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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHPK Gene

protein-coding   GIFtS: 51
GCID: GC17M003514

Sedoheptulokinase

(Previous name: carbohydrate kinase-like)
(Previous symbol: CARKL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
sedoheptulokinase1 2
CARKL1 2 3 5
Carbohydrate Kinase-Like Protein2 3
SHK2 3
Carbohydrate Kinase-Like1
EC 2.7.1.143

External Ids:    HGNC: 14921   Entrez Gene: 237292   Ensembl: ENSG000001974177   OMIM: 6050605   UniProtKB: Q9UHJ63   

Export aliases for SHPK gene to outside databases

Previous GC identifers: GC17M003459 GC17M003403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHPK Gene:
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved
in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence
variation between this novel gene and known carbohydrate kinases suggests the possibility of a different
substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene
resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis
phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal
rearrangements. (provided by RefSeq, Jul 2008)

GeneCards Summary for SHPK Gene: 
SHPK (sedoheptulokinase) is a protein-coding gene. Diseases associated with SHPK include nephropathic cystinosis, and cystinosis. GO annotations related to this gene include sedoheptulokinase activity and ATP binding.

UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
Function: Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHPK gene promoter:
         USF1   AML1a   Tal-1   E47   FAC1   FOXJ2 (long isoform)   USF-1   FOXJ2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHPK promoter sequence
   Search SABiosciences Chromatin IP Primers for SHPK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

SHPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHPK gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003514:  view genomic region     (about GC identifiers)

Start:
3,511,556 bp from pter      End:
3,539,616 bp from pter
Size:
28,061 bases      Orientation:
minus strand

1 alternative location:
Chr17- 3,468,738-3,539,543     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6 (See protein sequence)
Recommended Name: Sedoheptulokinase  
Size: 478 amino acids; 51491 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B2R640 Q8WUH3

Explore the universe of human proteins at neXtProt for SHPK: NX_Q9UHJ6

Explore proteomics data for SHPK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHJ6

  • SHPK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHPK Protein Expression
    REFSEQ proteins: NP_037408.2  
    ENSEMBL proteins: 
     ENSP00000225519  

    Human Recombinant Protein Products for SHPK: 
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    Sino Biological Cell Lysate for SHPK 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    SHPK for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018484 Carb_kinase_FGGY_N

    Graphical View of Domain Structure for InterPro Entry Q9UHJ6

    ProtoNet protein and cluster: Q9UHJ6

    UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
    Similarity: Belongs to the FGGY kinase family


    SHPK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHPK_HUMAN, Q9UHJ6
    Function: Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity)
    Catalytic activity: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.06 mM for sedoheptulose; pH dependence: Optimum pH is 8.5;
    Induction: Down-regulated by LPS

         Enzyme Number (IUBMB): EC 2.7.1.141

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
    GO:0050277sedoheptulokinase activity IDA19413330
         
    SHPK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SHPK:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SHPK 
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    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SHPK:
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    SwitchGear 3'UTR luciferase reporter plasmidSHPK 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHPK

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SHPK (ENSP000002255194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    MDM2ENSP000004172814STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IDA19413330
    GO:0009052pentose-phosphate shunt, non-oxidative branch ISS--
    GO:0016310phosphorylation IDA19413330
    GO:0035963cellular response to interleukin-13 ISS--
    GO:0043030regulation of macrophage activation ISS--

    SHPK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHPK

    6 HMDB Compounds for SHPK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Inositol 1,3,4,5,6-pentakisphosphate1D-myo-Inositol 1,3,4,5,6-pentakisphosphate (see all 5)20298-95-7--
    Myo-inositol hexakisphosphate1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate (see all 9)83-86-3--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--

    Search CenterWatch for drugs/clinical trials and news about SHPK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHPK gene: 
    NM_013276.2  

    Unigene Cluster for SHPK:

    Sedoheptulokinase
    Hs.579217  [show with all ESTs]
    Unigene Representative Sequence: AF163573
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225519(uc002fvz.1)
    miRNA
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    hsa-miR-3618 hsa-miR-124 hsa-miR-3662 hsa-miR-506 hsa-miR-450b-3p hsa-miR-324-5p hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidSHPK 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHPK
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    Additional mRNA sequence: 

    AF163573.1 AK055609.1 AK057020.1 AK057040.1 AK298360.1 AK312428.1 AL832420.1 BC020543.1 
    BC111366.1 

    4 DOTS entries:

    DT.428676  DT.97819296  DT.97806108  DT.102826144 

    24/121 AceView cDNA sequences (see all 121):

