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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SHOX Gene

protein-coding   GIFtS: 55
GCID: GC0XP000585

short stature homeobox

 Explore 30 diseases affiliated with
SHOX via our new
 Human Malady Compendium 
Biological research products
for SHOX
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Short Stature Homeobox1 2     Pseudoautosomal Homeobox-Containing Osteogenic Protein2 3
PHOG1 2 3 5     Growth Control Factor, X-Linked2
GCFX1 2 5     Short Stature Homeobox Protein2
SS1 2 5     Short Stature Homeobox-Containing Protein3
SHOXY1 2     

External Ids:    HGNC: 108531   Entrez Gene: 64732   Ensembl: ENSG000001859607   OMIM: 3128655   UniProtKB: O152663   

Export aliases for SHOX gene to outside databases

Previous GC identifers: GC0XP000427 GC0YU900006 GC0XP000527 GC0YP000555


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SHOX:
This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype
of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively
spliced transcript variants encoding different isoforms have been noted for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
Function: Controls fundamental aspects of growth and development

Gene Wiki entry for SHOX (Short stature homeobox gene)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.1  NT_167193.1  NT_167201.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SHOX gene promoter:
         PPAR-alpha   SRY   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHOX promoter sequence
   Search SABiosciences Chromatin IP Primers for SHOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33;Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11.32

SHOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHOX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP000585:  view genomic region     (about GC identifiers)

Start:
585,079 bp from pter      End:
620,146 bp from pter
Size:
35,068 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 535,079-570,146     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266 (See protein sequence)
Recommended Name: Short stature homeobox protein  
Size: 292 amino acids; 32236 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: O00412 O00413 O15267
Alternative splicing: 2 isoforms:  O15266-1   O15266-2   

Explore the universe of human proteins at neXtProt for SHOX: NX_O15266

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15266

  • SHOX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000442.1  NP_006874.1  

    ENSEMBL proteins: 
     ENSP00000453617   ENSP00000452016   ENSP00000453707   ENSP00000453225   ENSP00000370987  
     ENSP00000335505   ENSP00000370990  

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    Uscn Proteins for SHOX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SHOX for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SHOX for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000047 HTH_motif
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O15266

    ProtoNet protein and cluster: O15266

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
    Similarity: Belongs to the paired homeobox family. Bicoid subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
    Function: Controls fundamental aspects of growth and development
    Induction: By retinoic acid and phorbol-12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for SHOX:
    short stature homeo box-containing gene,with two alternatively spliced forms SHOXa widely expressed,and SHOXb
    predominantly found in bone marrow,fibroblast,homolog to murine OG-12a,OG-12b

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    hsa-miR-92a hsa-miR-137 hsa-miR-196a* hsa-miR-374b hsa-miR-25 hsa-miR-367 hsa-miR-16-1* hsa-miR-374a
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--


    SHOX for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SHOX:
     Decreased TP53 protein express 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHOX

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SHOX (O152661, 3 ENSP000003709904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOX5P357111, 3, ENSP000003089274EBI-3505698,EBI-3505701 I2D: score=1 STRING: ENSP00000308927
    SOX6P357121, 3EBI-3505698,EBI-3505706 I2D: score=1 
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    --ENSP000003369464STRING: ENSP00000336946
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9590292
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS9259282


    SHOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SHOX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SHOX
    2 Novoseek chemical compound relationships for SHOX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 0 2 12153748 (1), 11260213 (1)
    estrogen 0 7 19169482 (3), 12153748 (3)

    Search CenterWatch for drugs/clinical trials and news about SHOX 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SHOX gene (2 alternative transcripts): 
    NM_000451.3  NM_006883.2  

    Unigene Cluster for SHOX:

    Short stature homeobox
    Hs.105932  [show with all ESTs]
    Unigene Representative Sequence: U89331
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559808 ENST00000554971 ENST00000560001 ENST00000558872 ENST00000381575
    ENST00000334060(uc004cpi.3) ENST00000381578(uc004cph.1)

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    hsa-miR-92a hsa-miR-137 hsa-miR-196a* hsa-miR-374b hsa-miR-25 hsa-miR-367 hsa-miR-16-1* hsa-miR-374a
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    Additional cDNA sequence: 

    U89331.1 Y11535.1 Y11536.1 

    4 DOTS entries:

    DT.120651921  DT.308671  DT.100648898  DT.121312346 

    8 AceView cDNA sequences:

    Y11536 Y11535 NM_000451 NM_006883 BV184529 AW291358 U89331 BF514224 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SHOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACCACTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SHOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SHOX

    SOURCE GeneReport for Unigene cluster: Hs.105932

    UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
    Tissue specificity: SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and
    SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in
    brain, kidney, liver and lung. Highly expressed in osteogenic cells

        SABiosciences Expression via Pathway-Focused PCR Array including SHOX: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SHOX gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SHOX1 short stature homeobox 84.99(n)
    93.47(a)
      418669  NM_001079724.1  NP_001073192.1 
    lizard
    (Anolis carolinensis)
    Reptilia SHOX26
    --
    72(a)
    1 → many
    3(14433463-14447877)
    zebrafish
    (Danio rerio)
    Actinopterygii shox1 short stature homeobox 75.85(n)
    87.28(a)
      664748  NM_001126411.1  NP_001119883.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343676
    --
    28(a)
    1 → many
    2L(10347822-10353905)


