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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SHISA9 Gene

protein-coding GIFtS: 40
GCID: GC16P012995

shisa homolog 9 (Xenopus laevis)

Explore 2 diseases affiliated with
SHISA9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Shisa Homolog 9 (Xenopus Laevis)¹ ²
CKAMP44² ⁵
Cystine-Knot AMPAR Modulating Protein²
Protein Shisa-9²

External Ids:	HGNC: 37231¹	Entrez Gene: 729993²	Ensembl: ENSG00000237515⁷	OMIM: 613346⁵	UniProtKB: B4DS77³

Export aliases for SHISA9 gene to outside databases

Previous GC identifer: GC16P012912

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SHSA9_HUMAN, B4DS77

Function: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors

(ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SHISA9
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SHISA9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.12 Ensembl cytogenetic band: 16p13.12 HGNC cytogenetic band: 16p13.12

SHISA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SHISA9 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P012995: view genomic region (about GC identifiers)

Start:	12,995,477 bp from pter	End:	13,334,273 bp from pter
Size:	338,797 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: SHSA9_HUMAN, B4DS77 (See protein sequence)

Recommended Name: Protein shisa-9 precursor

Size: 424 amino acids; 46925 Da

Subunit: Component of some AMPA receptors (ionotropic glutamate receptors) complex, at least composed of some AMPA

receptor (GRIA1, GRIA2 and/or GRIA3), CACNG2 and SHISA9, as well as low level of DLG4 (By similarity)

Subcellular location: Cell projection, dendritic spine membrane; Single-pass type I membrane protein (By similarity).

Cell junction, synapse (By similarity)

Secondary accessions: C9J314 C9JCE9

Alternative splicing: 3 isoforms: B4DS77-1 B4DS77-2 B4DS77-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SHISA9: NX_B4DS77

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_B4DS77

SHISA9 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (2 alternative transcripts):

NP_001138676.2 NP_001138677.2

ENSEMBL proteins:

ENSP00000407958 ENSP00000395245 ENSP00000454014 ENSP00000453410

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008328	ionotropic glutamate receptor complex	ISS	--
GO:0030054	cell junction	IEA	--
GO:0032591	dendritic spine membrane	ISS	--
GO:0045202	synapse	ISS	--

SHISA9 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SHISA9 for domains About GeneDecksing

1 InterPro domain/family:

IPR026910 Shisa

Graphical View of Domain Structure for InterPro Entry B4DS77

ProtoNet protein and cluster: B4DS77

UniProtKB/Swiss-Prot: SHSA9_HUMAN, B4DS77

Similarity: Belongs to the shisa family. SHISA9 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SHSA9_HUMAN, B4DS77

Function: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors

(ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses

(By similarity)

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SHISA9

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0048172	regulation of short-term neuronal synaptic plasticity	ISS	--

SHISA9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for SHISA9 gene (2 alternative transcripts):

NM_001145204.2 NM_001145205.1

Unigene Cluster for SHISA9:

Shisa homolog 9 (Xenopus laevis)

Hs.130661 [show with all ESTs]

Unigene Representative Sequence: NM_001145204

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000424107 ENST00000423335 ENST00000482916 ENST00000566106 ENST00000558583(uc010uyy.2)

ENST00000558318(uc002dcd.2)

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Additional cDNA sequence:

AJ002784.1 AK000877.1 AK026131.1 AK094972.1 AK299610.1 AK309038.1 AK309193.1 CR627300.1

CR749545.1

6 DOTS entries:

DT.75170453 DT.407673 DT.427514 DT.92032947 DT.95247377 DT.120680728

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SHISA9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGACATC

About this image

SHISA9 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for SHISA9

SOURCE GeneReport for Unigene cluster: Hs.130661

SABiosciences Custom PCR Arrays for SHISA9

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SHISA9 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SHISA9¹	shisa homolog 9 (Xenopus laevis)	72.48(n) 76.17(a)		416419 XM_414733.3 XP_414733.3
lizard (Anolis carolinensis)	Reptilia	--	--	59(a)	1 ↔ 1	GL343841.1(151308-158169)
zebrafish (Danio rerio)	Actinopterygii	shisa9¹	shisa homolog 9 (Xenopus laevis)	62.02(n) 58.47(a)		541382 NM_001013509.1 NP_001013527.1

ENSEMBL Gene Tree for SHISA9 (if available)
TreeFam Gene Tree for SHISA9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SHISA9 gene

