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Aliases for SHOC2 Gene

Aliases for SHOC2 Gene

  • Soc-2 Suppressor Of Clear Homolog (C. Elegans) 2 3
  • SIAA0862 3 6
  • SOC2 3 6
  • SUR8 3 6
  • Soc-2 (Suppressor Of Clear, C.Elegans) Homolog 2
  • Leucine-Rich Repeat Protein SHOC-2 3
  • Protein Soc-2 Homolog 4
  • Protein Sur-8 Homolog 4
  • KIAA0862 4

External Ids for SHOC2 Gene

Previous GeneCards Identifiers for SHOC2 Gene

  • GC10P111572
  • GC10P111912
  • GC10P112810
  • GC10P112343
  • GC10P112389
  • GC10P112669
  • GC10P106308
  • GC10P112679

Summaries for SHOC2 Gene

Entrez Gene Summary for SHOC2 Gene

  • This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

GeneCards Summary for SHOC2 Gene

SHOC2 (Soc-2 Suppressor Of Clear Homolog (C. Elegans)) is a Protein Coding gene. Diseases associated with SHOC2 include noonan-like syndrome with loose anagen hair and noonan syndrome 6. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for SHOC2 Gene

  • Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the Ser-259 inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Gene Wiki entry for SHOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHOC2 Gene

Genomics for SHOC2 Gene

Regulatory Elements for SHOC2 Gene

Genomic Location for SHOC2 Gene

110,919,543 bp from pter
111,013,667 bp from pter
94,125 bases
Plus strand

Genomic View for SHOC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHOC2 Gene

Proteins for SHOC2 Gene

  • Protein details for SHOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat protein SHOC-2
    Protein Accession:
    Secondary Accessions:
    • A8K9W8
    • B3KR23
    • O76063
    • Q5VZS8
    • Q5VZS9

    Protein attributes for SHOC2 Gene

    582 amino acids
    Molecular mass:
    64888 Da
    Quaternary structure:
    • Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBB2IP; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS.
    • Sequence=BAA74885.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG52235.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH72813.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SHOC2 Gene


neXtProt entry for SHOC2 Gene

Proteomics data for SHOC2 Gene at MOPED

Post-translational modifications for SHOC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SHOC2 Gene

No data available for DME Specific Peptides for SHOC2 Gene

Domains for SHOC2 Gene

Protein Domains for SHOC2 Gene

Suggested Antigen Peptide Sequences for SHOC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UQ13
  • Belongs to the SHOC2 family.
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SHOC2: view

No data available for Gene Families for SHOC2 Gene

Function for SHOC2 Gene

Molecular function for SHOC2 Gene

GENATLAS Biochemistry: leucine-rich protein,cytoplasmic,ubiquitously expressed,homolog to C elegans soc2,suppressor of clear (clr-1),implicated in fibroblast growth receptor signaling
UniProtKB/Swiss-Prot Function: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the Ser-259 inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Gene Ontology (GO) - Molecular Function for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019888 protein phosphatase regulator activity TAS 16630891
GO:0019903 protein phosphatase binding IDA 16630891
genes like me logo Genes that share ontologies with SHOC2: view
genes like me logo Genes that share phenotypes with SHOC2: view

Animal Models for SHOC2 Gene

MGI Knock Outs for SHOC2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SHOC2 Gene

Localization for SHOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHOC2 Gene

Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.

Subcellular locations from

Jensen Localization Image for SHOC2 Gene COMPARTMENTS Subcellular localization image for SHOC2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IDA 16630891
GO:0005634 nucleus IDA 19684605
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 9618511
genes like me logo Genes that share ontologies with SHOC2: view

Pathways for SHOC2 Gene

SuperPathways for SHOC2 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with SHOC2: view

Pathways by source for SHOC2 Gene

1 BioSystems pathway for SHOC2 Gene

Gene Ontology (GO) - Biological Process for SHOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction NAS 9674433
GO:0008543 fibroblast growth factor receptor signaling pathway NAS 9618511
GO:0046579 positive regulation of Ras protein signal transduction IMP 16630891
GO:0050790 regulation of catalytic activity TAS 16630891
genes like me logo Genes that share ontologies with SHOC2: view

