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SHQ1 Gene

protein-coding   GIFtS: 50
GCID: GC03M072798

SHQ1, H/ACA Ribonucleoprotein Assembly Factor

(Previous name: SHQ1 homolog (S. cerevisiae))
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Aliases
for SHQ1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SHQ1, H/ACA Ribonucleoprotein Assembly Factor1 2
SHQ1 Homolog (S. Cerevisiae)1
Shq1p2
Protein SHQ1 Homolog2
SHQ1 Homolog2

External Ids:    HGNC: 255431   Entrez Gene: 551642   Ensembl: ENSG000001447367   OMIM: 6136635   UniProtKB: Q6PI263   

Export aliases for SHQ1 gene to outside databases

Previous GC identifer: GC03M072883


Summaries
for SHQ1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SHQ1 Gene:
SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs,
modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et
al., 2009 (PubMed 19383767)).(supplied by OMIM, Dec 2010)

GeneCards Summary for SHQ1 Gene:
SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor) is a protein-coding gene.

UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26
Function: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase,
probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10,
NHP2, and NAF1 at the nascent H/ACA RNA




Genomic Views
for SHQ1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHQ1 gene promoter:
         Nkx3-1   Nkx2-2   GCNF   Nkx3-1 v1   CREB   Nkx3-1 v2   deltaCREB   GCNF-1   Nkx3-1 v3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHQ1 promoter sequence
   Search Chromatin IP Primers for SHQ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHQ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p13   Ensembl cytogenetic band:  3p13   HGNC cytogenetic band: 3p13

SHQ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHQ1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M072798:  view genomic region     (about GC identifiers)

Start:
 72,798,428 bp from pter      End:
 72,911,065 bp from pter
Size:
 112,638 bases      Orientation:
 minus strand

Proteins
for SHQ1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26 (See protein sequence)
Recommended Name: Protein SHQ1 homolog  
Size: 577 amino acids; 65125 Da
Subunit: Directly interacts with DKC1 alone, but not in the context of the core trimer composed of DKC1, NOP10 and
NHP2, nor in the presence of NAF1. Does not interact with NAF1
Sequence caution: Sequence=BAA91669.1; Type=Frameshift; Positions=79; Sequence=BAB14947.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6MZJ4 Q7Z748 Q9H7E5 Q9NVS8

Explore the universe of human proteins at neXtProt for SHQ1: NX_Q6PI26

Explore proteomics data for SHQ1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See SHQ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060600.2  
    ENSEMBL proteins: 
     ENSP00000402447   ENSP00000315182   ENSP00000417452   ENSP00000418398   ENSP00000417739  

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    Novus Biologicals SHQ1 Protein
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    Cloud-Clone Corp. Proteins for SHQ1

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         		antibodies-online proteins for SHQ1 (3 products) 

         		antibodies-online peptides for SHQ1

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    antibodies-online kits for SHQ1 (6 products) 

    Domains /
    Families
    for SHQ1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 3 InterPro protein domains:
     IPR007009 SHQ1
     IPR008978 HSP20-like_chaperone
     IPR007052 CS_dom

    Graphical View of Domain Structure for InterPro Entry Q6PI26

    ProtoNet protein and cluster: Q6PI26

    UniProtKB/Swiss-Prot: SHQ1_HUMAN, Q6PI26
    Similarity: Belongs to the SHQ1 family
    Similarity: Contains 1 CS domain


    Find genes that share domains with SHQ1           About GenesLikeMe


    Function
    for SHQ1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHQ1_HUMAN, Q6PI26
    Function: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase,
    probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10,
    NHP2, and NAF1 at the nascent H/ACA RNA

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19383767
         
    Find genes that share ontologies with SHQ1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SHQ1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SHQ1

    miRNA
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    hsa-mir-18a-3p (MIRT040815)

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    5 qRT-PCR Assays for microRNAs that regulate SHQ1:
    hsa-miR-548m hsa-miR-875-3p hsa-miR-4261 hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: SHQ1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Localization
    for SHQ1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SHQ1_HUMAN, Q6PI26: Cytoplasm, cytosol. Nucleus, nucleoplasm. Note=May at least partially shuttle between
    cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal
    bodies. Absent from most H/ACA-box RNA transcription sites
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA19383767
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with SHQ1           About GenesLikeMe


    Pathways & Interactions
    for SHQ1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHQ1
    Interactions:

        Search GeneGlobe Interaction Network for SHQ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SHQ1 (Q6PI263 ENSP000003151824) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    DKC1O608323, ENSP000003585634I2D: score=1 STRING: ENSP00000358563
    MRTO4Q9UKD23, ENSP000003643204I2D: score=1 STRING: ENSP00000364320
    NHP2Q9NX243, ENSP000002746064I2D: score=1 STRING: ENSP00000274606
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022618ribonucleoprotein complex assembly IDA19383767
    GO:0043065positive regulation of apoptotic process IDA--
    GO:2000233negative regulation of rRNA processing IDA--

    Find genes that share ontologies with SHQ1           About GenesLikeMe



    Drugs & Compounds
    for SHQ1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHQ1



    Transcripts
    for SHQ1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SHQ1 gene: 
    NM_018130.2  

    Unigene Cluster for SHQ1:

    SHQ1, H/ACA ribonucleoprotein assembly factor
    Hs.606584  [show with all ESTs]
    Unigene Representative Sequence: BX641074
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468371 ENST00000444040 ENST00000325599(uc003dpf.3 uc010hod.3)
    ENST00000463369 ENST00000475558 ENST00000468347 ENST00000482785 ENST00000471526

