Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SHPRH Gene

protein-coding   GIFtS: 53
GCID: GC06M146185

SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein...

(Previous name: SNF2 histone linker PHD RING helicase)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase SHPRH2
SNF2, Histone-Linker, PHD And RING Finger Domain-Containing Helicase2 3     EC 3.6.4.-3
SNF2 Histone Linker PHD RING Helicase1     EC 6.3.2.-3
2610103K11Rik2     KIAA20233
bA545I5.22     

External Ids:    HGNC: 193361   Entrez Gene: 2572182   Ensembl: ENSG000001464147   OMIM: 6080485   UniProtKB: Q149N83   

Export aliases for SHPRH gene to outside databases

Previous GC identifers: GC00U902638 GC06M146120 GC06M146186 GC06M146236 GC06M143769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SHPRH Gene:
SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins,
transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006
(PubMed 17108083)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SHPRH Gene:
SHPRH (SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include helicase activity and ligase activity.

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the
UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,
promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

Gene Wiki entry for SHPRH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the SHPRH gene promoter:
         HOXA9B   HOXA9   Max   S8   CUTL1   MRF-2   Meis-1b   Meis-1   c-Myc   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHPRH promoter sequence
   Search Chromatin IP Primers for SHPRH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHPRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24.2

SHPRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHPRH gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M146185:  view genomic region     (about GC identifiers)

Start:
146,185,381 bp from pter      End:
146,285,559 bp from pter
Size:
100,179 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase SHPRH  
Size: 1683 amino acids; 193079 Da
Subunit: Homodimer. Interacts with HLTF, PCNA, UBE2N and RAD18
Sequence caution: Sequence=AAI13090.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=AAI17686.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC04459.1; Type=Erroneous
initiation; Sequence=BAC23119.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=CAH18145.1;
Type=Frameshift; Positions=762, 997;
1 PDB 3D structure from and Proteopedia for SHPRH:
2M85 (3D)    
Secondary accessions: Q149N9 Q5VV79 Q68DS5 Q7Z5J5 Q8IVE8 Q8IWQ9 Q8N1S8 Q8NBR7
Alternative splicing: 4 isoforms:  Q149N8-1   Q149N8-2   Q149N8-4   Q149N8-5   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for SHPRH: NX_Q149N8

Explore proteomics data for SHPRH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1256, Lys1562, Lys1572
  • Modification sites at PhosphoSitePlus

  • See SHPRH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036148.2  NP_775105.1  

    ENSEMBL proteins: 
     ENSP00000403790   ENSP00000356475   ENSP00000412797   ENSP00000275233   ENSP00000408019  
     ENSP00000430528   ENSP00000429548   ENSP00000356473  

    SHPRH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SHPRH
    GenScript Custom Purified and Recombinant Proteins Services for SHPRH
    Novus Biologicals SHPRH Protein
    Novus Biologicals SHPRH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHPRH

     
    Search eBioscience for Proteins for SHPRH 

    SHPRH Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SHPRH
    OriGene Custom Antibody Services for SHPRH
    Novus Biologicals SHPRH Antibodies
    Abcam antibodies for SHPRH
    Cloud-Clone Corp. Antibodies for SHPRH
    Search ThermoFisher Antibodies for SHPRH
    LSBio Antibodies in human, mouse, rat for SHPRH

    SHPRH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SHPRH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SHPRH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SHPRH
    Cloud-Clone Corp. CLIAs for SHPRH
    Search eBioscience for ELISAs for SHPRH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 12):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR000330 SNF2_N
     IPR013083 Znf_RING/FYVE/PHD
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q149N8

    ProtoNet protein and cluster: Q149N8

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB001965 Zn-finger-like
    IPB005818 Histone H1/H5


    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Domain: The RING finger mediates E3 ubiquitin ligase activity
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with SHPRH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHPRH_HUMAN, Q149N8
    Function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the
    UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18,
    promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 3.6.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SHPRH           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHPRH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHPRH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SHPRH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHPRH

    miRNA
    Products:
        
    miRTarBase miRNAs that target SHPRH:
    hsa-mir-92a-3p (MIRT049497)

    Block miRNA regulation of human, mouse, rat SHPRH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHPRH (see all 19):
    hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-501-3p hsa-miR-3692 hsa-miR-502-3p hsa-miR-548a-3p hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidSHPRH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SHPRH
    Predesigned siRNA for gene silencing in human, mouse, rat SHPRH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SHPRH

    Clone
    Products:
         
    OriGene clones in human, mouse for SHPRH (see all 12)
    OriGene ORF clones in mouse, rat for SHPRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SHPRH (NM_173082)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHPRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHPRH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SHPRH
    Browse ESI BIO Cell Lines and PureStem Progenitors for SHPRH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHPRH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SHPRH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SHPRH: 

