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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHOX2 Gene

protein-coding   GIFtS: 53
GCID: GC03M157813

short stature homeobox 2
 Explore 6 diseases affiliated with
SHOX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SHOX2    

Aliases
for SHOX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Short Stature Homeobox 21 2     Homeobox Protein Og12X2 3
SHOT1 2 3 5     Paired-Related Homeobox Protein SHOT2 3
OG12X1 2 3     Short Stature Homeobox Protein 22
OG121 2 5     SHOX Homologous Gene On Chromosome 32

External Ids:    HGNC: 108541   Entrez Gene: 64742   Ensembl: ENSG000001687797   OMIM: 6025045   UniProtKB: O609023   

Export aliases for SHOX2 gene to outside databases

Previous GC identifers: GC03M154850 GC03M158760 GC03M159095 GC03M159135 GC03M159297 GC03M155210


Summaries
for SHOX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SHOX2:
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif
that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators
involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused
by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be
responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome
patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
Function: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory
information, as well as in face and body structure formation

Gene Wiki entry for SHOX2


Genomic Views
for SHOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHOX2 gene promoter:
         AREB6   CP2   COMP1   aMEF-2   CUTL1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SHOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.32   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.32

SHOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHOX2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M157813:  view genomic region     (about GC identifiers)

Start:
 157,813,743 bp from pter      End:
 157,824,292 bp from pter
Size:
 10,550 bases      Orientation:
 minus strand

Proteins
for SHOX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902 (See protein sequence)
Recommended Name: Short stature homeobox protein 2  
Size: 331 amino acids; 34953 Da
Subcellular location: Nucleus
Developmental stage: Expressed during cranofacial development as well as in heart
Sequence caution: Sequence=AAC39662.1; Type=Erroneous initiation; Sequence=CAA05341.1; Type=Erroneous initiation;
Sequence=CAA05342.1; Type=Erroneous initiation;
Secondary accessions: O60465 O60467 O60903
Alternative splicing: 3 isoforms:  O60902-1   O60902-2   O60902-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHOX2: NX_O60902

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60902

    • SHOX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157150.1  NP_003021.3  NP_006875.2  

    ENSEMBL proteins: 
     ENSP00000398704   ENSP00000451888   ENSP00000374240   ENSP00000450720   ENSP00000397099  

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    OriGene Protein Over-expression Lysate (see all 2): SHOX2
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    Novus Biologicals SHOX2 Proteins
    Novus Biologicals SHOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SHOX2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SHOX2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SHOX2

    Protein Domains /
    Families
    for SHOX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SHOX2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60902

    ProtoNet protein and cluster: O60902

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for SHOX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
    Function: May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory
    information, as well as in face and body structure formation

         Genatlas biochemistry entry for SHOX2:
    murine homeo box Og12X homolog,strongly expressed in developing craniofacial,brain,heart and in the mesenchym of
    developing limbs,highly homologous to SHOX

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHOX2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SHOX2 (see all 51):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-miR-875-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: SHOX2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SHOX2
    OriGene siRNA: SHOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHOX2

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SHOX2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    SHOX2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SHOX2:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-outs for SHOX2: Shox2tm1.1Ddu Shox2tm1Acgg Shox2tm1Ypc
         8 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Shox2):
     cardiovascular system  craniofacial  digestive/alimentary  growth/size  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  skeleton 

    SHOX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SHOX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHOX2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SHOX2 (O609023 ENSP000003742404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM29Q141343, ENSP000003431294I2D: score=1 STRING: ENSP00000343129
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    CDK4ENSP000002579044STRING: ENSP00000257904
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001501skeletal system development TAS9482898
    GO:0001649osteoblast differentiation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002063chondrocyte development IEA--


    SHOX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SHOX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHOX2
    Search CenterWatch for drugs/clinical trials and news about SHOX2 

    Transcripts
    for SHOX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SHOX2 gene (3 alternative transcripts): 
    NM_001163678.1  NM_003030.4  NM_006884.3  

    Unigene Cluster for SHOX2:

    Short stature homeobox 2
    Hs.55967  [show with all ESTs]
    Unigene Representative Sequence: NM_003030
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425436(uc003fbs.3 uc003fbr.3 uc010hvw.3) ENST00000490689
    ENST00000389589 ENST00000555977 ENST00000554685 ENST00000441443

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SHOX2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SHOX2 (see all 51):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-miR-875-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: SHOX2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHOX2 (see all 7)
    OriGene shRNA RFP: SHOX2
    OriGene siRNA: SHOX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHOX2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOX2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOX2

    Additional cDNA sequence: 

    AF022654.1 AK095338.1 BC008829.2 

    4 DOTS entries:

    DT.114552  DT.95161535  DT.91662085  DT.100751167 

    24/47 AceView cDNA sequences (see all 47):

    AI088265 AI131445 AA450208 AI332507 AA425419 AA425293 AA333177 BQ233296 
    AF022654 AA833689 AI126714 AA425429 NM_006884 AA425170 AI831264 AI277252 
    NM_003030 BC008829 AJ002367 AI816713 BV199885 AI016607 AJ002368 AA235793 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SHOX2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -           -     -                                       
    SP2:                    -     -     -     -                                       
    SP3:                    -     -     -     -                       -               
    SP4:                                                              -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for SHOX2