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SHQ1:
    hsa-miR-548m hsa-miR-875-3p hsa-miR-4261 hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: SHQ1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHQ1
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHQ1
      QuantiTect SYBR Green Assays in human, mouse, rat SHQ1
      QuantiFast Probe-based Assays in human, mouse, rat SHQ1

    Additional mRNA sequence: 

    AK001401.1 AK092962.1 AK296789.1 BC017204.2 BC017274.2 BC025270.1 BC032671.1 BC039830.1 
    BC047879.2 BX641074.1 

    9 DOTS entries:

    DT.91718956  DT.445698  DT.100779511  DT.95117942  DT.100841575  DT.208923  DT.91753157  DT.91850035 
    DT.97841561 

    Selected AceView cDNA sequences (see all 114):

    AI476821 BM771281 BX370096 BX393619 AK092962 BC017204 BU161478 AL557000 
    AW070280 BC017274 AU117970 BX281969 AI151469 AW664464 BC039830 CR602146 
    BM786501 BG392630 CB216026 BM771386 BX645375 BC047879 AI570146 BC032671 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SHQ1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                     -               
    SP2:                                                                          -               
    SP3:                    -     -                                                               
    SP4:                                                                                          


    ECgene alternative splicing isoforms for SHQ1

    Expression
    for SHQ1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SHQ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCACGAGT
    SHQ1 Expression
    About this image

    SHQ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SHQ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.606584
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    Orthologs
    for SHQ1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SHQ1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Shq11 , 5 SHQ1 homolog (S. cerevisiae)1, 5 79.11(n)1
    77.02(a)1    		   6 (46.82 cM)5
    721711  NM_181590.41  NP_853621.21 
     1005730815 
    chicken
    (Gallus gallus)    		 Aves SHQ11 SHQ1 homolog (S. cerevisiae) 67.67(n)
    63.78(a)    		   416096  XM_004944692.1  XP_004944749.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SHQ16
    		 SHQ1, H/ACA ribonucleoprotein assembly factor
    		 54(a)
    		 1 ↔ 1
    		 2(179314553-179433668)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia shq11 SHQ1, H/ACA ribonucleoprotein assembly factor 60.52(n)
    58.21(a)    		   780072  NM_001079148.1  NP_001072616.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii shq11 SHQ1 homolog (S. cerevisiae) 62.18(n)
    61.35(a)    		   567601  NM_001080600.1  NP_001074069.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG100556
    		 --
    		 21(a)
    		 1 ↔ 1
    		 3R(3009823-3012375)
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y48A5A.11 CELE_Y48A5A.1 47.08(n)
    38.9(a)    		   176997  NM_067749.3  NP_500150.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SHQ1(YIL104C)4
    SHQ11    		 Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones less4
    SHQ11    		 46.02(n)1
    30.71(a)1    		   9(171505-169982)4
    8547021, 4  NP_012162.31  NP_012162.14 


    ENSEMBL Gene Tree for SHQ1 (if available)
    TreeFam Gene Tree for SHQ1 (if available)

    Paralogs
    for SHQ1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHQ1 gene

    Find genes that share paralogs with SHQ1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SHQ1
    PGOHUM00000238489


    Genomic Variants
    for SHQ1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SHQ1 (see all 2060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1429777451,2
    		C--72798040(+) GGGTGA/TGGCTG 1 -- ds50010--------
    rs1875083051,2
    		C--72798101(+) ACCCTA/GTCTCA 1 -- ds50010--------
    rs1923328451,2
    		C--72798116(+) CACACA/GCACAC 1 -- ds50010--------
    rs340023441,2
    		C--72798122(+) ACACG-/CACACAC 1 -- ds50010--------
    rs3691027951,2
    		C--72798123(+) CACAC-/CAACACA 1 -- ds50010--------
    rs2020409231,2
    		--72798148(+) CACAC-/ACAG  
                GCAGA     		1 -- ds50010--------
    rs1855586411,2
    		--72798358(+) ACCTAA/CCATAT 1 -- ds50010--------
    rs1877535971,2
    		--72798413(+) GCATAA/CGTCCA 1 -- ds50010--------
    rs1152186581,2
    		C,F--72798414(+) CATACG/ATCCAC 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1409460421,2
    		C--72798653(+) TATGAC/TTCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SHQ1 (72798428 - 72911065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SHQ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659217CNV Deletion23128226
    nsv3874CNV Insertion18451855
    nsv3873CNV Loss18451855
    nsv523229CNV Loss19592680

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    Disorders / Diseases
    for SHQ1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 613663    OMIM disorders: --

    1 inferred disease relationship from the University of Copenhagen DISEASES database for SHQ1:
    Dyskeratosis congenita

    Find genes that share disorders with SHQ1           About GenesLikeMe


    Export disorders for SHQ1 gene to outside databases

    Publications
    for SHQ1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHQ1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SHQ1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. SHQ1 is required prior to NAF1 for assembly of H/ACA small nucleolar and telomerase RNPs. (PubMed id 19383767)1, 2 Grozdanov P.N.... Meier U.T. (RNA 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs. (PubMed id 21931644)1 Nallar S.C....Kalvakolanu D.V. (PLoS ONE 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. (PubMed id 22085966)1 Walbott H....Leulliot N. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

    External Searches for SHQ1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SHQ1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55164 HGNC: 25543 AceView: FLJ10539 Ensembl:ENSG00000144736 euGenes: HUgn55164
    ECgene: SHQ1 H-InvDB: SHQ1

    Other Databases showing SHQ1 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing SHQ1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SHQ1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHQ1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SHQ1 gene:
    Search GeneIP for patents involving SHQ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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