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Aliases for SHROOM1 Gene

Aliases for SHROOM1 Gene

  • Shroom Family Member 1 2 3
  • APXL2 3 4 6
  • Apical Protein 2 3 4
  • KIAA1960 4 6
  • Protein Shroom1 3

External Ids for SHROOM1 Gene

Previous GeneCards Identifiers for SHROOM1 Gene

  • GC05M132186
  • GC05M132157
  • GC05M127350

Summaries for SHROOM1 Gene

Entrez Gene Summary for SHROOM1 Gene

  • SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SHROOM1 Gene

SHROOM1 (Shroom Family Member 1) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is SHROOM2.

UniProtKB/Swiss-Prot for SHROOM1 Gene

  • May be involved in the assembly of microtubule arrays during cell elongation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHROOM1 Gene

Genomics for SHROOM1 Gene

Regulatory Elements for SHROOM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHROOM1 Gene

132,822,141 bp from pter
132,830,958 bp from pter
8,818 bases
Minus strand

Genomic View for SHROOM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHROOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHROOM1 Gene

Proteins for SHROOM1 Gene

  • Protein details for SHROOM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Shroom1
    Protein Accession:
    Secondary Accessions:
    • B7WP40
    • B7ZL01
    • Q8TDP0
    • Q8TF41

    Protein attributes for SHROOM1 Gene

    852 amino acids
    Molecular mass:
    90786 Da
    Quaternary structure:
    • Interacts with F-actin.
    • Sequence=BAB85546.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SHROOM1 Gene


neXtProt entry for SHROOM1 Gene

Proteomics data for SHROOM1 Gene at MOPED

Post-translational modifications for SHROOM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHROOM1 Gene

No data available for DME Specific Peptides for SHROOM1 Gene

Domains for SHROOM1 Gene

Protein Domains for SHROOM1 Gene


Suggested Antigen Peptide Sequences for SHROOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2M3G4
  • The ASD1 domain mediates F-actin binding.
  • Contains 1 ASD1 domain.
  • Contains 1 ASD2 domain.
  • Belongs to the shroom family.
genes like me logo Genes that share domains with SHROOM1: view

No data available for Gene Families for SHROOM1 Gene

Function for SHROOM1 Gene

Molecular function for SHROOM1 Gene

UniProtKB/Swiss-Prot Function: May be involved in the assembly of microtubule arrays during cell elongation.

Gene Ontology (GO) - Molecular Function for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view

Phenotypes for SHROOM1 Gene

GenomeRNAi human phenotypes for SHROOM1:
genes like me logo Genes that share phenotypes with SHROOM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHROOM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHROOM1 Gene

Localization for SHROOM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHROOM1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for SHROOM1 Gene COMPARTMENTS Subcellular localization image for SHROOM1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0016460 colocalizes_with myosin II complex ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view

Pathways for SHROOM1 Gene

SuperPathways for SHROOM1 Gene

No Data Available

Interacting Proteins for SHROOM1 Gene

Gene Ontology (GO) - Biological Process for SHROOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS 16684770
GO:0051017 actin filament bundle assembly ISS 16684770
genes like me logo Genes that share ontologies with SHROOM1: view

No data available for Pathways by source for SHROOM1 Gene

Transcripts for SHROOM1 Gene

Unigene Clusters for SHROOM1 Gene

Shroom family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHROOM1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHROOM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHROOM1 Gene

No ASD Table

Relevant External Links for SHROOM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHROOM1 Gene

mRNA expression in normal human tissues for SHROOM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHROOM1 Gene

This gene is overexpressed in Liver (9.6), Bladder (6.6), and Prostate (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHROOM1 Gene

SOURCE GeneReport for Unigene cluster for SHROOM1 Gene Hs.519574

genes like me logo Genes that share expressions with SHROOM1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SHROOM1 Gene

Orthologs for SHROOM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SHROOM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHROOM1 35
  • 99.33 (n)
  • 98.94 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SHROOM1 35
  • 81.88 (n)
  • 73.07 (a)
  • 72 (a)
(Canis familiaris)
Mammalia SHROOM1 35
  • 80.68 (n)
  • 70.97 (a)
  • 70 (a)
(Mus musculus)
Mammalia Shroom1 35
  • 73.45 (n)
  • 62.71 (a)
Shroom1 16
Shroom1 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SHROOM1 36
  • 32 (a)
(Rattus norvegicus)
Mammalia Shroom1 35
  • 74.21 (n)
  • 63.78 (a)
(Gallus gallus)
Aves -- 36
  • 16 (a)
-- 36
  • 14 (a)
(Anolis carolinensis)
Reptilia SHROOM1 36
  • 42 (a)
(Danio rerio)
Actinopterygii shroom1 36
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Shroom 36
  • 9 (a)
Species with no ortholog for SHROOM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHROOM1 Gene

Gene Tree for SHROOM1 (if available)
Gene Tree for SHROOM1 (if available)

Paralogs for SHROOM1 Gene

Paralogs for SHROOM1 Gene

genes like me logo Genes that share paralogs with SHROOM1: view

Variants for SHROOM1 Gene

Sequence variations from dbSNP and Humsavar for SHROOM1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2292030 - 132,825,602(-) GCCCC(C/T)GGCGA reference, missense, nc-transcript-variant
rs4705870 -- 132,823,442(+) GCCCA(C/T)GCTTG synonymous-codon, reference, downstream-variant-500B
rs10054043 -- 132,826,092(+) GCTAG(C/T)GGACG reference, missense, nc-transcript-variant
rs12110206 -- 132,827,084(+) TGGGC(C/T)GACCC intron-variant, upstream-variant-2KB
rs13179709 -- 132,825,897(+) cgggg(A/T)TGTGC missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SHROOM1 Gene

Variant ID Type Subtype PubMed ID
nsv882919 CNV Gain 21882294
nsv882920 CNV Loss 21882294
nsv830489 CNV Loss 17160897
esv1003435 CNV Deletion 20482838

Relevant External Links for SHROOM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHROOM1 Gene

Disorders for SHROOM1 Gene

No disorders were found for SHROOM1 Gene.

No data available for UniProtKB/Swiss-Prot for SHROOM1 Gene

Publications for SHROOM1 Gene

  1. A new standard nomenclature for proteins related to Apx and Shroom. (PMID: 16615870) Hagens O. … Wallingford J.B. (BMC Cell Biol. 2006) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. (PMID: 16684770) Dietz M.L. … Hildebrand J.D. (J. Biol. Chem. 2006) 3
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 4

Products for SHROOM1 Gene

Sources for SHROOM1 Gene

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