SHOC2 Gene
protein-coding GIFtS: 56
GCID: GC10P112679
|
|
soc-2 suppressor of clear homolog (C. elegans)(Previous names: soc-2 (suppressor of clear, C.elegans) homolog )
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Aliases
for SHOC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Soc-2 Suppressor Of Clear Homolog (C. Elegans)1 2 | | SUR-81 | | SOC21 2 5 | | Soc-2 (Suppressor Of Clear, C.Elegans) Homolog1 | | SUR81 2 5 | | Leucine-Rich Repeat Protein SHOC-22 | | KIAA08621 3 | | Protein Soc-2 Homolog3 | | SIAA08622 5 | | Protein Sur-8 Homolog3 | | SOC-21 | | |
Export aliases for SHOC2 gene to outside databasesPrevious GC identifers: GC10P111572 GC10P111912 GC10P112810 GC10P112343 GC10P112389 GC10P112669 GC10P106308 |
Summaries
for SHOC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SHOC2:
This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated inprotein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers inthe RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome withloose anagen hair. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: SHOC2_HUMAN, Q9UQ13Function: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates inMAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259'inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes
Gene Wiki entry for SHOC2
|
Genomic Views
for SHOC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHOC2 gene promoter:
AhR Elk-1 AML1a FOXD1 XBP-1 Arnt AREB6 POU2F1 NRF-2 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHOC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25SHOC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P112679: view genomic region
(about GC identifiers)
Start:
|
112,679,301 bp from pter |
End:
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112,773,425 bp from pter |
Size:
|
94,125 bases |
Orientation:
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plus strand |
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Proteins
for SHOC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHOC2_HUMAN, Q9UQ13 (See
protein sequence)Recommended Name: Leucine-rich repeat protein SHOC-2 Size: 582 amino acids; 64888 Da
Subunit: Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) andprotein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBB2IP; disrupts the interaction with RAF1 and Ras,leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRASbut not H-Ras/HRAS
Subcellular location: Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation
Sequence caution: Sequence=BAA74885.2; Type=Erroneous initiation; Sequence=BAG52235.1; Type=Erroneous initiation;Sequence=CAH72813.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K9W8 B3KR23 O76063 Q5VZS8 Q5VZS9Alternative splicing: 2 isoforms: Q9UQ13-1 Q9UQ13-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SHOC2: NX_Q9UQ13
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UQ13
SHOC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001255968.1 NP_031399.2
ENSEMBL proteins: ENSP00000358464 ENSP00000408275 ENSP00000265277
Human Recombinant Protein Products for SHOC2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SHOC2 for ontologies About GeneDecksing
SHOC2 Antibody Products:
Assay Products for SHOC2: |
Protein
Domains /
Families
for SHOC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHOC2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UQ13ProtoNet protein and cluster: Q9UQ13 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: SHOC2_HUMAN, Q9UQ13Similarity: Belongs to the SHOC2 familySimilarity: Contains 20 LRR (leucine-rich) repeats |
Function
for SHOC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SHOC2_HUMAN, Q9UQ13Function: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates inMAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259'inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes Genatlas biochemistry entry for SHOC2:leucine-rich protein,cytoplasmic,ubiquitously expressed,homolog to C elegans soc2,suppressor of clear(clr-1),implicated in fibroblast growth receptor signaling
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SHOC2 for ontologies About GeneDecksing
Phenotypes:
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Shoc2):
SHOC2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Shoc2tm1.2Mhan for SHOC2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SHOC2 (NM_007373) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHOC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOC2 |
|
Pathways & Interactions
for SHOC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | EGFR1 Signaling Pathway | |
1  BioSystems Pathway for SHOC2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SHOC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/608 Interacting proteins for SHOC2 (Q9UQ132, 3 ENSP000003584644) via UniProtKB, MINT, STRING, and/or I2D (see all 608)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SHOC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SHOC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SHOC2
Search CenterWatch for drugs/clinical trials and news about SHOC2
|
Transcripts
for SHOC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHOC2 gene (2 alternative transcripts): NM_001269039.1 NM_007373.3 Unigene Cluster for SHOC2: Soc-2 suppressor of clear homolog (C. elegans) Hs.104315 [show with all ESTs]Unigene Representative Sequence: NM_0073737 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369452(uc001kzl.4 uc009xxx.3 uc010qrg.2 uc001kzn.3)
ENST00000480155 ENST00000489390 ENST00000489783 ENST00000451838 ENST00000497305
ENST00000265277
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SHOC2 (NM_007373) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHOC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOC2 |
Additional cDNA sequence: AB020669.1 AF054828.1 AF068920.1 AK090820.1 AK292833.1 AK293271.1 BC044752.1 BC050445.1 BX649055.1 7 DOTS entries: DT.99953490 DT.315292 DT.121276785 DT.97845369 DT.100795857 DT.121276662 DT.121276759 24/217 AceView cDNA sequences (see all 217): AA243821 BM720220 BC050445 H03424 AA804470 CR592821 BU624956 F09053 AI828246 BM671977 BU430201 AA463466 AA765486 AB020669 AI921303 AF054828 BX474627 BX951340 NM_007373 AA334388 BG697930 BU431583 BI855816 AI206628
