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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHPRH Gene

protein-coding   GIFtS: 54
GCID: GC06M146185

SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein...

(Previous name: SNF2 histone linker PHD RING helicase)
  Search for SHPRH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase SHPRH2
SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase2 3     EC 3.6.4.-3
SNF2 Histone Linker PHD RING Helicase1     EC 6.3.2.-3
2610103K11Rik2     KIAA20233
bA545I5.22     

External Ids:    HGNC: 193361   Entrez Gene: 2572182   Ensembl: ENSG000001464147   OMIM: 6080485   UniProtKB: Q149N83   

Export aliases for SHPRH gene to outside databases

Previous GC identifers: GC00U902638 GC06M146120 GC06M146186 GC06M146236 GC06M143769


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHPRH Gene:
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins,
transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006
(PubMed 17108083)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SHPRH Gene: 
SHPRH (SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include helicase activity and ligase activity.

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the
UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,
promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Gene Wiki entry for SHPRH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHPRH gene promoter:
         HOXA9B   HOXA9   Max   S8   CUTL1   MRF-2   Meis-1b   Meis-1   c-Myc   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHPRH promoter sequence
   Search SABiosciences Chromatin IP Primers for SHPRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHPRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24.2

SHPRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHPRH gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M146185:  view genomic region     (about GC identifiers)

Start:
146,185,381 bp from pter      End:
146,285,559 bp from pter
Size:
100,179 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase SHPRH  
Size: 1683 amino acids; 193079 Da
Subunit: Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18
Sequence caution: Sequence=AAI13090.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=AAI17686.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC04459.1; Type=Erroneous
initiation; Sequence=BAC23119.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=CAH18145.1;
Type=Frameshift; Positions=762, 997;
Secondary accessions: Q149N9 Q5VV79 Q68DS5 Q7Z5J5 Q8IVE8 Q8IWQ9 Q8N1S8 Q8NBR7
Alternative splicing: 4 isoforms:  Q149N8-1   Q149N8-2   Q149N8-4   Q149N8-5   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SHPRH: NX_Q149N8

Explore proteomics data for SHPRH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q149N8

  • SHPRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHPRH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001036148.2  NP_775105.1  

    ENSEMBL proteins: 
     ENSP00000403790   ENSP00000356475   ENSP00000412797   ENSP00000275233   ENSP00000408019  
     ENSP00000430528   ENSP00000429548   ENSP00000356473  

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    Cloud-Clone Corp. Proteins for SHPRH 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    SHPRH for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/12 InterPro protein domains (see all 12):
     IPR011991 WHTH_DNA-bd_dom
     IPR017907 Znf_RING_CS
     IPR019786 Zinc_finger_PHD-type_CS
     IPR001841 Znf_RING
     IPR001965 Znf_PHD

    Graphical View of Domain Structure for InterPro Entry Q149N8

    ProtoNet protein and cluster: Q149N8

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB001965 Zn-finger-like
    IPB005818 Histone H1/H5


    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Domain: The RING finger mediates E3 ubiquitin ligase activity
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    SHPRH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHPRH_HUMAN, Q149N8
    Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the
    UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,
    promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 3.6.4.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    SHPRH for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidSHPRH 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHPRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for SHPRH (Q149N82, 3 ENSP000003564734) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372682, 3, ENSP000002205844MINT-64543 I2D: score=4 STRING: ENSP00000220584
    LPPQ930522, 3MINT-64544 I2D: score=3 
    FBXW7Q969H02, 3, ENSP000002817084MINT-64545 I2D: score=4 STRING: ENSP00000281708
    USP36Q9P2753, ENSP000003105904I2D: score=2 STRING: ENSP00000310590
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006334nucleosome assembly IEA--
    GO:0016567protein ubiquitination IEA--

    SHPRH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHPRH

    Search CenterWatch for drugs/clinical trials and news about SHPRH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHPRH gene (2 alternative transcripts): 
    NM_001042683.2  NM_173082.3  

    Unigene Cluster for SHPRH:

    SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
    Hs.723297  [show with all ESTs]
    Unigene Representative Sequence: NM_001042683
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417762 ENST00000367505 ENST00000438092 ENST00000275233 ENST00000433355(uc003qlg.1)
    ENST00000519632(uc003qlh.3 uc003qlj.1) ENST00000523276(uc003qli.1)
    ENST00000520752 ENST00000521977 ENST00000367503(uc003qlf.3 uc003qle.3)

    miRNA
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    hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-501-3p hsa-miR-3692 hsa-miR-502-3p hsa-miR-548a-3p hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidSHPRH 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK075318.1 AK094944.1 AK123205.1 AK126959.1 AK130768.1 AL833521.1 AY161136.1 AY163808.1 
    BC113089.1 BC117685.1 BC117686.1 BX648322.1 CR749290.1 

    10 DOTS entries:

    DT.100744778  DT.310697  DT.95090077  DT.100744777  DT.40203362  DT.95253200  DT.101966069  DT.70103496 
    DT.209490  DT.100717785 