Transcripts for SHOC2 Gene

Unigene Clusters for SHOC2 Gene

Soc-2 suppressor of clear homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SHOC2 Gene

No ASD Table

Relevant External Links for SHOC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SHOC2 Gene

mRNA expression in normal human tissues for SHOC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SHOC2 Gene

SOURCE GeneReport for Unigene cluster for SHOC2 Gene Hs.104315

genes like me logo Genes that share expressions with SHOC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SHOC2 Gene

Orthologs for SHOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SHOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SHOC2 35
  • 99.83 (n)
  • 100 (a)
SHOC2 36
  • 100 (a)
(Bos Taurus)
Mammalia SHOC2 35
  • 96.05 (n)
  • 99.83 (a)
SHOC2 36
  • 100 (a)
(Canis familiaris)
Mammalia SHOC2 35
  • 95.93 (n)
  • 99.66 (a)
SHOC2 36
  • 100 (a)
(Mus musculus)
Mammalia Shoc2 35
  • 91.92 (n)
  • 98.45 (a)
Shoc2 16
Shoc2 36
  • 98 (a)
(Monodelphis domestica)
Mammalia SHOC2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia SHOC2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Shoc2 35
  • 90.55 (n)
  • 97.94 (a)
(Gallus gallus)
Aves SHOC2 35
  • 84.5 (n)
  • 94.57 (a)
SHOC2 36
  • 96 (a)
(Anolis carolinensis)
Reptilia SHOC2 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia shoc2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia shoc2 35
  • 77.4 (n)
  • 91.39 (a)
(Danio rerio)
Actinopterygii shoc2 35
  • 74.93 (n)
  • 90.02 (a)
shoc2 36
  • 92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004485 35
  • 59.03 (n)
  • 64.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sur-8 35
  • 57.21 (n)
  • 62.62 (a)
Sur-8 36
  • 52 (a)
Sur-8 37
  • 62 (a)
(Caenorhabditis elegans)
Secernentea soc-2 35
  • 56.6 (n)
  • 58 (a)
soc-2 36
  • 55 (a)
soc-2 37
  • 58 (a)
(Oryza sativa)
Liliopsida Os10g0119200 35
  • 44.32 (n)
  • 35.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for SHOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SHOC2 Gene

Gene Tree for SHOC2 (if available)
Gene Tree for SHOC2 (if available)

Paralogs for SHOC2 Gene

genes like me logo Genes that share paralogs with SHOC2: view

Variants for SHOC2 Gene

Sequence variations from dbSNP and Humsavar for SHOC2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1114802 -- 110,949,788(+) CAAGA(A/C)CCAAT intron-variant
rs1327551 -- 111,008,438(+) TGTAA(A/T)TATCT intron-variant
rs1327552 -- 111,013,321(+) TTTCC(A/G)TTTAG utr-variant-3-prime
rs1327556 -- 110,961,650(+) GTTTG(G/T)GGGTC intron-variant
rs1359849 -- 110,944,622(+) actta(C/T)aataa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHOC2 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831985 CNV Gain+Loss 17160897
nsv7548 CNV Insertion 18451855
nsv518667 CNV Loss 19592680
esv2674974 CNV Deletion 23128226

Relevant External Links for SHOC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHOC2 Gene

Disorders for SHOC2 Gene

(1) OMIM Diseases for SHOC2 Gene (602775)


  • Noonan syndrome-like disorder with loose anagen hair (NSLH) [MIM:607721]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269 PubMed:19684605}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for SHOC2 Gene

genes like me logo Genes that share disorders with SHOC2: view

Publications for SHOC2 Gene

  1. Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. (PMID: 9618511) Selfors L.M. … Stern M.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (PMID: 9674433) Sieburth D.S. … Han M. (Cell 1998) 2 3 4 23
  3. Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. (PMID: 16301319) Dai P. … Mei L. (J. Biol. Chem. 2006) 3 4 23
  4. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. (PMID: 16630891) Rodriguez-Viciana P. … McCormick F. (Mol. Cell 2006) 3 4 23
  5. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PMID: 10783161) Li W. … Guan K.-L. (Genes Dev. 2000) 2 3 4

Products for SHOC2 Gene

Sources for SHOC2 Gene

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