 10589677)1, 3 Hildebrand J.D. and Soriano P. (1999)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
    7. SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing. (PubMed id 21936905)1 Tariq M....Ware S.M. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Identification of interacting genes in genome-wide as sociation studies using a model-based two-stage approach. (PubMed id 20636464)1 Zhang Z....Sha Q. (2010)

    External Searches for SHROOM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SHROOM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57619 HGNC: 30422 AceView: ShrmL Ensembl:ENSG00000138771 euGenes: HUgn57619
    ECgene: SHROOM3 H-InvDB: SHROOM3

    Other Databases showing SHROOM3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1481

    Specialized Databases showing SHROOM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHROOM3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHROOM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHROOM3 gene:
    Search GeneIP for patents involving SHROOM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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