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SHKBP1 Gene

protein-coding   GIFtS: 52
GCID: GC19P041082

SH3KBP1 Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3KBP1 Binding Protein 11 2
Sb12
SH3KBP1-Binding Protein 12

External Ids:    HGNC: 192141   Entrez Gene: 927992   Ensembl: ENSG000001604107   UniProtKB: Q8TBC33   

Export aliases for SHKBP1 gene to outside databases

Previous GC identifers: GC19P045777 GC19P037517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SHKBP1 Gene:
SHKBP1 (SH3KBP1 binding protein 1) is a protein-coding gene. Diseases associated with SHKBP1 include korean hemorrhagic fever, and yellow fever. An important paralog of this gene is KCTD3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SHKBP1 gene promoter:
         HSF1 (long)   XBP-1   Egr-4   Roaz   GATA-1   GATA-2   Egr-2   Pax-3   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSHKBP1 promoter sequence
   Search Chromatin IP Primers for SHKBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SHKBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

SHKBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHKBP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041082:  view genomic region     (about GC identifiers)

Start:
41,082,757 bp from pter      End:
41,097,305 bp from pter
Size:
14,549 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SHKB1_HUMAN, Q8TBC3 (See protein sequence)
Recommended Name: SH3KBP1-binding protein 1  
Size: 707 amino acids; 76344 Da
Subunit: Interacts with SH3KBP1 (By similarity)
Secondary accessions: Q8N2I6 Q8WY93 Q96IB8
Alternative splicing: 2 isoforms:  Q8TBC3-1   Q8TBC3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHKBP1: NX_Q8TBC3

Explore proteomics data for SHKBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys28, Lys181, Lys359, Lys435, Lys512
  • Modification sites at PhosphoSitePlus

  • See SHKBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612401.2  
    ENSEMBL proteins: 
     ENSP00000291842   ENSP00000470514   ENSP00000472711   ENSP00000469878   ENSP00000472813  
     ENSP00000471406   ENSP00000469014   ENSP00000468885   ENSP00000470517   ENSP00000471173  
     ENSP00000469713   ENSP00000471296   ENSP00000472222   ENSP00000471408   ENSP00000470505  
     ENSP00000471845  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold
     IPR001680 WD40_repeat
     IPR003131 T1-type_BTB
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TBC3

    ProtoNet protein and cluster: Q8TBC3

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: SHKB1_HUMAN, Q8TBC3
    Similarity: Belongs to the KCTD3 family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 WD repeats


    SHKBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SHKBP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SHKBP1:
     Decreased viability with pacli  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SHKBP1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SHKBP1

    miRNA
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    miRTarBase miRNAs that target SHKBP1:
    hsa-mir-615-3p (MIRT040411)

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    7 qRT-PCR Assays for microRNAs that regulate SHKBP1:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-328 hsa-miR-449b hsa-miR-802 hsa-miR-449a hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSHKBP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SHKBP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHKBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    chloroplast1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SHKBP1
    Interactions:

        Search GeneGlobe Interaction Network for SHKBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SHKBP1 (Q8TBC32, 3 ENSP000002918424) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL7A1Q023882, 3, ENSP000003323714MINT-64034 I2D: score=4 STRING: ENSP00000332371
    SH3KBP1Q96B973, ENSP000003809214I2D: score=2 STRING: ENSP00000380921
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    GRB2P629933, ENSP000003390074I2D: score=4 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    SHKBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SHKBP1 (SHKB1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SHKBP1 gene: 
    NM_138392.3  

    Unigene Cluster for SHKBP1:

    SH3KBP1 binding protein 1
    Hs.26506  [show with all ESTs]
    Unigene Representative Sequence: AF258553
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000291842(uc002oob.3 uc002ooc.3 uc010xvl.1 uc002ooe.3 uc010xvm.2 uc010xvn.2)
    ENST00000595803 ENST00000600733 ENST00000595945 ENST00000599575 ENST00000599716
    ENST00000600718 ENST00000600552 ENST00000598558 ENST00000595631 ENST00000595523
    ENST00000597325 ENST00000594973 ENST00000598907 ENST00000598201 ENST00000595874
    ENST00000600791 ENST00000602011
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SHKBP1:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-328 hsa-miR-449b hsa-miR-802 hsa-miR-449a hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSHKBP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SHKBP1
    Predesigned siRNA for gene silencing in human, mouse, rat SHKBP1
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    GenScript: all cDNA clones in your preferred vector: SHKBP1 (NM_138392)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SHKBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHKBP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SHKBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SHKBP1
      QuantiTect SYBR Green Assays in human, mouse, rat SHKBP1
      QuantiFast Probe-based Assays in human, mouse, rat SHKBP1

    Additional mRNA sequence: 

    AF258553.1 AK075057.1 AK123695.1 AK297006.1 AK300808.1 AK300819.1 AK312748.1 AY007117.1 
    BC007653.1 BC022855.1 

    17 DOTS entries:

    DT.444049  DT.100804541  DT.100828101  DT.97850065  DT.100828102  DT.121501884  DT.121501908  DT.95347839 
    DT.100649702  DT.95141582  DT.100834578  DT.101984412  DT.102832206  DT.121501911  DT.95141586  DT.95141625 
    DT.95141627 

