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Aliases for SHISA9 Gene

Aliases for SHISA9 Gene

  • Shisa Family Member 9 2 3
  • CKAMP44 3 6
  • Cystine-Knot AMPAR Modulating Protein 3
  • Shisa Homolog 9 (Xenopus Laevis) 2
  • Protein Shisa-9 3
  • Shisa Homolog 9 3

External Ids for SHISA9 Gene

Previous GeneCards Identifiers for SHISA9 Gene

  • GC16P012995
  • GC16P012912

Summaries for SHISA9 Gene

GeneCards Summary for SHISA9 Gene

SHISA9 (Shisa Family Member 9) is a Protein Coding gene. An important paralog of this gene is SHISA8.

UniProtKB/Swiss-Prot for SHISA9 Gene

  • Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SHISA9 Gene

Genomics for SHISA9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SHISA9 Gene

Start:
12,901,620 bp from pter
End:
13,240,416 bp from pter
Size:
338,797 bases
Orientation:
Plus strand

Genomic View for SHISA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SHISA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SHISA9 Gene

No data available for Regulatory Elements for SHISA9 Gene

Proteins for SHISA9 Gene

  • Protein details for SHISA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B4DS77-SHSA9_HUMAN
    Recommended name:
    Protein shisa-9
    Protein Accession:
    B4DS77
    Secondary Accessions:
    • C9J314
    • C9JCE9

    Protein attributes for SHISA9 Gene

    Size:
    424 amino acids
    Molecular mass:
    46925 Da
    Quaternary structure:
    • Component of some AMPA receptors (ionotropic glutamate receptors) complex, at least composed of some AMPA receptor (GRIA1, GRIA2 and/or GRIA3), CACNG2 and SHISA9, as well as low level of DLG4.

    Alternative splice isoforms for SHISA9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SHISA9 Gene

Proteomics data for SHISA9 Gene at MOPED

Post-translational modifications for SHISA9 Gene

  • Glycosylation at Asn45, Asn89, and Asn116
  • Modification sites at PhosphoSitePlus

Other Protein References for SHISA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SHISA9 Gene

Domains for SHISA9 Gene

Gene Families for SHISA9 Gene

HGNC:

Protein Domains for SHISA9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SHISA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B4DS77

UniProtKB/Swiss-Prot:

SHSA9_HUMAN :
  • B4DS77
Family:
  • Belongs to the shisa family. SHISA9 subfamily.
genes like me logo Genes that share domains with SHISA9: view

Function for SHISA9 Gene

Molecular function for SHISA9 Gene

UniProtKB/Swiss-Prot Function: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SHISA9 Gene

Localization for SHISA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SHISA9 Gene

Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SHISA9 Gene COMPARTMENTS Subcellular localization image for SHISA9 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SHISA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008328 ionotropic glutamate receptor complex ISS --
GO:0030054 cell junction IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex IEA --
GO:0032591 dendritic spine membrane ISS --
GO:0045202 synapse ISS --
genes like me logo Genes that share ontologies with SHISA9: view

Pathways for SHISA9 Gene

SuperPathways for SHISA9 Gene

No Data Available

Interacting Proteins for SHISA9 Gene

Gene Ontology (GO) - Biological Process for SHISA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity ISS --
genes like me logo Genes that share ontologies with SHISA9: view

No data available for Pathways by source for SHISA9 Gene

Transcripts for SHISA9 Gene

mRNA/cDNA for SHISA9 Gene

(9) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SHISA9 Gene

Shisa homolog 9 (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SHISA9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SHISA9
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SHISA9 Gene

No ASD Table

Relevant External Links for SHISA9 Gene

GeneLoc Exon Structure for
SHISA9
ECgene alternative splicing isoforms for
SHISA9

Expression for SHISA9 Gene

mRNA expression in normal human tissues for SHISA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SHISA9 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.2), Brain - Anterior cingulate cortex (BA24) (5.7), Brain - Frontal Cortex (BA9) (5.4), Brain - Caudate (basal ganglia) (4.7), Brain - Hypothalamus (4.6), and Brain - Putamen (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SHISA9 Gene