              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SHPRH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHPRH (Q149N82, 3 ENSP000003564734) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDFT1P372682, 3, ENSP000002205844MINT-64543 I2D: score=4 STRING: ENSP00000220584
    LPPQ930522, 3MINT-64544 I2D: score=3 
    FBXW7Q969H02, 3, ENSP000002817084MINT-64545 I2D: score=4 STRING: ENSP00000281708
    USP36Q9P2753, ENSP000003105904I2D: score=2 STRING: ENSP00000310590
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006334nucleosome assembly IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with SHPRH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHPRH



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SHPRH gene (2 alternative transcripts): 
    NM_001042683.2  NM_173082.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417762 ENST00000367505 ENST00000438092 ENST00000275233 ENST00000433355(uc003qlg.1)
    ENST00000519632(uc003qlh.3 uc003qlj.1) ENST00000523276(uc003qli.1)
    ENST00000520752 ENST00000521977 ENST00000367503(uc003qlf.3 uc003qle.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SHPRH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SHPRH (see all 19):
    hsa-miR-520d-5p hsa-miR-29a hsa-miR-29c hsa-miR-501-3p hsa-miR-3692 hsa-miR-502-3p hsa-miR-548a-3p hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidSHPRH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SHPRH
    Predesigned siRNA for gene silencing in human, mouse, rat SHPRH
    Clone
    Products:
         
    OriGene clones in human, mouse for SHPRH (see all 12)
    OriGene ORF clones in mouse, rat for SHPRH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SHPRH (NM_173082)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHPRH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHPRH
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SHPRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHPRH
      QuantiTect SYBR Green Assays in human, mouse, rat SHPRH
      QuantiFast Probe-based Assays in human, mouse, rat SHPRH

    Selected AceView cDNA sequences (see all 107):

    AV704509 BX113386 BX504969 BM931244 AA255426 AA602111 AI888407 AA333210 
    AI682169 AA443760 AI631201 AL833521 AI479552 BU072582 AK126959 AY163808 
    BQ014853 AA476814 C04062 AI224908 CA390223 BX362621 CR615021 AI148338 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SHPRH    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                    -           -                           
    SP3:                                                                                                                                                            
    SP4:              -     -                                                                                                                                       
    SP5:              -     -                                                                                                                                       

    ExUns: 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
    SP1:  -                             -                                               -               
    SP2:                                -                                                               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SHPRH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SHPRH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATAATTT
    SHPRH Expression
    About this image

    SHPRH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHPRH Protein Expression

    UniProtKB/Swiss-Prot: SHPRH_HUMAN, Q149N8
    Tissue specificity: Broadly expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SHPRH: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SHPRH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHPRH
    QuantiTect SYBR Green Assays in human, mouse, rat SHPRH
    QuantiFast Probe-based Assays in human, mouse, rat SHPRH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHPRH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SHPRH gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shprh1 , 5 SNF2 histone linker PHD RING helicase1, 5 85.5(n)1
    86.42(a)1
      10 (3.66 cM)5
    2682811  NM_001077707.11  NP_001071175.11 
     111494275 
    chicken
    (Gallus gallus)
    Aves SHPRH1 SNF2 histone linker PHD RING helicase, E3 ubiquitin more 72.79(n)
    72.85(a)
      421613  XM_419651.4  XP_419651.3 
    lizard
    (Anolis carolinensis)
    Reptilia SHPRH6
    SNF2 histone linker PHD RING helicase, E3 ubiquiti...
    71(a)
    1 ↔ 1
    1(207133276-207185823)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia shprh1 SNF2 histone linker PHD RING helicase, E3 ubiquitin more 67.99(n)
    68.62(a)
      101733375  XM_004914893.1  XP_004914950.1 
    zebrafish
    (Danio rerio)
    Actinopterygii shprh1 SNF2 histone linker PHD RING helicase 63.63(n)
    64.93(a)
      560526  XM_003200310.2  XP_003200358.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73761 CG7376 45.39(n)
    34.94(a)
      38715  NM_139777.2  NP_648034.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T05A12.46
    Protein T05A12.4, isoform b (T05A12.4) mRNA, compl...
    16(a)
    1 ↔ 1
    IV(6887948-6897777) WBGene00020235
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IRC20(YLR247C)4 Putative helicase; localizes to the mitochondrion and more   --   12(633354-628684) 850949  NP_013348.1 


    ENSEMBL Gene Tree for SHPRH (if available)
    TreeFam Gene Tree for SHPRH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SHPRH gene
    5 SIMAP similar genes for SHPRH using alignment to 5 protein entries:     SHPRH_HUMAN (see all proteins):
    ERCC6L    BTAF1    CHD4    CHD5    ATRX