GeneLoc Exon Structure
|
Expression
for SHOC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHOC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTAGTTTTG
About this image
See SHOC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHOC2
SOURCE GeneReport for Unigene cluster: Hs.104315
SABiosciences Custom PCR Arrays for SHOC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHOC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHOC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHOC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOC2 |
Orthologs
for SHOC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SHOC2 gene from 8/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SHOC21 |
soc-2 suppressor of clear homolog (C. elegans) |
84.5(n)
94.57(a) |
|
423894 NM_001031236.1 NP_001026407.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SHOC26 |
-- |
91(a) |
1 ↔ 1 |
3(45794332-45821837) |
African clawed frog
(Xenopus laevis) |
Amphibia |
shoc2-prov2 |
soc-2 suppressor of clear homolog (C. elegans) |
78.76(n) |
|
BC042263.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
shoc21 |
soc-2 suppressor of clear homolog (C. elegans) |
75.88(n)
91.62(a) |
|
555476 NM_001044786.1 NP_001038251.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sur-81 , 3 |
RAS interactor3
CG5407-PA1 |
62(a)3
57.14(n)1
62.62(a)1 |
|
90A53
420931 NM_142363.61 NP_650620.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
soc-21 , 3 |
Protein SOC-21 |
58(a)3
56.6(n)1
58(a)1 |
|
IV(5127596-5133964)3
1772861 NM_171332.21 NP_741391.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
GSO11 |
LRR receptor-like serine/threonine-protein kinase GSO1 |
43.29(n)
33.63(a) |
|
827760 NM_118133.2 NP_193747.2 |
rice
(Oryza sativa) |
Liliopsida |
Os07g04984001 |
hypothetical protein |
39.9(n)
34.45(a) |
|
4343304 NM_001066245.2 NP_001059710.2 |
ENSEMBL Gene Tree for SHOC2 (if available)
TreeFam Gene Tree for SHOC2 (if available) |
Paralogs
for SHOC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHOC2 gene
- LRRC72 LRRC22 ERBB2IP2 MFHAS12 LRRC182 LRRC302 LRRC12 PIDD2
- LRRIQ42 SCRIB2 LRRD12 LRRC10B2 LRRC392 LRRC402 LRRC102
SHOC2 for paralogs About GeneDecksing
|
Genomic Variants
for SHOC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SHOC2 (112679301 - 112773425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SHOC2: --
Human Gene Mutation Database (HGMD): SHOC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHOC2 |
|
Disorders
/ Diseases
for SHOC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHOC2 for disorders About GeneDecksing
OMIM gene information: 602775
OMIM disorders: 607721
UniProtKB/Swiss-Prot: SHOC2_HUMAN, Q9UQ13
Defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) [MIM:607721]. Asyndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebralptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable,sparse, thin and slow-growing hair
8  diseases for SHOC2: About MalaCardsnoonan-like syndrome with loose anagen hair noonan syndrome-like disorder lymphangiectasis noonan syndrome
costello syndrome leopard syndrome cryptorchidism ptosis
4 diseases from the University of Copenhagen DISEASES database for SHOC2:Noonan syndrome Costello syndrome LEOPARD syndrome Cryptorchidism Export disorders for SHOC2 gene to outside databases
|
Publications
for SHOC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHOC2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SHOC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (PubMed id 9674433)1, 2, 3, 9 Sieburth D.S.... Han M. (1998)
- Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. (PubMed id 9618511)1, 2, 3, 9 Selfors L.M.... Stern M.J. (1998)
- The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PubMed id 10783161)1, 2, 3 Li W.... Guan K.-L. (2000)
- Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. (PubMed id 16301319)1, 2, 9 Dai P.... Mei L. (2006)
- A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PubMed id 16630891)1, 2, 9 Rodriguez-Viciana P....McCormick F. (2006)
- Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. (PubMed id 19684605)1, 2 Cordeddu V.... Tartaglia M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
- Shoc2 is targeted to late endosomes and required for E rk1/2 activation in EGF-stimulated cells. (PubMed id 22606262)1 Galperin E....Sorkin A. (2012)
|
External Searches for SHOC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SHOC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SHOC2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SHOC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SHOC2 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt121.shtml |
|
| | |
About This Section
| Patent Information for SHOC2 gene:
Search GeneIP for patents involving SHOC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SHOC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SHOC2 | | OriGene shRNA RFP for SHOC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SHOC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHOC2 | | | OriGene Protein Over-expression Lysate for SHOC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SHOC2 | | OriGene 3'-UTR Clone for SHOC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHOC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SHOC2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SHOC2 | | OriGene Custom Protein Services for SHOC2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHOC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHOC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHOC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHOC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHOC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHOC2 |
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| | | | Search Tocris compounds for SHOC2 |
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 | | | SHOC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHOC2 |
|  |  |  |  | | | | ThermoFisher Antibodies for SHOC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHOC2 |
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