SHOX Gene
protein-coding GIFtS: 55
GCID: GC0XP000585
|
|
short stature homeobox
| |
Aliases
for SHOX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Short Stature Homeobox1 2 | | Pseudoautosomal Homeobox-Containing Osteogenic Protein2 3 | | PHOG1 2 3 5 | | Growth Control Factor, X-Linked2 | | GCFX1 2 5 | | Short Stature Homeobox Protein2 | | SS1 2 5 | | Short Stature Homeobox-Containing Protein3 | | SHOXY1 2 | | |
Export aliases for SHOX gene to outside databasesPrevious GC identifers: GC0XP000427 GC0YU900006 GC0XP000527 GC0YP000555 |
Summaries
for SHOX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SHOX:
This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotypeof Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternativelyspliced transcript variants encoding different isoforms have been noted for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266Function: Controls fundamental aspects of growth and development
Gene Wiki entry for SHOX (Short stature homeobox gene)
|
Genomic Views
for SHOX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_000024.9 NC_018934.1 NT_167193.1 NT_167201.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHOX gene promoter:
PPAR-alpha SRY
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHOX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.33;Yp11.3 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.33 and Yp11.32SHOX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP000585: view genomic region
(about GC identifiers)
Start:
|
585,079 bp from pter |
End:
|
620,146 bp from pter |
Size:
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35,068 bases |
Orientation:
|
plus strand |
1 alternative location:
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Proteins
for SHOX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266 (See
protein sequence)Recommended Name: Short stature homeobox protein Size: 292 amino acids; 32236 Da
Subcellular location: Nucleus (By similarity)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Ychromosomes
Secondary accessions: O00412 O00413 O15267Alternative splicing: 2 isoforms: O15266-1 O15266-2 Explore the universe of human proteins at neXtProt for SHOX: NX_O15266
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15266
SHOX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000442.1 NP_006874.1
ENSEMBL proteins: ENSP00000453617 ENSP00000452016 ENSP00000453707 ENSP00000453225 ENSP00000370987 ENSP00000335505 ENSP00000370990
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SHOX for ontologies About GeneDecksing
SHOX Antibody Products:
Assay Products for SHOX: |
Protein
Domains /
Families
for SHOX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHOX for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15266ProtoNet protein and cluster: O15266 2 Blocks protein families: IPB000047 Lambda and other repressor helix-turn-helix signature IPB003654 Paired-like homeodomain protein
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266Similarity: Belongs to the paired homeobox family. Bicoid subfamilySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for SHOX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266Function: Controls fundamental aspects of growth and developmentInduction: By retinoic acid and phorbol-12-myristate 13-acetate (PMA) Genatlas biochemistry entry for SHOX:short stature homeo box-containing gene,with two alternatively spliced forms SHOXa widely expressed,and SHOXbpredominantly found in bone marrow,fibroblast,homolog to murine OG-12a,OG-12b
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SHOX (NM_000451) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHOX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
SHOX for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SHOX:
|
Pathways & Interactions
for SHOX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHOX
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for SHOX (O152661, 3 ENSP000003709904) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SHOX for ontologies About GeneDecksing
|
Drugs & Compounds
for SHOX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SHOX for compounds About GeneDecksing
 Browse Tocris compounds for SHOX
2 Novoseek chemical compound relationships for SHOX gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| steroid |
0 |
2 |
12153748 (1), 11260213 (1) |
| estrogen |
0 |
7 |
19169482 (3), 12153748 (3) |
Search CenterWatch for drugs/clinical trials and news about SHOX
|
Transcripts
for SHOX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHOX gene (2 alternative transcripts): NM_000451.3 NM_006883.2 Unigene Cluster for SHOX: Short stature homeobox Hs.105932 [show with all ESTs]Unigene Representative Sequence: U893317 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559808 ENST00000554971 ENST00000560001 ENST00000558872 ENST00000381575
ENST00000334060(uc004cpi.3) ENST00000381578(uc004cph.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SHOX (NM_000451) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHOX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOX |
Additional cDNA sequence: U89331.1 Y11535.1 Y11536.1 4 DOTS entries: DT.120651921 DT.308671 DT.100648898 DT.121312346 8 AceView cDNA sequences: Y11536 Y11535 NM_000451 NM_006883 BV184529 AW291358 U89331 BF514224
GeneLoc Exon Structure
|
Expression
for SHOX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHOX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCACTGCC
About this image
See SHOX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHOX
SOURCE GeneReport for Unigene cluster: Hs.105932
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266Tissue specificity: SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast andSHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed inbrain, kidney, liver and lung. Highly expressed in osteogenic cells
SABiosciences Expression via Pathway-Focused PCR Array including SHOX: | Homeobox (HOX) Genes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHOX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SHOX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHOX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX |
Orthologs
for SHOX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SHOX gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for SHOX (if available)
TreeFam Gene Tree for SHOX (if available) |
Paralogs
for SHOX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHOX gene
- UNCX2 ENSG000002585182 OTP2 SHOX22
6 SIMAP similar genes for SHOX using alignment to 4 protein entries: SHOX_HUMAN (see all proteins):SHOX2 HOXB1 NKX2-5 RAX2 DUX2 PRRX1
SHOX for paralogs About GeneDecksing
|
Genomic Variants
for SHOX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SHOX
3 CNVs: 33160 0821 33186
Human Gene Mutation Database (HGMD): SHOX
Locus Specific Mutation Databases (LSDB): SHOX
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHOX |
|
Disorders
/ Diseases
for SHOX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHOX for disorders About GeneDecksing
OMIM gene information: 312865
OMIM disorders: 300582 127300 249700
UniProtKB/Swiss-Prot: SHOX_HUMAN, O15266
Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD) [MIM:127300]. LWD is a dominantlyinherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limbsegments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsaldislocation of the distal ulna Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD) [MIM:249700]. LMD is an autosomal recessiverare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelicand rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in allaffected subjects reported to date Defects in SHOX are a cause of idiopathic short stature (ISS) [MIM:300582]. Idiopathic short stature isusually defined as a height below the third percentile for chronological age or minus 2 standard deviations ofnational height standards in the absence of specific causative disorders
20/30  diseases for SHOX (see all 30): About MalaCardsshort stature leri-weill dyschondrosteosis rokitansky-kuster-hauser syndrome shox-related haploinsufficiency disorders
turner syndrome langer mesomelic dysplasia mesomelic dysplasia mesomelic dysplasia kantaputra type
langer mesomelic dwarfism meier-gorlin syndrome short stature, idiopathic familial otitis media
prader-willi syndrome becker muscular dystrophy peters anomaly gonadal dysgenesis
hypochondroplasia triple x syndrome dwarfism premature ovarian failure
2 diseases from the University of Copenhagen DISEASES database for SHOX:Turner syndrome Hypochondroplasia 10/19 Novoseek disease relationships for SHOX gene (see all 19) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leri-weill dyschondrosteosis |
99 |
63 |
10549307 (3), 10626546 (3), 11503314 (3), 15356038 (2), 18322641 (2), 17201812 (2), 17200153 (2), 15931687 (2), 15931595 (2), 16175500 (2), 10634394 (1), 16807223 (1), 15173321 (1), 9590292 (1), 11403039 (1), 15173249 (1), 16227037 (1), 12402330 (1), 11030412 (1), 17481601 (1), 16941489 (1), 14514349 (1), 11735031 (1), 11585080 (1), 19169498 (1), 15214013 (1), 11891678 (1), 10507731 (1), 17047016 (1), 14981722 (1), 18660847 (1), 16597678 (1), 10878753 (1), 18797583 (1), 17922307 (1), 19724992 (1), 11889216 (1), 10905666 (1), 16826534 (1) (see top 4) |
| madelungs deformity |
97.8 |
26 |
11874178 (3), 17028440 (2), 11408757 (1), 12362035 (1), 17182655 (1), 11889216 (1), 15356038 (1), 11260213 (1), 11134233 (1), 14513875 (1), 16175500 (1), 16597678 (1), 19724992 (1), 11523902 (1), 10878753 (1), 11735031 (1), 11739418 (1) (see top 4) |
| langer mesomelic dysplasia |
97.7 |
16 |
16807223 (1), 15173321 (1), 19724992 (1), 11186941 (1), 17922307 (1), 19850687 (1), 10878753 (1), 17481601 (1), 17935511 (1), 16175500 (1), 11889214 (1), 15214013 (1), 15931595 (1) (see top 4) |
| short stature |
93.2 |
199 |
