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Aliases for SHISAL2B Gene

Aliases for SHISAL2B Gene

  • Shisa Like 2B 2 3
  • Family With Sequence Similarity 159 Member B 2 3 5
  • FAM159B 3 4 5
  • Family With Sequence Similarity 159, Member B 2
  • Membrane Protein FAM159B 3

External Ids for SHISAL2B Gene

Previous HGNC Symbols for SHISAL2B Gene

  • FAM159B

Summaries for SHISAL2B Gene

GeneCards Summary for SHISAL2B Gene

SHISAL2B (Shisa Like 2B) is a Protein Coding gene. An important paralog of this gene is SHISAL2A.

Additional gene information for SHISAL2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISAL2B Gene

Genomics for SHISAL2B Gene

GeneHancer (GH) Regulatory Elements for SHISAL2B Gene

Promoters and enhancers for SHISAL2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I064690 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.5 474 1.6 ZSCAN4 KLF17 ZNF76 ZNF2 ZNF335 GLIS2 ZNF366 SCRT2 KLF7 EGR2 SHISAL2B SREK1IP1
GH05I065072 Enhancer 0.6 FANTOM5 dbSUPER 37.2 +382.8 382777 0.4 POLR2A REST RUNX3 SHISAL2B GC05M065036 GC05P065124
GH05I065125 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +437.2 437152 4 PKNOX1 ZNF10 ZFP37 FEZF1 ZNF501 ZNF843 ATF2 FOSL1 ZNF335 JUND ADAMTS6 SHISAL2B ENSG00000207439 LOC100419140
GH05I064665 Enhancer 0.5 ENCODE 12 -24.2 -24226 0.7 MITF FOSL1 RAD51 USF1 NFYB USF2 FOS SHISAL2B RGS7BP MRPL49P1 GC05P064585
GH05I065075 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4 +386.2 386198 1.8 HDAC1 PKNOX1 ARNT RAD21 CHAMP1 ZNF766 ATF7 BCLAF1 RUNX3 NCOA1 SHISAL2B GC05M065036 GC05P065124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHISAL2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for SHISAL2B Gene

Genomic Locations for SHISAL2B Gene
chr5:64,690,308-64,718,190
(GRCh38/hg38)
Size:
27,883 bases
Orientation:
Plus strand
chr5:63,986,135-64,014,017
(GRCh37/hg19)

Genomic View for SHISAL2B Gene

Genes around SHISAL2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISAL2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISAL2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISAL2B Gene

Proteins for SHISAL2B Gene

  • Protein details for SHISAL2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKW6-F159B_HUMAN
    Recommended name:
    Membrane protein FAM159B
    Protein Accession:
    A6NKW6

    Protein attributes for SHISAL2B Gene

    Size:
    160 amino acids
    Molecular mass:
    17663 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SHISAL2B Gene

Post-translational modifications for SHISAL2B Gene

No Post-translational modifications

Other Protein References for SHISAL2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISAL2B Gene

Domains & Families for SHISAL2B Gene

Gene Families for SHISAL2B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISAL2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISAL2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKW6

UniProtKB/Swiss-Prot:

F159B_HUMAN :
  • Belongs to the FAM159 family.
Family:
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with SHISAL2B: view

Function for SHISAL2B Gene

Phenotypes From GWAS Catalog for SHISAL2B Gene

Phenotypes for SHISAL2B Gene

GenomeRNAi human phenotypes for SHISAL2B:
genes like me logo Genes that share phenotypes with SHISAL2B: view

miRNA for SHISAL2B Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SHISAL2B Gene

Localization for SHISAL2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISAL2B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SHISAL2B gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for SHISAL2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISAL2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SHISAL2B Gene

Pathways & Interactions for SHISAL2B Gene

SuperPathways for SHISAL2B Gene

No Data Available

Interacting Proteins for SHISAL2B Gene

Gene Ontology (GO) - Biological Process for SHISAL2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISAL2B Gene

Drugs & Compounds for SHISAL2B Gene

No Compound Related Data Available

Transcripts for SHISAL2B Gene

mRNA/cDNA for SHISAL2B Gene

(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISAL2B Gene

No ASD Table

Relevant External Links for SHISAL2B Gene

GeneLoc Exon Structure for
SHISAL2B
ECgene alternative splicing isoforms for
SHISAL2B

Expression for SHISAL2B Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISAL2B Gene:

SHISAL2B

Evidence on tissue expression from TISSUES for SHISAL2B Gene

  • Pancreas(2.9)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISAL2B Gene

Orthologs for SHISAL2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISAL2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM159B 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia FAM159B 33 34
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Fam159b 33
  • 88.61 (n)
mouse
(Mus musculus)
Mammalia Fam159b 33 16 34
  • 87.05 (n)
dog
(Canis familiaris)
Mammalia FAM159B 33 34
  • 85.83 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM159B 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM159B 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159b 33
  • 63.49 (n)
Species where no ortholog for SHISAL2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SHISAL2B Gene

ENSEMBL:
Gene Tree for SHISAL2B (if available)
TreeFam:
Gene Tree for SHISAL2B (if available)

Paralogs for SHISAL2B Gene

Paralogs for SHISAL2B Gene

genes like me logo Genes that share paralogs with SHISAL2B: view

Variants for SHISAL2B Gene

Sequence variations from dbSNP and Humsavar for SHISAL2B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000170529 -- 64,688,467(+) T/C upstream_transcript_variant
rs1000289536 -- 64,695,850(+) G/A intron_variant
rs1000620794 -- 64,694,383(+) T/C intron_variant
rs1000728644 -- 64,715,588(+) A/G intron_variant
rs1000739943 -- 64,715,436(+) AGGAG/AG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SHISAL2B Gene

Variant ID Type Subtype PubMed ID
dgv5692n100 CNV gain 25217958
esv2752074 CNV gain 17911159
nsv1124912 CNV duplication 24896259
nsv598390 CNV gain 21841781

Variation tolerance for SHISAL2B Gene

Gene Damage Index Score: 6.26; 76.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISAL2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISAL2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISAL2B Gene

Disorders for SHISAL2B Gene

Additional Disease Information for SHISAL2B

No disorders were found for SHISAL2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISAL2B Gene

Publications for SHISAL2B Gene

  1. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for SHISAL2B Gene

Sources for SHISAL2B Gene

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