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Aliases for SHPRH Gene

Aliases for SHPRH Gene

  • SNF2 Histone Linker PHD RING Helicase 2 3
  • SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase 2 3 5
  • SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase 3 4
  • 2610103K11Rik 3
  • EC 3.6.4.- 4
  • EC 6.3.2.- 4
  • BA545I5.2 3
  • KIAA2023 4

External Ids for SHPRH Gene

Previous GeneCards Identifiers for SHPRH Gene

  • GC00U902638
  • GC06M146120
  • GC06M146186
  • GC06M146236
  • GC06M143769
  • GC06M146185

Summaries for SHPRH Gene

Entrez Gene Summary for SHPRH Gene

  • SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SHPRH Gene

SHPRH (SNF2 Histone Linker PHD RING Helicase) is a Protein Coding gene. GO annotations related to this gene include ligase activity and helicase activity.

UniProtKB/Swiss-Prot for SHPRH Gene

  • E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to Lys-164 of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through Lys-63.

Gene Wiki entry for SHPRH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHPRH Gene

Genomics for SHPRH Gene

Regulatory Elements for SHPRH Gene

Promoters for SHPRH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SHPRH on UCSC Golden Path with GeneCards custom track

Genomic Location for SHPRH Gene

Chromosome:
6
Start:
145,862,721 bp from pter
End:
145,964,423 bp from pter
Size:
101,703 bases
Orientation:
Minus strand

Genomic View for SHPRH Gene

Genes around SHPRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHPRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHPRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHPRH Gene

Proteins for SHPRH Gene

  • Protein details for SHPRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q149N8-SHPRH_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase SHPRH
    Protein Accession:
    Q149N8
    Secondary Accessions:
    • Q149N9
    • Q5VV79
    • Q68DS5
    • Q7Z5J5
    • Q8IVE8
    • Q8IWQ9
    • Q8N1S8
    • Q8NBR7

    Protein attributes for SHPRH Gene

    Size:
    1683 amino acids
    Molecular mass:
    193079 Da
    Quaternary structure:
    • Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18.
    SequenceCaution:
    • Sequence=AAI13090.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAI17686.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC04459.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC23119.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAH18145.1; Type=Frameshift; Positions=762, 997; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SHPRH Gene

    Alternative splice isoforms for SHPRH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHPRH Gene

Proteomics data for SHPRH Gene at MOPED

Post-translational modifications for SHPRH Gene

  • Ubiquitination at Lys 1256, Lys 1562, and Lys 1572
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SHPRH Gene

Domains & Families for SHPRH Gene

Gene Families for SHPRH Gene

Suggested Antigen Peptide Sequences for SHPRH Gene

Graphical View of Domain Structure for InterPro Entry

Q149N8

UniProtKB/Swiss-Prot:

SHPRH_HUMAN :
  • The RING finger mediates E3 ubiquitin ligase activity.
  • Belongs to the SNF2/RAD54 helicase family.
  • Contains 1 PHD-type zinc finger.
Domain:
  • The RING finger mediates E3 ubiquitin ligase activity.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
Similarity:
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with SHPRH: view

Function for SHPRH Gene

Molecular function for SHPRH Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to Lys-164 of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through Lys-63.

Enzyme Numbers (IUBMB) for SHPRH Gene

Gene Ontology (GO) - Molecular Function for SHPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 17108083
GO:0005515 protein binding IEA,IPI 25416956
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with SHPRH: view
genes like me logo Genes that share phenotypes with SHPRH: view

Animal Model Products

miRNA for SHPRH Gene

miRTarBase miRNAs that target SHPRH

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHPRH Gene

Localization for SHPRH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHPRH Gene COMPARTMENTS Subcellular localization image for SHPRH gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SHPRH Gene

Pathways & Interactions for SHPRH Gene

SuperPathways for SHPRH Gene

No Data Available

UniProtKB/Swiss-Prot Q149N8-SHPRH_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SHPRH Gene

Activates:

Gene Ontology (GO) - Biological Process for SHPRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with SHPRH: view

No data available for Pathways by source for SHPRH Gene

Drugs & Compounds for SHPRH Gene

No Compound Related Data Available

Transcripts for SHPRH Gene

Unigene Clusters for SHPRH Gene

SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHPRH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - -

ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
SP1: - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for SHPRH Gene

GeneLoc Exon Structure for
SHPRH
ECgene alternative splicing isoforms for
SHPRH

Expression for SHPRH Gene

mRNA expression in normal human tissues for SHPRH Gene

Protein differential expression in normal tissues from HIPED for SHPRH Gene

This gene is overexpressed in Breast (15.6), Plasma (15.2), Fetal ovary (10.2), Fetal testis (7.5), and Adrenal (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHPRH Gene



SOURCE GeneReport for Unigene cluster for SHPRH Gene Hs.723297

mRNA Expression by UniProt/SwissProt for SHPRH Gene

Q149N8-SHPRH_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expression patterns with SHPRH: view

Protein tissue co-expression partners for SHPRH Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SHPRH Gene

Orthologs for SHPRH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SHPRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHPRH 35
  • 99.56 (n)
  • 99.58 (a)
SHPRH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHPRH 36
  • 90 (a)
OneToOne
SHPRH 35
  • 89.62 (n)
  • 90.78 (a)
dog
(Canis familiaris)
Mammalia SHPRH 35
  • 91.38 (n)
  • 92.75 (a)
SHPRH 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shprh 16
Shprh 36
  • 86 (a)
OneToOne
Shprh 35
  • 85.5 (n)
  • 86.42 (a)
oppossum
(Monodelphis domestica)
Mammalia SHPRH 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SHPRH 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shprh 35
  • 84.43 (n)
  • 85.81 (a)
chicken
(Gallus gallus)
Aves SHPRH 36
  • 72 (a)
OneToOne
SHPRH 35
  • 72.79 (n)
  • 72.85 (a)
lizard
(Anolis carolinensis)
Reptilia SHPRH 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia shprh 35
  • 67.99 (n)
  • 68.62 (a)
zebrafish
(Danio rerio)
Actinopterygii shprh 36
  • 64 (a)
OneToOne
shprh 35
  • 63.63 (n)
  • 64.93 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007417 35
  • 44.72 (n)
  • 35.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7376 36
  • 22 (a)
OneToOne
CG7376 35
  • 45.39 (n)
  • 34.94 (a)
worm
(Caenorhabditis elegans)
Secernentea T05A12.4 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IRC20 36
  • 16 (a)
OneToOne
IRC20 38
Species with no ortholog for SHPRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHPRH Gene

ENSEMBL:
Gene Tree for SHPRH (if available)
TreeFam:
Gene Tree for SHPRH (if available)

Paralogs for SHPRH Gene

(5) SIMAP similar genes for SHPRH Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SHPRH: view

No data available for Paralogs for SHPRH Gene

Variants for SHPRH Gene

Sequence variations from dbSNP and Humsavar for SHPRH Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2244003 -- 145,890,248(+) actag(C/T)tgcct intron-variant
rs2247206 -- 145,895,048(+) CAATA(C/T)AAAGT intron-variant
rs2247211 -- 145,895,243(+) ACATA(A/G)GATCT intron-variant
rs2247317 -- 145,896,434(+) TAATA(C/T)GTTTC intron-variant
rs2247429 -- 145,896,633(+) CTTCC(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHPRH Gene

Variant ID Type Subtype PubMed ID
nsv830835 CNV Loss 17160897
nsv437525 CNV Loss 16327808

Variation tolerance for SHPRH Gene

Residual Variation Intolerance Score: 1.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SHPRH Gene

HapMap Linkage Disequilibrium report
SHPRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHPRH Gene

Disorders for SHPRH Gene

Relevant External Links for SHPRH

Genetic Association Database (GAD)
SHPRH
Human Genome Epidemiology (HuGE) Navigator
SHPRH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SHPRH

No disorders were found for SHPRH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHPRH Gene

Publications for SHPRH Gene

  1. Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. (PMID: 12837266) Sood R. … Trent J.M. (Genomics 2003) 2 3 4 23 67
  2. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PMID: 17108083) Unk I. … Haracska L. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. (PMID: 25023518) Zeman M.K. … Cimprich K.A. (J. Cell Biol. 2014) 3

Products for SHPRH Gene

Sources for SHPRH Gene

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