17182655 (7), 11874178 (6), 10634394 (5), 11889216 (5), 17028440 (5), 10549307 (4), 18797583 (4), 11585080 (4), 16807223 (3), 19724992 (3), 17922307 (3), 10749976 (3), 15931595 (3), 16597678 (3), 12784295 (3), 16227037 (3), 14557470 (3), 14514349 (3), 19850687 (3), 19578035 (3), 11408757 (2), 15173321 (2), 19016538 (2), 17726696 (2), 17091221 (2), 15931687 (2), 20432819 (2), 17200153 (2), 12673642 (2), 9140395 (2), 17201812 (2), 11030412 (2), 11735031 (2), 11503314 (2), 16904661 (2), 17881654 (2), 9259282 (2), 11751690 (1), 12566529 (1), 16175500 (1), 14981722 (1), 11716161 (1), 11260213 (1), 18660847 (1), 15145945 (1), 12900572 (1), 12439897 (1), 12153748 (1), 14513875 (1), 11134233 (1), 9590293 (1), 17047016 (1), 11471178 (1), 10943824 (1), 10575123 (1), 20440962 (1), 11509862 (1), 16650979 (1), 12402330 (1), 11807867 (1), 10599728 (1), 17481601 (1), 11739418 (1), 10878753 (1), 9590292 (1), 10626546 (1), 19533800 (1), 17911654 (1), 15356038 (1), 11677662 (1), 11546827 (1), 16325853 (1), 12362035 (1), 10905666 (1), 15292358 (1) (see top 4) |
| turners syndrome |
91 |
52 |
11889216 (3), 19016538 (3), 10634394 (2), 9259282 (2), 10749976 (2), 11503314 (2), 11471178 (2), 10878753 (2), 11093045 (1), 11408757 (1), 11523902 (1), 17922307 (1), 11509862 (1), 16227037 (1), 12402330 (1), 11874178 (1), 10599728 (1), 17028440 (1), 11739418 (1), 11585080 (1), 19850687 (1), 15931595 (1), 11889214 (1), 11134233 (1), 17047016 (1), 9140395 (1), 18660847 (1), 10943824 (1), 20440962 (1), 17881654 (1), 10626546 (1), 19724992 (1), 15173321 (1), 16807223 (1), 17182655 (1), 11546827 (1) (see top 4) |
| cubitus valgus |
86.8 |
4 |
17182655 (1), 11889216 (1), 10599728 (1), 11889214 (1) |
| skeletal dysplasia |
77.8 |
6 |
18797583 (1), 11503314 (1), 18228171 (1), 17994562 (1) |
| growth failure |
71.8 |
12 |
10634394 (3), 15356038 (2), 17922307 (2), 19724992 (1), 17881654 (1), 19578035 (1), 17726696 (1), 10943824 (1) (see top 4) |
| hypochondroplasia |
71.8 |
3 |
12476453 (2), 11030412 (1) |
| dwarfism |
62.4 |
4 |
9590292 (1), 18228171 (1), 11260213 (1), 15214013 (1) |
GeneTests: SHOX
SHOX-Related Haploinsufficiency Disorders
Genetic Association Database (GAD): SHOX
Human Genome Epidemiology (HuGE) Navigator: SHOX (3 documents)
Export disorders for SHOX gene to outside databases
|
Publications
for SHOX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHOX gene, integrated from 9 sources (see all 150):
(articles sorted by number of sources associating them with SHOX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PHOG, a candidate gene for involvement in the short stature of Turner syndrome. (PubMed id 9259282)1, 2, 3, 9 Ellison J.W....Chiong W. (1997)
- Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. (PubMed id 9140395)1, 2, 3, 9 Rao E.... Rappold G.A. (1997)
- Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature. (PubMed id 11889216)1, 4, 9 Rappold G.A....Ogata T. (2002)
- SHOX nullizygosity and haploinsufficiency in a Japanese family: implication for the development of Turner skeletal features. (PubMed id 11889214)1, 2, 9 Ogata T.... Hattori T. (2002)
- Mutations in short stature homeobox containing gene (SHOX) in dyschondrosteosis but not in hypochondroplasia. (PubMed id 11030412)1, 2, 9 Grigelioniene G.... Hagenaes L. (2000)
- SHOX point mutations in dyschondrosteosis. (PubMed id 11403039)1, 2, 9 Huber C.... Cormier-Daire V. (2001)
- Allelic and nonallelic heterogeneity in dyschondrosteosis (Leri-Weill syndrome). (PubMed id 11891678)1, 2, 9 Cormier-Daire V.... Munnich A. (2001)
- SHOX intragenic microsatellite analysis in patients with short stature. (PubMed id 11874178)1, 9 Ezquieta B....Gracia R. (2002)
- PAR1 deletions downstream of SHOX are the most frequent defect in a Spanish cohort of Leri-Weill dyschondrosteosis (LWD) probands. (PubMed id 16941489)1, 9 Benito-Sanz S....Heath K.E. (2006)
- SHOX mutations in idiopathic short stature and Leri-Weill dyschondrosteosis: frequency and phenotypic variability. (PubMed id 17201812)1, 9 Jorge A.A....Mendonca B.B. (2007)
|
External Searches for SHOX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SHOX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SHOX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SHOX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SHOX | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SHOX | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SHOXY |
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About This Section
| Patent Information for SHOX gene:
Search GeneIP for patents involving SHOX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SHOX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SHOX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHOX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHOX | | | OriGene Protein Over-expression Lysate for SHOX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SHOX | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SHOX | | OriGene Custom Protein Services for SHOX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHOX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHOX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHOX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHOX |
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| | | | Search Tocris compounds for SHOX |
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 | | | SHOX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOX |
|  |  |  | | | | Search ThermoFisher Antibodies for SHOX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOX |
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