    Selected AceView cDNA sequences (see all 324):

    BG686698 BX382191 BQ057892 BQ227488 CB120743 BM673871 CR590661 BE378181 
    CK823869 BQ278787 AI818013 CR618516 AY007117 BE336792 BX424207 CR598538 
    BX372492 BX642140 BI870259 BU176363 BQ877669 BM789794 BM709110 CB150332 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SHKBP1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^
    SP1:                                -                             -     -           -           -                                                               
    SP2:                                -                             -     -           -           -                                         -     -               
    SP3:                                                              -     -           -           -                                                               
    SP4:                                -                             -                 -           -                                                               
    SP5:                                -                             -     -                       -                                                               

    ExUns: 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c
    SP1:        -     -                                                                           
    SP2:        -     -                                                                           
    SP3:        -     -                                                                           
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for SHKBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SHKBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTTGGG
    SHKBP1 Expression
    About this image


    SHKBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Spleen (Hematopoietic System)
    SHKBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SHKBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26506
        Custom PCR Arrays for SHKBP1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SHKBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHKBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SHKBP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Shkbp11 , 5 Sh3kbp1 binding protein 11, 5 85.8(n)1
    93.18(a)1
      7 (15.88 cM)5
    1921921  NM_138676.21  NP_619617.21 
     273421335 
    chicken
    (Gallus gallus)
    Aves SHKBP16
    SH3KBP1 binding protein 1
    68(a)
    1 ↔ 1
    AADN03013343.1(21-2019)
    lizard
    (Anolis carolinensis)
    Reptilia SHKBP16
    SH3KBP1 binding protein 1
    65(a)
    1 ↔ 1
    LGf(1988532-1999118)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004865871 SH3KBP1-binding protein 1-like 68.6(n)
    75.27(a)
      100486587  XM_002938802.2  XP_002938848.1 
    zebrafish
    (Danio rerio)
    Actinopterygii shkbp11 SH3KBP1 binding protein 1 69.43(n)
    74.85(a)
      562395  XM_001920900.4  XP_001920935.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG94676
    --
    46(a)
    1 → many
    3R(5623491-5626773)
    worm
    (Caenorhabditis elegans)
    Secernentea T23B12.66
    Protein T23B12.6 (T23B12.6) mRNA, complete cds
    44(a)
    1 → many
    V(8457613-8460419) WBGene00020721


    ENSEMBL Gene Tree for SHKBP1 (if available)
    TreeFam Gene Tree for SHKBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SHKBP1 gene
    KCTD32  
    11 SIMAP similar genes for SHKBP1 using alignment to 17 protein entries:     SHKB1_HUMAN (see all proteins):
    KCTD3    KCTD17    KCTD21    KCTD6    KCTD19    KCTD5
    TNFAIP1    KCTD13    KCTD10    KCTD15    KCTD1

    SHKBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SHKBP1 (see all 440)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs169743651,2
    C,F,H--41082868(+) GTCATT/CCATCT 2 /I syn118Minor allele frequency- C:0.16MN EA NS NA 2352
    rs1870758401,2
    C--41082932(+) GGGCGA/GGAAGC 1 -- int10--------
    rs1909385251,2
    --41082966(+) TGGGGA/GAATCC 1 -- int10--------
    rs356847861,2
    C--41082994(+) CTCCG-/CCCCCC 1 -- int10--------
    rs1132964941,2
    C--41082997(+) CGCCCG/CCCCCC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs2012432511,2
    --41083093(+) CTCACA/CCGCTC 1 -- int10--------
    rs2008132671,2
    --41083134(+) CCGCCC/TAGATT 1 -- int10--------
    rs1124983241,2
    C,F--41083251(+) GACCTC/AATATC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1166722081,2
    C,F--41083306(+) GTCTTC/TTGAGC 2 L syn11Minor allele frequency- T:0.02WA 118
    rs22906821,2
    C,F,H--41083444(+) ATCCTC/TTGCCC 1 -- int122Minor allele frequency- T:0.26NS EA NA CSA WA EU 3701

    HapMap Linkage Disequilibrium report for SHKBP1 (41082757 - 41097305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SHKBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718566CNV Deletion23290073
    dgv3871n71CNV Loss21882294
    nsv911718CNV Loss21882294
    nsv911725CNV Loss21882294
    nsv911726CNV Loss21882294
    nsv911724CNV Loss21882294
    dgv3870n71CNV Loss21882294
    dgv3869n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for SHKBP1:    
    About MalaCards
    korean hemorrhagic fever    yellow fever    histoplasmosis    hemorrhagic fever
    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for SHKBP1:
    Korean hemorrhagic fever

    SHKBP1 for disorders           About GeneDecksing


    Export disorders for SHKBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SHKBP1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SHKBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. (PubMed id 11152963)1, 3 Borinstein S.C....Bogler O. (Cell. Signal. 2000)
    2. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    3. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. (PubMed id 21830225)1 Feng L....Geng J.G. (Cell Biochem. Funct. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92799 HGNC: 19214 AceView: LOC92799 Ensembl:ENSG00000160410 euGenes: HUgn92799
    ECgene: SHKBP1 H-InvDB: SHKBP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SHKBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SHKBP1 gene:
    Search GeneIP for patents involving SHKBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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