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Aliases for SHISAL2A Gene

Aliases for SHISAL2A Gene

  • Shisa Like 2A 2 3
  • Family With Sequence Similarity 159 Member A 2 3 5
  • FAM159A 3 4 5
  • Family With Sequence Similarity 159, Member A 2
  • Membrane Protein FAM159A 3
  • WWLS2783 3
  • PRO7171 3

External Ids for SHISAL2A Gene

Previous HGNC Symbols for SHISAL2A Gene

  • FAM159A

Summaries for SHISAL2A Gene

GeneCards Summary for SHISAL2A Gene

SHISAL2A (Shisa Like 2A) is a Protein Coding gene. An important paralog of this gene is SHISAL2B.

Additional gene information for SHISAL2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISAL2A Gene

Genomics for SHISAL2A Gene

GeneHancer (GH) Regulatory Elements for SHISAL2A Gene

Promoters and enhancers for SHISAL2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I052631 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.2 +3.9 3913 8.1 HDGF PKNOX1 YBX1 IRF4 ZNF766 ZNF207 ATF7 RUNX3 RXRA CAVIN1 SHISAL2A ZCCHC11 GPX7 MAGOH PRPF38A ENSG00000230953 ENSG00000272100 CC2D1B ENSG00000266993 ORC1
GH01I052601 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 12.4 -28.1 -28139 4.3 SOX13 PKNOX1 BACH1 ZNF644 ZNF316 POLR2A SCRT2 ATF7 PRDM10 NR2F6 GPX7 CC2D1B SHISAL2A ZCCHC11 GC01P052619
GH01I052550 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 2.5 -78.5 -78540 5.6 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 ZNF207 ZCCHC11 ENSG00000272371 MAGOH ENSG00000266993 CC2D1B RPS13P2 ENSG00000230953 GPX7 C1orf123 PRPF38A
GH01I052674 Enhancer 0.9 ENCODE 5.3 +45.7 45729 5.7 HDGF FOXA2 PKNOX1 ATF1 YY1 TCF12 FOS ATF7 RXRA NCOA1 GPX7 ZCCHC11 ZYG11B COA7 SCP2 SHISAL2A PIR34624 GC01P052685
GH01I052640 Enhancer 1 FANTOM5 ENCODE dbSUPER 4 +9.7 9718 1.2 HDGF PKNOX1 RFX1 RELA IKZF1 NBN ATF7 IKZF2 GPX7 SHISAL2A ZCCHC11 PRPF38A CC2D1B GC01P052637 PIR34624
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SHISAL2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for SHISAL2A Gene

Genomic Locations for SHISAL2A Gene
chr1:52,631,439-52,669,683
(GRCh38/hg38)
Size:
38,245 bases
Orientation:
Plus strand
chr1:53,099,016-53,135,355
(GRCh37/hg19)

Genomic View for SHISAL2A Gene

Genes around SHISAL2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SHISAL2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SHISAL2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISAL2A Gene

Proteins for SHISAL2A Gene

  • Protein details for SHISAL2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWV7-F159A_HUMAN
    Recommended name:
    Membrane protein FAM159A
    Protein Accession:
    Q6UWV7
    Secondary Accessions:
    • Q6ZRG4

    Protein attributes for SHISAL2A Gene

    Size:
    190 amino acids
    Molecular mass:
    20306 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ88984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SHISAL2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHISAL2A Gene

Post-translational modifications for SHISAL2A Gene

No Post-translational modifications

Other Protein References for SHISAL2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISAL2A Gene

Domains & Families for SHISAL2A Gene

Gene Families for SHISAL2A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SHISAL2A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SHISAL2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWV7

UniProtKB/Swiss-Prot:

F159A_HUMAN :
  • Belongs to the FAM159 family.
Family:
  • Belongs to the FAM159 family.
genes like me logo Genes that share domains with SHISAL2A: view

Function for SHISAL2A Gene

genes like me logo Genes that share phenotypes with SHISAL2A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SHISAL2A Gene

Localization for SHISAL2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISAL2A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SHISAL2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SHISAL2A: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SHISAL2A Gene

Pathways & Interactions for SHISAL2A Gene

SuperPathways for SHISAL2A Gene

No Data Available

Interacting Proteins for SHISAL2A Gene

Gene Ontology (GO) - Biological Process for SHISAL2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SHISAL2A Gene

Drugs & Compounds for SHISAL2A Gene

No Compound Related Data Available

Transcripts for SHISAL2A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISAL2A Gene

No ASD Table

Relevant External Links for SHISAL2A Gene

GeneLoc Exon Structure for
SHISAL2A
ECgene alternative splicing isoforms for
SHISAL2A

Expression for SHISAL2A Gene

NURSA nuclear receptor signaling pathways regulating expression of SHISAL2A Gene:

SHISAL2A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SHISAL2A Gene

Orthologs for SHISAL2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISAL2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM159A 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia FAM159A 33 34
  • 84.39 (n)
cow
(Bos Taurus)
Mammalia FAM159A 33 34
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Fam159a 33
  • 82.19 (n)
mouse
(Mus musculus)
Mammalia Fam159a 33 16 34
  • 81.83 (n)
chicken
(Gallus gallus)
Aves FAM159A 33 34
  • 71.2 (n)
lizard
(Anolis carolinensis)
Reptilia FAM159A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam159a 33
  • 60.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536524 33
  • 59.8 (n)
Species where no ortholog for SHISAL2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISAL2A Gene

ENSEMBL:
Gene Tree for SHISAL2A (if available)
TreeFam:
Gene Tree for SHISAL2A (if available)

Paralogs for SHISAL2A Gene

Paralogs for SHISAL2A Gene

genes like me logo Genes that share paralogs with SHISAL2A: view

Variants for SHISAL2A Gene

Sequence variations from dbSNP and Humsavar for SHISAL2A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000069463 -- 52,643,831(+) C/T intron_variant
rs1000082835 -- 52,642,199(+) A/T intron_variant
rs1000085896 -- 52,650,226(+) G/C intron_variant
rs1000283563 -- 52,631,461(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000311991 -- 52,667,521(+) T/C genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SHISAL2A Gene

Variant ID Type Subtype PubMed ID
esv1918082 CNV deletion 18987734
esv2672204 CNV deletion 23128226
esv2748129 CNV deletion 23290073
esv2748141 CNV deletion 23290073
esv3586053 CNV loss 21293372
nsv1001535 CNV gain 25217958

Variation tolerance for SHISAL2A Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SHISAL2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SHISAL2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISAL2A Gene

Disorders for SHISAL2A Gene

Additional Disease Information for SHISAL2A

No disorders were found for SHISAL2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SHISAL2A Gene

Publications for SHISAL2A Gene

  1. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SHISAL2A Gene

Sources for SHISAL2A Gene

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