    24/107 AceView cDNA sequences (see all 107):

    AK126959 CR615021 BF476033 AI148338 AY163808 BX113386 BQ014853 AB095943 
    AV704509 AI224908 AL833521 AI888407 AI631201 AA255426 BU072582 AA333210 
    BX362621 AA443760 BM931244 C04062 AA476814 AK094944 AI682169 AK130768 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SHPRH    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                    -           -                           
    SP3:                                                                                                                                                            
    SP4:              -     -                                                                                                                                       
    SP5:              -     -                                                                                                                                       

    ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
    SP1:  -                             -                                               -               
    SP2:                                -                                                               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SHPRH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHPRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATAATTT
    SHPRH Expression
    About this image


    See SHPRH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHPRH

    SOURCE GeneReport for Unigene cluster: Hs.723297

    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Tissue specificity: Broadly expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including SHPRH: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SHPRH gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shprh1 , 5 SNF2 histone linker PHD RING helicase1, 5 85.62(n)1
    86.54(a)1
      10 (3.66 cM)5
    2682811  NM_001077707.11  NP_001071175.11 
     111494275 
    chicken
    (Gallus gallus)
    Aves SHPRH1 SNF2 histone linker PHD RING helicase 72.67(n)
    72.73(a)
      421613  XM_419651.3  XP_419651.3 
    lizard
    (Anolis carolinensis)
    Reptilia SHPRH6
    SNF2 histone linker PHD RING helicase, E3 ubiquiti...
    70(a)
    1 ↔ 1
    1(207133276-207185823)
    zebrafish
    (Danio rerio)
    Actinopterygii shprh1 SNF2 histone linker PHD RING helicase 63.63(n)
    64.93(a)
      560526  XM_003200310.1  XP_003200358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73761 CG7376 44.98(n)
    34.28(a)
      38715  NM_139777.1  NP_648034.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IRC20(YLR247C)4 Putative helicase; localizes to the mitochondrion and more   --   12(633354-628684) 850949  NP_013348.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G407701 RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing more 47.83(n)
    38.54(a)
      818674  NM_129640.5  NP_181609.4 


    ENSEMBL Gene Tree for SHPRH (if available)
    TreeFam Gene Tree for SHPRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHPRH gene
    5 SIMAP similar genes for SHPRH using alignment to 5 protein entries:     SHPRH_HUMAN (see all proteins):
    ERCC6L    BTAF1    CHD4    CHD5    ATRX

    SHPRH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1524 SNPs in SHPRH are shown (see all 1524)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0318584
    A melanoma cell line4--see VAR_0318582 S F mis40--------
    VAR_0318574
    An ovarian cancer cell line4--see VAR_0318572 Q R mis40--------
    VAR_0318594
    A melanoma cell line4--see VAR_0318592 N Y mis40--------
    VAR_0647504
    ----see VAR_0647502 V D mis40--------
    rs1447648581,2
    C--146208258(+) AACAAC/TTCATA 2 -- int10--------
    rs729999141,2
    C,F--146208401(+) ATCAAT/AGGAAG 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1485577401,2
    --146208434(+) TTCTTG/TGCTAT 2 -- int10--------
    rs1869339401,2
    --146208518(+) AAAGAC/TTTATG 2 -- int10--------
    rs1913980381,2
    C--146208576(+) TATGAG/TTCCAG 2 -- int10--------
    rs1857518941,2
    C--146208606(+) AGACTA/GGTTTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SHPRH (146185381 - 146285559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SHPRH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830835CNV Loss17160897
    nsv437525CNV Loss16327808

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SHPRH for disorders           About MalaCards
    OMIM gene information: 608048    OMIM disorders: --


    SHPRH for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHPRH
    Human Genome Epidemiology (HuGE) Navigator: SHPRH (1 document)

    Export disorders for SHPRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHPRH gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SHPRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. (PubMed id 12837266)1, 2, 3, 9 Sood R.... Trent J.M. (2003)
    2. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PubMed id 17108083)1, 2, 9 Unk I.... Haracska L. (2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)1, 2 Motegi A.... Myung K. (2008)
    5. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. (PubMed id 17130289)1, 2 Motegi A.... Myung K. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to m odulate post replication repair and cell survival. (PubMed id 23555860)1 Sertic S....Rotondo G. (2013)
    8. Human CCAAT/enhancer-binding protein b interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)1 Steinberg X.P....Gutierrez J.L. (2012)
    9. SHPRH and HLTF act in a damage-specific manner to coo rdinate different forms of postreplication repair and prevent mutagenesis. (PubMed id 21396873)1 Lin J.R....Cimprich K.A. (2011)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 257218 HGNC: 19336 AceView: SHPRH Ensembl:ENSG00000146414 euGenes: HUgn257218
    ECgene: SHPRH H-InvDB: SHPRH

    (According to HUGE)
    About This Section
    HUGE: KIAA2023

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHPRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHPRH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHPRH gene:
    Search GeneIP for patents involving SHPRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in SHPRH promoter
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