SHISA6² SHISA8² SHISA7²

2 SIMAP similar genes for SHISA9 using alignment to 3 protein entries: SHSA9_HUMAN (see all proteins):

SHISA8 SHISA6

SHISA9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138958006^1,2		--	12993891(+)	`CTATTA/GTAATG`	2	--	us2k¹		0	--	--	--	--
rs117253254^1,2		--	12993981(+)	`CAATGT/CCTTGC`	2	--	us2k¹		1		NA	120
rs115872248^1,2	F	--	12994050(+)	`GGGGCG/AATTAG`	2	--	us2k¹		1		WA	118
rs11644362^1,2	C,F,A,H	--	12994097(+)	`CCCAAT/CAAATC`	2	--	us2k¹		27		NS EA NA WA CSA	2770
rs67025692^1,2	C	--	12994441(+)	`GCTAG-/GAGA GAGAG`	2	--	us2k¹		1		NA	2
rs60344370^1,2	C	--	12994442(+)	`GAGAG-/AGAG GGCAG`	2	--	us2k¹		1		NA	2
rs74650991^1,2	C	--	12994444(+)	`GCTAG-/GAGA GAGAG`	2	--	us2k¹		0	--	--	--	--
rs185594822^1,2		--	12994465(+)	`GAAACA/TCAGAG`	2	--	us2k¹		0	--	--	--	--
rs190124784^1,2		--	12994596(+)	`GGTCCC/GGGAGG`	2	--	us2k¹		0	--	--	--	--
rs36056252^1,2	C,F	--	12994672(+)	`GGTGTG/TCCCTC`	2	--	us2k¹		9		NA WA CSA EA	369

HapMap Linkage Disequilibrium report for SHISA9 (12995477 - 13245477 bp, first 250kb of SHISA9)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for SHISA9
13 CNVs: 87970 58748 61494 77187 87968 66940 77186 77189 43920 77188 87969 77190 102215
2 Indels: 77191 77192

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SHISA9 for disorders           About GeneDecksing

OMIM gene information: 613346    OMIM disorders: --

2 diseases for SHISA9:    About MalaCards

schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: SHISA9 (1 document)

Export disorders for SHISA9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SHISA9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SHISA9)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
CKAMP44: a brain-specific protein attenuating short-t erm synaptic plasticity in the dentate gyrus. (PubMed id 20185686)¹ von Engelhardt J....Monyer H. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)¹ Adkins D.E....van den Oord E.J. (2010)
Identification of loci associated with schizophrenia by genome-wide association and follow-up. (PubMed id 18677311)¹ O'Donovan M.C....Owen M.J. (2008)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 729993	HGNC: 37231	Ensembl:ENSG00000237515	euGenes: HUgn729993	ECgene: SHISA9
H-InvDB: SHISA9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SHISA9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SHISA9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SHISA9 gene:
Search GeneIP for patents involving SHISA9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene Custom Antibody Services for SHISA9		OriGene Custom Protein Services for SHISA9
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	GenScript Custom Purified and Recombinant Proteins Services for SHISA9		GenScript cDNA clones with any tag delivered in your preferred vector for SHISA9
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ThermoFisher Antibodies for SHISA9

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SHISA9

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SHISA9

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SHISA9 gene at Home site.

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SHISA9 Gene

shisa homolog 9 (Xenopus laevis)

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SHISA9 Gene

shisa homolog 9 (Xenopus laevis)

Aliasesfor SHISA9 gene

Summariesfor SHISA9 gene

Genomic Viewsfor SHISA9 gene

Proteinsfor SHISA9 gene

Protein Domains /Familiesfor SHISA9 gene

Functionfor SHISA9 gene

Pathways & Interactionsfor SHISA9 gene

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Genome Databases showing SHISA9 gene

Other Databases showing SHISA9 gene

Specialized Databases showing SHISA9 gene

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for SHISA9 gene

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for SHISA9 gene

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for SHISA9 gene

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for SHISA9 gene

Protein Domains /
Families
for SHISA9 gene

Function
for SHISA9 gene

Pathways & Interactions
for SHISA9 gene

Drugs & Compounds
for SHISA9 gene

Transcripts
for SHISA9 gene

Expression
for SHISA9 gene

Orthologs
for SHISA9 gene

Paralogs
for SHISA9 gene

Genomic Variants
for SHISA9 gene

Disorders / Diseases
for SHISA9 gene

Publications
for SHISA9 gene

Intellectual Property
for SHISA9 gene

Products
for SHISA9 gene