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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHOX2 Gene

protein-coding   GIFtS: 54
GCID: GC03M157813

Short Stature Homeobox 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Short Stature Homeobox 21 2     OG12X2 3
SHOT2 3 5     OG122 5
Homeobox Protein Og12X2 3     Short Stature Homeobox Protein 22
Paired-Related Homeobox Protein SHOT2 3     SHOX Homologous Gene On Chromosome 32

External Ids:    HGNC: 108541   Entrez Gene: 64742   Ensembl: ENSG000001687797   OMIM: 6025045   UniProtKB: O609023   

Export aliases for SHOX2 gene to outside databases

Previous GC identifers: GC03M154850 GC03M158760 GC03M159095 GC03M159135 GC03M159297 GC03M155210


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHOX2 Gene:
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue
motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional
regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic
disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox
gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature
phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange
syndrome. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2009)

GeneCards Summary for SHOX2 Gene: 
SHOX2 (short stature homeobox 2) is a protein-coding gene. Diseases associated with SHOX2 include hard palate cancer, and cornelia de lange syndrome. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
Function: May be a growth regulator and have a role in specifying neural systems involved in processing
somatosensory information, as well as in face and body structure formation

Gene Wiki entry for SHOX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHOX2 gene promoter:
         AREB6   CP2   COMP1   aMEF-2   CUTL1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SHOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.32   Ensembl cytogenetic band:  3q25.32   HGNC cytogenetic band: 3q25.32

SHOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHOX2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M157813:  view genomic region     (about GC identifiers)

Start:
157,813,800 bp from pter      End:
157,824,292 bp from pter
Size:
10,493 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902 (See protein sequence)
Recommended Name: Short stature homeobox protein 2  
Size: 331 amino acids; 34953 Da
Subcellular location: Nucleus
Developmental stage: Expressed during cranofacial development as well as in heart
Sequence caution: Sequence=AAC39662.1; Type=Erroneous initiation; Sequence=CAA05341.1; Type=Erroneous initiation;
Sequence=CAA05342.1; Type=Erroneous initiation;
Secondary accessions: O60465 O60467 O60903
Alternative splicing: 3 isoforms:  O60902-1   O60902-2   O60902-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHOX2: NX_O60902

Explore proteomics data for SHOX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60902

  • SHOX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SHOX2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001157150.1  NP_003021.3  NP_006875.2  

    ENSEMBL proteins: 
     ENSP00000451888   ENSP00000398704   ENSP00000374240   ENSP00000419362   ENSP00000397099  

    Human Recombinant Protein Products for SHOX2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SHOX2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SHOX2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    5 InterPro protein domains:
     IPR000047 HTH_motif
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60902

    ProtoNet protein and cluster: O60902

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    SHOX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SHOX2_HUMAN, O60902
    Function: May be a growth regulator and have a role in specifying neural systems involved in processing
    somatosensory information, as well as in face and body structure formation

         Genatlas biochemistry entry for SHOX2:
    murine homeo box Og12X homolog,strongly expressed in developing craniofacial,brain,heart and in the mesenchym of
    developing limbs,highly homologous to SHOX

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    SHOX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SHOX2:
     Decreased viability of wild-ty 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Shox2):
     cardiovascular system  craniofacial  digestive/alimentary  growth/size  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  skeleton 

    SHOX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SHOX2: Shox2tm1.1Ddu Shox2tm1Acgg Shox2tm1Ypc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SHOX2 
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    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SHOX2 (see all 51):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-miR-875-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSHOX2 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHOX2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SHOX2 (O609023 ENSP000003742404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM29Q141343, ENSP000003431294I2D: score=1 STRING: ENSP00000343129
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    CDK4ENSP000002579044STRING: ENSP00000257904
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001501skeletal system development TAS9482898
    GO:0001649osteoblast differentiation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002062chondrocyte differentiation ----

    SHOX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHOX2

    Search CenterWatch for drugs/clinical trials and news about SHOX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHOX2 gene (3 alternative transcripts): 
    NM_001163678.1  NM_003030.4  NM_006884.3  

    Unigene Cluster for SHOX2:

    Short stature homeobox 2
    Hs.55967  [show with all ESTs]
    Unigene Representative Sequence: NM_003030
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490689 ENST00000425436(uc003fbs.3 uc003fbr.3 uc010hvw.3)
    ENST00000389589 ENST00000483851 ENST00000554685 ENST00000441443
    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate SHOX2 (see all 51):
    hsa-miR-579 hsa-miR-4291 hsa-miR-607 hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-miR-875-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSHOX2 3' UTR sequence
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOX2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOX2

    Additional mRNA sequence: 

    AF022654.1 AK095338.1 BC008829.2 

    4 DOTS entries:

    DT.114552  DT.95161535  DT.91662085  DT.100751167 

    24/47 AceView cDNA sequences (see all 47):

    AA333177 AI332507 AA425293 AI088265 AI131445 AA425419 AA450208 AJ002367 
    AI831264 BV199885 NM_003030 AA425170 AA235793 AI816713 AJ002368 BC008829 
    NM_006884 BQ233296 AI277252 AI016607 AF022654 AA833689 AK095338 AA425429 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SHOX2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -           -     -                                       
    SP2:                    -     -     -     -                                       
    SP3:                    -     -     -     -                       -               
    SP4:                                                              -               
    SP5:                                                                              