    ENSEMBL Gene Tree for SHOX (if available)
    TreeFam Gene Tree for SHOX (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SHOX gene
    UNCX2  ENSG000002585182  OTP2  SHOX22  
    6 SIMAP similar genes for SHOX using alignment to 4 protein entries:     SHOX_HUMAN (see all proteins):
    SHOX2    HOXB1    NKX2-5    RAX2    DUX2    PRRX1

    SHOX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SHOX
         3 CNVs: 33160 0821 33186
    Human Gene Mutation Database (HGMD): SHOX

    Locus Specific Mutation Databases (LSDB): SHOX
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SHOX for disorders           About GeneDecksing

    OMIM gene information: 312865   
    OMIM disorders: 300582  127300  249700  
    UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
  • Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD) [MIM:127300]. LWD is a dominantly
  • inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb
    segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal
    dislocation of the distal ulna
  • Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD) [MIM:249700]. LMD is an autosomal recessive
  • rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic
    and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all
    affected subjects reported to date
  • Defects in SHOX are a cause of idiopathic short stature (ISS) [MIM:300582]. Idiopathic short stature is
  • usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of
    national height standards in the absence of specific causative disorders

    20/30 diseases for SHOX (see all 30):    About MalaCards
    short stature    leri-weill dyschondrosteosis    rokitansky-kuster-hauser syndrome    shox-related haploinsufficiency disorders
    turner syndrome    langer mesomelic dysplasia    mesomelic dysplasia    mesomelic dysplasia kantaputra type
    langer mesomelic dwarfism    meier-gorlin syndrome    short stature, idiopathic familial    otitis media
    prader-willi syndrome    becker muscular dystrophy    peters anomaly    gonadal dysgenesis
    hypochondroplasia    triple x syndrome    dwarfism    premature ovarian failure

    2 diseases from the University of Copenhagen DISEASES database for SHOX:
    Turner syndrome     Hypochondroplasia

    10/19 Novoseek disease relationships for SHOX gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leri-weill dyschondrosteosis 99 63 10549307 (3), 10626546 (3), 11503314 (3), 15356038 (2) (see all 39)
    madelungs deformity 97.8 26 11874178 (3), 17028440 (2), 11408757 (1), 12362035 (1) (see all 17)
    langer mesomelic dysplasia 97.7 16 16807223 (1), 15173321 (1), 19724992 (1), 11186941 (1) (see all 13)
    short stature 93.2 199 17182655 (7), 11874178 (6), 10634394 (5), 11889216 (5) (see all 75)
    turners syndrome 91 52 11889216 (3), 19016538 (3), 10634394 (2), 9259282 (2) (see all 36)
    cubitus valgus 86.8 4 17182655 (1), 11889216 (1), 10599728 (1), 11889214 (1)
    skeletal dysplasia 77.8 6 18797583 (1), 11503314 (1), 18228171 (1), 17994562 (1)
    growth failure 71.8 12 10634394 (3), 15356038 (2), 17922307 (2), 19724992 (1) (see all 8)
    hypochondroplasia 71.8 3 12476453 (2), 11030412 (1)
    dwarfism 62.4 4 9590292 (1), 18228171 (1), 11260213 (1), 15214013 (1)

    GeneTests: SHOX
    SHOX-Related Haploinsufficiency Disorders

    Genetic Association Database (GAD): SHOX
    Human Genome Epidemiology (HuGE) Navigator: SHOX (3 documents)

    Export disorders for SHOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SHOX gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with SHOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHOG, a candidate gene for involvement in the short stature of Turner syndrome. (PubMed id 9259282)1, 2, 3, 9 Ellison J.W....Chiong W. (1997)
    2. Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. (PubMed id 9140395)1, 2, 3, 9 Rao E.... Rappold G.A. (1997)
    3. Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature. (PubMed id 11889216)1, 4, 9 Rappold G.A....Ogata T. (2002)
    4. SHOX nullizygosity and haploinsufficiency in a Japanese family: implication for the development of Turner skeletal features. (PubMed id 11889214)1, 2, 9 Ogata T.... Hattori T. (2002)
    5. Mutations in short stature homeobox containing gene (SHOX) in dyschondrosteosis but not in hypochondroplasia. (PubMed id 11030412)1, 2, 9 Grigelioniene G.... Hagenaes L. (2000)
    6. SHOX point mutations in dyschondrosteosis. (PubMed id 11403039)1, 2, 9 Huber C.... Cormier-Daire V. (2001)
    7. Allelic and nonallelic heterogeneity in dyschondrosteosis (Leri-Weill syndrome). (PubMed id 11891678)1, 2, 9 Cormier-Daire V.... Munnich A. (2001)
    8. SHOX intragenic microsatellite analysis in patients with short stature. (PubMed id 11874178)1, 9 Ezquieta B....Gracia R. (2002)
    9. PAR1 deletions downstream of SHOX are the most frequent defect in a Spanish cohort of Leri-Weill dyschondrosteosis (LWD) probands. (PubMed id 16941489)1, 9 Benito-Sanz S....Heath K.E. (2006)
    10. SHOX mutations in idiopathic short stature and Leri-Weill dyschondrosteosis: frequency and phenotypic variability. (PubMed id 17201812)1, 9 Jorge A.A....Mendonca B.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6473 HGNC: 10853 AceView: SHOX.1 Ensembl:ENSG00000185960 euGenes: HUgn6473
    ECgene: SHOX H-InvDB: SHOX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SHOX Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SHOX
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SHOXY

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SHOX gene:
    Search GeneIP for patents involving SHOX

    GeneCards and IP:
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