    Expression
    for SHOX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHOX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGTGTTGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SHOX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageTemporomandibular JointChondrocytesBone, Cartilage
    CartilageTemporomandibular JointCondylar Condensation CellsBone, Cartilage
    CartilageTemporomandibular JointGlenoid Fossa CellsBone, Cartilage
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SHOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHOX2

    SOURCE GeneReport for Unigene cluster: Hs.55967

    UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
    Tissue specificity: Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including SHOX2: 
              Hedgehog Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX2

    Orthologs
    for SHOX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SHOX2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SHOX21 short stature homeobox 2 72.11(n)
    78.23(a)    		   777244  XM_003641797.1  XP_003641845.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SHOX26
    		 --
    		 88(a)
    		 1 → many
    		 3(14433463-14447877)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX731714.12   -- 84.84(n)    BX731714.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc658842 similar to short stature homeobox 2 84.52(n)   394171  BC056324.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG343671 CG34367 57.47(n)
    53.85(a)    		   5740879  NM_001103670.2  NP_001097140.1 


    ENSEMBL Gene Tree for SHOX2 (if available)
    TreeFam Gene Tree for SHOX2 (if available) 

    Paralogs
    for SHOX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHOX2 gene
    UNCX2  ENSG000002585182  SHOX2  OTP2  
    18/23 SIMAP similar genes for SHOX2 using alignment to 3 protein entries:     SHOX2_HUMAN (see all proteins) (see all similar genes):
    SHOX    OTX2    PRRX1    NKX2-5    HOXB1    PITX2
    PRRX2    PAX6    PHOX2B    HOXA4    MNX1    DUX2
    MEOX1    PITX1    RAX2    OTX1    PROP1    RHOXF1

    SHOX2 for paralogs           About GeneDecksing



    Genomic Variants
    for SHOX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in SHOX2 are shown (see all 205)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs747317641,2
    		--155222657(+) GTTCCA/GTCAAA 1 -- us2k10--------
    rs772414041,2
    		C,--157813357(+) GAGAGG/AGTCAA 3 -- ds50011Minor allele frequency- A:0.01EA 120
    rs11231151,2
    		C,F,H,--157813401(-) AACCTA/GGGTTT 3 -- ds500126Minor allele frequency- N:0.00NS EA NA WA 2908
    rs1914138071,2
    		--157813585(+) TGCTGA/GGTGGA 3 -- ds50010--------
    rs1502080701,2
    		--157813596(+) TAAAAA/TGGAGG 3 -- ds50010--------
    rs2018520961,2
    		--157813676(+) GCACG-/TTAAGA 3 -- ds50010--------
    rs1388057711,2
    		--157813720(+) CGAGAA/GAGTGA 3 -- ds50010--------
    rs2019356391,2
    		--157813966(+) AAAAA-/TATGTC 3 -- ut310--------
    rs2002292431,2
    		--157814095(+) AAAAC-/AAAACC 3 -- ut310--------
    rs1835022671,2
    		--157814101(+) AAACCC/TCACAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SHOX2 (157813743 - 157824292 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SHOX2: --

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    Disorders / Diseases
    for SHOX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SHOX2 for disorders           About GeneDecksing

    OMIM gene information: 602504    OMIM disorders: --

    6 diseases for SHOX2:    About MalaCards
    cornelia de lange syndrome    short stature    turner syndrome    hard palate cancer
    lung cancer    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SHOX2:
    Hard palate cancer     Turner syndrome

    1 Novoseek disease relationship for SHOX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cornelia de lange syndrome 84.5 2 9466998 (1), 9482898 (1)

    Human Genome Epidemiology (HuGE) Navigator: SHOX2 (2 documents)

    Export disorders for SHOX2 gene to outside databases

    Publications
    for SHOX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHOX2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SHOX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse. (PubMed id 9466998)1, 2, 3, 9 Semina E.V....Murray J.C. (1998)
    2. SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. (PubMed id 9482898)1, 2, 3, 9 Blaschke R.J.... Rappold G.A. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients. (PubMed id 22555092)1 Dietrich D....Soltermann A. (2012)
    6. Performance evaluation of the DNA methylation biomarke r SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchi al aspirates. (PubMed id 22108652)1 Dietrich D....Field J.K. (2012)
    7. Correlation of SHOX2 gene amplification and DNA methy lation in lung cancer tumors. (PubMed id 21426551)1 Schneider K.U....Schmidt B. (2011)
    8. SHOX2 DNA methylation is a biomarker for the diagnosi s of lung cancer in plasma. (PubMed id 21694641)1 Kneip C....Dietrich D. (2011)
    9. SHOX2 DNA methylation is a biomarker for the diagnosi s of lung cancer based on bronchial aspirates. (PubMed id 21047392)1 Schmidt B....Field J.K. (2010)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)

    External Searches for SHOX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SHOX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6474 HGNC: 10854 AceView: SHOX2 Ensembl:ENSG00000168779 euGenes: HUgn6474
    ECgene: SHOX2 H-InvDB: SHOX2

    Other Databases showing SHOX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SHOX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHOX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SHOX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SHOX2 gene:
    Search GeneIP for patents involving SHOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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