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Aliases for SHROOM1 Gene

Aliases for SHROOM1 Gene

  • Shroom Family Member 1 2 3 5
  • Apical Protein 2 3 4
  • APXL2 3 4
  • Protein Shroom1 3
  • KIAA1960 4

External Ids for SHROOM1 Gene

Previous GeneCards Identifiers for SHROOM1 Gene

  • GC05M132186
  • GC05M132157
  • GC05M127350

Summaries for SHROOM1 Gene

Entrez Gene Summary for SHROOM1 Gene

  • SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SHROOM1 Gene

SHROOM1 (Shroom Family Member 1) is a Protein Coding gene. Among its related pathways are Tight junction. GO annotations related to this gene include actin filament binding. An important paralog of this gene is SHROOM3.

UniProtKB/Swiss-Prot for SHROOM1 Gene

  • May be involved in the assembly of microtubule arrays during cell elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHROOM1 Gene

Genomics for SHROOM1 Gene

Regulatory Elements for SHROOM1 Gene

Enhancers for SHROOM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F132836 0.9 Ensembl ENCODE 17.7 -7.8 -7813 5.3 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 CBX5 FOS PAF1 SHROOM1 GDF9 GC05M132843
GH05F132800 0.3 FANTOM5 13.8 +30.9 30910 0.3 SEPT8 KIF3A SHROOM1 CCNI2 ENSG00000230612 SOWAHA GC05M132776 GC05M132777
GH05F132780 0.8 FANTOM5 13.3 +51.5 51474 0.2 SEPT8 KIF3A SHROOM1 SOWAHA CCNI2 TH2LCRR IL13 RNU7-15P RNA5SP192 IL4
GH05F132853 0.9 ENCODE 12 -21.9 -21893 0.2 SAP130 ATF3 FOXA3 ZBTB33 RARA YY1 ZKSCAN1 SHROOM1 RNA5SP192 UQCRQ
GH05F132877 0.5 ENCODE 11.9 -46.7 -46671 0.8 OSR2 ZNF664 NFIA SP2 PRDM10 ZBTB8A ZXDB GDF9 SHROOM1 RNA5SP192 RNU7-15P ENSG00000230612 LEAP2 GC05P132913
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SHROOM1 on UCSC Golden Path with GeneCards custom track

Promoters for SHROOM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001413957 1221 1601 ATF1 CREB3L1 ARID4B SIN3A GLI4 ZNF48 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for SHROOM1 Gene

Chromosome:
5
Start:
132,822,141 bp from pter
End:
132,831,621 bp from pter
Size:
9,481 bases
Orientation:
Minus strand

Genomic View for SHROOM1 Gene

Genes around SHROOM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHROOM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHROOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHROOM1 Gene

Proteins for SHROOM1 Gene

  • Protein details for SHROOM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3G4-SHRM1_HUMAN
    Recommended name:
    Protein Shroom1
    Protein Accession:
    Q2M3G4
    Secondary Accessions:
    • B7WP40
    • B7ZL01
    • Q8TDP0
    • Q8TF41

    Protein attributes for SHROOM1 Gene

    Size:
    852 amino acids
    Molecular mass:
    90786 Da
    Quaternary structure:
    • Interacts with F-actin.
    SequenceCaution:
    • Sequence=BAB85546.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SHROOM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHROOM1 Gene

Post-translational modifications for SHROOM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SHROOM1 Gene

Domains & Families for SHROOM1 Gene

Protein Domains for SHROOM1 Gene

Suggested Antigen Peptide Sequences for SHROOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M3G4

UniProtKB/Swiss-Prot:

SHRM1_HUMAN :
  • The ASD1 domain mediates F-actin binding.
  • Belongs to the shroom family.
Domain:
  • The ASD1 domain mediates F-actin binding.
  • Contains 1 ASD1 domain.
  • Contains 1 ASD2 domain.
Family:
  • Belongs to the shroom family.
genes like me logo Genes that share domains with SHROOM1: view

No data available for Gene Families for SHROOM1 Gene

Function for SHROOM1 Gene

Molecular function for SHROOM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the assembly of microtubule arrays during cell elongation.