    Find genes that share paralogs with SHPRH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SHPRH (see all 1524)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0318584
    A melanoma cell line4--see VAR_0318582 S F mis40--------
    VAR_0318574
    An ovarian cancer cell line4--see VAR_0318572 Q R mis40--------
    VAR_0318594
    A melanoma cell line4--see VAR_0318592 N Y mis40--------
    rs1447648581,2
    C--146208258(+) AACAAC/TTCATA 2 -- int10--------
    rs729999141,2
    C,F--146208401(+) ATCAAT/AGGAAG 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1485577401,2
    --146208434(+) TTCTTG/TGCTAT 2 -- int10--------
    rs1869339401,2
    --146208518(+) AAAGAC/TTTATG 2 -- int10--------
    rs1913980381,2
    C--146208576(+) TATGAG/TTCCAG 2 -- int10--------
    rs1857518941,2
    C--146208606(+) AGACTA/GGTTTA 2 -- int10--------
    rs22437571,2
    C,A--146208669(+) AGTTTT/GTTTTT 2 -- int14Minor allele frequency- G:0.14NA WA CSA 7

    HapMap Linkage Disequilibrium report for SHPRH (146185381 - 146285559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SHPRH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830835CNV Loss17160897
    nsv437525CNV Loss16327808

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SHPRH
    DNA2.0 Custom Variant and Variant Library Synthesis for SHPRH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608048    OMIM disorders: --


    Find genes that share disorders with SHPRH           About GenesLikeMe

    Genetic Association Database (GAD): SHPRH
    Human Genome Epidemiology (HuGE) Navigator: SHPRH (1 document)

    Export disorders for SHPRH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SHPRH gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SHPRH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region. (PubMed id 12837266)1, 2, 3, 9 Sood R.... Trent J.M. (Genomics 2003)
    2. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PubMed id 17108083)1, 2, 9 Unk I.... Haracska L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)1, 2 Motegi A.... Myung K. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. (PubMed id 17130289)1, 2 Motegi A.... Myung K. (J. Cell Biol. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival. (PubMed id 23555860)1 Sertic S....Rotondo G. (PLoS ONE 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Human CCAAT/enhancer-binding protein I^ interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)1 Steinberg X.P....GutiAcrrez J.L. (Biochemistry 2012)
    10. SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis. (PubMed id 21396873)1 Lin J.R....Cimprich K.A. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 257218 HGNC: 19336 AceView: SHPRH Ensembl:ENSG00000146414 euGenes: HUgn257218
    ECgene: SHPRH H-InvDB: SHPRH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA2023

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SHPRH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SHPRH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SHPRH gene:
    Search GeneIP for patents involving SHPRH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SHPRH   OriGene RNAi products in human, mouse, rat for SHPRH  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SHPRH  
     OriGene qSTAR qPCR primer pairs in human, mouse for SHPRH   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SHPRH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SHPRH   OriGene Custom Protein Services for SHPRH  

     
     
     Block miRNA regulation of human, mouse, rat SHPRH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SHPRH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHPRH Predesigned siRNA for gene silencing in human, mouse, rat SHPRH
     QuantiFast Probe-based Assays in human, mouse, rat SHPRH QuantiTect SYBR Green Assays in human, mouse, rat SHPRH
     PCR Arrays including human, mouse, rat SHPRH Search Chromatin IP Primers for SHPRH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHPRH  GeneGlobe Interaction Network for SHPRH
     Regulatory tfbs in SHPRH promoter
     GenScript Custom Purified and Recombinant Proteins Services for SHPRH GenScript cDNA clones with any tag delivered in your preferred vector for SHPRH
     GenScript Custom Assay Services for SHPRH GenScript Custom overexpressing Cell Line Services for SHPRH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SHPRH
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SHPRH antibodies
     SHPRH proteins
     SHPRH lysates
     Antibodies for SHPRH
     See all of Abcam's Antibodies, Kits and Proteins for SHPRH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SHPRH
     Antibodies for SHPRH
     ELISAs for SHPRH
     CLIAs for SHPRH



     Browse ESI BIO Cell Lines and PureStem Progenitors for SHPRH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHPRH
     SwitchGear 3'UTR luciferase reporter plasmids for SHPRH
     SwitchGear Promoter luciferase reporter plasmids for SHPRH
     Search ThermoFisher Antibodies for SHPRH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHPRH
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHPRH
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SHPRH
     LSBio Antibodies in human, mouse, rat for SHPRH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SHPRH
      Search eBioscience for proteins for SHPRH
      Search eBioscience for elisas for SHPRH
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SHPRH gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4