SOURCE GeneReport for Unigene cluster for SHISA9 Gene Hs.130661

genes like me logo Genes that share expressions with SHISA9: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SHISA9 Gene

Orthologs for SHISA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SHISA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SHISA9 35
  • 99.44 (n)
  • 100 (a)
SHISA9 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SHISA9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SHISA9 35
  • 93.63 (n)
  • 95.75 (a)
SHISA9 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Shisa9 35
  • 90.88 (n)
  • 93.63 (a)
Shisa9 16
Shisa9 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SHISA9 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Shisa9 35
  • 89.47 (n)
  • 92.64 (a)
chicken
(Gallus gallus)
Aves SHISA9 35
  • 71.25 (n)
  • 74.45 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia shisa9 35
  • 68 (n)
  • 71.69 (a)
zebrafish
(Danio rerio)
Actinopterygii shisa9a 35
  • 63.43 (n)
  • 61.52 (a)
shisa9a 36
  • 46 (a)
OneToMany
shisa9b 36
  • 42 (a)
OneToMany
Species with no ortholog for SHISA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SHISA9 Gene

ENSEMBL:
Gene Tree for SHISA9 (if available)
TreeFam:
Gene Tree for SHISA9 (if available)

Paralogs for SHISA9 Gene

Paralogs for SHISA9 Gene

Selected SIMAP similar genes for SHISA9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SHISA9: view

Variants for SHISA9 Gene

Sequence variations from dbSNP and Humsavar for SHISA9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs20501 -- 13,102,356(+) CTATT(C/G)TGGTA intron-variant
rs129123 -- 13,169,309(+) ATTTG(C/T)GGTGG intron-variant
rs149227 -- 13,207,125(-) CACCA(G/T)GCCCA intron-variant
rs149228 -- 13,210,617(-) CCTCA(G/T)GTATG intron-variant
rs149916 -- 13,144,626(-) AATGA(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SHISA9 Gene

Variant ID Type Subtype PubMed ID
nsv833142 CNV Loss 17160897
nsv827557 CNV Gain 20364138
nsv1737 CNV Loss 18451855
esv2713990 CNV Deletion 23290073
esv2713991 CNV Deletion 23290073
esv275394 CNV Loss 21479260
esv2713992 CNV Deletion 23290073
nsv511565 CNV Loss 21212237
esv2713993 CNV Deletion 23290073
esv2713994 CNV Deletion 23290073
esv1009468 CNV Deletion 20482838
esv1257667 CNV Deletion 17803354
esv2453404 CNV Deletion 19546169
esv1005806 CNV Deletion 20482838
esv2365778 CNV Deletion 18987734
esv22866 CNV Gain+Loss 19812545
nsv827558 CNV Loss 20364138
nsv820320 CNV Deletion 20802225
nsv512425 CNV Loss 21212237
nsv819710 CNV Gain 19587683
esv2713995 CNV Deletion 23290073
dgv461n67 CNV Gain 20364138
esv9240 CNV Loss 19470904
esv2665133 CNV Deletion 23128226
nsv1738 CNV Insertion 18451855

Relevant External Links for SHISA9 Gene

HapMap Linkage Disequilibrium report
SHISA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SHISA9 Gene

Disorders for SHISA9 Gene

Relevant External Links for SHISA9

Genetic Association Database (GAD)
SHISA9
Human Genome Epidemiology (HuGE) Navigator
SHISA9
genes like me logo Genes that share disorders with SHISA9: view

No data available for UniProtKB/Swiss-Prot for SHISA9 Gene

Publications for SHISA9 Gene

  1. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins D.E. … van den Oord E.J. (Mol. Psychiatry 2011) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of loci associated with schizophrenia by genome-wide association and follow-up. (PMID: 18677311) O'Donovan M.C. … Cloninger C.R. (Nat. Genet. 2008) 3 48
  5. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. (PMID: 20185686) von Engelhardt J. … Monyer H. (Science 2010) 3

Products for SHISA9 Gene

Sources for SHISA9 Gene

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