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SHQ1 Gene

protein-coding GIFtS: 50
GCID: GC03M072798

SHQ1, H/ACA Ribonucleoprotein Assembly Factor

(Previous name: SHQ1 homolog (S. cerevisiae))

See related disease
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
SHQ1, H/ACA Ribonucleoprotein Assembly Factor¹ ²
SHQ1 Homolog (S. Cerevisiae)¹
Shq1p²
Protein SHQ1 Homolog²
SHQ1 Homolog²

External Ids:	HGNC: 25543¹	Entrez Gene: 55164²	Ensembl: ENSG00000144736⁷	OMIM: 613663⁵	UniProtKB: Q6PI26³

Export aliases for SHQ1 gene to outside databases

Previous GC identifer: GC03M072883

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHQ1 Gene:

SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs,

modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et

al., 2009 (PubMed 19383767)).(supplied by OMIM, Dec 2010)

GeneCards Summary for SHQ1 Gene:

SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor) is a protein-coding gene. Diseases associated with SHQ1 include dyskeratosis congenita.

UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26

Function: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase,

probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10,

NHP2, and NAF1 at the nascent H/ACA RNA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000003.12 NC_018914.2 NT_022517.19

Regulatory elements:

Regulatory transcription factor binding sites in the SHQ1 gene promoter:
Nkx3-1 Nkx2-2 GCNF Nkx3-1 v1 CREB Nkx3-1 v2 deltaCREB GCNF-1 Nkx3-1 v3 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHQ1 promoter sequence

Search Chromatin IP Primers for SHQ1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHQ1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p13 Ensembl cytogenetic band: 3p13 HGNC cytogenetic band: 3p13

SHQ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHQ1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M072798: view genomic region (about GC identifiers)

Start:	72,798,428 bp from pter	End:	72,911,065 bp from pter
Size:	112,638 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26 (See protein sequence)

Recommended Name: Protein SHQ1 homolog

Size: 577 amino acids; 65125 Da

Subunit: Directly interacts with DKC1 alone, but not in the context of the core trimer composed of DKC1, NOP10 and

NHP2, nor in the presence of NAF1. Does not interact with NAF1

Sequence caution: Sequence=BAA91669.1; Type=Frameshift; Positions=79; Sequence=BAB14947.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

Secondary accessions: Q6MZJ4 Q7Z748 Q9H7E5 Q9NVS8

Explore the universe of human proteins at neXtProt for SHQ1: NX_Q6PI26

Explore proteomics data for SHQ1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See SHQ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060600.2

ENSEMBL proteins:

ENSP00000402447 ENSP00000315182 ENSP00000417452 ENSP00000418398 ENSP00000417739

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR007009 SHQ1

IPR008978 HSP20-like_chaperone

IPR007052 CS_dom

Graphical View of Domain Structure for InterPro Entry Q6PI26

ProtoNet protein and cluster: Q6PI26

UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26

Similarity: Belongs to the SHQ1 family

Similarity: Contains 1 CS domain

SHQ1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SHQ1_HUMAN, Q6PI26

Function: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase,

probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10,

NHP2, and NAF1 at the nascent H/ACA RNA

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19383767

SHQ1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SHQ1:

G0/1 arrest

Increased G1 DNA content

Animal Models:

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		hsa-miR-548m hsa-miR-875-3p hsa-miR-4261 hsa-miR-616* hsa-miR-373*
		SwitchGear 3'UTR luciferase reporter plasmid: SHQ1 3' UTR sequence

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Gene Editing
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SHQ1_HUMAN, Q6PI26: Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between

cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal

bodies. Absent from most H/ACA-box RNA transcription sites

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	5
nucleus	5

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Gene Ontology (GO): Selected cellular component terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	IDA	19383767
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	IEA	--

SHQ1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SHQ1
Interactions:

Search GeneGlobe Interaction Network for SHQ1

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for SHQ1 (Q6PI26³ ENSP00000315182⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WDR48	Q8TAF3³, ENSP00000307491⁴	I2D: score=2 STRING: ENSP00000307491
DKC1	O60832³, ENSP00000358563⁴	I2D: score=1 STRING: ENSP00000358563
MRTO4	Q9UKD2³, ENSP00000364320⁴	I2D: score=1 STRING: ENSP00000364320
NHP2	Q9NX24³, ENSP00000274606⁴	I2D: score=1 STRING: ENSP00000274606
RUVBL1	Q9Y265³, ENSP00000318297⁴	I2D: score=1 STRING: ENSP00000318297

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0022618	ribonucleoprotein complex assembly	IDA	19383767
GO:0043065	positive regulation of apoptotic process	IDA	--
GO:2000233	negative regulation of rRNA processing	IDA	--

SHQ1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SHQ1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SHQ1 gene:

NM_018130.2

Unigene Cluster for SHQ1:

SHQ1, H/ACA ribonucleoprotein assembly factor

Hs.606584 [show with all ESTs]

Unigene Representative Sequence: BX641074

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000468371 ENST00000444040 ENST00000325599(uc003dpf.3 uc010hod.3)

ENST00000463369 ENST00000475558 ENST00000468347 ENST00000482785 ENST00000471526

miRNA Products:		Block miRNA regulation of human, mouse, rat SHQ1 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate SHQ1:
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		QuantiFast Probe-based Assays in human, mouse, rat SHQ1

Additional mRNA sequence:

AK001401.1 AK092962.1 AK296789.1 BC017204.2 BC017274.2 BC025270.1 BC032671.1 BC039830.1

BC047879.2 BX641074.1

9 DOTS entries:

DT.91718956 DT.445698 DT.100779511 DT.95117942 DT.100841575 DT.208923 DT.91753157 DT.91850035

DT.97841561

Selected AceView cDNA sequences (see all 114):

AI476821 BM771281 BX370096 BX393619 AK092962 BC017204 BU161478 AL557000

AW070280 BC017274 AU117970 BX281969 AI151469 AW664464 BC039830 CR602146

BM786501 BG392630 CB216026 BM771386 BX645375 BC047879 AI570146 BC032671

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SHQ1 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12
SP1:							-																		-
SP2:																									-
SP3:							-		-
SP4:

ECgene alternative splicing isoforms for SHQ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SHQ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGTCACGAGT

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SHQ1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SHQ1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.606584

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHQ1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SHQ1 gene from Selected species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Shq1^{1 , 5}	SHQ1 homolog (S. cerevisiae)^{1, 5}	79.11(n)¹ 77.02(a)¹		6 (46.82 cM)⁵ 72171¹ NM_181590.4¹ NP_853621.2¹ 100573081⁵
chicken (Gallus gallus)	Aves	SHQ1¹	SHQ1 homolog (S. cerevisiae)	67.67(n) 63.78(a)		416096 XM_004944692.1 XP_004944749.1
lizard (Anolis carolinensis)	Reptilia	SHQ1⁶	SHQ1, H/ACA ribonucleoprotein assembly factor	54(a)	1 ↔ 1	2(179314553-179433668)
tropical clawed frog (Xenopus tropicalis)	Amphibia	shq1¹	SHQ1, H/ACA ribonucleoprotein assembly factor	60.52(n) 58.21(a)		780072 NM_001079148.1 NP_001072616.1
zebrafish (Danio rerio)	Actinopterygii	shq1¹	SHQ1 homolog (S. cerevisiae)	62.18(n) 61.35(a)		567601 NM_001080600.1 NP_001074069.1
fruit fly (Drosophila melanogaster)	Insecta	CG10055⁶	--	21(a)	1 ↔ 1	3R(3009823-3012375)
worm (Caenorhabditis elegans)	Secernentea	CELE_Y48A5A.1¹	CELE_Y48A5A.1	47.08(n) 38.9(a)		176997 NM_067749.3 NP_500150.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SHQ1(YIL104C)⁴ SHQ1¹	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones less⁴ SHQ1¹	46.02(n)¹ 30.71(a)¹		9(171505-169982)⁴ 854702^{1, 4} NP_012162.3¹ NP_012162.1⁴

ENSEMBL Gene Tree for SHQ1 (if available)
TreeFam Gene Tree for SHQ1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SHQ1 gene

SHQ1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SHQ1
PGOHUM00000238489

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142977745^1,2	C	--	72798040(+)	`GGGTGA/TGGCTG`	1	--	ds500¹		0	--	--	--	--
rs187508305^1,2	C	--	72798101(+)	`ACCCTA/GTCTCA`	1	--	ds500¹		0	--	--	--	--
rs192332845^1,2	C	--	72798116(+)	`CACACA/GCACAC`	1	--	ds500¹		0	--	--	--	--
rs34002344^1,2	C	--	72798122(+)	`ACACG-/CACACAC`	1	--	ds500¹		0	--	--	--	--
rs369102795^1,2	C	--	72798123(+)	`CACAC-/CAACACA`	1	--	ds500¹		0	--	--	--	--
rs202040923^1,2		--	72798148(+)	`CACAC-/ACAG GCAGA`	1	--	ds500¹		0	--	--	--	--
rs185558641^1,2		--	72798358(+)	`ACCTAA/CCATAT`	1	--	ds500¹		0	--	--	--	--
rs187753597^1,2		--	72798413(+)	`GCATAA/CGTCCA`	1	--	ds500¹		0	--	--	--	--
rs115218658^1,2	C,F	--	72798414(+)	`CATACG/ATCCAC`	1	--	ds500¹		1		WA	118
rs140946042^1,2	C	--	72798653(+)	`TATGAC/TTCAAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SHQ1 (72798428 - 72911065 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for SHQ1: About this table

Variant ID	Type	Subtype	PubMed ID
esv2659217	CNV	Deletion	23128226
nsv3874	CNV	Insertion	18451855
nsv3873	CNV	Loss	18451855
nsv523229	CNV	Loss	19592680

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SHQ1

DNA2.0 Custom Variant and Variant Library Synthesis for SHQ1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613663 OMIM disorders: --

1 disease for SHQ1:
About MalaCards

dyskeratosis congenita

1 disease from the University of Copenhagen DISEASES database for SHQ1:

Dyskeratosis congenita

SHQ1 for disorders About GeneDecksing

Export disorders for SHQ1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SHQ1 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with SHQ1)

Utopia: connect your pdf to the dynamic
world of online information

SHQ1 is required prior to NAF1 for assembly of H/ACA small nucleolar and telomerase RNPs. (PubMed id 19383767)^{1, 2} Grozdanov P.N.... Meier U.T. (RNA 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs. (PubMed id 21931644)¹ Nallar S.C....Kalvakolanu D.V. (PLoS ONE 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. (PubMed id 22085966)¹ Walbott H....Leulliot N. (amp 2011)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (EMBO J. 2009)
Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (Cell 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55164	HGNC: 25543	AceView: FLJ10539	Ensembl:ENSG00000144736	euGenes: HUgn55164
ECgene: SHQ1	H-InvDB: SHQ1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SHQ1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SHQ1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SHQ1 gene:
Search GeneIP for patents involving SHQ1

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Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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