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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SHPRH Gene

protein-coding GIFtS: 53
GCID: GC06M146185

SNF2 histone linker PHD RING helicase, E3 ubiquitin protein...

(Previous name: SNF2 histone linker PHD RING helicase )

Search for SHPRH
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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase¹ ²		SNF2 Histone Linker PHD RING Helicase¹
BA545I5.2¹		2610103K11Rik²
KIAA2023¹ ³		E3 Ubiquitin-Protein Ligase SHPRH²
SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase² ³		EC 3.6.4.-³
FLJ90837¹		EC 6.3.2.-³

External Ids:	HGNC: 19336¹	Entrez Gene: 257218²	Ensembl: ENSG00000146414⁷	OMIM: 608048⁵	UniProtKB: Q149N8³

Export aliases for SHPRH gene to outside databases

Previous GC identifers: GC00U902638 GC06M146120 GC06M146186 GC06M146236 GC06M143769

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHPRH:

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins,

transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 (PubMed

17108083)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8

Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the

UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,

promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Gene Wiki entry for SHPRH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SHPRH gene promoter:
HOXA9B HOXA9 Max S8 CUTL1 MRF-2 Meis-1b Meis-1 c-Myc Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHPRH promoter sequence

Search SABiosciences Chromatin IP Primers for SHPRH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHPRH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24.2

SHPRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHPRH gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M146185: view genomic region (about GC identifiers)

Start:	146,185,381 bp from pter	End:	146,285,559 bp from pter
Size:	100,179 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase SHPRH

Size: 1683 amino acids; 193079 Da

Subunit: Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18

Sequence caution: Sequence=AAI13090.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=AAI17686.1;

Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC04459.1; Type=Erroneous initiation;

Sequence=BAC23119.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=CAH18145.1; Type=Frameshift;

Positions=762, 997;

Secondary accessions: Q149N9 Q5VV79 Q68DS5 Q7Z5J5 Q8IVE8 Q8IWQ9 Q8N1S8 Q8NBR7

Alternative splicing: 4 isoforms: Q149N8-1 Q149N8-2 Q149N8-4 Q149N8-5 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SHPRH: NX_Q149N8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q149N8

SHPRH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001036148.2 NP_775105.1

ENSEMBL proteins:

ENSP00000403790 ENSP00000356475 ENSP00000412797 ENSP00000275233 ENSP00000408019

ENSP00000430528 ENSP00000429548 ENSP00000356473

Human Recombinant Protein Products for SHPRH:

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	Novus Biologicals SHPRH Protein Novus Biologicals SHPRH Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SHPRH

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	IEA	--
GO:0005634	nucleus	IEA	--

SHPRH for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SHPRH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SHPRH for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR017907 Znf_RING_CS

IPR019786 Zinc_finger_PHD-type_CS

IPR001841 Znf_RING

IPR001965 Znf_PHD

Graphical View of Domain Structure for InterPro Entry Q149N8

ProtoNet protein and cluster: Q149N8

3 Blocks protein families:

IPB000330 SNF2 related domain

IPB001965 Zn-finger-like

IPB005818 Histone H1/H5

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8

Domain: The RING finger mediates E3 ubiquitin ligase activity

Similarity: Belongs to the SNF2/RAD54 helicase family

Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SHPRH_HUMAN, Q149N8

Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the

UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,

promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 3.6.4.-¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

SHPRH for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SHPRH

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SHPRH Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHPRH
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SHPRH (see all 19):
		hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-501-3p hsa-miR-3692 hsa-miR-502-3p hsa-miR-548a-3p hsa-miR-3122

		SwitchGear 3'UTR luciferase reporter plasmid: SHPRH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHPRH (see all 7) OriGene shRNA RFP: SHPRH OriGene siRNA: SHPRH
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHPRH

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8

Pathway: Protein modification; protein ubiquitination

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SHPRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/14 Interacting proteins for SHPRH (Q149N8^{2, 3} ENSP00000356473⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FDFT1	P37268²^,³, ENSP00000220584⁴	MINT-64543 I2D: score=4 STRING: ENSP00000220584
LPP	Q93052²^,³	MINT-64544 I2D: score=3
FBXW7	Q969H0²^,³, ENSP00000281708⁴	MINT-64545 I2D: score=4 STRING: ENSP00000281708
USP36	Q9P275³, ENSP00000310590⁴	I2D: score=2 STRING: ENSP00000310590
USP49	Q70CQ1³, ENSP00000297229⁴	I2D: score=2 STRING: ENSP00000297229

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006334	nucleosome assembly	IEA	--
GO:0016567	protein ubiquitination	IEA	--

SHPRH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SHPRH
Search CenterWatch for drugs/clinical trials and news about SHPRH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SHPRH gene (2 alternative transcripts):

NM_001042683.2 NM_173082.3

Unigene Cluster for SHPRH:

SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase

Hs.723297 [show with all ESTs]

Unigene Representative Sequence: NM_001042683

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000417762 ENST00000367505 ENST00000438092 ENST00000275233 ENST00000433355(uc003qlg.1)

ENST00000519632(uc003qlh.3 uc003qlj.1) ENST00000523276(uc003qli.1)

ENST00000520752 ENST00000521977 ENST00000367503(uc003qlf.3 uc003qle.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SHPRH Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHPRH
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate SHPRH (see all 19):
		hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-501-3p hsa-miR-3692 hsa-miR-502-3p hsa-miR-548a-3p hsa-miR-3122

		SwitchGear 3'UTR luciferase reporter plasmid: SHPRH 3' UTR sequence

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Additional cDNA sequence:

AK075318.1 AK094944.1 AK123205.1 AK126959.1 AK130768.1 AL833521.1 AY161136.1 AY163808.1

BC113089.1 BC117685.1 BC117686.1 BX648322.1 CR749290.1

10 DOTS entries:

DT.310697 DT.100744778 DT.95090077 DT.40203362 DT.95253200 DT.100744777 DT.101966069 DT.70103496

DT.209490 DT.100717785

24/107 AceView cDNA sequences (see all 107):

AA315737 AI479552 AL833521 BF476033 BU072582 AK130768 NM_173082 AA602111

AY163808 BX504969 AA443760 AI682169 BX113386 AV704509 AA476814 AK094944

AI224908 BM931244 CA390223 BQ014853 AA333210 CR615021 AB095943 AK126959

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SHPRH About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^
SP1:																																											-
SP2:																																							-				-
SP3:
SP4:					-		-
SP5:					-		-

ExUns:	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	·	32c
SP1:	-										-																-
SP2:											-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SHPRH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SHPRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTATAATTT

About this image
See SHPRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHPRH

SOURCE GeneReport for Unigene cluster: Hs.723297

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8

Tissue specificity: Broadly expressed

SABiosciences Expression via Pathway-Focused PCR Arrays including SHPRH:

Epigenetic Chromatin Remodeling Factors in human mouse rat

Ubiquitin Ligases in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SHPRH gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SHPRH¹	SNF2 histone linker PHD RING helicase	72.67(n) 72.73(a)		421613 XM_419651.3 XP_419651.3
lizard (Anolis carolinensis)	Reptilia	SHPRH⁶	--	70(a)	1 ↔ 1	1(207136154-207182355)
zebrafish (Danio rerio)	Actinopterygii	shprh¹	SNF2 histone linker PHD RING helicase	63.63(n) 64.93(a)		560526 XM_003200310.1 XP_003200358.1
fruit fly (Drosophila melanogaster)	Insecta	CG7376¹	CG7376	44.98(n) 34.28(a)		38715 NM_139777.1 NP_648034.1
worm (Caenorhabditis elegans)	Secernentea	T05A12.4⁶	Protein T05A12.4, isoform b	10(a)	1 ↔ 1	IV(6887937-6897766)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G40770¹	RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing more	47.83(n) 38.54(a)		818674 NM_129640.5 NP_181609.4
rice (Oryza sativa)	Liliopsida	--	helicase conserved C-terminal domain containing pr...	27(a)	1 ↔ 1	7(28831622-28833733)

ENSEMBL Gene Tree for SHPRH (if available)
TreeFam Gene Tree for SHPRH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SHPRH gene

TTF2² HLTF²

5 SIMAP similar genes for SHPRH using alignment to 5 protein entries: SHPRH_HUMAN (see all proteins):

ERCC6L BTAF1 CHD4 CHD5 ATRX

SHPRH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145018869^1,2		--	146205450(+)	`AACATA/GGCAGA`	5	--	int¹ nc-transcript-variant		0	--	--	--	--
rs1133832^1,2	C,F,O,A,H	--	146205604(+)	`CTGGGA/GCTACT`	5	--	nc-transcript-variantint¹		33		MN NA NS EA WA CSA	3100
rs189627545^1,2		--	146205671(+)	`TAAGAA/TCAACT`	5	--	int¹ nc-transcript-variant		0	--	--	--	--
rs148157082^1,2		--	146205678(+)	`AACTA-/CTTCTAAA`	5	--	int¹ nc-transcript-variant		0	--	--	--	--
rs2252330^1,2	C,F,O,H	--	146205780(+)	`TTGTAT/CTTGTT`	5	--	int¹ nc-transcript-variant		15		NA WA CSA EA	516
rs76094582^1,2	C,F	--	146205794(+)	`AACAAT/CTGGAA`	5	--	nc-transcript-variantint¹		1		WA	118
rs183405006^1,2		--	146205874(+)	`TGATAC/TCTTTT`	5	--	int¹ nc-transcript-variant		0	--	--	--	--
rs138740022^1,2		--	146205906(+)	`ACCCCA/GTATGT`	5	--	int¹ nc-transcript-variant		0	--	--	--	--
rs11760^1,2	C,F,A,H	--	146205973(-)	`ATATCC/AATTAA`	5	--	nc-transcript-variantut3¹		14		MN NA WA CSA EA	878
rs11232^1,2	C,F	--	146206001(-)	`AAAAAC/TTGTTT`	5	--	ut3¹ nc-transcript-variant		7		MN NA CSA	450

HapMap Linkage Disequilibrium report for SHPRH (146185381 - 146285559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SHPRH
1 CNV: 1140

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SHPRH for disorders About MalaCards

SHPRH for disorders About GeneDecksing

OMIM gene information: 608048 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: SHPRH (1 document)

Export disorders for SHPRH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SHPRH gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with SHPRH)

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Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. (PubMed id 12837266)^{1, 2, 3, 9} Sood R.... Trent J.M. (2003)
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PubMed id 17108083)^{1, 2, 9} Unk I.... Haracska L. (2006)
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)^{1, 2} Motegi A.... Myung K. (2008)
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. (PubMed id 17130289)^{1, 2} Motegi A.... Myung K. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human CCAAT/enhancer-binding protein b interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)¹ Steinberg X.P....Gutierrez J.L. (2012)
SHPRH and HLTF act in a damage-specific manner to coo rdinate different forms of postreplication repair and prevent mutagenesis. (PubMed id 21396873)¹ Lin J.R....Cimprich K.A. (2011)
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)² Varela I....Futreal P.A. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 257218	HGNC: 19336	AceView: SHPRH	Ensembl:ENSG00000146414	euGenes: HUgn257218
ECgene: SHPRH	H-InvDB: SHPRH

(According to HUGE)
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HUGE: KIAA2023

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SHPRH	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SHPRH	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SHPRH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SHPRH gene:
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GeneCards and IP:
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