    BQ187326 BQ959791 BM676314 AA331298 NM_013276 CA307823 BP346171 AI245655 
    BQ676342 BX096339 AF163573 AA325795 CK300648 AJ277028 CB044884 AA700014 
    AA410918 BM014650 AA411042 BM704676 BX117112 BG034978 BF766095 AA618422 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHPK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTCAGTTA
    SHPK Expression
    About this image


    See SHPK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHPK

    SOURCE GeneReport for Unigene cluster: Hs.579217

    UniProtKB/Swiss-Prot: SHPK_HUMAN, Q9UHJ6
    Tissue specificity: Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and
    heart. Very weakly expressed in lung and brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SHPK gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shpk1 , 5 sedoheptulokinase1, 5 85.75(n)1
    87.79(a)1
      11 (45.25 cM)5
    746371  NM_029031.31  NP_083307.11 
     731994605 
    chicken
    (Gallus gallus)
    Aves SHPK1 sedoheptulokinase 67.53(n)
    65.81(a)
      417607  XM_415852.3  XP_415852.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39962 Xenopus laevis transcribed sequence with weak similarity more 72.64(n)    BX851895.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000016761 novel protein similar to vertebrate carbohydrate kinase-like more 61.41(n)
    57.78(a)
      100001676  XM_001341591.3  XP_001341627.3 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T25C8.11 Protein T25C8.1 41.58(n)
    34.64(a)
      188886  NM_067409.2  NP_499810.2 


    ENSEMBL Gene Tree for SHPK (if available)
    TreeFam Gene Tree for SHPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 SNPs in SHPK are shown (see all 563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0485914
    ----see VAR_0485912 D E mis40--------
    VAR_0485924
    ----see VAR_0485922 L M mis40--------
    rs1400886331,2
    --3406472(+) TTAACC/TGGGCG 1 -- int10--------
    rs1436570851,2
    --3406529(+) GAGAAG/TCACTT 1 -- int10--------
    rs1462522321,2
    --3406579(+) CCACTA/GCACTC 1 -- int10--------
    rs27371411,2
    C,F,O,H--3406655(+) TGTCAT/CTGGGG 1 -- int125Minor allele frequency- C:0.13NS EA NA WA 2906
    rs760563011,2
    C,F--3406707(+) CTGAAT/CGGGCC 1 -- int11Minor allele frequency- C:0.06NA 120
    rs620699291,2
    C,F--3406974(+) GTATTT/CTTAGT 1 -- int13Minor allele frequency- C:0.20NA WA 124
    rs1874102861,2
    --3407000(+) CTACAG/TTGGAC 1 -- int10--------
    rs1392811261,2
    --3407009(+) ACAGGC/GTGGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SHPK (3511556 - 3539616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SHPK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662762CNV Deletion23128226
    esv997341CNV Deletion20482838
    nsv833342CNV Loss17160897
    nsv907568CNV Loss21882294
    dgv358n27CNV Loss19166990
    nsv907565CNV Loss21882294
    nsv526175CNV Gain19592680
    nsv516676CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605060    OMIM disorders: --

    3 diseases for SHPK:    About MalaCards
    nephropathic cystinosis    cystinosis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for SHPK:
    Cystinosis

    SHPK for disorders           About GeneDecksing

    Genetic Association Database (GAD): SHPK
    Human Genome Epidemiology (HuGE) Navigator: SHPK (4 documents)

    Export disorders for SHPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHPK gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SHPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene. (PubMed id 18186520)1, 2, 3, 9 Wamelink M.M....Wevers R.A. (2008)
    2. The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. (PubMed id 10673275)1, 2, 3, 9 Touchman J.W....Green E.D. (2000)
    3. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. (PubMed id 22682222)1, 2 Haschemi A.... Wagner O. (2012)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Multi-ethnic genetic association study of carotid int ima-media thickness using a targeted cardiovascular SNP microarray. (PubMed id 19679847)1, 4 Lanktree M.B....Anand S.S. (2009)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)1, 2 Gauci S....Mohammed S. (2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23729 HGNC: 1492 AceView: CARKL Ensembl:ENSG00000197417 euGenes: HUgn23729
    ECgene: SHPK H-InvDB: SHPK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHPK gene:
    Search GeneIP for patents involving SHPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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