    ECgene alternative splicing isoforms for SHOX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHOX2 expression in normal human tissues (normalized intensities)      SHOX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTGTTGTC
    SHOX2 Expression
    About this image


    SHOX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Glenoid Fossa Cells Temporomandibular Joint
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Glenoid Fossa Cells Temporomandibular Joint
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/forelimb   
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate

    See SHOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHOX2

    SOURCE GeneReport for Unigene cluster: Hs.55967

    UniProtKB/Swiss-Prot: SHOX2_HUMAN, O60902
    Tissue specificity: Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and
    placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including SHOX2: 
              Hedgehog Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SHOX2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shox21 , 5 short stature homeobox 21, 5 94.04(n)1
    98.79(a)1
      3 (30.76 cM)5
    204291  NM_013665.11  NP_038693.11 
     669717275 
    chicken
    (Gallus gallus)
    Aves SHOX21 short stature homeobox 2 72.11(n)
    78.23(a)
      777244  XM_003641797.1  XP_003641845.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    3(14433463-14447877)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX731714.12   -- 84.84(n)    BX731714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658842 similar to short stature homeobox 2 84.52(n)   394171  BC056324.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343671 CG34367 57.47(n)
    53.85(a)
      5740879  NM_001103670.2  NP_001097140.1 


    ENSEMBL Gene Tree for SHOX2 (if available)
    TreeFam Gene Tree for SHOX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHOX2 gene
    ALX12  PHOX2B2  ARX2  RAX2  DRGX2  PRRX12  PHOX2A2  ALX42  
    ISX2  RAX22  ALX32  SHOX2  OTP2  PRRX22  
    18/19 SIMAP similar genes for SHOX2 using alignment to 3 protein entries:     SHOX2_HUMAN (see all proteins) (see all similar genes):
    SHOX    OTX2    PHOX2B    PHOX2A    PRRX1    PRRX2
    NKX2-5    HOXB1    PITX2    PAX6    MNX1    DUX2
    DUX4    RAX2    OTX1    PROP1    RHOXF1    PAX-3

    SHOX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/261 SNPs in SHOX2 are shown (see all 261)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772414041,2
    C--157813357(+) GAGAGG/AGTCAA 3 -- ds50011Minor allele frequency- A:0.01EA 120
    rs11231151,2
    C,F,H--157813401(-) AACCTA/GGGTTT 3 -- ds500126Minor allele frequency- N:0.00NS EA NA WA 2908
    rs1914138071,2
    --157813585(+) TGCTGA/GGTGGA 3 -- ds50010--------
    rs1502080701,2
    --157813596(+) TAAAAA/TGGAGG 3 -- ds50010--------
    rs2018520961,2
    C--157813676(+) GCACG-/TTAAGA 3 -- ds50010--------
    rs1388057711,2
    C--157813720(+) CGAGAA/GAGTGA 3 -- ds50010--------
    rs2019356391,2
    --157813966(+) AAAAA-/TATGTC 3 -- ut310--------
    rs2002292431,2
    C--157814095(+) AAAAC-/AAAACC 3 -- ut310--------
    rs1835022671,2
    --157814101(+) AAACCC/TCACAA 3 -- ut310--------
    rs1141475081,2
    C,F--157814181(+) TGAATT/GGAAAC 3 -- ut311Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for SHOX2 (157813800 - 157824292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SHOX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877688CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602504    OMIM disorders: --

    6 diseases for SHOX2:    About MalaCards
    hard palate cancer    cornelia de lange syndrome    turner syndrome    idiopathic short stature
    short stature    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for SHOX2:
    Hard palate cancer     Turner syndrome

    SHOX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SHOX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cornelia de lange syndrome 84.5 2 9466998 (1), 9482898 (1)

    Genetic Association Database (GAD): SHOX2
    Human Genome Epidemiology (HuGE) Navigator: SHOX2 (2 documents)

    Export disorders for SHOX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHOX2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SHOX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse. (PubMed id 9466998)1, 2, 3, 9 Semina E.V....Murray J.C. (1998)
    2. SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. (PubMed id 9482898)1, 2, 3, 9 Blaschke R.J.... Rappold G.A. (1998)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. Genome-wide meta-analysis identifies 11 new loci for a nthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (2013)
    7. DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients. (PubMed id 22555092)1 Dietrich D....Soltermann A. (2012)
    8. Performance evaluation of the DNA methylation biomarke r SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchi al aspirates. (PubMed id 22108652)1 Dietrich D....Field J.K. (2012)
    9. Correlation of SHOX2 gene amplification and DNA methy lation in lung cancer tumors. (PubMed id 21426551)1 Schneider K.U....Schmidt B. (2011)
    10. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6474 HGNC: 10854 AceView: SHOX2 Ensembl:ENSG00000168779 euGenes: HUgn6474
    ECgene: SHOX2 H-InvDB: SHOX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHOX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHOX2 gene:
    Search GeneIP for patents involving SHOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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