Gene Ontology (GO) - Molecular Function for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0051015 actin filament binding ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view
genes like me logo Genes that share phenotypes with SHROOM1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHROOM1 Gene

Localization for SHROOM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHROOM1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHROOM1 Gene COMPARTMENTS Subcellular localization image for SHROOM1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0016460 colocalizes_with myosin II complex ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view

Pathways & Interactions for SHROOM1 Gene

SuperPathways for SHROOM1 Gene

SuperPathway Contained pathways
1 Tight junction
genes like me logo Genes that share pathways with SHROOM1: view

Pathways by source for SHROOM1 Gene

1 KEGG pathway for SHROOM1 Gene

Interacting Proteins for SHROOM1 Gene

Gene Ontology (GO) - Biological Process for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS 16684770
GO:0051017 actin filament bundle assembly ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view

No data available for SIGNOR curated interactions for SHROOM1 Gene

Transcripts for SHROOM1 Gene

Unigene Clusters for SHROOM1 Gene

Shroom family member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHROOM1 Gene

No ASD Table

Relevant External Links for SHROOM1 Gene

GeneLoc Exon Structure for
SHROOM1
ECgene alternative splicing isoforms for
SHROOM1

Expression for SHROOM1 Gene

mRNA expression in normal human tissues for SHROOM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHROOM1 Gene

This gene is overexpressed in Liver (x9.6), Bladder (x6.6), and Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for SHROOM1 Gene

This gene is overexpressed in Fetal gut (14.6), Adrenal (11.0), CD8 Tcells (8.8), and Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SHROOM1 Gene



Protein tissue co-expression partners for SHROOM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SHROOM1 Gene:

SHROOM1

SOURCE GeneReport for Unigene cluster for SHROOM1 Gene:

Hs.519574
genes like me logo Genes that share expression patterns with SHROOM1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SHROOM1 Gene

Orthologs for SHROOM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHROOM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHROOM1 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia SHROOM1 34 35
  • 81.88 (n)
dog
(Canis familiaris)
Mammalia SHROOM1 34 35
  • 80.68 (n)
rat
(Rattus norvegicus)
Mammalia Shroom1 34
  • 74.21 (n)
mouse
(Mus musculus)
Mammalia Shroom1 34 16 35
  • 73.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SHROOM1 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 16 (a)
OneToMany
-- 35
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SHROOM1 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii shroom1 35
  • 12 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Shroom 35
  • 9 (a)
OneToMany
Species where no ortholog for SHROOM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHROOM1 Gene

ENSEMBL:
Gene Tree for SHROOM1 (if available)
TreeFam:
Gene Tree for SHROOM1 (if available)

Paralogs for SHROOM1 Gene

Paralogs for SHROOM1 Gene

genes like me logo Genes that share paralogs with SHROOM1: view

Variants for SHROOM1 Gene

Sequence variations from dbSNP and Humsavar for SHROOM1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10054043 -- 132,826,092(+) GCTAG(C/T)GGACG nc-transcript-variant, reference, missense
rs10440782 -- 132,827,855(+) GGTAC(A/G)AACAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs10440783 -- 132,828,277(+) CTACA(A/G)CATTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111586181 -- 132,824,674(+) AGTGG(C/G)GCCTC nc-transcript-variant, reference, synonymous-codon
rs111886759 -- 132,826,526(+) CTCCC(C/T)AACCC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SHROOM1 Gene

Variant ID Type Subtype PubMed ID
esv1003435 CNV deletion 20482838
esv3890740 CNV loss 25118596
nsv830489 CNV loss 17160897
nsv950395 CNV deletion 24416366

Variation tolerance for SHROOM1 Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.97; 68.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHROOM1 Gene

Human Gene Mutation Database (HGMD)
SHROOM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHROOM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHROOM1 Gene

Disorders for SHROOM1 Gene

Relevant External Links for SHROOM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHROOM1

No disorders were found for SHROOM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHROOM1 Gene

Publications for SHROOM1 Gene

  1. A new standard nomenclature for proteins related to Apx and Shroom. (PMID: 16615870) Hagens O. … Wallingford J.B. (BMC Cell Biol. 2006) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Identification of differentially methylated regions in new genes associated with knee osteoarthritis. (PMID: 26484395) Bonin C.A. … Westendorf J.J. (Gene 2016) 3 64
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SHROOM1 Gene

Sources for SHROOM1 Gene

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