SHKBP1 Gene
protein-coding GIFtS: 49
GCID: GC19P041082
|
|
SH3KBP1 binding protein 1
| |
Aliases
for SHKBP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3KBP1 Binding Protein 11 2 | | Sb11 2 | | PP2031 | | SH3KBP1-Binding Protein 12 |
Export aliases for SHKBP1 gene to outside databasesPrevious GC identifers: GC19P045777 GC19P037517 |
Summaries
for SHKBP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SHKBP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SHKBP1 gene promoter:
HSF1 (long) XBP-1 Egr-4 Roaz GATA-1 GATA-2 Egr-2 Pax-3 HSF1short aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SHKBP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHKBP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2SHKBP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P041082: view genomic region
(about GC identifiers)
Start:
|
41,082,757 bp from pter |
End:
|
41,097,305 bp from pter |
Size:
|
14,549 bases |
Orientation:
|
plus strand |
|
Proteins
for SHKBP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SHKB1_HUMAN, Q8TBC3 (See
protein sequence)Recommended Name: SH3KBP1-binding protein 1 Size: 707 amino acids; 76344 Da
Subunit: Interacts with SH3KBP1 (By similarity)
Secondary accessions: Q8N2I6 Q8WY93 Q96IB8Alternative splicing: 2 isoforms: Q8TBC3-1 Q8TBC3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SHKBP1: NX_Q8TBC3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TBC3
SHKBP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612401.2
ENSEMBL proteins: ENSP00000291842
Human Recombinant Protein Products for SHKBP1:
SHKBP1 Antibody Products:
Assay Products for SHKBP1: |
Protein
Domains /
Families
for SHKBP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SHKBP1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8TBC3ProtoNet protein and cluster: Q8TBC3 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: SHKB1_HUMAN, Q8TBC3Similarity: Belongs to the KCTD3 familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 WD repeats |
Function
for SHKBP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
SHKBP1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SHKBP1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHKBP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHKBP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SHKBP1 (NM_138392) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHKBP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHKBP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHKBP1 |
|
Pathways & Interactions
for SHKBP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SHKBP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/15 Interacting proteins for SHKBP1 (Q8TBC32, 3 ENSP000002918424) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
SHKBP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SHKBP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SHKBP1
Search CenterWatch for drugs/clinical trials and news about SHKBP1 / SHKB1
|
Transcripts
for SHKBP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SHKBP1 gene: NM_138392.3 Unigene Cluster for SHKBP1: SH3KBP1 binding protein 1 Hs.26506 [show with all ESTs]Unigene Representative Sequence: AF2585531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000291842(uc002oob.3 uc002ooc.3 uc010xvl.1 uc002ooe.3 uc010xvm.2 uc010xvn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SHKBP1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SHKBP1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SHKBP1 (NM_138392) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SHKBP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHKBP1 |
Additional cDNA sequence: AF258553.1 AK075057.1 AK123695.1 AK297006.1 AK300808.1 AK300819.1 AK312748.1 AY007117.1 BC007653.1 BC022855.1 17 DOTS entries: DT.444049 DT.100804541 DT.100828101 DT.97850065 DT.100828102 DT.121501884 DT.121501908 DT.95347839 DT.100649702 DT.95141582 DT.100834578 DT.101984412 DT.102832206 DT.121501911 DT.95141586 DT.95141625 DT.95141627 24/324 AceView cDNA sequences (see all 324): BU163512 BF770014 BU145282 BC007653 BQ691211 BF980715 BQ278787 CR598538 BQ227488 AA928027 CB120743 BX401550 BX372492 AF258553 CB152174 BF769692 BQ070173 AL523486 CK823869 BX642140 BI524030 T27113 BQ072852 BM673871
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SHKBP1 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SHKBP1
|
Expression
for SHKBP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SHKBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCTTGGG
About this image
See SHKBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SHKBP1
SOURCE GeneReport for Unigene cluster: Hs.26506
SABiosciences Custom PCR Arrays for SHKBP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SHKBP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SHKBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHKBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHKBP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHKBP1 |
Orthologs
for SHKBP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SHKBP1 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for SHKBP1 (if available)
TreeFam Gene Tree for SHKBP1 (if available) |
Paralogs
for SHKBP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SHKBP1 gene
- KCTD32
1 SIMAP similar gene for SHKBP1 using alignment to 17 protein entries: SHKB1_HUMAN (see all proteins):KCTD3
SHKBP1 for paralogs About GeneDecksing
|
Genomic Variants
for SHKBP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SHKBP1 (41082757 - 41097305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SHKBP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHKBP1 |
|
Disorders
/ Diseases
for SHKBP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SHKBP1 for disorders About GeneDecksing
4  diseases for SHKBP1: About MalaCardskorean hemorrhagic fever yellow fever histoplasmosis ovarian cancer
1 disease from the University of Copenhagen DISEASES database for SHKBP1:Korean hemorrhagic fever Export disorders for SHKBP1 gene to outside databases
|
Publications
for SHKBP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SHKBP1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with SHKBP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. (PubMed id 11152963)1, 3 Borinstein S.C....Bogler O. (2000)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- SH3KBP1-binding protein 1 prevents epidermal growth f actor receptor degradation by the interruption of c-Cbl-CIN85 complex. (PubMed id 21830225)1 Feng L....Geng J.G. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PubMed id 19531213)1 Havrylov S....Redowicz M.J. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for SHKBP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SHKBP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SHKBP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SHKBP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SHKBP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SHKBP1 gene:
Search GeneIP for patents involving SHKBP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SHKBP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SHKBP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SHKBP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHKBP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SHKBP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SHKBP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SHKBP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SHKBP1 |
| |  |  |  |  | | | | |
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 | | | SHKBP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SHKBP1 |
|  |  |  |  | | | | ThermoFisher Antibody for SHKBP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SHKBP1 |
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